CN109124567A - A kind of monitoring system and method based on intraocular pressure and intracranial pressure linear relationship - Google Patents

A kind of monitoring system and method based on intraocular pressure and intracranial pressure linear relationship Download PDF

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Publication number
CN109124567A
CN109124567A CN201811186706.6A CN201811186706A CN109124567A CN 109124567 A CN109124567 A CN 109124567A CN 201811186706 A CN201811186706 A CN 201811186706A CN 109124567 A CN109124567 A CN 109124567A
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China
Prior art keywords
pressure
monitoring
intraocular pressure
intraocular
intracranial
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Pending
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CN201811186706.6A
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Chinese (zh)
Inventor
刘伟平
倪诚
韩永正
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Peking University Third Hospital
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Peking University Third Hospital
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Priority to CN201811186706.6A priority Critical patent/CN109124567A/en
Publication of CN109124567A publication Critical patent/CN109124567A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/0215Measuring pressure in heart or blood vessels by means inserted into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/03Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/031Intracranial pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • A61B5/279Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]

Abstract

The invention belongs to technical field of medical equipment, disclose a kind of monitoring system and method based on intraocular pressure and intracranial pressure linear relationship;It is provided with information and integrates module, measure of intraocular pressure module, vital sign monitoring modular, Lumbar catheter pressure monitoring module.The measure of intraocular pressure module, vital sign monitoring modular, Lumbar catheter pressure monitoring module are all integrated module with information and are connect independently of each other, are independent of each other.The vital sign monitoring modular is divided into including electrocardiogram monitoring unit, invasive angiosthenia power monitoring unit, double frequency eeg monitoring unit.Module integrated above-mentioned data are integrated by information, are shown for information, information stores and integrates with information.Linear relationship of the system based on intraocular pressure and intracranial pressure reflects the variation of intracranial pressure by the measurement to intraocular pressure indirectly, is applied to monitoring intracranial pressure in general anesthesia patients, provides a kind of effective non-invasive monitoring means.

