CN1092759A - The method for preparing felbamate and its intermediate - Google Patents

The method for preparing felbamate and its intermediate Download PDF

Info

Publication number
CN1092759A
CN1092759A CN93119094.0A CN93119094A CN1092759A CN 1092759 A CN1092759 A CN 1092759A CN 93119094 A CN93119094 A CN 93119094A CN 1092759 A CN1092759 A CN 1092759A
Authority
CN
China
Prior art keywords
ester
ppd
mixture
acid ester
borate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93119094.0A
Other languages
Chinese (zh)
Inventor
D·沃克
C·-H·陈
D·-I·郭
L·J·赫泽格
E·巴巴德
D·J·S·蔡
K·A·贝尔斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avondale Chemical Co Ltd
Original Assignee
Avondale Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avondale Chemical Co Ltd filed Critical Avondale Chemical Co Ltd
Publication of CN1092759A publication Critical patent/CN1092759A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention discloses a kind of felbamate and important intermediate 2-phenyl-1, method of ammediol (PPD) of preparing.By with i) the enolate salt VIII of formyl radical phenylacetic acid ester; ii) E-enol (X); Z-enol (XII) or formyl radical phenylacetic acid ester (XIV); iii) tropate (XIII), iv) tropate borate (XV) or its mixture contact with the borohydride reductive agent of significant quantity with acid, obtain PPD.Another embodiment is, by at random in the presence of acid, cracking V) borate ester (XVI), vi) boric acid ester (XVII) or its mixing also can prepare PPD.By PPD wet or that do, by with (a) cyanate and strong acid or (b) the isocyanic acid chlorine sulfonyl ester reaction in the suitable solvent in non-halogenated solvent, can prepare felbamate (Felbamate).

