CN109106737A - A kind of lyophilized excipient containing plant tissue - Google Patents
A kind of lyophilized excipient containing plant tissue Download PDFInfo
- Publication number
- CN109106737A CN109106737A CN201710490042.1A CN201710490042A CN109106737A CN 109106737 A CN109106737 A CN 109106737A CN 201710490042 A CN201710490042 A CN 201710490042A CN 109106737 A CN109106737 A CN 109106737A
- Authority
- CN
- China
- Prior art keywords
- plant tissue
- lyophilized excipient
- freeze
- sludge ice
- lyophilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 238000009472 formulation Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 53
- 239000010802 sludge Substances 0.000 claims description 37
- 210000001519 tissue Anatomy 0.000 claims description 28
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- -1 corrigent Substances 0.000 claims description 19
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- 238000000034 method Methods 0.000 claims description 15
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- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000001944 prunus armeniaca kernel oil Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Chemical class CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229930183339 qinghaosu Natural products 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- 229960002354 repaglinide Drugs 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- UELPQYXGRIZTHA-XSEBJXQCSA-N rotundin Chemical compound C1[C@H](O)\C(C)=C/[C@H]2OC(=O)C(=C)[C@@H]2[C@H](OC(=O)C(\C)=C/C)C[C@@]2(COC(C)=O)O[C@@H]21 UELPQYXGRIZTHA-XSEBJXQCSA-N 0.000 description 1
- 229960005224 roxithromycin Drugs 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 229960000953 salsalate Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930183842 salvianolic acid Natural products 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 229950009846 scopolamine butylbromide Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
- 229960000658 sumatriptan succinate Drugs 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- AEQDJSLRWYMAQI-KRWDZBQOSA-N tetrahydropalmatine Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-KRWDZBQOSA-N 0.000 description 1
- 229960002178 thiamazole Drugs 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical class Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 229960002872 tocainide Drugs 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Chemical class 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Chemical class 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Chemical class 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Chemical class 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Chemical class 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Chemical class 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
Classifications
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- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P30/00—Shaping or working of foodstuffs characterised by the process or apparatus
- A23P30/10—Moulding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/26—Aluminium; Compounds thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The present invention relates to a kind of lyophilized excipient containing plant tissue, especially a kind of includes plant tissue, and by being dissolved in water or formula solution, to obtain the formula and preparation method of a kind of product of formula solution containing plant tissue.
Description
Technical field
The present invention relates to a kind of lyophilized excipients containing plant tissue, and especially a kind of includes plant tissue, and is led to
It crosses and is dissolved in water or formula solution, to obtain formula and the preparation side of a kind of product of formula solution containing plant tissue
Method.
Background technique
In food, health food and cosmetics, the frequent visible product comprising plant tissue, such as comprising the drink of grain
Material, the toner comprising petal and bath product etc..But such mode due to be liquid preparation form, on the one hand for system
Stability need to be added a large amount of protective system, one side petal can also be lost in long period of soaking corresponding activity and nutrition at
Point, while this product form also has a higher logistics cost, is unfavorable for the transport of product.
Freeze-drying figuration technology refers to the addition skeleton supporting agent in the active constituent of flowable liquid, semisolid or solid
And itself contains binder and skeleton supporting agent in binder or the flowable liquid, semisolid or solid, then will
It is filled into molding die, is able to molding technology by freeze drying process, passes through the preparation of freeze-drying figuration technology preparation
Referred to as lyophilized excipient.
Since such preparation uses freeze drying process, it can protect labile active ingredient and be not destroyed, pass through simultaneously
Water sublimed generates a large amount of micropores and duct, can have cracking disintegration and solution rate, therefore receive extensive use, can
To be applied to the multiple fields such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics, medical instrument, health care product.
