CN109124879A - Breast milk absorption pad - Google Patents
Breast milk absorption pad Download PDFInfo
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- CN109124879A CN109124879A CN201810679085.9A CN201810679085A CN109124879A CN 109124879 A CN109124879 A CN 109124879A CN 201810679085 A CN201810679085 A CN 201810679085A CN 109124879 A CN109124879 A CN 109124879A
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- China
- Prior art keywords
- breast milk
- inhibitor
- absorption pad
- fatty acid
- acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/14—Bandages or dressings; Absorbent pads specially adapted for the breast or abdomen
- A61F13/141—Milk breast pads
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41C—CORSETS; BRASSIERES
- A41C3/00—Brassieres
- A41C3/12—Component parts
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Textile Engineering (AREA)
- Corsets Or Brassieres (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Abstract
The present invention provides the breast milk absorption pad that can be adequately suppressed the stench generation due to breast milk.Breast milk absorption pad (1) of the invention includes that fatty acid generates inhibitor, inhibits the generation of the fatty acid of the Lipid sources in breast milk.
Description
Technical field
The present invention relates to the insides for being worn on the underwears such as brassiere the breast milk absorption pad that uses, more particularly to is able to suppress evil
The breast milk absorption pad of smelly generation.
Background technique
Known breast milk absorption pad prevents the breast milk of the lactications persons such as mother from leaking to the underwears such as brassiere.Above-mentioned breast milk is absorbed
Pad requires that the stench due to breast milk is inhibited to generate in recent years.
Usually it is known that amino acid is bacterially decomposed and ammonia, the organic acid etc. that generate (especially in field of food etc.)
It is considered as stench Producing reason, therefore by inhibiting the proliferation of bacterium that can reduce the foul smell of ammonia, organic acid of generation etc.
The amount of ingredient inhibits the generation of stench.
For example, Patent Document 1 discloses a kind of sanitary sheets, successively have: forming the nothing of the water penetration of upper surface
Woven fabric layer, the first paper layer portion of water imbibition, bibulous layer portion, water imbibition the second paper layer portion and formed lower surface plastics system
Impermeability film layer portion, aforementioned first paper layer portion by the tea containing more than one extract remaining waste dried object or it is a kind of with
On tea shell (tea grounds) the dried object of leachate or the tissue paper of mixture of their two kinds or more of dried object formed, into
And it also discloses and the sanitary sheet is used for the amenities such as newborn absorption pad.
According to the sanitary sheet disclosed in Patent Document 1, by contained in tissue paper, tea extract the dry of remaining waste
Dry object, tea shell leachate dried object or their mixture, be able to suppress Pseudomonas aeruginosa, staphylococcus aureus, legion
The proliferation of the bacteriums such as bacillus and streptococcus.
Existing technical literature
Patent document
Patent document 1: Japanese Unexamined Patent Publication 2000-129592 bulletin
Summary of the invention
Problems to be solved by the invention
However, can not even if the technology disclosed in Patent Document 1 for inhibiting bacterial multiplication is used for breast milk absorption pad yet
It is adequately suppressed the offending stink due to breast milk, status is the stench for not yet solving to generate in breast milk absorption pad.
In addition, as the means for inhibiting stench, the commonly known means using deodorizing ingredients such as deodorants, but above-mentioned means
Substantially by adsorbing stink odor generated with deodorizing ingredient to inhibit stench, rather than inhibit to become stench reason
Stink odor generation, therefore play its effect with being unable to fully if stink odor is not contacted with deodorizing ingredient.However, right
For breast milk absorption pad, such deodorizing ingredient is orally taken the photograph by the breast of wearer (lactication person) by baby in order to prevent
Take, the allocation position of deodorizing ingredient limited, it is different according to its allocation position and have can not fully play smelly eliminating at
Divide the worry of effect.
Therefore, the purpose of the present invention is to provide the suctions of the breast milk for the generation that can be adequately suppressed the stench due to breast milk
Receive pad.
The solution to the problem
The producing cause that the inventors of the present invention are directed to the stench due to breast milk is investigated further and has been analyzed, and is as a result sent out
It is existing: for the stench generated in breast milk absorption pad, find out compared with ammonia, organic acid that the decomposition due to bacterium generates etc.,
The decomposition enzyme hydrolysis as the lipase that also exists in breast milk of lipid contained in breast milk and the fatty acid (example generated
Such as, butyric acid, caproic acid, octanoic acid, capric acid, lauric acid etc.) it is the main reason for generating stench, in turn, by inhibiting the fatty acid
Itself is generated, so as to the generation for the stench being adequately suppressed in breast milk absorption pad, so far completes the present invention.
A mode (mode 1) of the invention is a kind of breast milk absorption pad, and it includes fatty acid to generate inhibitor, the fat
Acid generates the generation of the fatty acid of the Lipid sources in inhibitor inhibition breast milk.
The breast milk absorption pad of which includes that the fatty acid for inhibiting the fatty acid of the Lipid sources in breast milk to generate generates suppression
Preparation, therefore inhibit the generation of the fatty acid for the reason of becoming offending stink, it as a result can be adequately suppressed breast milk absorption
The generation of the stench from breast milk in pad.
In addition, in the breast milk absorption pad of aforesaid way 1, aforementioned fatty acids are carbon in another way (mode 2) of the invention
The short chain fatty acids of number 2~6.
For the breast milk absorption pad of which, with it is in the fatty acid of the Lipid sources in breast milk, become unhappy and strong
The short chain fatty acids of the carbon number 2~6 of the reason of strong stink as target and inhibit its generation, it is thus possible to more effectively inhibit
The generation of above-mentioned stench.
In another way (mode 3) of the invention, in the breast milk absorption pad of aforesaid way 1 or 2, aforementioned fatty acids be selected from
At least one of the group being made of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid fatty acid.
For the breast milk absorption pad of which, by the fatty acid for inhibiting the object generated be limited to selected from by acetic acid, propionic acid,
Isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid composition at least one of group fatty acid, therefore by inhibit particularly into
The generation of these fatty acid of the reason of unhappy and strong stink, so as to more acurrate and effectively inhibit the production of stench
It is raw.
In another way (mode 4) of the invention, in the breast milk absorption pad of any one of foregoing manner 1~3, aforementioned fat
It is the activity inhibitor for lipase that acid, which generates inhibitor,.
For the breast milk absorption pad of which, it is the activity inhibitor for lipase that fatty acid, which generates inhibitor, therefore
It, can be reliably by inhibiting the activity of lipase contained in breast milk that lipid contained in breast milk is made to become to be not easy to be hydrolyzed
Inhibit the generation of fatty acid.
In another way (mode 5) of the invention, in the breast milk absorption pad of aforesaid way 4, aforementioned lipase is lipoprotein
Lipase.
For the breast milk absorption pad of which, it is the activity suppression for lipoprotein lipase that fatty acid, which generates inhibitor,
Agent, therefore by inhibiting lipase contained in breast milk (that is, lipoprotein lipase (Liporotein Lipase) and bile acid
Activation lipase (Bile Salt-Stimulated Lipase)) in, particularly the lipid water that is believed to be helpful in breast milk
The activity of the lipoprotein lipase of solution, so that the lipid in breast milk is further made to be not easy to be hydrolyzed, it can be more reliable and effective
The generation of ground inhibition fatty acid.
