CN109187647A - A kind of chiral molecules detection module based on Hall effect - Google Patents
A kind of chiral molecules detection module based on Hall effect Download PDFInfo
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- CN109187647A CN109187647A CN201811264270.8A CN201811264270A CN109187647A CN 109187647 A CN109187647 A CN 109187647A CN 201811264270 A CN201811264270 A CN 201811264270A CN 109187647 A CN109187647 A CN 109187647A
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Abstract
The present invention relates to a kind of chiral molecules detection module based on Hall effect, including basal layer, the metal layer being formed on the basal layer, and it is formed in the graphene layer of at least partly top of the metal layer；The metal layer includes metal plate layer and metal aperture, and the metal aperture of horizontal direction arrangement is provided with above metal plate layer, and metal aperture is internally provided with one layer of metal particle layer.The left and right settings of the metal layer has electrode, and the front and rear sides of the metal layer are provided with magnetic field perpendicular to current direction.Chiral molecules is instilled in the module, is irradiated with circularly polarized light, since there is a pair of of isomers different chiralitys can cause metal layer that different responses occurs when circularly polarized light is irradiated to the module, the Hall voltage for causing Hall effect to generate is different.Therefore, the value of the Hall voltage measured with the module characterizes the characteristic of chiral molecules, and the module detection sensitivity is high and detection method is simple to operation.
Description
Technical field
The present invention relates to chiral molecules detector technologies fields, and in particular to a kind of chiral molecules inspection based on Hall effect
Survey module.
Background technique
Hall effect is one kind of galvanomagnetic-effect, this phenomenon be Hall (E.H.Hall, 1855-1938) in 1879
It is found when studying the conductive mechanism of metal, finds that semiconductor, conductive fluid etc. also have this effect later.When electric current perpendicular to
When external magnetic field passes through conductor, carrier deflects, and one additional electric field can be generated perpendicular to electric current and magnetic direction, thus
The both ends of conductor generate potential difference, this phenomenon is exactly Hall effect.The Hall sensor energy as made of using Hall effect
Direction and the size for enough detecting magnetic field, are widely used in industrial automation technology, detection technique and information processing etc., and
And the Hall sensor based on semiconductor is widely used.
Chirality widely exists in nature, is a kind of important symmetrical feature.For a pair of of chiral isomer, when it
Content it is equal when, irradiated with a branch of circularly polarized light, generate different absorptions, how using Hall effect to realize chiral point
The detection of son is always the hot spot of this field research, is at present still the technological difficulties that do not capture.
Summary of the invention
The problem to be solved in the present invention is that the detection of chiral molecules chirality how is realized using Hall effect.
For this purpose, the present invention provides a kind of chiral molecules detection module based on Hall effect, including basal layer, it is formed in
Metal layer on the basal layer, and it is formed in the graphene layer of the metal layer；The left and right settings of the metal layer
There is electrode；The front and rear sides of the metal layer are provided with magnetic field perpendicular to current direction；The metal layer include metal plate layer and
Metal aperture, the metal aperture of horizontal direction arrangement is provided with above metal plate layer, and metal aperture is internally provided with one layer of metal
Granulosa.
Further, the direction of the metal aperture is horizontal cross setting.
Further, the direction of the metal aperture is horizontal longitudinally disposed.
Further, the shape in the metal aperture section can be semicircle, rectangle, zigzag or the shapes such as trapezoidal.
Further, the graphene film in it is band-like be laid in except metal aperture metal layer formed graphene
Layer.
Further, the basal layer is made of silicon or earth silicon material.
Further, the metal layer is made of gold or ag material.
Further, the metal particle layer is made of gold or ag material.
Further, the radius of the metallic particles in the metal particle layer is 30~50 nm.
