CN109276701A - 一种治疗痛经的药物组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗痛经的药物组合物及其制备方法,按照重量份,包括如下原料:元胡120‑170重量份、当归80‑120重量份、桃仁80‑120重量份、红花80‑120重量份、川芎80‑120重量份、丹参120‑180重量份、香附120‑180重量份、附子80‑120重量份、干姜80‑120重量份、乌药80‑120重量份、紫石英80‑120重量份、巴戟天80‑120重量份和冰片6‑12重量份。本发明的治疗痛经的药组合物以香附、附子、干姜温经;以元胡、乌药行气;以当归、川芎、红花活血;以丹参、冰片化瘀;再以巴戟天、紫石英作用于肾脏,填充经期耗伤的精血,通过温经行气,活血化瘀,便可药到病除。
Description
技术领域
本发明属于医药技术领域,具体涉及一种治疗痛经的药物组合物及其制备方法。
背景技术
痛经是妇科常见病和多发病,病因多,病机复杂,反复性大,治疗棘手,尤其是未婚女青年及月经初期少女更为普遍,表现为妇女经期或行经前后,周期性发生下腹部胀痛、冷痛、灼痛、刺痛、隐痛、坠痛、绞痛、痉挛性疼痛、撕裂性疼痛,疼痛延至骶腰背部,甚至涉及大腿及足部,常伴有全身症状:乳房胀痛、肛门坠胀、腰闷烦躁、悲伤易怒、心惊失眠、头痛头晕、恶心呕吐、胃痛腹泻、倦怠乏力、面色苍白、四肢冰凉、冷汗淋漓、虚脱昏厥等症状。其发病之高、范围之广、周期之近、痛苦之大,严重影响了广大妇女的工作和学习,降低了生活的质量。
痛经之痛,不通则痛;经者,月经之经,就是子宫胞脉之经。不通则凝,而血热者行,血寒则凝。由此可知,月经不通而痛是宫寒宫冷所致。治疗的关键就是温经行气,活血化瘀,便可药到病除。
目前通常口服西药治疗,西药主要采用甾体激素类药物抑制排卵,及前列腺素拮抗物,解痉镇痛类药物,但是只能暂时缓解疼痛,容易复发,达不到根治的目的。
鉴于以上原因,特提出本发明。
发明内容
为了解决现有技术存在的以上问题,本发明提供了一种治疗痛经的药物组合物及其制备方法,本发明的中药组合物可以通过口服或者外敷,被人体快速吸收,在服用30-40分钟即可以止痛。
为实现上述目的,本发明采用如下技术方案:
一种治疗痛经的药物组合物,按照重量份,包括如下原料:元胡120-170重量份、当归80-120重量份、桃仁80-120重量份、红花80-120重量份、川芎80-120重量份、丹参120-180重量份、香附120-180重量份、附子80-120重量份、干姜80-120重量份、乌药80-120重量份、紫石英80-120重量份、巴戟天80-120重量份和冰片6-12重量份。
元胡又名延胡索、玄胡,为罂粟科紫堇属多年生草本植物,性温,味辛苦,入心、脾、肝、肺,是活血化瘀、行气止痛之妙品,尤以止痛之功效而著称于世。
当归甘补辛散,苦泄温通,既能补血,又可活血,且兼行气止痛,能主治一切血症,为血病之要品,尤为妇科良药。
桃仁性甘平、味苦,入肺、肝、大肠经;有破血行瘀,润燥滑肠的功效;治经闭、痛经、瘕瘕痞块,跌打损伤、肠燥便秘。
红花活血通经,散瘀止痛,有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。有活血化瘀,散湿去肿的功效。
川芎常用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症。
丹参具有活血祛瘀,通经止痛,清心除烦,凉血消痈之功效。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
香附用于肝郁气滞,胸胁胀痛,疝气疼痛,乳房胀痛,脾胃气滞,脘腹痞闷,胀满疼痛,月经不调,经闭痛经。
附子用于亡阳虚脱,肢冷脉微,心阳不足,胸痹心痛,虚寒吐泻,脘腹冷痛,肾阳虚衰,阳痿宫冷,阴寒水肿,阳虚外感,寒湿痹痛。
干姜用于脘腹冷痛,呕吐泄泻,肢冷脉微,寒饮喘咳。
乌药用于寒凝气滞,胸腹胀痛,气逆喘急,膀胱虚冷,遗尿尿频,疝气疼痛,经寒腹痛。
紫石英镇心,安神,降逆气,暖子宫。治虚劳惊悸,咳逆上气,妇女血海虚寒不孕。
