CN109224135A - A kind of preparation method of antibacterial cement bracket - Google Patents
A kind of preparation method of antibacterial cement bracket Download PDFInfo
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- CN109224135A CN109224135A CN201811406064.6A CN201811406064A CN109224135A CN 109224135 A CN109224135 A CN 109224135A CN 201811406064 A CN201811406064 A CN 201811406064A CN 109224135 A CN109224135 A CN 109224135A
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- strontium
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- phosphate
- cement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The present invention provides a kind of preparation method of antibacterial cement bracket, can be improved the dispersing uniformity of silver-colored strontium in cement bracket, method includes the following steps: S1. prints polymer mesh structure body with high molecular material using 3D printer；S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium codope bone cement；S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtain a kind of finely dispersed antibacterial cement bracket of silver-colored strontium.
Description
Technical field
The invention belongs to bone injuries to repair field of medical materials, and in particular to a kind of antibacterial cement bracket.
Background technique
Artificial Bone Defect Repari is the ideal method of current treatment bone defect.Calcium sulfate is as a kind of traditional Bone Defect Repari material
Material, is had a good application prospect in terms of Bone Defect Repari with its good biocompatibility, osteoconductive etc..Artificial Bone Defect Repari material
The complication such as infection easily occur after material implantation, it is clinically usually used at present to be loaded with the bone cement of antibiotic as Bone Defect Repari material
Material, but the use of antibiotic is also easy to produce resistance, and excessively high generate to periarticular tissue of local concentration is endangered, and therefore, is sought
A kind of antibacterial bone cement that antibacterial effect is excellent has become one of the key content of Bone Defect Repari research.Silver is as a kind of most common
Antibacterial agent has been widely studied, and some researches show that silver ion can penetrate the cell wall of bacterium, and can lead to DNA of bacteria
Structural degeneration hinders bacterium DNA replication, so as to cause bacterial death.A kind of microelement of the strontium (Sr) as human body, not only may be used
To increase expression and the mescenchymal stem cell alkaline phosphatase activities of osteoblast related gene, and osteoclast can be hindered
Differentiation, be conducive to cell Proliferation, reach better skeletonization effect.But by silver-colored strontium codope and in bone cement in bone cement
The dispersion problem of silver-colored strontium requires study during self-curing.
Summary of the invention
The present invention provides a kind of preparation method of antibacterial cement bracket, can be improved point of silver-colored strontium in cement bracket
Uniformity is dissipated, method includes the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium and is co-doped with
Miscellaneous bone cement；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtained
To a kind of finely dispersed antibacterial cement bracket of silver.
Preferably, the high molecular material of S1 is selected polycaprolactone, polycarbonate, polyurethane, polyhydroxyalkanoate and is gathered
One of lactic acid or a variety of blends.
Preferably, silver powder additional amount is 2-10wt% in S2, and strontium powder addition is 2-10wt%, and silver-colored strontium mass ratio is excellent
It is selected as 2:1, the more other mass ratioes of the bone cement anti-microbial property of codope are stablized under the mass ratio, although more strontium can be improved
Bone active, but will affect the antibacterial effect of silver.
Preferably, the bone cement of S2 is tetracalcium phosphate+dicalcium phosphate dihydrate, unformed calcium phosphate+dicalcium phosphate dihydrate, phosphorus
Sour four calcium+type alpha tricalcium phosphate+calcium monohydrogen phosphate, partially crystallized calcium phosphate+calcium monohydrogen phosphate+hydroxyapatite, calcium monohydrogen phosphate+alpha-phosphate
Any one in tricalcium+calcium carbonate and tetracalcium phosphate-calcium monohydrogen phosphate system bone cement.
Preferably, the minimizing technology of S3 can remove or use heat form with organic solvent.The preferential side using heating
Method, during heating in addition to macromolecule can be removed, additionally it is possible to further increase the intensity of cement bracket.
The beneficial effects of the present invention are: the present invention enables nano silver and nanometer strontium to bear using polymer mesh structure body
It is loaded in polymer mesh structure body, to improve nano silver and strontium in the dispersing uniformity of cement bracket, silver-colored strontium is properly matched
The codope of ratio also further increases the anti-microbial property and skeletonization effect of bone cement, and preparation method is simple and fast and effective.
Specific embodiment
Embodiment 1
A kind of preparation method of antibacterial cement bracket can be improved the dispersing uniformity of silver-colored strontium in cement bracket,
Method includes the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium and is co-doped with
Miscellaneous bone cement, silver powder additional amount are 2wt%, and strontium powder addition is 1wt%；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtained
To a kind of finely dispersed antibacterial cement bracket of silver-colored strontium.
