CN109200446B - Medicine injection device for endoscope - Google Patents
Medicine injection device for endoscope Download PDFInfo
- Publication number
- CN109200446B CN109200446B CN201811075254.4A CN201811075254A CN109200446B CN 109200446 B CN109200446 B CN 109200446B CN 201811075254 A CN201811075254 A CN 201811075254A CN 109200446 B CN109200446 B CN 109200446B
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- molecular sieve
- silver
- extension tube
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- 239000003814 drug Substances 0.000 title claims abstract description 19
- 238000002347 injection Methods 0.000 title claims abstract description 16
- 239000007924 injection Substances 0.000 title claims abstract description 16
- 229940079593 drug Drugs 0.000 title claims description 9
- 239000002808 molecular sieve Substances 0.000 claims abstract description 85
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims abstract description 85
- 239000000203 mixture Substances 0.000 claims abstract description 57
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 47
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 35
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229910052709 silver Inorganic materials 0.000 claims abstract description 29
- 239000004332 silver Substances 0.000 claims abstract description 29
- 239000002861 polymer material Substances 0.000 claims abstract description 28
- 239000004793 Polystyrene Substances 0.000 claims abstract description 20
- 229920000120 polyethyl acrylate Polymers 0.000 claims abstract description 20
- 229920002223 polystyrene Polymers 0.000 claims abstract description 20
- 238000007789 sealing Methods 0.000 claims abstract description 18
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 17
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 claims abstract description 16
- RRQYJINTUHWNHW-UHFFFAOYSA-N 1-ethoxy-2-(2-ethoxyethoxy)ethane Chemical compound CCOCCOCCOCC RRQYJINTUHWNHW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 15
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 15
- 229940019778 diethylene glycol diethyl ether Drugs 0.000 claims abstract description 15
- -1 1H-1, 2, 4-triazolyl Chemical group 0.000 claims abstract description 10
- RGKUSPKMWIGVLG-UHFFFAOYSA-N n'-(2-aminoethyl)ethane-1,2-diamine;trimethoxy(propyl)silane Chemical compound NCCNCCN.CCC[Si](OC)(OC)OC RGKUSPKMWIGVLG-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940080340 sodium dihydroxycetyl phosphate Drugs 0.000 claims abstract description 8
- VDHLWCWZVFZQLZ-UHFFFAOYSA-M sodium;bis(2-hydroxyhexadecyl) phosphate Chemical compound [Na+].CCCCCCCCCCCCCCC(O)COP([O-])(=O)OCC(O)CCCCCCCCCCCCCC VDHLWCWZVFZQLZ-UHFFFAOYSA-M 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 60
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 57
- 239000003381 stabilizer Substances 0.000 claims description 38
- 238000003756 stirring Methods 0.000 claims description 38
- 239000002131 composite material Substances 0.000 claims description 35
- 239000000126 substance Substances 0.000 claims description 34
- 239000011259 mixed solution Substances 0.000 claims description 25
- 239000004014 plasticizer Substances 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 18
- 239000008213 purified water Substances 0.000 claims description 17
- 238000005406 washing Methods 0.000 claims description 17
- 238000001035 drying Methods 0.000 claims description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 claims description 14
- DHAHRLDIUIPTCJ-UHFFFAOYSA-K aluminium metaphosphate Chemical compound [Al+3].[O-]P(=O)=O.[O-]P(=O)=O.[O-]P(=O)=O DHAHRLDIUIPTCJ-UHFFFAOYSA-K 0.000 claims description 14
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 claims description 12
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 12
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 9
- UUODQIKUTGWMPT-UHFFFAOYSA-N 2-fluoro-5-(trifluoromethyl)pyridine Chemical compound FC1=CC=C(C(F)(F)F)C=N1 UUODQIKUTGWMPT-UHFFFAOYSA-N 0.000 claims description 8
- 238000001125 extrusion Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 8
- 239000004593 Epoxy Substances 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- BCOPZYOFLSLJPM-UHFFFAOYSA-N bis(6-methylheptyl) cyclohex-3-ene-1,2-dicarboxylate Chemical compound CC(C)CCCCCOC(=O)C1CCC=CC1C(=O)OCCCCCC(C)C BCOPZYOFLSLJPM-UHFFFAOYSA-N 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 7
- BOXSVZNGTQTENJ-UHFFFAOYSA-L zinc dibutyldithiocarbamate Chemical compound [Zn+2].CCCCN(C([S-])=S)CCCC.CCCCN(C([S-])=S)CCCC BOXSVZNGTQTENJ-UHFFFAOYSA-L 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 5
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 5
- IDEAEPXBQLUDAI-UHFFFAOYSA-N dibutylcarbamodithioic acid;zinc Chemical compound [Zn].CCCCN(C(S)=S)CCCC IDEAEPXBQLUDAI-UHFFFAOYSA-N 0.000 claims description 5
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 238000001839 endoscopy Methods 0.000 claims 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 25
- 239000003513 alkali Substances 0.000 abstract description 16
- 239000002253 acid Substances 0.000 abstract description 14
- 239000000463 material Substances 0.000 abstract description 9
- 239000002585 base Substances 0.000 abstract description 3
- 239000012046 mixed solvent Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 238000002357 laparoscopic surgery Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000012084 abdominal surgery Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001027 hydrothermal synthesis Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000000962 organic group Chemical group 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 108700024661 strong silver Proteins 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- YNXLGBUUMLLVGF-UHFFFAOYSA-N 3-(2-ethylhydrazinyl)propan-1-amine Chemical compound CCNNCCCN YNXLGBUUMLLVGF-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a novel medicine injection device for a endoscope, which comprises a needle cylinder, a piston rod, a needle head and an extension tube; the piston rod is sleeved in the needle cylinder; one end of the extension tube is detachably connected with the needle cylinder, and the other end of the extension tube is in threaded connection with the needle head; one end of the extension tube, which faces the needle cylinder, is provided with an elastic sealing piece which is made of antibacterial high polymer materials. The antibacterial polymer material takes polyethyl acrylate and polystyrene as base materials, the antibacterial agent is a silver-carrying molecular sieve, wherein silver sources used are silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, and deionized water and diethylene glycol diethyl ether are taken as mixed solvents; meanwhile, a regulator is added, the regulator is a mixture of 2'4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxy silane, and finally the prepared antibacterial polymer material has strong antibacterial property and still has strong antibacterial property after being treated by acid liquor or alkali liquor.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a medicine injection device for a cavity mirror.