Description

A kind of monitoring system and method based on intraocular pressure and intracranial pressure linear relationship
Technical field
The invention belongs to technical field of medical equipment more particularly to a kind of prisons based on intraocular pressure and intracranial pressure linear relationship Examining system and method.
Background technique
Intracranial pressure, i.e., the pressure of cerebrospinal fluid in cranial cavity are normally the 100-150 millimeter of water, 10-15 millimetres of mercury;According to Technical ability guide p325 is practiced in national examination to determine the qualifications of doctors, and cerebrospinal pressure is 0.78~1.76kpa (80 when normal adult's clinostatism ~180 millimeters of water) or 40~50 drops/min, with respiration wave within 10 millimeters of water, children's pressure is 0.4~1.0kpa (40~100 millimeter of water).Monitoring intracranial pressure is most important in neurocranial surgery and other operations for being related to intracranial pressure variation, It is fluctuation since encephalic is affected by many factors, measured pressure only has opposite meaning within the unit time.Compared with The case where correctly understanding intracranial pressure, the method that lasting pressure measurement and record should be used.Pressure continuously is measured and recorded, it can Intracranial pressure change conditions are understood at any time, and can obtain more accurate cranial cavity intracranial pressure data, lack effective non-invasive monitoring at present Means.Intraocular pressure, that is, eye internal pressure, the formation of intraocular pressure depend on the amount of aqueous humor with maintenance.And aqueous humor passes through trabecular network approach Central vein of retina and venae vorticosae are flowed back into respectively with uveal scleral approach, finally flow back into the cavernous sinus positioned at encephalic. Therefore when intracranial pressure influences the venous return of cavernous sinus, the reflux of aqueous humor will receive influence, and then influence intraocular Pressure.Lack effective non-invasive monitoring means at present, existing invasive means include that Lumbar catheter persistently surveys pressure, intracranial pressure directly measures Deng being invasive operation.Lumbar catheter persistently surveys pressure and veteran doctor is needed to carry out cavum subarachnoidale puncture, and intracranial pressure is straight It connects measurement to need to apply in the case where opening cranium, the two presence restrictive conditions such as infection, damage, technical level, and noninvasive pressure Power monitoring means is less, such as B ultrasound eyeground measurement vagina nervi optici diameter (ONSD), lacks quantitative target, is only capable of doing qualitative processing, Perioperative is continued to monitor and is had little significance.
In conclusion problem of the existing technology is: existing means are invasive operation, and there are many restrictions conditions, and Non-invasive pressure monitoring means is less, and a kind of convenience, the effective noninvasive means that continue to monitor urgently are invented.Non -invasivetesting can be to avoid Damage to patient is continuously monitored applied to perioperative, relative to invasive monitoring, can have longer monitoring time, for disease Disease progress and lapsed to better directive function.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of prison based on intraocular pressure and intracranial pressure linear relationship Examining system and method.
The invention is realized in this way a kind of monitoring method based on intraocular pressure and intracranial pressure linear relationship, described to be based on Linear relationship of the monitoring method of intraocular pressure and intracranial pressure linear relationship based on intraocular pressure and intracranial pressure, directly measurement intraocular pressure Power estimates the variation numerical value of intracranial pressure according to the variation degree of intraocular pressure.
Further, the monitoring method based on intraocular pressure and intracranial pressure linear relationship specifically includes:
(1) 3-5 intraocular pressure in 1 minute is measured for the first time, is worth on the basis of being averaged, and is spaced 3-5 minutes surveys again later Intraocular pressure is measured, changing percentage compared with a reference value is that intracranial pressure changes percentage;
(2) intraocular pressure a reference value measuring phases can set intracranial pressure a reference value, be defaulted as normal pressure value or preoperative Measured value calculates change pressure value according to variation percentage after intraocular pressure variation;Information display module shows intraocular pressure, eye Internal pressure changes the intracranial pressure of percentage, estimation.
Further, the monitoring method based on intraocular pressure and intracranial pressure linear relationship further comprises:
Step 1, uses tonometer by measure of intraocular pressure module and bilateral Corneal Contact is 3~6 times, obtains several electricity Corrugating, voltage wave are transmitted in its internal miniature information processing instrument for having single IC block to constitute after being amplified, Remove incorrect waveform after miniature information is handled, correct waveform is become into number and store, correctly measurement obtains every time A data are obtained, after 3-6 measurement, miniature information processing instrument will respectively obtain double after 3-6 data of acquisition are averaged The millimetres of mercury value of side average intraocular pressure;
