CN109261232A - It is a kind of can the integrated microfluidic control method of on piece and microvalve device - Google Patents
It is a kind of can the integrated microfluidic control method of on piece and microvalve device Download PDFInfo
- Publication number
- CN109261232A CN109261232A CN201811367032.XA CN201811367032A CN109261232A CN 109261232 A CN109261232 A CN 109261232A CN 201811367032 A CN201811367032 A CN 201811367032A CN 109261232 A CN109261232 A CN 109261232A
- Authority
- CN
- China
- Prior art keywords
- microchannel
- micro
- pdms
- draw runner
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Abstract
The invention discloses one kind can the integrated microfluidic control method of on piece and microvalve device.This method is that draw runner is arranged above PDMS substrate, when draw runner is moved to above the microchannel PDMS, draw runner squeezes the microchannel PDMS, make the deformation of the microchannel PDMS, microfluid is hindered to pass through, micro-valve is closed, when draw runner moves away on the outside of the microchannel PDMS, microchannel restores to the original state, and microfluid normally circulates, and micro-valve is opened.The present invention can operate microfluidic device without any change and destruction, may be implemented to integrate in piece completely, design without complicated micro-valve unit, and cost is extremely low, easy to operate, be suitble to micro-fluidic system application.The present invention provides the microvalve device that can be controllably integrated on pcb board for micro-analysis system, significantly reduction detection system space, is highly suitable for micro-fluidic system detection, provides a kind of microfluidic manipulations component of key for micro-analysis system.
Description
Technical field
The present invention relates to the microvalve device and method that microfluid transports is controlled in a kind of micro-fluidic chip, more particularly, to one
Kind can the integrated microvalve device of on piece and microfluidic control method completely, belong to microfluidic art.
Background technique
Relatively traditional laboratory analysis methodologies, on piece microflow analysis is few, small in size with reagent consumption, analyzes speed
Fastly, the advantages that error of manual operation introducing can be reduced, it is widely used in DNA analysis, protein analysis, unicellular point
The fields such as analysis, drug screening, food safety, illicit drugs inspection and environmental monitoring, and gradually go deep into people's social life every aspect.
Micro-valve is component units indispensable in microfluidics, it determines in microfluidics that miniflow transports direction and micro-
The distribution of fluid product, therefore, research have the social value and academic significance of reality for the micro-valve of microfluidics.
In recent years, domestic and international expert, scholar have put into a large amount of energy and financial resources, have developed for the micro- of microflow analysis
Valve, wherein especially more deep, thorough with the research of active micro valve.
The Andreas Manz research team of Switzerland is the pioneer for being engaged in micro-valve research in microchannel, they realize earliest
Microchannel electroendosmosis micro-valve makes electroosmotic flow in capillary electrophoresis system rapidly turn to another channel from a channel.Then, the U.S.
The J.Michael Ramsey research group of Tennessee State Oak Ridge National Laboratory improves electric osmose micro-valve, only with one
A voltage source and three sample cells realize the microfluidic circuit control of sample flow and buffer.On this basis, U.S. Sen Diya state
The addressable electronic micro-valve of voltage has been invented by laboratory microfluid research department of family, the switch motion of PLC technology micro-valve, greatly
Ground improves the simplicity of microfluidic circuit controllability and microfluidic manipulations.The advantages of electronic micro-valve be switch response speed it is very fast, but
There is also some defects for it: electronic micro-valve is influenced greatly by microchannel surface characteristic；It is influenced seriously by buffer ion component；It needs
Hundreds of volts of voltage sources are up to, increase microflow analysis cost, and bring security risk to operator.Therefore, electronic micro-
Valve is only applicable to such as electrocapillary phoresis specific occasion.
To reduce electronic micro-valve supply voltage value, electrostatic micro-valve method is proposed, supply voltage needed for micro-valve is reduced to
Some tens of volts is applied successfully to low-pressure air current control.But electrostatic micro-valve uses rigid silicon fiml mostly, and micro-valve manufacture craft is more
Complexity, and voltage needed for micro-valve is still higher.
