CN109119178B - Lead box for storing radioactive isotope medicines - Google Patents
Lead box for storing radioactive isotope medicines Download PDFInfo
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- CN109119178B CN109119178B CN201811231154.6A CN201811231154A CN109119178B CN 109119178 B CN109119178 B CN 109119178B CN 201811231154 A CN201811231154 A CN 201811231154A CN 109119178 B CN109119178 B CN 109119178B
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- barrel body
- pipe
- inner barrel
- lead
- cover
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- 239000003814 drug Substances 0.000 title claims abstract description 30
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 18
- 229940079593 drug Drugs 0.000 title claims description 9
- 230000007246 mechanism Effects 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000009423 ventilation Methods 0.000 claims abstract description 9
- 239000000839 emulsion Substances 0.000 claims description 19
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims description 16
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 239000002131 composite material Substances 0.000 claims description 13
- 238000007334 copolymerization reaction Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 10
- 239000003973 paint Substances 0.000 claims description 9
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 8
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 8
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 239000003822 epoxy resin Substances 0.000 claims description 7
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 claims description 7
- 229920000647 polyepoxide Polymers 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 7
- 239000002518 antifoaming agent Substances 0.000 claims description 6
- 239000002270 dispersing agent Substances 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 230000005855 radiation Effects 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 239000012217 radiopharmaceutical Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000003999 initiator Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 229940121896 radiopharmaceutical Drugs 0.000 claims description 3
- 230000002799 radiopharmaceutical effect Effects 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000002519 antifouling agent Substances 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 abstract description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 6
- 239000001301 oxygen Substances 0.000 abstract description 6
- 229910052760 oxygen Inorganic materials 0.000 abstract description 6
- 230000001681 protective effect Effects 0.000 abstract description 4
- 238000005070 sampling Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000013016 damping Methods 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000003141 isotope labeling method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/06—Details of, or accessories to, the containers
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Sampling And Sample Adjustment (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to the technical field of medicine storage, and discloses a radioactive isotope medicine storage lead box which comprises an outer barrel body, an inner barrel body, a lifting mechanism and a ventilation mechanism, wherein the outer barrel body comprises an outer barrel body and an outer barrel cover; the lifting mechanism is arranged at the bottom of the accommodating cavity, and the inner barrel body is arranged in the accommodating cavity and is arranged on the lifting mechanism; the air exchange mechanism comprises an outer pipe and an inner pipe, and the outer pipe and the inner pipe are both annular pipes and are respectively arranged in the outer barrel body; the outer pipe is provided with an air inlet pipe and an air exhaust pipe, the outer pipe is communicated with the inner pipe through a plurality of connecting pipes, the inner pipe is provided with a plurality of air outlet pipes, and the air outlet pipes are communicated with the accommodating cavity; the lead box has small volume and convenient sampling, can replace water vapor, oxygen, corrosive gas and the like in the box body, and is filled with protective gas to prolong the storage time of the medicine.
Description
Technical Field
The invention relates to the technical field of medicine storage, in particular to a radioactive isotope medicine storage lead box.
Background
Isotopes are elements in which the number of protons of two atoms is the same, but the number of neutrons is different, and the atoms have the same atomic order and are in the same position in a periodic table; isotopes fall into two categories, one of which is radioactive and is called a "radioisotope"; another class is that without radioactivity and with a half-life greater than 1050 years, called "stable isotopes". The radioactive isotope is applied to an isotope labeling method which is widely applied in the fields of biochemistry and molecular biology, and plays an extremely important role in revealing the secrecy of physicochemical processes in vivo and cells and clarifying the material basis of life activities.
The atomic nucleus of the radioactive isotope is unstable, can uninterruptedly and spontaneously emit rays, directly contacts with a human body, and has great harm. Therefore, the medicines made of the radioactive isotopes need to be put into a device with radiation protection function, and lead boxes, lead cans and the like are commonly used; the existing lead box has large volume and is inconvenient for taking and placing samples; meanwhile, water vapor or oxygen, corrosive gas and the like in the air cannot be well isolated, the medicine is easy to absorb moisture and deteriorate, and the quality of the medicine cannot be guaranteed.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a radioactive isotope medicine storage lead box which is small in size and convenient to sample, can replace water vapor, oxygen, corrosive gas and the like in a box body, and is filled with protective gas to prolong the storage time of medicines.