巴戟天常用于用于阳痿遗精,宫冷不孕,月经不调,小腹冷痛,风湿痹痛,筋骨痿软。
冰片味辛、苦,微寒;归心、肝、肺经;清香宣散,具有开窍醒神,清热散毒,明目退翳的功效,主治热病高热神昏,中风痰厥惊痫,暑湿蒙蔽清窍,喉痹耳聋,口疮齿肿,疮痈疳痔,目赤肿痛,翳膜遮睛。
本发明的治疗痛经的药物组合物,以香附、附子、干姜温经;以元胡、乌药行气;以当归、川芎、红花活血;以丹参、冰片化瘀;再以巴戟天、紫石英作用于肾脏,填充经期耗伤的精血。诸药合用,标本兼治,快速高效,一般服药后30-40分钟,即可止痛。
进一步的,按照重量份,包括如下原料:元胡145-155重量份、当归95-105重量份、桃仁95-105重量份、红花95-105重量份、川芎95-105重量份、丹参145-155重量份、香附145-155重量份、附子95-105重量份、干姜95-105重量份、乌药95-105重量份、紫石英95-105重量份、巴戟天95-105重量份和冰片8-10重量份。
进一步的,按照重量份,包括如下原料:元胡150重量份、当归100重量份、桃仁100重量份、红花100重量份、川芎100重量份、丹参150重量份、香附150重量份、附子100重量份、干姜100重量份、乌药100重量份、紫石英100重量份、巴戟天100重量份和冰片9重量份。
进一步的,所述的组合物为可制备成药学上可接受的剂型,优选为丸剂或膏剂。
本发明还提供了一种所述的治疗痛经的药物组合物的制备方法,所述的组合物为丸剂,制备方法如下:
(1)取每味中药原料,分别进行消毒灭菌处理;
(2)然后进行粉碎,加入蜂蜜,制成细丸,得到所述的丸剂。
进一步的,步骤(1)中消毒灭菌处理采用大于52°的白酒进行炙制。
在白酒中炙制不仅可以起到消毒灭菌的作用,而且还可以增强药力,将各药物的活性成分提高,采用本发明的炙制方法,得到的组合物治疗痛经的效果更好。
进一步的,步骤(2)中所有中药原料的总质量与蜂蜜的质量比为1:4-5,所述细丸的质量为0.15-0.25g/丸,优选的细丸的质量为0.2g/丸。
本发明的丸剂的服用方法为:经前2-3天开始服药,温开水或姜糖水送服,每天2-3次,每次9-12g,餐前50-60分钟服药。
外用方法:经期疼痛发作时,取药丸3-4g,温开水化开,成浆糊状,将药直接填入肚脐眼(关阕穴),再用外敷贴固定,一般30-40分钟可以止痛。
注意事项:1、不能用凉水服药。2、连续3-4个经前,各服3-5天,不可间断。3、禁食白萝卜、绿豆等反药性的食物。
进一步的,所述的组合物为膏剂,制备方法如下:取除冰片外的中药原料清除杂质,放入温水中浸泡1.5-2.5h,然后大火煮沸,再以小火慢炖,榨汁,浓缩,加入冰片得到所述的膏剂。
进一步的,温水的质量与中药原料总质量之比为2.5-3.5:1,优选的,质量比为3:1,温水的温度为25-35℃。
进一步的,大火煮沸3-7min,小火慢炖80-100min,优选的,大火煮沸5min,小火慢炖90min。
本发明的膏剂的服用方法:成人每天2次,每次120-150ml,早晚空腹时将药膏温热后再服,服药后60-90分钟才能进食。
外用方法:经期疼痛发作时,可以将3-5ml药膏,直接填入肚脐眼(关阕穴),再用外敷贴固定,一般30-40分钟可以止痛。
注意事项:1、可以用高热的姜糖水稀释药膏后再服,但不能冷服。2、连续3-4个经前,各服3-5天,不可间断。3、禁食白萝卜、绿豆等寒凉性的食物。
与现有技术相比,本发明的有益效果为:
(1)本发明的治疗痛经的药组合物以香附、附子、干姜温经;以元胡、乌药行气;以当归、川芎、红花活血;以丹参、冰片化瘀;再以巴戟天、紫石英作用于肾脏,填充经期耗伤的精血,通过温经行气,活血化瘀,便可药到病除,本发明的药物组合物经过各原料的协同作用起到了快速减轻疼痛的作用,且可以治愈痛经,不复发;
(2)本发明的药物组合物即可口服又可外敷使用,人体可以快速吸收,服用30-40min,即可止痛,不添加任何辅料,保持了天然药物的有效成分;
