CN109124666A

CN109124666A - A kind of mthods, systems and devices of determining dose of radiation modulation lines

Info

Publication number: CN109124666A
Application number: CN201810697936.2A
Authority: CN
Inventors: 季敏
Original assignee: Shanghai United Imaging Healthcare Co Ltd
Current assignee: Shanghai United Imaging Healthcare Co Ltd
Priority date: 2018-06-29
Filing date: 2018-06-29
Publication date: 2019-01-04

Abstract

This application provides a kind of mthods, systems and devices of determining dose of radiation modulation lines.This method includes the 3-D image for obtaining object to be scanned；The three-D profile of the object to be scanned is determined based on the 3-D image；Based on the three-D profile of the object to be scanned, corresponding x-ray dose is determined for each slice of the object to be scanned；With the x-ray dose based on each slice, dose-modulated line relevant to the CT scan of the object to be scanned is determined.Using the method, object to be scanned geomery can be more accurately estimated, and then improve the accuracy for determining dose-modulated line.

Description

A kind of mthods, systems and devices of determining dose of radiation modulation lines

Technical field

Present application relates generally to for adjusting radiation in computerized tomography (Computed Tomography, CT) scanning The method and system of dosage, more particularly to dose-modulated (Dose of Modulation, DOM) line is determined during CT scan Method and system.

Background technique

In CT scan, tube current modulation (Tube Current Modulation, TCM), which has become, reduces CT radiation Dosage can keep the effective ways of required picture quality simultaneously.Positioning is as being determined for dose-modulated line, and the dosage Modulation lines may be used as the reference of the tube current of adjustment CT equipment.However, since positioning seems to correspond to scanning constant angle (to lead to Two dimensional image vertically downward often), therefore can not accurately estimate the 3D shape or size of object to be scanned, and then cause to be based on Positioning may inaccuracy as the dose-modulated line determined.Therefore, it is necessary to a kind of more reliable dose-modulated lines to determine method, can be with More accurately estimate object to be scanned geomery, and then improves the accuracy that CT system determines dose-modulated line.

Summary of the invention

In view of the above-mentioned problems, being solved the present invention discloses a kind of mthods, systems and devices of determining dose of radiation modulation lines Above-mentioned problems of the prior art.

To achieve the above object of the invention, technical solution provided by the invention is as follows:

The first aspect of the application provides a kind of method of determining dose of radiation modulation lines, this method comprises: obtaining wait sweep Retouch the 3-D image of object；The three-D profile of the object to be scanned is determined based on the 3-D image；Based on described to be scanned The three-D profile of object determines corresponding x-ray dose for each slice of the object to be scanned；Described in being based on The x-ray dose of each slice determines dose-modulated line relevant to the CT of object to be scanned scanning.

In some embodiments, the three-D profile that the object to be scanned is determined based on the 3-D image, comprising: Determine initial three-D profile；At least one parameter of the initial three-D profile is determined based on the 3-D image；With based on institute At least one parameter is stated, the initial three-D profile is updated.

In some embodiments, the three-D profile based on the object to be scanned is the every of the object to be scanned A slice determines corresponding x-ray dose, comprising: the three-D profile based on the object to be scanned determines at least one The slice；Determine the size of at least one slice；Mapping table is obtained, the mapping table includes X-ray agent Corresponding relationship between amount and slice size；With the size based at least one slice, the mapping is searched for Table is with the corresponding x-ray dose of determination.

In some embodiments, the method for determining dose of radiation modulation lines includes adjusting CT based on the dose-modulated line The tube current in equipment radioactive scanning source.

In some embodiments, the 3-D image of the object to be scanned is based on stereovision technique, structured light techniques Or flying time technology determines.

In some embodiments, the three-D profile of the object to be scanned is cylindrical body, Elliptic Cylinder or cuboid.

In some embodiments, the object to be scanned includes head, chest, neck, abdomen, pelvis or the leg of patient At least one of.

In some embodiments, the method for the determination dose of radiation modulation lines further include: obtain the object to be scanned Position picture；It is described relevant to the CT scan of the object to be scanned with being determined based on the positioning picture and the 3-D image Dose-modulated line.

The second aspect of the application provides a kind of system of determining dose of radiation modulation lines, which includes: acquiring unit, It is configured as obtaining the 3-D image of object to be scanned；Three-D profile determination unit is configured as true based on the 3-D image The three-D profile of the fixed object to be scanned；It with dose-modulated line generation unit, is configured as: based on the object to be scanned Three-D profile determines corresponding x-ray dose for each slice of the object to be scanned；Be based on each slice X-ray dose, determine relevant to the CT scan of object to be scanned dose-modulated line.

The third aspect of the application provides a kind of device of determining dose of radiation modulation lines.The device include storage medium with And at least one processor；The storage medium includes computer instruction；It is described for executing at least one described processor At least partly instruction in computer instruction is to realize the operation in above method.

Detailed description of the invention

The application will be described in conjunction with the embodiments.These exemplary embodiments will be combined and will be described in detail with reference to figure.This A little embodiments are non-limiting exemplary embodiment, wherein identical appended drawing reference indicates similar in multiple views of attached drawing Structure, and wherein:

Fig. 1 is a kind of schematic diagram of exemplary imaging system according to shown in some embodiments of the application；

Fig. 2 is a kind of calculating example hardware of equipment and showing for component software according to shown in some embodiments of the application It is intended to；

Fig. 3 is the exemplary shifting that particular system disclosed in this application can be achieved according to shown in some embodiments of the application The hardware of dynamic equipment and/or the schematic diagram of software component；

Fig. 4 is a kind of schematic block diagram of exemplary processing devices according to shown in some embodiments of the application；

Fig. 5 is according to shown in some embodiments of the application for determining a kind of exemplary process diagram of dose-modulated line；

Fig. 6 is the schematic block diagram of the processing module according to shown in the application some embodiments；

Fig. 7 is to be based on three-dimensional (Three-Dimensional, 3D) image according to shown in some embodiments of the application and determine A kind of exemplary process diagram of the position as determining dose-modulated line；

Fig. 8-A and Fig. 8-B is according to shown in some embodiments of the application for training dose-modulated line to generate model A kind of exemplary process diagram；

Fig. 9 is a kind of structural schematic diagram that the dose-modulated line according to shown in the application some embodiments generates model；

Figure 10 is the schematic block diagram of the processing module according to shown in the application some embodiments；

Figure 11 is to determine that one kind of dose-modulated line is exemplary based on 3D rendering according to shown in some embodiments of the application Flow chart；

Figure 12 is the schematic block diagram of the processing module according to shown in the application some embodiments；

Figure 13 is based on positioning according to shown in some embodiments of the application as the one kind for determining dose-modulated line is exemplary Flow chart；

Figure 14 is according to shown in some embodiments of the application for determining a kind of exemplary stream of region dose-modulated line Cheng Tu；And

Figure 15 is the schematic diagram of exemplary human and exemplary dose modulation lines according to shown in the application some embodiments.

Specific embodiment

It is described below the technical solution in order to enable those skilled in the art to implement the application, and upper and lower It is provided in text and specifically applies and its require in the application.For those of ordinary skill in the art, it is clear that can be to this Apply for that various modification can be adapted for the embodiment disclosed, and without departing substantially from spirit and scope, institute in the application The rule of definition can be adapted for other embodiments and application scenarios.Therefore, the application is not limited to disclosed implementation Example, and should be given and the consistent widest scope of claim.

It should be appreciated that term " system ", " engine ", " unit ", " module " and/or " block " used herein is with ascending order area Divide different components, the component, assembly unit, a kind of method of section or component of different stage.However, it is possible to use other can achieve Identical purpose expression replaces terms above.

In general, " module ", " unit " and/or " block " in the application refer to being stored in hardware, patrolling in firmware Volume or one group of software instruction.Module described herein, unit or block can be implemented by software and/or hardware, can also be deposited It is stored in any non-transitory computer-readable medium or other storage equipment.In some embodiments, software module/mono- Member/block can be compiled and be linked in executable program.Here software module can to itself or other module/units/ The information of block transmitting responds, and/or can respond when detecting certain events or interrupting.It is configured to Calculating the software module/unit/block executed on equipment (for example, processor 220 as shown in Figure 2) can be by computer-readable Jie Matter provides, and computer-readable medium here can be CD, optical digital disk, flash disk, disk or any other tangible medium, As number downloading (and can initially with compression or installable format storage, need to install before execution, decompression or Decryption).Here software code can be stored in the storage equipment for the calculating equipment for executing operation by part or all of, And it applies among the operation for calculating equipment.Software instruction can be embedded in firmware, such as erasable programmable read-only memory (Erasable Programmable Read Only Memory,EPROM).Obviously, hardware module/unit/block includes connection Logic unit together, such as door, trigger, and/or be comprised in programmable unit, for example, programmable gate array or Processor.Module/unit/block described herein or computing device functionality may be embodied as software module/unit/block, but can To be indicated with hardware or firmware.Under normal circumstances, module/unit/block mentioned here is logic module/unit/block, these moulds Block/unit/block can be combined with other module/unit/blocks, or be divided into submodule/subelement/sub-block, and Physical organization or storage regardless of them.The description can be applied to system, engine or part of it.

Term used in this application does not limit the scope of the application only for describing certain exemplary embodiments.It removes Non- context clearly prompts exceptional situation, " one " used herein, "one", the words such as "an" and "the" not refer in particular to list Number, may also comprise plural number.It is also understood that the terms "include", "comprise" used herein only prompt there are the feature, Entirety, step, operation, component and/or component, but be not precluded presence or add at least one other feature, entirety, step, The case where operation, component, component and/or combination thereof.

After considering the description content as the attached drawing of the application a part, the feature and feature of the application and operation Method, the function of the coherent element of structure, the combination of each section, manufacture economy become apparent.However, it should be clear that Ground understands that the purpose that attached drawing is merely to illustrate and describes is not intended to limit scope of the present application.It should be understood that attached drawing It is not necessarily drawn to scale.

