CN109157681A - A kind of preparation method of medical use anti-infection conduit - Google Patents
A kind of preparation method of medical use anti-infection conduit Download PDFInfo
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- CN109157681A CN109157681A CN201810942044.4A CN201810942044A CN109157681A CN 109157681 A CN109157681 A CN 109157681A CN 201810942044 A CN201810942044 A CN 201810942044A CN 109157681 A CN109157681 A CN 109157681A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/02—Inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/043—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The invention discloses a kind of preparation method of medical use anti-infection conduit, the technique by the raw material such as polyvinyl chloride, polyurethane, polystyrene, silica, glass fibre carry out after heating reaction, pressurization defoaming treatment by mold disseminate in the way of carry out conduit casting, Treatment with activating agent, liquid nitrogen cooling and solidifying, ultrasonic cleaning and etc. activator component and antibacterial agent ingredient are bonded to wall surface inside and outside conduit in the way of sonification medium obtain medical use anti-infection conduit.The medical use anti-infection conduit being prepared, anti-pressure ability is strong, elasticity is good, stretch capability is good while having the performance of antibacterial anti-infection, can satisfy a variety of demands of medical industry.
Description
Technical field
The present invention relates to this technical fields of medical catheter material, are related specifically to a kind of preparation of medical use anti-infection conduit
Method.
Background technique
With the development of conduit Clinics, medical catheter reaches its maturity in clinical application, and conduit industry becomes medical treatment
One important class of instrument.Only the conduit of urological applications of compounds just has more than 6 major class 120 in the world at present, for it is cardiovascular,
The conduit of the diagnosis of disease such as the cerebrovascular, tumour also has more than 100.With the development of science and technology, medical technique level is continuously improved, face
Bed constantly puts forward higher requirements conduit, and conduit industry need to constantly bring forth new ideas to meet clinical needs.With increased population and
Aging development, medical catheter are increasing in clinical application.Medical polyurethane is the common material of interposing catheter, interposers
Tool requires the surface with lubricity when entering or extracting human body and move in human body, to avoid internal group of damage
It knits.Medical polyurethane conduit itself is hydrophobic material, and surface does not have lubricity, although can using lubricant or gel coat
To obtain temporary lubricity, but lasting lubricity is only obtained by modified material itself or material surface.Surface
Modified method can make material keep possessed physical and mechanical property itself and material surface is made to have necessary table
Face performance；In addition, medical polyurethane conduit is usually applied to the environment contacted with body fluid (water), and in water environment, it is high hydrophilic
Material can more reduce absorption of the surface to cell and protein etc. than high hydrophobic material.This requires research staff according to above right
A kind of medical polyurethane modified material that can satisfy medical applications is developed in the requirement of medical polyurethane.
Summary of the invention
In order to solve the above-mentioned technical problem, the invention discloses a kind of preparation method of medical use anti-infection conduit, the techniques
The raw material such as polyvinyl chloride, polyurethane, polystyrene, silica, glass fibre are subjected to heating reaction, pressurization defoaming treatment
Afterwards by mold dip dyeing in the way of carry out conduit casting, Treatment with activating agent, liquid nitrogen cooling and solidifying, ultrasonic cleaning and etc. will activation
Agent ingredient and antibacterial agent ingredient are bonded to wall surface inside and outside conduit by way of sonification medium and obtain medical use anti-infection conduit.System
Medical use anti-infection conduit made of standby, anti-pressure ability is strong, elasticity is good, stretch capability is good while having the property of antibacterial anti-infection
Can, it can satisfy a variety of demands of medical industry.
Technical solution: to solve the above-mentioned problems, the invention discloses a kind of preparation method of medical use anti-infection conduit, packets
Include following steps:
(1) by 2-4 parts of polyethylene glycol, 2-5 parts of mannitol, 3-8 parts of sodium alginate, 1-5 parts of sodium chloride, 1-3 parts of sodium bicarbonate, super
It 50 parts of pure water, is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 10-15 parts of polyvinyl chloride, 5-9 parts of polyurethane, 2-5 parts of polystyrene, -3 parts of silica 1, glass fibre 1-2
Part is uniform in mixed at room temperature, is added into reacting furnace, is then heated to 80-85 DEG C, persistently stirs 30-60 minutes, then cools down
To 40-42 DEG C, defoaming agent is added, compressive reaction 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) conduit casting die is successively used into 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 2-5 hours in freezing chamber after conduit demoulding；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) is cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, drying is packed to get finished product.
Preferably, defoaming agent is polynary selected from dimethyl silicone polymer, polyoxypropylene, polyoxyethylene, siloxanes in the step (2)
One or more of alcohol.
Preferably, pressure is 5-10MPa in the step (2).
Preferably, the freezer temperature in the step (6) is -15~-20 DEG C.
Preferably, the buffer formulation of the antimicrobial component in the step (8) are as follows: Tris-HCl buffer 1000ml, poly- silicon oxygen
Alkane quaternary ammonium salt antiseptic 0.5%, methyl-silicone oil 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine
0.05%, glycine 0.2%, proline 0.03%, glycerol 3%.
Preferably, the drying temperature in the step (9) is 65 DEG C.
Compared with prior art, the present invention has the advantages that:
(1) preparation method of medical use anti-infection conduit of the invention is by polyvinyl chloride, polyurethane, polystyrene, silica, glass
The raw material such as glass fiber carry out conduit casting, activation after carrying out heating reaction, pressurization defoaming treatment in the way of mold dip dyeing
Agent processing, liquid nitrogen cooling and solidifying, ultrasonic cleaning and etc. by activator component and antibacterial agent ingredient by way of sonification medium
It is bonded to wall surface inside and outside conduit and obtains medical use anti-infection conduit.The medical use anti-infection conduit being prepared, anti-pressure ability is strong,
Elasticity is good, stretch capability is good while having the performance of antibacterial anti-infection, can satisfy a variety of demands of medical industry.
(2) medical use anti-infection conduit raw material of the invention be easy to get, simple process, be suitable for heavy industrialization use, it is practical.
Specific embodiment
Embodiment 1
(1) by 2 parts of polyethylene glycol, 2 parts of mannitol, 3 parts of sodium alginate, 1 part of sodium chloride, 1 part of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 10 parts of polyvinyl chloride, 5 parts of polyurethane, 2 parts of polystyrene, silica 1 part, 1 part of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 30 minutes, be then cooled to 40-42 DEG C, be added poly-
Dimethyl siloxane is forced into 5MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) conduit casting die is successively used into 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 2 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) being cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component, wherein
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, 65 DEG C of drying are packed to get finished product.
Embodiment 2
(1) by 3 parts of polyethylene glycol, 3 parts of mannitol, 4 parts of sodium alginate, 2 parts of sodium chloride, 2 parts of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 12 parts of polyvinyl chloride, 6 parts of polyurethane, 3 parts of polystyrene, 2 parts of silica, 1 part of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 40 minutes, be then cooled to 40-42 DEG C, be added poly-
Oxypropylene is forced into 6MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；(3) by conduit
Casting die successively uses 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 3 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) being cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component, wherein
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, 65 DEG C of drying are packed to get finished product.
Embodiment 3
(1) by 3 parts of polyethylene glycol, 4 parts of mannitol, 7 parts of sodium alginate, 4 parts of sodium chloride, 2 parts of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 14 parts of polyvinyl chloride, 8 parts of polyurethane, 4 parts of polystyrene, 2 parts of silica, 2 parts of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 50 minutes, be then cooled to 40-42 DEG C, be added poly-
Ethylene oxide is forced into 8MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；(3) by conduit
Casting die successively uses 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 4 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) being cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component, wherein
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, 65 DEG C of drying are packed to get finished product.
Embodiment 4
(1) by 4 parts of polyethylene glycol, 5 parts of mannitol, 8 parts of sodium alginate, 5 parts of sodium chloride, 3 parts of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 15 parts of polyvinyl chloride, 9 parts of polyurethane, 5 parts of polystyrene, 3 parts of silica, 2 parts of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 60 minutes, be then cooled to 40-42 DEG C, silicon is added
Oxygen alkane polyalcohol is forced into 10MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) conduit casting die is successively used into 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 5 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) being cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component, wherein
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, 65 DEG C of drying are packed to get finished product.
Comparative example 1
(1) by 2 parts of polyethylene glycol, 2 parts of mannitol, 3 parts of sodium alginate, 1 part of sodium chloride, 1 part of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 10 parts of polyvinyl chloride, 5 parts of polyurethane, 2 parts of polystyrene, silica 1 part, 1 part of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 30 minutes, be then cooled to 40-42 DEG C, be added poly-
Dimethyl siloxane is forced into 5MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) conduit casting die is successively used into 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 2 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) high pressure sterilization is carried out to the catheter-based ultrasound after step (7) ultrasound, 65 DEG C of drying are packed to get finished product.
Comparative example 2
(1) by 4 parts of polyethylene glycol, 5 parts of mannitol, 8 parts of sodium alginate, 5 parts of sodium chloride, 3 parts of sodium bicarbonate, 50 parts of ultrapure water,
It is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 15 parts of polyvinyl chloride, 9 parts of polyurethane, 5 parts of polystyrene, 3 parts of silica, 2 parts of glass fibre in mixed at room temperature
Uniformly, it is added into reacting furnace, is then heated to 80-85 DEG C, persistently stir 60 minutes, be then cooled to 40-42 DEG C, silicon is added
Oxygen alkane polyalcohol is forced into 10MPa and reacts 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) the conduit casting die of the drying of step (2) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(4) the conduit casting die that step (3) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(5) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (4), is allowed to cool, solidifies, demoulds,
Continue to solidify 5 hours in freezing chamber after conduit demoulding, freezer temperature is -15~-20 DEG C；
(6) conduit in step (5) is subjected to ultrapure water, naturally dry；
(7) conduit of step (6) being cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component, wherein
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%；
(8) high pressure sterilization is carried out to the catheter-based ultrasound after step (7) ultrasound, 65 DEG C of drying are packed to get finished product.
By the medical use anti-infection conduit obtained of embodiment 1-4 and comparative example 1-2 respectively according to country or professional standard into
Action coefficient of friction, contact angle, elongation at break, Escherichia coli bacteriostasis rate, staphylococcus aureus bacteriostasis rate, Candida albicans
This several performance tests of bacteriostasis rate, test result are shown in Table 1.
Table 1
The preparation method of medical use anti-infection conduit of the invention by polyvinyl chloride, polyurethane, polystyrene, silica,
The raw material such as glass fibre carry out conduit casting, work in the way of mold dip dyeing after carrying out heating reaction, pressurization defoaming treatment
Agent processing, liquid nitrogen cooling and solidifying, ultrasonic cleaning and etc. the side that activator component and antibacterial agent ingredient are passed through into sonification medium
Formula is bonded to wall surface inside and outside conduit and obtains medical use anti-infection conduit.The medical use anti-infection conduit being prepared, anti-pressure ability
By force, elasticity is good, stretch capability is good while having the performance of antibacterial anti-infection, can satisfy a variety of demands of medical industry.This hair
Bright medical use anti-infection conduit raw material is easy to get, simple process, is suitable for heavy industrialization and uses, practical.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (6)
1. a kind of preparation method of medical use anti-infection conduit, which comprises the following steps:
(1) by 2-4 parts of polyethylene glycol, 2-5 parts of mannitol, 3-8 parts of sodium alginate, 1-5 parts of sodium chloride, 1-3 parts of sodium bicarbonate, super
It 50 parts of pure water, is uniformly mixed and carries out magnetic agitation 15 minutes, by mixed liquor in being stored at room temperature 2 hours, it is spare to obtain activator；
(2) by 10-15 parts of polyvinyl chloride, 5-9 parts of polyurethane, 2-5 parts of polystyrene, -3 parts of silica 1, glass fibre 1-2
Part is uniform in mixed at room temperature, is added into reacting furnace, is then heated to 80-85 DEG C, persistently stirs 30-60 minutes, then cools down
To 40-42 DEG C, defoaming agent is added, compressive reaction 25-30 minutes, replys pressure to normal pressure, obtains material stoste, keep the temperature spare；
(3) conduit casting die is successively used into 65 DEG C of drying after sodium citrate solution and ultrapure water；
(4) the conduit casting die of the drying of step (3) is infiltrated in the activator of step (1), makes conduit casting die table
Layer dip dyeing activator, infiltrating time are 30-40 seconds；
(5) the conduit casting die that step (4) has infiltrated activator is infiltrated and carries out conduit casting in the material stoste of step (2)
Part took out mold after 60-90 seconds；
(6) it is sprayed liquid nitrogen about 5-10 seconds in freezing chamber to the conduit casting die of step (5), is allowed to cool, solidifies, demoulds,
Continue to solidify 2-5 hours in freezing chamber after conduit demoulding；
(7) conduit in step (6) is subjected to ultrapure water, naturally dry；
(8) conduit of step (7) is cleaned by ultrasonic, ultrasonic cleaning medium uses the buffer with antimicrobial component；
(9) high pressure sterilization is carried out to the catheter-based ultrasound after step (8) ultrasound, drying is packed to get finished product.
2. the preparation method of medical use anti-infection conduit according to claim 1, which is characterized in that disappear in the step (2)
Infusion is selected from one or more of dimethyl silicone polymer, polyoxypropylene, polyoxyethylene, siloxane polyol.
3. the preparation method of medical use anti-infection conduit according to claim 1, which is characterized in that pressure in the step (2)
It is by force 5-10MPa.
4. the preparation method of medical use anti-infection conduit according to claim 1, which is characterized in that in the step (6)
Freezer temperature is -15~-20 DEG C.
5. the preparation method of medical use anti-infection conduit according to claim 1, which is characterized in that in the step (8)
The buffer formulation of antimicrobial component are as follows: Tris-HCl buffer 1000ml, polysiloxane quaternary ammonium antibacterial agent 0.5%, methyl silicon
Oily 0.1%, sodium citrate 0.6%, ethambutol 0.02%, sulfamethazine 0.05%, glycine 0.2%, proline
0.03%, glycerol 3%.
6. the preparation method of medical use anti-infection conduit according to claim 1, which is characterized in that in the step (9)
Drying temperature is 65 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810942044.4A CN109157681A (en) | 2018-08-17 | 2018-08-17 | A kind of preparation method of medical use anti-infection conduit |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113797425A (en) * | 2021-11-01 | 2021-12-17 | 深圳麦普奇医疗科技有限公司 | Manufacturing method of thrombolytic catheter plugging guide wire |
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