(3)本发明的制备工艺简单,产品方便携带,无其他添加剂,使用安全。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡120g、当归80g、桃仁80g、红花80g、川芎80g、丹参120g、香附120g、附子80g、干姜80g、乌药80g、紫石英80g、巴戟天80g和冰片6g。
本实施例的药物组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在53°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:4,制成细丸,所述细丸的质量为0.15g/丸,得到所述的丸剂。
实施例2
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡145g、当归95g、桃仁95g、红花95g、川芎95g、丹参145g、香附145g、附子95g、干姜95g、乌药95g、紫石英95g、巴戟天95g和冰片8g。
本实施例的药物组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在55°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:4.5,制成细丸,所述细丸的质量为0.2g/丸,得到所述的丸剂。
实施例3
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡100g、当归100g、桃仁100g、红花100g、川芎100g、丹参150g、香附150g、附子100g、干姜100g、乌药100g、紫石英100g、巴戟天100g和冰片9g。
本实施例的药物组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在58°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:5,制成细丸,所述细丸的质量为0.25g/丸,得到所述的丸剂。
实施例1-3的丸剂的服用方法:经前2-3天开始服药,温开水或姜糖水送服,每天2-3次,每次9-12g,餐前50-60分钟服药。
外用方法:经期疼痛发作时,取药丸3-4g,温开水化开,成浆糊状,将药直接填入肚脐眼(关阕穴),再用外敷贴固定,一般30-40分钟可以止痛。
实施例4
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡155g、当归105g、桃仁105g、红花105g、川芎105g、丹参155g、香附155g、附子105g、干姜105g、乌药105g、紫石英105g、巴戟天105g和冰片10g。
本实施例的药物组合物为膏剂,制备方法如下:取除冰片外的中药原料清除杂质,放入25℃的温水中浸泡1.5h,温水的质量与中药原料总质量之比为2.5:1,连药带水放入瓦锅,然后大火煮沸3min,再以小火慢炖80min,榨取药汁,浓缩,加入冰片得到所述的膏剂。
实施例5
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡170g、当归120g、桃仁120g、红花120g、川芎120g、丹参180g、香附180g、附子120g、干姜120g、乌药120g、紫石英120g、巴戟天120g和冰片12g。
本实施例的药物组合物为膏剂,制备方法如下:取除冰片外的中药原料清除杂质,放入35℃的温水中浸泡2.5h,温水的质量与中药原料总质量之比为3.5:1,连药带水放入瓦锅,然后大火煮沸7min,再以小火慢炖100min,榨取药汁,浓缩,加入冰片得到所述的膏剂。
实施例6
本实施例的一种治疗痛经的药物组合物,包括如下原料:元胡100g、当归100g、桃仁100g、红花100g、川芎100g、丹参150g、香附150g、附子100g、干姜100g、乌药100g、紫石英100g、巴戟天100g和冰片9g。
本实施例的药物组合物为膏剂,制备方法如下:取除冰片外的中药原料清除杂质,放入30℃的温水中浸泡2h,温水的质量与中药原料总质量之比为3:1,连药带水放入瓦锅,然后大火煮沸5min,再以小火慢炖90min,榨取药汁,浓缩,加入冰片得到所述的膏剂。