Used herein flow chart illustrates operation performed by system according to an embodiment of the present application.It should manage Solution, operation in flow chart not necessarily execute in sequence.On the contrary, various steps can be handled according to inverted order or simultaneously.This Outside, at least one other operation can be added in flow chart.At least one operation can also be deleted from flow chart.

This application involves the method and systems for determining dose-modulated line.In some embodiments, this method be related to based on to The image of sweep object determines dose-modulated line.In some embodiments, the shape as can be used for estimating object to be scanned is positioned Shape size (such as 3D profile).For example, the geomery of object can be estimated according to the attenuation data of positioning object as in.So It and seem two dimension (Two-Dimensional, the 2D) figure for corresponding to scanning constant angle (usually vertically downward) due to positioning Picture, therefore can not accurately estimate the shape or size of object to be scanned, especially in transverse direction and inclined direction.In order to solve this A problem, 3D rendering can be used to generate more accurate body form or 3D profile.Can based on 3D profile attribute (such as Thickness, width) determine dose of radiation on object to be scanned every slice (every correspond to specific scanning angle).According to determination Dose of radiation determine dose-modulated line.

In some embodiments, this method is related to based on positioning as determining dose-modulated line.For example, an object to be scanned Positioning picture can be divided at least one area-of-interest.For each of at least one area-of-interest, identification One reference location picture.Region dose-modulated line is determined for each reference location picture, and by region dose-modulated line group symphysis At the dose-modulated line of entire object to be scanned.

In some embodiments, this method is related to determining dose-modulated based on the 3D rendering of positioning picture and object to be scanned Line.For example, model can be generated to determine the dose-modulated line of object to be scanned by obtaining dose-modulated line.The dose-modulated Line is generated model and can be obtained based on training dataset training, which includes multiple samples of multiple objects to be scanned CT image, multiple samples positioning picture and multiple 3D renderings.Using the positioning picture of object to be scanned and 3D rendering as trained dose The input that modulation lines generate model is measured, that is, produces personalised dosage modulation lines.

Fig. 1 is a kind of schematic diagram of exemplary imaging system according to shown in some embodiments of the application.In some implementations In example, imaging system 100 can scan object to be scanned and obtain corresponding scan data.Imaging system 100 can be based on sweeping It retouches data and generates image.Imaging system 100 can be with pre-treatment scan data or the image of generation.Scan data or the image of generation Pretreatment include noise reduction, smooth, correction etc., or any combination thereof.

In some embodiments, imaging system 100 can be medical image system.Medical image system can be single mode Imaging system or multi-mode imaging system.Single mode imaging system include PET (Positron Emission Tomography, Positron emission tomography) equipment, SPECT (Single Photon Emission Computed Tomography, monochromatic light Son transmitting computer tomography) equipment, CT (Computed Tomography, computer tomography) equipment, MRI (Digital Radiography, digital radial shine by (Magnetic Resonance Imaging, magnetic resonance imaging) equipment, DR Phase) equipment etc..Multi-mode imaging system includes PET-CT equipment, PET-MRI equipment, SPECT-MRI equipment etc..

As shown in the figure 1, imaging system 100 includes scanning device 110, network 120, at least one terminal 130, processing equipment 140 and memory 150.

Scanning device 110 includes rack 111,3D depth camera 112, radioactive scanning source 113, detector 114 and work Platform 115.Three Cartesian coordinates are shown in Fig. 1.Workbench 115 can support an object to be scanned (such as patient).Z Axis (also referred to as Z-direction) corresponds to the long axis direction of object to be scanned.X-Y plane (also referred to as cross section or axial plane) is right Plane of the Ying Yu perpendicular to Z axis.During CT scan, radioactive scanning source 113 and detector 114 can be protected on an x-y plane It is constant while rotating to hold relative position.

Rack 111 supports 3D depth camera 112, radioactive scanning source 113 and detector 114.In some embodiments, work Making platform 115 can move along Z axis.The movement speed of workbench 115 can be adjusted according to sweep time, scanning area etc. It is whole.

3D depth camera 112 can shoot three-dimensional (3D) image (also referred to as depth image) of object to be scanned.3D is deep Spending camera 112 can be from multiple angle shot 3D rendering, including but not limited to from front, top, side etc..In some embodiments In, 3D depth camera can be based on stereovision technique, structured light techniques, flight time (Time-of-Flight, ToF) skill Art etc., or any combination thereof generate 3D rendering.In some embodiments, the 3D of object to be scanned can be estimated based on 3D rendering Profile.

Radioactive scanning source 113 can emit radioactive ray to object to be scanned.Radioactive ray include corpuscular rays, Photon beam Deng.Corpuscular rays include neutron, proton, electronics, μ medium, heavy ion etc., or any combination thereof.Photon beam include X-ray, Gamma-rays, alpha ray, β ray, ultraviolet light, laser etc., or any combination thereof.In some embodiments, it during CT scan, puts Penetrating property scanning source 113 can rotate in X-Y plane.In some embodiments, during positioning scanning, radioactive scanning source 113 are in resting position.

Detector 114 can detecte radioactive ray.The radioactive ray at least partly detected can be by penetrating scanned object. It is generated in response to the radioactive ray detected and reads data (also referred to as scan data).In some embodiments, detector 114 wraps Include scintillation detector (such as cesium iodide detector), gas detector, round detector, square detector, arcuate detector Deng, or any combination thereof.In some embodiments, detector can be single row detector or multi-detector.

Network 120 may include the network that can facilitate information exchange and/or data exchange in imaging system 100.? In some embodiments, at least one component of imaging system 100 (such as scanner 110, terminal 130, processing equipment 140, storage Device 150, image acquisition equipment 160 etc.) letter can be carried out by least one other component of network 120 and imaging system 100 Message communication and/or data communication.For example, processing equipment 140 can obtain image data from scanner 110 by network 120. In another example processing equipment 140 can obtain user instruction from terminal 130 by network 120.Network 120 can be and/or including Public network (such as internet), dedicated network (such as local area network (Local Area Network, LAN), wide area network (Wide Area Network, WAN) etc.), cable network (such as Ethernet), wireless network (such as 802.11 networks, Wi-Fi network), cellular network (such as long term evolution (Long Term Evolution, LTE) network), frame-relay network, Virtual Private Network (Virtual Private Network, VPN), satellite network, telephone network, router, hub, interchanger, in server computer etc. One or more of combinations.For example, network 120 may include cable system, it is cable network, fiber optic network, telecommunication network, interior Networking, WLAN (Wireless Local Area Network, WLAN), Metropolitan Area Network (MAN) (Metropolitan Area Network, MAN), Public Switched Telephony Network (Public Telephone Switched Network PSTN), bluetooth, The combination of one or more of Zigbee network, near-field communication (Near Field Communication, NFC) network etc.. In some embodiments, network 120 may include at least one network access point.For example, network 120 may include it is wired and/ Or wireless network access point such as base station and/or internet exchange point.At least one component of imaging system 100 can be by described Base station and/or internet exchange point are connect with network 120, to realize the exchange of data and/or information.

Terminal 130 may include one of mobile device 130-1, tablet computer 130-2, laptop computer 130-3 etc. or Several combinations.In some embodiments, mobile device 130-1 may include smart home device, wearable device, movement set The combination of one or more of standby, virtual reality device, augmented reality equipment etc..In some embodiments, the intelligent family Occupying equipment may include intelligent lighting equipment, control equipment, intelligent monitoring device, smart television, the intelligence of intelligent electronic device The combination of one or more of video camera, intercom etc..In some embodiments, the wearable device may include hand The combination of one or more of ring, footgear, glasses, the helmet, wrist-watch, clothing, knapsack, smart accessories etc..In some embodiments In, the mobile device may include cell phone, personal digital assistant (Personal Digital Assistance, PDA), game station, navigation equipment, point of sale (Point of Sale, POS) equipment, laptop computer, tablet computer, desktop The combination of one or more of brain etc..In some embodiments, the virtual reality device and/or the augmented reality equipment It may include virtual implementing helmet, virtual reality glasses, virtual reality eyeshade, the augmented reality helmet, augmented reality glasses, enhancing The combination of one or more of real eyeshade etc..For example, the virtual reality device and/or the augmented reality equipment can be with Including Google glasses, Oculus Rift, Hololens, Gear VR etc..In some embodiments, terminal 130 can be place Manage a part of equipment 140.

Processing equipment 140 can handle the data obtained from scanning device 110, terminal 130 and/or memory 150 and/ Or information.For example, processing equipment 140 can handle image data (for example, 3D rendering and/or positioning picture) and determine dose-modulated Line, the dose-modulated line may be used as adjusting the reference of the tube current in radioactive scanning source 113.In some embodiments, it handles Equipment 140 can be individual server or server group.Server group can be centralization, be also possible to distributed.? In some embodiments, processing equipment 140 can be local or remote.For example, processing equipment 140 can pass through network 120 Access is stored in scanning device 110, terminal 130 and/or information and/or data in memory 150.In another example processing equipment 140 can be directly connected to scanning device 110, terminal 130 and/or memory 150 to access the information and/or number of storage According to.In some embodiments, processing equipment 140 can be realized in cloud platform.Only as an example, cloud platform include private clound, Public cloud, mixed cloud, community cloud, distributed cloud, internal cloud, multiple cloud etc., or any combination thereof.In some embodiments, locate Reason equipment 140 can be as including that the calculating equipment 200 of component described at least one Fig. 2 is realized.

