CN109223048A - A method of prediction dog gestational age - Google Patents

A method of prediction dog gestational age Download PDF

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Publication number
CN109223048A
CN109223048A CN201811285918.XA CN201811285918A CN109223048A CN 109223048 A CN109223048 A CN 109223048A CN 201811285918 A CN201811285918 A CN 201811285918A CN 109223048 A CN109223048 A CN 109223048A
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China
Prior art keywords
gestational age
internal diameter
fetus
heart
dog
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CN201811285918.XA
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Chinese (zh)
Inventor
邓立新
胡赛娜
黄静
魏通
郝亚歌
王超
陈伟
王文静
贺丛
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Henan Agricultural University
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Henan Agricultural University
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Priority to CN201811285918.XA priority Critical patent/CN109223048A/en
Publication of CN109223048A publication Critical patent/CN109223048A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0866—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0883—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

The invention discloses a kind of methods for predicting dog gestational age, scanning are carried out to fetus using Ultrasound Instrument for animals, first from head down to backbone, the obvious place of heart fluctuation, which is found, along backbone carries out right-angled intersection scanning, standard Four-chamber view is obtained, finds root of ascending aorta on this section, to its internal diameter X1It measures；Downwards, posterior vena cava blood vessel passes through liver and enters atrium dextrum probe, to its internal diameter X at 2cm under right heart entrance2It measures；Probe observes downwards Fetus Abdominal, the longitudal section of Fetal Abdominal Aorta is found, to its internal diameter X3It measures；Then according to trend function Y1=0.0109 X1-0.3393；Y2=0.0112 X2-0.3467；Y3=0.0094 X3-0.2364；Three gestational age data are obtained after calculating, if Y1、Y2、Y3Without significant difference, it was demonstrated that the development of this heart of fetus is normal, and gestational age prediction is accurate.The present invention changes with gestational age in the linear relationship of high-positive correlation according to the internal diameter of three blood vessels come Accurate Prediction dog gestational age, and method is simple, and accuracy is high.

Description

A method of prediction dog gestational age
Technical field
Research the present invention relates to veterinary clinic to foetal animal, more particularly, to a kind of method for predicting dog gestational age.
Background technique
With the development of science and technology the development of ultrasonic diagnosis becomes better and approaching perfection day by day, ultrasound diagnosis is used especially on veterinary clinic Instrument it is universal, to the growth and development situation of the monitoring important big blood vessel of embryonic stage fetus, early screening go out certain congenital heart diseases and Disease etc. due to caused by dyshaemia has shown important role.Many is according to the report, quite big by one on people doctor Part congenital heart disease is often accompanied by the situation of aorta ascendens internal diameter exception, is also easier to obtain fetus liter master antenatal The two dimensional image of artery.The blood circulation situation of embryonic stage fetus is especially complex, mainly comprising coming from parent in posterior vena cava Blood containing abundant nutrition and hind leg reflux venous blood, people cures research shows that the change of posterior vena cava internal diameter is from one A side can reflect the change of right side atrium haemodynamics, therefore the function of the right heart is also reflected out.Therefore observation rises master The rule of Diameter variation also has important clinical meaning to dog fetal cardiac malformation to evaluate this variation.And measure tire The numerical indication of youngster's primary macrovascular internal diameter also has certain researching value to prediction dog gestational age.
Summary of the invention
The purpose of the present invention is to provide a kind of method for predicting dog gestational age, this method passes through the main big of measurement dog fetus Vessel diameter variation, not only can Accurate Prediction dog gestational age, but also certain congenital heart diseases of dog fetus are gone out to early screening or due to following Disease caused by ring obstacle also plays a significant role.
To achieve the above object, the present invention can take following technical proposals:
The method of prediction dog gestational age of the present invention are as follows:
Pregnant dog takes dorsal position, and using diasonograph for animals, probe finds cornua uteri first, respectively along two sides cornua uteri by tail Side to head side successively each fetus of scanning；
Each fetus is required to find head first, finds backbone downwards, and it is bright to find heart fluctuation downwards along the direction of backbone Aobvious position carries out right-angled intersection scanning, carries out the sector scan acquisition four chamber heart of standard after finding the thoracic cavity cross section containing heart Root of ascending aorta is found on this section in section, to its internal diameter X1It measures；Probe continues downward, it is seen that posterior vena cava Blood vessel passes through liver and enters atrium dextrum, to its internal diameter X at 2cm under right heart entrance2It measures；Probe continues observation tire downwards Youngster's abdomen finds the longitudal section of Fetal Abdominal Aorta, to its internal diameter X3It measures；
The root of ascending aorta internal diameter X that measurement is obtained1, posterior vena cava vessel diameter size X2With abdominal aorta X3Internal diameter Size is brought into respectively in following trend function:
Y1 = 0.0109 X1- 0.3393；
Y2 = 0.0112 X2- 0.3467；
Y3 = 0.0094 X3- 0.2364；
By calculating, each vessel diameter can correspond to a gestational age data, compare the diversity factor of three, if Y1、Y2、Y3Without significant Difference, it was demonstrated that the development of this heart of fetus is normal, and gestational age prediction is accurate.
As calculated Y1、Y2、Y3It differs larger, i.e., when dog fetus gestational age error is greater than 7 days, then can suspect the dog fetus Cardiovascular injuries (one or more) there are dysplasia, can to the certain congenital heart diseases of early screening or due to dyshaemia and Caused disease provides clinical foundation.
The present invention has the advantages that since (aorta ascendens, posterior vena cava blood vessel and abdomen are actively for three measured blood vessels Arteries and veins) internal diameter can passage at any time and thickening broadens, and be in the linear positive correlation of height with gestational age, so measuring in it Diameter size can Accurate Prediction dog gestational age；Meanwhile the growth and development situation of the important big blood vessel of embryonic stage fetus is monitored, once this is closed System changes, and can finding dog fetus as early as possible, there may be cardiovascular injuries dysplasia, goes out certain congenital heart diseases for early screening And the disease due to caused by dyshaemia provides foundation.
Detailed description of the invention
Fig. 1 is the posterior vena cava blood vessel B ultrasound figure of dog fetus.
Fig. 2 is the abdominal aorta blood vessel B ultrasound figure of dog fetus.
Fig. 3 is the aorta ascendens blood vessel B ultrasound figure of dog fetus.
Specific embodiment
More detailed explanation is done to the present invention below by specific embodiment, to facilitate the reason of those skilled in the art Solution.
Its concrete operation step of the method for prediction dog gestational age of the present invention are as follows:
So that pregnant dog is in dorsal position (and carrying out safe and reliable fixation) first, uses SIUI diasonograph Apogee for animals 1200V, linear array probe L8L38C, probe find cornua uteri first, are successively swept respectively along two sides cornua uteri by caudal to head side Each fetus is looked into, after determining fetus quantity, fetus is measured one by one by the following method；
Probe finds the head of fetus first, finds backbone downwards, and it is apparent to find heart fluctuation downwards along the direction of backbone Position carries out right-angled intersection scanning, carries out sector scan acquisition standard Four-chamber view after finding the thoracic cavity cross section containing heart, Root of ascending aorta (as described in Figure 3) is found on this section, and is measured, and to guarantee that data are accurate, can continuously be surveyed three times Obtain average value X1；Continue observation fetal thorax downwards, it can be seen that a very wide blood vessel passes through liver and enters atrium dextrum, this is For posterior vena cava (as shown in Figure 1), X is measured to its internal diameter at 2cm under right heart entrance2；Abdominal aorta is due to through whole A abdominal cavity, and and spine parallel, therefore probe is continued into observation Fetus Abdominal downwards, so that it may it is easily found fetus abdomen actively The longitudal section (as shown in Figure 2) of arteries and veins, and the internal diameter of abdominal aorta is measured, continuous survey obtains average value X three times3。
The internal diameter of three blood vessels all over time and thickening broadens, and with gestational age be in height linear positive It closes, the trend function of aorta ascendens are as follows: Y1 = 0.0109 X1- 0.3393；The trend function of abdominal aorta are as follows: Y3 = 0.0094 X3- 0.2364；The trend function of posterior vena cava are as follows: Y2 = 0.0112 X2 - 0.3467。
The root of ascending aorta internal diameter X that measurement is obtained1, posterior vena cava vessel diameter size X2With abdominal aorta X3 Internal diameter is brought into respectively in above-mentioned trend function, and by calculating, each vessel diameter can correspond to a gestational age data；Compare three The diversity factor of person, if Y1、Y2、Y3Without significant difference, it was demonstrated that the development of this heart of fetus is normal, and gestational age prediction is accurate.
When calculated dog fetus gestational age difference is larger (error be greater than 7 days when), it can suspect that the heart of the dog fetus is big There are dysplasia for blood vessel (one or more), mention to the certain congenital heart diseases of early screening or the disease due to caused by dyshaemia For clinical foundation.
It in clinical practice, can be in conjunction with the Developmental maturity of Foetal organ when assessing gestational age using the method for the present invention Get up to be assessed, to improve the accuracy of prediction.