实施例4-6膏剂的服用方法:成人每天2次,每次120-150ml,早晚空腹时将药膏温热后再服,服药后60-90分钟才能进食。
外用方法:经期疼痛发作时,可以将3-5ml药膏,直接填入肚脐眼(关阕穴),再用外敷贴固定,一般30-40分钟可以止痛。
注意事项:1、可以用高热的姜糖水稀释药膏后再服,但不能冷服。2、连续3-4个经前,各服3-5天,不可间断。3、禁食白萝卜、绿豆等寒凉性的食物。
试验例1
选取痛经患者3219人,临床治愈标准为经期不再疼痛,3-5年内不复发为准,服用方法为:患者将实施例3制备的丸剂经前2天开始服药,温开水送服,每天3次,每次9g,餐前50-60分钟服药,直至月经结束,连续用药3个月,效果见表1。
表1
治疗效果 | 有效 | 临床治愈 |
人数 | 2640 | 2092 |
百分率 | 82% | 65% |
本发明人也对其他实施例制备的中药组合物进行了上述的试验,结果基本一致,由于篇幅有限,不再一一列举。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗痛经的药物组合物,其特征在于,按照重量份,包括如下原料:元胡120-170重量份、当归80-120重量份、桃仁80-120重量份、红花80-120重量份、川芎80-120重量份、丹参120-180重量份、香附120-180重量份、附子80-120重量份、干姜80-120重量份、乌药80-120重量份、紫石英80-120重量份、巴戟天80-120重量份和冰片6-12重量份。
2.根据权利要求1所述的一种治疗痛经的药物组合物,其特征在于,按照重量份,包括如下原料:元胡145-155重量份、当归95-105重量份、桃仁95-105重量份、红花95-105重量份、川芎95-105重量份、丹参145-155重量份、香附145-155重量份、附子95-105重量份、干姜95-105重量份、乌药95-105重量份、紫石英95-105重量份、巴戟天95-105重量份和冰片8-10重量份。
3.根据权利要求2所述的一种治疗痛经的药物组合物,其特征在于,按照重量份,包括如下原料:元胡150重量份、当归100重量份、桃仁100重量份、红花100重量份、川芎100重量份、丹参150重量份、香附150重量份、附子100重量份、干姜100重量份、乌药100重量份、紫石英100重量份、巴戟天100重量份和冰片9重量份。
4.根据权利要求1-3任意一项所述的一种治疗痛经的药物组合物,其特征在于,所述的组合物为可制备成药学上可接受的剂型,优选为丸剂或膏剂。
5.一种权利要求4所述的治疗痛经的药物组合物的制备方法,其特征在于,所述的组合物为丸剂,制备方法如下:
(1)取每味中药原料,分别进行消毒灭菌处理;
(2)然后进行粉碎,加入蜂蜜,制成细丸,得到所述的丸剂。
6.根据权利要求5所述的治疗痛经的药物组合物的制备方法,其特征在于,步骤(1)中消毒灭菌处理采用大于52°的白酒进行炙制。
7.根据权利要求5所述的治疗痛经的药物组合物的制备方法,其特征在于,步骤(2)中所有中药原料的总质量与蜂蜜的质量比为1:4-5,所述细丸的质量为0.15-0.25g/丸,优选的,细丸的质量为0.2g/丸。
8.一种权利要求4所述的治疗痛经的药物组合物的制备方法,其特征在于,所述的组合物为膏剂,制备方法如下:取除冰片外的中药原料清除杂质,放入温水中浸泡1.5-2.5h,然后大火煮沸,再以小火慢炖,榨汁,浓缩,加入冰片得到所述的膏剂。
9.根据权利要求8所述的治疗痛经的药物组合物的制备方法,其特征在于,温水的质量与中药原料总质量之比为2.5-3.5:1,优选的,质量比为3:1,温水的温度为25-35℃。
10.根据权利要求8所述的治疗痛经的药物组合物的制备方法,其特征在于,大火煮沸3-7min,小火慢炖80-100min,优选的,大火煮沸5min,小火慢炖90min。
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