CN109222971B - Mammary gland imaging method and system - Google Patents

Mammary gland imaging method and system Download PDF

Info

Publication number
CN109222971B
CN109222971B CN201810988800.7A CN201810988800A CN109222971B CN 109222971 B CN109222971 B CN 109222971B CN 201810988800 A CN201810988800 A CN 201810988800A CN 109222971 B CN109222971 B CN 109222971B
Authority
CN
China
Prior art keywords
time
magnetic field
magnetic
reversal signal
reversal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201810988800.7A
Other languages
Chinese (zh)
Other versions
CN109222971A (en
Inventor
杨帆
陈易北
张晓峰
孙林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHENZHEN ET MEDICAL TECHNOLOGY CO LTD
Original Assignee
SHENZHEN ET MEDICAL TECHNOLOGY CO LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHENZHEN ET MEDICAL TECHNOLOGY CO LTD filed Critical SHENZHEN ET MEDICAL TECHNOLOGY CO LTD
Priority to CN201810988800.7A priority Critical patent/CN109222971B/en
Publication of CN109222971A publication Critical patent/CN109222971A/en
Application granted granted Critical
Publication of CN109222971B publication Critical patent/CN109222971B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention discloses a mammary gland imaging method and a system, which take magnetic nanoparticles as a mammary gland contrast agent, and add an adjustable transient magnetic field to stimulate the magnetic nanoparticles in mammary glands; acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal; then, when the adjustable transient magnetic field is not added, a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland is obtained and used as a second time reversal signal; finally, time reversal imaging is carried out according to the difference value of the first time reversal signal and the second time reversal signal so as to obtain a mammary gland image; the image with the mammary tissue magnetic susceptibility as the parameter is obtained, the technical problem that the contrast between the tumor and the healthy tissue is low in the existing mammary imaging method is solved, and the contrast between the tumor and the healthy tissue in the mammary image is improved.