Inventor dedicates itself to innovation, and has carried out a large amount of in-depth studies and experiment work, based on lyophilized preparation manufacturing process
Principle carries out process optimization, and by the research to formula, provides a set of lyophilized excipient scheme that plant tissue is added,
Can guarantee that plant tissue had not only saved itself nutritional ingredient and active material, but can after encountering solvent fast rehydrating,
And the form of a product comprising plant tissue is formed, while its preparation and production process can't be in lyophilized excipients
On the basis of increase cost, and the scheme of logistics cost can be substantially reduced.
Summary of the invention
A kind of lyophilized excipient containing plant tissue, including binder and plant tissue.
The plant tissue can be fresh or pre-dry, whole strain of the position selected from plant, or spend,
One of stem, leaf, thallus, root, fruit, seed or multiple combinations.
The binder of the lyophilized excipient includes low temperature bonding agent and freeze-drying binder;The two weight ratio be (1:
100)~(100:1), it is 0.1mg/cm that weight, which accounts for the ratio between tablet volume,3-5000mg/cm3;The low temperature bonding agent is C1-
One of the alcohol of C16, grease, surfactant, high molecular polymer or multiple combinations;The freeze-drying binder be it is artificial or
Natural polymers, inorganic matter gelling agent, cellulose ethers, modified starch series, hyalomitome acids, albumin, dextrose
Acid anhydride, chitosan and its different molecular weight product, sodium alginate, PVP, PVA, polyethylene glycol, agar, polyaminoacid, glycan or it
Combination.
The alcohol of the C1-C6 be selected from propylene glycol, butanediol, glycerine, 1,2 butanediols, 1,2 propylene glycol, 1,3 butanediols,
One of pentanediol, polyethylene glycol, polyglycereol, diglycerol etc. are a variety of.
The grease is selected from dimethyl silicone polymer, eight stearate of polyglycereol -6, caprylic/capric triglyceride, glycerol
Three (thylhexoic acid) esters, diisooctadecanol malate, three isostearate of polyglycereol -2, dipentaerythritol three-poly- hydroxyl
Stearate, phytosterols oletate, vaseline, xanthan gum, glycerol three (behenic acid/isostearic acid/eicosane diacid) ester, lecithin
Rouge, hydrolecithin, Nexbase 2004, ethylhexyl methoxy cinnamate, cream, ermine oil, goose oil, dogfish oil, almond oil,
Apricot kernel oil, olive oil, sesame oil, tea-seed oil, ethylhexyl palmitate, Butyrospermum parkii fruit ester, lauric acid hexyl ester, carbonic acid two are pungent
One of ester, GTCC, sad Propylheptyl, oleyl alcohol or triglycerides etc. are a variety of.
The surfactant be selected from tween constituents, sapn constituents, PEG-20 glyceryl triisostearate, gather it is sweet
One of oily -10 distearates, -2 oleate of polyglycereol, cocounut oil acyl glycine potassium, lauroyl glycine potassium etc. are a variety of.
The high molecular polymer be sodium alginate, lanolin, agar, polyvinyl alcohol methyl acrylate graft copolymer,
Carbomer, carbomer, Sodium Hyaluronate, hyaluronic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, polyoxyethylene
One of alkene, modified paraffin, polyacrylamide, Sodium Polyacrylate, polyacrylate and polyacrylic acid and its derivative etc. or
It is a variety of.
The inorganic matter gelling agent is one of diatomite, bentonite, montmorillonite, Li-montmorillonite, Silica hydrogel or more
Kind.
The glue class binder is collagen, gelatin, gelatin hydrolysate, Arabic gum, xanthan gum, soybean protein glue, pyrenomycetes
Glue, biological carbohydrate gum, carrageenan, guar gum, gellan gum, pectin, konjac glucomannan, carrageenan, locust bean gum, natural gum, locust bean gum etc.
One of or it is a variety of.
The cellulose ethers binder is microcrystalline cellulose, carboxymethyl cellulose, carboxyethyl cellulose, ethoxy first
One of base cellulose, hydroxypropyl methyl cellulose etc. are a variety of.
The modified starch series binder is selected from Sodium Polyacrylate graft starch, pulullan, hydroxypropul starch, hydroxypropyl
One of methyl starch, pregelatinized starch, amylose, carboxymethyl starch, hydroxyethyl starch, hydroxypropul starch etc. are more
Kind.