Memory 150 can store data, instruction and/or other information.In some embodiments, memory 150 can be with Store the data obtained from terminal 130 and/or processing equipment 140.In some embodiments, memory 150 can store number According to and/or instruction, the data and/or instruction can be used or be executed by processing equipment 140, described to realize in the present invention Illustrative methods.In some embodiments, memory 150 may include mass storage, removable memory, volatibility The combination of one or more of read-write memory, read-only memory (Read-Only Memory, ROM) etc..The large capacity Memory may include disk, CD, solid state hard disk etc..The removable memory may include flash drive, floppy disk, light Disk, storage card, compact disk, tape etc..The volatile read-write memory may include random access memory (Random Access Memory,RAM).The RAM includes dynamic RAM (Dynamic RAM, DRAM), Double Data Rate synchronous dynamic random Memory (Double Date Rate Synchronous Dynamic RAM, DDR SDRAM), Static RAM (Static RAM, SRAM), thyristor random access memory (Thyristor RAM, T-RAM), zero capacitance random access memory (Zero-capacitor RAM, Z-RAM) etc..The ROM may include mask ROM (Mask ROM, MROM), can Program read-only memory (Programmable ROM, PROM), erasable programmable random access memory (Erasable Programmable ROM, EPROM), electrically erasable programmable read-only memory (Electrically Erasable Programmable ROM, EEPROM), CD (Compact Disk ROM, CD-ROM), digital versatile disc read-only memory Deng.In some embodiments, the function of memory 150 can be realized in cloud platform.For example, the cloud platform may include private There is the combination of one or more of cloud, public cloud, mixed cloud, community cloud, distributed cloud, interconnection cloud, cloudy etc..

In some embodiments, memory 150 can be connect with network 120, thus at least one in imaging system 100 A other components (such as processing equipment 140, terminal 130) are communicated.At least one component in imaging system 100 can be with The data or instruction that memory 150 stores are obtained by network 120.In some embodiments, memory 150 can directly at As at least one of system 100 other components (such as processing equipment 140, terminal 130) are attached or communicate.In some realities It applies in example, memory 150 can be a part of processing equipment 140.

Fig. 2 is a kind of calculating example hardware of equipment and showing for component software according to shown in some embodiments of the application It is intended to.

Calculating equipment 200 can be general purpose computer or special purpose computer, the two may be used to implement the application at As system.In some embodiments, processing equipment 140 can be set via its hardware, software program, firmware or combinations thereof in calculating It is realized on standby 200.For example, three-dimensional (3D) image (also referred to as depth image) and/or positioning picture can be obtained by calculating equipment 200, And based on the 3D rendering and/or positioning as generating dosage modulation lines.Calculating equipment 200 is also based on the adjusting of dose-modulated line and puts The tube current in penetrating property scanning source 113.

For example, calculating equipment 200 includes the port communication (COM) 250 for being connected with network and data being promoted to transmit.Meter Calculating equipment 200 further includes the processor 220 of at least one processor form for executing program instructions (for example, central processing Unit (Central Processing Unit, CPU)).Illustrative computer platform includes internal communication bus 210, difference The program storage and data storage of form, for example, disk 270 and read-only memory (ROM) 230 or random access memory (RAM) 240, for storing the various data files by computer disposal and/or transmission.Illustrative computer platform Also include be stored in the non-transitory storage medium of ROM 230, RAM 240 and/or other forms can be by processor 220 The program instruction of execution.Methods disclosed herein and/or process can be used as program instruction to implement.Calculating equipment further includes Input-output apparatus 260, for supporting computer and other assemblies such as family interface 280 to carry out input/output.Calculate equipment 200 can also receive program and data by network communication.

Calculate equipment 200 further include hard disk controller communicate with hard disk, the keyboard controller communicated with keyboard, and serially The serial interface controller of peripheral communications, the parallel interface controller communicated with concurrent peripheral are communicated with display Display controller etc., or any combination thereof.

Only a processor is only described as an example, calculating in equipment 200.It is to be noted, however, that in the application Calculating equipment 200 can also include multiple processors.Therefore, such as the operation described in this application executed by a processor And/or method and step can also be executed jointly or respectively by multiple processors.For example, in this application, if calculating equipment 200 Processor need to be implemented operation A and operation B, it can be understood as operation A and operate B can be by two of calculating equipment 200 not With processor it is common or respectively execute (for example, first processor executes operation A, second processor executes operation B or the One processor and second processor execute operation A and B jointly).

Fig. 3 is the exemplary shifting that particular system disclosed in this application can be achieved according to shown in some embodiments of the application The hardware of dynamic equipment 300 and/or the schematic diagram of software component.The function of terminal 130 may be implemented in the mobile device 300. As shown in figure 3, mobile device 300 includes communications platform 310, display 320, graphics processing unit (Graphic Processing Unit, GPU) 330, central processing unit (Central Processing Unit, CPU) 340, I/O 350, Memory 360 and memory 390.In some embodiments, any other suitable component, including but not limited to system bus or control Device (not indicating) processed, may also comprise in mobile device 300.In some embodiments, Mobile operating system 370 is (for example, iOS System, Android system, Windows system, Phone system etc.) and at least one application program 380 can be from memory 390 are loaded into memory 360, to be executed by CPU 340.It include that browser or any other suitable movement are answered using 380 With software, for receiving and rendering information related with image procossing or other information from processing equipment 140.User and letter The interaction of breath stream can be realized by I/O 350, and be provided to processing equipment 140 and/or imaging system by network 120 100 other assemblies.

In the present invention, computer hardware platforms may be used as the hardware platform of at least one element, implement various modules, Unit and their function.Computer with user interface can be used as PC (Personal Computer, PC), other work stations or terminal device, properly programmed computer can also be used as server.

Fig. 4 is a kind of schematic block diagram of exemplary processing devices according to shown in some embodiments of the application.Processing is set Standby 140 include obtaining module 410, processing module 420 and memory module 430.

Obtain module 410 be configured as obtain object to be scanned three-dimensional (3D) image (also referred to as depth image) and/ Or positioning picture.The object to be scanned can be patient or patient tissue or organ (such as head, neck, chest, abdomen, Pelvis etc.).

In some embodiments, obtaining module 410 can be from storage equipment (such as memory 150, disk 270, memory 360, memory module 430, the storage equipment (or referred to as External memory equipment) outside imaging system 100) obtain it is to be scanned right The 3D rendering of elephant.In some embodiments, obtaining module 410 can obtain from 3D depth camera (such as 3D depth camera 112) The 3D rendering of object to be scanned.In some embodiments, 3D depth camera can be from the 3D of multiple angle shot objects to be scanned Image, including but not limited to from front, top, side etc..3D depth camera can be based on stereovision technique, structured light skill Art, flight time (Time-of-Flight, ToF) technology etc., or any combination thereof generate 3D rendering.In some embodiments In, 3D rendering can be sent to processing module 420 to handle by obtaining module 410.

In some embodiments, obtaining module 410 can be from storage equipment (such as memory 150, disk 270, memory 360, memory module 430, External memory equipment) obtain object to be scanned positioning picture.In some embodiments, module is obtained 410 can obtain positioning as data from detector 114, and by the positioning as data are transferred to processing module 420.Processing module 420, which can carry out a step processing (such as reconstruction) positioning, generates positioning picture as data.In some embodiments, positioning is as can be with It is associated with positioning scanning.When radioactive scanning source 113 is in resting position and workbench 115 is moved along Z axis (as schemed Shown in 1), positioning scanning can be executed by scanning device 110.For example, if radioactive scanning source 113 is located on object to be scanned Side then can obtain anterior-posterior (anterior-posterior, AP) in positioning scanning and position picture.In another example if radioactivity Scanning source 113 is located at the side of object, then can obtain lateral register picture in positioning scanning.In some embodiments, it obtains The available AP of module 410 positioning picture, lateral register picture or both.Then, the positioning picture can be transmitted to by obtaining module 410 Processing module is to be handled.

Processing module 420 is configured as generating dose-modulated line based on 3D rendering and/or positioning picture.In some embodiments In, processing module 420 can generate dose-modulated line as the two based on 3D rendering and positioning.As shown in Fig. 7 and its description.? In some embodiments, processing module 420 can be based only upon 3D rendering and generate dosage modulation lines.As shown in Figure 11 and its description.? In some embodiments, processing module 420 can be based only upon positioning picture to generate dose-modulated line.As shown in Figure 13 and its description.

In some embodiments, dose-modulated line or region dose-modulated line can be continuous curve, embody radiation agent Amount is at any time or the consecutive variations of angle.In some embodiments, dose-modulated line or region dose-modulated line can be discrete , including at least one discrete point, each discrete point is corresponding to specific time or the dose of radiation of angle.In some embodiments In, dose-modulated line or region dose-modulated line can be the combination of at least one section zonal cooling curve, or at least one section segmentation The combination of full curve and at least one discrete point.When carrying out CT scan to object to be scanned, dose-modulated line or region agent The data point of amount modulation lines can characterize adjusting (also referred to as dose of radiation modulation, dose-modulated or the tube current tune of dose of radiation System) degree.Dose of radiation modulation can be by adjusting radioactive scanning source 113 based on dose-modulated line during CT scan Tube current is realized.For example, during CT scan, when workbench 115 is moved along Z axis, radioactive scanning source 113 It can be rotated in X-Y plane.Dose of radiation modulation can be flat in X-Y by being based on dose-modulated line during CT scan It face and is realized along the tube current that Z axis adjusts radioactive scanning source 113.

In some embodiments, dose-modulated line can show the relationship between sweep time between dose of radiation and time.Spoke Penetrating dosage can be associated with the parameter in scanning device 110, such as tube current-time product, tube current, tube voltage, pitch, has Imitate dosage, absorbed dose etc..In this application, tube current-time product refers to the x-ray tube current (example in radioactive scanning source 113 Such as, as unit of milliampere) and CT scanner it is every rotation one week time for exposure (for example, in seconds) product.In this Shen Please in, tube voltage refers to the peak energy (for example, as unit of kilovolt) of the x-ray photon in X-ray energy spectrum.In the application In, pitch refer to the stage translation that works in spiral CT (by centimetre as unit of, 360 ° of racks rotation table feed amount) with Z-direction on Total nominal collimating X-ray beam width ratio.In this application, absorbed dose refers to the specific of in CT scan object to be scanned The radiation energy that region absorbs.In this application, effective dose embodies the radiation energy pair that object to be scanned absorbs in CT scan The long-term influence of object to be scanned.Time point corresponds to specific scanning angle (such as radioactive scanning source 113 on X-Y plane Specific configuration or position).During the scanning process, time point also corresponds to the specific of object to be scanned under respective scanned angle and cuts Piece.

