CN109077804A - A kind of Microwave Coagulation Therapy method of planning based on ct images - Google Patents

A kind of Microwave Coagulation Therapy method of planning based on ct images Download PDF

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Publication number
CN109077804A
CN109077804A CN201810944806.4A CN201810944806A CN109077804A CN 109077804 A CN109077804 A CN 109077804A CN 201810944806 A CN201810944806 A CN 201810944806A CN 109077804 A CN109077804 A CN 109077804A
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inserting needle
dimensional
path
microwave
thermal
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刘琪
姜杉
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Tianjin University
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Tianjin University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10Computer-aided planning, simulation or modelling of surgical operations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101Computer-aided simulation of surgical operations
    • A61B2034/105Modelling of the patient, e.g. for ligaments or bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/107Visualisation of planned trajectories or target regions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/108Computer aided selection or customisation of medical implants or cutting guides

Abstract

The invention discloses a kind of Microwave Coagulation Therapy method of planning based on ct images, comprising the following steps: reads patient's medical image sequences and shows, carries out three-dimensional reconstruction;According to three-dimensional visualization as a result, selecting best inserting needle number and inserting needle path, which can avoid vital tissue organ and there are safe distances, while the path is the shortest path on skin between entry point and target area;According to the geometry of preset inserting needle path and tumour, using automatic Three Dimensional Thermal injectivity optimizing algorithm, it is Converse solved go out optimal input parameter;The range for showing three-dimensional tissue's damage field and temperature field, to treatment plan outcome evaluation.This method can assist doctor to formulate the preoperative plan that reasonable microwave ablation is performed the operation, simulate the clinical implementation effect of the operation plan of doctor's design in the preoperative by computer simulation method, reliable surgical guidance is provided for doctor, to reduce the difficulty of implementation of operation, so that operation is safer, the damage extra to patient is reduced.

