CN109106937A - Application of the wood frog's fallopian tube collagen peptide in eczema is antipruritic - Google Patents

Application of the wood frog's fallopian tube collagen peptide in eczema is antipruritic Download PDF

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Publication number
CN109106937A
CN109106937A CN201810741828.0A CN201810741828A CN109106937A CN 109106937 A CN109106937 A CN 109106937A CN 201810741828 A CN201810741828 A CN 201810741828A CN 109106937 A CN109106937 A CN 109106937A
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fallopian tube
wood frog
collagen peptide
eczema
tube collagen
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邱芳萍
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/65Amphibians, e.g. toads, frogs, salamanders or newts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of application of wood frog's fallopian tube collagen peptide in eczema is antipruritic, and wood frog's fallopian tube collagen peptide is used for zoopery and eczema 200 many cases of antipruritic treatment of people, as a result prove there is antipruritic effect.

Description

Application of the wood frog's fallopian tube collagen peptide in eczema is antipruritic
Technical field
The present invention relates to a kind of medical field, in particular to application of a kind of wood frog's fallopian tube collagen peptide in eczema is antipruritic.
Background technique
Phase eczema is a kind of hypersensitive inflammation skin disease, is a kind of common disease, and the cause of disease is complicated, eczema symptom it is wet out Rash pathogenesis is related with IV allergic reaction type, i.e., delayed allergy (the Delayed Type mediated by T lymphocyte Of Hypersensitivity, DTH), it is often the interaction of inside and outside many factors as a result, general relatively rapid, fash of falling ill It in pleomorphism, is made of papule, erythema and bubble, edge diffuses unclear, violent itch, can be by acute, subacute recurrent exerbation It is transformed into chronic eczema, shows as pachylosis, scratch, incrustation, has seriously affected the quality of life of patient, also resulted in patient Psychological pressure.
The generation of eczema is the influence of internal and external environment, and the moisturizing mechanism of skin receives destruction and damages initiation, skin Moisture content between skin tissue cell and cell is reduced, and causes cell arrangement close, the collagen dehydration hardening in skin, When the moisture in the outermost cuticula of skin is reduced to 10% or less, skin show dry, matt and slip, corrugation, Rough surface, flakiness, at this point, by the influence such as external environment, virus, bacterium, sunshine or the thorn of body something itself Scytitis will be induced by swashing, and exactly this inflammation leads to red swelling of the skin, itch even pain.The water conservation moisturizing of skin is always The research topic that skin protection cosmetics does not wane always, research and excavation can improve the soft and moist property of skin biology, slickness and water conservation and protect Wet material is the basic condition for preventing and treating skin disease.
Summary of the invention
The present invention provides a kind of application of wood frog's fallopian tube collagen peptide in eczema is antipruritic, is found through experiments that, wood frog's fallopian tube collagen Protein peptides have antipruritic effect to eczema.
Wood frog's fallopian tube collagen peptide has the mechanism of antipruritic effect to eczema:
Wood frog's fallopian tube collagen peptide is to repair collagen type, is play in the health and beauty of human skin very important Role.Using technologies such as advanced orientation digestion, UF membrane, spray drying, extractions, the product extracted from collagen, The average molecular weight of wood frog's fallopian tube collagen peptide is in 3500Da or so, the three-level superhelix of opposite collagen complexity, wood frog's fallopian tube collagen The linear structure of peptide makes its digestibility be up to 80%.Wood frog's fallopian tube collagen peptide is the hydrolysate of collagen, is that the minimum of collagen is single Member, structure can be expressed as (Gly-x-y), be a kind of high-purity peptide that glycine is had in N-terminal, can be by without decomposing Absorption of human body and utilization.The component polypeptides that people are called bombesin are mainly contained in wood frog's fallopian tube skin, it have anti-inflammatory, anticancer, Anti-aging and other effects;Wood frog's fallopian tube skin not easy infection, the features such as self-healing speed is fast, repair ability is strong after injury, all and in skin Contained active peptide is related.Therefore, for the research of its active peptide, the development that can be used for novel functional food and drug is opened Hair has application value and realistic meaning.
Antibacterial peptide can not only inhibit certain proinflammatories, while can also enhance certain other immune responses.Antibacterial peptide pair The adjusting or regulation of function have apparent paradox in immune response.This characteristic that these peptides are shown in inflammatory environment Be conducive to selectively inhibit or promote the overall balance of inflammatory reaction in host, to generate a kind of appropriate, pure resist Infection reaction.The immunoloregulation function that antibacterial peptide is mediated be not independently of other immune responses, but formed a complexity Immune mediator network and downstream signaling pathway, this is also necessary to defense mechanism entirety effective operation.In same antibacterial peptide phase During interaction, they activate the key signal access that innate immunity gene function in downstream is adjusted with adjusting to some extent.It is anti- Bacterium peptide can directly affect the activation of transcription factor, participate in the adjusting and expression of congenital immunity gene, meet functional genomics Research.
Wood frog's fallopian tube collagen peptide can more effectively penetrate into cuticula, skin corium, effectively with its unique natural performance Play the role of moisturizing, water conservation and water lock, plays and extend the Skin Cell service life, inhibit Cell membrane lipids peroxidating, resist oxidation Free radical is to the attack of DNA, the activity for inhibiting tyrosine, raising cutaneous immunisation ability, raising skin water holding water holding capacity, promotion The multiple efficacies such as the synthesis of collagen and the synthesis of dermal cell hyaluronic acid.
Detailed description of the invention
Fig. 1 is that 0.05g/kg antipruritic effect comparison diagram is once a day administered in wood frog's fallopian tube collagen peptide cream.
Fig. 2 is the mouse delayed that the high, medium and low dosage group of wood frog's fallopian tube collagen peptide cream induces 2,4-dinitrochlorobenzene The comparison diagram that hypersensitivity (ear swelling) significantly inhibits.
Specific embodiment
Three formulas based on wood frog's fallopian tube collagen peptide carry out zoopery below, verify wood frog's fallopian tube collagen peptide to wet The antipruritic effect of rash:
Wood frog's fallopian tube collagen peptide paste ingredient 1, mass percent:
Stearic acid 7%, single glycosides rouge 6%, propylene glycol 5%, glycerine 8%, potassium hydroxide 0.5%, P-hydroxybenzoic acid first Ester 0.02%, wood frog's fallopian tube collagen peptide 1.5%, deionized water 71.98%.
Wood frog's fallopian tube collagen peptide paste ingredient 2, mass percent:
Glycerin monostearate 10%, single glycosides rouge 3%, octadecyl alcolol 4%, glycerine 9%, emulsifier HR-SL (alkyl phosphorus Acid esters sylvite) 0.5%, oviductus ranae 1%, methyl p-hydroxybenzoate 0.01%, ethyl-para-hydroxybenzoate 0.01%, wood frog's fallopian tube glue Former protein peptides 1.5%, distilled water 70.98%.
Wood frog's fallopian tube collagen peptide paste ingredient 3, mass percent:
Hydrogenate oneself 4%, glycerine 9%, panaxoside 1.5%, cream of soft phosphatide 8.5%, single glycosides rouge 5%, palm acid ethyl Agent HR-SL (potassium alkyl phosphate) 0.5%, methyl p-hydroxybenzoate 0.01%, propylparaben 0.005%, ethyl-para-hydroxybenzoate 0.005%, wood frog's fallopian tube collagen peptide 1.5%, distilled water 69.98%.
Wood frog's fallopian tube collagen peptide paste ingredient 1, formula 2 and the animal experiment for being formulated 3
Wood frog's fallopian tube collagen peptide cream, which is once a day administered, is remarkably improved the threshold value that histamine phosphate causes cavy itch, wherein with It is best that wood frog's fallopian tube collagen peptide cream is once a day administered 0.05g/kg antipruritic effect, the results are shown in Table 1 and Fig. 1.
Table 1: influence of the wood frog's fallopian tube collagen peptide to cavy itch-threshold
Note: P < 0.01 * * compared with blank group
The mouse delayed that the high, medium and low dosage group of wood frog's fallopian tube collagen peptide cream induces 2,4-dinitrochlorobenzene is super quick Reaction (ear swelling) significantly inhibit, can substantially reduced allergic inflammation symptom, the results are shown in Table 2 and Fig. 2.
Table 2: the influence that wood frog's fallopian tube collagen peptide swells to mouse ear
Note: P < 0.01 * P < 0.05 compared with model control group, * *.
By above it is demonstrated experimentally that wood frog's fallopian tube collagen peptide has antipruritic effect to eczema.
In addition, wood frog's fallopian tube collagen peptide paste ingredient 1, formula 2 and formula 3 to be used for antipruritic 200 many cases of eczema of people, knot Fruit proves there is antipruritic effect.