The polyaminoacid is selected from one of polyglutamic acid, polyalanine, poly-aspartate, polylysine etc. or more
Kind.
The glycan is selected from one of fucoidin, synanthrin, glucan etc. or a variety of.
The lyophilized excipient can also further add active matter, skeleton supporting agent, and skin sense modifying agent is anti-oxidant
Agent, corrigent, essence, across one or more of mucous membrane, skin penetration enhancer and pH adjusting agent.
The active matter, independent be selected from is chemicals, Chinese medicine, natural extract, bioactive ingredients, skin nursing
One or more of beneficiating ingredient, disinfectant, oral diet supplementation and beautifying drug.
Chemicals (active pharmaceutical ingredient):
Antipyretic-antalgic anti-inflammatory agent, for example, aspirin, Diflunisal, salsalate, paracetamol, Indomethacin,
Brufen, naproxen, Ketoprofen, pirprofen, suprofen, Flurbiprofen, piroxicam, Meloxicam, aulin, benzene bromine horse
It is grand etc.;
Central stimulant, such as pemoline, adrafinil, Piracetam etc.;
Treat migraine agent, such as Sumatriptan succinate;
Antalgesic, such as rotundin, buprenorphine, pentazocine, naloxone etc.;
Anti-Parkinson's disease and treatment senile dementia medicine, such as levodopa, compound carbidopa, compound benserazide, hydrochloric acid
Amantadine, piribedil, phenolicamine, donepezil, huperzine are first-class;
Psychotolytic, such as chlorpromazine, fenazil, pethidine, thioridazine, Chlorprothixene, Clozapine, Shu Bi
Benefit, Tai Bili, penfluridol, Risperidone etc.;
Antiepileptic and anticonvulsive drug, such as dilantin sodium, carbamazepine, Primidone, Gabapentin, Lamotrigine, third
Natrium valericum, Clonazepam etc..
Hypnotic sedative agent, such as diazepam, nitrazepam, Oxazepam, Lorazepam, phenobarbital etc.;
Cholinesterase inhibitor, such as hyoscine etc.;
Antiarrhymic, such as third pyridine, tocainide, mexiletine, aetmozine, dilantin sodium, Propafenone, amine iodine
Ketone etc.;
Antianginal and antiatherosclerotic, such as Propranolol, nifedipine, Gemfibrozil, Bezafibrate, Lip river
Cut down statin, Simvastatin, Pravastatin etc.;
Antihypertensive, such as Enalapril, captopril, Hydrochioro, Amlodipine etc.;
Adrenoceptor blocking agents, such as acebutolol, alprenolol etc.;
Corticosteroid medicine, such as betamethasone, cortisone acetate etc.;
Antidiabetic, such as Repaglinide etc.;
Antithyroid drug, such as propylthiouracil (PTU), Carbimazole, methimazole etc.;
Antithistamine, such as Cetirizine Hydrochloride, Loratadine etc.;
Autacoid, such as dinoprostone, Alprostadil, Betahistine etc.;
Digestive system surgical procedures, such as scopolamine butylbromide, Granisetron Hydrochloride etc.;
Hematological system medicine, such as EPO, cobamamide etc.;
Urinary system medicine, such as azosemide, frusemide etc.;
Reproductive system medicine, such as estrogen, Nandrolone Phenylpropionate etc.;
Antiparasitic agent, such as albendazole, cambendazole etc.;
Antineoplastic, such as aminoglutethimide, amsacrine etc.;
Antimicrobial, such as ampicillin, sulbenicillin sodium etc.;
Tri-Biocin, such as Amoxicillin, cefalexin, Cefprozil, CEFUROXIME AXETIL, roxithromycin, amber second are red
Mycin, josamycin etc..