In another way (mode 6) of the invention, in the breast milk absorption pad of aforesaid way 4 or 5, foregoing active inhibitor exists
There is galloyl in molecular structure.
For the breast milk absorption pad of which, there is nutgall acyl in the molecular structure for the activity inhibitor of lipase
Base, thus the galloyl of activity inhibitor in conjunction with the active group of lipase for facilitating the lipid hydrolysis in breast milk simultaneously
The state that antagonism inhibits is formed, thus the lipid in breast milk is more reliably made to be not easy to be hydrolyzed, can be more reliable and effectively pressed down
The generation of fatty acid processed.
In another way (mode 7) of the invention, in the breast milk absorption pad of any one of aforesaid way 4~6, foregoing active
Inhibitor is the Polyphenols with galloyl.
For the breast milk absorption pad of which, the activity inhibitor for lipase is the polyphenol with galloyl
Class, therefore the state that above-mentioned antagonism inhibits is more readily formed, it can be easier and be reliably suppressed the generation of fatty acid.
In another way (mode 8) of the invention, in the breast milk absorption pad of aforesaid way 7, aforementioned Polyphenols is derived from plant
Object bark, the beans tea Cassia of leguminous plant, tea or persimmon polyphenol.
For the breast milk absorption pad of which, the activity inhibitor for lipase is with galloyl, is originated from
Plant bark, the beans tea Cassia of leguminous plant, tea or persimmon polyphenol, therefore as described above, can more reliably inhibit fatty acid
Generation, and the activity inhibitor as contained by breast milk absorption pad is originated from natural component, thus wearer can be made to be not easy to feel
To the influence of human body (that is, skin face to wearer and to can be passed through via the skin face as caused by above-mentioned activity inhibitor
The influence of the baby of mouthful intake) etc. uneasy sense (in other words, can be to wearer with reassurance).
In another way (mode 9) of the invention, in the breast milk absorption pad of aforesaid way 7 or 8, also inhibit comprising discoloration
Agent, the discoloration inhibitor inhibit aforementioned fatty acids to generate inhibitor discoloration.
For the breast milk absorption pad of which, since the discoloration also comprising inhibiting fatty acid to generate inhibitor discoloration inhibits
Agent, therefore generate inhibitor by the inclusion of the fatty acid of above-mentioned specific Polyphenols and the generation of fatty acid can be adequately suppressed,
And by the inclusion of above-mentioned discoloration inhibitor, so as to make to generate due to fatty acid the Polyphenols oxidation of inhibitor, discoloration and to
Wearer brings the case where uneasy sense, discomfort to be not likely to produce.
In another way (mode 10) of the invention, in the breast milk absorption pad of aforesaid way 9, aforementioned discoloration inhibitor is anti-
Oxidant.
For the breast milk absorption pad of which, it is anti-oxidant for inhibiting fatty acid to generate the discoloration inhibitor of inhibitor discoloration
Agent, therefore it is able to suppress the oxidation of Polyphenols itself that fatty acid generates inhibitor, so that the fatty acid is generated inhibition
The case where agent changes colour is not likely to produce.
In another way (mode 11) of the invention, in the breast milk absorption pad of any one of aforesaid way 9~10, aforementioned change
Color inhibitor includes the water that the solvent of inhibitor is generated as aforementioned fatty acids.
For the breast milk absorption pad of which, inhibiting fatty acid to generate the discoloration inhibitor of inhibitor discoloration includes to be used as rouge
Fat acid generates the water of the solvent of inhibitor, therefore can reliably control the generation that above-mentioned fatty acid generates the discoloration of inhibitor
(that is, electrochromic variable can be made to obtain unobtrusively), while wearer can also be made to be not easy to feel right as caused by discoloration inhibitor (that is, water)
The uneasy sense such as influence of human body.
In another way (mode 12) of the invention, in the breast milk absorption pad of any one of aforesaid way 1~11, aforementioned mother
Newborn absorption pad includes the inner surface sheet material positioned at the skin surface side of wearer and the non-skin surface side positioned at the inner surface sheet material
Absorber, aforementioned fatty acids generate inhibitor be configured between inner surface sheet material and said absorbent.
For the breast milk absorption pad of which, inner surface sheet material and absorber are configured in since fatty acid generates inhibitor
Between, therefore fatty acid can be made to generate inhibitor and contacted with the breast milk before absorber is absorbed into, the fatty acid can be made to generate and pressed down
Preparation more reliably acts on breast milk.In addition, fatty acid generation inhibitor is configured in non-skin face compared with inner surface sheet material
When side, fatty acid generates inhibitor and is not easy to be attached to the skin face of wearer, in turn, it is difficult to via the flesh of wearer (lactication person)
Skin face and by baby's oral uptake, therefore wearer can be made to be not easy to feel and generated caused by inhibitor as above-mentioned fatty acid to people
The uneasy sense such as influence of body.
In another way (mode 13) of the invention, in the breast milk absorption pad of any one of aforesaid way 1~12, aforementioned rouge
Fat acid generates inhibitor and is configured in the highest sheet material of density in the multiple sheet materials for constituting aforementioned breast milk absorption pad.
For the breast milk absorption pad of which, fatty acid generates multiple that inhibitor is configured in composition breast milk absorption pad
The highest sheet material of density in material, therefore fatty acid generates inhibitor and is not easy to move because of the activity of wearer, flowing of breast milk etc.,
The effect that the fatty acid generates inhibitor can be more reliably played, and fatty acid generates inhibitor and is easy to become because of oxidation etc.
When color, it can be not easy to recognize the discoloration of fatty acid generation inhibitor by the sheet material of above-specified high density.
Another way (mode 14) of the invention is that the fatty acid of breast milk absorption pad generates inhibitor, is inhibited in breast milk
Lipid sources fatty acid generation.
The fatty acid of the breast milk absorption pad of which generates the mother that inhibitor inhibits the reason of becoming offending stink
Generation of fatty acid of Lipid sources in cream itself, therefore mother is originated from the result is that can be adequately suppressed in breast milk absorption pad
The generation of the stench of cream.
The effect of invention
In accordance with the invention it is possible to provide the breast milk absorption pad for the generation that can be adequately suppressed the stench due to breast milk.
Detailed description of the invention
Fig. 1 is the vertical of the breast milk absorption pad 1 of one embodiment of the present invention from outer 5 side of packaging sheet (non-skin surface side)
Body figure.
Fig. 2 is in the expanded state from 2 side of inner surface sheet material (skin surface side) through-thickness DTBreast milk is observed to absorb
The top view of pad 1.
Fig. 3 is to make the breast milk absorption pad 1 of Fig. 2 along in lateral DCThe longitudinally central axis C extended2Sectional view.