Description

The method for preparing felbamate and its intermediate
Felbamate (Felbamate), the 2-phenyl-1 shown in the promptly usually said following formula, ammediol diurethanes are the effective anti-epileptic compounds of treatment all kinds epilepsy.
Figure 931190940_IMG14
US 2,884, disclosed felbamate in 444 and 4,978,680.Compound 2-phenyl-1, ammediol (PPD) are the valuable intermediates of preparation felbamate.Yet because also there are problems in the consideration on the production period safety when carrying out industrial-scale production with currently known methods, for example cost is big, and environment and waste treatment problem, productive rate are generally also low.
US 4,982,016(1991), US 5,072,056(1992) and US 5,091,595(1992)) the whole bag of tricks for preparing PPD with phenyl ethyl malonate described.Yet, phenyl ethyl malonate is reduced to the shortcoming of these currently known methodss need of PPD with the reagent that costs an arm and a leg He very easily catch fire (as borane methyl-sulfide and aluminum hydride such as lithium aluminum hydride and diisobutylaluminium hydride).Expensive and the danger of this class reductive agent makes it to be used for industrial-scale production can not be satisfactory.Available US 4,868,327, US 5,091,595 and people such as B.J.Ludwig at J.Med.Chem., Vol.12(3), 1969, the method that discloses among the PP.462-472 is converted into 2-phenyl-1, ammediol diurethanes (felbamate) with undesirable halogenated solvent such as chloroform and halogenated acid such as trifluoroacetic acid and trichoroacetic acid(TCA) on the environment with the PPD of formula (X VIII).
Cause having developed as US 4,868 the rapid method of multistep based on the production PPD of phenyl aldehyde of instructing in 327 for solving all effort that the problems referred to above relevant with the reduction phenyl ethyl malonate carry out.The method that discloses in this document is: being oxidized to phenyl nitromethane, following with formaldehyde reaction with resulting nitrophenyl propylene glycol catalytic reduction by formation benzaldoxime and peracetic acid is PPD, this method has been eliminated all restrictions and the danger that reductive agent discussed above brought, but produce some new danger and cost issues, for example, peracetic acid and nitroparaffins intermediate have the dangerous reaction of potential, even the danger of blast in addition, formaldehyde has been listed the row of carcinogens in, and catalytic hydrogenation has ignition hazard as everyone knows.In addition, US 4,686, and the productive rate of having put down in writing PPD in 327 is low, and several processing step consequent chemical treatment simultaneously and handling problems have caused environmental problem again.
The U.S.S.R(SU on February 25th, 1976) (reduction aldehyde part wherein only, promptly-CHO), then being hydrolyzed prepares the method for tropic acid to have disclosed alkyl ester with alkali-metal borohydride reduction formyl radical toluylic acid in the patent application 322988.This document rear section discloses the method for aldehyde but also ester reduction part of not only reducing.The method of a kind of safety system felbamate and its intermediate PPD preferably is provided, its processing step few in addition than above-mentioned measured step also lack suddenly, the yield height, seldom to form the refuse of unwanted pair of product and disposal or recirculation such as halogenated solvent or halogenated acid and so on less.
The object of the present invention is to provide a kind of preparation 2-phenyl-1, the method for ammediol (PPD) comprises following I), II), III), IV) or VII) compound in every is with the acid and the reaction of borohydride reductive agent of significant quantity, obtain PPD, said compound:
I) the enolate salt (VIII) of formyl radical phenylacetate
Figure 931190940_IMG15
II) E-enol (X), Z-enol (VII) or formyl radical phenylacetate (XI V)
Figure 931190940_IMG16
III) tropate (VIII)
Figure 931190940_IMG17
IV) tropate borate (X V)
Figure 931190940_IMG18
;
VII) above-mentioned I)-IV) mixture, wherein:
M is a positively charged ion, as the periodictable I, and the metal of II or III family, titanium or ammonium; R is cycloalkyl, the alkenyl of alkyl, cycloalkyl, the replacement of alkyl, replacement, alkenyl, cycloalkenyl group, aralkyl, substituted aralkyl, heterocyclic radical, Heterocyclylalkyl, aryl or the substituted aryl of replacement;
X, Y and Z can be independently H ,-OH ,-O-M +,-O-R 2, or-OCOR 2, wherein the definition of M is with above-mentioned identical, R 2Be C -1To C -6Alkyl.
In another embodiment, the object of the present invention is to provide 2-phenyl-1, the preparation method of ammediol (PPD-X VIII) comprises and chooses cracking following compounds in the presence of acid wantonly, obtains PPD:
V) borate ester (X VI)
Figure 931190940_IMG19
VI) boric acid ester (X VII)
Figure 931190940_IMG20
VII) V)-VI) mixture
Wherein:
M is a positively charged ion, for example periodictable I, II or III family metal, titanium or ammonium;
X and Y can be independently H ,-OH ,-O-M +,-O-R 2, or-OCOR 2, the definition of M is the same in addition, R 2Be C -1-C -6Alkyl, its condition are that X and Y can represent the following diester of its structural formula together in the borate ester (X VI):
In this embodiment, can come cracking borate ester (X VI), boric acid ester (X VII) or its mixture by distillation from borate ester (X VI), boric acid ester (X VII) or its mixture or extraction boron portion.In using the distillatory method, adopt transesterification and come the cracking boron portion from the volatility boric acid ester that wherein steams formation.In adopting extracting process, it is the cleavable boron portion that water and suitable organic solvent extract borate ester (X VI), boric acid ester (X VII) or its mixture.
In another embodiment, method of the present invention comprises that also ammediol (PPD) changes 2-phenyl-1 into, the step of ammediol diurethanes (felbamate) the 2-phenyl-1 that obtains from any preparation method of above-mentioned intermediate.
In another embodiment, in formula MA(VI) alkali exists down, and the same manthanoate of phenylacetic acid ester (II) (IV) contact is prepared the enolate salt (VIII) of formyl radical phenylacetic acid ester, and in (IV): M is a positively charged ion, the metal of periodictable I, II or III family for example, titanium or ammonium; A can make MA work to do alkali, obtains the negatively charged ion of the enolate salt (VIII) of formyl radical phenylacetic acid ester.In this embodiment, preferred phenylacetate (II) is a methyl phenylacetate, and said alkali is sodium methylate, and said manthanoate (IV) is a methyl-formiate.
In another embodiment, the invention provides novel boracic intermediate, as tropate borate (X V), borate ester (X VI) and boric acid ester (X VII).
In another embodiment, the present invention also provides a kind of method for preparing felbamate, comprise 2-phenyl-1, ammediol same a) or b) contact:
A) cyanate in non-halogenated solvent and anhydrous gas hydrogenchloride or hydrogen bromide, the rate of felbamate is 70% or higher in the reaction mixture;
B) the isocyanic acid chlorine sulfonyl ester in The suitable solvent.
The other method of preparation felbamate provided by the invention comprises the hydroxyl of PPD is changed into-O-CONH 2, it is characterized in that with the PPD of above-mentioned any method production as starting material.
The method for preparing felbamate and PPD provided by the invention has following advantage: than the productive rate height of other currently known methodss, purity is good; More safer than the method that known technology discloses; Available common processing unit carries out industrial-scale production, and cost is lower, and economy is better; The enolate salt of available formyl radical phenylacetic acid ester is as starting material; These enolate salt can be separated from the reaction mixture for preparing these salt easily, and can store to be used for reaction thereafter; Reduced chemical treatment and handling problems, made and reduce to minimum the harm of environment; Realize that the successive technology mode that said starting material and its intermediate to the conversion of PPD can be suitable for automatic production carries out with high productivity, high like this productivity or automatic production mode can make production cost reduce greatly.
Unless otherwise indicated, wherein listed term definition is as follows:
Alkyl represent has 1-10, the part of the straight chain saturation alkane of preferred 1-6 carbon atom or 3-10, the part of the branched-chain hydrocarbon of preferred 3-6 carbon atom is as methyl, ethyl, propyl group, sec.-propyl, butyl, isobutyl-, the tertiary butyl, amyl group, hexyl, decyl etc.; Term " substituted alkyl " means one or more hydrogen atoms of moieties can be by the alkyl of halogen, hydroxyl, alkyl, aryl or cycloalkyl substituted.
Alkoxyl group is represented by Sauerstoffatom with adjacent structure covalency banded moieties, for example methoxyl group, oxyethyl group, propoxy-, butoxy, hexyloxy etc.