Background
Laparoscopic surgery is a newly developed minimally invasive procedure, also known as "keyhole" surgery. By using the laparoscopic system technology, a doctor only needs to open a plurality of keyhole-shaped small holes around the operation part of the patient, and can intuitively observe the internal condition of the patient in front of a computer screen without opening the abdomen, so that accurate operation is performed, the operation process only needs a short time, and the treatment technology reaches the international advanced level.
In laparoscopic surgery, it is necessary to puncture a tumor or tissue surrounding the tumor with a syringe and inject a drug; the injector comprises a needle cylinder, a piston rod and a needle head; during injection, the injector needs to puncture the tumor or tissues around the tumor through the long tube of the laparoscope poking card and inject the medicine; in order to achieve the purpose, the injector also comprises an extension tube, and the orifice of the extension tube is provided with an elastic sealing sheet; in laparoscopic surgery, the operation needs to be performed under a sterile condition, and meanwhile, the elastic sealing sheet is easy to touch some acidic or alkaline substances in the operation process, so that the elastic sealing sheet still has strong antibacterial property after being soaked in acid liquor or alkali liquor, but no high polymer material still has strong antibacterial property after being soaked in acid liquor or alkali liquor is available in the market at present.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention aims to provide a medicine injection device for a cavity mirror, and an elastic sealing piece on the injection device still has strong antibacterial property after being treated by acid liquor or alkali liquor.
In order to achieve the above purpose, the present invention provides the following technical solutions: a medicine injection device for a endoscope comprises a needle cylinder, a piston rod, a needle head and an extension tube for extending the whole device; the piston rod is sleeved in the needle cylinder; one end of the extension tube is detachably connected with the needle cylinder, and the other end of the extension tube is fixedly connected with the needle head; the side wall of the extension tube is provided with a movable chuck which is connected with the extension tube in a sliding way, and the side wall of the needle cylinder is provided with a first groove for inserting the movable chuck; an elastic sealing piece is arranged at one end of the extension tube, facing the needle cylinder, and is provided with a cross incision, and the elastic sealing piece is made of antibacterial high polymer materials; the antibacterial polymer material comprises the following substances in parts by weight: 80 parts of polyethyl acrylate; 20 parts of polystyrene; 1 part of an antibacterial agent; 2 parts of plasticizer; 3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate; 2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver; 3 parts of a regulator; 10 parts of composite molecular sieve; 75 parts of deionized water; 15 parts of diethylene glycol diethyl ether.
As a further improvement of the invention, a chute is arranged on the extension pipe, the chute is L-shaped, and the movable chuck is connected with the chute in a sliding way; the movable clamp comprises a plug rod, a pull rod and a connecting rod, wherein the plug rod is used for being inserted into the first groove, and the pull rod is convenient for a user to pull; one end of the connecting rod is fixedly connected with the inserted link, and the other end of the connecting rod is fixedly connected with the pull rod; one end of the pull rod, which is away from the connecting rod, extends out of the chute;
the composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
1 part of 3- (methacryloyloxy) propyl trimethoxysilane;
1 part of zinc dibutyl dithiocarbamate;
3 parts of aluminum metaphosphate;
2 parts of lauryl polyoxyethylene ether ammonium sulfate;
5 parts of sodium hydroxide;
90 parts of purified water.
As a further improvement of the invention, a sliding plate is arranged on the part of the pull rod positioned in the chute; the sliding plate is provided with a first spring, one end of the first spring is fixedly connected with the sliding plate, and the other end of the first spring is fixedly connected with the sliding groove; the first spring keeps the inserted link inserted into the first groove;
the preparation method of the composite molecular sieve comprises the following steps:
Step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, 3- (methacryloyloxy) propyl trimethoxysilane, sodium hydroxide and purified water into a reaction container, and stirring and mixing; adding zinc dibutyl dithiocarbamic acid, aluminum metaphosphate and ammonium lauryl polyoxyethylene ether sulfate into a reactor for mixing to prepare a mixed solution;
Step two: placing the mixed solution into an oven with the temperature of 120-150 ℃ for heating reaction for 3-5h; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve;
step three: soaking the microporous molecular sieve in the treating liquid at 60-80 deg.c for 30-50min, washing and stoving to obtain the composite molecular sieve.
As a further improvement of the invention, a limiting component for limiting the movement of the sliding plate is arranged on the inner wall of the chute; a limiting groove is formed in the side wall of the sliding groove, and the limiting assembly is positioned in the limiting groove; the limiting component comprises a hemisphere, a cylinder and a second spring; one end of the cylinder is fixedly connected with the hemispherical body, and the other end of the cylinder is fixedly connected with the second spring; one end of the second spring, which is away from the column body, is fixedly connected with the inner wall of the limit groove; the hemispherical body part extends out of the limit groove; a second groove for inserting the hemispheroids is formed in one side, close to the hemispheroids, of the sliding plate; the second spring keeps the hemispheroids against the inner wall of the second groove; the treatment fluid comprises the following substances in parts by weight:
10 parts of sodium hydroxide;
6 parts of sodium carbonate;
4 parts of trisodium borate;
100 parts of purified water.