Magnetic micro-valve can solve electronic micro-valve above-mentioned the shortcomings that referring to, it is a kind of using externally-applied magnetic field as the active of driving source
Micro-valve, typical structure are that iron powder is mixed in the dimethyl silicone polymer (PDMS), using the v-shaped cavity after anisotropic etching as
Valve plug and valve plug bracket, in externally-applied magnetic field, valve plug and bracket are lifted, and valve is opened.For improve electromagnetic micro valve electromagnetic force,
Often the permanent-magnet materials such as electromagnetic coil are embedded in electromagnetic micro valve, reach the closing forces of electromagnetic micro valve in 0.25mA
0.8mN closes solenoid valve to reliably tilt valve seat upper diaphragm.Since electromagnetic micro valve needs mobile additional electromagnetic field, operation
It is convenient not as good as electronic micro-valve in integration.Simultaneously as insertion permanent-magnet material, the integration of micro-valve also correspondingly decline, magnetic
Road is also more complex, higher cost, is not suitable for fully-integrated in piece.Other active micro valves such as hot gas expansion driven micro-valve, bimetallic
Driving micro-valve and shape memory micro-valve is the thermal drivers micro-valve of representative, and using heat driven heated material, deformation occurs, drive every
Micro-valve movement is realized in film inclination.Such micro-valve mostly uses greatly mechanical part, increases the difficulty applied on micro flow chip, and
Power consumption is larger.
To solve above-mentioned micro-valve disadvantage, the microvalve device for not needing external connection power source is had been reported that, it can be achieved that on piece complete set
At.Such as, 224-230 pages of the phase of periodical " sensor and actuator " 2017 volume 265 the 9th, which discloses, uses polylactic acid one end
Puncher perforation, by one end perforation polylactic acid insertion dimethyl silicone polymer micro flow chip on, perforation eat dishes without rice or wine height with
Microchannel height is consistent on dimethyl silicone polymer micro flow chip, and micro flow chip is fixed on a glass substrate, when polylactic acid turns
Microchannel both ends are engaged by polylactic acid when moving consistent with two mouthfuls of microchannel to two mouths, realize that miniflow passes through, real
Existing micro-valve conducting；When rotation polylactic acid makes its through-hole and not consistent microchannel mouthful, polylactic acid two sides microchannel is not led
It is logical, realize that micro-valve is closed.This method can effectively realize micro-valve on piece integration problem, but due to being realized by the empty lactic acid stick of rotation band
Miniflow transports and ends, and needs to perforate to microchannel, destroys micro flow chip structure, increases processing step, and micro-valve
Leakage pressure is lower, and durability is also to be improved.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of structure is simple, leakage pressure is higher, and durability is good, can on piece collection
At micro-valve device and microfluidic control method.
The present invention adopts the following technical scheme:
The present invention provide it is a kind of can the integrated microfluidic control method of on piece, draw runner is set above PDMS substrate, works as draw runner
When being moved to above the microchannel PDMS, draw runner squeezes the microchannel PDMS, makes the deformation of the microchannel PDMS, and microfluid is hindered to pass through, micro-
Valve is closed, and when draw runner moves away on the outside of the microchannel PDMS, microchannel restores to the original state, and microfluid normally circulates, and micro-valve is opened.
The present invention also provides it is a kind of can the integrated microvalve device of on piece, including substrate, PDMS substrate, microchannel, slideway,
Draw runner, the PDMS substrate fit on substrate, and microchannel is provided at PDMS substrate, and the slideway is set to microchannel
Top, the draw runner are moved along microchannel, and when draw runner moves to above the microchannel for needing to control, draw runner squeezes PDMS
Microchannel makes the deformation of the microchannel PDMS.
Further, one end of the draw runner is limited in slideway, and the end face of the other end is arcwall face.
Further, the bottom end of the arcwall face is higher than microchannel top 0.3-1mm.
Further, the quantity of the draw runner is n, wherein n=1,2,3 ... ....
Further, the substrate is pcb board.
Further, the slideway is set to above microchannel by bracket, and the bracket is fixed on substrate.
Compared with the prior art, the advantages of the present invention are as follows:
Without destroying micro flow chip structure, it can be achieved that fully-integrated in piece, micro flow chip is fitted on pcb board, is passed through
Suspension springs press microchannel, so that deformation occurs for microchannel to realize micro-valve switch operation, can be integrated in outer detecting circuit
On same pcb board, reduce detection system space significantly, is highly suitable for micro-fluidic system detection.