The cycloalkyl representative contains the saturated carbon ring of 3-7 carbon atom, for example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl etc.; Term " cycloalkyl of replacement " means one or more hydrogen atom by the cycloalkyl moiety of halogen, hydroxyl, alkyl, aryl or cycloalkyl substituted;
Alkenyl is represented the straight chain hydrocarbon part of 2-10 the carbon atom that contains at least one carbon-to-carbon double bond or the branched-chain hydrocarbon part of 3-10 carbon atom, as vinyl, 1-propenyl, 1-butylene base, crotyl, isobutenyl, 1-pentenyl, 2-methyl-1-butene thiazolinyl, 1-hexenyl etc.
The aryl representative contains a benzenoid form isocyclic part at least, this ring has all suitable commutable carbon atoms of 6-14 carbon atom aryl base section and this aryl moiety to be possible tie point, as phenyl, naphthyl, indenyl, 2, the 3-indanyl, wherein said isocyclic part can be replaced by 1-3 the group that is independently selected from one group of group being made up of halogen, alkyl, trifluoromethyl, phenyl, hydroxyl, alkoxyl group, phenoxy group, amino, an alkylamino and dialkyl amido arbitrarily; Term " aryl of replacement " mean can by by aryl, alkyl, alkoxyl group, halogen, trihalogenmethyl, cyano group, nitro ,-CONH 2, the aryl moiety that replaces of 1-3 substituting group independently selecting in hydroxyalkyl, sulfydryl or the carboxyl of hydroxyl, hydroxyalkyl, protection of hydroxyl, protection and its salt or the ester;
The aralkyl of aralkyl or replacement means by moieties with the aryl of adjacent structural unit connection or the aryl moiety of replacement, as phenmethyl, 2-chlorobenzene ethyl, 2-anisylethyl etc.;
Hydrochloric ether means one or more hydrogen atom by the hydrocarbon that fluorine, chlorine, bromine or iodine replaced, and chloroform, tetracol phenixin, chlorinated benzene and trifluoromethane then are representatives wherein.
Halogen means fluorine, chlorine, bromine or iodine.
Heterocyclic radical means has an O at least in the carbocyclic ring structure, S and/or N atom insert and have enough numbers not the localization πDian Zi have 2-14, the cyclic group of the aromatic heterocycle of preferred 2-6 carbon atom with what aromatic character was provided, as 2-, 3-or 4-pyridyl, 2-or 3-furyl, 2-or 3-thienyl, 2-, 4-or 5-thiazolyl, 1,2-4-or 5-imidazolyl, 2-, 4-or 5-pyrimidyl, the 2-pyrazinyl, 3-or 4-pyridazinyl, 3-, 5-or 6-[1,2, the 4-triazine] base, 3-or 5-[1,2, the 4-thiadiazoles] base, 2-, 3-, 4-, 5-, 6-or 7-benzofuryl, 1-, 2-, 3-, 4-, 5-, 6-or 7-indyl, 1-, 3,4-or 5 pyrazolyls, 2-, 4-or 5-oxazolyl etc.;
Heterocyclylalkyl means the heterocyclic moiety that connects with adjacent structural unit by moieties.
Boron portion means borate ester (X VI), boric acid ester (X VII) or its mixture of boracic atom, cracking or remove this boron portion and obtain PPD from borate ester (X VI), boric acid ester (X VII) or its mixture.
Method of the present invention and embodiment are described as follows:
In the above-mentioned explanation, M is a positively charged ion, and as the metal in periodictable I, II or the III family, as sodium, potassium, lithium, calcium, magnesium, zinc or aluminium, or M is titanium or ammonium; R is alkyl, alkoxyl group, cycloalkyl, the cycloalkyl of replacement, alkenyl, the alkenyl of replacement, cycloalkenyl group, aralkyl, substituted aralkyl, heterocyclic radical, Heterocyclylalkyl, aryl, the substituted aryl of alkyl, replacement, X, Y and Z be independently H ,-OH ,-O-M +,-O-R 2Or-OCOR 2, M definition herein is the same, R 2Be C 1-6Alkyl.The substituting group of the two keys of wavy line wherein "～～～" expression both can form cis-configuration and also can form transconfiguration.Generally from reaction mixture, do not separate to come during bracket ([]) the expression preparation PPD, but the intermediate that can from reaction mixture, separate.
Aforesaid method can be undertaken by several routes, and in a route (being route A), the enolate salt (VIII) with the formyl radical phenylacetate contacts with acid earlier, obtains PPD with the contact of borohydride reductive agent more thereafter.And in another route (being route B), the enolate salt with formyl radical phenylacetic acid ester contacts with the borohydride reductive agent earlier, and then obtains PPD with the acid contact.In route A and B, preferred enolate salt is 2-formyl radical-2-phenylacetic acid methyl ester sodium salt.In route C, choose wantonly in the presence of acid, tropate (X III) with the borohydride contact, is obtained PPD.In route D, to choose wantonly in the presence of acid, cracking borate ester (X VI) and boric acid ester (X VII) obtain PPD.In above-mentioned each route, preferred acid is sulfuric acid or acetate, and preferred reductive agent is sodium borohydride or POTASSIUM BOROHYDRIDE.
Listed respectively in table 1, table 2 and the table 3 and be suitable for preparing PPD(X VIII) tropate borate (X V), borate ester (X VI) and boric acid ester (X VII).Certainly, these compounds also can form more complicated multi-borate ester class.
Table 1 tropate borate (X V)
Figure 931190940_IMG23
Figure 931190940_IMG24
Figure 931190940_IMG25
The enolate salt (VIII) of formyl radical phenylacetate is contacted the said aldehyde of reduction with the acid of significant quantity with the borohydride reductive agent and ester moiety prepares PPD.These reagent can add by different orders and mix.In a method (being route A), with enolate salt (VIII) but form compound (X), (XII) or (X IV) product that balance exists with suitable acid contact, can advance to separate to it if required.Available hydrogen boride reductive agent is reduced to tropate borate (X V), borate ester (X VI) and boric acid ester (X VII) with these compounds, and cracking borate ester (X VI) and boric acid ester (X VII) obtain the PPD(X VIII of needs subsequently).In other method (being route B), enolate salt (VIII) is mixed with the borohydride reductive agent, and then add acid.In this method, adding acid makes the original place form compound in equilibrium (X), (XII) or (X IV), add borohydride and form tropate borate (X V), borate ester (X VI) and boric acid ester (X VII), change the PPD(X VIII that needs at last into).Use another kind of method, enolate salt, acid and borohydride reductive agent are mixed simultaneously with preparation PPD.All the PPD that obtains in above-mentioned arbitrary method can be converted into felbamate with any currently known methods,, use the chlorine sulfonyl ester and the hydrogenchloride of isocyanic acid or cyanic acid can realize this purpose as exchanging or use method of the present invention with known urethane.
Certainly, before finally changing PPD into, E-enol (X) exists multiple change form (XII) and (X IV) according to solvent for use:
Figure 931190940_IMG26
The solvent of selecting is very big to balance influence.As using dimethyl sulfoxide (DMSO) (DMSO), compound (XII) is preponderated.As use chloroform, above-mentioned three kinds of compounds all exist.
The acid that can be used for the inventive method has any suitable mineral acid, organic acid or its mixture.Suitable mineral acid comprises sulfuric acid, hydrochloric acid, phosphoric acid, boric acid etc.Appropriate organic comprises acetate, citric acid, formic acid, toxilic acid, Tartaric acid, methylsulfonic acid etc.Acid can be pure or with the mixture of organic solvent or water.The acid of available significant quantity makes enolate salt (VIII) protonated, and this weight range preferably waits mole to about 2 equimolar acids/mole enolate salt for waiting mole to surpassing every mole of enolate salt (VIII) approximately approximately.
The borohydride that can be used for the inventive method has sodium, potassium, lithium, calcium, zinc and borohydride magnesium, the borohydride of the modification that the borohydride of preferred sodium or potassium and borohydride make with proton solvent partial reaction.The borohydride reductive agent of available effective base reduces enolate salt (VIII), the aldehyde and the ester moiety of E-enol (X), Z-enol (XII) or formyl radical phenylacetic acid ester (X IV).The consumption of reductive agent is that mole such as every mole of enolate salt (VIII) is to excessive borohydride, the about 2 moles of hydrogen borides of preferably about 1.1-, the more preferably from about about 1.7 moles of hydrogen borides of 1.3-.Term " excessive " means aldehyde and the ester moiety required theoretical amount of the amount of borohydride above reduction enolate salt (VIII) or aldehyde enol (X).
In with the compatible solvent of borohydride reductive agent, implement method of the present invention.This kind solvent comprises protonic solvent, as water, and C 1-10Alcohol, comprise methyl alcohol, ethanol, propyl alcohol, Virahol, butanols etc.Aprotonic solvent comprises first uncle butyl ether and diethyl ether or C just like tetrahydrofuran (THF), toluene, ether 1-5Carboxylicesters such as manthanoate, acetic ester and propionic ester.Also can use the mixture of above-mentioned any solvent, the consumption of solvent should be so that blendable pulpous state reactant can be provided.
This reaction can be carried out to the boiling point of solvent for use at-40 ℃, and preferred-20 ℃ to about 40 ℃, more preferably-15 ℃ to about 30 ℃.Though can carry out this reaction under the environmental stress being higher than, preferably under environmental stress, carry out.