Description of symbols
1 breast milk absorption pad
2 inner surface sheet materials
3 outer surface sheets
4 absorption components
41 absorbers
The cover sheets of 42 skin surface sides
The cover sheets of 43 non-skin surface sides
5 outer packaging sheets
6 adhered portions
Specific embodiment
Hereinafter, the suitable embodiment of breast milk absorption pad of the invention is described in detail while referring to attached drawing.It needs
It is noted that in this specification, it will be " from the upper side of vertical direction along the thickness direction of object when being not particularly illustrated
The case where object (for example, breast milk absorption pad etc.) in the horizontal plane is placed in observation in the expanded state " is referred to as " bowing
Depending on ".
It is as follows when being not particularly illustrated for various directions etc. used in this specification.
In this specification, " longitudinal D of breast milk absorption padL" refer to: for " breast milk absorption pad when vertical view, wears the mother
As the direction of up and down direction when newborn absorption pad ", " lateral DC" refer to: for " breast milk absorption pad when vertical view, wears the breast milk
Become the direction of left and right directions (horizontal direction) when absorption pad ", " thickness direction DT" refer to " and be placed in the expanded state
The vertical direction of breast milk absorption pad on horizontal plane ", these longitudinal directions DL, transverse direction DCWith thickness direction DTIt is in orthogonal pass each other
System.
In addition, in this specification, for the thickness direction D of breast milk absorption padT, will be " when wearing breast milk absorption pad, with wearing
The skin face of person is opposite proximal side " it is known as " skin surface side ", by " when wearing breast milk absorption pad, the skin face with wearer is
Opposite far side " is known as " non-skin surface side ".Herein, refer to " when wearing " from wearer wear breast milk absorption pad at the time of (that is,
At the time of forming the state that can be used) it rises and maintains during the state (that is, during wearing).
Fig. 1 is the vertical of the breast milk absorption pad 1 of one embodiment of the present invention from outer 5 side of packaging sheet (non-skin surface side)
Body figure, Fig. 2 are in the expanded state from 2 side of inner surface sheet material (skin surface side) through-thickness DTObserve breast milk absorption pad 1
Top view.In addition, Fig. 3 is to make the breast milk absorption pad 1 of Fig. 2 along in lateral DCThe longitudinally central axis C extended2Sectional view.
As shown in FIG. 1 to 3, the breast milk absorption pad 1 of one embodiment of the present invention has the longitudinal D being mutually orthogonalL, it is horizontal
To DCWith thickness direction DT, when looking down, the lateral D with circular shapeCBoth ends respectively by along longitudinal DLExtend
Straight line cutting sample outer shape.It should be noted that the outer shape of breast milk absorption pad is not limited to this in the present invention
Mode, as long as covered in a manner of it can wrap up wearer's breast, then it can be using arbitrary outer shape (for example, round, ellipse
It is round, fillet rectangular etc.).
In addition, the breast milk absorption pad 1 in for the above embodiment, as shown in figure 3, in thickness direction DT, as basic
Composition has: positioned at the skin surface side S of wearer1Liquid permeability inner surface sheet material 2, be located at non-skin surface side S2Non- transparent liquid
The outer surface sheet 3 of property, positioned at the absorption component 4 between them, and then have: outer packaging sheet 5, via hot melt adhesive
Etc. the non-skin surface side S that arbitrary adhesive layer (not shown) is bonded on outer surface sheet 32Surface and with from non-skin surface side
S2Cover the lateral D of outer surface sheet 3CBoth ends and make lateral DCBoth ends to skin surface side S1It folds；1 pair of elastic structure
Part EL is clamped in the part of the outer packaging sheet 5 being folded and in longitudinal DLExtend (it should be noted that this embodiment party
In formula, as shown in figure 3, in lateral DCAn end part being folded and the part that the other end is folded be each configured with
1 couple of (amounting to 4) elastic component EL.)；And adhered portion 6, configure the non-skin surface side S in outer packaging sheet 52Surface and be
In longitudinal DL4 adhered portions of the strip of extension, it includes adhesives etc..It should be noted that this other than adhered portion 6
A little member of formation are formed between each component through stepped construction made of the arbitrary bonding agent engagement such as hot melt adhesive.
For above-mentioned breast milk absorption pad 1, by configuring the non-skin surface side S in outer packaging sheet 52Surface adhered portion 6
And it is removably attached to the surface on the inside of wearer's underwear (for example, brassiere etc.), then to cover wearer's breast at least
One mode contacts the skin surface side S of inner surface sheet material 21Surface come using.
In addition, for the breast milk absorption pad 1 of present embodiment, as shown in figure 3, absorption component 4 is made of such as lower member: logical
The absorber 41 crossing the absorbent material (for example, pulp, superabsorbent polymer etc.) that can be absorbed and keep breast milk and being formed；
To cover the skin surface side S of the absorber 411The skin surface side S that the mode on surface configures1Cover sheets 42；And covering absorbs
The non-skin surface side S of body 412Surface and with from non-skin surface side S2The mode of package absorber 41 and cover sheets 42 configures non-
Skin surface side S2Cover sheets 43, in turn, in above-mentioned skin surface side S1Cover sheets 42 configured with inhibit breast milk in lipid
The fatty acid of the generation of the fatty acid in source generates inhibitor.It should be noted that fatty acid generates inhibition in present embodiment
Agent, which is dissolved in, forms aqueous solution as the water of solvent, and the aqueous solution is then coated in skin surface side S1Cover sheets 42 table
Face configures.
The breast milk absorption pad 1 of present embodiment includes the generation for inhibiting the fatty acid of the Lipid sources in breast milk as a result,
Fatty acid generates inhibitor, therefore the generation of fatty acid itself the reason of be able to suppress as offending stink, the result is that
The generation of the stench from breast milk can be adequately suppressed.
In turn, in present embodiment, above-mentioned fatty acid generates inhibitor and is configured in positioned at inner surface sheet material 2 and absorber
Skin surface side S between 411Cover sheets 42, therefore fatty acid generate inhibitor be easy be absorbed body 41 absorb before mother
Cream contact makes the fatty acid generate inhibitor and more reliably acts on breast milk.In addition, being located at by making fatty acid generate inhibitor
Non- skin surface side S2Rather than inner surface sheet material 2, it is not easy to be attached to the skin face of wearer so that fatty acid generates inhibitor, into
And be not easy skin face via wearer (lactication person) and by baby's oral uptake, therefore can make wearer be not easy to feel by
Above-mentioned fatty acid generates the uneasy sense such as influence caused by inhibitor to human body.
The main composition that 1 pair of breast milk absorption pad of above embodiment used below constitutes breast milk absorption pad of the invention is wanted
Element is described in more detail.
[fatty acid generation inhibitor]
In above embodiment, for breast milk absorption pad 1, in the skin surface side S for being located at absorber 411Skin surface side S1
Cover sheets 42 configured with inhibit breast milk in Lipid sources fatty acid generation fatty acid generate inhibitor.Above-mentioned rouge
It is to penetrate the inner surface sheet material 2 of breast milk absorption pad 1 in the breast milk being discharged from wearer and reach above-mentioned flesh that fat acid, which generates inhibitor,
Skin surface side S1Cover sheets 42 when, to inhibit lipase (the mainly rouge egg contained in breast milk as the catabolic enzyme of lipid
White lipase) activity inhibitor that plays a role of active mode.More specifically, activity suppression used in present embodiment
Agent be by conjunction with the active group of the lipid hydrolysis facilitated in the breast milk in lipase and formed antagonism inhibition state,
To make the lipid in breast milk be not easy one kind of hydrolyzed so-called enzyme inhibitor.