Traditional Chinese medicine ingredients:
Effective component of chinese medicine monomer, such as: Breviscapinun, qinghaosu, huperzine, tetrahydropalmatine;
Single medicinal material material extract and compound Chinese medicine extract, such as: tanshinone extract, is answered at salvianolic acid extract
Square Danshen Root dropping ball extract, cow-bezoar bolus compound extract, ginseng stem and leave general saponin, asiatic moonseed extract, general ginsenoside,
American ginseng total saponins, Breviscapinun, Glabrous Sarcandra Herb medicinal extract, arasaponin, capillary extract, extractum rhei, andrographolide, mountain
Short, bristly hair or beard leaf extract, asiaticoside, ginkgo biloba p.e etc..
Natural plant extracts:
As aloe extract, yam extract, Bilberry fruit P.E, Bitter Melon P.E, Echinacea Purpurea Herb P.E, feverfew are extracted
It is object, mangosteen extract, pine needle and Pine Bark, Brazilian blackberry extract, mulberries extract, elderberry extract, climing
More certain kind of berries extract, astaxanthin, lycopene, green-tea extract, grape pip and grape skin extract, glabridin, Paeoniflorin, sweet
Straw colour ketone, Cortex Moutan extract etc..
Bioactive ingredients:
It is EGF, bFGF, aFGF, KGF, IGF, NGF, TGF, HGH, EPO, G-CSF, GM-CSF, various antibody drugs, each
Kind vaccine, toxoid, antitoxin, various biological enzyme etc..
Skin nursing beneficiating ingredient:
Vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, vitamin
D, vitamin E, vitamin K, coenzyme class, protease, metallothionein, pearl and its hydrolysate, cow's milk and its extract, pollen
And its extract, royal jelly, propolis etc..
Disinfectant:
Liquid chlorine, potassium permanganate, ozone, hydrogen peroxide, chloramines, chlorine dioxide, Peracetic acid, 84 thimerosals, ethyl alcohol, lysol
That, phenol, cresols, formalin, merbromin, glutaraldehyde, bleaching powder, quaternary ammonium disinfectant (such as bromogeramine, geramine)
Deng.
Oral diet supplementation:
Amino acid, polyunsaturated fatty acid, minerals, vitamin, dietary ingredient, herbaceous plant, other plant components, or
Concentrate, extract or composition of the above ingredient etc..
Beautifying drug:
One of cosmetic material register of State Food and Drug Administration's publication is a variety of with beauty functions
Substance.
The skeleton agent is selected from sugared (such as maltose, trehalose), sugar alcohol (such as mannitol, sorbierite), 2-12 carbon atom
Amino acid (such as glycine, alanine, glutamic acid) and any one of inorganic salts (such as sodium phosphate, alumina silicate) or number
Kind mixture.
The skin sense modifying agent is selected from polymethylsilsesquioxane, tapioca, two C12-13 alcohol malates, two Pork and beans
Cool alcohol tartrate, PPG-15 tristearin alcohol ether, polyamide fibre -12, wineberry seed oil etc. have any in the substance for improving skin sense
Kind or several mixtures.
The antioxidant is selected from vitamin C, vitamin E, anthocyanidin, resveratrol, glutathione, superoxides discrimination
Change enzyme, saccharomycete/rice fermentation Product filtrate, plant extracts, Beauveria sp extract, kahikatea dew fungus extract, fruits and vegetables to extract
Object, polyhydric phenols of plant origin etc. have any one of anti-oxidation efficacy substance or several mixtures.
The corrigent and essence be selected from mint flavored, chocolate flavoured, fruits and vegetables taste, flowers and plants fragrance, plant flavour, vanilla flavored,
The mixture of essence or the one of the above such as caf, tea flavour, corn taste, lemon, milk flavor or several fragrance.
It is described to be selected from any one of lecithin, tween, sapn or several mixed across mucous membrane or skin penetration enhancer
Close object.
The PH regulator is selected from citric acid, sorbic acid, tartaric acid, lactic acid, malic acid, sodium bicarbonate, sodium carbonate, phosphorus
Any one of sour disodium hydrogen, calcium phosphate, potassium phosphate, tricresyl phosphate magnesium etc. or several mixtures.