Make reaction mass be arranged sufficiently long duration of contact to finish required reaction, as more than 1-24 hour or 24 hours, preferably about 2-8 hour.
With as extraction, crystallization, filter and/or remove existence any solvent etc. usually recovery method can from reaction mixture, reclaim PPD and other intermediates.
Available suitable carbamate carries out transesterification can change PPD into felbamate.Also can form bischloroformates or PPD and phenyl chloroformate (ph-ococl) reaction and form double manganese ester, then change PPD into felbamate with ammonia treatment again by PPD and carbonyl chloride reaction.
Use method provided by the invention, promptly in non-halogenated solvent, use cyanate or strong acid can make things convenient for and economically PPD be changed into felbamate.The temperature maintenance of reaction mixture is at-20 ℃ of boiling points to reaction mixture, and preferred-15 ℃ to about 50 ℃ approximately, more preferably from about-10 ℃ to about 40 ℃, most preferably from about-5 ℃ extremely about 35 ℃.Suitable cyanate comprises cyanate and the isocyanate with formula (X XII) expression:
T is hydrogen or positively charged ion in the formula, as the periodictable I, the positively charged ions such as metallic cation, titanium or ammonium in II or the III family, n(valence mumber) can be 1-10, the integer of preferred 1-4.Representational cyanate comprises Zassol (NaoCN), potassium cyanate (KOCN), ammonium cyanate (NH 4OCN), cyanic acid magnesium (Mg(OCN) 2), cyanic acid aluminium (Al(OCN) 3) and cyanic acid titanium (Ti(OCN) 4).The amount of the cyanate that every mole of PPD is required is about 2-10 mole, preferably about 2-4 mole, more preferably from about 2-2.5 mole.Suitable strong acid comprises inorganic and organic acid.Strong inorganic acid is hydrochloric acid, Hydrogen bromide, sulfuric acid, nitric acid, perchloric acid and its mixture.Strong organic acid comprises methylsulfonic acid and ArSO 3The aromatic sulfonic acid that H represents, Ar is the phenyl of aryl such as phenyl or replacement in the formula, as tolyl, nitrophenyl, xylyl etc.The amount of the strong acid of every mole of required usefulness of cyanate is to wait about mole to about 2 moles, and preferred about 1.05 to about 1.3 equimolar acids.Preferably contain 50% following water, the more preferably acid of 5% following water.The non-halogenated solvent of this class includes (but are not limited to) N-dialkyl acetamides (C 1-6Alkyl); Acetonitrile; Dimethyl sulfoxide (DMSO) (DMSO); Ether is as glycol dimethyl ether (DME, a glyme), two-(2-methoxy ethyl) ether (diglyme), ethylene glycol diethyl ether and diethoxyethane (DEE).Solvent load is that the amount of effectively dissolving PPD reaction mass is extremely slightly excessive or excessive greatly, and the productive rate of felbamate is about 70% or higher with this understanding.The productive rate of the felbamate in the reaction mixture can be measured with HPLC or with any other suitable method.The comparable ratio that following table has been listed according to reaction mass illustrates the remarkable influence of solvent to the felbamate productive rate.
With new processing method of the present invention, adopt isocyanic ester protection or that shelter also PPD can be converted into felbamate, said isocyanic ester is R 3NCO, wherein R 3Be the blocking group of removing easily, this group is from silyl, as
Figure 931190940_IMG28
In select, or isocyanic acid acyl ester or sulfonyl isocyanate comprise isocyanic acid chlorine sulfonyl ester.Can will need not PPD is further handled or drying still for wet PPD changes felbamate into solvent easily.This can significantly save cost for the automatic production felbamate.
The following examples are used to illustrate embodiments of the present invention, therefore, can not be interpreted as limitation of the scope of the invention.
Embodiment 1
Prepare PPD and felbamate with route A
Figure 931190940_IMG29
I) under 5-10 ℃, the wet cake of the 2-formyl radical that obtains from following preparation example-2-phenylacetic acid methyl ester sodium salt (VIII) is added 300ml 10%(V/V) aqueous sulfuric acid (0.66 angelic acid).Stir this reaction mixture, with ethyl acetate extraction twice, each 150ml.The organic extract liquid that water and saturated brine are combined washs, again with dried over sodium sulfate and filtering.Organic extract liquid is heated at leisure removes any remaining solvent below 50 ℃, obtain 2-formyl radical-2-phenylacetic acid methyl esters (X IV) (oily matter), (X IV) E-enol (X) and Z-enol (XII) are that equilibrated exists in the solution.
II) from the step I) 2-formyl radical-2-phenylacetic acid methyl esters (X IV of obtaining; 26g, 0.146 mole) be dissolved in the 30ml ethanol, under 15-30 ℃ (exterior cooling); be added drop-wise in ethanol (260ml) suspension of sodium borohydride (8.3g, 0.22 mole).This reaction mixture is heated to 50-55 ℃ after about 2 hours,, drips sulfuric acid (200ml, the aqueous solution of 3% V/V) in being lower than under 30 ℃ the temperature.After adding sulfuric acid, this reaction mixture heating 30 minutes, remove ethanol in being lower than under 60 ℃ the temperature vacuum distilling under 50-55 ℃, obtain PPD solution, productive rate is (according to enolate salt starting material meter) more than 90%.Take out remaining product and put into the 200ml ethyl acetate, wash with 100ml water, 100ml saturated sodium bicarbonate and 100ml saturated brine, dried over sodium sulfate, vacuum distilling removes and desolvates.Under 60 ℃, in the 25ml toluene resistates is carried out recrystallization, be cooled to room temperature, to 10 ℃, to filter thereafter then, washing, drying obtain white crystalline 2-phenyl-propane-1,3-glycol (PPD) 14.3g, productive rate 64%, fusing point 54-56 ℃.With ethyl acetate or methyl tert-butyl ether water-bearing mother liquor is extracted continuously with the rate of recovery PPD and to be increased to 90%.
Figure 931190940_IMG30
III) in reaction flask, adds 2-phenyl-1, ammediol (PPD-X VIII) (152.2g, 1 mole) and 760ml toluene.Reflux this reaction mixture to remove any water that exists through Dean-Stark pipe.After stopping heating, reaction mixture temperature is reduced to below 65 ℃, in this reaction flask, add Urethylane (160g, 2.13 mole) and aluminum isopropylate (15.2g, 10%(weight)), heated mixt (about 108 ℃) guarantees that to refluxing the distillation temperature at fractional column top is no more than 65 ℃.Remove toluene after 6 hours, heating is 30 minutes under the reaction mixture vacuum, adds (2 liters, 13 volumes) water in resistates, is heated to 90-95 ℃.Add concentrated hydrochloric acid (11ml, 0.07 volume) in flask, the bottle water (15ml, 0.1 volume) that adds acid is washed, and reaction mixture stirred 30 minutes down at 95 ℃.Remove and to anhydrate (500ml, 3.3 volumes), at room temperature allow the product crystallization.Cooling mixture to 0 ℃ 2 hours filters, and water (1 volume) washing at 30-60 ℃ of following drying products, obtains crude product felbamate (productive rate 87-89%).This crude product (100g) is added in the reaction flask to be further purified adding methyl alcohol (1.2 liters, 12 volumes), being heated to refluxes makes it to form solution, and filtering heat solution is removed part methyl alcohol and made the about 650ml of final volume, mixture is cooled to room temperature, be cooled to 0-5 ℃ about 2 hours, filtering product is with methyl alcohol (100ml, 1 volume) washing, dry under 30-60 ℃, get pure felbamate, productive rate 85%.
Embodiment 2
Prepare PPD with route B
To being housed, overhead stirrer, temperature take into account the 1000ml Virahol of packing in the 3L three-necked flask of condenser that Y-piece props up the feed hopper of commentaries on classics and band nitrogen inlet.Add sodium borohydride (37.9g, 1.0 moles).Be cooled to 10 ℃; under abundant stirring; in this suspension, add α-formyl radical phenylacetic acid methyl esters sodium enolate (100g crude product, the active enolate of 80g, 0.400 mole of activeconstituents); then under the temperature below 30 ℃; slowly drip Glacial acetic acid (60ml, 1.04 moles) meter more than 1 hour, finish Glacial acetic acid after; remove ice bath, stir this reaction mixture under the room temperature and react (measuring) with high performance liquid chromatography (HPLC) until enol sodium.This reaction mixture is heated to 45 ℃ to react until the tropic acid methyl ester intermediate.After reaction mixture is cooled to 10 ℃, slowly add water (250ml).Because the excessive sodium borohydride heat release of quenching, the hydrogen of generation can bubble, so must be careful.Sodium hydroxide with 50% (40ml) transfers to 13 to PH, under 81 ℃, and the air distillation Virahol, distillation is finished, and slurry is cooled to 40 ℃, uses 6NH 2SO 4(290ml) PH is transferred to 4.Measure with HPLC, the PPD productive rate in the solution is greater than 90%.