As a further improvement of the invention, one end of the pull rod, which is away from the connecting rod, is provided with a fixed plate which is convenient for pulling the movable clamp head, and the cross section area of the fixed plate is larger than that of the chute; the fixing plate is provided with a plurality of salient points which are convenient for increasing friction force;
the regulator is a mixture of 2', 4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane, and the mass ratio of the regulator to the mixture is 3:2:1.
As a further improvement of the invention, the fixing plate is provided with a first through hole, the extension tube is provided with a blind hole, the aperture sizes of the first through hole and the blind hole are the same, and the inner wall of the first through hole and the blind hole are provided with internal threads; the fixing plate is provided with an insertion block for being inserted into the first through hole and the blind hole, and the insertion block is provided with external threads matched with the internal threads;
the preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, mixing uniformly, adding a regulator and a composite molecular sieve, and stirring and mixing to obtain a mixed solution;
S2: placing the mixed solution into an oven at 80-100 ℃ for heat treatment, wherein the heat treatment time is 4-6 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve.
As a further improvement of the present invention, the plasticizer is diisooctyl epoxytetrahydrophthalate.
As a further improvement of the invention, the stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propanediamine, and the mass ratio is 1:1:1.
As a further improvement of the invention, the preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
The invention has the beneficial effects that: the antibacterial agent is a self-made silver-carrying molecular sieve by taking the polyethyl acrylate and the polystyrene as mixed base materials, wherein silver sources used are silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, and two silver-containing substances are used, so that the antibacterial performance of the silver-carrying molecular sieve is improved on one hand, and the acid and alkali resistance of the silver-carrying molecular sieve is improved on the other hand; the silver nitrate is an inorganic substance, and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver contains organic groups such as methyl, so deionized water and diethylene glycol diethyl ether are used as mixed solvents and are used as reaction mediums; as one of the new points of the invention, the composite molecular sieve is a micropore-mesopore composite molecular sieve, by taking tetraethoxysilane and 3- (methacryloyloxy) propyl trimethoxy silane as silicon sources, aluminum metaphosphate as aluminum sources and phosphorus sources, and simultaneously, substances such as zinc dibutyl dithiocarbamate, ammonium lauryl polyoxyethylene ether sulfate and the like are also added; the compound molecular sieve is prepared by a hydrothermal method, and the microporous molecular sieve is prepared firstly, and under the combined action of the substances, the molecular sieve has certain acid and alkali resistance, but has weak capability of adsorbing silver ions due to smaller pore diameter.
By treatment with an alkaline aqueous solution containing sodium hydroxide, sodium carbonate and trisodium borate; during the treatment process, silicon on the edge of the microporous molecular sieve can be dissolved by alkali, so that mesopores are generated; after being treated by the treatment liquid, the microporous molecular sieve is changed into a microporous-mesoporous composite molecular sieve which has good acid and alkali resistance and better silver carrying capacity; as another new creation point of the invention, in order to further strengthen the silver carrying capacity of the molecular sieve, a regulator is added, and the mixture of 2'4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane is selected as the regulator, so that the composite molecular sieve has very strong silver carrying capacity; in addition, the regulator can improve the synergistic effect between the antibacterial agent and other auxiliary agents without adverse effect. The antibacterial agent prepared by the invention has strong antibacterial property and acid and alkali resistance. The finally prepared antibacterial polymer material has strong antibacterial property, and after being treated by acid liquor or alkali liquor, the antibacterial property is still strong, so that the requirements of laparoscopic surgery can be met.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is an enlarged view of a portion of FIG. 1;
FIG. 3 is a further enlarged partial view of FIG. 2;
FIG. 4 is a schematic view of the structure of the extension tube of the present invention after it is disengaged from the syringe;
FIG. 5 is an enlarged view of a portion of FIG. 4;
FIG. 6 is a further enlarged partial view of FIG. 5;
FIG. 7 is a schematic view of a structure of a fixing plate according to the present invention;
fig. 8 is a schematic structural view of the elastic sealing sheet in the present invention.
Reference numerals: 1. a needle cylinder; 11. a first groove; 2. a piston rod; 3. a needle; 4. an extension tube; 41. a chute; 411. a limit groove; 42. a blind hole; 43. an elastic sealing sheet; 431. a cross incision; 5. a movable chuck; 51. a rod; 52. a pull rod; 521. a slip plate; 522. a first spring; 523. a second groove; 53. a connecting rod; 54. a fixing plate; 541. a bump; 542. a first through hole; 55. inserting blocks; 6. a limit component; 61. a hemisphere; 62. a column; 63. and a second spring.
Detailed Description
The invention will now be described in further detail with reference to the drawings and examples. Wherein like parts are designated by like reference numerals.
Referring to fig. 1 to 8, a medicine injection device for a endoscope of the present embodiment comprises a cylinder 1, a piston rod 2, a needle 3 and an extension tube 4 for extending the whole device; the piston rod 2 is sleeved in the needle cylinder 1; one end of the extension tube 4 is detachably connected with the needle cylinder 1, and the other end of the extension tube is fixedly connected with the needle head 3; the side wall of the extension tube 4 is provided with a movable chuck 5, the movable chuck 5 is connected with the extension tube 4 in a sliding way, and the side wall of the needle cylinder 1 is provided with a first groove 11 for inserting the movable chuck 5. The end of the extension tube 4 facing the syringe 1 is provided with an elastic sealing piece 43, the elastic sealing piece 43 is provided with a cross incision 431, and the elastic sealing piece 43 is made of antibacterial high polymer material.