In some embodiments, object to be scanned can be divided into multiple slices along Z axis.Each slice is parallel to each other. The thickness of each slice can change according at least one different sweep parameter.The thickness of slice can be by operator's (example Such as nurse, radiologist) or the setting of imaging system 100.In some embodiments, radioactive scanning source 113 can around to Sweep object is rotated by 360 °, to obtain CT image data corresponding with each slice of object to be scanned.When 115 edge of workbench Z axis it is mobile and when radioactive scanning source 113 is rotated around object, the CT image data of available multiple slices.

Memory module 430 is configured as storage 3D rendering, positioning picture, dose-modulated line etc., or any combination thereof.Some In embodiment, memory module 430 can store at least one program and/or instruction, at least one described program and/or instruction by The processor of processing equipment 140 executes, to realize illustrative methods described in the present invention.For example, memory module 430 can be with The program and/or instruction that storage is executed by the processor of processing equipment 140, to obtain the 3D rendering of object to be scanned and/or determine Position picture, based on the 3D rendering and/or positioning as generating dosage modulation lines, and/or the base when executing CT scan to object to be scanned Tube current in dose-modulated line adjustment radioactive scanning source 113.

It should be noted that above description is only exemplary, the application can not be limited in cited is to implement Within the scope of example.For those of ordinary skill in the art, various repair can be made according to the description of the present application Just or change.However, these modifications and variations are without departing from scope of the present application.For example, obtaining module 410 and processing module 420 can respectively include independent storage unit.

Fig. 5 is according to shown in some embodiments of the application for determining a kind of exemplary process diagram of dose-modulated line.

In 510, the 3D rendering (also referred to as depth image) of the available object to be scanned of module 410 is obtained.It is described to Sweep object can be the tissue or organ (such as head, neck, chest, abdomen, pelvis etc.) of patient or patient.Obtain mould Block 410 can be from 3D depth camera (for example, 3D depth camera 112) or storage equipment (for example, memory 150, disk 270, interior Deposit 360, memory module 430, External memory equipment) obtain object to be scanned 3D rendering.In some embodiments, 3D depth phase Machine can be from the 3D rendering of multiple angle shot objects to be scanned, including but not limited to from front, top, side etc..3D depth Camera can based on stereovision technique, structured light techniques, flight time (Time-of-Flight, ToF) technology etc. or its Any combination generates 3D rendering.

In some embodiments, 3D rendering includes pixel.Some pixel in 3D rendering contain on object to be scanned The relevant information of some corresponding points.For example, some pixel in 3D rendering contain with from 3D depth camera to be scanned right As the relevant information of the distance of some upper corresponding points, the gray value of the corresponding points or color etc., or any combination thereof.3D rendering The range information of middle pixel can be used for determining the 3D profile of object to be scanned.In some embodiments, 3D profile includes cylinder Body, Elliptic Cylinder, cuboid etc..3D profile includes the surface texture or shaped size information of object to be scanned, such as width, thickness Degree etc., or any combination thereof.

In some embodiments, the radiation agent when 3D profile of object to be scanned is related to object to be scanned execution CT scan Amount modulation.For example, for two patients with different 3D profiles, in order to obtain quality it is essentially identical for diagnostic purposes Two CT images, during CT scan, the patient with larger 3D profile may need than the patient with smaller 3D profile more High dose of radiation (or higher tube current).

In some embodiments, the difference before executing CT scan to object to be scanned, during can determining and scanning Time point (or scanning angle) corresponding dose of radiation.Based on 3D rendering described herein, it can determine and modulate and sweep The corresponding dose of radiation of different time points during retouching.

In 520, the positioning picture that module 410 obtains object to be scanned is obtained.Obtaining module 410 can be from storage equipment The positioning of (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) acquisition object to be scanned Picture.Positioning is as can be AP positioning picture or lateral register picture.In some embodiments, in operation 520, obtaining module 410 can To obtain the AP positioning picture and lateral register picture of object to be scanned.

In some embodiments, positioning is as the attenuation data comprising object to be scanned.Attenuation data of the positioning as in is available In the attenuation characteristic of estimation object to be scanned.When the attenuation characteristic of object to be scanned is related to object to be scanned execution CT scan Dose of radiation modulation.For example, in the decaying system with higher of sclerous tissues' (for example, bone) that positioning is shown as brighter areas as in Number, and the soft tissue (for example, lung) than being shown as darker area as in positioning needs higher dose of radiation (to correspond to Higher tube current).

In some embodiments, positioning is as corresponding to scan protocols.The anatomic region example of scan protocols and object to be scanned Such as head, neck, chest correlation.For example, scan protocols may include that head scanning agreement, neck scan protocols, chest are swept Retouch agreement etc..In some embodiments, scan protocols include sweep parameter, such as voltage, the pipe electricity in radioactive scanning source 113 Stream-time product, beam width, gantry rotation times, reconstruct core etc., or any combination thereof.In some embodiments, scan protocols Comprising dose of radiation parameter and whether using the dose-modulated line parameter adjust the dose of radiation in scanning process.Different Scan protocols can have identical or different sweep parameter.In some embodiments, processing module 420 can be based on positioning picture The attenuation characteristic of middle reflection and the dose of radiation that CT scan is determined corresponding to the scan protocols of locating plate.

In some embodiments, the geomery as can be used for estimating object to be scanned is positioned.For example, AP positioning is as available In the width (also referred to as X-coordinate value) of each slice of estimation object to be scanned.In another example lateral register picture can be used to estimate Count the thickness (also referred to as Y-coordinate value) of each slice of object to be scanned.

In some embodiments, the difference before executing CT scan to object to be scanned, during can determining and scanning Time point (or scanning angle) corresponding dose of radiation.Dose of radiation corresponding to different time points during scanning can be based on Positioning described herein is as determining and modulating.

In 530, processing module 420 can be based on 3D rendering and/or positioning as generating dosage modulation lines.In some implementations In example, processing module 420 can generate dosage modulation lines based on both 3D rendering and positioning picture and (for example, with reference to Fig. 7 and its retouch It states).In some embodiments, processing module 420 can be based only upon 3D image generate dosage modulation lines (for example, with reference to Figure 11 and It is described).In some embodiments, processing module 420 can be based only upon positioning as generating dosage modulation lines (for example, with reference to figure 13 and its description).

When executing CT scan to object to be scanned, dose-modulated line can characterize adjusting (the also referred to as spoke of dose of radiation Penetrate dose-modulated, dose-modulated or tube current modulation) degree.Dose of radiation modulation can be by being based on during CT scan Dose-modulated line adjusts the tube current in radioactive scanning source 113 to realize.For example, during CT scan, when workbench 115 When moving along Z axis, radioactive scanning source 113 can rotate in X-Y plane.Dose of radiation modulation can be by spiral It is realized during CT scan based on dose-modulated line in X-Y plane and along the tube current in Z axis adjusting radioactive scanning source 113.

In some embodiments, dose-modulated line can show the relationship between sweep time between dose of radiation and time.Spoke Penetrating dosage can be associated with the parameter in scanning device 110, such as tube current-time product, tube current, tube voltage, pitch, has Imitate dosage, absorbed dose etc..Sweep time or time point correspond to specific scanning angle (for example, the radioactivity in X-Y plane The specific configuration in scanning source 113 or position).Time point during scanning may correspond in respective scanned angle wait sweep Retouch the particular slice of object.

It should be noted that foregoing description is provided merely for illustrative purpose, it is no intended to limit scope of the present application. For those of ordinary skill in the art, various amendments or change can be made according to the description of the present application.So And these modifications and variations are without departing from scope of the present application.For example, operation 510 can execute after operation 520, or Operation 510 and operation 520 are performed simultaneously.In another example can be omitted operation 510 or operation 520 in process 500.For another example mistake Journey 500 includes based on the operation for generating 3D rendering and/or positioning picture as relevant image data to 3D rendering and/or positioning.

Fig. 6 is the schematic block diagram of the processing module according to shown in the application some embodiments.Processing module 420 includes Acquiring unit 610, training unit 620 and dose-modulated line generation unit 630.

Acquiring unit 610 is configured as obtaining three-dimensional (3D) image (also referred to as depth image) of object to be scanned and determine Position picture.Acquiring unit 610 can be from storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, outer Portion stores equipment) it obtains the 3D rendering of object to be scanned and positions picture..

In some embodiments, the attenuation data as including object to be scanned is positioned.Attenuation data of the positioning as in is available In the attenuation characteristic of estimation object to be scanned.The attenuation characteristic of object to be scanned is related to when executing CT scan to object to be scanned Dose of radiation modulation.For example, the sclerous tissues' (for example, bone) for being shown as brighter areas in positioning picture can during CT scan Energy attenuation coefficient with higher, and soft tissue (for example, lung) needs than being shown as darker area as in positioning are higher Dose of radiation (correspond to higher tube current).

In some embodiments, the difference before executing CT scan to object to be scanned, during can determining and scanning Time point (or scanning angle) corresponding dose of radiation.Based on 3D rendering described herein and positioning picture, can determine and Modulate dose of radiation corresponding with the different time points during scanning.

