CN109091698A - A kind of adhesive bandage and preparation method thereof containing nano silver particles - Google Patents
A kind of adhesive bandage and preparation method thereof containing nano silver particles Download PDFInfo
- Publication number
- CN109091698A CN109091698A CN201811194273.9A CN201811194273A CN109091698A CN 109091698 A CN109091698 A CN 109091698A CN 201811194273 A CN201811194273 A CN 201811194273A CN 109091698 A CN109091698 A CN 109091698A
- Authority
- CN
- China
- Prior art keywords
- silver nitrate
- electrospinning
- layer
- minutes
- adhesive bandage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention provides a kind of adhesive bandages containing nano silver particles, the adhesive bandage successively includes adhesive tape layer, sterilizing layer and hemostatic yarn layer of cloth from outside to inside, the hemostatic yarn layer of cloth and the sterilizing layer are set to the middle part of the adhesive bandage, the area of the sterilizing layer is greater than the area of the hemostatic yarn layer of cloth, and the sterilizing layer is the Static Spinning fabric containing nano silver particles.The adhesive bandage has antibacterial functions, and the secondary infection of bacterium can be caused to avoid wound and the skin whitening of wound circumference, softening.
Description
Technical field
The present invention relates to field of medicaments, especially a kind of adhesive bandage and preparation method thereof containing nano silver particles.
Background technique
Adhesive bandage is most common a kind of surgical medicine in people's life.Adhesive bandage, also known as " hemostasis plaster ", have only
Blood, protective effect.It is by an elongated adhesive plaster, and the sliver that centre is accompanied by the dipped drug of a fritter is constituted.Adhesive bandage is used for
The wound emergence therapeutic of fritter protects the surface of a wound to play the role of temporary hemostasis.But common adhesive bandage in use,
It easily causes that the skin whitening of wound and wound circumference, softening leads to the secondary infection of bacterium, leads to wound deterioration.
Nano silver, which refers to, is fabricated into nanoscale metallic silver simple substance for particle radius；Silver nanoparticles radius is generally received 25
Rice or so.Nano silver has special electricity, optics, catalytic property, can be in catalyst, battery electrode new material, conduction material
Material and low temperature Heat Conduction Material etc. generally use.Since in recent years, nano silver preparation method obtains fast development, different according to mechanism
Sample, nano-Ag particles preparation method can divide into chemical method and physics method.Physics method generally includes sputtering plating, vacuum
Vapor deposition and laser ablation method etc., way mechanism is more simple in contrast, but, manufacturing cost relatively high to instrument and equipment condition
It is more expensive.
The fiber diameter range that electrostatic spinning process technology is formed passes through fiber filament between several nanometers to several microns
The polymer material of formation possesses three-dimensional space shape, it not only possesses, and nanoparticle size is smaller, specific surface area is higher
Etc. advantages, but also possess it is mechanically stable it is outstanding, fiber membrane aperture is smaller, hole ratio is higher, fiber continuity is good etc.
Feature is owned by very big potential value in all trades and professions.
Static Spinning Ag/ high polymer nano fiber, it has not only gathered the outstanding of noble silver, high polymer and nano material
Property, and material is given many special effects, in the fields such as antibacterial, antistatic, electromagnetic shielding, ultraviolet radiation preventing
There is wide application prospect.But in actual preparation process, in the electrospinning silk solution containing nano silver particles, nano silver
Ion can unite, during electrospinning, be easy to happen syringe needle united silver ion blocking the case where, production efficiency
It is low, while nano-silver ionic cannot be evenly distributed on fiber, be not suitable for industrialized production.
Summary of the invention
For this reason, it may be necessary to provide a kind of adhesive bandage containing nano silver particles, which has antibacterial action, can be to avoid
Wound and the skin whitening of wound circumference, softening leads to the secondary infection of bacterium.It inventor provides one kind and contains nano silver
The adhesive bandage of particle, the adhesive bandage successively include adhesive tape layer, sterilizing layer and hemostatic yarn layer of cloth, the hemostatic gauze from outside to inside
Layer and the sterilizing layer are set to the middle part of the adhesive bandage, and the area of the sterilizing layer is greater than the face of the hemostatic yarn layer of cloth
Product, the sterilizing layer are the Static Spinning fabric containing nano silver particles.