Description

Mammary gland imaging method and system
Technical Field
The invention relates to the field of images, in particular to a method and a system for breast imaging.
Background
Breast cancer is the disease with the highest incidence among the cancers suffered by women at present. Early detection of breast cancer is a critical step, and if it can be removed before the size of the malignant tumor reaches 1.5 cm, the survival rate of the patient is as high as 90%. In order to make up for the deficiencies of conventional molybdenum target imaging and magnetic resonance MRI imaging, a variety of new medical imaging techniques have emerged in recent years, with microwave imaging techniques developing rapidly. Microwaves comprise electromagnetic waves having a frequency from several hundred megahertz to several gigahertz, and the interaction of electromagnetic waves with biological tissues in this frequency band depends on the dielectric constant of a substance. Numerous experiments have shown that tumors can be well distinguished from healthy tissue by virtue of this difference in permittivity. However, when the difference in dielectric constant between tumor and normal tissue is as small as about 10%, especially for dense breast formation, microwave imaging faces the challenge of reduced specificity, with low tumor contrast to other healthy tissues.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, an object of the present invention is to provide a breast imaging method and system, which can improve the contrast between the tumor and the healthy tissue in the breast image.
The technical scheme adopted by the invention is as follows: a method of breast imaging comprising the steps of:
a magnetic field adding step: magnetic nanoparticles are used as a contrast agent of the mammary gland, and an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in the mammary gland;
a first time reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal;
a second time-reversal signal acquisition step: acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time-reversal signal when the adjustable transient magnetic field is not added;
time reversal imaging step: and performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image.
Further, the breast imaging method further includes:
repeating the steps: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time-reversal signal obtaining step, and the time-reversal imaging step to improve the resolution of the breast image.
Further, the first time-reversal signal acquisition step includes:
acquiring a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
acquiring a time function of the magnetic susceptibility of the magnetic nanoparticles according to a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
and acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time-reversal signal according to the time function of the magnetic susceptibility of the magnetic nanoparticles.
Further, a time function of the magnetic susceptibility of the magnetic nanoparticles is obtained by utilizing a DBIM method according to a time domain expression of the instantaneous magnetic field strength of the adjustable transient magnetic field.
Further, the method for generating the adjustable transient magnetic field comprises the following steps:
an RLC charge and discharge circuit is utilized to generate an instantaneous current that passes through the winding coil and releases the transient magnetic field in an underdamped form.
Further, the method of varying the adjustable transient magnetic field comprises:
changing the geometry of the winding coil and/or the inductance of the winding coil and/or the capacitance in the RLC charge and discharge circuits and/or the resistance in the RLC charge and discharge circuits to reduce the pulse width of the transient magnetic field.
Further, the method of varying the adjustable transient magnetic field further comprises:
changing the phase shift of the transient current to increase the oscillation frequency of the transient magnetic field.
The other technical scheme adopted by the invention is as follows: a breast imaging system comprising:
a magnetic field adding module for performing the magnetic field adding step: magnetic nanoparticles are used as a contrast agent of the mammary gland, and an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in the mammary gland;
a first time-reversal signal acquisition module for performing a first time-reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal;
a second time-reversal signal acquisition module for performing a second time-reversal signal acquisition step: acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time-reversal signal when the adjustable transient magnetic field is not added;
a time-reversal imaging module for performing the time-reversal imaging step: and performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image.
Further, the breast imaging system further comprises:
a repetition module for performing the repetition step: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time-reversal signal obtaining step, and the time-reversal imaging step to improve the resolution of the breast image.
Further, the magnetic field adding module comprises an RLC charging and discharging circuit and a winding coil, and the output end of the RLC charging and discharging circuit is connected with the input end of the winding coil.
The invention has the beneficial effects that:
the invention relates to a mammary gland imaging method and a system, which take magnetic nanoparticles as a mammary gland contrast agent, and add an adjustable transient magnetic field to stimulate the magnetic nanoparticles in mammary glands; acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal; then, when the adjustable transient magnetic field is not added, a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland is obtained and used as a second time reversal signal; finally, time reversal imaging is carried out according to the difference value of the first time reversal signal and the second time reversal signal so as to obtain a mammary gland image; the image with the mammary tissue magnetic susceptibility as the parameter is obtained, the technical problem that the contrast between the tumor and the healthy tissue is low in the existing mammary imaging method is solved, and the contrast between the tumor and the healthy tissue in the mammary image is improved.
Drawings
The following further describes embodiments of the present invention with reference to the accompanying drawings:
FIG. 1 is a schematic diagram of a prior art magnetic nanoparticle-based microwave imaging;
FIG. 2 is a schematic view of an embodiment of the adjustable transient magnetic field and the breast in a breast imaging method of the present invention;
FIG. 3 is a method flow diagram of one embodiment of a breast imaging method of the present invention;
FIG. 4 is a waveform illustrating a transient magnetic field in a breast imaging method according to an embodiment of the present invention;
wherein, 1-thoracic cavity; 2-mammary gland; 3-a microwave antenna; 4-external magnetic field S pole; 5-external magnetic field N pole; 6-winding coil.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
A method of breast imaging comprising the steps of:
a magnetic field adding step: magnetic nanoparticles are used as a contrast agent of the mammary gland, and an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in the mammary gland;
a first time reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal;
a second time-reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time reversal signal when the adjustable transient magnetic field is not added;
time reversal imaging step: and performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image.
The image with the mammary tissue magnetic susceptibility as the parameter is obtained by the method, the technical problem that the contrast between the tumor and the healthy tissue is low in the existing mammary imaging method is solved, and the contrast between the tumor and the healthy tissue in the mammary image is improved.