Step 2 obtains bilateral intraocular pressure and time changing curve according to bilateral intraocular pressure and time respectively, and is fitted pressure change Change time index;Heart is monitored by the electrocardiogram monitoring unit of vital sign monitoring modular, passes through invasive angiosthenia Power monitoring unit is monitored blood pressure, is monitored by double frequency eeg monitoring unit to brain states;
Step 3 is cranium by Lumbar catheter pressure monitoring module Lumbar catheter pressure monitoring, the directly variation of reaction intracranial pressure The invasive monitoring means of interior pressure, for being not suitable for non-invasive monitoring or needing the operation of successive reaction pressure change;Pass through information Module integrated data are integrated, are shown for information, information stores and integrates with information;
Step 4, information display screen provide vital signs in real time, arterial pressure, depth of anesthesia, bilateral intraocular pressure and waist Great Chi pressure value is fitted intraocular pressure rate of change after integration, and provides each numerical value and time curve;It is based on The linear relationship of intraocular pressure and intracranial pressure reflects the variation of intracranial pressure by the measurement to intraocular pressure indirectly, is applied to general anesthesia patients Middle monitoring intracranial pressure.
Another object of the present invention is to provide the monitorings described in a kind of operation based on intraocular pressure and intracranial pressure linear relationship The monitoring system based on intraocular pressure and intracranial pressure linear relationship of method, the prison based on intraocular pressure and intracranial pressure linear relationship Examining system includes:
Information for being integrated to detection information integrates module;
For measuring the measure of intraocular pressure module of intraocular pressure;
Vital sign monitoring modular for being monitored to vital sign;
Lumbar catheter pressure monitoring module for Lumbar catheter pressure monitoring;
The measure of intraocular pressure module, vital sign monitoring modular, Lumbar catheter pressure monitoring module and information integrate module Mutually indepedent connection.
Further, the vital sign monitoring modular includes:
Electrocardiogram monitoring unit for being monitored to heart;
The wound arterial pressure monitoring unit that blood pressure is monitored;
The double frequency eeg monitoring unit that brain states are monitored.
Another object of the present invention is to provide the monitorings described in a kind of realize based on intraocular pressure and intracranial pressure linear relationship The computer program of method.
Another object of the present invention is to provide the monitorings described in a kind of realize based on intraocular pressure and intracranial pressure linear relationship The information data processing terminal of method.
Another object of the present invention is to provide a kind of computer readable storage mediums, including instruction, when it is in computer When upper operation, so that computer executes the monitoring method based on intraocular pressure and intracranial pressure linear relationship.
Advantages of the present invention and good effect are as follows: be somebody's turn to do the monitoring system based on intraocular pressure and intracranial pressure linear relationship and side Method measures intraocular pressure by measure of intraocular pressure module, raw to basis by the electrocardiogram monitoring unit of vital sign monitoring modular Sign monitoring is ordered, by invasive angiosthenia power monitoring unit to hemodynamic monitoring, passes through double frequency eeg monitoring unit pair Depth of anesthesia is monitored.By Lumbar catheter pressure monitoring module Lumbar catheter pressure monitoring, intracranial pressure change can be directly reacted Change, is the invasive monitoring means of intracranial pressure, for being not suitable for non-invasive monitoring or needing the operation of successive reaction pressure change.It is logical It crosses information and integrates module integrated above-mentioned data, shown for information, information stores and integrates with information.
Linear relationship of the system based on intraocular pressure and intracranial pressure reflects intracranial pressure by the measurement to intraocular pressure indirectly Variation, be applied to general anesthesia patients in monitoring intracranial pressure, provide a kind of effective non-invasive monitoring means.
Detailed description of the invention
Fig. 1 is provided in an embodiment of the present invention based on the signal of the monitoring system structure of intraocular pressure and intracranial pressure linear relationship Figure;
Fig. 2 is the monitoring method flow chart provided in an embodiment of the present invention based on intraocular pressure and intracranial pressure linear relationship.
In figure: 1, information integrates module;2, measure of intraocular pressure module;3, vital sign monitoring modular;3-1, electrocardiogram prison Survey unit;3-2, invasive angiosthenia power monitoring unit;3-3, double frequency eeg monitoring unit;4, Lumbar catheter pressure monitoring module.
Specific embodiment
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and cooperate attached drawing Detailed description are as follows.
Structure of the invention is explained in detail with reference to the accompanying drawing.
As shown in Figure 1, provided in an embodiment of the present invention be arranged based on the monitoring system of intraocular pressure and intracranial pressure linear relationship Have: the information for being integrated to detection information is integrated module 1, the measure of intraocular pressure module 2 for measuring intraocular pressure, is used for Vital sign monitoring modular 3 that vital sign is monitored, the Lumbar catheter pressure monitoring module for Lumbar catheter pressure monitoring 4。