A method of it is detected using the chiral molecules detection module based on Hall effect is chiral, including following step
It is rapid:
(1) the chiral molecules solution of known chirality is instilled in the chiral molecules detection module based on Hall effect, it is slight to shake
After swinging, surfactant is added, connection molecule makes chiral molecules form preferable assembling with the metal layer in module；
(2) electrode switch, externally-applied magnetic field are opened, magnetic direction is parallel to metal layer and perpendicular to current direction, will be outside the module
Connect voltmeter；
(3) with circularly polarized light along the front illuminated of the module module；
(4) numerical value on voltmeter is observed, that is, measures the voltage range where the chiral molecules of the chirality；
(5) step (1)~(4) are repeated several times, measure the voltage range of left and right handed chiral molecules respectively；
(6) the step of by chiral molecules to be measured according to above-mentioned (1)~(4), measures the size of the voltage generated based on Hall effect；
(7) compare surveyed voltage and above-mentioned chiral molecules voltage range, comparison obtains the chirality of the chiral molecules to be measured.
Beneficial effects of the present invention: this chiral molecules detector based on Hall effect provided by the invention, pass through by
The module is placed in chiral molecules to be measured, is irradiated with circularly polarized light, since different chiral isomers is to the sound of circularly polarized light
Answer difference, the Localized field enhancement that causes chiral molecules to generate in the metal layer is different, cause carrier concentration in metal layer and
Migration rate also can be different, according to Hall effect, the numerical value for directly resulting in external voltage table is different, characterize chiral molecules with this
Chiral properties.Secondly, we can be enhanced light and chiral molecules act on by the way that metal aperture and metallic particles is arranged in metal layer
The difference of different chiralitys is amplified, is conducive to detect by the local light of generation.Also, we by being arranged stone on the metal layer
The spirit of the detection module can be improved since graphene film has very high carrier concentration and mobility in black alkene layer
Sensitivity.Eventually by the detection to voltage swing, to reflect the chirality of chiral molecules.The chiral molecules that the invention provides detects mould
Block is not only simple in structure, and sensitivity is high, has extraordinary detection effect.
The present invention is described in further details below with reference to attached drawing.
Detailed description of the invention
Fig. 1 is the chiral molecules detection module schematic diagram one in embodiment 1 based on Hall effect.
Fig. 2 is the chiral molecules detection module schematic diagram two in embodiment 1 based on Hall effect.
Fig. 3 is the chiral molecules detection module schematic diagram three in embodiment 1 based on Hall effect.
Fig. 4 is the chiral molecules detection module schematic diagram four in embodiment 1 based on Hall effect.
In figure: 1, basal layer；2, metal layer；21, metal plate layer；22, metal aperture；3, graphene layer；4, electrode；5, metal
Stratum granulosum.
Specific embodiment
Reach the technical means and efficacy that predetermined purpose is taken for the present invention is further explained, below in conjunction with attached drawing and reality
Example is applied to a specific embodiment of the invention, structure feature and its effect, detailed description are as follows.
Embodiment 1
In order to realize the detection of chiral molecule polarization characteristic using Hall effect.Present embodiments provide a kind of institute picture 1-4
The chiral molecules detection module based on Hall effect shown, including basal layer 1, the metal layer 2 being formed on the basal layer 1,
And it is formed in the graphene layer 3 of at least partly top of the metal layer 2；The metal layer 2 includes metal plate layer 21 and gold
Belong to hole 22, the top of metal plate layer 21 is provided with the metal aperture 22 of horizontal direction arrangement, and metal aperture 22 is internally provided with one layer
Metal particle layer 5.
The direction of the metal aperture 22 is horizontal cross setting, and the direction of the metal aperture 22 may be that horizontal longitudinal direction is set
It sets.The shape in 22 section of metal aperture can be semicircle, rectangle, zigzag or the shapes such as trapezoidal.
A pair of of chiral isomer is different from the response that same kind circularly polarized light occurs, due to chiral molecules and circularly polarized light
Response is smaller, therefore in this embodiment, and circularly polarized light and metal layer act on, and generates Localized field enhancement, the local fields of enhancing are again
Chiral molecules is acted on, the interaction of chiral molecules and circularly polarized light will be enhanced.Further, different chiral molecules and circle are inclined
The interaction of vibration light can act on metal layer again, and metal layer is caused to generate different responses, change the dense of metal layer carrier
Degree and carrier's rate.
The left and right settings of the metal layer 2 has electrode 4, and the front and rear sides of the metal layer 2 are arranged perpendicular to current direction
There is magnetic field.The magnetic field perpendicular to current direction by the way that electrode 4 is arranged on the metal layer and being parallel to the setting of metal layer 2, makes
Entire embodiment module composition hall effect sensor, by external voltage table, real-time collecting and processing Hall voltage, so that it may
Detect the Chiral effects of chiral molecules.