As a further improvement of the technical solution, the first time-reversal signal acquisition step specifically includes:
acquiring a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
acquiring a time function of the magnetic susceptibility of the magnetic nanoparticles by using a DBIM method according to a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
and acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time-reversal signal according to the time function of the magnetic susceptibility of the magnetic nanoparticles.
In addition, the magnetic nano-particles are adoptedMagnetic Nanoparticles (MNPs) have the property of binding to tumor receptors with the aid of antibodies in breast imaging protocols with contrast agents for breast detection, by means of which nanoparticles are injected intravenously into the human body. The nanoparticles entering the human body are diffused and lost, and only a small part of the nanoparticles are combined with tumor cells (<1%). As shown in fig. 1, fig. 1 is a schematic diagram of a conventional microwave imaging based on magnetic nanoparticles; the breast is surrounded by an array of microwave antennas for transmitting and receiving microwave signals. Each antenna can be used as a transmitting end to transmit microwave pulse signals, and the other antennas are used as receiving ends to receive echo signals reflected by breast tissues. Two external magnetic fields of south (S) and north (N) are arranged at two ends of the breast. The general mechanism of enhancing microwave imaging based on magnetic nanoparticles is to change the magnetic susceptibility C [ mu ] of the magnetic nanoparticles by utilizing the difference of opening and closing of an external magnetic field H, so that the contrast of the magnetic susceptibility of tumors and other healthy tissues is as high as 10: 1. In the present imaging principle, the position and strength of the applied static magnetic field are only simply specified. Thus, the imaging effect is affected by the interference of the imaging system caused by the intensity of the received signal, the coupling size between the antennas and the position offset, and the effective scattering field, namely the echo signal reflected by the tumor tissue combined with the nano particles, is usually very weak (10 smaller than the received signal)3Orders of magnitude), the resolution of the breast image is low. Therefore, as a further improvement of the technical solution, the breast imaging method further comprises:
repeating the steps: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time reversal signal obtaining step and the time reversal imaging step so as to improve the resolution of the mammary gland image.
As a further improvement of the technical scheme, the generation method of the adjustable transient magnetic field comprises the following steps: an RLC charge-discharge circuit is utilized to generate instantaneous current, and the instantaneous current passes through a winding coil and releases a transient magnetic field in an underdamping mode. Further, the method of varying the adjustable transient magnetic field comprises:
changing the geometry of the winding coil and/or the inductance L of the winding coil and/or the charging and discharging of the capacitance C and/or RLC in the charging and discharging circuitA resistor R in the circuit to reduce the pulse width of the transient magnetic field. Further, the phase shift of the instantaneous current can also be changed
Figure BDA0001780308870000041
To increase the oscillation frequency of the transient magnetic field. By selecting the appropriate geometry of the winding coil and selecting the appropriate R, L, C,
Figure BDA0001780308870000042
The parameter combination can not only improve the resolution of the mammary gland image taking the magnetic susceptibility as the parameter, but also reduce the interference caused by other glands.
The following describes the specific procedure of the breast imaging method:
firstly, explaining a prior art imaging method based on external static magnetic field microwave imaging of magnetic nanoparticles, which uses magnetic nanoparticles as a contrast agent, referring to fig. 1, a breast 2 on a chest cavity 1 is surrounded by a microwave antenna array, the microwave antenna array is used for transmitting and receiving microwave signals, and the microwave antenna array comprises a plurality of microwave antennas 3; each microwave antenna can be used as a transmitting end to transmit microwave pulse signals, and other antennas are used as receiving ends to receive echo signals reflected by mammary tissues. Two external magnetic fields of south (an external magnetic field S pole 4) and north (an external magnetic field N pole 5) are arranged at two ends of the mammary gland. For the excitation of the mth transmitting antenna, the electric field strength at the nth receiving end is expressed as:
Esca(rn|rm)＝E(rn|rm)-Eb(rn|rm) (1)
wherein E issca，E，EbRespectively scattered field, total field and electric field generated by background. For the magnetic nanoparticle fringe field are:
Figure BDA0001780308870000051
wherein
Figure BDA0001780308870000052
Is a green function, V is a calculation region, magnetic current Mn(r) is expressed as:
Figure BDA0001780308870000053
wherein C isμMagnetic susceptibility of magnetic nanoparticles, JmIs the m-th excitation current. From the equations (2), (3), it can be seen that the scatter field E is calculatedscaThe magnetic susceptibility C can be determinedμ。
To solve for magnetic susceptibility CμThe classical Discrete Borne Iterative Method (DBIM) method can be employed. A set of equations for the scattered field is obtained by riemann summation and the non-linear solution is converted into a set of linear equations AX ═ b. Where the matrix A is an M K matrix, M is the number of antennas excited, K is the unknown quantity, and X is the magnetic susceptibility C between the tumor and the backgroundμB is the difference between the measured value and the simulated value, and the estimated value of the magnetic susceptibility can be obtained by an iterative method, thereby obtaining the magnetic susceptibility CμFunctional expression as a function of the applied magnetic field H:
Figure BDA0001780308870000054
wherein<·>The operator is a complex conjugate inner product of the two,
Figure BDA0001780308870000055
is magnetic susceptibility CμMagnetic field strength, μ, generated by the breast measured at point N, 00In order to be a magnetic permeability in a vacuum,
Figure BDA0001780308870000056
the electric field operator generated for the magnetic nanoparticles-i.e.,
Figure BDA0001780308870000057
calculating the magnetic susceptibility of the mammary tissue under the external static magnetic field by the formulas (1) to (5)Then subtracting the susceptibility of mammary gland tissue under the condition of no external magnetic field to obtain the change of susceptibility
Figure BDA0001780308870000058
Figure BDA0001780308870000059
The magnetic susceptibility in the absence of an applied magnetic field. At this time, the calculation is carried out for each point in space
Figure BDA00017803088700000510
An image can be obtained about the change in magnetic susceptibility.
In order to improve the contrast of tumor and healthy cells in the mammary gland image, the invention uses an adjustable transient magnetic field to replace an external static magnetic field in figure 1 so as to obtain the mammary gland image with magnetic susceptibility as a parameter. Referring to fig. 2, fig. 2 is a schematic view of an embodiment of the adjustable transient magnetic field and the breast in a breast imaging method of the present invention; an adjustable transient magnetic field is additionally added, an RLC charge-discharge circuit generates instant current, and the instant current passes through the winding coil 6 and releases the magnetic field in an underdamping mode. The transient magnetic field can be generated by a single winding coil or an 8-shaped coil and other coils. As shown in fig. 2, a single winding coil is used to generate transient magnetic fields from the ports of winding coil 6 instead of the applied north and south magnetic fields in fig. 1. Referring to fig. 3, fig. 3 is a flowchart of a breast imaging method according to an embodiment of the present invention; after turning on the adjustable transient magnetic field to be added to the mammary tissue, to obtain the time function of the magnetic susceptibility of the magnetic nanoparticles, first, the instantaneous current I is defined as a function of time:
Figure BDA0001780308870000061
wherein
Figure BDA0001780308870000062
L is inductance of the winding coil, C is capacitance in the RLC charge-discharge circuit, and R is resistance of the resistance in the RLC charge-discharge circuit.
At this time, the instantaneous magnetic field strength H generated from the winding coil port d can be expressed as:
Figure BDA0001780308870000063
wherein D1 and D2 are respectively the inner diameter and the outer diameter of the coil, l is the half length of the coil, D is the distance from the coil port, and the current density
Figure BDA0001780308870000064
Psi is the number of coil turns. And (3) substituting the formula (6) for the formula (7) to obtain the time domain waveform of the transient magnetic field H.
Then, a general form of current damping variation is defined, and an arbitrary phase shift is added to the time domain signal (6)
Figure BDA0001780308870000065
At this time, equation (6) becomes:
Figure BDA0001780308870000066
the substitution of equation (8) for equation (7) gives a general form of the time domain waveform of the transient magnetic field by varying the values of R, L, C,
Figure BDA0001780308870000067
the waveform change of the transient magnetic field can be controlled. Referring to FIG. 4, FIG. 4 is a waveform illustrating an embodiment of a transient magnetic field in a breast imaging method according to the present invention; fig. 4 shows a graph of transient magnetic field waveforms for 2 normalized magnetic field strengths, with the solid and dashed lines representing the transient magnetic field strength waveforms phase shifted by 0 and 90 degrees, respectively. It can be seen that the phase shift does not change the pulse width, but only increases the oscillation frequency.
Assuming that K major susceptibility change points exist and secondary scattering of the wave at these points is neglected, at the nth receiving end, the time-varying susceptibility function can be obtained from equations (4) - (8) by using the DBIM method
Figure BDA0001780308870000068
It is represented in the frequency domain as:
Figure BDA0001780308870000069
wherein
Figure BDA00017803088700000610
As a function of the magnetic susceptibility of the kth strong scattering point. k1 is the number of scattering points of the tumor, k2 is the number of strong scattering points generated by gland and other interference, and k is k1+ k 2. Taking complex conjugate of formula (9) to obtain time-reversed magnetic susceptibility
Figure BDA00017803088700000611
Time domain signals:
Figure BDA00017803088700000612
where Ω is a normalization factor, such that
Figure BDA00017803088700000613
Formula (10) is relative magnetic susceptibility
Figure BDA00017803088700000614
I.e. the first time-reversed signal.
Then the adjustable transient magnetic field is closed (namely the adjustable transient magnetic field is not added), and a time reversal signal of the magnetic susceptibility of the breast tissue background magnetic nanoparticles in the space is obtained
Figure BDA0001780308870000071
That is, the second time-reversal signal, and in particular, the magnetic susceptibility without the addition of the adjustable transient magnetic field can be obtained by equation (4)
Figure BDA0001780308870000072
Imaging the difference between the first time-reversed signal and the second time-reversed signal at each point in space at a position rnA strong scattering point concentration is obtainedFocal imaging:
Figure BDA0001780308870000073
where v is the imaging volume. The mammary gland image obtained by the formula (11) with the mammary gland tissue magnetic susceptibility as a parameter is a brand new mammary gland tissue imaging method, and the contrast of the mammary gland image can be improved.
After the mammary gland image with high contrast and taking the mammary gland tissue magnetic susceptibility as a parameter is obtained by the method, the mammary gland image with high resolution can be obtained by adjusting the adjustable transient magnetic field, and specifically:
(1) changing the geometric structure of the winding coil and R, L and C parameters to obtain transient magnetic fields with different pulse widths and different damping coefficients;
(2) the narrower the pulse width of the transient magnetic field is, the higher the imaging resolution is;
(3) by varying the ratio of R, L, C,
Figure BDA0001780308870000074
the waveforms with the same pulse width and different oscillation frequencies can be obtained, and the higher the oscillation frequency of the transient magnetic field is, the higher the imaging resolution is. But the clearer the gland brings about interference.
In summary, the three criteria (1) to (3) are used to select appropriate parameters, i.e., R, L, C,
Figure BDA0001780308870000075
it is possible to both secure the imaging resolution and suppress the interference. The concrete expression is as follows: under the condition of determining the geometric structure of the coil (such as a circular winding coil or an 8-shaped coil), the narrow pulse width is realized by the optimized combination of the values of R, L and C, and the adjustment is carried out simultaneously
Figure BDA0001780308870000076
Parameter, increase the oscillation frequency of the waveform. By reasonably selecting the geometric structure of the winding coil and coordinating R, L and C,
Figure BDA0001780308870000077
the high-resolution mammary gland image can be obtained by the parameter value taking.
The present invention also provides a breast imaging system comprising:
a magnetic field adding module for performing the magnetic field adding step: magnetic nanoparticles are used as a contrast agent of the mammary gland, and an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in the mammary gland; the magnetic field adding module comprises an RLC charging and discharging circuit and a winding coil, and the output end of the RLC charging and discharging circuit is connected with the input end of the winding coil. An RLC charge-discharge circuit is utilized to generate instantaneous current, and the instantaneous current passes through a winding coil and releases a transient magnetic field in an underdamping mode.
A first time-reversal signal acquisition module for performing a first time-reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal;
a second time-reversal signal acquisition module for performing a second time-reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time reversal signal when the adjustable transient magnetic field is not added;
a time-reversal imaging module for performing the time-reversal imaging step: and performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image.
By using the mammary gland imaging system, a mammary gland image with high contrast can be obtained.
As a further improvement of the technical solution, the breast imaging system further comprises:
a repetition module for performing the repetition step: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time reversal signal obtaining step and the time reversal imaging step so as to improve the resolution of the mammary gland image.
For a specific working process of each module in the breast imaging system, please refer to the description of the specific process of the breast imaging method, which is not repeated.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (5)