It should be noted that in the present invention, as long as fatty acid, which generates inhibitor, can inhibit lipid contained in breast milk
The substance of the generation of the fatty acid in source is just not limited to above-mentioned activity inhibitor, such as can also use to be formed and be difficult to generate
The reaction condition of the hydrolysis of aftermentioned such lipid as caused by lipase itself, the substance of reaction environment, i.e. hydrolysis are anti-
The regulator (for example, pH adjusting agent, exothermic mixture etc.) etc. of the inhibitor (for example, dehydrating agent etc.), reaction environment answered.
In above embodiment, inhibitor is generated as fatty acid, uses the activity for being directed to lipase contained in breast milk
Inhibitor, therefore it is able to suppress the activity for making the lipase of lipid hydrolysis contained in breast milk, and be able to suppress due to above-mentioned water
The generation of solution and the fatty acid such as butyric acid, caproic acid, octanoic acid, capric acid, lauric acid of generation, the result is that breast milk suction can be adequately suppressed
Receive the generation of the stench from breast milk in pad 1.
Can deduce herein: main lipid contained in breast milk be oleic acid (the unitary unsaturated fatty acid of carbon number 18),
The triglycerides that palmitinic acid (saturated fatty acid of carbon number 16) and linoleic acid (the binary unsaturated fatty acid of carbon number 18) are combined,
The triglycerides due to lipase effect and it is hydrolyzed when, oleic acid selectively dissociates with linoleic acid, in turn, the linoleic acid by
It is decomposed in enzymatic hydrolysis, oxygenolysis etc., thus generates the various fatty acid as stench reason (for example, butyric acid, caproic acid, pungent
The fatty acid such as acid, capric acid, lauric acid).
In various fatty acid as this stench reason, the short chain fatty acids of carbon number 2~6, especially acetic acid, propionic acid,
Isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid have the stink for assigning strong discomfort, and the stink is strong (that is, i.e.
Make for that can also feel its stink on a small quantity), therefore in the present invention, fatty acid generates inhibitor and preferably inhibits such carbon number 2~6
Short chain fatty acids generation, particularly preferably inhibit selected from by acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid group
At at least one of group fatty acid generation.By by the carbon number 2 of this reason of becoming unhappy and strong stink
~6 short chain fatty acids are as target and inhibit its generation, so as to more effectively inhibit the stench in breast milk absorption pad
It generates.In turn, by being limited to the fatty acid for inhibiting the object generated particularly into unhappy and strong stink reason
, selected from least one of the group being made of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid fatty acid, and
Inhibit the generation of these fatty acid, so as to more reliable and effectively inhibit the generation of stench.
As long as the fatty acid generation inhibitor in the present invention can inhibit the fatty acid of Lipid sources contained in breast milk
Generation is just not particularly limited, for example, may be used also other than the activity inhibitor for being directed to lipase as above embodiment
With use the reaction condition to form the hydrolysis itself for being not likely to produce the lipid as caused by lipase, reaction environment substance,
That is the regulator (for example, pH adjusting agent, exothermic mixture etc.) etc. of the inhibitor (for example, dehydrating agent etc.) of hydrolysis, reaction environment.
Although the regulator of the inhibitor of hydrolysis, reaction environment not with breast milk contained in lipase active group in conjunction with (that is,
Do not act on lipase itself), but the reaction of hydrolysis itself as being not susceptible to the lipid as caused by lipase,
It is to inhibit the substance of the generation of fatty acid, such as can enumerate: dehydrating agent, the desiccant of moisture contained in removal breast milk；It will
The pH that the pH of breast milk is adjusted to the alkalescent (preferably pH9.5 or more) for being not easy to carry out the hydrolysis as caused by lipase is adjusted
Agent；The hair for the temperature (preferably 50 DEG C or more) that the temperature of breast milk is heated to being not easy to carry out the hydrolysis as caused by lipase
Thermit powder etc..
These various fatty acid generate in inhibitor, and the actual effect of inhibitory effect is generated from the fatty acid in breast milk absorption pad
With from the perspective of the safety of influence that is generated to human bodies such as wearer, babies etc., it is preferable to use for above-mentioned lipase
Activity inhibitor.Such activity inhibitor with other fatty acid generate inhibitor compared with, no matter breast milk composition individual difference,
The influence of wearing state, the wearing environment of breast milk absorption pad etc. is how, is easy to inhibit the activity of lipase contained in breast milk,
Therefore it can more reliably make lipid contained in breast milk be not easy to be hydrolyzed, can more reliably inhibit the generation of fatty acid.
It should be noted that activity inhibitor inhibits the active form of lipase to be not particularly limited in the present invention, remove
Above embodiment is such by combining with the active group for facilitating hydrolysis in lipase and forming what antagonism inhibited
State, come inhibit hydrolysis reaction start form except, can also be by with the above-mentioned active group in lipase
The different position of group combines, and forms the state (non-antagonist inhibition) for being difficult to that above-mentioned active group is made to act on lipid, from forming
For the form for inhibiting hydrolysis to carry out, the form for combining these each forms can also be.
In turn, in the present invention, it is preferably the activity inhibitor for being directed to lipoprotein lipase that fatty acid, which generates inhibitor,.Fat
When acid generates inhibitor as the activity inhibitor of lipoprotein lipase, lipase contained in breast milk is (that is, lipoprotein is fatty
Enzyme and bile acid activation lipase) in, inhibit the lipoprotein lipase for being considered mainly helping the lipid hydrolysis in breast milk
Activity, therefore the lipid in breast milk can be made to be difficult to further be hydrolyzed, it being capable of life that is more reliable and effectively inhibiting fatty acid
At.
In the present invention, as the activity inhibitor for the lipase that can be used as fatty acid generation inhibitor, as long as can play
Effect of the invention is just not particularly limited, for example, in addition to the tea catechin extracted from the tealeaves such as green tea, black tea, oolong tea
Equal catechins；The tannins such as the persimmon tannin extracted from puckery persimmon；Chinese herbaceous peony, the coptis, Cortex Phellodendri, cortex moutan, geranium wilfordii, hardship
The extract of the Chinese medicines such as ginseng, Radix Angelicae Pubescentis, galangal, betel nut, bayberry bark, cassia seed；Green pepper, pumpkin, dried mushroom of growing thickly, grifola frondosa,
The extract of the wholefoods raw material such as sargassum fusifome, apple, Korean ginseng, ginger；Japanese cypress, grape seed, persimmon leaves, spun gold
Peach, the wild bark of Chinese parasol tree, the fruit of Fructus Corni, the fruit of TERMINALIA CATAPPA, the leaf of Cortex Eucommiae, the leaf of yucca or seed, jasmine
Colored or leaf, the fruit of hawthorn, soybean germ, leguminous plant the plants such as the leaf of beans tea Cassia (for example, yellow Chinese scholartree etc.) extraction
Object etc. is originated from except natural ingredient (the especially Polyphenols such as catechin, tannins), can also use Cetilistat, Ao Li
It takes charge of he, suppression lipase and drug ingedients such as ketone B etc. is immunized.