In order to achieve the above purpose, the invention provides the following technical scheme:
a radioactive isotope medicine storage lead box comprises an outer barrel body, an inner barrel body, a lifting mechanism and a ventilation mechanism, wherein the outer barrel body comprises an outer barrel body and an outer barrel cover; the lifting mechanism is arranged at the bottom of the accommodating cavity, and the inner barrel body is arranged in the accommodating cavity and is arranged on the lifting mechanism; the air exchange mechanism comprises an outer pipe and an inner pipe, wherein the outer pipe and the inner pipe are both annular pipes and are respectively arranged in the outer barrel body; the outer pipe is provided with an air inlet pipe and an air exhaust pipe, the outer pipe is communicated with the inner pipe through a plurality of connecting pipes, the inner pipe is provided with a plurality of air outlet pipes, and the air outlet pipes are communicated with the accommodating cavity.
In the invention, preferably, the lifting mechanism comprises an electric push rod and a lifting cover, the electric push rod is fixedly arranged at the bottom of the accommodating cavity, and the output end of the electric push rod is fixedly connected with the lifting cover; the inner diameter of the lifting cover is equal to or slightly larger than the outer diameter of the inner barrel body, and the inner barrel body can be arranged in the lifting cover.
In the present invention, preferably, a damping device is provided in the lift cap.
In the invention, preferably, the inner barrel body comprises an inner barrel body, an inner barrel cover and a lofting device; the inner barrel cover is used for opening or closing the inner barrel body; the lofting device is arranged on the sample box and the fixing column, external threads are arranged on the fixing column, a groove is arranged on the inner barrel body, internal threads matched with the external threads on the fixing column are arranged in the groove, and the lofting device and the fixing column are in threaded connection and used for fixing the lofting device.
In the invention, preferably, the inner barrel body and the inner barrel cover are made of lead, and the outer surface of the inner barrel body and the inner surface of the outer barrel body are coated with radiation-proof coating.
In the present invention, preferably, the radiation protection paint comprises, by weight: 40.0-48.0% of quaternary copolymer emulsion, 5.0-10.0% of epoxy resin, 20.0-35.0% of composite radiation-proof material, 1.0-10.0% of pigment, 0.8-2.5% of wetting dispersant, 0.1-0.5% of neutralizer, 0.1-0.5% of defoaming agent, 0.1-0.5% of preservative, 0.1-3.0% of thickening agent, 1.0-5.0% of film-forming additive and 0.1-32.0% of water.
In the present invention, preferably, the quaternary copolymerization emulsion comprises the following components in percentage by weight: 18-20% of styrene, 24-25% of butyl acrylate, 6-7% of ethyl acrylate, 0.5-1% of acrylic acid and 48-50% of water; the preparation method of the quaternary copolymerization emulsion comprises the following steps: adding styrene, butyl acrylate, ethyl acrylate, acrylic acid, an emulsifier and an initiator into a reaction kettle according to a ratio, starting stirring, and uniformly mixing the components for later use; adding water into another reaction kettle, slowly dripping the mixed solution prepared by the reaction kettle when the temperature of the water in the reaction kettle is raised to 80 ℃, controlling the dripping time to be about 200-240min, continuing stirring and preserving the temperature for 60 min after finishing dripping, and then cooling, post-treating, vacuumizing and discharging to prepare the quaternary copolymerization emulsion.
In the invention, preferably, the composite radiation-proof material comprises the following components in percentage by weight: 75-82% of lead powder and 18-25% of coumarone resin.
In the present invention, it is preferable that the tub cover is provided with a gasket.
Compared with the prior art, the invention has the beneficial effects that:
(1) The radioactive isotope medicine storage lead box comprises an outer barrel body, an inner barrel body, a lifting mechanism and a ventilation mechanism, wherein the lifting mechanism is arranged to facilitate a user to take and place radioactive isotope medicines; meanwhile, the air exchange mechanism replaces water vapor, oxygen, corrosive gas and the like in the lead box, and protective gas is filled, so that the moisture absorption or deterioration of the medicine can be effectively prevented, and the storage time of the medicine is greatly prolonged.