In reaction paste, add t-butyl methyl ether (200ml), the solution that obtains is transferred in (2 liters) separating funnel.After the layering, water layer merges organic layer with t-butyl methyl ether (300ml) washing.Repeatedly extract from water layer, to reclaim PPD with t-butyl methyl ether.The organic layer that merges precipitates until forming salt of wormwood with 50% solution of potassium carbonate (200ml) washing, vibration.Add entry (60ml) the most of salt of dissolving and make it layering, if necessary, water layer PH is transferred to 11 with 50% solution of potassium carbonate.With rotatory evaporator organic layer simmer down to oily matter, add toluene (50ml) to remove remaining t-butyl methyl ether, solution carries out high vacuum with rotatory evaporator and concentrates, the output 51g(of thick oily matter comprises residual toluene), in this thick oily matter, add toluene (100ml), be heated to 65 ℃, filter the toluene solution of the heat that contains PPD, this solution cool to room temperature, add the PPD crystal seed, cooling kept 30 minutes down at 0 ℃, and the gained wet cake washs with the toluene (50ml) of cold (0-5 ℃), dry under the room temperature, in vacuum drying oven 40-41 ℃, use nitrogen blow-off then, get white crystalline 2-phenyl-propane-1,3-glycol (PPD 40g).Recrystallization gets 38.2g PPD, productive rate 63% for the second time.
Embodiment 3
Prepare 2-phenyl-1, ammediol (PPD) with route B by 2-formyl radical-2-phenylacetic acid methyl ester sodium salt (VIII)
The aqueous solution of the 2-formyl radical that is obtained by preparation example 2-2-phenylacetic acid methyl ester sodium salt (VIII) is cooled to temperature-10 ℃-0 ℃.Slowly add sodium borohydride (3.16kg, 83.4 moles) under the nitrogen atmosphere.Under-10 ℃-0 ℃, add refrigerative Virahol (56 liters).This reaction mixture is cooled to-15 ℃ to-10 ℃.(in 3 hours) add Glacial acetic acid (4.24 liters, 74.1 moles) very slowly.Make 2-formyl radical-2-phenylacetic acid methyl ester sodium salt (VIII) proton turn to the mixture of E-α-hydroxy methylene-phenylacetic acid methyl esters (X), Z-α-hydroxy methylene-phenylacetic acid methyl esters (XII) and formyl radical phenylacetic acid methyl esters (X IV).This mixture (X, XII and X IV) situ converting is tropic acid methyl esters borate (an X V).Temperature maintenance at-15 ℃ to-10 ℃; use the nitrogen protection thermopositive reaction; releasing hydrogen gas; reaction mixture slowly stirred 1 hour; reaction mixture is heated to about 9 ℃; stirring is spent the night, measure with HPLC, by with reaction mixture in the borohydride reaction that exists further make tropic acid methyl esters borate (X V) be converted into the borate ester (X VI) of PPD.In the reaction mixture of boracic hydrochlorate ester (X VI) mixture, add entry (16 liters), PH transferred to about 4.8-5.2, obtain boric acid ester (X VII) and PPD(X VIII with concentrated hydrochloric acid) mixture, measure with proton magnetic resonance (PMR) (NMR) spectrum analysis.This reaction mixture of component distillation is removed Virahol and water, and spissated mixture is cooled to 20 ℃.Contain 2-phenyl-1, ammediol or PPD(X VIII with methyl tertiary butyl ether (each 32 liters) extraction) and the mixture of boric acid ester (X VII) 3 times.The methyl tertiary butyl ether extraction liquid that merges with wet chemical (40%) (each 32 liters) washing 2 times makes boric acid ester (X VII) further be converted into PPD(X VIII).Organic layer with wet chemical washing, is stripped with the salt of wormwood washings that methyl tertiary butyl ether is combined again, contains PPD(X VIII) about 8 liters of the organic layer simmer down tos of merging, to wherein adding 56 liters of toluene.Distillating mixture is removed remaining uncle's butyl ether and water.Filter this enriched mixture down at 60 ℃, then 5 ℃ of coolings down.The PPD of filtering-depositing is with cold toluene wash.Under 30 ℃, in baking oven, carry out drying with nitrogen blow-off, obtain 6.4kg(productive rate 76%, purity+99%) and 2-phenyl-1, ammediol (PPD-X VIII), reclaiming PPD from mother liquor also can further increase productive rate.
Embodiment 4
With tropate (X III) preparation tropate borate (X V)
Figure 931190940_IMG31
In 3 neck reaction flasks, add tropic acid methyl esters (X III, R=CH 3) (1.8g, 0.01 mole) and methylene dichloride (18ml).This mixture is cooled to 0-5 ℃.Under 0-5 ℃, divide and add sodium borohydride (0.38g, 0.01 mole) several times, use the nitrogen protection thermopositive reaction, releasing hydrogen gas.Stirred this reaction mixture 15 minutes down at 0-5 ℃.Under 18 ℃, concentrate this reaction mixture with rotatory evaporator, get solid title tropate borate (X V) 1.08g, productive rate: 96%.
Embodiment 5
Prepare PPD by route C with tropate (X III)
In 3 neck reaction flasks, add tropic acid methyl esters (X III, 10.0g, 0.056 mole) and Virahol (60ml).This mixture is cooled to-5 ℃ to 0 ℃, in said flask, adds sodium borohydride (3.2g, 0.083 mole) preparation tropic acid methyl esters borate (X V, R=CH slowly 3).Slowly add acetate (2.7ml, 0.047 mole) in reaction mixture, obtain the mixture of borate ester (X VI), temperature of reaction is maintained-5 ℃ to 0 ℃, this thermopositive reaction is protected with nitrogen, releasing hydrogen gas.2.5 after hour, under in 5 to 10 ℃, in dense reaction mixture, add Virahol (20ml), in the reaction mixture of boracic hydrochlorate ester (X VI) mixture, add entry (50ml).Use 6NH 2SO 4(5.5ml) PH is transferred to 7.2, obtains boric acid ester (X VII) and PPD(X VIII) mixture.The component distillation reaction mixture is removed Virahol and water.Spissated mixture is cooled to 45 ℃, extracts with propyl carbinol (30ml) down at 40-45 ℃.After being separated, water layer is used propyl carbinol (20ml) extraction again.In the butanols extraction liquid that merges, add 20ml water, use dense H 2SO 4PH is transferred to about 2.0.After the phase-splitting, organic layer water (10ml) washing is the boric acid ester of organic layer simmer down to PPD (X VII) and free PPD(X VIII) mixture.In dense oily matter, add methyl alcohol (40ml), steam methyl alcohol, repeat this step.Remove methyl alcohol and trimethyl borate-methyl alcohol boric acid ester (the X VII Y=OH) becomes free PPD(X VIII) with azeotropic with cracking PPD.Add toluene (60ml), distill this mixture to final volume 30ml to remove remaining first alcohol and water, filter this enriched mixture down at 60 ℃, cool off so that PPD(X VIII down at 10 ℃ to 15 ℃) crystallization, filter this reaction mixture, wash with toluene, under 20 ℃, in vacuum drying oven, use nitrogen blow-off's drying, get 6.1g PPD(X VIII) (productive rate 73%, purity+99%).From mother liquor, reclaim PPD to increase productive rate.
Embodiment 6
By PPD(X VIII) preparation borate diester (X VI)
In 3 neck reaction flasks, add 2-phenyl-1, ammediol (15.21g, 0.1 mole), boric acid (3.09g, 0.05 mole), sodium hydroxide (2.0g, 0.05 mole) and toluene (243.4ml).Reaction mixture refluxes to remove with the Deen-Stark water trap and anhydrates.From then on remove in the alkaline reaction mixture and anhydrate so that balance moves to borate diester (X VI) direction.Be cooled to room temperature afterreaction mixture and filter, use toluene wash, dry in vacuum drying oven under 70 ℃, get title borate diester (X VI) 14.16g(productive rate 80%).
Embodiment 7
In 3 neck reaction flasks, add 2-phenyl-1, ammediol (30.44g, 0.2 mole), boric acid (12.37g, 0.2 mole) and toluene (243.4ml).Reaction mixture is refluxed to remove by the Dean-Stark water trap and anhydrates.From alkaline reaction mixture, remove and anhydrate, balance is moved to boric acid ester (X VII) direction.After being cooled to room temperature, steam toluene, heated mixt is removed remaining toluene under the vacuum.The dense oily matter of gained is cooled to room temperature, gets waxy solid title boric acid ester (X VII) 33.06g, productive rate 93%.
Embodiment 8
Prepare PPD by route D with boric acid ester (X VII)
Figure 931190940_IMG34
In 3 neck reaction flasks, add boric acid ester (X VII, 17.8g, 0.10 mole), methyl alcohol (53.4ml) and H 2SO 4(0.1ml).Component distillation methyl alcohol and trimethyl borate.During the distillation, boric acid ester (X VII) changes PPD(X VIII slowly into), repeat this distillation and be converted into the conversion of PPD greater than the 95%(basis until boric acid ester 1H-NMR analyzes).Add toluene (89.0ml), this mixture distillation to the final volume 70ml to remove remaining methyl alcohol.Mixture in 10-15 ℃ of cooling concentration makes PPD(X VIII) crystallization.Mixture filters the back and uses toluene wash, under 30 ℃, carries out drying with nitrogen blow-off in vacuum drying oven, obtains PPD(X VIII) 14.99g(productive rate 98%).
Embodiment 9
Prepare felbamate with PPD and isocyanic acid chlorine sulfonyl ester
Figure 931190940_IMG35
Under 10-25 ℃, to PPD(3.04g, 0.02 mole) toluene (21ml) suspension in drip toluene (9ml) solution of isocyanic acid chlorine sulfonyl ester (CSI) (5.78g, 0.04 mole), mixture at room temperature stirred 2 hours, and temperature maintenance is being dripped water (25ml) below 50 ℃.Stirred this reaction mixture 30 minutes, be heated to 50 ℃ 20 minutes, be cooled to room temperature, filter, must precipitate crude product felbamate 4.6g(productive rate 96%).
Embodiment 10
A prepares PPD with methyl phenylacetate by route