Training unit 620 is configured as that dose-modulated line is trained to generate model.Training unit 620 can be based on training data Collect to train dose-modulated line to generate model.The training dataset includes multiple sample CT images, multiple sample 3D renderings and more A sample positions picture.Dose-modulated line generate model can be artificial neural network (Artificial Neural Network, ANN) model, such as convolutional neural networks (Convolutional Neural Network, CNN) model, recurrent neural network (Recurrent Neural Network, RNN) model etc..In some embodiments, dose-modulated line generate model can be by It is sent to storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) storage. In some embodiments, dose-modulated line, which generates model, can be universal model or special purpose model.Universal model can be used for generating The dose-modulated of the positioning picture of multiple regions corresponding to multiple types 3D rendering and multiple objects to be scanned or object to be scanned Line.Universal model can be based on multiple sample 3D renderings associated with the different zones of certain class object to be scanned, multiple samples CT image and multiple samples position picture to train.In some embodiments, for trained multiple sample 3D renderings, multiple samples CT image and the positioning of multiple samples are as that can collectively cover entire human body or the entire upper part of the body.For example, universal model can be one A whole body universal model for being suitable for all age brackets and various figures, the whole body universal model can be based on one in any Age bracket, possess any figure object to be scanned 3D rendering and positioning as generating at least one any body of the object to be scanned The dose-modulated line of body region (such as portion, chest, neck, abdomen, pelvis, leg etc.).For training whole body universal model To age, figure and body region, there is no limit can be baby, child, children, adult, the elderly, male to training data Property, women, fat person, the thin weak person of figure multiple sample 3D renderings relevant at least one body region, multiple sample CT Image and multiple samples position picture.Special purpose model corresponds to specific object to be scanned or body region.For example, brain special purpose model can For (or being known as region dosage tune in the other places of the application as generating the dose-modulated line of brain area based on 3D rendering and positioning Line processed).Brain special purpose model can be trained by training dataset corresponding with brain.For another example child's (e.g., 1-6 one full year of life Child) brain special purpose model can be specially adapted for the agent of 3D rendering based on child and positioning as generating child's brain area Measure modulation lines.Child's brain special purpose model can be trained by training dataset corresponding with child's brain.

Dose-modulated line generation unit 630 is configurable to generate dose-modulated line.Dose-modulated line generation unit 630 can It is generated with the dose-modulated line trained based on the 3D rendering and positioning that are obtained by acquiring unit 610 as and by training unit 620 Model generates dose-modulated line.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.Such as, it is convenient to omit training unit 620.Dose-modulated line generation unit 630 can retrieve dose-modulated line from model library generates model.The library includes that multiple general and/or dedicated dose-modulated line is raw At model.The model library can store storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) in, and the storage equipment can be accessed by data processing equipment 140 or its component via such as internet 120.

Fig. 7 is one kind according to shown in some embodiments of the application based on 3D rendering and positioning as determining dose-modulated line Exemplary process diagram.

In 710, the 3D rendering of the available object to be scanned of acquiring unit 610.Acquiring unit 610 can be set from storage Standby (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) obtains the 3D of object to be scanned Image.In some embodiments, acquiring unit 610 can obtain to be scanned from 3D depth camera (such as 3D depth camera 112) The 3D rendering of object.In some embodiments, 3D depth camera can be wrapped from the 3D rendering of multiple angle shot objects to be scanned It includes but is not limited to from front, bottom, side etc..The 3D depth camera can based on stereovision technique, structured light techniques, Flight time (Time-of-Flight, ToF) technology etc., or any combination thereof generate 3D rendering.

In 720, the positioning picture of the available object to be scanned of acquiring unit 610.Acquiring unit 610 can be set from storage Standby (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) obtains determining for object to be scanned Position picture.Positioning is as can be AP positioning picture or lateral register picture.In some embodiments, in operation 720, acquiring unit 610 The AP positioning picture and lateral register picture of available object to be scanned.

In some embodiments, the 3D rendering obtained in operation 710 and the positioning picture obtained in operation 720 can be with bases It is obtained in the data obtained in one or many scannings from equal angular or different angle.It should be noted that positioning is as that can use In the attenuation characteristic and geomery of estimation object to be scanned.In some embodiments, it based on 3D rendering rather than can position As come the geomery of estimating object to be scanned.

In 730, dose-modulated line generation unit 630 can obtain dose-modulated line and generate model.Dose-modulated line is raw It can be from storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, external storage are set at unit 630 It is standby) obtain dose-modulated line generation model.Dose-modulated line generates model can be by the training in advance of model training unit 620.It closes It can be in the finding elsewhere of the application (for example, Fig. 8 and its retouching in the detailed description for generating dosage modulation lines and generating model It states).

In 740, dose-modulated line generation unit 630 can utilize agent based on object to be scanned 3D rendering and positioning picture It measures modulation lines and generates model to generate dose-modulated line relevant to the CT scan of object to be scanned.More specifically, to be scanned right The 3D rendering of elephant and positioning are generated as that can be input to trained dose-modulated line in advance by dose-modulated line generation unit 630 In model.3D rendering and positioning picture in response to input, dose-modulated line generate model and generate dosage modulation lines as output.

In some embodiments, dose-modulated line can show the relationship between sweep time between dose of radiation and time.Spoke Penetrating dosage can be associated with the parameter in scanning device 110, such as tube current-time product, tube current, tube voltage, pitch, has Imitate dosage, absorbed dose etc..Sweep time or time point correspond to specific scanning angle (for example, the radioactivity in X-Y plane The specific configuration in scanning source 113 or position).Time point during scanning may correspond in respective scanned angle wait sweep Retouch the particular slice of object.In some embodiments, dose-modulated line is to indicate dose of radiation at any time or angle consecutive variations Full curve.In some embodiments, dose-modulated line can be discrete, including at least one discrete point, each discrete Point corresponds to the dose of radiation of specific time or angle.In some embodiments, dose-modulated line can be at least one section segmentation The combination of full curve, or the combination of at least one section zonal cooling curve and at least one discrete point.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, operation 710 can execute after operation 720, or operation 710 It is performed simultaneously with operation 720.For another example process 700 includes being based on to 3D rendering and/or positioning as relevant image data next life At the operation of 3D rendering and/or positioning picture.

Fig. 8-A and Fig. 8-B is according to shown in some embodiments of the application for training dose-modulated line to generate model A kind of exemplary process diagram.

In 810, training unit 620 can obtain initial model.Initial model can be artificial neural network (ANN) Model, such as convolutional neural networks (CNN) model, recurrent neural network (RNN) model etc..Initial model includes multiple initial ginsengs Number.In some embodiments, initial model can be predefined.For example, the internal structure or initial parameter of initial model can With according at least one feature of specific object to be scanned (such as chest, head) associated with initial model (such as size, Thickness, complexity) it predefines.

In 820, training unit 620 can obtain training dataset.In some embodiments, training unit 620 can be with Training number is obtained from storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) According to collection.The training dataset includes multiple sample CT images, multiple sample 3D renderings and multiple samples positioning picture.Multiple sample CT The sample 3D rendering and multiple samples that a sample CT image in image corresponds in multiple sample 3D renderings position picture In a sample position picture.Herein, the corresponding relationship of CT image, 3D rendering and positioning as between indicates these sample images generation The table same area of object to be scanned.In short, a sample CT image and corresponding sample 3D rendering and sample Positioning is as that can be designated as a sample image group.Therefore, training dataset includes multiple sample image groups.In some implementations In example, a sample image group is associated with the same area of same object to be scanned or object to be scanned.In some embodiments In, multiple sample image groups are associated with identical or different object to be scanned, or identical at least one object to be scanned Or different zones are associated.

In 830, training unit 620 can generate the generation of dosage modulation lines based on training dataset training initial model Model.For example, the multiple sample image groups concentrated in training data and at least one object to be scanned (for example, brain, head, Chest, leg) the associated situation of same area under, dedicated dose-modulated line can be generated and generate model.In another example more In a sample image group situation associated with the different zones of object to be scanned, general dose-modulated line can be generated and generate mould Type.Training unit 620 can generate model by updating multiple initial parameters to generate dose-modulated line.In some embodiments In, as shown in Fig. 8-B, operation 830 can be divided into operation 831-833.

In 831, for the first sample image group of training dataset, training unit 620 can be based on first sample figure First sample dose-modulated line is determined as the first sample CT image of group.First sample CT image includes attenuation data.One In a little embodiments, training unit 620 can be based on including attenuation data generation and first sample in first sample CT image The corresponding first sample dose-modulated line of CT image.In some embodiments, training unit 620 can be from storage equipment (example Such as, memory 150, disk 270, memory 360, memory module 430, External memory equipment) it searches for and obtains and first sample figure As the corresponding first sample dose-modulated line of first sample CT image of group.

In 832, training unit 620 can first sample 3D rendering based on first sample image group and first sample it is fixed Position picture generates the first predicted dose modulation lines using initial model.

In 833, training unit 620 can be by minimizing first sample dose-modulated line and corresponding first in advance Difference between dose modulation lines trains initial model.Correspondingly, training unit 620 can update the multiple of initial model At least one of original model parameter, and the initial parameter based on update generates the first more new model.

Operation 831-833 can be repeated.In some embodiments, sample dose-modulated line is (for example, first sample agent Measure modulation lines and subsequent samples dose-modulated line) it can be according to loss function with the difference between corresponding predicted dose modulation lines To assess.Loss function includes but is not limited to L1 norm loss function, L2 norm loss function, secondary cost function, cross entropy Loss function, log-likelihood cost function etc., or any combination thereof.It in some embodiments, can be by Different Strategies come more New initial model.For example, if being less than in the difference in current iteration between sample dose-modulated line and predicted dose modulation lines Threshold value (for example, determining difference in previous iterations), then can update some or all of initial model parameter.If current Difference in iteration between sample dose-modulated line and predicted dose modulation lines is greater than the difference in previous ones, then current iteration In not will be updated initial model.In some embodiments, when all multiple sample image groups in training data are traversed or Preset condition is satisfied, and training unit 620 can terminate the iteration of operation 831-833, and generates final trained dosage tune Line processed generates model.Illustrative preset condition includes between sample dose-modulated line and corresponding predicted dose modulation lines Difference at least one subsequent iteration be less than preset threshold value.