Further, the Static Spinning fabric preparation the following steps are included:
Preparation electrospinning liquid: polyvinyl butyral is added into ethyl alcohol, silver nitrate is added after dissolution, silver nitrate is molten
Electrospinning liquid is obtained after solution；The concentration of silver nitrate is 0.5-2wt% in the electrospinning liquid, is gathered in the electrospinning liquid
The concentration of vinyl butyral is 5-10wt%；
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；The environment temperature of electrospinning
Degree control is at 22-28 DEG C, relative humidity 40%-60%；
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.
Silver nitrate is dissolved or dispersed in spinning liquid, can be uniform in a manner of most dispersing after electrostatic spinning process
It is distributed in electrostatic spinning nano fiber and its fabric.Silver nitrate can resolve into the oxidation of nitrogen under ultraviolet irradiation or heating condition
Object, oxygen and nano silver particles.
Further, purple when silver nitrate textile fabric is irradiated with ultraviolet light in the step of decomposition silver nitrate
The power of external radiation is 0.7-1.2W/ ㎡, and radiation temperature is 55-65 DEG C, and the time of ultraviolet radioactive is 60-100 minutes.
Further, the concentration of silver nitrate is 1.0-2.0wt% in the electrospinning liquid.
Further, the hemostatic yarn layer of cloth of the adhesive bandage processing preparation the following steps are included:
It crushes: the Chinese herbal medicine with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 30-50 minutes, boils 10-20 in heating
Gauze is added in minute backward water, continues to boil the heating of stopping in 20-30 minutes, gauze continues to impregnate 120-180 minutes in water
After take out,
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze.
Further, the Chinese herbal medicine particle, water, gauze mass ratio be 50-60:300-500:30-40.
Further, the Chinese herbal medicine include bletilla, more than blood, hairyvein agrimony, Radix Notoginseng, cacumen biotae, folium artemisiae argyi, garden burnet, sophora flower,
Field thistle, rhizoma imperatae, Japanses beauty-berry grass and madder or combinations thereof.
Inventor additionally provides the preparation method of the above-mentioned adhesive bandage containing nano silver particles, the preparation method includes
Following steps:
The preparation of sterilizing layer:
Preparation electrospinning liquid: polyvinyl butyral is added into ethyl alcohol, silver nitrate is added after dissolution, silver nitrate is molten
Electrospinning liquid is obtained after solution；The concentration of silver nitrate is 0.5-2wt% in the electrospinning liquid, is gathered in the electrospinning liquid
The concentration of vinyl butyral is 5-10wt%；
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；The environment temperature of electrospinning
Degree control is at 22-28 DEG C, relative humidity 40%-60%；
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles is as sterilizing layer.
The preparation of hemostatic yarn layer of cloth:
It crushes: the Chinese herbal medicine with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 30-50 minutes, boils 10-20 in heating
Gauze is added in minute backward water, continues to boil the heating of stopping in 20-30 minutes, gauze continues to impregnate 120-180 minutes in water
After take out,
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze；
Heat pressure adhesive: hot pressing adhesion will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting, temperature is
120-160 DEG C, obtain a kind of adhesive bandage containing nano silver particles.It is different from the prior art, the wound that above-mentioned technical proposal provides
It can paste, containing nano silver particles, there are antibacterial functions, can cause to avoid wound and the skin whitening of wound circumference, softening thin
The secondary infection of bacterium.
Detailed description of the invention
Fig. 1 is that the SEM of the Static Spinning fabric (silver nitrate concentration 0.5wt%) containing nano silver particles schemes；
Fig. 2 is that the SEM of the Static Spinning fabric (silver nitrate concentration 1.0wt%) containing nano silver particles schemes；
Fig. 3 is that the SEM of the Static Spinning fabric (silver nitrate concentration 2.0wt%) containing nano silver particles schemes；
Fig. 4 is the XRD diagram of the Static Spinning fabric containing nano silver particles；
Fig. 5 is the XRD diagram of silver nitrate textile fabric.
Specific embodiment
Technology contents, construction feature, the objects and the effects for detailed description technical solution, below in conjunction with specific reality
It applies example and attached drawing is cooperated to be explained in detail.