Under nitrogen atmosphere, sodium methylate (24g, 0.422 mole) is added in the 160ml toluene, then add methyl phenylacetate (40ml, 0.278 mole), mixture heating up is to 40-45 ℃, keep temperature of reaction and under 40-50 ℃ condition, add methyl-formiate (27ml, 0.427 mole).Finish, stirred 30 minutes down in 40-50 ℃, the 2nd adding sodium methylate (4g, 0.070 mole) in this reaction mixture, mixture stirred 30 minutes down at 40-50 ℃.Used the HPLC analyze reaction mixture when finishing in 30 minutes, and showed methyl phenylacetate is converted into 2-formyl radical-2-phenylacetic acid methyl ester sodium salt, transformation efficiency calculates according to the disappearance of phenylacetic acid methyl esters starting material greater than 95%.Unreacted phenylacetic acid methyl esters is lower than 3%.This reaction mixture is cooled to-5 ℃ to 0 ℃, slowly is added in the mixture of the 160ml water of-5 ° of-0 ℃ of precoolings and 40ml propyl carbinol.Reaction vessel washes with 40ml toluene, and washing lotion joins in the mixture of quenching.This reaction mixture is maintained-5 ℃ to 2 ℃.The water that will contain 2-formyl radical-2-phenylacetic acid methyl ester sodium salt rapidly is added to pre-cooled (5 ℃ to 0 ℃) 120ml propyl carbinol and 32ml(0.559 mole) in the mixture of Glacial acetic acid.-5 ℃ under 0 ℃, slowly the organic phase that contains through protonated enolate is added to 200ml propyl carbinol and NaBH 4In the mixture of (16g, 0.422 mole), the temperature maintenance of this thermopositive reaction at-5 ℃-5 ℃.Finish, make reaction mixture to reacting completely with the HPLC monitoring.This reaction mixture is heated to 10-15 ℃.In this reaction mixture, add 20ml methyl alcohol after following 2 hours in 10-15 ℃.Reaction mixture maintains 10-15 ℃ then, carries out the monitoring reaction mixture with HPLC and changes 2-phenyl-1 into until the tropic acid methyl esters, and in the transformation of ammediol (PPD), remaining unreacted tropic acid methyl esters is lower than 3%.This reaction mixture slowly is heated to 25 ℃, slowly adds 320ml water, stirred 5 minutes down at 25 ℃.Use dense H 2SO 4(about 6.5ml) is transferred to PH about 7.2, and the temperature of reaction mixture rises to 40 ℃.After the phase-splitting, water layer is used 80ml n-butanol extraction (the solution productive rate about 90% of PPD) again.In the butanols extraction liquid that merges, add 80ml water, with the dense H of about 1ml 2SO 4PH is transferred to about 2.2, get the mixture of boric acid ester and PPD.After the phase-splitting, organic layer 40ml water washing.Concentrate n-butanol layer, get the oily matter of boracic acid esters PPD mixture.In this oily matter, add methyl alcohol (160ml), concentrate, repeat to distill out 160ml methyl alcohol.Add toluene (200ml), this reaction mixture of component distillation is to volume 160ml under vacuum.Spissated mixture filters about 60 ℃, be stirred to 25 ℃ about 30 minutes.Further the sedimentary PPD of cooling filters, and uses toluene wash down at 0 ℃-5 ℃, under 25 ℃, in vacuum drying oven, be blown into nitrogen and carry out drying, get the productive rate 81% that 32.0g(reclaims product, purity+99.3%) 2-phenyl-1, ammediol, reclaiming PPD from mother liquor increases productive rate.
Embodiment 11
Use PPD, Zassol and hydrogenchloride prepare felbamate
Figure 931190940_IMG36
In flask at the bottom of the 4L three neck gardens that thermometer and mechanical stirrer are housed, add 2-propyl group-1, ammediol (PPD) (152.19g, 1.0 moles) and 760ml anhydrous acetonitrile.Stir down in room temperature (20 ℃).Add Zassol (149.15g, 2.29 moles), cool off this mixture to-5 ℃.With per minute 1300cm 3Speed in mixture, be blown into hydrogen chloride gas 30 minutes, until will about 95g(2.6 mole) HCI sends in the mixture.This high thermopositive reaction is maintained below 35 ℃.With high performance liquid chromatography (HPLC) analyze reaction mixture, the result shows 2-phenyl-1, and ammediol (X VIII) is converted into the transformation efficiency of felbamate (I) greater than 95%.Be left-carbamate alcohol (XX) is less than 2%.This mixture is added in 1.5 premium on currency with this reaction mixture of chilling, and the sodium hydroxide with 10% is this reaction mixture PH that neutralizes 4-6, and mixture heating up to 80 is ℃ until forming transparent solution.Filter this hot solution and be cooled to 10 ℃, filter the gained heterogeneous solution, filter cake is added in 3.4 premium on currency, with 2N hydrochloric acid mixture PH is transferred to 2-2.5, mixture was in 100 ℃ of gentle reflux 5 hours.After the cooling, filter the gained heterogeneous solution, wet cake in 100 ℃ of nitrogen blowing vacuum-dryings, gets 214g(overall yield 90% with 0.5 premium on currency washing 2 times) pure felbamate (purity＞99%).
The preparation starting material
In following explanation, in alkali MX(VI) in the presence of, with the enolate salt (VIII) of the same manthanoate of phenylacetate (II) (IV) contact preparation formyl radical phenylacetic acid ester:
Figure 931190940_IMG37
Wherein:
R is alkenyl, cycloalkenyl group, the aralkyl of cycloalkyl, alkenyl, the replacement of alkyl, cycloalkyl, the replacement of alkyl, replacement, aralkyl, heterocyclic radical, Heterocyclylalkyl, aryl or the substituted aryl of replacement;
R 1Definition and R's is identical, or can form leavings group R 1Other groups of O-such as trimethyl silyl;
M is a positively charged ion, as the metal in periodictable I, II or the III family, titanium or ammonium; With
A can make MA play the negatively charged ion of alkali effect, and said alkali is hydride, alkoxide, acid amides or similar portions.R and R 1Preferable methyl, MA particular methanol sodium.
Phenylacetic acid or formic acid get the two of phenylacetic acid (II) and formic acid (IV), three and four esters with polyvalent alcohol such as glycol, glycerine and tetramethylolmethane esterification.Such ester is suitable for preparing corresponding enolate salt.
In as chemical abstracts (75(a): what disclose 63435q) carries out this method under the condition of the enolate salt (VIII) that effectively generates formyl radical phenylacetic acid ester.In the presence of any suitable organic solvent, implement to prepare the method for enolate salt (VIII).This kind solvent comprises that to used alkali be the inert aprotonic solvent, hydro carbons for example, and as toluene, benzene and dimethylbenzene, or ethers such as ether, methyl tertiary butyl ether etc.Yet, as use alkali, there is no need to require alkali to dissolve in this organic solvent.Suitable alkali comprises: the oxyhydroxide of basic metal and alkaline-earth metal, as sodium hydroxide, potassium hydroxide, calcium hydroxide; Hydride is as sodium hydride or potassium hydride KH; Sodium methylate and potassium tert.-butoxide.
Preparation example 1
2-formyl radical-2-phenylacetic acid methyl ester sodium salt
Figure 931190940_IMG38
In 300ml toluene, add sodium methylate (32.4g, 0.6 mole), remove a spot of first alcohol and water with component distillation.This mixture is cooled to 40-45 ℃, same methyl phenylacetate (45.1g, 0.3 mole) contact.Under 40-45 ℃, mixture was stirred about 10 minutes, add methyl-formiate (19.8g, 0.33 mole).Adding speed by the control methyl-formiate makes the temperature maintenance of this thermopositive reaction be less than or equal to 50 ℃.Carrying out along with reaction forms a large amount of precipitations.When finishing in 2.5 hours; (HPLC) analyzes reaction mixture with high performance liquid chromatography; show that methyl phenylacetate is that 94-95%(calculates according to the methyl phenylacetate starting material that disappears to its productive rate of conversion of 2-formyl radical-2-phenylacetic acid methyl ester sodium salt), remaining unreacted methyl phenylacetate is 5-6%.The solid that filters out, with dry toluene (each 50ml) washed twice, wet cake is used for going on foot down or being less than or equal to 50 ℃ of following vacuum-dryings, is stored in the encloses container.
Preparation example 2
2-formyl radical-2-phenylacetic acid methyl ester sodium salt the aqueous solution
In nitrogen atmosphere, add sodium methylate (VI) (4.74kg, 83.4 moles) in 32 liters of methyl tertiary butyl ethers in 50 gallons of reaction vessels, then add methyl phenylacetate (II) (8 liters, 55.6 moles).Mixture is cooled to 10 ℃, adds methyl-formiate (IV) (4.5 liters, 72.3 moles) lentamente, simultaneously the temperature maintenance of this thermopositive reaction at 10-20 ℃.After adding methyl-formiate (IV); stirred 3 hours down at 25 ℃; when finishing in 3 hours; show with high performance liquid chromatography (HPLC) analyze reaction mixture; methyl phenylacetate calculates according to methyl phenylacetate (II) starting material that disappears greater than 95%(to its productive rate of conversion of 2-formyl radical-2-phenylacetic acid methyl ester sodium salt (VIII)), remaining unreacted methyl phenylacetate is 3%.This reaction mixture is cooled to-5 ℃, slowly adds cold water (24 liters), temperature maintenance stirred 10 minutes down at 0 ℃.Place after 15 minutes, mixture is divided into organic phase and water, and water contains 2-formyl radical-2-phenylacetic acid methyl ester sodium salt (VIII).