The pre-dry plant tissue, processing mode can be natural seasoning, heat drying method, low temperature drying
One of method, hypobaric drying method, weight seasoning, desiccant investment, liquor seasoning, vacuum freeze-drying method are a variety of
Combination.
The invention further relates to the preparation method of the lyophilized excipient, are as follows:
1) sludge ice mixture is prepared:
A is completely or partially mixed by plant tissue binder and/or other compositions, with solvent, is congealed, is obtained sludge ice
Mixture A;
Wherein, the content of the plant tissue is 0~100 parts by weight, the content of binder and/or other auxiliary materials is 0~
100 parts by weight, the content of the solvent is 0~100 parts by weight, and the content of plant tissue and auxiliary material is not 0 simultaneously;
B technique A) it prepares after sludge ice mixture A if any residual components, can be to residual components iterative process 1) step or straight
It connects and is added in sludge ice mixture A, be for mixture B until no residual components;
2) 1) all sludge ice mixtures obtained are used into certain mould shape, the mixture B after being formed, demoulding;
3) the mixture B after sizing is freeze-dried, obtains lyophilized excipient.
The pre-dry plant tissue can carry out softening processing before a) step of method 1 and method 2.
The softening processing mode can impregnate for water logging bubble or formulation liquid, and formulation liquid is preferably not volatile
One of polyalcohol lysate, finish, the lotion comprising oil or polyalcohol, tissue cultures fixer or multiple combinations.
The product that formula and/or preparation method are prepared involved in aforesaid way, is arbitrary shape.
It can be figure of tablet, capsule shape, soft capsule shape, spherical shape, elliposoidal or various personages, animal, plant
Object, food, pattern identification or cartoon character.
When in use, it can be dissolved in using in water either formula solution, further obtain a kind of comprising plant group
The formula solution system knitted.
The formula solution can further be added thickening ingredient, dissolved plant tissue is made to be suspended in formula solution
In, to obtain more beautiful visual effect.The thickening ingredient, can selected from artificial or natural polymers,
Inorganic matter gelling agent, glue class, cellulose ethers, modified starch series, hyalomitome acids, chitosan and its different molecular weight product,
Sodium alginate, PVA, polyethylene glycol, agar, polyaminoacid, glycan or their combination;It is preferred that high molecular polymer, inorganic matter
Gelling agent, glue class, hyalomitome acids, chitosan and its different molecular weight product, sodium alginate, PVA, agar;Most preferably high score
Sub- polymer, inorganic matter gelling agent, glue class, hyalomitome acids.
Specific embodiment
The present invention is further illustrated by the following examples, but the present invention is not restricted to this.
Embodiment 1
Take the whole flower of new fresh jasmine.
Water, 0.3% melon bean gum, 5% glycerol congeal, and obtain sludge ice mixture;
Sludge ice mixture is added and carries out shaping after ball-type shaper is added in the whole flower of Jasmine according to 1 piece/;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external-use skin care essence comprising Jasmine after several are dissolved in water.
Embodiment 2
Fresh jasmine petal is taken to be freeze-dried in advance.
Water, 0.3% melon bean gum, 5% glycerol congeal, and obtain sludge ice mixture;
50% mannitol will be added in sludge ice mixture, stirs evenly;
According to 3-5 valve/grain, after ball-type shaper is added in jasmine petal, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external-use skin care essence comprising jasmine petal after several are dissolved in water.
Embodiment 3
Pre-dry jasmine petal is taken, is dipped to and is eased back using pure water.
Water, 0.3% melon bean gum, 5% glycerol congeal, and obtain sludge ice mixture;
30% modified tapioca starch will be added in sludge ice mixture, stirs evenly;
According to 3-5 valve/grain, after peach cardioid shaper is added in jasmine petal, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external application comprising jasmine petal after several are dissolved in the formula solution comprising 2.5% aluminum magnesium silicate and protecting
Skin essence.
Embodiment 4
Pre-dry jasmine petal is taken, is dipped to and is eased back using 7% glycerine water solution.