The measure of intraocular pressure module 2, vital sign monitoring modular 3, Lumbar catheter pressure monitoring module 4 are all integrated with information Module 1 connects independently of each other, is independent of each other.
The vital sign monitors 3 pieces of mould divide into include: electrocardiogram monitoring unit 3-1 for being monitored to heart, The wound arterial pressure monitoring unit 3-2 that blood pressure is monitored, the double frequency eeg monitoring unit that brain states are monitored 3-3。
As shown in Fig. 2, the monitoring method provided in an embodiment of the present invention based on intraocular pressure and intracranial pressure linear relationship includes Following steps:
S201: the linear relationship based on intraocular pressure and intracranial pressure, directly measurement intraocular pressure, according to the variation of intraocular pressure Degree estimates the variation numerical value of intracranial pressure;3-5 intraocular pressure in 1 minute is measured for the first time, is worth on the basis of being averaged, later Interval 3-5 minutes (interval time can be changed manually) measures intraocular pressure again, and changing percentage compared with a reference value is encephalic Pressure change percentage;
S202: intraocular pressure a reference value measuring phases can set intracranial pressure a reference value, be defaulted as normal pressure value or art Preceding measured value (needing voluntarily manual measurement or the invasive measurement of Lumbar catheter), calculates variation according to variation percentage after intraocular pressure variation Pressure value;Information display module shows that intraocular pressure, intraocular pressure change the intracranial pressure of percentage, estimation.
The working principle of the invention is: the device uses tonometer and bilateral Corneal Contact by measure of intraocular pressure module 1 It is 3~6 times, obtains several voltage waveforms, these voltage waves are transmitted to its internal one after being amplified has single IC block In the miniature information processing instrument of composition, remove incorrect waveform after miniature information is handled, correct waveform is become into number And store, correctly measurement can be obtained a data every time, and after 3-6 time measures, miniature information processing instrument is by acquisition The millimetres of mercury value of bilateral average intraocular pressure will be respectively obtained after 3-6 data are average.It is obtained respectively according to bilateral intraocular pressure and time Bilateral intraocular pressure and time changing curve, and it is fitted pressure change time index.It is supervised by the electrocardiogram of vital sign monitoring modular 3 It surveys unit 3-1 to be monitored heart, blood pressure is monitored by invasive angiosthenia power monitoring unit 3-2, passes through double frequency brain Electrograph monitoring unit 3-3 is monitored brain states.It, can be with by 4 Lumbar catheter pressure monitoring of Lumbar catheter pressure monitoring module Directly reaction intracranial pressure variation is the invasive monitoring means of intracranial pressure, for being not suitable for non-invasive monitoring or needing continuous anti- Answer the operation of pressure change.Module 1 is integrated by information and integrates above-mentioned data, is shown for information, information stores and and information Integration.Information display screen provides vital signs in real time, arterial pressure, depth of anesthesia, bilateral intraocular pressure and Lumbar catheter number pressure Value is fitted intraocular pressure rate of change after integration, and provides each numerical value and time curve.The system is based on intraocular The linear relationship of pressure and intracranial pressure reflects the variation of intracranial pressure by the measurement to intraocular pressure indirectly, is applied to general anesthesia patients mesocrany Inspection of inner pressure provides a kind of effective non-invasive monitoring means.
In the above-described embodiments, can come wholly or partly by software, hardware, firmware or any combination thereof real It is existing.When using entirely or partly realizing in the form of a computer program product, the computer program product include one or Multiple computer instructions.When loading on computers or executing the computer program instructions, entirely or partly generate according to Process described in the embodiment of the present invention or function.The computer can be general purpose computer, special purpose computer, computer network Network or other programmable devices.The computer instruction may be stored in a computer readable storage medium, or from one Computer readable storage medium is transmitted to another computer readable storage medium, for example, the computer instruction can be from one A web-site, computer, server or data center pass through wired (such as coaxial cable, optical fiber, Digital Subscriber Line (DSL) Or wireless (such as infrared, wireless, microwave etc.) mode is carried out to another web-site, computer, server or data center Transmission).The computer-readable storage medium can be any usable medium or include one that computer can access The data storage devices such as a or multiple usable mediums integrated server, data center.The usable medium can be magnetic Jie Matter, (for example, floppy disk, hard disk, tape), optical medium (for example, DVD) or semiconductor medium (such as solid state hard disk Solid State Disk (SSD)) etc..
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form, Any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to In the range of technical solution of the present invention.