With traditional method (such as the shape size of object to be scanned is estimated based on attenuation data of the positioning as in, into And attenuation data and shape size is combined to determine dose-modulated line) compare, the dose-modulated line based on above method training generates Model can obtain the higher dose-modulated line of accuracy.This is because, being instructed using one group of sample image group as training sample During practicing dose-modulated line generation model, reality can be accurately calculated in the CT value information for including based on sample CT image Dose-modulated line (sample dose-modulated line i.e. mentioned above) during border is scanned is based on when sample CT picture quality is better It is more excellent that the dose-modulated line that its corresponding dose-modulated line updates generates model.In addition, being based on 3D due to compared to positioning picture Image can more accurately estimate object to be scanned geomery or 3D profile, and position no wait sweep as containing 3D rendering The attenuation data of object is retouched, generates both the 3D rendering of object to be scanned and positioning picture as dose-modulated line in the present embodiment The input of model, takes full advantage of the respective advantage of the two, and thus obtained dose-modulated line is also more acurrate.It should be noted that Although combining 3D rendering and positioning as that can show advantage as input in some cases, it is only based on 3D rendering or only Based on positioning as determining dose-modulated line also within the scope of protection of this application.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, operation 810 can execute after operation 820, or operation 810 It is performed simultaneously with operation 820.

Fig. 9 is a kind of structural schematic diagram that the dose-modulated line according to shown in the application some embodiments generates model.Such as Shown in Fig. 9, dose-modulated line, which generates model, can be convolutional neural networks (CNN) model.CNN model includes input layer, hides Layer and output layer, and each node in Fig. 9 can be with imictron.Hidden layer includes multiple convolutional layers, multiple tether layers And/or multiple it is fully connected layer (being not shown in Fig. 9).CNN model by process 800 for example shown in Fig. 8 after training, CNN Model is configured to respond to its input and generates dosage modulation lines.In some embodiments, the input of CNN includes positioning as (example As AP position as or lateral register picture) and object to be scanned 3D rendering.In some embodiments, the input of CNN includes wait sweep Two positioning of object are retouched as (for example, such as AP positioning picture and lateral register picture) and 3D rendering.

In some embodiments, model is generated based on dose-modulated line associated with the anatomic region of object to be scanned, Dose-modulated line can be generated.The anatomic region of object to be scanned includes head, neck, chest etc., or any combination thereof.One In a little embodiments, can based on by imaging system 100 or the scan protocols of operator (such as nurse, radiologist) setting come Automatically determine the anatomic region of object to be scanned.In some embodiments, the anatomic region of object to be scanned can be by operator (such as nurse, radiologist) hand labeled as in the 3D rendering of object to be scanned and/or positioning.

For example, operator (such as nurse, radiologist) can execute positioning scanning to patient to obtain the AP of patient And/or lateral register picture, patient's 3D rendering is shot, and select chest scan agreement.In some embodiments, processing equipment 140 The chest of patient can be automatically determined based on selected scan protocols as the anatomic region for executing CT on it.In some embodiments In, operator can the hand labeled one region conduct including patient chest be held on it as in 3D rendering and/or positioning The anatomic region of row CT.In some embodiments, the anatomic region for executing CT scan on it can be based on selected scan protocols Any with operator manually adjusts or correlated inputs determine.CNN model can be based on AP and/or lateral register picture and 3D figure As generating dose-modulated line 910 associated with Thoracic CT scan (as shown in Figure 9).In some embodiments, CNN model Multiple dosimetry parameters and its corresponding angle can be generated in output layer, and can be based on the multiple dosage and angle structure Make (such as passing through interpolation) dose-modulated line 910.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, dose-modulated line, which generates model, can be another type of model, Including but not limited to support vector machines, decision tree, other kinds of ANN model, deep learning model, Bayesian network etc., or Any combination thereof.

Figure 10 is the schematic block diagram of the processing module according to shown in the application some embodiments.Processing module 420 includes Acquiring unit 1010,3D outline specifying unit 1020 and dose-modulated line generation unit 1030.

Processing module 420 includes acquiring unit 1010,3D outline specifying unit 1020 and dose-modulated line generation unit 1030。

Acquiring unit 1010 is configured as obtaining three-dimensional (3D) image (also referred to as depth image) of object to be scanned.One In a little embodiments, acquiring unit 1010 can be from storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) obtain object to be scanned 3D rendering.In some embodiments, acquiring unit 1010 can be from imaging The 3D rendering of equipment (for example, 3D depth camera) acquisition object to be scanned..

In some embodiments, 3D rendering can be shot by 3D depth camera.The 3D profile of object to be scanned can be based on 3D rendering is estimated.3D depth camera can be based on stereovision technique, structured light techniques, flight time (Time-of- Flight, ToF) technology etc., or any combination thereof generate 3D rendering.In some embodiments, 3D depth camera can be from more The 3D rendering of a angle shot object to be scanned, including but not limited to from front, top, side etc..

3D outline specifying unit 1020 is configured as determining the 3D profile of object to be scanned based on 3D rendering.3D rendering packet Include pixel.Some pixel in 3D rendering contains information relevant to some corresponding points on object to be scanned.For example, 3D schemes As in some pixel contain relevant information at a distance from some corresponding points on from 3D depth camera to object to be scanned, The gray value of the corresponding points or color etc., or any combination thereof.The range information of pixel can be used for determining to be scanned in 3D rendering The 3D profile of object.In some embodiments, 3D profile includes cylindrical body, Elliptic Cylinder, cuboid etc..3D profile includes wait sweep The surface texture or shaped size information, such as width, thickness etc. of object are retouched, or any combination thereof.In some embodiments, may be used To generate initial 3D profile.Initial 3D profile is the geometry with multiple default parameters.The initial 3D profile it is multiple Parameter can be determined based on the 3D rendering of object to be scanned.Initial 3D profile can be updated based on the multiple parameter with generate to The 3D profile of sweep object.

Dose-modulated line generation unit 1030 is configured as the 3D rendering based on object to be scanned and generates dosage modulation lines.It is right In each slice of object to be scanned, dose-modulated line generation unit 1030 can determine dose of radiation first.The radiation agent Amount can organ or tissue in 3D profile (such as shape, thickness) based on object to be scanned and/or object to be scanned slice To determine.Dose-modulated line generation unit 1030 can be based on multiple radiation agents corresponding with multiple slices of object to be scanned Amount is to generate dose-modulated line.During CT scan, dose-modulated line be may be used as example by adjusting radioactive scanning source 113 Tube current come execute dose of radiation modulation reference.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, at least one unit in processing module 420 can respectively include one A independent storage unit.

Figure 11 is to determine that one kind of dose-modulated line is exemplary based on 3D rendering according to shown in some embodiments of the application Flow chart.

In 1110, the 3D rendering of the available object to be scanned of acquiring unit 1010.In some embodiments, it obtains single Member 610 can be from storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) Obtain the 3D rendering of object to be scanned.In some embodiments, acquiring unit 1010 can be from imaging device (for example, 3D depth Camera) obtain object to be scanned 3D rendering.

In some embodiments, 3D rendering can be shot by 3D depth camera.The 3D profile of object to be scanned can be based on 3D rendering is estimated.3D depth camera can be based on stereovision technique, structured light techniques, flight time (Time-of- Flight, ToF) technology etc., or any combination thereof generate 3D rendering.In some embodiments, 3D depth camera can be from more The 3D rendering of a angle shot object to be scanned, including but not limited to from front, bottom, side etc..

In 1120,3D outline specifying unit 1020 is configured as determining the 3D wheel of object to be scanned based on the 3D rendering It is wide.Some pixel in 3D rendering contains information relevant to some corresponding points on object to be scanned.For example, in 3D rendering Some pixel contain that relevant information at a distance from some corresponding points on from 3D depth camera to object to be scanned, this is right The gray value that should be put or color etc., or any combination thereof.The range information of pixel can be used for determining object to be scanned in 3D rendering 3D profile.In some embodiments, 3D profile includes cylindrical body, Elliptic Cylinder, cuboid etc..3D profile includes to be scanned Surface texture or shaped size information, such as width, thickness of object etc., or any combination thereof.In some embodiments, it positions 3D profile as can be used for estimation object to be scanned.For example, the 3D profile of object to be scanned can be based on object to be scanned Estimate in attenuation data of the positioning as in.However, since positioning seems to correspond to scanning constant angle (usually vertically downward) 2D image, therefore the shape or size of object to be scanned can not be accurately estimated, especially in transverse direction and inclined direction.In order to This problem is solved, 3D rendering can be used to generate more accurate object to be scanned geomery or 3D profile.It should be noted that Although 3D rendering may be only based on positioning picture or and 3D rendering than positioning as showing slight advantage in some cases Determine 3D profile also within the scope of protection of this application together.

In 1130, dose-modulated line generation unit 1030 can based on the 3D profile of object to be scanned it is determining with it is to be scanned The corresponding dose of radiation of each slice of object.For example, object to be scanned can be divided into multiple slices along Z axis.It is more A slice is parallel to each other.In some embodiments, slice can correspond to specific time and specific scanning angle during scanning.It is right It can be based on object to be scanned in the geomery (such as thickness, width, length) of each slice of object to be scanned, slice 3D profile determines.For example, the cross section of each slice can be ellipse if the 3D profile of object to be scanned is Elliptic Cylinder It is round.The size of oval section or at least one other parameter can be determined based on the 3D profile of object to be scanned.

In some embodiments, it can be determined based on the geomery of slice corresponding to the dose of radiation of each slice. E.g., including the mapping table of the relationship between dose of radiation and the size (such as thickness) of slice can be preset, and It is stored in storage equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment).Agent Amount modulation lines generation unit 1030 may search for mapping table and based on the geomery of slice it is determining with it is each in multiple slices A corresponding dose of radiation.

In 1140, dose-modulated line generation unit 1030 can be based on the more of the multiple slices for corresponding to object to be scanned A dose of radiation generates dose-modulated line.Multiple dose of radiations of multiple slices are determined in dose-modulated line generation unit 1030 Later, dose-modulated line generation unit 1030 can arrange identified more according to the sequence of scanning angle (or direction of Z axis) A dose of radiation is to generate dosage modulation lines.During CT scan, dose-modulated line be can be used as example by adjusting radioactivity The tube current in scanning source 113 come execute dose of radiation modulation reference.In some embodiments, dose-modulated line is to indicate to radiate Dosage is at any time or the full curve of angle consecutive variations.In some embodiments, dose-modulated line can be discrete, including At least one discrete point, each discrete point correspond to the dose of radiation of specific time or angle.In some embodiments, dosage tune Line processed can be the combination of at least one section zonal cooling curve, or at least one section of zonal cooling curve and at least one discrete point Combination.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, operation 1130 and 1140 can be merged into an operation.