Detailed description of the invention
Fig. 1 is that the present invention can the integrated microvalve device schematic diagram of on piece.
Marked in the figure: 1, pcb board；2, PDMS substrate material；3, the first input port；4, draw runner；5, the second input port；6, sliding
Road；7, bracket；8, it exports；9, microchannel.
Specific embodiment
The present invention will be described in further detail below with reference to the embodiments of the drawings.
The present invention places draw runner above the microchannel PDMS, and when draw runner is moved to below the microchannel PDMS, draw runner is squeezed
The microchannel PDMS makes its deformation, and microfluid is hindered to pass through, and micro-valve is closed.When draw runner moves away on the outside of microchannel, microchannel is extensive
Shape is restored, microfluid normally circulates, and micro-valve is opened.The present invention provided for micro-analysis system can controllably be integrated in it is micro- on pcb board
Valve gear, significantly reduction detection system space, are highly suitable for micro-fluidic system detection.For micro-analysis system provide it is a kind of key
Microfluidic manipulations component.
Embodiment one
The present embodiment provides a kind of as shown in Figure 1 can the integrated microvalve device of on piece.There are two defeated to have for the present embodiment
It is described in detail for the microfluidic device of entrance and a delivery outlet microchannel.
The present embodiment can the integrated microvalve device of on piece structure as shown in Figure 1, including that substrate, PDMS substrate 2 are (i.e. poly-
The substrate of dimethyl siloxane material), microchannel 9, slideway 6, draw runner 4, the microchannel 9 of this implementation includes the first input port
3, the second input port 5 and delivery outlet 8.The PDMS substrate 2 fits on substrate, and microchannel 9 is provided at PDMS substrate 2,
Slideway 6 is set to the top of microchannel 9, and the draw runner 4 is moved along microchannel 9, when draw runner 4 move to needs control it is micro-
When 9 top of circulation road, draw runner 4 squeezes the microchannel PDMS, makes the deformation of the microchannel PDMS.
Aforesaid substrate is preferably pcb board 1, and 1 one side of pcb board is used to support PDMS micro element, on the other hand for fixing
Litter bracket additionally can realize automatic control and detection circuit by integrated electronic circuit on it.
Preferably, one end of the draw runner 4 is limited in slideway 6, and the end face of the other end is arcwall face.The bottom end of arcwall face
Preferably higher than 0.3-1mm is pushed up in microchannel.When greater than 0.3mm, PDMS deformation can be such that the microchannel of common 100 micron diameter sends out
It is raw to block, when more than 1mm, there is certain drag effect when draw runner moves to above microchannel.
Draw runner 4 can move on slideway 6, and when being moved to above microchannel, the arch section of draw runner lower end squeezes PDMS,
So that microchannel deformation, realizes that microchannel is closed, that is, realizes micro-valve closing function.When draw runner shifts to microchannel outside, microchannel
Restore conducting, realizes that micro-valve is opened.Two channel selectivities switch can be realized by draw runner position, two cunnings also can be set
Item can be realized simultaneously various microchannels and open and close.
The present invention can operate microfluidic device without any change and destruction, may be implemented to integrate in piece completely,
It being designed without complicated micro-valve unit, cost is extremely low, and it is easy to operate, it is suitble to micro-fluidic system application.The present invention is micro-analysis system
The microvalve device that can be controllably integrated on pcb board is provided, significantly reduction detection system space, is highly suitable for micro-fluidic system inspection
It surveys.A kind of microfluidic manipulations component of key is provided for micro-analysis system.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention.It is all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (7)
1. one kind can the integrated microfluidic control method of on piece, it is characterised in that: draw runner is arranged above PDMS substrate, when draw runner moves
When moving above the microchannel PDMS, draw runner squeezes the microchannel PDMS, makes the deformation of the microchannel PDMS, hinders microfluid to pass through, micro-valve
It closes, when draw runner moves away on the outside of the microchannel PDMS, microchannel restores to the original state, and microfluid normally circulates, and micro-valve is opened.