By the technical scheme, in laparoscopic surgery, when the injector is needed to puncture the surface of the tumor and inject the medicine; pulling the movable clamp 5 to connect the extension tube 4 with the needle cylinder 1, and inserting the movable clamp 5 into the first groove 11 of the needle cylinder 1, so that the extension tube 4 and the needle cylinder 1 are fixed together and are not easy to slide relatively; the length of the extension tube 4 is 30-40 cm, the length is convenient for the syringe to pass through the long tube, the length of the needle head 3 is 4mm, the penetration depth can be controlled when the needle head 3 is penetrated conveniently, and the problem that the penetration depth is too deep due to overlong needle head 3 is avoided, so that the patient is injured, the health of the patient can be ensured, and the secondary injury to the patient is avoided. When the old cylinder 1 is removed, separated from the extension rod; the elastic sealing piece 43 seals the pipe orifice at one end of the extension pipe 4 away from the needle head 3, so that sundries cannot enter the extension pipe 4, the health of a patient is guaranteed, and meanwhile, the elastic sealing piece 43 is made of an antibacterial high polymer material, has strong antibacterial property, and further ensures the health of the patient; meanwhile, the cross incision 431 is formed on the elastic sealing piece 43, so that the connection between the extension tube 4 and the needle cylinder 1 is not affected, and the injection device can be used for injecting medicines to tumors and surrounding tissues, so that a patient can be healed early.
As an improved embodiment: the extension pipe 4 is provided with a chute 41, the chute 41 is L-shaped, and the movable chuck 5 is in sliding connection with the inner wall of the chute 41; the movable chuck 5 comprises a pull rod 52 and a connecting rod 53 which are used for being inserted into the first groove 11 and are convenient for a user to pull; one end of the connecting rod 53 is fixedly connected with the inserted rod 51, and the other end of the connecting rod is fixedly connected with the pull rod 52; the end of the pull rod 52 facing away from the connecting rod 53 extends out of the slide groove 41.
Through the technical scheme, the sliding groove 41 comprises a vertical groove and a horizontal groove, the connecting rod 53 is positioned in the vertical groove, the pull rod 52 is positioned in the horizontal groove, and one end of the pull rod 52, which is away from the connecting rod 53, extends out of the horizontal groove; pulling the pull rod 52 away from the connecting rod 53, the insert rod 51 will also move therewith; at this time, the extension tube 4 is connected with the needle cylinder 1, and after the connection is finished; the pull rod 52 is driven to move in the direction close to the connecting rod 53, so that the insert rod 51 moves in the direction close to the inner wall of the first groove 11 until the insert rod 51 is inserted into the first groove 11, so that the needle cylinder 1 and the extension tube are fixed, and the injector can puncture and inject medicine; the structure is simple; meanwhile, when performing abdominal surgery, different medicines are often required to be injected; at this time, only the pull rod 52 needs to be pulled again, the old needle cylinder 1 is removed, the new needle cylinder 1 is connected with the extension tube 4, the pull rod 52 is pulled again, the insert rod 51 is reinserted into the first groove 11, and therefore the new needle cylinder 1 can be fixed with the extension tube 4 again, and the whole operation is very convenient.
As a modified embodiment, the portion of the pull rod 52 located in the chute 41 is provided with a sliding plate 521; the sliding plate 521 is provided with a first spring 522, one end of the first spring 522 is fixedly connected with the sliding plate 521, and the other end is fixedly connected with the inner wall of the chute 41; the first spring 522 keeps the insert rod 51 inserted into the first groove 11.
Through the above technical scheme, when the needle cylinder 1 is installed, a user pulls the pull rod 52 to move in a direction away from the sliding groove 41, and the sliding plate 521 moves along with the pull rod, so that pressure is generated on the first spring 522, and the first spring 522 deforms under the action of the pressure; after the needle cylinder 1 is connected with the extension tube 4, the user stops applying force to the pull rod 52; at this time, the sliding plate 521 has no pressure on the first spring 522, and the sliding plate 521 returns to the initial position under the action of the elastic force of the first spring 522, so that the insert rod 51 is reinserted into the first groove 11, and the extension tube 4 is fixed with the syringe 1; thus, the pull rod 52 is not required to be pushed again manually, and the automatic resetting is realized, so that the labor is saved.
As a modified embodiment, a limiting component 6 for limiting the movement of the sliding plate 521 is arranged on the inner wall of the sliding slot 41; a limiting groove 411 is formed in the side wall of the sliding groove 41, and the limiting component 6 is positioned in the limiting groove 411; the limiting assembly 6 comprises a hemisphere 61, a cylinder 62 and a second spring 63; one end of the column 62 is fixedly connected with the hemispherical body 61, and the other end is fixedly connected with the second spring 63; one end of the second spring 63, which is away from the column 62, is fixedly connected with the inner wall of the limit slot 411; the hemispherical body 61 extends out of the limit slot 411 partially; a second groove 523 for inserting the hemisphere 61 is formed on one side of the sliding plate 521, which is close to the hemisphere 61; the second spring 63 keeps the hemisphere 61 against the inner wall of the second recess 523.
Through the above technical scheme, when the needle cylinder 1 is installed, the user pulls the pull rod 52 to move in the direction away from the sliding groove 41, and the sliding plate 521 moves along with the pull rod; during the moving process of the sliding plate 521, the sliding plate 521 will firstly collide with the hemisphere 61, so that pressure is generated on the hemisphere 61, and one of the components of the pressure is directed toward the second spring 63, so that the second spring 63 will deform under the action of the force, the hemisphere 61 will move toward the direction close to the second spring 63, and the sliding plate 521 can continue to move at this time; because the second groove 523 is arranged on one side of the sliding plate 521, the cross section area of the second groove 523 is semicircular, so that the hemisphere 61 can move towards the direction close to the inner wall of the second groove 523 under the action of the elastic force of the second spring 63 until the hemisphere 61 is in contact with the inner wall of the second groove 523; at this time, even if the pull rod 52 is not forced any more, the pull rod 52 will not return to the initial position, which is equivalent to a limit function to the pull rod 52, and the pull rod 52 does not need to be forced all the time, so that the pull rod 52 is prevented from returning to the initial position due to the elastic force of the first spring 522, the connection and fixation of the needle cylinder 1 and the extension tube 4 are affected, and the labor is saved more conveniently; after the syringe 1 is connected with the extension tube 4, only a large force is needed to drive the pull rod 52 to move towards the direction of the sliding groove 41, the hemispherical body 61 is not inserted into the second groove 523, the pull rod 52 is finally restored to the initial position, the insert rod 51 is also reinserted into the first groove 11, and the extension tube 4 and the syringe 1 are fixed, so that the injection device is convenient for puncturing and injecting medicines.