Claims (4)

1. application of the wood frog's fallopian tube collagen peptide in eczema is antipruritic.
2. described in claim 1 using wood frog's fallopian tube collagen peptide paste, mass percent formula are as follows:
Stearic acid 7%, single glycosides rouge 6%, propylene glycol 5%, glycerine 8%, potassium hydroxide 0.5%, methyl p-hydroxybenzoate 0.02%, wood frog's fallopian tube collagen peptide 1.5%, deionized water 71.98%.
3. described in claim 1 using wood frog's fallopian tube collagen peptide paste, mass percent formula are as follows:
Glycerin monostearate 10%, single glycosides rouge 3%, octadecyl alcolol 4%, glycerine 9%, emulsifier HR-SL0.5%, oviductus ranae 1%, methyl p-hydroxybenzoate 0.01%, ethyl-para-hydroxybenzoate 0.01%, wood frog's fallopian tube collagen peptide 1.5%, distilled water 70.98%.
4. described in claim 1 using wood frog's fallopian tube collagen peptide paste, mass percent formula are as follows: hydrogenate soft phosphatide 8.5%, oneself 4%, glycerine 9% of single glycosides rouge 5%, palm acid ethyl, panaxoside 1.5%, emulsifier HR-SL 0.5%, right Methyl hydroxybenzoate 0.01%, propylparaben 0.005%, ethyl-para-hydroxybenzoate 0.005%, wood frog's fallopian tube collagen Protein peptides 1.5%, distilled water 69.98%.
CN201810741828.0A 2018-07-09 2018-07-09 Application of the wood frog's fallopian tube collagen peptide in eczema is antipruritic Pending CN109106937A (en)

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003176219A (en) * 2001-12-13 2003-06-24 Ichimaru Pharcos Co Ltd Collagen tripeptide-containing skin care preparation
CN101879307A (en) * 2009-05-08 2010-11-10 冒华 Preparation for repairing active cells
CN102229972A (en) * 2011-05-23 2011-11-02 长春工业大学 Preparation method for collagen peptides from tree frog skin
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CN101879307A (en) * 2009-05-08 2010-11-10 冒华 Preparation for repairing active cells
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CN102872158A (en) * 2012-07-02 2013-01-16 马应龙药业集团股份有限公司 External drug combination for curing eczema and preparation method thereof
CN104873479A (en) * 2015-05-19 2015-09-02 四川师范大学 Collagen polypeptide skin membrane capable of reducing swelling and relieving itching and preparation method of collagen polypeptide skin membrane
CN105919894A (en) * 2016-06-20 2016-09-07 合肥丰瑞隆生物科技有限公司 Biological environment-friendly liquid shampoo and preparing method thereof
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