2. one kind can the integrated microvalve device of on piece, it is characterised in that: including substrate, PDMS substrate, microchannel, slideway, cunning
Item, the PDMS substrate fit on substrate, and microchannel is provided at PDMS substrate, and the slideway is set on microchannel
Side, the draw runner are moved along microchannel, and when draw runner moves to above the microchannel for needing to control, it is micro- that draw runner squeezes PDMS
Channel makes the deformation of the microchannel PDMS.
3. one kind according to claim 2 can the integrated microvalve device of on piece, it is characterised in that: one end of the draw runner limits
In slideway, the end face of the other end is arcwall face.
4. one kind according to claim 3 can the integrated microvalve device of on piece, it is characterised in that: the bottom end of the arcwall face
0.3-1mm is pushed up higher than microchannel.
5. one kind according to claim 2 can the integrated microvalve device of on piece, it is characterised in that: the quantity of the draw runner is
N is a, wherein n=1, and 2,3 ... ....
6. one kind according to claim 2 can the integrated microvalve device of on piece, it is characterised in that: the substrate is pcb board.
7. one kind according to claim 2 can the integrated microvalve device of on piece, it is characterised in that: the slideway passes through bracket
It is set to above microchannel, the bracket is fixed on substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811367032.XA CN109261232A (en) | 2018-11-16 | 2018-11-16 | It is a kind of can the integrated microfluidic control method of on piece and microvalve device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811367032.XA CN109261232A (en) | 2018-11-16 | 2018-11-16 | It is a kind of can the integrated microfluidic control method of on piece and microvalve device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109261232A true CN109261232A (en) | 2019-01-25 |
Family
ID=65190436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811367032.XA Pending CN109261232A (en) | 2018-11-16 | 2018-11-16 | It is a kind of can the integrated microfluidic control method of on piece and microvalve device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109261232A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109946423A (en) * | 2019-02-28 | 2019-06-28 | 南京普特保仪器有限公司 | A kind of micro-fluidic automatic sampling reactor |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1645141A (en) * | 2005-01-20 | 2005-07-27 | 上海交通大学 | Polydimethylsiloxane based microorgan reagent analyzing and testing chip |
| CN101617155A (en) * | 2006-12-15 | 2009-12-30 | 麦克罗斯塔克公司 | Microvalve device |
| CN102124259A (en) * | 2008-05-16 | 2011-07-13 | 哈佛大学 | Valves and other flow control in fluidic systems including microfluidic systems |
| CN103341370A (en) * | 2008-10-28 | 2013-10-09 | 藤仓化成株式会社 | Liquid passage device and manufacturing method |
| CN104180015A (en) * | 2014-07-07 | 2014-12-03 | 宁波大学 | Micro valve and method for controlling transport of fluid by virtue of micro valve |
| US9321051B2 (en) * | 2009-12-22 | 2016-04-26 | Samsung Electronics Co., Ltd. | Microfluidic device and method of manufacturing the same |
| CN105570531A (en) * | 2016-03-08 | 2016-05-11 | 清华大学深圳研究生院 | Micro-fluidic chip flow adjusting system and method |
| CN106015728A (en) * | 2016-06-08 | 2016-10-12 | 常州工学院 | Surface acoustic wave controlled shape memory alloy microvalve and control method thereof |
| CN106031889A (en) * | 2016-05-17 | 2016-10-19 | 西安交通大学 | Rapid protein detection system based on centrifugal platform |
| CN106163978A (en) * | 2014-09-15 | 2016-11-23 | 蔚山科学技术院 | The control equipment of micro flow unit and micro flow unit |
| CN106247006A (en) * | 2016-09-19 | 2016-12-21 | 宁波大学 | A kind of micro-valve of marmem based on surface acoustic wave and control method thereof |
| CN108139419A (en) * | 2015-10-23 | 2018-06-08 | 国立研究开发法人科学技术振兴机构 | Nanofluidic devices and chemical analysis device |
-
2018
- 2018-11-16 CN CN201811367032.XA patent/CN109261232A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1645141A (en) * | 2005-01-20 | 2005-07-27 | 上海交通大学 | Polydimethylsiloxane based microorgan reagent analyzing and testing chip |
| CN101617155A (en) * | 2006-12-15 | 2009-12-30 | 麦克罗斯塔克公司 | Microvalve device |