As a modified specific embodiment, the end of the pull rod 52 away from the connecting rod 53 is provided with a fixed plate 54 for facilitating the pulling of the movable chuck 5, and the cross-sectional area of the fixed plate 54 is larger than that of the chute 41; the fixing plate 54 is provided with a plurality of salient points 541 for increasing friction force.
Through the technical scheme, when the needle cylinder 1 is installed, the movable clamp head 5 can be moved only by pulling the fixing plate 54, and compared with the pulling of the pull rod 52, the movable clamp head is more convenient to move the inserting rod 51; meanwhile, as the convex points 541 are arranged on the fixing plate 54, the convex points 541 can play a role in skid resistance, so that the force application by a user is facilitated; when the needle cylinder 1 is installed, the fixing plate 54 is only required to be driven to move towards the direction close to the extension tube 4 until the fixing plate 54 is abutted against the side wall of the extension tube 4; since the cross section area of the fixing plate 54 is larger than that of the chute 41, the fixing plate 54 can block the notch of the chute 41, prevent sundries from entering the chute 41 and influence the movement of the pull rod 52, and the invention is more improved.
As a modified embodiment, the fixing plate 54 is provided with a first through hole 542, the extension tube 4 is provided with a blind hole 42, the first through hole 542 and the blind hole 42 have the same pore size, and the inner wall is provided with internal threads; the fixing plate 54 is provided with an insert block 55 for inserting the first through hole 542 and the blind hole 42, and the insert block 55 is provided with external threads adapted to the internal threads.
Through the above technical scheme, after the needle cylinder 1 is fixed with the extension tube 4, the insert 55 is sequentially inserted into the first through hole 542 and the blind hole 42, so that the fixing plate 54 cannot move any more even if the fixing plate 54 is pulled; the fixing plate 54 is prevented from moving due to unexpected situations, so that the extension tube 4 and the needle cylinder 1 relatively move to influence the penetration of the injector and the injection of the medicine, and the stability of the invention is improved; when the needle cylinder 1 needs to be replaced, the insert block 55 is only required to be removed, and the fixed block can be pulled again, so that the movable chuck 5 moves.
Material example one:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate;
2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver;
3 parts of a regulator;
10 parts of composite molecular sieve;
75 parts of deionized water;
15 parts of diethylene glycol diethyl ether.
The composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
1 part of 3- (methacryloyloxy) propyl trimethoxysilane;
1 part of zinc dibutyl dithiocarbamate;
3 parts of aluminum metaphosphate;
2 parts of lauryl polyoxyethylene ether ammonium sulfate;
5 parts of sodium hydroxide;
90 parts of purified water.
The preparation method of the composite molecular sieve comprises the following steps:
Step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, 3- (methacryloyloxy) propyl trimethoxy silane, sodium hydroxide and purified water into a reaction vessel, and stirring and mixing for 15min at a stirring speed of 200 rad/min; adding zinc dibutyl dithiocarbamic acid, aluminum metaphosphate and ammonium lauryl polyoxyethylene ether sulfate into a reactor, stirring and mixing for 20min to prepare a mixed solution;
Step two: putting the mixed solution into an oven with the temperature of 135 ℃ for heating reaction for 4 hours; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve.
Step three: and (3) soaking the microporous molecular sieve in a treatment liquid for 40min, wherein the temperature of the treatment liquid is 70 ℃, washing and drying after the soaking is finished, and thus the composite molecular sieve is obtained.
The treatment fluid comprises the following substances in parts by weight:
10 parts of sodium hydroxide;
6 parts of sodium carbonate;
4 parts of trisodium borate;
100 parts of purified water.
The regulator is a mixture of 2', 4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane, and the mass ratio of the regulator to the mixture is 3:2:1.
The preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, and stirring and mixing for 5min at a stirring speed of 300 rad/min; adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, stirring and mixing for 10min, adding a regulator and a composite molecular sieve after uniformly mixing, and stirring and mixing for 15min to obtain a mixed solution;
s2: putting the mixed solution into a baking oven at 90 ℃ for heat treatment, wherein the heat treatment time is 5 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve;
the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Material comparative example one:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
2 parts of plasticizer;
3 parts of stabilizer;
the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: uniformly mixing the polyethyl acrylate, the polystyrene, the plasticizer and the stabilizer, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Material comparative example two:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate;
2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver;
10 parts of composite molecular sieve;
75 parts of deionized water;
15 parts of diethylene glycol diethyl ether.
The composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
1 part of 3- (methacryloyloxy) propyl trimethoxysilane;
1 part of zinc dibutyl dithiocarbamate;
3 parts of aluminum metaphosphate;
2 parts of lauryl polyoxyethylene ether ammonium sulfate;
5 parts of sodium hydroxide;
90 parts of purified water.
The preparation method of the composite molecular sieve comprises the following steps:
Step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, 3- (methacryloyloxy) propyl trimethoxy silane, sodium hydroxide and purified water into a reaction vessel, and stirring and mixing for 15min at a stirring speed of 200 rad/min; adding zinc dibutyl dithiocarbamic acid, aluminum metaphosphate and ammonium lauryl polyoxyethylene ether sulfate into a reactor, stirring and mixing for 20min to prepare a mixed solution;
Step two: putting the mixed solution into an oven with the temperature of 135 ℃ for heating reaction for 4 hours; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve.