Water, 1% melon bean gum, 10% propylene glycol are congealed, and sludge ice mixture is obtained;
30% silicon powder will be added in sludge ice mixture, stirs evenly;
According to 3-5 valve/grain, after spheroid shape shaper is added in jasmine petal, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external application comprising jasmine petal after several are dissolved in the formula solution comprising 1.5% Li-montmorillonite
Facial treatment essence.
Embodiment 5
Fresh roseleaf is taken, is dried using heat drying method, and impregnates softening using grease.
Water, 0.5% Propiram, 1% melon bean gum, 10% propylene glycol are congealed, and sludge ice mixture is obtained;
50% ascorbic acid dry powder will be added in sludge ice mixture, stirs evenly;
According to 3-5 valve/grain, after ball-type shaper is added in roseleaf, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external application comprising roseleaf after several are dissolved in the formula solution comprising 1% Li-montmorillonite and protecting
Skin essence.
Embodiment 6
The whole flower of fresh sweet osmanthus is taken, natural seasoning is dry.
Using 10% glycerine water solution, softening is carried out.
Water, 0.5% Propiram, 0.5% Sodium Hyaluronate, 2% glycerol congeal, and obtain sludge ice mixture;
15% mannitol will be added in sludge ice mixture and 5% ascorbic acid dry powder stirs evenly;
According to 3 pieces/, after ball-type shaper is added in sweet osmanthus, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the external-use skin care essence comprising sweet osmanthus after several are dissolved in the formula solution comprising 1.5% aluminum magnesium silicate
China.
Embodiment 7
Fresh forget-me-not petal is taken, boulton process is dry.
Using 10% tissue cultures sizing liquor, softening is carried out.
Water, 0.5% Propiram, 0.5% Sodium Hyaluronate, 3% butanediol congeal, and obtain sludge ice mixture;
15% mannitol will be added in sludge ice mixture and 15% silicon powder dry powder stirs evenly;
According to 3-5 valve/grain, after ball-type shaper is added in forget-me-not petal, sludge ice mixture is added and carries out shaping;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, several are dissolved in water, the external-use skin care essence comprising forget-me-not petal is formed.
Embodiment 8
Take pre-dry grain.
Water, 1% melon bean gum, 5% lactalbumin congeal, and obtain sludge ice mixture;
According to 5-10/, grain is stirred evenly together with sludge ice mixture, the sizing of ball-type shaper is added;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, forming the lactalbumin drink comprising grain after several pieces are dissolved in water.
Embodiment 9
Take pre-dry Roots of Panax Notoginseng must, using purifying bubble to easing back.
Water, 0.5% Propiram, 1% melon bean gum congeal, obtain sludge ice mixture;
Roots of Panax Notoginseng must be stirred evenly together with sludge ice mixture, the sizing of ball-type shaper is added;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, the directly oral dendrobium candidum pill comprising Roots of Panax Notoginseng palpus.
Embodiment 10
Cowberry fresh fruit is taken, is freeze-dried.
Water, 0.5% Propiram, 1% melon bean gum congeal, obtain sludge ice mixture;
50% ascorbic acid dry powder will be added in sludge ice mixture, stirs evenly;
Cowberry fresh fruit is stirred evenly together with sludge ice mixture, the sizing of ball-type shaper is added;
Demoulding, is freeze-dried, obtains lyophilized excipient.
In use, 1 soluble in water, the cowberry beverage comprising cowberry fruit is formed.
It is according to the present invention at be grouped as, form and preparation method are not limited to form cited in embodiment, real
Applying example is only presently preferred embodiments of the present invention, cannot limit protection scope with this.It is all with scope of the presently claimed invention
The simple or equivalent variation and modification, comes under protection scope of the present invention.
Claims (11)
1. a kind of lyophilized excipient containing plant tissue, which is characterized in that the formula of the lyophilized excipient includes bonding
Agent and plant tissue;The plant tissue can be fresh or pre-dry, whole strain of the position selected from plant, or
It is one of flower, stem, leaf, thallus, root, fruit, seed or multiple combinations.