| CN102124259A (en) * | 2008-05-16 | 2011-07-13 | 哈佛大学 | Valves and other flow control in fluidic systems including microfluidic systems |
| CN103341370A (en) * | 2008-10-28 | 2013-10-09 | 藤仓化成株式会社 | Liquid passage device and manufacturing method |
| US9321051B2 (en) * | 2009-12-22 | 2016-04-26 | Samsung Electronics Co., Ltd. | Microfluidic device and method of manufacturing the same |
| CN104180015A (en) * | 2014-07-07 | 2014-12-03 | 宁波大学 | Micro valve and method for controlling transport of fluid by virtue of micro valve |
| CN104180015B (en) * | 2014-07-07 | 2016-07-27 | 宁波大学 | A kind of micro-valve and utilize this micro-valve to control the method that transports of microfluid |
| CN106163978A (en) * | 2014-09-15 | 2016-11-23 | 蔚山科学技术院 | The control equipment of micro flow unit and micro flow unit |
| CN108139419A (en) * | 2015-10-23 | 2018-06-08 | 国立研究开发法人科学技术振兴机构 | Nanofluidic devices and chemical analysis device |
| CN105570531A (en) * | 2016-03-08 | 2016-05-11 | 清华大学深圳研究生院 | Micro-fluidic chip flow adjusting system and method |
| CN106031889A (en) * | 2016-05-17 | 2016-10-19 | 西安交通大学 | Rapid protein detection system based on centrifugal platform |
| CN106015728A (en) * | 2016-06-08 | 2016-10-12 | 常州工学院 | Surface acoustic wave controlled shape memory alloy microvalve and control method thereof |
| CN106247006A (en) * | 2016-09-19 | 2016-12-21 | 宁波大学 | A kind of micro-valve of marmem based on surface acoustic wave and control method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109946423A (en) * | 2019-02-28 | 2019-06-28 | 南京普特保仪器有限公司 | A kind of micro-fluidic automatic sampling reactor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Qian et al. | Actuation mechanism of microvalves: A review | |
| Au et al. | Microvalves and micropumps for BioMEMS | |
| Zhang et al. | Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends | |
| Oh et al. | A review of microvalves | |
| Shikida et al. | Using wettability and interfacial tension to handle droplets of magnetic beads in a micro-chemical-analysis system | |
| Tai et al. | Automatic microfluidic platform for cell separation and nucleus collection | |
| US9829451B2 (en) | Microfluidic reconfiguration device for multi-plexed sample analysis | |
| CN102341691A (en) | Instrument with microfluidic chip | |
| Sedgwick et al. | Lab-on-a-chip technologies for proteomic analysis from isolated cells | |
| CN103335154B (en) | A kind of electromagnetic micro valve be integrated on micro-fluidic chip | |
| US20060073540A1 (en) | Method and system for controlling micro-objects or micro-particles | |
| Jeon et al. | Electrical force-based continuous cell lysis and sample separation techniques for development of integrated microfluidic cell analysis system: A review | |
| CN206637105U (en) | A kind of electromagnetic micro valve for micro-fluidic chip | |
| CN102876563B (en) | Micro- fluid control chip capable of automatically catching single cells | |
| Gholizadeh et al. | Magnetically actuated microfluidic transistors: Miniaturized micro-valves using magnetorheological fluids integrated with elastomeric membranes | |
| Sun et al. | Design, simulation and experiment of electroosmotic microfluidic chip for cell sorting | |
| Li et al. | Microvalve using electrokinetic motion of electrically induced Janus droplet | |
| CN206592627U (en) | A kind of electromagnetic micro valve for being integrated in micro-fluidic chip | |
| CN109261232A (en) | It is a kind of can the integrated microfluidic control method of on piece and microvalve device | |
| WO2017156085A1 (en) | Microfluidic particle sorter | |
| Baek et al. | A wireless sequentially actuated microvalve system | |
| Arakawa et al. | Three-dimensional sheath flow sorting microsystem using thermosensitive hydrogel | |
| US10385893B2 (en) | Electropermanent magnet activated microfluidic droplet size modulation | |
| Augustine et al. | Low-power electrically controlled thermoelastic microvalves integrated in thermoplastic microfluidic devices | |
| Aishan et al. | Bio-actuated microvalve in microfluidics using sensing and actuating function of Mimosa pudica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190125 |
|
| RJ01 | Rejection of invention patent application after publication |