Step three: and (3) soaking the microporous molecular sieve in a treatment liquid for 40min, wherein the temperature of the treatment liquid is 70 ℃, washing and drying after the soaking is finished, and thus the composite molecular sieve is obtained.
The treatment fluid comprises the following substances in parts by weight:
10 parts of sodium hydroxide;
6 parts of sodium carbonate;
4 parts of trisodium borate;
100 parts of purified water.
The preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, and stirring and mixing for 5min at a stirring speed of 300 rad/min; adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, stirring and mixing for 10min, adding a composite molecular sieve after uniformly mixing, and stirring and mixing for 15min to obtain a mixed solution;
s2: putting the mixed solution into a baking oven at 90 ℃ for heat treatment, wherein the heat treatment time is 5 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve;
the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Material comparative example three:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate;
2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver;
3 parts of a regulator;
10 parts of microporous molecular sieve;
75 parts of deionized water;
15 parts of diethylene glycol diethyl ether.
The composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
1 part of 3- (methacryloyloxy) propyl trimethoxysilane;
1 part of zinc dibutyl dithiocarbamate;
3 parts of aluminum metaphosphate;
2 parts of lauryl polyoxyethylene ether ammonium sulfate;
5 parts of sodium hydroxide;
90 parts of purified water.
The preparation method of the composite molecular sieve comprises the following steps:
Step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, 3- (methacryloyloxy) propyl trimethoxy silane, sodium hydroxide and purified water into a reaction vessel, and stirring and mixing for 15min at a stirring speed of 200 rad/min; adding zinc dibutyl dithiocarbamic acid, aluminum metaphosphate and ammonium lauryl polyoxyethylene ether sulfate into a reactor, stirring and mixing for 20min to prepare a mixed solution;
Step two: putting the mixed solution into an oven with the temperature of 135 ℃ for heating reaction for 4 hours; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve.
The regulator is a mixture of 2', 4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane, and the mass ratio of the regulator to the mixture is 3:2:1.
The preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, and stirring and mixing for 5min at a stirring speed of 300 rad/min; adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, stirring and mixing for 10min, adding a regulator and a microporous molecular sieve after uniformly mixing, and stirring and mixing for 15min to obtain a mixed solution;
s2: putting the mixed solution into a baking oven at 90 ℃ for heat treatment, wherein the heat treatment time is 5 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve;
the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Material comparative example four:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate;
2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver;
3 parts of a regulator;
10 parts of composite molecular sieve;
75 parts of deionized water;
15 parts of diethylene glycol diethyl ether.
The composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
3 parts of aluminum metaphosphate;
5 parts of sodium hydroxide;
90 parts of purified water.
The preparation method of the composite molecular sieve comprises the following steps:
step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, sodium hydroxide and purified water into a reaction vessel, and stirring and mixing for 15min at a stirring speed of 200 rad/min; adding aluminum metaphosphate into a reactor, stirring and mixing for 20min to prepare a mixed solution;
Step two: putting the mixed solution into an oven with the temperature of 135 ℃ for heating reaction for 4 hours; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve.
Step three: and (3) soaking the microporous molecular sieve in a treatment liquid for 40min, wherein the temperature of the treatment liquid is 70 ℃, washing and drying after the soaking is finished, and thus the composite molecular sieve is obtained.
The treatment fluid comprises the following substances in parts by weight:
10 parts of sodium hydroxide;
6 parts of sodium carbonate;
4 parts of trisodium borate;
100 parts of purified water.
The regulator is a mixture of 2', 4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane, and the mass ratio of the regulator to the mixture is 3:2:1.
The preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, and stirring and mixing for 5min at a stirring speed of 300 rad/min; adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, stirring and mixing for 10min, adding a regulator and a composite molecular sieve after uniformly mixing, and stirring and mixing for 15min to obtain a mixed solution;
s2: putting the mixed solution into a baking oven at 90 ℃ for heat treatment, wherein the heat treatment time is 5 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve;
the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Comparative example five materials:
the antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
The antibacterial agent is zeolite silver,
The plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
The stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
The preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
Antibacterial test: accurately weighing 0.1g of the sample, adding the sample into a triangular flask filled with 99mL of sterile water, and separating the sample by ultrasonic waves for 20min. 1mL of the bacterial suspension was added at a concentration of 107 CFU/mL. Another flask containing 99mL of sterile water was used as a blank, and only 1mL of the bacterial suspension was added. Placing the triangular flask in a shaking incubator, and shaking culturing at 37deg.C and 200r/min for 30min. 0.2mL of the mixed solution is taken in each triangular flask, diluted appropriately, spread on a culture dish, cultured at a constant temperature of 35 ℃ for 48-72 hours, and counted. The two groups of samples are respectively subjected to 3 parallel experiments, and the antibacterial rate is calculated according to the following formula, wherein R= [ (A-B)/A ]. Times.100%
R-antibacterial rate;
a-average colony count of the blank group;
b-average colony count of the antibacterial sample to be tested was added.
The strain is selected from Staphylococcus aureus and Escherichia coli.
And (3) immersing the sample in an acetic acid solution with the pH of 5 for 1h, and then detecting the antibacterial property of the sample by using the antibacterial property detection method.
After the sample was immersed in sodium bicarbonate solution having a pH of 8.3 for 1 hour, the antibacterial property of the sample was measured by the above-mentioned antibacterial property measuring method.
The antibacterial high polymer material provided by the invention takes the polyethyl acrylate and the polystyrene as the mixed base materials, so that the high polymer material has higher strength and higher toughness, and can meet the requirements of abdominal surgery.