1. A method of breast imaging comprising the steps of:
a magnetic field adding step: magnetic nanoparticles are used as a contrast agent of mammary gland, an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in mammary gland, the adjustable transient magnetic field is generated by utilizing an RLC (radio link control) charging and discharging circuit to generate transient current, the transient current passes through a winding coil and releases a transient magnetic field in an underdamped form, and the method for changing the adjustable transient magnetic field comprises changing the geometric structure of the winding coil and/or the inductance of the winding coil and/or the capacitance in the RLC charging and discharging circuit and/or the resistance in the RLC charging and discharging circuit to reduce the pulse width of the transient magnetic field;
a first time reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal;
a second time-reversal signal acquisition step: acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time-reversal signal when the adjustable transient magnetic field is not added;
time reversal imaging step: performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image;
repeating the steps: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time-reversal signal obtaining step, and the time-reversal imaging step to improve the resolution of the breast image.
2. A method of breast imaging according to claim 1 wherein the first time-reversed signal acquisition step comprises:
acquiring a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
acquiring a time function of the magnetic susceptibility of the magnetic nanoparticles according to a time domain expression of the instantaneous magnetic field intensity of the adjustable transient magnetic field;
and acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time-reversal signal according to the time function of the magnetic susceptibility of the magnetic nanoparticles.
3. The breast imaging method according to claim 2, wherein the time function of the magnetic susceptibility of the magnetic nanoparticles is obtained by means of DBIM method according to the time domain expression of the instantaneous magnetic field strength of the adjustable transient magnetic field.
4. A breast imaging method according to either of claims 2 and 3 wherein the method of varying the adjustable transient magnetic field further comprises:
changing the phase shift of the transient current to increase the oscillation frequency of the transient magnetic field.
5. A breast imaging system, comprising:
a magnetic field adding module for performing the magnetic field adding step: magnetic nanoparticles are used as a contrast agent of the mammary gland, and an adjustable transient magnetic field is added to stimulate the magnetic nanoparticles in the mammary gland;
a first time-reversal signal acquisition module for performing a first time-reversal signal acquisition step: acquiring a time reversal signal of the magnetic susceptibility of the magnetic nanoparticles as a first time reversal signal, wherein the magnetic field adding module comprises an RLC (radio link control) charging and discharging circuit and a winding coil, and the output end of the RLC charging and discharging circuit is connected with the input end of the winding coil;
a second time-reversal signal acquisition module for performing a second time-reversal signal acquisition step: acquiring a time-reversal signal of the magnetic susceptibility of the magnetic nanoparticles in the mammary gland as a second time-reversal signal when the adjustable transient magnetic field is not added;
a time reversal imaging module for performing the time reversal imaging step: performing time-reversal imaging according to the difference value of the first time-reversal signal and the second time-reversal signal to obtain a mammary gland image;
a repetition module for performing the repetition step: changing the adjustable transient magnetic field and repeating the magnetic field adding step, the first time-reversal signal obtaining step, and the time-reversal imaging step to improve the resolution of the breast image.
CN201810988800.7A 2018-08-28 2018-08-28 Mammary gland imaging method and system Active CN109222971B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810988800.7A CN109222971B (en) 2018-08-28 2018-08-28 Mammary gland imaging method and system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810988800.7A CN109222971B (en) 2018-08-28 2018-08-28 Mammary gland imaging method and system