(2) The radioactive isotope medicine storage lead box comprises an outer barrel body and an inner barrel body, wherein the inner barrel body is made of lead, and the outer surface of the inner barrel body and the inner surface of the outer barrel body are coated with radiation-proof coating, so that the radioactive isotope medicine storage lead box has a better radiation-proof effect due to multi-layer protection, and the health of a user is effectively protected; the novel radiation-proof coating prepared by using the quaternary copolymerization emulsion, the epoxy resin and the composite radiation-proof material as main materials has a good radiation-proof effect, and the emulsion formed by the quaternary copolymerization emulsion and the epoxy resin has high viscosity and high hardness; the lead layer of the inner barrel can be thinner or the outer barrel body is made of copper, iron or alloy; therefore, the lead box can be made smaller and is easy to transport and carry.
Drawings
Fig. 1 is a schematic structural view of a lead storage case for a radiopharmaceutical injection according to a preferred embodiment of the present invention.
Fig. 2 is a sectional view of the radioactive isotope medicine storage lead case in this embodiment.
Fig. 3 is a plan view of the ventilation mechanism in the radiopharmaceutical storage lead case of this embodiment.
Fig. 4 is a front view of the lofting apparatus in the radiopharmaceutical storage pig of this embodiment.
The main elements in the drawings are illustrated by symbols: 1-outer barrel body, 101-outer barrel body, 102-outer barrel cover, 103-containing cavity, 2-inner barrel body, 21-inner barrel body, 22-inner barrel cover, 23-lofting device, 231-sample box, 2311-sample groove, 232-fixed column, 3-lifting mechanism, 31-electric push rod, 32-lifting cover, 4-ventilation mechanism, 41-outer tube, 411-air inlet tube, 412-air exhaust tube, 42-inner tube, 421-air outlet tube, 43-connecting tube and 5-valve.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1: referring to fig. 1 to 4, the present embodiment provides a radioisotope medicine storage lead box, where the lead box includes an outer barrel body 1, an inner barrel body 2, a lifting mechanism 3 and a ventilation mechanism 4, the outer barrel body 1 includes an outer barrel body 101 and an outer barrel cover 102, an accommodating cavity 103 is disposed in the outer barrel body 101, and the outer barrel cover 102 is used to open or close the accommodating cavity 103; further, the outer barrel body 101 is a lead barrel, and a sealing ring is arranged on the outer barrel cover 102, so that the sealing effect of the outer barrel body 101 is better; in this embodiment, the inner tub 2 includes an inner tub body 21, an inner tub cover 22, and a lofting device 23; the inner barrel cover 22 is used for opening or closing the inner barrel body 21; the lofting device 23 is arranged on the sample box 231 and the fixing column 232, an external thread is arranged on the fixing column 232, a groove is arranged on the inner barrel body 21, an internal thread matched with the external thread on the fixing column 232 is arranged in the groove, and the lofting device 23 and the fixing column are in threaded connection and used for fixing the lofting device 23 and fixing medicines. Further, the inner barrel body 21 and the inner barrel cover 22 are made of lead.
The lifting mechanism 3 is arranged at the bottom of the accommodating cavity 103, and the inner barrel body 2 is arranged in the accommodating cavity 103 and is arranged on the lifting mechanism 3; the ventilation mechanism 4 comprises an outer tube 41 and an inner tube 42, and the outer tube 41 and the inner tube 42 are both annular tubes and are respectively arranged in the outer barrel body 101; an air inlet pipe 411 and an air exhaust pipe 412 are arranged on the outer pipe 41, the outer pipe 41 is communicated with the inner pipe 42 through a plurality of connecting pipes 43, a plurality of air outlet pipes 421 are arranged on the inner pipe 42, and the air outlet pipes 421 are communicated with the accommodating cavity 103; the air inlet pipe 411, the air exhaust pipe 412 and the connecting pipe 43 are all provided with a valve 5; the air exchange mechanism 4 is used for replacing water vapor, oxygen, corrosive gas and the like in the lead box and is filled with protective gas, so that the moisture absorption or deterioration of the medicine can be effectively prevented, and the storage time of the medicine is greatly prolonged.