In such activity inhibitor, from the aspect of activity suppression effect, there is nutgall acyl in preferred molecular structure
The substance of base, and then more preferably with the Polyphenols of galloyl, particularly preferably it is originated from the beans tea of plant bark, leguminous plant
Cassia, tea or persimmon, polyphenol with galloyl.
Activity inhibitor be in the molecular structure with galloyl substance when, above-mentioned galloyl with facilitate
The active group of the lipase of lipid hydrolysis combines and forms the state of antagonism inhibition, therefore more reliably makes the lipid in breast milk
It is not easy to be hydrolyzed, generation that is more reliable and effectively inhibiting fatty acid.In turn, activity inhibitor is with the more of galloyl
When phenols, become easier to form the state that above-mentioned antagonism inhibits, therefore can be easier and be reliably suppressed the life of fatty acid
At.In particular, there is the Polyphenols of galloyl to be derived from plant bark, the beans tea Cassia of leguminous plant, tea or persimmon for this
When polyphenol, it can more accurately inhibit the generation of fatty acid, and the activity suppression as contained by breast milk absorption pad as described above
Agent is originated from natural component, therefore is not easy to feel wearer as caused by the activity inhibitor to uneasinesses such as the influences of human body
Sense.As such polyphenol with galloyl, in addition to Epigallo-catechin gallate (EGCG) (EGCg), epicatechin
The gallates such as gallate (ECg), catechin and gallate (Cg), nutgall catechin gallic acid ester (GCg)
Except type catechin, persimmon tannin etc. can be enumerated.
It should be noted that in the above-mentioned polyphenol with galloyl, catechin and gallate and galla turcica
Catechin gallate there's almost no in the natural plants comprising tealeaves, therefore can be by not having to epigallocatechin
Infanticide acid esters, L-Epicatechin gallate or their mixture are heated (for example, 80 DEG C or more) to carry out heat
Isomerization (epimerization) and obtain.
[discoloration inhibitor]
In addition, breast milk absorption pad include above-mentioned Polyphenols as fatty acid generation inhibitor when, breast milk absorption pad preferably into
One step includes discoloration inhibitor, and the discoloration inhibitor inhibits the discoloration of fatty acid generation inhibitor.Breast milk absorption pad includes this
When the discoloration inhibitor of sample, the production that inhibitor is adequately suppressed fatty acid can be generated by the inclusion of the fatty acid of above-mentioned Polyphenols
It is raw, and the Polyphenols that fatty acid can be inhibited to generate inhibitor by discoloration inhibitor aoxidizes discoloration.Thereby, it is possible to make to wear
Wearer is not easy to feel the situation that the uneasy sense because of fatty acid generation inhibitor discoloration generation, discomfort are such.
In the present invention, as long as discoloration inhibitor can inhibit the fatty acid comprising above-mentioned Polyphenols to generate inhibitor discoloration
Substance be just not particularly limited, such as in addition to vitamins, two fourths such as vitamin C (ascorbic acid), vitamin Es (tocopherol)
It can also be used as rouge except the antioxidants such as base hydroxy-methylbenzene (BHT), butylated hydroxy anisole (BHA), arabo-ascorbic acid
Fat acid generates the water etc. of the solvent of inhibitor.
Above-mentioned antioxidant inhibits fatty acid to generate the oxidation of Polyphenols of inhibitor itself, therefore can more reliably make
The discoloration that the fatty acid generates inhibitor is not likely to produce.In addition, the water as discoloration inhibitor is due to making fatty acid generate inhibition
The concentration of aqueous solution of agent is reduced and can easily be added, and thereby, it is possible to reliably control above-mentioned fatty acid to generate inhibitor
The generation (that is, electrochromic variable can be made to obtain unobtrusively) of discoloration, at the same can also make wearer be not easy to feel by discoloration inhibitor (that is,
Water) caused by the uneasy sense such as influence to human body.
In addition, in the present invention, can also replace above-mentioned discoloration inhibitor or together with discoloration inhibitor, have and hidden include
The fatty acid of above-mentioned Polyphenols generates the hidden unit of discoloration of the discoloration of inhibitor.
As such hidden unit of discoloration, as long as capableing of the substance of the discoloration of hidden above-mentioned fatty acid generation inhibitor
It is just not particularly limited, such as can enumerate: color sheet made of being coloured by colorant (for example, pigment, dyestuff etc.),
The colorant be above-mentioned fatty acid generate the color after the discoloration of inhibitor can not from the skin surface side of breast milk absorption pad and/or
The color (cryptic coloration) or the color after above-mentioned discoloration is made to become inconspicuous color (benefit that the surface of non-skin surface side is recognized
Color) colorant；Concealment sheet material with highdensity sheet material etc., the high density are that above-mentioned fatty acid generates inhibitor
What the color after discoloration can not be recognized or be difficult to from the skin surface side of breast milk absorption pad and/or the surface of non-skin surface side to recognize
Degree, these concealment sheet materials can also separately configure containing fatty acid generate inhibitor sheet material skin surface side and/or
The position of non-skin surface side can also be the sheet material itself that inhibitor is generated containing fatty acid, can also be inner surface sheet material, outer
The flat member of the composition breast milk absorption pad of surficial sheets, outer packaging sheet etc..
[inner surface sheet material]
In above embodiment, as shown in Figures 2 and 3, when looking down, inner surface sheet material 2 used in breast milk absorption pad 1
With longitudinal D from breast milk absorption pad 1LOne side edge extend to the edge of the other side and from lateral DCOne side edge to
The same outer shape of whole outer shape and outer dimension that the edge of the other side extends, with breast milk absorption pad 1 and outside
Shape size, and being formed by the flat member of liquid permeability, the thickness direction of the flat member of the liquid permeability in breast milk absorption pad 1
DTIt is configured in the skin surface side S that can be contacted with the skin face (specifically, skin face of the breast of wearer) of wearer1
Position and can make from wearer be discharged breast milk fast transfer to be located at non-skin surface side S2Absorption component 4.
It should be noted that the outer shape of inner surface sheet material is not limited to the shape of this ad hoc fashion in the present invention,
As long as the shape that can be covered in a manner of wrapping up wearer's breast can be using arbitrary outer shape (for example, round, ellipse
It is round, fillet rectangular etc.).
It, can be through the defined of breast milk as long as having as the flat member for the liquid permeability that can be used as inner surface sheet material
The substance of liquid permeability is just not particularly limited, such as can properly use the non-woven fabrics such as Breathable nonwoven, spun-bonded non-woven fabrics, knit
The fiber construct (that is, fibre sheet material) of the sheet of cloth, knitted fabric etc.；Aperture resin film etc. with multiple aperture portions.On
Hydrophilicity-imparting treatment can also be implemented using surfactant by stating flat member, in addition it can appoint comprising deodorant, antibacterial agent etc.