The basal layer 1 is made of silicon or earth silicon material.
The metal layer 2 and metal particle layer 6 are made of the metal material of well conducting；Preferential is selected as gold or silvery
At.The radius of metallic particles in the metal particle layer 6 is 30~50 nm.
The graphene film in it is band-like be laid in except metal aperture 22 metal layer 2 above formed graphene layer 3.Graphite
Alkene layer 3 not only has high carrier concentration and electron mobility, can effectively improve the sensitivity of the light detection module, and by its
It is arranged on metal layer 2, circularly polarized light can be increased and be irradiated to the difference for generating response in the structure, keep testing result brighter
It is aobvious.Graphene has good optical characteristics, can change its optical property by changing its applied voltage.By changing graphite
The bias-voltage of 3 two sides of alkene layer, makes its fermi level change, to change its effective refractive index, is finally reached change
The result of its Hall voltage.
When actual use, electrode 4 is connect with external power supply, to give 2 on-load voltage V of metal layer, circularly polarized light
The incident structure, generates different responses from chiral molecules, different so as to cause the carrier concentration and migration rate of metal layer,
Finally make Hall voltage of the metal layer 2 between magnetic field different, by detecting corresponding curent change, realizes to different chiralitys
The detection of molecule.
In conclusion being somebody's turn to do the chiral molecules detection module based on Hall effect, which is irradiated by circularly polarized light, is caused
The response of the chiral molecules of different characteristics is different, leads to carrier concentration and mobility difference in metal layer 2, and then pass through electrode
The Hall voltage measured also can be different, and the characteristic of chiral molecules is characterized with this.By the way that graphene layer is added, to increase carrier
Concentration and mobility, to improve the sensitivity of entire light detection module.
Embodiment 2
In order to realize the detection of chiral molecular characterization using Hall effect, present embodiments provide a kind of using based on Hall effect
The chiral method detected of the chiral molecules detection module answered, comprising the following steps:
(1) chiral molecules of known chirality is instilled in the chiral molecules detection module based on Hall effect, after slight oscillatory,
Surfactant is added, connection molecule makes chiral molecules form preferable assembling with the metal layer in module；
(2) electrode switch, externally-applied magnetic field are opened, magnetic direction is parallel to metal layer and perpendicular to current direction, will be outside the module
Connect voltmeter；
(3) with circularly polarized light along the front illuminated of the module module；(4) numerical value on voltmeter is observed, that is, measures the chirality
Voltage range where chiral molecules；
(5) step (1)~(4) are repeated several times, measure the voltage range of left and right handed chiral molecules respectively；
(6) the step of by chiral molecules to be measured according to above-mentioned (1)~(4), measures the size of the voltage generated based on Hall effect；
(7) compare surveyed voltage and above-mentioned chiral molecules voltage range, comparison obtains the chirality of the chiral molecules to be measured.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (10)
1. a kind of chiral molecules detection module based on Hall effect, it is characterised in that: including basal layer (1), be formed in described
Metal layer (2) on basal layer (1), and it is formed in the graphene layer (3) above the metal layer (2)；
The left and right settings of the metal layer (2) has electrode (4)；The front and rear sides of the metal layer (2) are set perpendicular to current direction
It is equipped with magnetic field；
The metal layer (2) includes metal plate layer (21) and metal aperture (22), and metal plate layer is provided with level side above (21)
To the metal aperture (22) of arrangement, metal aperture (22) is internally provided with one layer of metal particle layer (5).
2. a kind of chiral molecules detection module based on Hall effect as described in claim 1, it is characterised in that: the metal
The direction in hole (22) is horizontal cross setting.
3. a kind of chiral molecules detection module based on Hall effect as described in claim 1, it is characterised in that: the metal
The direction in hole (22) is horizontal longitudinally disposed.
4. a kind of chiral molecules detection module based on Hall effect as claimed in claim 2 or claim 3, it is characterised in that: described
The shape in metal aperture (22) section can be semicircle, rectangle, zigzag or the shapes such as trapezoidal.