Publications (2)

Publication Number Publication Date
CN109222971A CN109222971A (en) 2019-01-18
CN109222971B true CN109222971B (en) 2022-05-17

Family

ID=65068797

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810988800.7A Active CN109222971B (en) 2018-08-28 2018-08-28 Mammary gland imaging method and system

Country Status (1)

Country Link
CN (1) CN109222971B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110680319B (en) * 2019-10-25 2020-08-14 深圳技术大学 Magnetic induction molecular imaging method and system for biological tissue detection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102333567A (en) * 2009-02-27 2012-01-25 皇家飞利浦电子股份有限公司 Therapeutic apparatus for treating a subject using magnetic nanoparticles
JP2014036901A (en) * 2009-02-05 2014-02-27 Toshiba Corp Magnetic resonance imaging apparatus
CN104101877A (en) * 2014-06-27 2014-10-15 深圳先进技术研究院 Lesion area imaging system and method
CN104617840A (en) * 2015-01-30 2015-05-13 天津工业大学 Switch sequential control and PLC oscillation producing magnetic field based energy-saving control circuit
CN104881858A (en) * 2014-02-27 2015-09-02 上海联影医疗科技有限公司 Method and device for extracting background parenchymal enhancement in breast

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100292564A1 (en) * 2009-05-18 2010-11-18 Cantillon Murphy Padraig J System and Method For Magnetic-Nanoparticle, Hyperthermia Cancer Therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014036901A (en) * 2009-02-05 2014-02-27 Toshiba Corp Magnetic resonance imaging apparatus
CN102333567A (en) * 2009-02-27 2012-01-25 皇家飞利浦电子股份有限公司 Therapeutic apparatus for treating a subject using magnetic nanoparticles
CN104881858A (en) * 2014-02-27 2015-09-02 上海联影医疗科技有限公司 Method and device for extracting background parenchymal enhancement in breast
CN104101877A (en) * 2014-06-27 2014-10-15 深圳先进技术研究院 Lesion area imaging system and method
CN104617840A (en) * 2015-01-30 2015-05-13 天津工业大学 Switch sequential control and PLC oscillation producing magnetic field based energy-saving control circuit

