CN109172673A - 一种用于防治伴侣动物皮肤真菌病的中药喷膜剂及其制备方法 - Google Patents
一种用于防治伴侣动物皮肤真菌病的中药喷膜剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,包括中药组和成膜组,所述中药组包主要由以下重量份的原料药材制备而成:博落回20‑50份、皂角10‑30份、黄柏10‑30份、藿香10‑30份;所述的成膜组主要由以下重量份的原料制备而成:羧甲基纤维素钠0.1‑2.0份、聚乙二醇6000 1‑15份、明胶1‑15份、蒸馏水68‑98份。本发明制得的用于防治伴侣动物皮肤真菌病的中药喷膜剂,每毫升相当于原生药0.5‑0.8克,可将药物紧贴于皮肤上,且其载药量大,外用作用于局部对皮肤无刺激,能够有效防治伴侣动物皮肤真菌病,无不良反应。
Description
技术领域
本发明涉及中药技术领域,尤其是一种用于防治伴侣动物皮肤真菌病的中药喷膜剂。
背景技术
伴侣动物是一类能够和人生活在一起,进行亲密沟通和相互情感交流,能够给人们带来生活快乐的宠物,它们大多非常驯服,活泼可爱,机灵小巧,主要有家养的犬、猫、鸟、鱼、兔、赛鸽及斗鸡等动物。伴侣动物已经被当成家庭成员一样的存在,与主人同吃、同住。可伴侣动物却因其不讲卫生的习性,常常感染人畜共患的皮肤真菌病,如犬小孢子菌、石膏样小孢子菌和须毛癣菌等,因此,防治伴侣动物的真菌病对公共卫生尤为重要。
宠物真菌感染导致的皮肤病,是一种宠物十分常见的传染性疾病。真菌皮肤病又称为皮癣,是由皮肤真菌感染造成的。宠物真菌感染的疾病是可以传染的,而且可以传染给人,因此需要提早预防,早发现、早治疗。目前,防治动物皮肤真菌病的药物以西药为主,如克霉唑、酮康唑、氟康唑等等,这些药物在临床运用广泛,但有的毒性大,且产生耐药也快。因此,开发无毒、有效的抗真菌药物制剂势在必行。
发明内容
本发明所要解决的技术问题是提供一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,该药剂无毒副作用,在防治伴侣动物皮肤真菌病时,不会产生耐药性。
本发明解决其技术问题所采用的技术方案是:一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,包括中药组和成膜组,所述中药组包主要由以下重量份的原料药材制备而成:
博落回 20-50份、
皂角 10-30份、
黄柏 10-30份、
藿香 10-30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠 0.1-2.0份、
聚乙二醇6000 1-15份、
明胶 1-15份、
蒸馏水 68-98份。
优选的,所述中药组主要由以下重量份的原料药材制备而成:
博落回 30-40份、
皂角 15-25份、
黄柏 15-25份、
藿香 15-30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠 0.5-1.5份、
聚乙二醇6000 5-10份、
明胶 5-10份、
蒸馏水 80-90份。
优选的,所述中药组主要由以下重量份的原料药材制备而成:
博落回 30份、
皂角 20份、
黄柏 20份、
藿香 30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠 0.5份、
聚乙二醇6000 5份、
明胶 5份、
蒸馏水 89.5份。
各原料药材的药理功效如下:
1、博落回:【性味归经】味苦,辛,性寒,温,大毒;【功能主治】散瘀;祛风;解毒;止痛;杀虫;主痛疮疔肿;臁疮;痔疮;湿疹;蛇虫咬伤;跌打肿痛;风湿关节痛;龋齿痛;顽癣;滴虫性阴道炎及酒糟鼻。
2、黄柏:【性味归经】苦,寒,归经归肾、膀胱经;【功能主治】清热燥湿,泻火除蒸,解毒疗疮;用于湿热泻痢,黄疸,带下,热淋,脚气,痿{辟},骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒;盐黄柏滋阴降火。用于阴虚火旺,盗汗骨蒸。