Description

A kind of Microwave Coagulation Therapy method of planning based on ct images
Technical field
The present invention relates to microwave ablation techniques fields, belong to the front subject that computer intersects with medicine intervention field, especially It is related to a kind of Microwave Coagulation Therapy method of planning based on ct images.
Background technique
Microwave ablation operation is current treatment one of liver cancer or the main means of lung cancer, is that a kind of effective intervention tumour is controlled Treatment method.Patient after local anaesthesia patient, can pass through needle-like antenna for radiating microwave without operating on over the course for the treatment of for it It crosses skin penetrating and enters inside tumor, destroy tumor tissues using the local hot spots that microwave generates, and then achieve the purpose that treatment.
Compared with traditional resection operation, microwave ablation operation is with following technical advantage: first, microwave ablation can be anti- Multiple treatment, it is reproducible, and predictable ablation range size.Second, microwave ablation has very wide and does not depend on tissue The active heating area of electric conductivity, transmission of the microwave energy in living tissue be not dry by tissue and charing is limited.Therefore, it swells Enough temperature be can achieve in tumor to guarantee to create a sufficiently large ablation areas, use shorter treatment time is more thorough Inactivation tumour.Third, less " heat drop " effect by perfusion medium of microwave ablation are influenced, can preferably be inactivated by nearby bleeding The tumour of pipe.4th, the electron interference phenomenon present in RF ablation will not occur when multiple microwave energies act synergistically, The ablation range of tumour can easily be expanded by synergistic effect in a short time in this way.5th, micro-wave therapeutic is being performed the operation In have apparent coagulating effectiveness, the danger bled profusely in patient's art can be effectively reduced.Traditional microwave ablation operation refers to Under the guidance of medical image, doctor melts tumor region by adjusting microwave power and time, inputs parameter Selection is heavily dependent on the clinical experience of doctor.Little tumour can be melted using single needle, but work as the diameter of tumour When larger or in irregular shape, it is excessively high and then lead to carbonized that single needle ablation easily causes local temperature, or even can damage week Side normal tissue needs to be implanted into more ablation needles just at this time to reach therapeutic purposes.Spininess ablative surgery difficulty is big, while to doctor More stringent requirements are proposed for raw level.
The quality of ablative surgery effect depends primarily on whether zone of ablation is completely covered target area, and whether vitals are by heat Damage, whether normal surrounding tissue is by biggish damage.Preoperative planning is significant for ablative surgery, it can have A possibility that effect reduces the damage to patient body and reduces postoperative recurrence.
Summary of the invention
Purpose of the invention is to overcome the shortcomings in the prior art, provides a kind of microwave ablation based on ct images and controls Method of planning is treated, this method can assist doctor to formulate the preoperative plan of reasonable microwave ablation operation, pass through computer simulation Method simulates the clinical implementation effect of the operation plan of doctor's design in the preoperative, provides reliable surgical guidance for doctor, thus The difficulty of implementation of operation is reduced, so that operation is safer, reduces the damage extra to patient.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of Microwave Coagulation Therapy method of planning based on ct images, for assist doctor formulate surgical planning, including into Needle path diameter, depth of needle and microwave input parameter, comprising the following steps:
(1) patient's medical image sequences are read and are shown, three-dimensional reconstruction is carried out;
(2) according to three-dimensional visualization as a result, selecting best inserting needle number and inserting needle path, which can avoid important set It knits organ and there are safe distance, while the path is the shortest path on skin between entry point and target area;
(3) according to the geometry of preset inserting needle path and tumour, using automatic Three Dimensional Thermal injectivity optimizing algorithm, It is Converse solved go out optimal input parameter;
(4) range of display three-dimensional tissue damage field and temperature field, to treatment plan outcome evaluation.
3. in step (3), to obtain optimal treatment parameter setting objective function, making target area thermal dose highest, remaining group Knit smaller, the objective function that is heated are as follows:
Wherein, NkThe thermal field of the organ covered for k-th by thermal dose calculates the number of point, ωn.kFor k-th by thermit powder Measure the weight factor of n-th of target spot in the organ of covering, ωn.kSize according to the significance level of the organ covered by thermal dose Setting, the smaller distribution for indicating thermal dose of the value of F are more reasonable;
Automatic Three Dimensional Thermal injectivity optimizing algorithm flow is as follows:
A. after providing inserting needle number and inserting needle path, original state i, initial input power P are set0When with heating Between t0, annealing temperature Ti, calculate objective function FiValue;
B. current state is added and is disturbed, changed microwave power, treatment time or needle position of cusp, a new shape will be obtained State j;
C. the objective function F of state j is calculatedj, and the size of new and old two objective functions: Δ T=Fj-Fi;If Δ Input parameter and needle position of cusp are then adjusted to j state by T < 0;If Δ T > 0, parameter or needle position of cusp are inputted at this time It can be with exp (- Δ T/Ti) be adjusted;
D. annealing temperature T is calculatedi+1=α Ti, α is the coefficient for controlling annealing temperature decrease speed, if annealing temperature Ti+1Not Reach minimum temperature, then continue step b, if annealing temperature Ti+1Reach minimum temperature, judges whether there is the target not inactivated Point;If so, carrying out step b starts new round iteration;If it is not, input power P and heating time after output optimization t。
Compared with prior art, the beneficial effects brought by the technical solution of the present invention are as follows:
(1) the method for the present invention can reduce the blindness of microwave ablation operation, reduce the damage to patient body, improve hand The accuracy of art.
(2) the method for the present invention can be by the three-dimensional visualizations such as targeted site, bone, big blood vessel and vitals, Yi Shengke Intuitively to determine specific location of the tumour in 3 D anatomy structure, and reasonable ablation needle number is selected, it can be constantly Adjust inserting needle path.
(3) this method can be according to preset path and tumour geometry, and target area can be completely covered by calculating And the smallest microwave power and treatment time are damaged to normal surrounding tissue.Existing preoperative planning system is to pass through doctor mostly Input parameter is manually set, according to the relativeness for calculating the thermal damage's range and target area that get, continuously adjusts input parameter Until meeting clinical demand.The present invention can difficulty that is more time saving and reducing preoperative planning, while make it is preoperative planning more It is accurate to add.
Detailed description of the invention
Fig. 1 is the flow diagram of the method for the present invention.
Fig. 2 is ablative surgery inserting needle schematic diagram.
Fig. 3 is the automatic Three Dimensional Thermal injectivity optimizing algorithm flow chart based on simulated annealing.
Specific embodiment
The invention will be further described with reference to the accompanying drawing.
Fig. 1 is the flow diagram of the method for the present invention, including inserting needle path planning process and reverse thermal dose optimization process, The process of the therapy planning method are as follows:
Step A: patient's medical image sequences are read and are shown, three-dimensional reconstruction is carried out;
Step B: according to three-dimensional visualization as a result, selecting best inserting needle number and inserting needle path.Fig. 2 is of the present invention Ablative surgery inserting needle schematic diagram, the selection principle of best inserting needle path are that zone of ablation is made to cover tumour most possibly and to disease The injury of people is minimum.Since in puncture process, there are Soft Tissue Deformations and other random errors to exist, so point of puncture on skin The shortest distance between target is considered as best inserting needle path.Simultaneously inserting needle path need to avoid big blood vessel, rib cage and Vitals and there are certain safe distance, cannot interfere between ablation needle.Therefore, inserting needle number and inserting needle path can It is constantly adjusted according to the three-dimensional reconstruction result of system.
Step C: it according to the geometry of preset inserting needle path and tumour, is calculated using automatic Three Dimensional Thermal injectivity optimizing Method, it is Converse solved go out optimal input parameter;When doctor only needs to one initial microwave power of every ablation needle and heating Between, by automatic Three Dimensional Thermal injectivity optimizing algorithm can calculate can complete inactivation tumour simultaneously to patient body damage it is the smallest Microwave power and heating time.Optimal treatment parameter setting objective function in order to obtain, makes target area thermal dose highest, remaining group Knit smaller, the objective function that is heated are as follows:
Wherein, NkThe thermal field of the organ covered for k-th by thermal dose calculates the number of point, ωn.kFor k-th by thermit powder Measure the weight factor of n-th of target spot in the organ of covering, ωn.kSize according to the significance level of the organ covered by thermal dose Setting.The value of F is smaller, illustrates that the distribution of thermal dose is more reasonable.
Fig. 3 is Three Dimensional Thermal injectivity optimizing algorithm flow chart, the specific steps are as follows:
Step C1: after doctor rule of thumb provides inserting needle number and inserting needle path, setting original state i, initially Input power P0With heating time t0, annealing temperature Ti, calculate objective function FiValue.
Step C2: adding current state and disturb, and changes microwave power, treatment time or needle position of cusp, will obtain one A new state j.
Step C3: the objective function F of state j is calculatedj, and the size of new and old two objective functions;Δ T=Fj-Fi, If Δ T < 0, input parameter and needle position of cusp are adjusted to j state;If Δ T > 0, parameter or needle point are inputted at this time Point position can be with exp (- Δ T/Ti) probability be adjusted.
Step C4: annealing temperature T is calculatedi+1=α Ti, α is the coefficient for controlling annealing temperature decrease speed, if annealing temperature Ti+1Not up to minimum temperature then continues step C2.If annealing temperature Ti+1Reach minimum temperature, judges whether there is and do not go out Target spot living.If so, carrying out step C2 starts new round iteration;If it is not, exporting the input power P after optimization and adding Hot time t.
Step D: the range of display three-dimensional tissue thermal damage and temperature field, to treatment plan outcome evaluation.The three of display Dimension tissue thermal damage is the maximum ablation boundary that can inactivate tumour, and melting boundary by maximum can be seen that preoperative plan is imitated The quality of fruit, to treatment plan outcome evaluation.Select volume larger in specific implementation process and tumour in irregular shape, root It needs to evade bone tissue according to the location and shape where tumour, uses two ablation needles to reach ablation purpose.According to inserting needle road The selection principle of diameter is that two ablation needles select reasonable inserting needle path.According to optimization algorithm proposed above, finally acquire Optimal entry point position, input power P and time t.
The present invention is not limited to embodiments described above.Above the description of specific embodiment is intended to describe and say Bright technical solution of the present invention, the above mentioned embodiment is only schematical, is not restrictive.This is not being departed from In the case of invention objective and scope of the claimed protection, those skilled in the art may be used also under the inspiration of the present invention The specific transformation of many forms is made, within these are all belonged to the scope of protection of the present invention.