As the key point of the invention, an antibacterial agent is added into the polyethyl acrylate and the polystyrene, the antibacterial agent is a self-made silver-carrying molecular sieve, wherein the silver sources used are silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, and two silver-containing substances are used, so that on one hand, the antibacterial performance of the silver-carrying molecular sieve is improved, and on the other hand, the acid and alkali resistance of the silver-carrying molecular sieve is improved; the silver nitrate is an inorganic substance, and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver contains organic groups such as methyl, so deionized water and diethylene glycol diethyl ether are used as mixed solvents and are used as reaction mediums; as one of the new points of the invention, the composite molecular sieve is a micropore-mesopore composite molecular sieve, by taking tetraethoxysilane and 3- (methacryloyloxy) propyl trimethoxy silane as silicon sources, aluminum metaphosphate as aluminum sources and phosphorus sources, and simultaneously, substances such as zinc dibutyl dithiocarbamate, ammonium lauryl polyoxyethylene ether sulfate and the like are also added; the compound molecular sieve is prepared by a hydrothermal method, and the microporous molecular sieve is prepared firstly, and under the combined action of the substances, the molecular sieve has certain acid and alkali resistance, but has weak capability of adsorbing silver ions due to smaller pore diameter.
By treatment with an alkaline aqueous solution containing sodium hydroxide, sodium carbonate and trisodium borate; during the treatment process, silicon on the edge of the microporous molecular sieve can be dissolved by alkali, so that mesopores are generated; after being treated by the treatment liquid, the microporous molecular sieve is changed into a microporous-mesoporous composite molecular sieve which has good acid and alkali resistance and better silver carrying capacity; as another new creation point of the invention, in order to further strengthen the silver carrying capacity of the molecular sieve, a regulator is added, and the mixture of 2'4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane is selected as the regulator, so that the composite molecular sieve has very strong silver carrying capacity; in addition, the regulator can improve the synergistic effect between the antibacterial agent and other auxiliary agents without adverse effect. The antibacterial agent prepared by the invention has strong antibacterial property and acid and alkali resistance. The finally prepared antibacterial polymer material has strong antibacterial property, and after being treated by acid liquor or alkali liquor, the antibacterial property is still strong, so that the requirements of laparoscopic surgery can be met.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (4)
1. A medicine injection device for a cavity mirror, which is characterized in that: comprises a needle cylinder (1), a piston rod (2), a needle head (3) and an extension tube (4) for extending the whole device; the piston rod (2) is sleeved in the needle cylinder (1); one end of the extension tube (4) is detachably connected with the needle cylinder (1), and the other end of the extension tube is fixedly connected with the needle head (3); a movable chuck (5) is arranged on the side wall of the extension tube (4), the movable chuck (5) is connected with the extension tube (4) in a sliding way, and a first groove (11) for inserting the movable chuck (5) is arranged on the side wall of the needle cylinder (1); an elastic sealing piece (43) is arranged at one end of the extension tube (4) facing the needle cylinder (1), a cross incision (431) is arranged on the elastic sealing piece (43), and the elastic sealing piece (43) is made of antibacterial high polymer materials;
The antibacterial polymer material comprises the following substances in parts by weight:
80 parts of polyethyl acrylate;
20 parts of polystyrene;
1 part of an antibacterial agent;
2 parts of plasticizer;
3 parts of stabilizer;
the antibacterial agent is a silver-carrying molecular sieve, and the silver-carrying molecular sieve comprises the following substances in parts by weight:
10 parts of silver nitrate;
2 parts of (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver;
3 parts of a regulator;
10 parts of composite molecular sieve;
75 parts of deionized water;
15 parts of diethylene glycol diethyl ether;
A chute (41) is arranged on the extension pipe (4), the chute (41) is L-shaped, and the movable clamp head (5) is in sliding connection with the chute (41); the movable clamp head (5) comprises a plug rod (51) which is used for being inserted into the first groove (11), a pull rod (52) which is convenient for a user to pull, and a connecting rod (53); one end of the connecting rod (53) is fixedly connected with the inserted link (51), and the other end of the connecting rod is fixedly connected with the pull rod (52); one end of the pull rod (52) deviating from the connecting rod (53) extends out of the chute (41);
the composite molecular sieve comprises the following substances in parts by weight:
4 parts of tetraethyl orthosilicate;
1 part of 3- (methacryloyloxy) propyl trimethoxysilane;
1 part of zinc dibutyl dithiocarbamate;
3 parts of aluminum metaphosphate;
2 parts of lauryl polyoxyethylene ether ammonium sulfate;
5 parts of sodium hydroxide;
90 parts of purified water;
a sliding plate (521) is arranged on the part of the pull rod (52) positioned in the chute (41); a first spring (522) is arranged on the sliding plate (521), one end of the first spring (522) is fixedly connected with the sliding plate (521), and the other end of the first spring is fixedly connected with the sliding groove (41); the first spring (522) keeps the insert rod (51) inserted into the first groove (11); the preparation method of the composite molecular sieve comprises the following steps:
Step one: preparing raw materials according to a set weight percentage, adding tetraethyl orthosilicate, 3- (methacryloyloxy) propyl trimethoxysilane, sodium hydroxide and purified water into a reaction container, and stirring and mixing; adding zinc dibutyl dithiocarbamic acid, aluminum metaphosphate and ammonium lauryl polyoxyethylene ether sulfate into a reactor for mixing to prepare a mixed solution;
Step two: placing the mixed solution into an oven with the temperature of 120-150 ℃ for heating reaction for 3-5h; after the reaction is finished, separating, washing and drying the product to obtain carrier raw powder, and then burning the carrier raw powder to obtain the microporous molecular sieve;