5. a kind of chiral molecules detection module based on Hall effect as claimed in claim 4, it is characterised in that: the graphite
Alkene film in it is band-like be laid in except metal aperture (22) metal layer (2) above formed graphene layer (3).
6. a kind of chiral molecules detection module based on Hall effect as claimed in claim 5, it is characterised in that: the substrate
Layer (1) is made of silicon or earth silicon material.
7. a kind of chiral molecules detection module based on Hall effect as claimed in claim 6, it is characterised in that: the metal
Layer (2) is made of gold or ag material.
8. a kind of chiral molecules detection module based on Hall effect as claimed in claim 7, it is characterised in that: the metal
Stratum granulosum (5) is made of gold or ag material.
9. a kind of chiral molecules detection module based on Hall effect as claimed in claim 8, it is characterised in that: the metal
The radius of metallic particles in stratum granulosum (5) is 30~50 nm.
10. a kind of utilize the chiral method detected of chiral molecules detection module based on Hall effect, including following step
It is rapid:
(1) chiral molecules of known chirality is instilled in the chiral molecules detection module based on Hall effect, after slight oscillatory,
Surfactant is added, connection molecule makes chiral molecules form preferable assembling with the metal layer in module；
(2) electrode switch, externally-applied magnetic field are opened, magnetic direction is parallel to metal layer and perpendicular to current direction, will be outside the module
Connect voltmeter；
(3) with circularly polarized light along the front illuminated of the module module；
(4) numerical value on voltmeter is observed, that is, measures the voltage range where the chiral molecules of the chirality；
(5) step (1)~(4) are repeated several times, measure the voltage range of left and right handed chiral molecules respectively；
(6) the step of by chiral molecules to be measured according to above-mentioned (1)~(4), measures the size of the voltage generated based on Hall effect；
(7) compare surveyed voltage and above-mentioned chiral molecules voltage range, comparison obtains the chirality of the chiral molecules to be measured.
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| CN201811264270.8A CN109187647A (en) | 2018-10-29 | 2018-10-29 | A kind of chiral molecules detection module based on Hall effect |
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| CN201811264270.8A CN109187647A (en) | 2018-10-29 | 2018-10-29 | A kind of chiral molecules detection module based on Hall effect |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113125547A (en) * | 2020-01-16 | 2021-07-16 | 同济大学 | Chiral compound detection method |
| CN113125548A (en) * | 2020-01-16 | 2021-07-16 | 同济大学 | Chiral compound detection system |
| CN113826003A (en) * | 2019-05-16 | 2021-12-21 | 公立大学法人大阪 | Chiral detection device, chiral detection method, separation device, separation method, and chiral substance device |
| CN114112926A (en) * | 2021-11-26 | 2022-03-01 | 西安邮电大学 | Carbon nanotube chiral molecule detection device |
| EP4312039A1 (en) * | 2022-07-26 | 2024-01-31 | Hitachi, Ltd. | Biosensing apparatus |
-
2018
- 2018-10-29 CN CN201811264270.8A patent/CN109187647A/en not_active Withdrawn
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113826003A (en) * | 2019-05-16 | 2021-12-21 | 公立大学法人大阪 | Chiral detection device, chiral detection method, separation device, separation method, and chiral substance device |
| CN113125547A (en) * | 2020-01-16 | 2021-07-16 | 同济大学 | Chiral compound detection method |
| CN113125548A (en) * | 2020-01-16 | 2021-07-16 | 同济大学 | Chiral compound detection system |
| CN113125547B (en) * | 2020-01-16 | 2022-04-08 | 同济大学 | Chiral compound detection method |
| CN113125548B (en) * | 2020-01-16 | 2022-04-08 | 同济大学 | Chiral compound detection system |
| CN114112926A (en) * | 2021-11-26 | 2022-03-01 | 西安邮电大学 | Carbon nanotube chiral molecule detection device |
| CN114112926B (en) * | 2021-11-26 | 2023-08-18 | 西安邮电大学 | Carbon nanotube chiral molecule detection device |
| EP4312039A1 (en) * | 2022-07-26 | 2024-01-31 | Hitachi, Ltd. | Biosensing apparatus |
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Application publication date: 20190111 |