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gennaro Bellizzi,Ovidio M.Bucci and Ilaria Catapano.Microwave Cancer Imaging Exploiting Magnetic Nanoparticles as Contrast Agent.《IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING》.2011, *
Microwave Cancer Imaging Exploiting Magnetic Nanoparticles as Contrast Agent;Gennaro Bellizzi,Ovidio M.Bucci and Ilaria Catapano;《IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING》;20110930;第2528-2536页 *

Also Published As

Publication number Publication date
CN109222971A (en) 2019-01-18

Similar Documents

Publication Publication Date Title
Shlager et al. Accurate analysis of TEM horn antennas for pulse radiation
Klemm et al. Microwave radar-based differential breast cancer imaging: Imaging in homogeneous breast phantoms and low contrast scenarios
Nohava et al. Flexible multi-turn multi-gap coaxial RF coils: Design concept and implementation for magnetic resonance imaging at 3 and 7 Tesla
Frass-Kriegl et al. Multi-turn multi-gap transmission line resonators–Concept, design and first implementation at 4.7 T and 7 T
Puchnin et al. Metamaterial inspired wireless coil for clinical breast imaging
Klemm et al. Towards contrast enhanced breast imaging using ultra-wideband microwave radar system
Kim et al. Development of a 7 T RF coil system for breast imaging
Elabyad et al. A novel mono-surface antisymmetric 8Tx/16Rx coil array for parallel transmit cardiac MRI in pigs at 7T
CN109222971B (en) Mammary gland imaging method and system
Mikhailovskaya et al. A new quadrature annular resonator for 3 T MRI based on artificial-dielectrics
Vít et al. A broad tuneable birdcage coil for mouse 1H/19F MR applications
Al-Gburi et al. A miniature raspberry shaped UWB monopole antenna based on microwave imaging scanning technique for kidney stone early detection
Puchnin et al. Application of topological edge states in magnetic resonance imaging
Czerny et al. Flexible multi‐turn multi‐gap coaxial RF coils: enabling a large range of coil sizes
Hirata et al. Analysis of a flexible surface‐coil‐type resonator for magnetic resonance measurements
Amida et al. A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg
CN107064839A (en) A kind of magnetic resonance imaging radiofrequency coil that left/right hand microstrip line is combined based on point shape
Jandaliyeva et al. Volumetric wireless coils for breast MRI: A comparative analysis of metamaterial-inspired coil, Helmholtz coil, ceramic coil, and solenoid
Gokyar et al. Magnetic resonance imaging assisted by wireless passive implantable fiducial e-markers
Raut Quantitative Evaluation of High Impedance Microstrip Array for Ultrahigh Field MR Imaging
Chu Near-fields in attenuating media
Kordzadeh et al. Optimal-permittivity dielectric liners for a 4.7 T transceiver array
US11243280B2 (en) Augmented tune/match circuits for high performance dual nuclear transmission line resonators
US20240036127A1 (en) Quadrature RF Transmit Coil At A Vertical Main Field MRI System
Sonawane et al. Radiofrequency knee coil for MR application

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: Yang Fan

Inventor after: Chen Yibei

Inventor after: Zhang Xiaofeng

Inventor after: Sun Lin

Inventor before: Yang Fan

Inventor before: Zhang Xiaofeng

Inventor before: Sun Lin

GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder
CP02 Change in the address of a patent holder

Address after: No.1 Workshop A601, MeiXun digital technology factory, No.19 Jinxiu Middle Road, Laokeng community, Longtian street, Pingshan District, Shenzhen, Guangdong 518000

Patentee after: SHENZHEN ET MEDICAL TECHNOLOGY CO.,LTD.

Address before: 518000 11b01, 11b02, 11b03 and 11b04, building B, zone 1, West Shenzhen Bay science and technology ecological park, Baishi Road, Nansha street, Nansha West Road, Nanshan District, Shenzhen City, Guangdong Province

Patentee before: SHENZHEN ET MEDICAL TECHNOLOGY CO.,LTD.