In this embodiment, the outer surface of the inner barrel body and the inner surface of the outer barrel body are coated with radiation-proof paint; the radiation-proof paint comprises the following components in percentage by weight: 40.0 percent of quaternary copolymer emulsion, 5.0 percent of epoxy resin, 20.0 percent of composite radiation-proof material, 1.0 percent of pigment, 0.8 percent of wetting dispersant, 0.1 percent of neutralizer, 0.1 percent of defoaming agent, 0.1 percent of preservative, 0.1 percent of thickening agent, 1.0 percent of film-forming additive and 31.8 percent of water.
In this embodiment, the quaternary copolymerization emulsion comprises the following components in percentage by weight: 18% of styrene, 25% of butyl acrylate, 7% of ethyl acrylate, 0.5% of acrylic acid and 50% of water; the composite radiation-proof material comprises the following components in percentage by weight: 75% of lead powder and 25% of coumarone resin.
Example 2: referring to fig. 1 to 4, the present embodiment provides a lead storage box for a radioisotope medicine, which is different from embodiment 1 in that: the lifting mechanism 3 comprises an electric push rod 31 and a lifting cover 32, the electric push rod 31 is fixedly arranged at the bottom of the accommodating cavity 103, and the output end of the electric push rod 31 is fixedly connected with the lifting cover 32; the electric push rod 31 is externally connected with a power supply and is provided with a control switch, and the control switch can control the electric push rod 31 to be in a power-on or power-off state; the internal diameter of lifting cover 32 equals or slightly is greater than the external diameter of interior staving 2, interior staving 2 can be arranged in lifting cover 32, under electric putter 31's effect, drives lifting cover 32 and reciprocates to drive interior staving 2 and reciprocate, be convenient for get and put the sample. Further, lift and be equipped with damping device 321 in the cover 32, damping device 321 is the spring, and in the deformation range of spring, can prevent that the sample from damaging including the buffering that staving 2 rocked.
In this embodiment, the outer surface of the inner barrel body and the inner surface of the outer barrel body are coated with radiation-proof paint; the radiation-proof paint comprises the following components in percentage by weight: 43.0% of quaternary copolymer emulsion, 8.0% of epoxy resin, 30.0% of composite radiation-proof material, 3.0% of pigment, 1.2% of wetting dispersant, 0.2% of neutralizing agent, 0.25% of defoaming agent, 0.25% of preservative, 0.5% of thickening agent, 1.2% of film-forming additive and 12.4% of water.
In this embodiment, the quaternary copolymerization emulsion comprises the following components in percentage by weight: 19% of styrene, 24% of butyl acrylate, 7% of ethyl acrylate, 0.7% of acrylic acid and 50% of water; the composite radiation-proof material comprises the following components in percentage by weight: 80% of lead powder and 20% of coumarone resin.
Example 3: referring to fig. 1 to 4, the present embodiment provides a lead box for storing a radioisotope, which is different from embodiments 1 and 2 in that: the outer surface of the inner barrel body and the inner surface of the outer barrel body are coated with radiation-proof paint; the radiation-proof paint comprises the following components in percentage by weight: 48.0 percent of quaternary copolymer emulsion, 8.0 percent of epoxy resin, 32.0 percent of composite radiation-proof material, 1.0 percent of pigment, 2.0 percent of wetting dispersant, 0.5 percent of neutralizing agent, 0.5 percent of defoaming agent, 0.5 percent of preservative, 0.1 percent of thickening agent, 5.0 percent of film-forming additive and 2.4 percent of water.
In this embodiment, the quaternary copolymerization emulsion comprises the following components in percentage by weight: 20% of styrene, 25% of butyl acrylate, 7% of ethyl acrylate, 1% of acrylic acid and 48% of water; the composite radiation-proof material comprises the following components in percentage by weight: 82% of lead powder and 18% of coumarone resin.