A kind of adhesive bandage containing nano silver particles of embodiment 1
1, the preparation of sterilizing layer
Prepare electrospinning liquid: with silver nitrate after ethyl alcohol polyethylene dissolving butyral, is added, stirring and dissolving is prepared quiet
Electrospinning knits liquid；Wherein silver nitrate concentration is 0.5wt%, and the concentration of PVB is 7.375wt%, magnetic agitation 15-18h, makes it completely
Dissolution reaches transparence,
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；Electro-spinning process environment temperature
22-28 DEG C of control, relative humidity 40%-60%.Electrospinning processes parameter is that collection distance (12 ± 1) cm, voltage are (22 ± 2)
KV, flow velocity 1.5mL/h, single needle, 10 hours of spinning.
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.Using the ultraviolet accelerated weathering machine of QUV, 60 DEG C of radiation temperature, power 0.89W/ ㎡, irradiation time
It is 60 minutes, obtains the Static Spinning fabric containing nano silver particles.
In preparation, Silver nanoparticles are prepared by reducing metal precursor silver nitrate using preceding, are forming nanofiber
It is restored after film, can preferably avoid the problem of uniting of nano silver particles, silver particles are more uniform to be distributed in tunica fibrosa
Middle formation possesses the novel high molecular polymer material of specificity structure and function.
2, the preparation of hemostatic yarn layer of cloth:
It crushes: hairyvein agrimony, Radix Notoginseng, field thistle with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size, celestial being
Crane grass, Radix Notoginseng, field thistle mass ratio be 1:2:2.
Heating: the Chinese herbal medicine particle is added to the water, and immersion is heated after forty minutes, after heating boils 15 minutes
Gauze is added in Xiang Shuizhong, continues to boil the heating of stoppings in 25 minutes, and gauze takes out after continuing immersion in water 160 minutes, it is described in
Herbal granules, water, gauze mass ratio be 60:300:30.
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze.
3, hot pressing adhesion, temperature 120-160 will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting
DEG C, obtain a kind of adhesive bandage containing nano silver particles.The hemostatic yarn layer of cloth and the sterilizing layer are set to the adhesive bandage
Middle part, the size of the sterilizing layer is 1 × 2cm, and the size of the hemostatic yarn layer of cloth is 1.5 × 3cm, the ruler of the adhesive tape layer
Very little is 3 × 5cm.
In adhesion process, the temperature and pressure will not tamper protection isolation layer and Chinese herbal medicine finish fabric layer performance, it is quiet
Electrospun nano-fibers film and the bonding of Chinese herbal medicine finish fabric layer can be used compound adhesive and carry out increase degree of adhesion.
Static Spinning fabric and the silver nitrate weaving that identical process produces prepared by embodiment 1 containing nano silver particles is fine
It ties up (not carrying out the decomposition of silver nitrate), with XRD characterization is carried out, wherein Fig. 4 is the XRD of the Static Spinning fabric containing nano silver particles
Figure；Fig. 5 is the XRD diagram of silver nitrate textile fabric.
From Fig. 4, Fig. 5, it can be seen that diffraction maximum does not occur in Fig. 5, illustrates that silver nitrate textile fabric does not occur nano silver.
And there is diffraction maximum in the Static Spinning fabric that Fig. 4 contains nano silver particles, the diffraction maximum containing nano silver in diffraction maximum illustrates purple
Make to restore nano silver in tunica fibrosa within UV radiation 60 minutes.
Fig. 1 is that the SEM of the Static Spinning fabric (silver nitrate concentration 0.5wt%) containing nano silver particles schemes.
A kind of adhesive bandage containing nano silver particles of embodiment 2
1, the preparation of sterilizing layer
Prepare electrospinning liquid: with silver nitrate after ethyl alcohol polyethylene dissolving butyral, is added, stirring and dissolving is prepared quiet
Electrospinning knits liquid；Wherein silver nitrate concentration is 1wt%, and the concentration of PVB is 7.375wt%, magnetic agitation 15-18h, keeps it completely molten
Solution reaches transparence,
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；Electro-spinning process environment temperature
22-28 DEG C of control, relative humidity 40%-60%.Electrospinning processes parameter is that collection distance (12 ± 1) cm, voltage are (22 ± 2)
KV, flow velocity 1.5mL/h, single needle, 10 hours of spinning.
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.Using the ultraviolet accelerated weathering machine of QUV, 60 DEG C of radiation temperature, power 0.89W/ ㎡, irradiation time
It is 60 minutes, obtains the Static Spinning fabric containing nano silver particles.