Claims (8)

1. a kind of monitoring method based on intraocular pressure and intracranial pressure linear relationship, which is characterized in that described to be based on intraocular pressure and cranium Linear relationship of the monitoring method of internal pressure linear relationship based on intraocular pressure and intracranial pressure, directly measurement intraocular pressure, according to intraocular The variation degree of pressure estimates the variation numerical value of intracranial pressure.
2. the monitoring method based on intraocular pressure and intracranial pressure linear relationship as described in claim 1, which is characterized in that the base It is specifically included in the monitoring method of intraocular pressure and intracranial pressure linear relationship:
(1) 3-5 intraocular pressure in 1 minute is measured for the first time, is worth on the basis of being averaged, and is spaced 3-5 minutes measures eye again later Interior pressure, changing percentage compared with a reference value is that intracranial pressure changes percentage;
(2) intraocular pressure a reference value measuring phases can set intracranial pressure a reference value, be defaulted as normal pressure value or preoperative measurement Value calculates change pressure value according to variation percentage after intraocular pressure variation;Information display module shows intraocular pressure, intraocular pressure Change the intracranial pressure of percentage, estimation.
3. the monitoring method based on intraocular pressure and intracranial pressure linear relationship as described in claim 1, which is characterized in that the base Further comprise in the monitoring method of intraocular pressure and intracranial pressure linear relationship:
Step 1, uses tonometer by measure of intraocular pressure module and bilateral Corneal Contact is 3~6 times, obtains several voltage waves Shape, voltage wave is transmitted in its internal miniature information processing instrument for having single IC block to constitute after being amplified, through micro- Remove incorrect waveform after type information processing, correct waveform is become into number and store, correctly measurement obtains one every time A data, after 3-6 measurement, miniature information processing instrument will respectively obtain bilateral after 3-6 data of acquisition are averaged and put down The millimetres of mercury value of equal intraocular pressure;
Step 2 obtains bilateral intraocular pressure and time changing curve according to bilateral intraocular pressure and time respectively, and when being fitted pressure change Between index;Heart is monitored by the electrocardiogram monitoring unit of vital sign monitoring modular, is supervised by invasive angiosthenia power It surveys unit to be monitored blood pressure, brain states is monitored by double frequency eeg monitoring unit;
Step 3 is intracranial pressure by Lumbar catheter pressure monitoring module Lumbar catheter pressure monitoring, the directly variation of reaction intracranial pressure The invasive monitoring means of power, for being not suitable for non-invasive monitoring or needing the operation of successive reaction pressure change;It is integrated by information Module integrated data are shown for information, information stores and integrates with information;
Step 4, information display screen provide vital signs in real time, arterial pressure, depth of anesthesia, bilateral intraocular pressure and Lumbar catheter Pressure value is fitted intraocular pressure rate of change after integration, and provides each numerical value and time curve;Based on intraocular The linear relationship of pressure and intracranial pressure reflects the variation of intracranial pressure by the measurement to intraocular pressure indirectly, is applied to general anesthesia patients mesocrany Inspection of inner pressure.
4. the monitoring method based on intraocular pressure and intracranial pressure linear relationship described in a kind of operation claim 1 based on intraocular pressure and The monitoring system of intracranial pressure linear relationship, which is characterized in that the monitoring system based on intraocular pressure and intracranial pressure linear relationship Include:
Information for being integrated to detection information integrates module;
For measuring the measure of intraocular pressure module of intraocular pressure;
Vital sign monitoring modular for being monitored to vital sign;
Lumbar catheter pressure monitoring module for Lumbar catheter pressure monitoring;
It is mutual that the measure of intraocular pressure module, vital sign monitoring modular, Lumbar catheter pressure monitoring module and information integrate module Independent connection.
5. the monitoring system based on intraocular pressure and intracranial pressure linear relationship as claimed in claim 4, which is characterized in that the life Ordering sign monitoring modular includes:
Electrocardiogram monitoring unit for being monitored to heart;
The wound arterial pressure monitoring unit that blood pressure is monitored;
The double frequency eeg monitoring unit that brain states are monitored.
6. a kind of monitoring method realized based on intraocular pressure and intracranial pressure linear relationship described in claims 1 to 3 any one Computer program.
7. a kind of monitoring method realized based on intraocular pressure and intracranial pressure linear relationship described in claims 1 to 3 any one Information data processing terminal.
8. a kind of computer readable storage medium, including instruction, when run on a computer, so that computer is executed as weighed Benefit requires the monitoring method described in 1-3 any one based on intraocular pressure and intracranial pressure linear relationship.
CN201811186706.6A 2018-10-12 2018-10-12 A kind of monitoring system and method based on intraocular pressure and intracranial pressure linear relationship Pending CN109124567A (en)

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Application publication date: 20190104