The preparation method of the radiation-proof coating comprises the following steps: 1) Preparing quaternary copolymerization emulsion: adding styrene, butyl acrylate, ethyl acrylate, acrylic acid, an emulsifier and an initiator into a reaction kettle according to a ratio, starting stirring, and uniformly mixing for later use; adding water into the other reaction kettle, slowly dropwise adding the mixed solution prepared by the reaction kettle when the temperature of the water in the reaction kettle is raised to 80 ℃, controlling the dropwise adding time to be about 200-240min, continuously stirring and preserving heat for 60 min after the dropwise adding is finished, and then starting cooling, post-treatment, vacuumizing and discharging to prepare quaternary copolymer emulsion;
2) Preparing a composite radiation-proof material: preheating a reaction tank to 60 ℃ by using an electric furnace, adding the solid coumarone resin in the proportion, slowly heating until the solid coumarone resin is molten, then adding the lead powder in the corresponding proportion, stirring at constant temperature, continuing stirring for 10-15 minutes after the solid coumarone and the lead powder are uniformly mixed, cooling to room temperature, and preparing into particles by using a crushing process to obtain the composite radiation-proof material;
3) Preparing the radiation-proof paint: uniformly mixing the wetting dispersant, the neutralizer, one third of the defoaming agent, one half of the preservative, the pigment and the radiation-proof material, and adding a proper amount of water; grinding the mixture until the fineness is less than 50 mu m; slowly adding the rest components at stirring speed of 600-800 rpm, and stirring and mixing uniformly.
The working principle is as follows: firstly, placing a radioactive sample into the sample box 231, and connecting the lofting device 23 with the inner barrel body 21 through the fixing column 232; the inner barrel body 2 is placed into the lifting cover 32, the electric push rod 31 is started to drive the lifting cover 32 to move up and down so as to drive the inner barrel body 2 to move up and down to a proper position, and the inner barrel cover 22 and the outer barrel cover 102 are covered; then, the air inlet pipe 411 is externally connected with a nitrogen filling device, the air exhaust pipe 412 is externally connected with an air exhaust device, and the connecting pipe 43 and the valve 5 on the air inlet pipe 411 are rotated to seal the corresponding pipeline; opening the valve 5 on the exhaust pipe 412 and starting the exhaust device to make the outer pipe 41 in a vacuum state or a state close to the vacuum state; closing the air extractor and closing the valve 5 on the air extracting pipe 412, and simultaneously opening the nitrogen filling device and the valve 5 on the air inlet pipe 411 to fill the outer pipe 41 with nitrogen; the nitrogen filling device is closed, the valve 5 on the air inlet pipe 411 is closed, the valve 5 on the connecting pipe 43 is opened, nitrogen in the outer pipe 41 enters the inner pipe from the air outlet pipe 42 to the inner through body 2 through the connecting pipe 43, after air exchange, air exchange is repeated for 5-10 times, the air exchange is completed in this way, samples in the device 23 cannot be put out, the nitrogen is filled, water vapor, oxygen, corrosive gas and the like in the lead box are replaced, moisture absorption or deterioration of the medicines can be effectively prevented, and the storage time of the medicines is greatly prolonged. Meanwhile, compared with the common lead barrel, the lead barrel prepared by the detection examples 1-3 achieves the same radiation protection effect, and the quality of the lead barrel is only 89.2%, 90.2% and 90.8% of the quality of the common lead barrel; therefore, the lead box can be made to be smaller and is easy to transport and carry.
The above description is for the purpose of illustrating the preferred embodiments of the present invention, but the present invention is not limited thereto, and all changes and modifications that can be made within the spirit of the present invention should be included in the scope of the present invention.
Claims (8)
1. The radioactive isotope medicine storage lead box is characterized by comprising an outer barrel body (1), an inner barrel body (2), a lifting mechanism (3) and a ventilation mechanism (4), wherein the outer barrel body (1) comprises an outer barrel body (101) and an outer barrel cover (102), a containing cavity (103) is formed in the outer barrel body (101), and the outer barrel cover (102) is used for opening or closing the containing cavity (103); the lifting mechanism (3) is arranged at the bottom of the accommodating cavity (103), and the inner barrel body (2) is arranged in the accommodating cavity (103) and is arranged on the lifting mechanism (3);
the ventilation mechanism (4) comprises an outer pipe (41) and an inner pipe (42), wherein the outer pipe (41) and the inner pipe (42) are both annular pipes and are respectively arranged in the outer barrel body (101); an air inlet pipe (411) and an air exhaust pipe (412) are arranged on the outer pipe (41), the outer pipe (41) is communicated with the inner pipe (42) through a plurality of connecting pipes (43), a plurality of air outlet pipes (421) are arranged on the inner pipe (42), and the air outlet pipes (421) are communicated with the accommodating cavity (103);
the inner barrel body (2) comprises an inner barrel body (21) and an inner barrel cover (22), and radiation-proof paint is coated on the outer surface of the inner barrel body (21) and the inner surface of the outer barrel body (101);
the radiation-proof coating comprises, by weight, 40.0-48.0% of quaternary copolymer emulsion, and the quaternary copolymer emulsion comprises the following components: 18-20% of styrene, 24-25% of butyl acrylate, 6-7% of ethyl acrylate, 0.5-1% of acrylic acid and 48-50% of water; the preparation method of the quaternary copolymerization emulsion comprises the following steps: adding styrene, butyl acrylate, ethyl acrylate, acrylic acid, an emulsifier and an initiator into a reaction kettle according to a ratio, starting stirring, and uniformly mixing the components for later use; adding water into another reaction kettle, slowly dripping the mixed solution prepared by the reaction kettle when the temperature of the water in the reaction kettle is raised to 80 ℃, controlling the dripping time to be about 200-240min, continuing stirring and preserving the temperature for 60 min after finishing dripping, and then cooling, post-treating, vacuumizing and discharging to prepare the quaternary copolymerization emulsion.