2, the preparation of hemostatic yarn layer of cloth:
It crushes: hairyvein agrimony, Radix Notoginseng, cacumen biotae with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Hairyvein agrimony, Radix Notoginseng, cacumen biotae mass ratio be 1:2:3.
Heating: the Chinese herbal medicine particle is added to the water, and immersion is heated after forty minutes, after heating boils 15 minutes
Gauze is added in Xiang Shuizhong, continues to boil the heating of stoppings in 25 minutes, and gauze takes out after continuing immersion in water 150 minutes, it is described in
Herbal granules, water, gauze mass ratio be 50:300:40.
Drying: hemostatic yarn layer of cloth is obtained after 121-125 DEG C of gauze is dried 25 minutes.
3, hot pressing adhesion, temperature 120-160 will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting
DEG C, obtain a kind of adhesive bandage containing nano silver particles.The hemostatic yarn layer of cloth and the sterilizing layer are set to the adhesive bandage
Middle part, the size of the sterilizing layer is 2 × 3cm, and the size of the hemostatic yarn layer of cloth is 1 × 2cm, the size of the adhesive tape layer
For 3 × 5cm.
Fig. 2 is that the SEM of the Static Spinning fabric (silver nitrate concentration 1.0wt%) containing nano silver particles schemes；
A kind of adhesive bandage containing nano silver particles of embodiment 3
1, the preparation of sterilizing layer
Prepare electrospinning liquid: with silver nitrate after ethyl alcohol polyethylene dissolving butyral, is added, stirring and dissolving is prepared quiet
Electrospinning knits liquid；Wherein silver nitrate concentration is 2wt%, and the concentration of PVB is 7.375wt%, magnetic agitation 15-18h, keeps it completely molten
Solution reaches transparence,
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；Electro-spinning process environment temperature
22-28 DEG C of control, relative humidity 40%-60%.Electrospinning processes parameter is that collection distance (12 ± 1) cm, voltage are (22 ± 2)
KV, flow velocity 1.5mL/h, single needle, 10 hours of spinning.
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.Using the ultraviolet accelerated weathering machine of QUV, 55 DEG C of radiation temperature, power 1.2W/ ㎡, irradiation time
It is 60 minutes, obtains the Static Spinning fabric containing nano silver particles.
2, the preparation of hemostatic yarn layer of cloth:
It crushes: hairyvein agrimony, Radix Notoginseng, cacumen biotae with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Hairyvein agrimony, Radix Notoginseng, cacumen biotae mass ratio be 1:2:3.
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 35 minutes, after heating boils 15 minutes
Gauze is added in Xiang Shuizhong, continues to boil the heating of stoppings in 25 minutes, and gauze takes out after continuing immersion in water 150 minutes, it is described in
Herbal granules, water, gauze mass ratio be 50:300:40.
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze.
3, hot pressing adhesion, temperature 120-160 will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting
DEG C, obtain a kind of adhesive bandage containing nano silver particles.The hemostatic yarn layer of cloth and the sterilizing layer are set to the adhesive bandage
Middle part, the size of the sterilizing layer is 2 × 3cm, and the size of the hemostatic yarn layer of cloth is 1 × 2cm, the size of the adhesive tape layer
For 3 × 5cm.
Fig. 3 is that the SEM of the Static Spinning fabric (silver nitrate concentration 2.0wt%) containing nano silver particles schemes.
A kind of adhesive bandage containing nano silver particles of embodiment 3
1, the preparation of sterilizing layer
Prepare electrospinning liquid: with silver nitrate after ethyl alcohol polyethylene dissolving butyral, is added, stirring and dissolving is prepared quiet
Electrospinning knits liquid；Wherein silver nitrate concentration is 1wt%, and the concentration of PVB is 5wt%, and magnetic agitation 15-18h makes it completely dissolved and reaches
To transparence,
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；Electro-spinning process environment temperature
22-28 DEG C of control, relative humidity 40%-60%.Electrospinning processes parameter is that collection distance (12 ± 1) cm, voltage are (22 ± 2)
KV, flow velocity 1.5mL/h, single needle, 10 hours of spinning.
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.Using the ultraviolet accelerated weathering machine of QUV, 55 DEG C of radiation temperature, power 1.2W/ ㎡, irradiation time
It is 60 minutes, obtains the Static Spinning fabric containing nano silver particles.