Claims (23)

1, a kind of preparation 2-phenyl-1, the method for ammediol (PPD-X VIII) comprising: with I), II), III), IV) compound or its mixture obtain PPD with the acid and the reaction of borohydride reductive agent of significant quantity, said compound is:
I) the enolate salt (VIII) of formyl radical phenylacetic acid ester
Figure 931190940_IMG1
II) E-enol (X), Z-enol (XII) or formyl radical phenylacetic acid ester (X IV)
Figure 931190940_IMG2
III) tropate (X III) (X III)
IV) tropate borate (X V)
Figure 931190940_IMG4
Wherein:
M is a positively charged ion;
R is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl base, cycloalkenyl group, aralkyl, substituted aralkyl, heterocyclic radical, Heterocyclylalkyl, aryl or substituted aryl;
X, Y and Z can be independently H ,-OH ,-O-M +,-O-R 2Or-OCOR 2, this M definition is the same, R 2Be C 1-6Alkyl.
2, the process of claim 1 wherein that said enolate salt (VIII) is 2-formyl radical-2-phenylacetic acid methyl ester sodium salt.
3, the process of claim 1 wherein that said reaction agent compounds is an II) E-enol (X), Z-enol (XII) or formyl radical phenylacetic acid ester (X IV) or its mixture.
4, the process of claim 1 wherein that said reaction agent compounds is an III) tropate (X I I I).
5, the process of claim 1 wherein that said reaction agent compounds is an IV) tropate borate (X V).
6, the process of claim 1 wherein that said acid is sulfuric acid or acetate, said borohydride also agent is sodium borohydride or potassium borohydrid.
7, a kind of preparation 2-phenyl-1, the method for ammediol (PPD-X VIII) comprises cracking compound V), VI) or its mixture, obtain PPD, said compound:
V) borate ester (X VI)
Figure 931190940_IMG5
VI) boric acid ester (X VII)
Wherein:
M is a positively charged ion;
X and Y can be independently H ,-OH ,-O -M +,-O-R 2Or-OCOR 2, M definition herein is the same, R 2Be C 1-6Alkyl, its condition are in borate ester (X VI), but X and the Y following diester of representative structure formula together:
Figure 931190940_IMG7
8, the method for claim 7, wherein cracking borate ester (X VI) or boric acid ester (X VII) in the presence of acid.
9, claim 7 or 8 method are wherein with extraction and/or with distilling cracking borate ester (X VI), boric acid ester (X VII) or its mixture
10, the method for claim 7-9, wherein water or suitable organic solvent extraction be with cracking borate ester (X VI), boric acid ester (X VII) or its mixture.
11, the method for claim 7-9 is wherein used hydrolysis and transesterification mixture, therefrom distills the volatility boric acid ester of removing formation subsequently and comes cracking borate ester (X VI), boric acid ester (X VII) or its mixture.
12, the method for claim 1-11, wherein the 2-phenyl-1 that makes like this, ammediol (PPD-X VIII) is converted into 2-phenyl-1, ammediol diurethanes (felbamate-1).
13, the method for claim 1-2, wherein, in the presence of the alkali MA of (VI) representative; enolate salt (VIII) with the same manthanoate of phenylacetate (II) (IV) contact preparation formyl radical phenylacetic acid ester; in (VI), M is a positively charged ion, and A can make MA play the negatively charged ion of alkali effect.
14, the method for claim 13, wherein said phenylacetic acid ester (II) is the phenylacetic acid methyl esters, and said alkali is sodium methylate, and said manthanoate (IV) is a methyl-formiate.
15, the tropate borate (X V) that has following structural formula:
Figure 931190940_IMG8
Wherein: X and Y represent independently H ,-OH,
Figure 931190940_IMG9
,-O-R 2Or OCOR 2, M is a positively charged ion,
R 2Be C 1-6Alkyl and
R is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl base, cycloalkenyl group, aralkyl, substituted aralkyl, heterocyclic radical, Heterocyclylalkyl, aryl or substituted aryl.
16, the borate ester (X VI) that has following structural formula:
Figure 931190940_IMG10
Wherein: X and Y be independently H ,-OH ,-O -M +,-O-R 2Or OCOR 2, this M is a positively charged ion, R 2Be C 1-6Alkyl; Or X and Y represent the diester with following structural formula together:
Figure 931190940_IMG11
17, have following structural formula boric acid ester ((X VII):
Figure 931190940_IMG12
Wherein: Y is-OH ,-OM +, O-R 2Or-OCOR 2, this M is the metal of periodictable I, II or III family, R 2Be C 1-6Alkyl.
18, the boric acid ester of claim 17 (X VII), wherein Y is-OH.
19, the boric acid ester of claim 18 (X VII), wherein Y is-OR 2, R 2Be C 1-6Alkyl or
Figure 931190940_IMG13
20, boric acid ester (X VII), wherein Y is-OCOR 2
21, a kind of method for preparing felbamate comprises 2-phenyl-1, ammediol same a) or b) contact: said
A) isocyanic ester in non-halogenated solvent and strong acid, the productive rate that felbamate can be provided are about 70% or higher;
B) the isocyanic acid chlorine sulfonyl ester in The suitable solvent.
22, the method for claim 21, wherein said solvent are glycol dimethyl ether, acetonitrile, N,N-dimethylacetamide or its mixture.
23, a kind of method for preparing felbamate comprises that the hydroxyl with PPD changes into-OCONH 2, it is characterized in that preparing the PPD that is used as starting material with each method among the claim 1-11.
CN93119094.0A 1992-09-18 1993-09-15 The method for preparing felbamate and its intermediate Pending CN1092759A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94731292A 1992-09-18 1992-09-18
US947,312 1992-09-18
US6507593A 1993-05-25 1993-05-25
US065,075 1993-05-25