Claims (2)

1. a kind of Microwave Coagulation Therapy method of planning based on ct images, for assisting doctor to formulate surgical planning, including inserting needle Path, depth of needle and microwave input parameter, which comprises the following steps:
(1) patient's medical image sequences are read and are shown, three-dimensional reconstruction is carried out;
(2) according to three-dimensional visualization as a result, selecting best inserting needle number and inserting needle path, which can avoid vital tissue device Official and there are safe distances, while the path is the shortest path on skin between entry point and target area;
(3) according to the geometry of preset inserting needle path and tumour, using automatic Three Dimensional Thermal injectivity optimizing algorithm, inversely Solve optimal input parameter;
(4) range of display three-dimensional tissue damage field and temperature field, to treatment plan outcome evaluation.
2. a kind of Microwave Coagulation Therapy method of planning based on ct images according to claim 1, which is characterized in that step (3) in, to obtain optimal treatment parameter setting objective function, make target area thermal dose highest, remaining tissue is heated smaller, target Function are as follows:
Wherein, NkThe thermal field of the organ covered for k-th by thermal dose calculates the number of point, ωn.kIt is covered for k-th by thermal dose Organ in n-th of target spot weight factor, ωn.kSize according to the significance level of the organ covered by thermal dose set, F Value it is smaller indicate thermal dose distribution it is more reasonable;
Automatic Three Dimensional Thermal injectivity optimizing algorithm flow is as follows:
A. after providing inserting needle number and inserting needle path, original state i, initial input power P are set0With heating time t0, Annealing temperature Ti, calculate objective function FiValue;
B. current state is added and is disturbed, changed microwave power, treatment time or needle position of cusp, a new state j will be obtained;
C. the objective function F of state j is calculatedj, and the size of new and old two objective functions: Δ T=Fj-Fi;If Δ T < 0, then input parameter and needle position of cusp are adjusted to j state;If Δ T > 0, inputting parameter or needle position of cusp at this time can be with exp(-ΔT/Ti) be adjusted;
D. annealing temperature T is calculatedi+1=α Ti, α is the coefficient for controlling annealing temperature decrease speed, if annealing temperature Ti+1Not up to most Low temperature then continues step b, if annealing temperature Ti+1Reach minimum temperature, judges whether there is the target spot not inactivated;Such as Fruit has, and carries out step b and starts new round iteration;If it is not, input power P and heating time t after output optimization.
CN201810944806.4A 2018-08-19 2018-08-19 A kind of Microwave Coagulation Therapy method of planning based on ct images Pending CN109077804A (en)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109758227A (en) * 2019-01-23 2019-05-17 广州安泰创新电子科技有限公司 Tumour ablation analogy method, device, electronic equipment and readable storage medium storing program for executing
CN110517782A (en) * 2019-09-17 2019-11-29 浙江德尚韵兴医疗科技有限公司 The microwave ablation ablation stove rapid simulation method and system calculated based on specific absorption rate
CN110731821A (en) * 2019-09-30 2020-01-31 艾瑞迈迪医疗科技(北京)有限公司 Method and guide bracket for minimally invasive tumor ablation based on CT/MRI
CN110739084A (en) * 2019-10-24 2020-01-31 李萍 Virtual reality interaction system and interaction method
CN110811831A (en) * 2019-05-27 2020-02-21 苏州六莲科技有限公司 Accurate automatic evaluation method and device for kidney surgery
CN110942832A (en) * 2019-12-11 2020-03-31 南京亿高微波系统工程有限公司 Microwave ablation system
CN111653363A (en) * 2020-06-23 2020-09-11 南京诺源医疗器械有限公司 Curative effect evaluation method in microwave ablation based on simulated temperature field
CN112007289A (en) * 2020-09-09 2020-12-01 上海沈德医疗器械科技有限公司 Automatic planning method and device for tissue ablation
CN112790858A (en) * 2020-12-31 2021-05-14 杭州堃博生物科技有限公司 Ablation parameter configuration method, device, system and computer readable storage medium
CN113181563A (en) * 2021-04-30 2021-07-30 珠海横乐医学科技有限公司 Method, system and medium for planning radiotherapy dose in particle implantation tumor
CN113693725A (en) * 2021-10-22 2021-11-26 杭州维纳安可医疗科技有限责任公司 Needle insertion path planning method, device, equipment and storage medium
CN114007538A (en) * 2019-06-27 2022-02-01 康坦手术股份有限公司 Deep learning-based method for planning tissue ablation
CN114557770B (en) * 2022-02-23 2023-10-03 上海精劢医疗科技有限公司 Interactive path planning method and system for microwave ablation operation