2, the preparation of hemostatic yarn layer of cloth:
It crushes: hairyvein agrimony, Radix Notoginseng, cacumen biotae with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Hairyvein agrimony, Radix Notoginseng, cacumen biotae mass ratio be 1:2:3.
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 30 minutes, boils 10-20 points in heating
Gauze is added after clock into water, continues to boil the heating of stopping in 20 minutes, gauze continues to take out after impregnating 120 minutes in water, institute
State Chinese herbal medicine particle, water, gauze mass ratio be 55:400:35.
Drying: 121-125 DEG C of gauze drying is obtained into hemostatic yarn layer of cloth after twenty minutes.
3, hot pressing adhesion, temperature 120-160 will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting
DEG C, obtain a kind of adhesive bandage containing nano silver particles.The hemostatic yarn layer of cloth and the sterilizing layer are set to the adhesive bandage
Middle part, the size of the sterilizing layer is 2 × 3cm, and the size of the hemostatic yarn layer of cloth is 1 × 2cm, the size of the adhesive tape layer
For 3 × 5cm.
A kind of adhesive bandage containing nano silver particles of embodiment 3
1, the preparation of sterilizing layer
Prepare electrospinning liquid: with silver nitrate after ethyl alcohol polyethylene dissolving butyral, is added, stirring and dissolving is prepared quiet
Electrospinning knits liquid；Wherein silver nitrate concentration is 1wt%, and the concentration of PVB is 10wt%, and magnetic agitation 15-18h makes it completely dissolved
Reach transparence,
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；Electro-spinning process environment temperature
22-28 DEG C of control, relative humidity 40%-60%.Electrospinning processes parameter is that collection distance (12 ± 1) cm, voltage are (22 ± 2)
KV, flow velocity 1.5mL/h, single needle, 10 hours of spinning.
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing receiving
The Static Spinning fabric of rice silver particles.Using the ultraviolet accelerated weathering machine of QUV, 55 DEG C of radiation temperature, power 1.0W/ ㎡, irradiation time
It is 300 minutes, obtains the Static Spinning fabric containing nano silver particles.
2, the preparation of hemostatic yarn layer of cloth:
It crushes: garden burnet, sophora flower, madder with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size, garden burnet,
Sophora flower, madder mass ratio be 2:2:3.
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 50 minutes, boils 10-20 points in heating
Gauze is added after clock into water, continues to boil the heating of stopping in 30 minutes, gauze continues to take out after impregnating 180 minutes in water, institute
State Chinese herbal medicine particle, water, gauze mass ratio be 55:400:35.
Drying: hemostatic yarn layer of cloth is obtained after 121-125 DEG C of gauze is dried 30 minutes.
3, hot pressing adhesion will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting, temperature is 160 DEG C, is obtained
To a kind of adhesive bandage containing nano silver particles.The hemostatic yarn layer of cloth and the sterilizing layer are set in the adhesive bandage
Portion, the size of the sterilizing layer are 2 × 3cm, and the size of the hemostatic yarn layer of cloth is 1 × 2cm, and the size of the adhesive tape layer is 3
×5cm。
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or the terminal device that include a series of elements not only include those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or end
The intrinsic element of end equipment.In the absence of more restrictions, being limited by sentence " including ... " or " including ... "
Element, it is not excluded that there is also other elements in process, method, article or the terminal device for including the element.This
Outside, herein, " being greater than ", " being less than ", " being more than " etc. are interpreted as not including this number；" more than ", " following ", " within " etc. understand
Being includes this number.
It should be noted that being not intended to limit although the various embodiments described above have been described herein
Scope of patent protection of the invention.Therefore, it based on innovative idea of the invention, change that embodiment described herein is carried out and is repaired
Change, or using equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content, it directly or indirectly will be with
Upper technical solution is used in other related technical areas, is included within scope of patent protection of the invention.
Claims (8)
1. a kind of adhesive bandage containing nano silver particles, which is characterized in that the adhesive bandage from outside to inside successively include adhesive tape layer,
Sterilizing layer and hemostatic yarn layer of cloth, the hemostatic yarn layer of cloth and the sterilizing layer are set to the middle part of the adhesive bandage, the disinfection
The area of layer is greater than the area of the hemostatic yarn layer of cloth, and the sterilizing layer is the Static Spinning fabric containing nano silver particles.