Step three: soaking the microporous molecular sieve in a treatment solution for 30-50min, wherein the temperature of the treatment solution is 60-80 ℃, washing and drying after the soaking is finished to obtain a composite molecular sieve;
A limiting component (6) for limiting the sliding plate (521) to move is arranged on the inner wall of the sliding groove (41); a limiting groove (411) is formed in the side wall of the sliding groove (41), and the limiting assembly (6) is positioned in the limiting groove (411); the limiting component (6) comprises a hemisphere (61), a column body (62) and a second spring (63); one end of the column body (62) is fixedly connected with the hemispherical body (61), and the other end of the column body is fixedly connected with the second spring (63); one end of the second spring (63) deviating from the column body (62) is fixedly connected with the inner wall of the limit groove (411); a limiting groove (411) extends out of a part of the hemispherical body (61); a second groove (523) for inserting the hemispheroid (61) is formed in one side, close to the hemispheroid (61), of the sliding plate (521); the second spring (63) keeps the hemispheroids (61) against the inner wall of the second groove (523);
The treatment fluid comprises the following substances in parts by weight:
10 parts of sodium hydroxide;
6 parts of sodium carbonate;
4 parts of trisodium borate;
100 parts of purified water;
One end of the pull rod (52) deviating from the connecting rod (53) is provided with a fixed plate (54) which is convenient for pulling the movable clamp head (5), and the cross section area of the fixed plate (54) is larger than that of the chute (41); the fixed plate (54) is provided with a plurality of salient points (541) which are convenient for increasing friction force;
the regulator is a mixture of 2', 4' -difluoro-2- [1- (1H-1, 2, 4-triazolyl) ] acetophenone, sodium dihydroxycetyl phosphate and diethylenetriamine propyl trimethoxysilane, and the mass ratio of the regulator to the mixture is 3:2:1;
The fixing plate (54) is provided with a first through hole (542), the extension tube (4) is provided with a blind hole (42), the first through hole (542) and the blind hole (42) have the same pore size, and the inner wall is provided with internal threads; the fixing plate (54) is provided with an insertion block (55) for being inserted into the first through hole (542) and the blind hole (42), and the insertion block (55) is provided with external threads matched with the internal threads;
the preparation method of the antibacterial agent comprises the following steps:
S1: preparing raw materials according to a set weight percentage, adding deionized water and diethylene glycol diethyl ether into a reactor, stirring and mixing, adding silver nitrate and (6,6,7,7,8,8,8-heptafluoro-2, 2-dimethyl-3, 5-octanedioic acid) silver, mixing uniformly, adding a regulator and a composite molecular sieve, and stirring and mixing to obtain a mixed solution;
S2: placing the mixed solution into an oven at 80-100 ℃ for heat treatment, wherein the heat treatment time is 4-6 hours; after the treatment is finished, separating, washing and drying the product to obtain the silver-carrying molecular sieve.
2. A drug injection device for endoscopy according to claim 1 and wherein: the plasticizer is epoxy tetrahydrophthalic acid diisooctyl ester.
3. A drug injection device for endoscopy according to claim 1 and wherein: the stabilizer is a mixture of triethoxy-1H, 2H-tridecafluoro-N-octyl silane, resorcinol diglycidyl ether and N- (2-ethylamino) -1, 3-propylene diamine, and the mass ratio of the stabilizer to the stabilizer is 1:1:1.
4. A drug injection device for endoscopy according to claim 1 and wherein: the preparation method of the antibacterial polymer material comprises the following steps: firstly, mixing the polyethyl acrylate, the polystyrene and the plasticizer to obtain a first mixture; then mixing an antibacterial agent and a stabilizing agent to obtain a second mixture; then uniformly mixing the first mixture and the second mixture, and adding the mixture into a double-screw extruder for extrusion to obtain plastic particles; the temperature of the charging barrel is 180 ℃ in the first area, 190 ℃ in the second area, 200 ℃ in the third area, 200 ℃ in the fourth area, 210 ℃ in the fifth area and 215 ℃ in the sixth area.
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| CN201811075254.4A CN109200446B (en) | 2018-09-14 | 2018-09-14 | Medicine injection device for endoscope |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811075254.4A CN109200446B (en) | 2018-09-14 | 2018-09-14 | Medicine injection device for endoscope |
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| CN109200446B true CN109200446B (en) | 2024-05-14 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1097671A (en) * | 1964-04-10 | 1968-01-03 | Willows Francis Ltd | Improvements in and relating to cartridge syringes |
| WO2005006991A2 (en) * | 2003-07-18 | 2005-01-27 | Chiroxia Limited | Device and method for fallopian tube occlusion |
| WO2018003777A1 (en) * | 2016-06-30 | 2018-01-04 | 株式会社根本杏林堂 | Mixing device, mixing tube, injection system, and method for producing mixing device |
| CN209405474U (en) * | 2018-09-14 | 2019-09-20 | 温州市中心医院 | A kind of novel cavity mirror medicament injection apparatus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1436036A4 (en) * | 2001-10-15 | 2006-07-19 | Medical Components Inc | Catheter with detachable hub |
| US9233208B2 (en) * | 2012-11-29 | 2016-01-12 | Becton, Dickinson And Company | Methods and apparatus for disinfecting and reflux prevention flush syringe assembly |
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2018
- 2018-09-14 CN CN201811075254.4A patent/CN109200446B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1097671A (en) * | 1964-04-10 | 1968-01-03 | Willows Francis Ltd | Improvements in and relating to cartridge syringes |
| WO2005006991A2 (en) * | 2003-07-18 | 2005-01-27 | Chiroxia Limited | Device and method for fallopian tube occlusion |
| WO2018003777A1 (en) * | 2016-06-30 | 2018-01-04 | 株式会社根本杏林堂 | Mixing device, mixing tube, injection system, and method for producing mixing device |
| CN209405474U (en) * | 2018-09-14 | 2019-09-20 | 温州市中心医院 | A kind of novel cavity mirror medicament injection apparatus |
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