2. lyophilized excipient according to claim 1, which is characterized in that the binder of the lyophilized excipient,
Include low temperature bonding agent and freeze-drying binder;The two weight ratio is (1:100)~(100:1), and weight accounts for the ratio between tablet volume
For 0.1mg/cm3-5000mg/cm3;The low temperature bonding agent is alcohol, grease, surfactant, the high molecular polymerization of C1-C16
One of object or multiple combinations;The freeze-drying binder is artificial or natural polymers, inorganic matter gelling agent, fiber
Plain ethers, modified starch series, hyalomitome acids, albumin, dextran, chitosan and its different molecular weight product, alginic acid
Sodium, PVP, PVA, polyethylene glycol, agar, polyaminoacid, glycan or their combination.
3. lyophilized excipient according to claim 1, which is characterized in that the lyophilized excipient can also be into one
Step addition active matter, skeleton supporting agent, skin sense modifying agent, antioxidant, corrigent, essence, across mucous membrane, skin penetration enhancer
One or more of with pH adjusting agent.
4. lyophilized excipient according to claim 3, which is characterized in that the active matter, it is independent to be selected from as chemistry
Drug, Chinese medicine, natural extract, bioactive ingredients, skin nursing beneficiating ingredient, disinfectant, oral diet supplementation
One or more of with beautifying drug.
5. lyophilized excipient according to claim 1, which is characterized in that the pre-dry plant tissue, place
Reason mode can be natural seasoning, heat drying method, cold drying, hypobaric drying method, weight seasoning, desiccant embedding
One of method, liquor seasoning, vacuum freeze-drying method or multiple combinations.
6. lyophilized excipient according to claim 1, preparation method are as follows:
1) sludge ice mixture is prepared:
A is completely or partially mixed by plant tissue binder and/or other compositions, with solvent, is congealed, and sludge ice mixing is obtained
Object A;
Wherein, the content of the plant tissue is 0~100 parts by weight, and the content of binder and/or other auxiliary materials is 0~100 weight
Part is measured, the content of the solvent is 0~100 parts by weight, and the content of plant tissue and auxiliary material is not 0 simultaneously;
B technique A) prepare after sludge ice mixture A if any residual components, can be to residual components iterative process 1) step or directly plus
It is for mixture B until no residual components into sludge ice mixture A;
2) 1) all sludge ice mixtures obtained are used into certain mould shape, the mixture B after being formed, demoulding;
3) the mixture B after sizing is freeze-dried, obtains lyophilized excipient.
7. according to claim 1 with lyophilized excipient described in 5, which is characterized in that the pre-dry plant tissue, can
To carry out softening processing before a) step of method 1 and method 2.
8. the product being prepared by any one of claim 1-7 formula and/or preparation method.
9. lyophilized excipient described in -8 according to claim 1, which is characterized in that it is arbitrary shape.
10. product according to claim 9, which is characterized in that its for figure of tablet, capsule shape, soft capsule shape,
Spherical, elliposoidal or various personages, animal, plant, food, pattern identification or cartoon character.
11. freeze-drying excipient formulation products described in -10 according to claim 1, which is characterized in that when in use, can be molten by its
It is used in water either formula solution, further obtains a kind of formula solution system comprising plant tissue.
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Citations (2)
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CN102462665A (en) * | 2010-11-18 | 2012-05-23 | 董玲 | Preparation method for lyophilized excipient |
CN106619539A (en) * | 2015-11-02 | 2017-05-10 | 董玲 | Method for preparing freeze-dried excipient preparation in any shape and product of method |
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2017
- 2017-06-25 CN CN201710490042.1A patent/CN109106737A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102462665A (en) * | 2010-11-18 | 2012-05-23 | 董玲 | Preparation method for lyophilized excipient |
CN106619539A (en) * | 2015-11-02 | 2017-05-10 | 董玲 | Method for preparing freeze-dried excipient preparation in any shape and product of method |
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