2. adhesive bandage according to claim 1, which is characterized in that the preparation of the Static Spinning fabric the following steps are included:
Preparation electrospinning liquid: polyvinyl butyral being added into ethyl alcohol, silver nitrate is added after dissolution, after silver nitrate dissolution
Obtain electrospinning liquid；The concentration of silver nitrate is 0.5-2wt%, polyethylene in the electrospinning liquid in the electrospinning liquid
The concentration of butyral is 5-10wt%；
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；The environment temperature control of electrospinning
System is at 22-28 DEG C, relative humidity 40%-60%；
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing nano silver
The Static Spinning fabric of particle.
3. adhesive bandage according to claim 1, which is characterized in that in the step of the decomposition silver nitrate, when silver nitrate is spun
When textured fiber is irradiated with ultraviolet light, the power of ultraviolet radioactive is 0.7-1.2W/ ㎡, and radiation temperature is 55-65 DEG C, ultraviolet spoke
The time penetrated is 60-100 minutes.
4. adhesive bandage according to claim 1, which is characterized in that the concentration of silver nitrate is 1.0- in the electrospinning liquid
2.0wt%.
5. adhesive bandage according to claim 1, which is characterized in that the processing of the hemostatic yarn layer of cloth of the adhesive bandage prepares packet
Include following steps:
It crushes: the Chinese herbal medicine with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 30-50 minutes, is boiled 10-20 minutes in heating
Gauze is added in backward water, continues to boil the heating of stopping in 20-30 minutes, gauze continues to take after impregnating 120-180 minutes in water
Out,
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze.
6. adhesive bandage according to claim 5, which is characterized in that the Chinese herbal medicine particle, water, gauze mass ratio be
50-60:300-500:30-40。
7. the Chinese herbal medicine according to claim 5 with hemostatic function, which is characterized in that the Chinese herbal medicine includes white
And blood is remaining, hairyvein agrimony, Radix Notoginseng, cacumen biotae, folium artemisiae argyi, garden burnet, sophora flower, field thistle, rhizoma imperatae, Japanses beauty-berry grass, madder or combinations thereof.
8. a kind of preparation method as described in claim 1 containing nano silver particles adhesive bandage, which is characterized in that the adhesive bandage
Preparation the following steps are included:
The preparation of sterilizing layer:
Preparation electrospinning liquid: polyvinyl butyral being added into ethyl alcohol, silver nitrate is added after dissolution, after silver nitrate dissolution
Obtain electrospinning liquid；The concentration of silver nitrate is 0.5-2wt%, polyethylene in the electrospinning liquid in the electrospinning liquid
The concentration of butyral is 5-10wt%；
Electrospinning: electrospinning liquid is subjected to electrospinning, obtains silver nitrate textile fabric；The environment temperature control of electrospinning
System is at 22-28 DEG C, relative humidity 40%-60%；
It decomposes silver nitrate: silver nitrate textile fabric is subjected to ultraviolet irradiation, the silver nitrate in fiber decomposes, and obtains containing nano silver
The Static Spinning fabric of particle is as sterilizing layer.