Claims (1)

1. a kind of method for predicting dog gestational age, it is characterised in that:
Pregnant dog takes dorsal position, and using diasonograph for animals, probe finds cornua uteri first, respectively along two sides cornua uteri by tail Side to head side successively each fetus of scanning；
Each fetus is required to find head first, finds backbone downwards, and it is bright to find heart fluctuation downwards along the direction of backbone Aobvious position carries out right-angled intersection scanning, carries out the sector scan acquisition four chamber heart of standard after finding the thoracic cavity cross section containing heart Root of ascending aorta is found on this section in section, to its internal diameter X1It measures；Probe continues downward, it is seen that posterior vena cava Blood vessel passes through liver and enters atrium dextrum, to its internal diameter X at 2cm under right heart entrance2It measures；Probe continues observation tire downwards Youngster's abdomen finds the longitudal section of Fetal Abdominal Aorta, to its internal diameter X3It measures；
The root of ascending aorta internal diameter X that measurement is obtained1, posterior vena cava vessel diameter size X2With abdominal aorta X3Internal diameter Size is brought into respectively in following trend function:
Y1 = 0.0109 X1- 0.3393；
Y2 = 0.0112 X2- 0.3467；
Y3 = 0.0094 X3- 0.2364；
By calculating, each vessel diameter can correspond to a gestational age data, compare the diversity factor of three, if Y1、Y2、Y3Without significant Difference, it was demonstrated that the development of this heart of fetus is normal, and gestational age prediction is accurate.
CN201811285918.XA 2018-10-31 2018-10-31 A method of prediction dog gestational age Withdrawn CN109223048A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105708498A (en) * 2016-01-21 2016-06-29 黄华 Intelligent fetal heart sound monitoring instrument and monitoring method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105708498A (en) * 2016-01-21 2016-06-29 黄华 Intelligent fetal heart sound monitoring instrument and monitoring method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
魏通: "比格犬超声妊娠诊断及胎龄评估新枝术的研究", 《中国优秀硕士学位论文全文数据库》 *

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CN109223048A (en) A method of prediction dog gestational age

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Application publication date: 20190118