3、皂角:【性味归经】性温,味辛、咸,有小毒;归肺经、大肠经;【功效与作用】开窍祛痰、散结消肿、润燥通便;属涌吐药。
4、藿香:【性味归经】味辛,性温,归脾、胃、肺经;【功效与作用】化湿醒脾,辟秽和中,解暑,发表;用于湿阻脾胃、脘腹胀满、湿温初起、呕吐、泄泻、暑湿、发热恶寒、恶寒发热、胸脘满闷等症。
本发明中药喷膜剂中主要起抗真菌作用的博落回为君药,同样具有抗真菌作用的黄柏辅助抗真菌,为臣药,皂角和藿香作为佐药,在四味中药的协同作用下,既具有强的抗真菌作用,还兼治真菌所致的肿、疮、瘙痒等证。
一种用于防治伴侣动物皮肤真菌病的中药喷膜剂的制备方法,包括以下步骤:
中药组的制备:
(1)取配方量博落回、皂角、黄柏、藿香,加入原料药材重量3-5倍的乙醇浸泡20-40分钟后,再加入相同重量的乙醇进行提取,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量6-8倍的水,加热提取,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组;
成膜组的制备:
(2)取配方量羧甲基纤维素钠、聚乙二醇、明胶、蒸馏水,将羧甲基纤维素钠加入蒸馏水进行溶胀,得浓度为1-10‰g/ml的羧甲基纤维素钠水溶液;将聚乙二醇和明胶加入蒸馏水加热溶解得浓度为5-20%g/ml的混合水溶液;将羧甲基纤维素钠水溶液和混合水溶液混合即得成膜组;
中药喷膜剂的制备:
(3)将步骤(1)所得的中药组和步骤(2)所得的成膜组混合均匀即得用于防治伴侣动物皮肤真菌病的中药喷膜剂。
优选的,所述步骤(3)中药组和成膜组的重量比为5-8﹕2-5。
优选的,步骤(1)所述乙醇的体积浓度为75%。
优选的,步骤(1)中药组的制备方法为:取配方量博落回、皂角、黄柏、藿香,加入原料药材重量3-5倍的乙醇浸泡30分钟后,再加入原料药材重量3-5倍的乙醇,在80℃下进行回流提取1次,提取时间1.5小时,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量6-8倍的水,加热提取两次,每次提取时间为2小时,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组。
本发明的有益效果是:本发明制得的用于防治伴侣动物皮肤真菌病的中药喷膜剂,每毫升相当于原生药0.5-0.8克,可将药物紧贴于皮肤上,且其载药量大,外用作用于局部对皮肤无刺激,能够有效防治伴侣动物皮肤真菌病,还兼治真菌所致的肿、疮、瘙痒等证,无不良反应。
具体实施方式
下面结合实施例对本发明进一步说明。
实施例1:
原料药材组成:博落回30份、皂角20份、黄柏20份、藿香30份。
成膜组的组成:羧甲基纤维素钠0.5份、聚乙二醇6000 5份、明胶5份、蒸馏水89.5份。
制备方法:
中药组的制备:
(1)按重量比取配方量博落回、皂角、黄柏、藿香,加入原料药材重量4倍的乙醇浸泡30分钟后,再加入料药材重量4倍的乙醇进行提取,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量7倍的水,加热提取,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组;
成膜组的制备:
(2)按重量比取配方量羧甲基纤维素钠、聚乙二醇、明胶、蒸馏水,将羧甲基纤维素钠加入蒸馏水进行溶胀,得浓度为1-10‰g/ml的羧甲基纤维素钠水溶液;将聚乙二醇和明胶加入蒸馏水加热溶解得浓度为5-20%g/ml的混合水溶液;将羧甲基纤维素钠水溶液和混合水溶液混合即得成膜组;
中药喷膜剂的制备:
(3)将步骤(1)所得的中药组和步骤(2)所得的成膜组混合均匀即得用于防治伴侣动物皮肤真菌病的中药喷膜剂。
实施例2:
原料药材组成:博落回20份、皂角30份、黄柏30份、藿香20份。
成膜组的组成:羧甲基纤维素钠0.3份、聚乙二醇6000 10份、明胶3份、蒸馏水86.7份。
制备方法:
中药组的制备:
(1)按重量比取配方量博落回、皂角、黄柏、藿香,加入原料药材重量4倍的乙醇浸泡30分钟后,再加入料药材重量4倍的乙醇进行提取,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量7倍的水,加热提取,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组;
成膜组的制备:
(2)按重量比取配方量羧甲基纤维素钠、聚乙二醇、明胶、蒸馏水,将羧甲基纤维素钠加入蒸馏水进行溶胀,得浓度为1-10‰g/ml的羧甲基纤维素钠水溶液;将聚乙二醇和明胶加入蒸馏水加热溶解得浓度为5-20%g/ml的混合水溶液;将羧甲基纤维素钠水溶液和混合水溶液混合即得成膜组;
中药喷膜剂的制备:
(3)将步骤(1)所得的中药组和步骤(2)所得的成膜组混合均匀即得用于防治伴侣动物皮肤真菌病的中药喷膜剂。
实施例3:
原料药材组成:博落回40份、皂角20份、黄柏20份、藿香20份。
成膜组的组成:羧甲基纤维素钠0.6份、聚乙二醇6000 8份、明胶5份、蒸馏水86.4份。
制备方法:
中药组的制备:
(1)按重量比取配方量博落回、皂角、黄柏、藿香,加入原料药材重量4倍的乙醇浸泡30分钟后,再加入料药材重量4倍的乙醇进行提取,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量7倍的水,加热提取,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组;
成膜组的制备:
(2)按重量比取配方量羧甲基纤维素钠、聚乙二醇、明胶、蒸馏水,将羧甲基纤维素钠加入蒸馏水进行溶胀,得浓度为1-10‰g/ml的羧甲基纤维素钠水溶液;将聚乙二醇和明胶加入蒸馏水加热溶解得浓度为5-20%g/ml的混合水溶液;将羧甲基纤维素钠水溶液和混合水溶液混合即得成膜组;
中药喷膜剂的制备:
(3)将步骤(1)所得的中药组和步骤(2)所得的成膜组混合均匀即得用于防治伴侣动物皮肤真菌病的中药喷膜剂,其中每毫升中药喷膜剂相当于原生药0.8克。
实验数据:
取博落回、皂角、黄柏、藿香分别按照本发明中药喷膜剂的制备方法制备成喷膜剂,同时取抗真菌药物酮康唑来与实施例3的中药喷膜剂来对照试验,采用药基混合(药物与培养基)的方法,测定MIC值。结果如下表所示:
药物 | 犬小孢子菌 | 石膏样小孢子菌 | 须毛癣菌 |
酮康唑(μg/mL) | 0.5 | 0.25 | 0.25 |
博落回喷膜剂(mg/mL) | 2.5 | 2.5 | 2.5 |
黄柏喷膜剂(mg/mL) | 1.25 | 1.25 | 0.625 |
皂角喷膜剂(mg/mL) | 1.25 | 1.25 | 2.5 |
藿香喷膜剂(mg/mL) | 5.0 | 5.0 | 1.25 |
中药喷膜剂(mg/mL) | 0.031 | 0.625 | 0.625 |
伴侣动物皮肤真菌病,在中兽医学上属“癣”“疮”等的范畴,认为其病因多是湿热蕴蒸,湿热下注,虫毒侵袭。可以看出,黄柏喷膜剂对须毛癣菌具有明显的效果,藿香喷膜剂的抗皮肤真菌的作用不明显,而本发明博落回、黄柏、皂角、藿香几味中药制成的中药喷膜剂具有较强的抗皮肤真菌的作用,尤其是对犬小孢子菌的MIC值远小于酮康唑的MIC值。
临床实验数据:
1、治疗皮肤真菌病效果观察
选择皮肤真菌病的猫31只,犬35只,连续治疗3个疗程观察疗效。
2、分组及治疗方法:
将两种宠物随机分为两组,1组为10只猫,17只犬,采用酮康唑软膏治疗,每天涂抹患处1次,3次为一疗程,连续治疗3个疗程;2组为11只猫,18只犬,采用实施例3的中药喷膜剂喷洒患处,3次为一疗程,连续治疗3个疗程。
3、疗效判定标准
(1)治愈:皮肤表皮、被毛恢复正常,瘙痒症状消失,精神正常,停药后一周后不复发。
(2)有效:皮肤表皮、被毛恢复正常,瘙痒症状好转,精神正常,但停药后一周后复发。
(3)无效:以上症状和精神无任何改善。
观察两个实验组宠物的治疗情况,结果如下表所示:
4、结果
由上表可以看出,在治疗过程中,使用本发明组合物治疗34例病症不同的患者,结果治愈31例,有效32例,无效2例,总有效率94.12%,治愈率为91.18%,其有效率和治愈率均高于酮康唑软膏组。在使用过程中,所有患者均未出现过敏或毒副等不良反应。因此本中药喷膜剂可用于防治宠物皮肤真菌病,且临床使用方便,治愈率高,复发率低,且毒副作用小,值得推广。
Claims (7)
1.一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,其特征在于:包括中药组和成膜组,所述中药组包主要由以下重量份的原料药材制备而成:
博落回20-50份、
皂角10-30份、
黄柏10-30份、
藿香10-30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠0.1-2.0份、
聚乙二醇6000 1-15份、
明胶1-15份、
蒸馏水68-98份。
2.根据权利要求1所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,其特征在于:所述中药组主要由以下重量份的原料药材制备而成:
博落回30-40份、
皂角15-25份、
黄柏15-25份、
藿香15-30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠0.5-1.5份、
聚乙二醇6000 5-10份、
明胶5-10份、
蒸馏水80-90份。
3.根据权利要求2所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂,其特征在于:所述中药组主要由以下重量份的原料药材制备而成:
博落回30份、
皂角20份、
黄柏20份、
藿香30份;
所述的成膜组主要由以下重量份的原料制备而成:
羧甲基纤维素钠0.5份、
聚乙二醇6000 5份、
明胶5份、
蒸馏水89.5份。
4.根据权利要求1-3任一项所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂的制备方法,其特征在于,包括以下步骤:
中药组的制备:
(1)取配方量博落回、皂角、黄柏、藿香,加入原料药材重量3-5倍的乙醇浸泡20-40分钟后,再加入相同重量的乙醇进行提取,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量6-8倍的水,加热提取,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组;
成膜组的制备:
(2)取配方量羧甲基纤维素钠、聚乙二醇、明胶、蒸馏水,将羧甲基纤维素钠加入蒸馏水进行溶胀,得浓度为1-10‰g/ml的羧甲基纤维素钠水溶液;将聚乙二醇和明胶加入蒸馏水加热溶解得浓度为5-20%g/ml的混合水溶液;将羧甲基纤维素钠水溶液和混合水溶液混合即得成膜组;
中药喷膜剂的制备:
(3)将步骤(1)所得的中药组和步骤(2)所得的成膜组混合均匀即得用于防治伴侣动物皮肤真菌病的中药喷膜剂。
5.根据权利要求4所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂的制备方法,其特征在于,所述步骤(3)中药组和成膜组的重量比为5-8﹕2-5。
6.根据权利要求4所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂的制备方法,其特征在于,步骤(1)所述乙醇的体积浓度为75%。
7.根据权利要求4所述的一种用于防治伴侣动物皮肤真菌病的中药喷膜剂的制备方法,其特征在于,步骤(1)中药组的制备方法为:取配方量博落回、皂角、黄柏、藿香,加入原料药材重量3-5倍的乙醇浸泡30分钟后,再加入原料药材重量3-5倍的乙醇,在80℃下进行回流提取1次,提取时间1.5小时,将所得醇提取液浓缩至原料药材重量的1/2,得醇提液;向提取后的滤渣中加入滤渣重量6-8倍的水,加热提取两次,每次提取时间为2小时,收集滤液并浓缩至原料药材重量的1/2,得水提液;将所得的醇提液和所得的水提液混合均匀,得中药组。
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