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109758227A (en) * 2019-01-23 2019-05-17 广州安泰创新电子科技有限公司 Tumour ablation analogy method, device, electronic equipment and readable storage medium storing program for executing
CN110811831A (en) * 2019-05-27 2020-02-21 苏州六莲科技有限公司 Accurate automatic evaluation method and device for kidney surgery
CN114007538A (en) * 2019-06-27 2022-02-01 康坦手术股份有限公司 Deep learning-based method for planning tissue ablation
CN114007538B (en) * 2019-06-27 2024-03-29 康坦手术股份有限公司 Deep learning-based planning tissue ablation method
CN110517782B (en) * 2019-09-17 2022-07-12 浙江德尚韵兴医疗科技有限公司 Microwave ablation range rapid simulation method and system based on specific absorption rate calculation
CN110517782A (en) * 2019-09-17 2019-11-29 浙江德尚韵兴医疗科技有限公司 The microwave ablation ablation stove rapid simulation method and system calculated based on specific absorption rate
CN110731821A (en) * 2019-09-30 2020-01-31 艾瑞迈迪医疗科技(北京)有限公司 Method and guide bracket for minimally invasive tumor ablation based on CT/MRI
CN110739084A (en) * 2019-10-24 2020-01-31 李萍 Virtual reality interaction system and interaction method
CN110942832A (en) * 2019-12-11 2020-03-31 南京亿高微波系统工程有限公司 Microwave ablation system
CN110942832B (en) * 2019-12-11 2024-02-20 南京亿高医疗科技股份有限公司 Microwave ablation system
CN111653363A (en) * 2020-06-23 2020-09-11 南京诺源医疗器械有限公司 Curative effect evaluation method in microwave ablation based on simulated temperature field
CN112007289A (en) * 2020-09-09 2020-12-01 上海沈德医疗器械科技有限公司 Automatic planning method and device for tissue ablation
CN112790858A (en) * 2020-12-31 2021-05-14 杭州堃博生物科技有限公司 Ablation parameter configuration method, device, system and computer readable storage medium
CN112790858B (en) * 2020-12-31 2021-11-09 杭州堃博生物科技有限公司 Ablation parameter configuration method, device, system and computer readable storage medium
CN113181563B (en) * 2021-04-30 2023-01-03 珠海横乐医学科技有限公司 Method, system and medium for planning radiotherapy dose in particle implantation tumor
CN113181563A (en) * 2021-04-30 2021-07-30 珠海横乐医学科技有限公司 Method, system and medium for planning radiotherapy dose in particle implantation tumor
CN113693725B (en) * 2021-10-22 2022-02-22 杭州维纳安可医疗科技有限责任公司 Needle insertion path planning method, device, equipment and storage medium
CN113693725A (en) * 2021-10-22 2021-11-26 杭州维纳安可医疗科技有限责任公司 Needle insertion path planning method, device, equipment and storage medium
CN114557770B (en) * 2022-02-23 2023-10-03 上海精劢医疗科技有限公司 Interactive path planning method and system for microwave ablation operation

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Application publication date: 20181225