Embodiment 2
A kind of preparation method of antibacterial cement bracket can be improved the dispersing uniformity of silver-colored strontium in cement bracket,
Method includes the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium and is co-doped with
Miscellaneous bone cement, silver powder additional amount are 10wt%, and strontium powder addition is 5wt%；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtained
To a kind of finely dispersed antibacterial cement bracket of silver-colored strontium.
Embodiment 3
A kind of preparation method of antibacterial cement bracket can be improved the dispersing uniformity of silver-colored strontium in cement bracket,
Method includes the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium and is co-doped with
Miscellaneous bone cement, silver powder additional amount are 6wt%, and strontium powder addition is 3wt%；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtained
To a kind of finely dispersed antibacterial cement bracket of silver-colored strontium.
Embodiment 4
A kind of preparation method of antibacterial cement bracket can be improved the dispersing uniformity of silver-colored strontium in cement bracket,
Method includes the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium and is co-doped with
Miscellaneous bone cement, silver powder additional amount are 2wt%, and strontium powder addition is 2wt%；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtained
To a kind of finely dispersed antibacterial cement bracket of silver-colored strontium.
Silver-colored strontium mass ratio is 1:1 in embodiment 4, and silver-colored strontium mass ratio is 2:1 in embodiment 1, although strontium powder in embodiment 4
Additional amount is more than in embodiment 1, but test show its final anti-microbial property there is no embodiments 1 it is good.
Claims (5)
1. a kind of preparation method of antibacterial cement bracket, which comprises the following steps:
S1. polymer mesh structure body is printed with high molecular material using 3D printer；
S2. nano silver powder and nanometer strontium powder are added in bone cement slurry, stirs to obtain silver-colored strontium codope bone
Cement；
S3. above-mentioned slurry is injected in the resulting polymer mesh structure body of S1, then removes polymer mesh structure body, obtain one
The finely dispersed antibacterial cement bracket of the silver-colored strontium of kind.
2. a kind of preparation method of antibacterial cement bracket according to claim 1, which is characterized in that the macromolecule material of S1
Material selects one of polycaprolactone, polycarbonate, polyurethane, polyhydroxyalkanoate and polylactic acid or a variety of blends.
3. a kind of preparation method of antibacterial cement bracket according to claim 1, which is characterized in that silver powder adds in S2
Entering amount is 2-10wt%, and strontium powder addition is 1-5wt%, and silver-colored strontium mass ratio is 2:1.
4. a kind of preparation method of antibacterial cement bracket according to claim 1, which is characterized in that the bone cement of S2 is
Tetracalcium phosphate+dicalcium phosphate dihydrate, unformed calcium phosphate+dicalcium phosphate dihydrate, tetracalcium phosphate+type alpha tricalcium phosphate+calcium monohydrogen phosphate,
Partially crystallized calcium phosphate+calcium monohydrogen phosphate+hydroxyapatite, calcium monohydrogen phosphate+type alpha tricalcium phosphate+calcium carbonate and tetracalcium phosphate-phosphoric acid
Any one in hydrogen calcium system bone cement.
5. a kind of preparation method of antibacterial cement bracket according to claim 1, which is characterized in that the minimizing technology of S3
Heat form can be removed or used with organic solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811406064.6A CN109224135A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibacterial cement bracket |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811406064.6A CN109224135A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibacterial cement bracket |
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| CN109224135A true CN109224135A (en) | 2019-01-18 |
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| CN201811406064.6A Pending CN109224135A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibacterial cement bracket |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080213333A1 (en) * | 2004-10-25 | 2008-09-04 | Agnes Vignery | Methods and compositions for fostering and preserving bone growth |
| CN102380126A (en) * | 2011-10-28 | 2012-03-21 | 中国医学科学院北京协和医院 | Novel nano silver bone cement |
| CN106620843A (en) * | 2016-11-22 | 2017-05-10 | 天津大学 | Composite bone cement with bioactivity and antibacterial activity as well as preparation method and application |
| CN108478879A (en) * | 2018-03-30 | 2018-09-04 | 华南理工大学 | A kind of porous calcium phosphate/natural polymer compound rest and the preparation method and application thereof |
-
2018
- 2018-11-23 CN CN201811406064.6A patent/CN109224135A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080213333A1 (en) * | 2004-10-25 | 2008-09-04 | Agnes Vignery | Methods and compositions for fostering and preserving bone growth |
| CN102380126A (en) * | 2011-10-28 | 2012-03-21 | 中国医学科学院北京协和医院 | Novel nano silver bone cement |
| CN106620843A (en) * | 2016-11-22 | 2017-05-10 | 天津大学 | Composite bone cement with bioactivity and antibacterial activity as well as preparation method and application |
| CN108478879A (en) * | 2018-03-30 | 2018-09-04 | 华南理工大学 | A kind of porous calcium phosphate/natural polymer compound rest and the preparation method and application thereof |
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Application publication date: 20190118 |
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