2. A radioisotope medicine storage lead box as claimed in claim 1, wherein said lifting mechanism (3) comprises an electric push rod (31) and a lifting cover (32), said electric push rod (31) is fixedly installed at the bottom of said containing cavity (103), and its output end is fixedly connected to said lifting cover (32); the inner diameter of the lifting cover (32) is equal to or slightly larger than the outer diameter of the inner barrel body (2), and the inner barrel body (2) can be placed in the lifting cover (32).
3. A radioisotope pharmaceutical storage lead case as claimed in claim 2, wherein said lift cap (32) is provided with a shock absorbing means (321).
4. A radioisotope pharmaceutical storage lead box as claimed in any one of claims 1 to 3, wherein said inner barrel body (2) further comprises lofting means (23); the inner barrel cover (22) is used for opening or closing the inner barrel body (21); the lofting device (23) is arranged on the sample box (231) and the fixing column (232), an external thread is arranged on the fixing column (232), a groove is arranged on the inner barrel body (21), an internal thread matched with the external thread on the fixing column (232) is arranged in the groove, and the lofting device and the inner barrel body are in threaded connection and used for fixing the lofting device (23).
5. The lead storage box of claim 4, wherein the inner barrel body (21) and the inner barrel cover (22) are made of lead.
6. A lead storage box for radioactive isotope medicines in accordance with claim 5, wherein said radiation protective paint further comprises, in terms of weight percentage: 5.0-10.0% of epoxy resin, 20.0-35.0% of composite radiation-proof material, 1.0-10.0% of pigment, 0.8-2.5% of wetting dispersant, 0.1-0.5% of neutralizer, 0.1-0.5% of defoaming agent, 0.1-0.5% of preservative, 0.1-3.0% of thickening agent, 1.0-5.0% of film-forming assistant and 0.1-32.0% of water.
7. A radioisotope pharmaceutical storage lead box as claimed in claim 6, wherein said composite radiation shielding material comprises the following components in percentage by weight: 75-82% of lead powder and 18-25% of coumarone resin.
8. A radiopharmaceutical storage pig as set forth in claim 1 wherein said outer lid (102) is provided with a sealing ring.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811231154.6A CN109119178B (en) | 2018-10-22 | 2018-10-22 | Lead box for storing radioactive isotope medicines |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811231154.6A CN109119178B (en) | 2018-10-22 | 2018-10-22 | Lead box for storing radioactive isotope medicines |
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| Publication Number | Publication Date |
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| CN109119178A CN109119178A (en) | 2019-01-01 |
| CN109119178B true CN109119178B (en) | 2022-12-06 |
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| CN201811231154.6A Active CN109119178B (en) | 2018-10-22 | 2018-10-22 | Lead box for storing radioactive isotope medicines |
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| CN113066596A (en) * | 2021-03-23 | 2021-07-02 | 中国原子能科学研究院 | Radioactive sample storage device |
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| CN109119178A (en) | 2019-01-01 |
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Denomination of invention: A lead box for storing radioactive isotope drugs Granted publication date: 20221206 Pledgee: Bohai Bank Co.,Ltd. Tianjin Branch Pledgor: TIANJIN WANMU RADIATION PROTECTIVE ENGINEERING Co.,Ltd. Registration number: Y2024120000043 |