CN109224119B - Pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent - Google Patents
Pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent Download PDFInfo
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- CN109224119B CN109224119B CN201811279076.7A CN201811279076A CN109224119B CN 109224119 B CN109224119 B CN 109224119B CN 201811279076 A CN201811279076 A CN 201811279076A CN 109224119 B CN109224119 B CN 109224119B
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Abstract
The invention belongs to the technical field of antitumor drugs, and particularly relates to a pi-conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent. The pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent has the following technical characteristics: firstly, the medicine is nano-particles with the particle size of 100nm-300 nm; secondly, the medicine is prepared by amphiphilic pi conjugated compounds. At present, no medicine and related medicine and medical method for inhibiting tumor and starving tumor and preventing further diffusion of tumor by using pi conjugated nano self-assembled particle intratumoral embolism are reported at home and abroad, and the invention fills the market gap. According to clinical records, the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent provided by the invention can effectively improve the tumor cure rate, reduce the tumor medical cost and relieve the pain of patients.
Description
Technical Field
The invention belongs to the technical field of antitumor drugs, and particularly relates to a pi-conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent.
Background
The anti-tumor methods frequently used in clinic comprise chemotherapy, radiotherapy, immunotherapy, gene therapy and the like, and have the problems of low recovery rate, high cost, excessive pain borne by the body and mind of a patient and the like.
Disclosure of Invention
Aiming at the problems, the invention provides a pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent, so as to improve the tumor cure rate, reduce the tumor medical cost and relieve the pain of patients.
The technical scheme provided by the invention for solving the technical problem is as follows:
a pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent, which is characterized in that: the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent is a nano particle with the particle size of 100nm-300 nm; and the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent is prepared from an amphiphilic pi conjugated compound.
Furthermore, in the pi-conjugated nano self-assembled particle intratumoral injection embolization tumor vascular anticancer agent provided by the invention, an amphiphilic pi-conjugated compound can be agglomerated in a tumor microenvironment through self-assembly. Preferably, the amphiphilic pi-conjugated compound may agglomerate by self-assembly within the tumor microenvironment at pH 6.5.
Furthermore, the pi conjugated nano self-assembly particle intratumoral injection embolization tumor blood vessel anticancer agent provided by the invention can be self-assembled and agglomerated into emboli with the diameter reaching the micrometer level or even the centimeter level in a tumor microenvironment under the action of low-frequency focused ultrasound. Preferably, the frequency of the low frequency focused ultrasound is 1 MHz. Preferably, the particle size of the formed emboli is greater than 2000 nm.
Further, in the pi-conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent provided by the invention, the amphiphilic pi-conjugated compound is a large pi-conjugated system compound, such as: hypericin, curcumin, and the like.
Furthermore, the particle size of the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent provided by the invention is about 250 nanometers.
Compared with the prior art, the invention has the beneficial technical effects that:
1. at present, the anti-tumor drugs and related medical methods for inhibiting tumors and preventing tumors from being further diffused by utilizing the pi conjugated nano self-assembled particle intratumoral embolism are not reported at home and abroad, and the invention fills the technical blank.
2. The pi conjugated nano self-assembled particle provided by the invention is used for intratumoral injection of an embolization tumor blood vessel anticancer agent, so that the tumor cure rate can be effectively improved, the tumor medical cost can be reduced, and the pain of a patient can be relieved.
In order to make the technical scheme and technical effect of the invention clearer and clearer, the following detailed description is provided for the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent disclosed by the invention with a specific implementation mode.
Detailed Description
The pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent provided by the invention has the following technical characteristics:
the medicine is nano-particles with the particle size of 100nm-300 nm;
② the medicine is made from amphiphilic pi conjugated compound.
Detailed description of the invention
Alternatively, depending on the difference in the degree of tolerance of the patient to different chemotherapeutic drugs, other pi-conjugated compounds may be used for adjunctive therapy, for example: curcumin (curcumin).
Detailed description of the invention
Detailed description of the invention
From the above, the various pi conjugated nano self-assembled particles provided by the invention are directly injected into the tumor to inject the embolism tumor blood vessel anticancer agent, so that local embolism of tumor blood vessels can be caused in the tumor through the self-assembly of the nano particles, the transmission of oxygen and nutrients to tumor tissues through blood is prevented, and further, on the basis of embolism, tumor cells are starved to prevent the diffusion and the metastasis of the tumor. Compared with the prior art, the novel medicine and the medical method provided by the invention can reduce the medical cost and relieve the pain of patients on the premise of effectively improving the tumor cure rate, and have obvious technical progress.
It should be noted that the scope of the present invention includes but is not limited to the above embodiments, and those skilled in the art can develop other embodiments based on the above embodiments, and any simple modification or equivalent replacement without departing from the innovative concept of the present invention is covered by the present invention and belongs to the scope of the present invention.
Claims (6)
1. A pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent, which is characterized in that:
the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent is a nano particle with the particle size of 100nm-300 nm; the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent is prepared from an amphiphilic pi conjugated compound;
the amphiphilic pi-conjugated compound is hypericin or curcumin or a mixture of hypericin and curcumin.
2. The pi-conjugated nano self-assembled particle intratumoral injection embolization tumor vascular anticancer agent according to claim 1, characterized in that: the amphiphilic pi-conjugated compounds can aggregate by self-assembly within the tumor microenvironment.
3. The pi-conjugated nano self-assembled particle intratumoral injection embolization tumor vascular anticancer agent according to claim 2, characterized in that: the amphiphilic pi-conjugated compounds can aggregate by self-assembly within the tumor microenvironment at pH 6.5.
4. The pi-conjugated nano self-assembled particle intratumoral injection embolization tumor vascular anticancer agent according to claim 1, characterized in that: the pi conjugated nano self-assembly particle intratumoral injection embolization tumor blood vessel anticancer agent can be self-assembled and agglomerated into embolization materials with the diameter reaching the micron level or the centimeter level in a tumor microenvironment under the action of low-frequency focused ultrasound.
5. The pi-conjugated nano self-assembled particle intratumoral injection embolization tumor vascular anticancer agent according to claim 4, characterized in that: the particle size of the embolus is larger than 2000 nm.
6. The pi-conjugated nano self-assembled particle intratumoral injected embolic tumor vascular anticancer agent according to any one of claims 1 to 5, characterized in that: the particle size of the pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent is 250 nm.
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| CN201811279076.7A CN109224119B (en) | 2018-10-30 | 2018-10-30 | Pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent |
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| CN201811279076.7A CN109224119B (en) | 2018-10-30 | 2018-10-30 | Pi conjugated nano self-assembled particle intratumoral injection embolization tumor blood vessel anticancer agent |
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| CN109224119B true CN109224119B (en) | 2021-02-23 |
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