The additive of meaning.It should be noted that can be used alone these additives, can also be applied in combination two or more.
When using above-mentioned fibre sheet material as inner surface sheet material, fiber is constituted for it and is not particularly limited, such as can be arranged
It enumerates: crushing the semisynthetic fibres cellulose fibers such as regenerated celulose fibres, the acetic acid esters such as cellulose fibres, the artificial silks such as pulp, cotton
Equal cellulose fibres；By polyolefin-based resins such as polyethylene, polypropylene；The polyester based resins such as polyethylene terephthalate
Equal thermoplastic resins；Or the resin that the thermoplastic resin composition of two or more these thermoplastic resins of any combination is formed is fine
Dimension etc., can be used alone these fibers, two or more fibers can also be applied in combination.
In addition, constitute resin when using above-mentioned aperture resin film as inner surface sheet material and be not particularly limited, such as
It can enumerate: the polyolefin-based resins such as polyethylene, polypropylene；The polyester based resins such as polyethylene terephthalate, polylactic acid；
The thermoplastic resins such as the polyamide resins such as 6- nylon；Or any combination thermoplastic resin of these two or more thermoplastic resins
Oil/fat composition etc..
It should be noted that outer dimension (the thickness of the flat member for the liquid permeability that can be used as inner surface sheet material
Deng), base weight etc., do not limited especially as long as the inner surface sheet material that above-mentioned flat member can be used as breast milk absorption pad plays a role
System can use the arbitrary outer dimension according to desired liquid permeability, intensity etc., base weight etc..
[outer surface sheet]
In above embodiment, when looking down, outer surface sheet 3 used in breast milk absorption pad 1 has can be in breast milk
Longitudinal D of absorption pad 1LWith lateral DCExtend and cover the most surfaces of the non-skin surface side of absorption component 4 (for example, absorbing structure
The non-skin surface side S of part 42Surface area 60% with first-class), defined outer shape and outer dimension, and by non-
The flat member of liquid permeability is formed, thickness direction D of the liquid-impermeable flat member in breast milk absorption pad 1TIt is configured in
The non-skin surface side S of absorption component 42And can make the mother that (in particular, absorption component 4) is absorbed and be maintained in breast milk absorption pad 1
Cream is not leaked out to the external of breast milk absorption pad 1.It should be noted that outer surface sheet 3 is viscous via heat molten type in present embodiment
Meet the non-skin surface side S of the arbitrary adhesive layer (not shown) and absorption component 4 such as agent2A part of surface engagement.
In the present invention, as long as the outer shape of outer surface sheet can play the shape of the effect as outer surface sheet
Just it is not particularly limited, it can be using arbitrary outer shape (for example, the rectangular or and inner surface of round, ellipse, fillet
Same shape of sheet material etc.).
As the liquid-impermeable flat member that can be used as outer surface sheet, as long as having the rule that can prevent breast milk from penetrating
Fixed liquid-impermeable (further preferably having both the substance of aeration) is just not particularly limited, for example, can properly use by
Implement water-proofing treatment or with hydrophobic synthetic resin fiber formed, SMS non-woven fabrics, spun-bonded non-woven fabrics, point bonding nothing
The non-woven fabrics such as woven fabric have hole or non-porous resin sheet etc. by what synthetic resin material was formed.Above-mentioned flat member can also wrap
Containing the arbitrary additive such as deodorant, antibacterial agent, these additives may be used alone, can also be used in combination two or more.
In addition, when using above-mentioned non-woven fabrics or resin sheet as outer surface sheet, constituent material (when for non-woven fabrics,
Form the material of the composition fiber of the non-woven fabrics) as long as being not particularly limited as long as inhibiting liquid-impermeable, such as can be suitably
Use the polyolefin-based resins such as polyethylene, polypropylene；The thermoplastic resins such as the polyester based resins such as polyethylene terephthalate；
Or any combination thermoplastic resin composition etc. of these two or more thermoplastic resins.
It should be noted that can be used as outer dimension, base weight of liquid-impermeable flat member of outer surface sheet etc. only
The outer surface sheet for wanting above-mentioned flat member to can be used as breast milk absorption pad plays a role and is just not particularly limited, and can use basis
Desired liquid-impermeable equal arbitrary outer dimension, base weight etc..
In addition, having such outer surface sheet not being for breast milk absorption pad of the invention is that necessary structure is wanted
It asks, therefore when such as can be used as the case where outer surface sheet plays a role in aftermentioned outer packaging sheet, breast milk absorption pad can be with
Do not have such outer surface sheet.
[absorber]
In above embodiment, as shown in Fig. 2, when looking down, absorption component 4 used in breast milk absorption pad 1 is located at packet
The central portion for including breast milk absorption pad 1 (is included in longitudinal direction DLThe lateral center axis C of extension1With in lateral DCWhat is extended is longitudinally central
Axis C2Intersection point part) region, have the whole outer shape with above-mentioned breast milk absorption pad 1 same, substantially round
The lateral D of shape shapeCBoth ends by longitudinal DLThe straight line of extension cuts off such outer shape, while having and inhaling than breast milk
Receive the outer dimension of the small circle of outer dimension of pad 1.
In turn, thickness direction D of the absorption component 4 in breast milk absorption pad 1THave: being configured in inner surface sheet material 2 and appearance
Between facesheet 3, and can be absorbed, keep through inner surface sheet material 2 breast milk absorber 41.
It should be noted that the outer shape of absorption component is not limited to ad hoc fashion as described above in the present invention
Shape, as long as the shape of absorbent properties as defined in can playing can be using arbitrary outer shape (for example, round, ellipse
Circle, rectangle, fillet it is rectangular etc.).
In above embodiment, absorption component 4 is made of such as lower member: the absorber 41 formed by absorbent material, institute
State the mixture that absorbent material includes the hydrophilic fibre of pulp etc. and the shot-like particle of superabsorbent polymer (SAP)；To cover
Cover the skin surface side S of the absorber 411The mode on surface is come the skin surface side S that configures1Cover sheets 42；Cover absorber 41
Non- skin surface side S2Surface and with from non-skin surface side S2The non-flesh for wrapping up the mode of absorber 41 and cover sheets 42 to configure
Skin surface side S2Cover sheets 43, in turn, in above-mentioned skin surface side S1Cover sheets 42 configured with inhibit breast milk in lipid come
The fatty acid of the generation of the fatty acid in source generates inhibitor.
It should be noted that in the present invention, as long as fatty acid generates the position that inhibitor is configured and does not inhibit of the invention
Effect is just not particularly limited, and fatty acid generates inhibitor other than configuring in the cover sheets of above-mentioned skin surface side, such as
It can be only fitted to the surface of the non-skin surface side of inner surface sheet material or inside, arbitrarily configure non-skin in the inner surface sheet material
The surface or inside of the skin surface side of the intermediate sheet of surface side and/or non-skin surface side, the surface of the skin surface side of absorber or
Any position of internal (that is, the form mixed with absorbent materials such as pulps) etc..Wherein, it is for example above-mentioned to generate inhibitor for fatty acid
When embodiment is configured in like that between inner surface sheet material and absorber, fatty acid can be made to generate inhibitor and more reliably made
For being absorbed into the breast milk before absorber, and so that fatty acid is generated inhibitor and is located at non-skin surface side rather than inner surface sheet material,
To be not easy to be attached to the skin face of wearer since fatty acid generates inhibitor, in turn, due to being not easy via wearer's (lactication
Person) skin face and by baby's oral uptake, therefore also having can make wearer be not easy to feel and generate suppression by above-mentioned fatty acid
The advantages of uneasiness sense such as influence caused by preparation to human body.