The preparation of hemostatic yarn layer of cloth:
It crushes: the Chinese herbal medicine with hemostatic function crushes as 10-20 μm of Chinese herbal medicine particle of partial size,
Heating: the Chinese herbal medicine particle is added to the water, and is heated after impregnating 30-50 minutes, is boiled 10-20 minutes in heating
Gauze is added in backward water, continues to boil the heating of stopping in 20-30 minutes, gauze continues to take after impregnating 120-180 minutes in water
Out,
Drying: hemostatic yarn layer of cloth will be obtained after drying 20-30 minutes of 121-125 DEG C of gauze；
Heat pressure adhesive: hot pressing adhesion, temperature 120- will be carried out from top to bottom after hemostatic yarn layer of cloth, sterilizing layer, adhesive tape layer cutting
160 DEG C, obtain a kind of adhesive bandage containing nano silver particles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811194273.9A CN109091698A (en) | 2018-10-15 | 2018-10-15 | A kind of adhesive bandage and preparation method thereof containing nano silver particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811194273.9A CN109091698A (en) | 2018-10-15 | 2018-10-15 | A kind of adhesive bandage and preparation method thereof containing nano silver particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109091698A true CN109091698A (en) | 2018-12-28 |
Family
ID=64868748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811194273.9A Pending CN109091698A (en) | 2018-10-15 | 2018-10-15 | A kind of adhesive bandage and preparation method thereof containing nano silver particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109091698A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101096424A (en) * | 2007-06-27 | 2008-01-02 | 东华大学 | Glutin nano fabric film containing nano silver and preparation and application thereof |
| CN105012996A (en) * | 2015-08-03 | 2015-11-04 | 罗静峰 | Gauze capable of quickly stopping bleeding |
| CN204971864U (en) * | 2015-08-18 | 2016-01-20 | 苏木英 | Nano -silver antibacterial woundplast |
| CN106726145A (en) * | 2016-12-29 | 2017-05-31 | 芜湖研高粘胶新材料有限公司 | A kind of sterilized adhesive bandage |
-
2018
- 2018-10-15 CN CN201811194273.9A patent/CN109091698A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101096424A (en) * | 2007-06-27 | 2008-01-02 | 东华大学 | Glutin nano fabric film containing nano silver and preparation and application thereof |
| CN105012996A (en) * | 2015-08-03 | 2015-11-04 | 罗静峰 | Gauze capable of quickly stopping bleeding |
| CN204971864U (en) * | 2015-08-18 | 2016-01-20 | 苏木英 | Nano -silver antibacterial woundplast |
| CN106726145A (en) * | 2016-12-29 | 2017-05-31 | 芜湖研高粘胶新材料有限公司 | A kind of sterilized adhesive bandage |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zille et al. | Application of nanotechnology in antimicrobial finishing of biomedical textiles | |
| Zhang et al. | In situ assembly of well-dispersed Ag nanoparticles throughout electrospun alginate nanofibers for monitoring human breath—Smart fabrics | |
| CN105839291B (en) | A kind of nanofiber antibacterial nonwoven material and preparation method | |
| Hong | Preparation and properties of electrospun poly (vinyl alcohol)/silver fiber web as wound dressings | |
| CN102584211B (en) | Method for preparing micro/nano porous ceramic fibers by low-temperature electrostatic spinning | |
| Xu et al. | Antimicrobial gelatin nanofibers containing silver nanoparticles | |
| CN103394114B (en) | A kind of preparation method of medical dressing chitosan-based superfine fiber carrier material | |
| Li et al. | Design of polymeric nanofiber gauze mask to prevent inhaling PM2. 5 particles from haze pollution | |
| CN102493126A (en) | Composite fiber material containing nanosilver and preparation method thereof | |
| CN104790064A (en) | Piezoelectric polymer/metal composite nano-filament and preparation method thereof | |
| CN106983902A (en) | A kind of novel nano composite wound bandage | |
| CN109966538A (en) | A kind of micro-current wound promotees to be cured antiseptic dressing and preparation method thereof | |
| Sampath Kumar et al. | Electrospun polyurethane and soy protein nanofibres for wound dressing applications | |
| CN109091698A (en) | A kind of adhesive bandage and preparation method thereof containing nano silver particles | |
| Lagaron et al. | Biomedical applications of electrospinning, innovations, and products | |
| CN109338484A (en) | A kind of Static Spinning fabric and its production method and purposes containing nano silver particles | |
| CN112609330B (en) | Preparation method of antibacterial adsorption fiber membrane, product and application thereof | |
| CN109402775A (en) | A kind of essential oil sustained release nano fiber and preparation method thereof | |
| CN111876906A (en) | Non-woven fabric with high filtering performance and processing technology thereof | |
| CN108914561A (en) | A kind of silver nitrate Static Spinning fabric and its production method and purposes | |
| KR100630864B1 (en) | A method for producing nano-fiber and a nano-fiber produced by the same | |
| CN109837763A (en) | A kind of preparation method of pearl powder base uvioresistant fabric | |
| KR100839088B1 (en) | Anti-bacterial bandage and its manufacturing methods | |
| CN116084042A (en) | Manufacturing method of multifunctional Chinese mugwort herb fiber material | |
| Tseng et al. | Bacteriostatic substrate by conductivity method and electric spark discharge method combined with electrospinning for silver dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181228 |
|
| RJ01 | Rejection of invention patent application after publication |