Publications (1)

Publication Number Publication Date
CN1092759A true CN1092759A (en) 1994-09-28

Family

ID=26745178

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93119094.0A Pending CN1092759A (en) 1992-09-18 1993-09-15 The method for preparing felbamate and its intermediate

Country Status (4)

Country Link
CN (1) CN1092759A (en)
AU (1) AU5159393A (en)
IL (1) IL107002A0 (en)
WO (1) WO1994006737A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104151340A (en) * 2014-07-30 2014-11-19 河南师范大学 Preparation method of dipyrazolyl borate-K[(C3N2H3)2BC8H14]

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60003791T2 (en) * 1999-02-09 2004-02-05 The University Of Virginia Alumni Patents Foundation Felbamate DERIVATIVES
TWI372725B (en) * 2004-01-30 2012-09-21 Semequip Inc Methods of synthesis of isotopically enriched borohydride and methods of synthesis of isotopically enriched boranes
US7884227B2 (en) 2007-10-26 2011-02-08 Navinta Llc Felbamate with improved bulk density
WO2012032508A1 (en) 2010-09-07 2012-03-15 Taro Pharmaceutical Industries Ltd. Process for the preparation of 2-phenyl-1,3-propanediol
IT202000011626A1 (en) 2020-05-19 2021-11-19 Consorzio Interuniversitario Naz Per La Reattivita’ Chimica E La Catalisi PROCESS FOR THE PREPARATION OF POLYURETHANE FREE FROM ISOCYANATES BY CO-POLYMERIZATION OF DIOLS WITH UREA IN THE PRESENCE OF METALLIC OXIDES AS CATALYST

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU322988A1 (en) * 1970-06-18 1976-02-25 Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе The method of obtaining tropic acid
JPS4936653A (en) * 1972-08-08 1974-04-05
US5091595A (en) * 1989-06-07 1992-02-25 Choi Young M Reduction of diethyl phenylmalonate to 2-phenyl-1,3-propanediol
US5239121A (en) * 1992-09-16 1993-08-24 Ganes Chemicals Inc. Process for the preparation of 2-aryl-1,3-propanediols

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104151340A (en) * 2014-07-30 2014-11-19 河南师范大学 Preparation method of dipyrazolyl borate-K[(C3N2H3)2BC8H14]

Also Published As

Publication number Publication date
AU5159393A (en) 1994-04-12
IL107002A0 (en) 1993-12-28
WO1994006737A1 (en) 1994-03-31

Similar Documents

Publication Publication Date Title
CN1025612C (en) Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity
TWI631121B (en) Processes for the preparation of an apoptosis-inducing agent
CN106928227B (en) Synthetic method of entecavir and intermediate compound thereof
CN1759093A (en) Azide free process for preparing 1,2-diamino compounds
CN111465402A (en) Compounds and synthetic methods for the preparation of retinoid X receptor-specific retinoids
CN1870998A (en) CCR-2 antagonist salt
CN1178921C (en) Preparation of sulfonamides
FR2697522A1 (en) Process for the preparation of taxane derivatives.
WO2016002918A1 (en) Method for producing indole compound
CN1092759A (en) The method for preparing felbamate and its intermediate
CN111153869A (en) Method for preparing oxazole compound
EP0599973A1 (en) Process for the preparation of beta-phenylisoserine derivatives and use thereof
CN1070403A (en) New-beta-carboline derivatives and preparation and medicinal application
CN1173928C (en) Process for preparing (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof
US20100145099A1 (en) Novel polymorphic forms of milnacipran hydrochloride
CN1242971C (en) Method of producing reduced coenzyme Q10 as oily product
CN102875421A (en) Aziridine compound loop opening method based on p-nitrobenzoic acid
US10562834B2 (en) Process for preparing substituted crotonic acids
JPH07145083A (en) Decarboxylation method
JP6963435B2 (en) Method for producing intermediate of biotin and method for producing biotin
TW200405809A (en) Process for preparing (S)-(+)-2-(substituted phenyl)-2-hydroxy-ethyl carbamates
CA2403230A1 (en) Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors
JP4030289B2 (en) Process for producing β-ketonitriles
JP2006312644A (en) METHOD FOR PRODUCING beta-KETONITRILES
CN107556237B (en) Preparation method of 3- (2-phenethyl) -2-pyridine carboxamide compound

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication