CN109125257A - Ammonia phenol more creates feritin oral solution and preparation method thereof - Google Patents
Ammonia phenol more creates feritin oral solution and preparation method thereof Download PDFInfo
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- CN109125257A CN109125257A CN201811213974.2A CN201811213974A CN109125257A CN 109125257 A CN109125257 A CN 109125257A CN 201811213974 A CN201811213974 A CN 201811213974A CN 109125257 A CN109125257 A CN 109125257A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Abstract
Ammonia phenol of the present invention more creates feritin oral solution and preparation method thereof, the purpose is to provide it is a kind of can alleviate or treat nasal obstruction caused by flu and influenza, have a headache and slight pain, congestion of nasal sinus and pressure, bring down a fever, it is sensible, improve nasal airflow, the ammonia phenol of nasal sinus drainage, resolving sputum, antitussive effect is promoted more to create feritin oral solution, the oral solution is suitable for 12 years old or more crowd and takes, with fruity, it is easy to take.The preparation method for creating feritin oral solution is cured it is a further object to provide ammonia phenol, this method is easy to operate, and pollution-free, production cost is low, is suitable for industrialization production.
Description
Technical field
The invention belongs to medicament research and development technical fields, and in particular to ammonia phenol more creates feritin oral solution and preparation method thereof.
Background technique
Caused by flu mainly weakens due to physically weak and anti-virus ability, it is mainly shown as nasal obstruction, sneezing, stream nose
The symptoms such as tears, cough, expectoration, headache, anorexia or fever.
Influenza (abbreviation influenza) be acute respiratory infection caused by influenza virus and a kind of infectiousness it is strong,
The fast disease of spread speed.Its main through the air droplet, interpersonal contact or with the contact of contaminated article
It propagates.
The drug for the treatment of flu has much now, is mostly oral drugs, in the majority with electuary, tablets and capsules, still
Existing most of cold drugs, all not to the limitation on the age, cause disorderly to take cold drug phenomenon, especially much on usage and dosage
Parent halves adult cold's medicine to take to child, can thus impair children's health.Taking dose is excessive, nothing takes the age
Limitation, specification is uneven and medication mouthfeel is bad, is the existing extremely serious problem of China's cold drug.
Summary of the invention
The object of the present invention is to provide one kind can alleviate or treat caused by flu and influenza nasal obstruction, has a headache and slight
Pain, congestion of nasal sinus and pressure bring down a fever, are sensible, improving nasal airflow, and the ammonia phenol of nasal sinus drainage, resolving sputum, antitussive effect is promoted to be cured
Feritin oral solution is created, which is suitable for 12 years old or more crowd and takes, and has fruity, is easy to take.
The preparation method for creating feritin oral solution is cured it is a further object to provide ammonia phenol, this method is easy to operate,
Pollution-free, production cost is low, is suitable for industrialization production.
Technical scheme is as follows:
Prescription:
(1) contain in every 1000ml:
Paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, xanthan gum 5-
2.0g, propylene glycol 100.0-500.0g, glycerol 100.0-300.0g, propylgallate 0.5-5.0g, natrium adetate 0.1-
1.0g, anhydrous citric acid 0.5-3.0g, sodium benzoate 1.0-4.0g, sorbierite 50.0-200.0-5.0g, Sucralose 0.5-
5.0g, trisodium citrate 0.5-3.0g, pigment 10.0-30.0mg, essence 0.5-5.0ml.Purified Water q. s.
(2) it is also possible that 32.5g containing paracetamol, guaiacol glycerol ether 20.0g, hydrochloric acid are gone in every 1000ml
Oxygen adrenaline 0.5g, xanthan gum 0.95g, propylene glycol 300.0g, glycerol 200.0g, propylgallate 2.0g, edetic acid(EDTA) two
Sodium 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.0g, sorbierite 100.0g, Sucralose 2.5g, trisodium citrate 1.0g,
Pigment 28.5mg, essence 2.5ml.Purified Water q. s.
(3) preferably, 32.5g containing paracetamol, guaiacol glycerol ether 20.0g, hydrochloric acid deoxidation in every 1000ml
Adrenaline 0.5g, xanthan gum 1.0g, propylene glycol 250.0g, glycerol 200g, propylgallate 2.0g, natrium adetate
0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, Sucralose 2.5g, trisodium citrate 2.2g, pigment
2.0mg, essence 2.5ml.Purified Water q. s.
(4) 32.5g containing paracetamol in every 1000ml, guaiacol glycerol ether 20.0g, hydrochloric acid deoxidation be can also be
Adrenaline 0.5g, xanthan gum 0.95g, propylene glycol 300g, glycerol 200g, propylgallate 2.0g, natrium adetate 0.5g,
Anhydrous citric acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, Sucralose 0.73g, trisodium citrate 2.2g, pigment
28.5mg, essence 2.5ml.Purified Water q. s.
Preparation method
Preparation method 1: can take above-mentioned (1)-(4) any prescription,
1, recipe quantity xanthan gum, propylene glycol are weighed into clean container, stirring is allowed to be uniformly dispersed, and obtains medical fluid 1, standby
With；
2, propylgallate, natrium adetate, anhydrous citric acid, sodium benzoate, the sorbierite, lemon of recipe quantity are weighed
Sour trisodium, Sucralose are set in clean container, are stirred to dissolve or evenly dispersed, are added in above-mentioned medical fluid 1, are continued to stir, make
Dissolution or be uniformly dispersed, obtain medical fluid 2, it is spare；
3, the glycerol for weighing recipe quantity is added in above-mentioned medical fluid 2 after adding a small amount of water to dilute, under stirring, successively plus
Enter the paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE of recipe quantity, stirring makes after all dissolving, successively
Be added recipe quantity pigment, essence, add water to amount of preparation, stir evenly, filter, degassing, dress to get.
Preparation method 2: can take above-mentioned (1)-(4) any prescription,
1, the xanthan gum of recipe quantity is weighed in clean container, a certain amount of water is added and is allowed to be swollen, and static 12-15h is obtained
Medical fluid 1, it is spare；
2, glycerol, the propylene glycol for weighing recipe quantity are added in above-mentioned medical fluid 1, and stirring is allowed to dissolve or disperse, and obtain medical fluid 2,
It is spare；
3, recipe quantity paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE, gallic acid third are separately weighed
Above-mentioned medical fluid 2 is added in ester, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite, trisodium citrate and Sucralose
In, stirring makes it dissolve, and in pigment, the essence for sequentially adding recipe quantity, adds water to amount of preparation, stirring dissolves it all, mistake
Filter, degassing, it is filling to get.
Preparation method 3: can take above-mentioned (1)-(4) any prescription,
1, paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE, the gallic acid third of recipe quantity are weighed
Ester, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite, trisodium citrate and Sucralose are in Agitation Tank, mixing
Uniformly, medicinal mixture is obtained, it is spare；
2, recipe quantity glycerol, propylene glycol are weighed, after the dilution of a small amount of water, is added in said medicine mixture, stirring makes it
Dissolution, is added pigment, the essence of recipe quantity, adds water to amount of preparation, after stirring dissolves it all, filters, and degassing is filling, i.e.,
?.
Preparation method 4: can take above-mentioned (1)-(4) any prescription,
1, it weighs recipe quantity xanthan gum to be added in the propylene glycol of recipe quantity, after stirring to dissolve or dispersing, prescription is added
The glycerol of amount continues to stir to dissolve, and obtains medical fluid 1, spare；
2, paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE are sequentially added in medical fluid 1, stirring makes
Medical fluid 2 is dissolved to obtain, it is spare；
3, propylgallate, natrium adetate, anhydrous citric acid, sodium benzoate, the sorb of recipe quantity are separately weighed respectively
Alcohol, trisodium citrate and Sucralose, it is 50-75 DEG C of water that a small amount of temperature, which is added, and after stirring to dissolve, above-mentioned medical fluid 2 is added
In, in pigment, the essence for sequentially adding recipe quantity, amount of preparation is added water to, is stirred, after dissolving it all, filters, deaerates, fill
Dress to get.
The essence refers to one or more kinds of mixed of flavoring pineapple essence or flavoring apple essence or orange essence or hawthorn essence
Close object；
The pigment refers to that brilliant blue or temptation are red one such.
The filtering refers to 0.35-0.60um filtering with microporous membrane；
The degassing refers to medical fluid decompression method degassing 10-60min.
The present invention have alleviate or treatment flu and influenza caused by nasal obstruction, headache and slight pain, congestion of nasal sinus and
The effects of pressure brings down a fever, is sensible, improvement nasal airflow, promoting nasal sinus drainage, resolving sputum, antibechic.
The present invention is suitable for 12 years old or more crowd and takes, fruity.
Beneficial effect
Ammonia phenol of the present invention more creates feritin oral solution and preparation method thereof, and flu and influenza can be alleviated or treat by providing one kind
Caused nasal obstruction, headache and slight pain, congestion of nasal sinus and pressure bring down a fever, are sensible, improving nasal airflow, and nasal sinus is promoted to draw
Stream, resolving sputum, antitussive medicine, the invention are suitable for 12 years old or more crowd and take, and fruity is easy to take.
The preparation method for creating feritin oral solution, this method operation letter are cured it is a further object to provide a kind of ammonia phenol
Single, pollution-free, production cost is low, is suitable for industrialization production.
Specific embodiment
Embodiment 1 (is prepared) by 1000ml amount of preparation
1, weigh xanthan gum 0.5g, propylene glycol 100g is set in clean container, stirring is allowed to be uniformly dispersed, and obtains medical fluid 1, standby
With；
2, propylgallate 0.5g, natrium adetate 0.1g, anhydrous citric acid 0.5g, sodium benzoate 1.0g, mountain are weighed
Pears alcohol 50.0g, trisodium citrate 0.5g, Sucralose 0.5 are set in clean container, are stirred to dissolve or evenly dispersed, in addition
It states in medical fluid 1, continues to stir, be allowed to dissolve or be uniformly dispersed, obtain medical fluid 2, it is spare；
3, glycerol 100g is weighed, after adding a small amount of water to dilute, is added in above-mentioned medical fluid 2, under stirring, sequentially adds place
Paracetamol 32.5g, guaiacol glycerol ether 20.0g, the PHENYLEPHRINE HYDROCHLORIDE 0.5g just measured, stirring make all molten
Xie Hou is sequentially adding brilliant blue 10mg, flavoring pineapple essence 0.5ml, is adding water to 1000ml, stir evenly, with 0.35um miillpore filter
Filtration Filtration, decompression degassing 50min, it is filling to get.
Embodiment 2 (is prepared) by 1000ml amount of preparation
1, xanthan gum 0.95g is weighed, propylene glycol 300.0g is set in clean container, and stirring is allowed to be uniformly dispersed, and obtains medical fluid
1, it is spare；
2, propylgallate 2.0g, natrium adetate 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.0g, mountain are weighed
Pears alcohol 100.0g, trisodium citrate 1.0g and Sucralose 2.5g are set in clean container, are stirred to dissolve or evenly dispersed, are added
In above-mentioned medical fluid 1, continue to stir, be allowed to dissolve or be uniformly dispersed, obtains medical fluid 2, it is spare；
3, glycerol 200.0g is weighed, after adding a small amount of water to dilute, is added in above-mentioned medical fluid 2, under stirring, sequentially adds
Paracetamol 32.5g, guaiacol glycerol ether 20.0g, the PHENYLEPHRINE HYDROCHLORIDE 0.5g of recipe quantity, stirring make whole
In brilliant blue 28.5mg, the flavoring apple essence 2.5ml for sequentially adding recipe quantity after dissolution, amount of preparation is added water to, is stirred evenly, used
0.45um filtering with microporous membrane, decompression degassing 30min, it is filling to get.
Embodiment 3 (is prepared) by 1000ml amount of preparation
1, xanthan gum 1.0g is weighed in Agitation Tank, and a certain amount of water is added and is allowed to be swollen, static 12-15h obtains medical fluid 1,
It is spare；
2, glycerol 200g, propylene glycol 250g are weighed, is added in above-mentioned medical fluid 1, stirring is allowed to dissolve or disperse, medical fluid 2 is obtained,
It is spare；
3, it separately weighs paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, have
Propyl galate 2.0g, natrium adetate 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, citric acid three
Sodium 2.2g and Sucralose 2.5g is added in above-mentioned medical fluid 2, and stirring makes it dissolve, and is sequentially adding the red 2.0mg of temptation, orange
Essence 2.5ml adds water to amount of preparation, and stirring dissolves it all, and with 0.45um filtering with microporous membrane, decompression degassing 60min is filled
Dress to get.
Embodiment 4 (is prepared) by 1000ml amount of preparation
1, it weighs paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, eat
Sub- propyl propionate 2.0g, natrium adetate 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, trisodium citrate
2.2g and Sucralose 0.73g are uniformly mixed in Agitation Tank, obtain medicinal mixture, spare；
2, glycerol 200g, propylene glycol 300g are weighed, after the dilution of a small amount of water, is added in said medicine mixture, stirring makes
It is dissolved, and brilliant blue 28.5mg, flavoring pineapple essence 2.5ml is added, and is added water to amount of preparation and is used 0.56um after stirring dissolves it all
Filtering with microporous membrane, decompression degassing 40min, it is filling to get.
Embodiment 5 (is prepared) by 1000ml amount of preparation
1, xanthan gum 0.95g, propylene glycol 300g are weighed into clean container, stirring is allowed to be uniformly dispersed, medical fluid 1 is obtained,
It is spare；
2, propylgallate 2.0g, natrium adetate 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.3g, mountain are weighed
Pears alcohol 100g, trisodium citrate 2.2g and Sucralose 0.73g are set in clean container, after being stirred to dissolve or being evenly dispersed, are added
Enter in above-mentioned medical fluid 1, continue to stir, be allowed to dissolve or be uniformly dispersed, obtains medical fluid 2, it is spare；
3, glycerol 200g is weighed, after adding a small amount of water to dilute, is added in above-mentioned medical fluid 2, under stirring, is sequentially added pair
Paracetamol 32.5g, guaiacol glycerol ether 20g, PHENYLEPHRINE HYDROCHLORIDE 0.5, stirring make after all dissolving successively
Brilliant blue 28.5mg, flavoring apple essence 2.0ml is added, adds water to amount of preparation, stirs evenly, with 0.45um filtering with microporous membrane, decompression
Deaerate 20min, it is filling to get.
Embodiment 6 (is prepared) by 1000ml amount of preparation
Contain in every 1000ml:
1, it weighs paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, eat
Sub- propyl propionate 5.0g, natrium adetate 1.0g, anhydrous citric acid 3.0g, sodium benzoate 4.0g, sorbierite 100.0g, citric acid three
Sodium 3.0g and Sucralose 5.0g are uniformly mixed in clean container, obtain medicinal mixture, spare；
2, glycerol 300.0g, propylene glycol 200g are weighed, after the dilution of a small amount of water, is added in said medicine mixture, stirring,
It makes it dissolve, brilliant blue 30mg, the orange essence 5.0ml of recipe quantity is added, add water to amount of preparation, after stirring dissolves it all,
With 0.45um filtering with microporous membrane, decompression degassing 30min, it is filling to get.
Embodiment 7 (is prepared) by 1000ml amount of preparation
1, it weighs xanthan gum 0.7g to set in clean container, a certain amount of water is added and is allowed to be swollen, static 12-15h obtains medical fluid
1, it is spare；
2, glycerol 200.0g, propylene glycol 150.0g are weighed, is added in above-mentioned medical fluid 1, stirring is allowed to dissolve or disperse, and obtains medicine
Liquid 2, it is spare；
3, it separately weighs paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, have
Propyl galate 0.8g, natrium adetate 0.8g, anhydrous citric acid 2.0g, sodium benzoate 3.0g, sorbierite 100g, citric acid three
Sodium 2.0g and Sucralose 3.0g is added in above-mentioned medical fluid 2, and stirring makes it dissolve, and is sequentially adding the red 2.5mg of temptation, hawthorn
Essence 5.0ml adds water to amount of preparation, and stirring dissolves it all, and with 0.35um filtering with microporous membrane, decompression degassing 30min is filled
Dress to get.
Embodiment 8
Stability test is carried out to above-described embodiment 1 to embodiment 7, investigates the clarity of medical fluid:
Test method: the medical fluid for taking above-described embodiment 1 to prepare to embodiment 7 each 10, every 10ml places 37 DEG C of constant temperature
It in case, monthly checks once, checks 12 months altogether, if it find that one has slight turbid or muddiness or serious in each embodiment
It is muddy, so that it may judgement be carried out in accordance with regulations.(inspection result see the table below).
Clarification indicates that slight turbid is indicated with "+" with "-"；Muddiness is indicated with " ++ "；Serious muddy " +++ " expression.
Inspection method:
Clarification: sample inversion is observed in the sun, no little particle or turbid phenomenon；
Slight turbid: sample inversion is observed in the sun, there is the slightly opaque sense of little particle or medical fluid；
It is muddy: sample inversion to be observed in the sun, granule number increases, and bottom of bottle has a small amount of precipitating, and medical fluid is opaque；
It is serious muddy: sample inversion is observed in the sun.Bottom of bottle has a large amount of precipitatings to generate, and jog precipitating is not vaporized, medicine
Liquid is without transparent feel.
Conclusion: investigating through stability test, and for embodiment 3 from 1st month to 12nd month, medical fluid remained clarification shape
State, other embodiments have different degrees of muddiness or slight turbid, so, embodiment 3 is preferred preparation method.
Embodiment 9
Investigate: ammonia phenol is cured the inhibiting effect for creating feritin Oral Liquid On Mice acetic acid twisting, illustrates its analgesic activity.
Test drug: ammonia phenol more creates feritin oral solution
Negative control: physiological saline；The production of Hunan Jin Jian pharmaceutcal corporation, Ltd, lot number 180101
Positive control: Rotundine Tablet: the production of Sichuan diffie spy pharmaceutcal corporation, Ltd, lot number 180403
Experimental method: taking Kunming mouse 50, weight 18-22g, is randomly divided into 5 groups, single oral gavage gives low dose of dosage
1.3ml/kg, middle dosage 2.6ml/kg, high dose 5.2ml/kg are measured, negative control is physiological saline, and positive control is rotundin
0.03g/kg, 1h after administration are injected intraperitoneally 0.7% acetic acid 10ml/kg, while using manual time-keeping, observe mouse appearance the immediately
Writhing number in writhing time (writhing incubation period) and 15min.Compared with the control group, statistical data is with X ± S for each administration group
It indicates.
Medicine analgesic percentage (%)=[(control group writhing number-administration group writhing number)/control group writhing number] *
100%
Table 1: ammonia phenol, which is cured, creates the analgesic activity (X ± S) that feritin oral solution causes logical mouse to glacial acetic acid
| Group | Incubation period t/min | Writhing number in 15min | Analgesia rate (%) |
| Physiological saline | 6.23±2.31 | 12.35±6.33 | |
| Rotundin | 1.23±4.54# | 0.79±3.02# | 93.60 |
| Low dosage | 4.23±2.32 | 6.24±6.55* | 49.47 |
| Middle dosage | 2.86±2.75* | 4.23±5.31# | 65.75 |
| High dose | 2.78±2.24* | 3.14±8.31# | 74.57 |
Compared with physiological saline group, * p < 0.05, #p < 0.01
Cause mice pain latent the result shows that this product middle dosage and high dose group and positive drug can effectively extend glacial acetic acid
Fu Qi, and mouse writhing number can be substantially reduced, there is stronger inhibiting effect to mouse acetic acid twisting, is imitated with certain analgesia
Fruit.
Claims (15)
1. ammonia phenol more creates feritin oral solution and preparation method thereof, it is characterised in that contain in every 1000ml in prescription: acetparaminosalol
Phenol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, xanthan gum 5-2.0g, propylene glycol 100.0-
500.0g, glycerol 100.0-300.0g, propylgallate 0.5-5.0g, natrium adetate 0.1-1.0g, anhydrous citric acid
0.5-3.0g, sodium benzoate 1.0-4.0g, sorbierite 50.0-200.0-5.0g, Sucralose 0.5-5.0g, trisodium citrate
0.5-3.0g, pigment 10.0-30.0mg, essence 0.5-5.0ml, Purified Water q. s.
2. ammonia phenol more creates feritin oral solution and preparation method thereof according to claim 1, it is characterised in that every in prescription
Can also contain in 1000ml: paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g,
Xanthan gum 0.95g, propylene glycol 300.0g, glycerol 200.0g, propylgallate 2.0g, natrium adetate 0.5g, anhydrous lemon
Sour 1.9g, sodium benzoate 2.0g, sorbierite 100.0g, Sucralose 2.5g, trisodium citrate 1.0g, pigment 28.5mg, essence
2.5ml, Purified Water q. s.
3. -3 any ammonia phenol more create feritin oral solution and preparation method thereof according to claim 1, it is characterised in that in prescription
It can also contain in every 1000ml: paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE
0.5g, xanthan gum 0.95g, propylene glycol 300g, glycerol 200g, propylgallate 2.0g, natrium adetate 0.5g, anhydrous lemon
Sour 1.9g, sodium benzoate 2.3g, sorbierite 100g, Sucralose 0.73g, trisodium citrate 2.2g, pigment 28.5mg, essence
2.5ml, Purified Water q. s.
4. -3 any ammonia phenol more create feritin oral solution and preparation method thereof according to claim 1, it is characterised in that in prescription
It is preferred that with containing in every 1000ml: paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE
0.5g, xanthan gum 1.0g, propylene glycol 250.0g, glycerol 200g, propylgallate 2.0g, natrium adetate 0.5g, anhydrous lemon
Lemon acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, Sucralose 2.5g, trisodium citrate 2.2g, the red 2.0mg of temptation, orange
Essence 2.5ml, Purified Water q. s.
5. -4 any preparation method according to claim 1 takes any prescription of aforesaid right 1-4, it is characterised in that system
Preparation Method is as follows:
5.1, recipe quantity xanthan gum, propylene glycol are weighed into clean container, stirring is allowed to be uniformly dispersed, and obtains medical fluid 1, spare；
5.2, propylgallate, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite, the citric acid of recipe quantity are weighed
Trisodium, Sucralose are set in clean container, are stirred to dissolve or evenly dispersed, are added in above-mentioned medical fluid 1, are continued to stir, be allowed to
It dissolves or is uniformly dispersed, obtain medical fluid 2, it is spare；
5.3, the glycerol for weighing recipe quantity is added in above-mentioned medical fluid 2 after adding a small amount of water to dilute, under stirring, sequentially adds
Paracetamol, guaiacol glycerol ether, the PHENYLEPHRINE HYDROCHLORIDE of recipe quantity, stirring make all dissolve after, successively plus
Pigment, the essence for entering recipe quantity, add water to amount of preparation, stir evenly, filter, degassing, dress to get.
6. -5 any preparation method according to claim 1 takes any prescription of aforesaid right 1-4, it is characterised in that system
Preparation Method may also is that
6.1, the xanthan gum of recipe quantity is weighed in clean container, a certain amount of water is added and is allowed to be swollen, and static 12-15h obtains medicine
Liquid 1, it is spare；
6.2, glycerol, the propylene glycol for weighing recipe quantity are added in above-mentioned medical fluid 1, and stirring is allowed to dissolve or disperse, and obtains medical fluid 2, standby
With；
6.3, recipe quantity paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE, gallic acid third are separately weighed
Above-mentioned medical fluid 2 is added in ester, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite, trisodium citrate and Sucralose
In, stirring makes it dissolve, and in pigment, the essence for sequentially adding recipe quantity, adds water to amount of preparation, stirring dissolves it all, mistake
Filter, degassing, it is filling to get.
7. -6 any preparation method according to claim 1 takes any prescription of aforesaid right 1-4, it is characterised in that system
Preparation Method may also is that
7.1, paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE, the gallic acid third of recipe quantity are weighed
Ester, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite, trisodium citrate and Sucralose are in Agitation Tank, mixing
Uniformly, medicinal mixture is obtained, it is spare；
7.2, recipe quantity glycerol, propylene glycol are weighed, after the dilution of a small amount of water, is added in said medicine mixture, stirring keeps its molten
Solution, is added pigment, the essence of recipe quantity, adds water to amount of preparation, and stirring makes it all after dissolution, filters, degassing, it is filling to get.
8. -7 any preparation method according to claim 1 takes any prescription of aforesaid right 1-4, it is characterised in that system
Preparation Method may also is that
8.1, it weighs recipe quantity xanthan gum to be added in the propylene glycol of recipe quantity, after stirring to dissolve or dispersing, recipe quantity is added
Glycerol, continue to stir to dissolve, obtain medical fluid 1, it is spare；
8.2, paracetamol, guaiacol glycerol ether, PHENYLEPHRINE HYDROCHLORIDE are sequentially added in medical fluid 1, stirring makes molten
Medical fluid 2 is solved, it is spare；
8.3, separately weigh respectively the propylgallate of recipe quantity, natrium adetate, anhydrous citric acid, sodium benzoate, sorbierite,
Trisodium citrate and Sucralose, it is 50-75 DEG C of water that a small amount of temperature, which is added, after stirring to dissolve, is added in above-mentioned medical fluid 2,
In pigment, the essence for sequentially adding recipe quantity, amount of preparation is added water to, is stirred, after dissolving it all, is filtered, degassing is filling,
To obtain the final product.
9. -8 any preparation method according to claim 1, it is characterised in that preferably with the preparation method is as follows:
9.1, xanthan gum 1.0g is weighed in Agitation Tank, a certain amount of water is added and is allowed to be swollen, and static 12-15h obtains medical fluid 1, standby
With；
9.2, glycerol 200g, propylene glycol 250g are weighed, is added in above-mentioned medical fluid 1, stirring is allowed to dissolve or disperse, and obtains medical fluid 2, standby
With；
9.3, it separately weighs paracetamol 32.5g, guaiacol glycerol ether 20.0g, PHENYLEPHRINE HYDROCHLORIDE 0.5g, eat
Sub- propyl propionate 2.0g, natrium adetate 0.5g, anhydrous citric acid 1.9g, sodium benzoate 2.3g, sorbierite 100g, trisodium citrate
2.2g and Sucralose 2.5g is added in above-mentioned medical fluid 2, and stirring makes it dissolve, and sequentially adding, the red 2.0mg of temptation, orange are fragrant
Smart 2.5ml adds water to amount of preparation, and stirring dissolves it all, and with 0.45um filtering with microporous membrane, decompression degassing 60min is filled
Dress to get.
10. according to any preparation method of claim 5-8, it is characterised in that the essence refers to flavoring pineapple essence or apple
The mixture of essence or orange essence or hawthorn essence one or more.
11. according to any preparation method of claim 5-8, it is characterised in that the pigment, refer to brilliant blue or temptation it is red its
One of.
12. according to any preparation method of claim 5-8, it is characterised in that the filtering refers to micro- with 0.35-0.60um
Hole membrane filtration.
13. according to any preparation method of claim 5-8, it is characterised in that the degassing refers to medical fluid decompression side
Method degassing 10-60min.
14. -4 any ammonia phenol more create feritin oral solution according to claim 1, feature has in the oral solution to be alleviated or controls
Treat nasal obstruction caused by flu and influenza, headache and slight pain, congestion of nasal sinus and pressure, bring down a fever, be sensible, to improve nasal cavity logical
The effects of gas, promotion nasal sinus drainage, resolving sputum, antibechic.
15. -4 any ammonia phenol more create feritin oral solution according to claim 1, it is characterised in that the oral solution is suitable for 12 years old
The above crowd takes, fruity.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811213974.2A CN109125257B (en) | 2018-10-18 | 2018-10-18 | Oral liquid of amino phenol guaiacol and renin and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811213974.2A CN109125257B (en) | 2018-10-18 | 2018-10-18 | Oral liquid of amino phenol guaiacol and renin and preparation method thereof |
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| CN109125257B CN109125257B (en) | 2020-12-01 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070197661A1 (en) * | 2006-02-21 | 2007-08-23 | Wyeth | Phenylephrine liquid formulations |
| CN101431991A (en) * | 2006-04-28 | 2009-05-13 | 宝洁公司 | Liquid compositions comprising phenylephrine and acetaminophen and their use for the treatment of respiratory illness |
| CN108187054A (en) * | 2013-02-28 | 2018-06-22 | 辉瑞公司 | The stability of the enhancing of new liq composition |
-
2018
- 2018-10-18 CN CN201811213974.2A patent/CN109125257B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070197661A1 (en) * | 2006-02-21 | 2007-08-23 | Wyeth | Phenylephrine liquid formulations |
| CN101431991A (en) * | 2006-04-28 | 2009-05-13 | 宝洁公司 | Liquid compositions comprising phenylephrine and acetaminophen and their use for the treatment of respiratory illness |
| CN108187054A (en) * | 2013-02-28 | 2018-06-22 | 辉瑞公司 | The stability of the enhancing of new liq composition |
Non-Patent Citations (1)
| Title |
|---|
| ANNICK JANIN等: "Bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a fixed-combination syrup versus an oral reference product", 《JOURNAL OF INTERNATIONAL MEDICAL RESEARCH》 * |
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| Publication number | Publication date |
|---|---|
| CN109125257B (en) | 2020-12-01 |
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