Figure 12 is the schematic block diagram of the processing module according to shown in the application some embodiments.Processing module 420 includes Acquiring unit 1210, cutting unit 1220 and dose-modulated line generation unit 1230.

Acquiring unit 1210 is configured as obtaining the positioning picture of object to be scanned.In some embodiments, acquiring unit 1210 can obtain from storage equipment (such as memory 150, disk 270, memory 360, memory module 430, External memory equipment) Take the positioning picture of object to be scanned.In some embodiments, acquiring unit 1210 can be from imaging device (for example, CT scan Instrument, PET-CT scanner) obtain object to be scanned positioning picture.In some embodiments, positioning as can be AP positioning as or Lateral register picture.In some embodiments, the AP positioning picture and lateral register of the available object to be scanned of acquiring unit 610 Picture.

In some embodiments, acquiring unit 1210 is configured as obtaining with reference to 3D rendering.In some embodiments, it refers to 3D rendering can be associated with object to be scanned.For example, can be and the same or similar ginseng of object to be scanned with reference to 3D rendering Examine a recent images of object to be scanned (for example, same type or region).More specifically, with reference to object to be scanned and wait sweep Retouching object can have the same or similar physical qualification, such as same or similar 3D chamfered shape size, identical internal group It knits or organ etc., or any combination thereof.

Cutting unit 1220 is configured as the positioning picture of object to be scanned being divided at least one area-of-interest.It is described Each of at least one area-of-interest corresponds to an anatomic region of object to be scanned, such as head, neck, chest Deng.In some embodiments, cutting unit 1220 can will be positioned as being divided at least one automatically based on image segmentation algorithm Area-of-interest.Illustrative image segmentation algorithm includes thresholding algorithm, clustering algorithm, the algorithm based on histogram, region life Long algorithm etc., or any combination thereof.In some embodiments, operator (such as nurse, radiologist) will can determine manually Position is as being divided at least one area-of-interest.In some embodiments, positioning by automanual mode as that can be divided into At least one area-of-interest, for example, first automatic coarse segmentation is manually adjusted by operator cutting unit 1220 again or operator is first It is preliminary selected again by 1220 Accurate Segmentation of cutting unit manually.

Dose-modulated line generation unit 1230 is configurable to generate dose-modulated line.Dose-modulated line generation unit 1230 It can determine reference location picture corresponding with area-of-interest, and determine region dosage tune based on the reference location picture Line processed.Dose-modulated line generation unit 1230 can combine multiple regions dose-modulated line to generate dosage modulation lines.It is exemplary Dose-modulated line can be found in, such as Figure 15.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, at least one unit in processing module 420 can respectively include only Vertical storage unit.

Figure 13 is based on positioning according to shown in some embodiments of the application as the one kind for determining dose-modulated line is exemplary Flow chart.

In 1310, the positioning picture of the available object to be scanned of acquiring unit 1210.Acquiring unit 1210 can be from depositing It stores up equipment (for example, memory 150, disk 270, memory 360, memory module 430, External memory equipment) and obtains object to be scanned Positioning picture.In some embodiments, positioning is as can be AP positioning picture or lateral register picture.In some embodiments, it is grasping Make in 1310, the AP positioning picture and lateral register picture of the available object to be scanned of acquiring unit 1210.

In 1320, cutting unit 1220 divides the positioning picture of object to be scanned to position described as upper determination at least one A area-of-interest.Each of at least one described area-of-interest corresponds to an anatomic region of object to be scanned, Such as head, neck, chest etc..In some embodiments, cutting unit 1220 can be divided automatically based on image segmentation algorithm Position picture.Illustrative image segmentation algorithm includes thresholding algorithm, clustering algorithm, the algorithm based on histogram, region growing calculation Method etc., or any combination thereof.In some embodiments, operator (such as nurse, radiologist) can be positioned with manual segmentation Picture.In some embodiments, positioning by automanual mode as that can be divided, for example, the first automatic rough segmentation of cutting unit 1220 It cuts and is manually adjusted again by operator or operator is first preliminary selected again by 1220 Accurate Segmentation of cutting unit manually.

In 1330, dose-modulated line generation unit 1230 can determine at least one region dose-modulated line, it is described extremely Each in a few strip area dose-modulated line corresponds to one at least one area-of-interest of positioning picture.Some In embodiment, dose-modulated line or region dose-modulated line can be continuous curve, embody dose of radiation at any time or angle Consecutive variations.In some embodiments, dose-modulated line or region dose-modulated line can be discrete, including at least one Discrete point, each discrete point correspond to the dose of radiation of specific time or angle.In some embodiments, the area dose-modulated Xian Huo Domain dose-modulated line can be the combination of at least one section zonal cooling curve, or at least one section of zonal cooling curve and at least one The combination of discrete point.The detailed description of determination about at least one region dose-modulated line can the application elsewhere Find (for example, Figure 14 and its description).

In 1340, dose-modulated line generation unit 1230 can be generated based on at least one region dose-modulated line Dose-modulated line relevant to the CT scan of object to be scanned.In operation 1320, it is determined that at least one region dose-modulated After line, dose-modulated line generation unit 1230 can combine an at least strip area dose-modulated line to generate dosage modulation lines. In some embodiments, smoothing processing can be executed to dose-modulated line generated, to avoid the side of region dose-modulated line The mutation of the corresponding dose of radiation of boundary's point.

In some embodiments, the dose-modulated line determined in 1340 can be used as reference dose modulation lines, for examining Whether the scan protocols for looking into setting are accurate.For example, before operation 1310, it can be by operator (such as nurse, radiologist) An initial scan protocol is set for object to be scanned automatically manually or by imaging system 100.Acquiring unit 1210 can be based on Initial scan protocol obtain object to be scanned positioning picture, dose-modulated line generation unit 1230 can based on the positioning picture with Initial scan protocol determines predose modulation lines.Aforesaid operations 1310-1340 is based in imaging system 100 to have determined with reference to agent After measuring modulation lines, predose modulation lines and reference dose modulation lines can be compared.If predose modulation lines Difference between reference dose modulation lines is greater than preset threshold, then imaging system 100 reminds operator (such as nurse, radiation Section doctor) initial scan protocol inaccuracy.For example, imaging system 100 can be by way of voice or by operation interface The mode of upper display reminding information reminds operator.In some embodiments, initial scan protocol can be repaired manually by operator Just or by the automatic amendment based on comparative result of imaging system 100.For example, imaging system 100 can repair automatically based on comparative result Positive scan protocols simultaneously show correction result in operation interface for operator's confirmation.For another example knowing scan protocols not After accurate prompt information, operator can check scan protocols manually and is modified in operation interface.In this way, scanning Imaging system 100 can remind in time operator and be modified when agreement inaccuracy, improve the accuracy of dose-modulated line. The high dose-modulated line of accuracy further ensures the quality of the CT image of subsequent reconstruction, and then provides more accurately diagnosis letter Breath.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, available two positioning are as (such as AP is positioned in operation 1310 Picture and lateral register picture).

Figure 14 is according to shown in some embodiments of the application for determining a kind of exemplary stream of region dose-modulated line Cheng Tu.

In 1410, dose-modulated line generation unit 1230 can extract at least one sense of the locating plate of object to be scanned The feature of each of interest region area-of-interest.The feature in the region includes textural characteristics, geomery, space spy Sign etc., or any combination thereof.In some embodiments, the different zones of the locating plate of object to be scanned have different characteristics. In some embodiments, dose-modulated line generation unit 1230 can extract at least one region of interest based on Feature Extraction Technology The feature in each of domain.Textural characteristics can be extracted according to texture feature extraction technology, such as spatial texture feature mentions Take technology and spectrum texture feature extraction technology.Geomery can be based on, for example, profile technology and technology based on region. Space characteristics can be extracted according to space characteristics extractive technique, such as the technology based on absolute spatial position and based on relatively empty Between position technology.

In 1420, dose-modulated line generation unit 1230 can be at least one area-of-interest based on the feature of extraction Each of determine reference location picture.It is every at least one area-of-interest based on the feature extracted in operation 1410 One can be indicated by feature vector.In some embodiments, multiple candidate positioning as can store storage equipment (for example, Memory 150, disk 270, memory 360, memory module 430, External memory equipment) in, and multiple candidate positioning are as in Each can be indicated by feature vector.If the feature vector of some candidate's positioning picture in a region and the feature in the region Vectors matching is to acceptable degree, then the candidate positions as that can be designated as the reference location picture corresponding to the region.Only As an example, the positioning picture of object to be scanned chest can correspond to first eigenvector.Multiple candidate positioning are as that can correspond to In the multiple regions for including head, chest, neck, abdomen, pelvis, leg etc..It in some embodiments, can be from multiple candidates Positioning selection as in has and the matched second feature vector of first eigenvector of the chest of the positioning picture of object to be scanned Reference picture.The reference picture includes chest similar with chest of the positioning as in.As used in this application, candidate fixed Position with Region Matching to acceptable degree as indicating candidate positioning as being lower than threshold value with the difference between region.It can be according to time At least one characteristic value of the feature vector in position picture and region is selected to assess the difference.

In 1430, dose-modulated line generation unit 1230 can be that at least one sense is emerging based on corresponding reference location picture Each of interesting region area-of-interest determines region dose-modulated line.Corresponding reference location picture can be swept with such as head It is associated to retouch the scan protocols such as agreement, neck scan protocols, chest scan agreement.In some embodiments, scan protocols include Sweep parameter, such as the voltage in radioactive scanning source 113, tube current-time product, beam width, gantry rotation times, reconstruct Core etc., or any combination thereof.Different scan protocols can have identical or different sweep parameter.For example, different scanning Agreement can have some identical sweep parameters and some different sweep parameters.In some embodiments, dose-modulated line Generation unit 1230 can based on corresponding reference location as associated scan protocols at least one sweep parameter come really The region dose-modulated line of each of at least one fixed area-of-interest.In some embodiments, at least one sense Each of interest region, the region of the positioning of the available object to be scanned of dose-modulated line generation unit 1230 as in At least one image parameter (for example, the gray value of pixel, average gray value, contrast), and extremely based on the region Lack an image parameter and determines this as at least one sweep parameter of associated scan protocols with corresponding reference location The region dose-modulated line in region.