In addition, considering from another point of view, fatty acid, which generates inhibitor, can also be configured in the more of composition breast milk absorption pad
It is in a sheet material (for example, above-mentioned inner surface sheet material, intermediate sheet, cover sheets of skin surface side etc.), density highest
Material.When fatty acid generates inhibitor and is configured in such density highest sheet material, fatty acid generates inhibitor and is not easy because wearing
The activity of person, flowing of breast milk etc. and move, therefore can more reliably play the effect that the fatty acid generates inhibitor, and
When fatty acid generation inhibitor is easy discoloration because of oxidation etc., it can be not easy to recognize fat by the sheet material of above-specified high density
Acid generates the discoloration of inhibitor.
Herein, the absorbent material that can be used for absorber does not limit as long as the material that can be absorbed and keep breast milk
In the material of above embodiment, arbitrary absorbent material as known in the art can be used.As such absorbability
Material, such as can enumerate: the cellulose fibres such as the pulps such as fluff pulp, cotton, artificial silk, acetic acid esters；It is copolymerized by sodium acrylate
The shot-like particle that the superabsorbent polymers such as object are formed；With their mixture etc. of any combination.
In addition, skin surface side for being arranged respectively at absorber and for the cover sheets of non-skin surface side, as long as not
Inhibit effect of the invention to be just not particularly limited, can be used for example using coniferous tree bleached kraft pulp as primary raw material and
Formed, base weight 10.0g/m2~15.0g/m2The arbitrary nonwovens such as tissue sheet, Breathable nonwoven, the spun-bonded non-woven fabrics of left and right
Cloth.
It should be noted that outer dimension, the base weight etc. of absorption component entirety do not have as long as the effect not inhibiting of the invention
There is special limitation, the arbitrary outer dimension according to desired absorbent properties, intensity etc., base weight etc. can be used.
[outer packaging sheet]
In above embodiment, when looking down, outer packaging sheet 5 used in breast milk absorption pad 1 has from breast milk absorption pad 1
Longitudinal DLThe edge of side extend to the edge of the other side, simultaneously from lateral DCSide edge from edge to the other side
Outer shape extending, same as the outer shape of the entirety of breast milk absorption pad 1 and outer dimension and outer dimension are (referring to figure
1), and in the thickness direction D of breast milk absorption pad 1T, by the arbitrary adhesive layer (not shown) such as hot melt adhesive and outside
The non-skin surface side S of surficial sheets 32Surface engagement, and from non-skin surface side S2Wrap up the lateral D of outer surface sheet 3CTwo
End, and make lateral DCBoth ends to skin surface side S1It is configured in the state of folding (referring to Fig. 3).The outer packaging sheet 5
Non- skin surface side S is located most closely in breast milk absorption pad 12, in the same manner as outer surface sheet 3, by making to absorb and being maintained at female
Breast milk in newborn absorption pad 1 (in particular, absorption component 4) to the external leakage of breast milk absorption pad 1 and does not determine breast milk absorption pad 1
Shape, liquid-impermeable flat member is formed.
It should be noted that in the present invention, as long as the outer shape of outer packaging sheet can play the work as outer packaging sheet
It, can be using arbitrary outer shape (for example, round, ellipse, fillet rectangular etc.) with being just not particularly limited.
As the liquid-impermeable flat member that can be used as outer packaging sheet, as long as having the rule for the transmission that can prevent breast milk
Fixed liquid-impermeable (further preferably having both the substance of aeration) is just not particularly limited, can be used for example with it is above-mentioned outer
The same non-woven fabrics of surficial sheets, resin sheet etc..It should be noted that outer packaging sheet can be made of 1 flat member, also
It can be made of 2 or more flat members.
It can as long as can be used as the above-mentioned flat member such as outer dimension, base weight of liquid-impermeable flat member of outer packaging sheet
Outer packaging sheet as breast milk absorption pad, which plays a role, to be just not particularly limited, can using corresponding to it is desired it is liquid-impermeable,
The arbitrary outer dimension of intensity etc., base weight etc..
In addition, having such outer packaging sheet not being in breast milk absorption pad of the invention is necessary structure important document, because
When this is such as being alternatively arranged as the case where outer packaging sheet plays a role in above-mentioned outer surface sheet, breast milk absorption pad can not also have
Standby such outer packaging sheet.
Breast milk absorption pad of the invention is not limited to above embodiment etc., can not depart from the purpose of the present invention, master
Proper combination, replacement, change etc. are carried out in the range of purport.It should be noted that in this specification, the sequence of " the 1st ", " the 2nd " etc.
Number is not offered as item sequence, priority, different degree etc. for distinguishing the item for being attached with the ordinal number.
[embodiment]
Following exemplary embodiments and comparative example further illustrate the present invention, but the present invention is not limited only to these
Embodiment.
The breast milk absorption pad for generating inhibitor comprising fatty acid of the invention is designed, various fatty acid is had studied and generates inhibition
Agent is influenced on caused by the activity of lipase contained in practical breast milk.
Embodiment 1
It is added into the actual breast milk provided by the breast milk supplier of lactication phase, with 0.5% additive amount (quality %)
Commercially available product (her rattan of polyphenol in the molecular structure rich in the Epigallo-catechin gallate (EGCG) body with galloyl
Garden Co. Ltd. system, trade name " THEAFLAN 30A ") as fatty acid generation inhibitor, just side is kept the temperature 37 immediately after addition
DEG C side the stipulated time is measured based on the measuring method > of aftermentioned < enzymatic activity amount after lipase enzymatic activity amount (μm ol/
L)。
On the other hand, the breast milk (hereinafter referred to as " un-added breast milk " of inhibitor is generated for being not added with fatty acid.) and
Speech, the enzymatic activity amount for also measuring lipase at the same interval calculate each time interval this is un-added in turn
The ratio (%) of the enzymatic activity amount of embodiment 1 when the enzymatic activity amount of breast milk is set as 100%, using obtained value as lipase
Enzymatic activity reduced rate (%).
The measuring method > of < enzymatic activity amount
(1) preparation of various reagents
The various examinations for preparing matrix solution according to compounding ratio below, reacting stop solution and calibration curve sample liquid
Agent.
(a) matrix solution
Three (hydroxymethyl) aminomethane (Tris) 3mL of 1mol/L are mixed in defined container, are diluted with distilled water
50mmol/L 60 μ L of 2-methyl cellosolve, with the p-nitrophenyl Pork and beans of dimethyl sulfoxide (DMSO) diluted 103mmol/L
Thus matrix solution is made in cool 120 μ L of acid esters, distilled water 8.82mL.