It is at least that dose-modulated line generation unit 1230, which can generate model based on dose-modulated line, in some embodiments Each of one area-of-interest determines region dose-modulated line (for example, with reference to Fig. 7 and its description).Such as institute in the application It uses, it can be by the corresponding reference location picture determined in operation 1420 and/or reference 3D rendering (for example, this refers to 3D Image is obtained by acquiring unit 1210, referring to the associated description of acquiring unit 1210) it is appointed as dose-modulated line generation model Input.It can be at least one region of interest based on corresponding reference location picture and with reference to 3D rendering that dose-modulated line, which generates model, Each of domain formation zone dose-modulated line.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, operation 1430 can be divided into one group of sub-operation.Dose-modulated line is raw It can be determined in sub-operation with reference location at unit 1230 as associated scan protocols, and the base in another sub-operation In at least one parameter formation zone dose-modulated line of the scan protocols.In another example operation 1430 can be divided into not Same sub-operation set.Dose-modulated line generation unit 1230 can obtain dose-modulated line in the first sub-operation and generate model With reference 3D image, and in the second sub-operation based on dose-modulated line generate model, with reference to 3D rendering and reference location picture Formation zone dose-modulated line.

As shown in figure 15, scanning device 110 can execute whole body CT scan to patient.Whole body CT scan may include scanning Neck, chest, abdomen and the pelvis of patient.Scanning device 110 can be schemed using the 3D that 3D depth camera 112 shoots patient first Then picture executes positioning scanning to patient to generate positioning picture.

In some embodiments, processing equipment 140 can be by positioning as being divided into three area-of-interests: neck (region 1), chest (region 2) and abdomen and pelvis (region 3).Processing equipment 140 can determine three reference location pictures: neck phase It closes reference location picture, chest coherent reference positioning picture and abdominal-pelvic coherent reference and positions picture.For each area-of-interest, Processing equipment 140 can determine region dose-modulated line based on reference location picture associated with the region.For example, processing is set Standby 140 can determine neck as at least one sweep parameter in associated scan protocols based on positioning with neck coherent reference Portion relevant range dose-modulated line.In another example processing equipment 140 can be by positioning picture and 3D for the neck coherent reference of patient Image is input to dose-modulated line and generates model to determine neck relevant range dose-modulated line.Obtaining the agent of neck relevant range After measuring modulation lines, chest relevant range dose-modulated line and abdominal-pelvic relevant range dose-modulated line, processing equipment 140 The region dose-modulated line can be combined to generate dosage modulation lines 1510.It in some embodiments, can be to generated Dose-modulated line executes smoothing processing, to avoid the mutation of the corresponding dose of radiation of boundary point of region dose-modulated line.

It should be noted that foregoing description is not merely to explanation, constitutes the limitation to the application range.For ability For the those of ordinary skill in domain, various amendments or change can be made according to the description of the present application.However, these Modifications and variations are without departing from scope of the present application.For example, being more than three (for example, four, five) region dose-modulated line quilts It determines, is then combined to generate corresponding dose-modulated line.In another example dose-modulated line and/or region dose-modulated line It can be discrete, including at least one discrete point, rather than a continuous curve, each discrete point correspond to specific time Or the dose of radiation of angle.

Basic conception is described above, it is clear that those skilled in the art, foregoing invention discloses only As an example, and not constituting the restriction to the application.Although do not clearly state herein, those skilled in the art may The application is carry out various modifications, improve and is corrected.Such modification, improvement and amendment are proposed in this application, so such Modification improves, corrects the spirit and scope for still falling within the application example embodiment.

Meanwhile the application has used specific term to describe embodiments herein.For example, term " one embodiment ", " embodiment ", and/or " some embodiments " means a certain feature relevant at least one embodiment of the application, structure or spy Point.Therefore, it should be emphasized that simultaneously it is noted that " embodiment " or " one that is referred to twice or repeatedly in the application in different location A embodiment " or " alternate embodiment " are not necessarily referring to the same embodiment.In addition, at least one embodiment of the application Certain features, structure or feature can carry out combination appropriate.

In addition, it will be understood by those skilled in the art that the various aspects of the application can be by several with patentability Type or situation are illustrated and described, the combination or right including any new and useful process, machine, product or substance Their any new and useful improvement.Correspondingly, the various aspects of the application can completely by hardware implement, can be complete Implemented by software (including firmware, resident software, microcode etc.), can also be implemented by combination of hardware.Hardware above or Software is referred to alternatively as " unit ", " module " or " system ".In addition, the various aspects of the application may show as being located at least one Computer product in computer-readable medium, the product include computer-readable program coding.

Computer-readable signal media may include the propagation data signal containing computer program code in one, such as A part in base band or as carrier wave.The transmitting signal may there are many forms of expression, including electromagnetic form, light form etc. Deng or suitable combining form.Computer-readable signal media can be any meter in addition to computer readable storage medium Calculation machine readable medium, the medium can be realized by being connected to an instruction execution system, device or equipment communication, propagate or Transmit the program for using.Program coding in computer-readable signal media can be carried out by any suitable medium It propagates, the combination including radio, cable, fiber optic cables, RF or similar mediums or any of above medium.

Computer program code needed for the operation of the application various aspects can use any group of one or more program languages It compiles in collaboration with and writes, including Object-Oriented Programming Languages, such as Java, Scala, Smalltalk, Eiffel, JADE, Emerald, C ++, C#, VB, NET, Python etc. or similar conventional program programming language, such as " C " programming language, Visual Basic, Fortran 2003, Perl, COBOL 2002, PHP, ABAP, dynamic programming language such as Python, Ruby and Groovy or other Programming language.The program coding can be run on the user computer or as independent software package in subscriber computer completely Upper operation or part are run or completely in remote computer or service operation part on the user computer in remote computer It is run on device.In the latter cases, remote computer can be connect by any latticed form with subscriber computer, such as local Net (LAN) or wide area network (WAN), or it is connected to outer computer (such as passing through internet), or in cloud computing environment, or make (Software as a Service, SaaS) is serviced using such as software for service.

In addition, except clearly stating in non-claimed, the sequence of herein described processing element and sequence, digital alphabet Using or other titles use, be not intended to limit the sequence of the application process and method.Although by each in above-mentioned disclosure Kind of example discuss it is some it is now recognized that useful inventive embodiments, but it is to be understood that, such details only plays explanation Purpose, appended claims are not limited in the embodiment disclosed, on the contrary, claim is intended to cover and all meets the application The amendment and equivalent combinations of embodiment spirit and scope.For example, although system component described above can be set by hardware It is standby to realize, but can also be only achieved by the solution of software, such as pacify on existing server or mobile device Fill described system.

Similarly, it is noted that in order to simplify herein disclosed statement, to help to implement at least one invention The understanding of example, above in the description of the embodiment of the present application, sometimes by various features merger to one embodiment, attached drawing or right In its description.But this disclosure method is not meant to refer in aspect ratio claim required for the application object Feature it is more.In fact, the feature of embodiment will be less than whole features of the single embodiment of above-mentioned disclosure.

Claims

1. a kind of method of determining dose of radiation modulation lines, which is characterized in that the described method includes:

Obtain the 3-D image of object to be scanned；

The three-D profile of the object to be scanned is determined based on the 3-D image；

Based on the three-D profile of the object to be scanned, determine that corresponding X is penetrated for each slice of the object to be scanned Line dosage；With

Based on the x-ray dose of each slice, dose-modulated line relevant to the CT scan of the object to be scanned is determined.

2. the method as described in claim 1, which is characterized in that described to determine the object to be scanned based on the 3-D image Three-D profile, comprising:

Determine initial three-D profile；

At least one parameter of the initial three-D profile is determined based on the 3-D image；With

Based at least one described parameter, the initial three-D profile is updated.

3. the method as described in claim 1, which is characterized in that the three-D profile based on the object to be scanned, for institute The each slice for stating object to be scanned determines corresponding x-ray dose, comprising:

Based on the three-D profile of the object to be scanned, at least one described slice is determined；

Determine the size of at least one slice；

Mapping table is obtained, the mapping table includes the corresponding relationship between x-ray dose and slice size；With based on it is described at least The size of one slice searches for the mapping table with the corresponding x-ray dose of determination.

4. the method as described in claim 1, which is characterized in that including adjusting CT equipment radioactivity based on the dose-modulated line The tube current in scanning source.

5. the method as described in claim 1, which is characterized in that the 3-D image of the object to be scanned is based on stereoscopic vision skill Art, structured light techniques or flying time technology determine.

6. the method as described in claim 1, which is characterized in that the three-D profile of the object to be scanned is cylindrical body, ellipse Cylinder or cuboid.

7. the method as described in claim 1, which is characterized in that the object to be scanned includes the head of patient, chest, neck At least one of portion, abdomen, pelvis or leg.

8. the method as described in claim 1, which is characterized in that the method also includes:

Obtain the positioning picture of the object to be scanned；With

The dosage tune relevant to the CT scan of the object to be scanned is determined based on the positioning picture and the 3-D image Line processed.

9. a kind of system of determining dose of radiation modulation lines, comprising:

Acquiring unit is configured as obtaining the 3-D image of object to be scanned；

Three-D profile determination unit is configured as determining the three-D profile of the object to be scanned based on the 3-D image；With

Dose-modulated line generation unit, is configured as:

10. a kind of device of determining dose of radiation modulation lines, including storage medium and at least one processor；

The storage medium includes computer instruction；With

At least one described processor is for executing the computer instruction to realize the described in any item sides of claim 1-7 Method.