(b) stop solution is reacted
Acetone 15mL and normal heptane 6mL is mixed in defined container, and reaction stop solution is thus made.
(c) calibration curve sample liquid
P-nitrophenol is dissolved in DMSO, the solution (1M solution) of 1mol/L is prepared.It will with the Tris of 0.25mol/L
The 1M solution is diluted to 100 times, and the solution (10mM solution) for preparing 10mmol/L is fitted with the Tris of 0.25mol/L in turn
It preferably dilutes to prepare the sample liquid of calibration curve.
(2) measurement of the enzymatic activity amount (μm ol/L) of lipase
(i) matrix solution 0.5mL is injected separately into the pipe of 2mL.
(ii) test sample is injected into the pipe for the 2mL for being injected with matrix solution (generates suppression comprising breast milk and fatty acid
The breast milk of preparation) 10 μ L, it is incubated in the sink for being heated to 30 DEG C immediately.
(iii) after 15 minutes, the addition reaction stop solution 0.7mL into the pipe of above-mentioned 2mL.
(iv) rotate the pipe of the 2mL added with reaction stop solution using vortex mixer, after so that content liquid is suspended, in turn
It is centrifugated within 2 minutes with 6100 × g of centrifugal force progress.
(v) for the content liquid after centrifuge separation, the water layer of lower part is recycled to each 0.5mL in other 2mL pipes.
(vi) sample liquid of recycling and calibration curve sample liquid are moved in 96 orifice plates with every 200 μ L of hole.
(vii) absorbance of 405nm existing for p-nitrophenol is indicated using the measurement of extinction reader.
It should be noted that the detection limit of the p-nitrophenol measured is equivalent to since lipase makes p-nitrophenyl meat herein
Myristate hydrolyzes and the amount of the p-nitrophenol of generation.
Embodiment 2
The additive amount that fatty acid generates inhibitor is changed to 1.0%, when measuring each similarly to Example 1 in addition to this
Between after lipase enzymatic activity amount, and then find out the value of the enzymatic activity reduced rate of the lipase of embodiment 2.
Embodiment 3~5
Inhibitor is generated as fatty acid to use in the molecular structure rich in the more of the persimmon tannin with galloyl
The commercially available product (Rilis Science Industry Co., Ltd. system, trade name " PANCILCOS-17 ") of phenol, by additive amount
(quality %) is changed to 5%, 10% and 20% respectively, measures the fat of each time respectively similarly to Example 1 in addition to this
The enzymatic activity amount of enzyme, and then find out the value of the enzymatic activity reduced rate of the lipase of embodiment 3~5.
Comparative example 1
Rutin of the inhibitor used as the polyphenol for not having galloyl in the molecular structure is generated as fatty acid,
Additive amount (quality %) is changed to 0.125%, measures the lipase of each time respectively similarly to Example 1 in addition to this
Enzymatic activity amount, and then find out the value of the enzymatic activity reduced rate of the lipase of comparative example 1.
The value of the enzymatic activity reduced rate of the lipase of thus obtained each embodiment and comparative example is shown in table 1 below.
[table 1]
As shown in table 1, it is known that generate inhibitor as fatty acid and used the polyphenol (epi-nutgall with galloyl
Catechin or persimmon tannin) Examples 1 to 5 lipase enzymatic activity reduced rate it is low, lipase can be adequately suppressed
Activity.
On the other hand, it is known that used the comparative example 1 of the polyphenol (rutin) without galloyl, the enzyme activity of lipase
Property reduced rate increase compared with un-added breast milk, do not inhibit not only its activity to promote the activity of lipase instead, therefore
Rutin used in comparative example 1 does not have the effect that inhibitor is generated as fatty acid.
In addition, by Examples 1 and 2 it is found that persimmon tannin has extremely excellent lipase compared with embodiment 3~5
Activity suppression effect.
Claims (14)
1. a kind of breast milk absorption pad, it includes fatty acid to generate inhibitor,
The fatty acid generates the generation of the fatty acid of the Lipid sources in inhibitor inhibition breast milk.
2. breast milk absorption pad according to claim 1, wherein the fatty acid is the short chain fatty acids of carbon number 2~6.
3. breast milk absorption pad according to claim 1 or 2, wherein the fatty acid is selected from by acetic acid, propionic acid, isobutyl
At least one of the group of acid, butyric acid, isovaleric acid, valeric acid, caproic acid composition fatty acid.
4. breast milk absorption pad according to claim 1, wherein it is the work for lipase that the fatty acid, which generates inhibitor,
Property inhibitor.
5. breast milk absorption pad according to claim 4, wherein the lipase is lipoprotein lipase.
6. breast milk absorption pad according to claim 4, wherein the activity inhibitor has galla turcica in the molecular structure
Acyl group.
7. breast milk absorption pad according to claim 4, wherein the activity inhibitor is the polyphenol with galloyl
Class.
8. breast milk absorption pad according to claim 7, wherein the Polyphenols is derived from plant bark, leguminous plant
The polyphenol of beans tea Cassia, tea or persimmon.
9. breast milk absorption pad according to claim 7, also includes discoloration inhibitor,
The discoloration inhibitor inhibits the fatty acid to generate inhibitor discoloration.
10. breast milk absorption pad according to claim 9, wherein the discoloration inhibitor is antioxidant.
11. breast milk absorption pad according to claim 9, wherein the discoloration inhibitor includes to produce as the fatty acid
The water of the solvent of raw inhibitor.
12. breast milk absorption pad according to claim 1, wherein the breast milk absorption pad includes the skin positioned at wearer
The inner surface sheet material of surface side and absorber positioned at the non-skin surface side of the inner surface sheet material,
The fatty acid generates inhibitor and is configured between the inner surface sheet material and the absorber.
13. breast milk absorption pad according to claim 1, wherein the fatty acid generates inhibitor and is configured in composition institute
State the highest sheet material of density in multiple sheet materials of breast milk absorption pad.
14. a kind of fatty acid of breast milk absorption pad generates inhibitor, inhibit the production of the fatty acid of the Lipid sources in breast milk
It is raw.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017-126453 | 2017-06-28 | ||
| JP2017126453A JP6937622B2 (en) | 2017-06-28 | 2017-06-28 | Breast milk pads |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109124879A true CN109124879A (en) | 2019-01-04 |
Family
ID=64802374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810679085.9A Pending CN109124879A (en) | 2017-06-28 | 2018-06-27 | Breast milk absorption pad |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6937622B2 (en) |
| CN (1) | CN109124879A (en) |
| TW (1) | TW201904456A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113599078A (en) * | 2021-08-10 | 2021-11-05 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023087482A (en) * | 2021-12-13 | 2023-06-23 | 花王株式会社 | absorbent article |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113599078A (en) * | 2021-08-10 | 2021-11-05 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
| CN113599078B (en) * | 2021-08-10 | 2022-09-16 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019007116A (en) | 2019-01-17 |
| JP6937622B2 (en) | 2021-09-22 |
| TW201904456A (en) | 2019-02-01 |
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