CN109077801A - The diagnosis and treatment method and system of multi-source information guidance laser ablation - Google Patents
The diagnosis and treatment method and system of multi-source information guidance laser ablation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00904—Automatic detection of target tissue
Abstract
The invention discloses the diagnosis and treatment methods and system of a kind of multi-source information guidance laser ablation, wherein, method is the following steps are included: obtain medicine multi-source information or multi-modal information, and quantify biological tissue and pathological tissues, and obtain the structure function information of the three-dimensional border structure and pathological tissues current in art of pathological tissues；Laser ablation output parameter is obtained by laser ablation pathological tissues ablation, and the quantitative analysis of biological pathological tissues is combined to adjust laser ablation output parameter；Laser ablation output parameter is guided according to multi-source information, to carry out laser ablation treatment.This method judges coupling matching laser ablation output parameter during lesion by using various dimensions multi-source information, realizes real-time laser ablation treatment, so that the real-time of diagnosis and treatment, accuracy and applicability are effectively increased, it is simple easily to realize.
Description
Technical field
The present invention relates to medical images to guide laser ablation treatment technology field, in particular to a kind of multi-source information guidance swashs
The diagnosis and treatment method and system of light ablation.
Background technique
With the continuous improvement of Biologic Medical Image and intellectual treatment technology, the treatment of modern tumour or lesion has been needed
Operation is gradually changed into minimally invasive intellectual treatment mode to implement, it is desirable that while being accurately positioned surgical site position,
Reduction as much as possible is to the normal tissue of patient and the wound of physiological function, to evade the hand that open surgery is left
The problems such as art wound is big, convalescence is long will be preferably minimized biological tissue and physiological function injury, and reduce wound and restore week
Time phase.Tumour has become the big killer for threatening human health, because high lethality rate caused by it is paid close attention to by people.
Operation is the prefered method of current tumour and lesions treatment.But being most difficult to solve the problems, such as in operation at present is
Problem is precisely treated in the accurate judgement of tumor boundaries and art.Therefore, exploitation has the multi-modal structure and function shadow across scale
Have great importance as accurately image guidance will be provided for operation.Accurately multi-modal image-guided intelligent laser
Ablation can accurately target positioning operation region, can realize the features such as guiding in monitoring and art in the course of surgery, meanwhile,
It is proposed the framework of functional image, on the basis of structure image to guarantee completely save functional area in surgical procedure.
Such diagnosis and treatment equipment has the advantages that diagnosis and treatment integration, wound is small, wound recovery is fast, intelligence degree is high, good effect.
Currently, multi-modal image-guided operative treatment brings very big progress to tumour or lesions treatment, make
The success rate of operation must be greatly improved and reduce postoperative recurrence rate.Also increase in conjunction with the diagnosis of the functional information in art
Success rate of operation and the wound for reducing physiological function, but in operative treatment mode depend critically upon doctors experience, to facing
The few doctor of bed surgical experience realizes that high accurately operative treatment will have great challenge.Therefore, developing intellectual resource is examined
It treats equipment to have great importance for operative doctor and surgeon, while realizing intelligentized digital diagnosis and treat equipment energy
Enough huge Gospel is brought for the remote operation in future.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.
For this purpose, an object of the present invention is to provide a kind of diagnosis and treatment method of multi-source information guidance laser ablation, the party
Method effectively increases the real-time, accuracy and applicability of diagnosis and treatment, simple easily to realize.
It is another object of the present invention to the diagnosis and therapy systems for proposing a kind of multi-source information guidance laser ablation.
In order to achieve the above objectives, one aspect of the present invention embodiment proposes a kind of diagnosis and treatment of multi-source information guidance laser ablation
Method, comprising the following steps: medicine multi-source information or multi-modal information are obtained, and quantifies biological tissue and pathological tissues, and
Obtain the structure function information of current pathological tissues in the three-dimensional border structure and art of the pathological tissues；Pass through laser ablation disease
Become ablation of tissue to treat to obtain laser ablation output parameter, and adjusts the laser in conjunction with the quantitative analysis of biological pathological tissues
Melt output parameter；The laser ablation output parameter is guided according to the multi-source information, to carry out laser ablation treatment.
The diagnosis and treatment method of the multi-source information guidance laser ablation of the embodiment of the present invention, is sentenced by using various dimensions multi-source information
Coupling matching laser ablation output parameter during disconnected lesion realizes real-time laser ablation treatment, and reaches accurately micro-
The efficiently high accurate lesions treatment of wound, the Efficient intelligent that tumour or lesion not only may be implemented precisely diagnoses, but also may be implemented
The real-time treatment of lesion reaches efficiently high accurately intellectual treatment, and can acquire the real time imagery in art, to effectively mention
The high real-time of diagnosis and treatment, accuracy and applicability are simple easily to realize.
In addition, the diagnosis and treatment method of multi-source information according to the above embodiment of the present invention guidance laser ablation can also have with
Under additional technical characteristic:
Further, in one embodiment of the invention, the multi-source information includes preoperative medical image, art traditional Chinese medicine
Information in image and art, and the laser ablation output parameter includes laser radiation power, laser output duration, laser spy
One of head and height and laser probe the rotation angle of biological tissue are a variety of.
Further, in one embodiment of the invention, further includes: draw lesion boundary and quantify the function of Pathological Information
It can effect；Lesion boundary in blood flow function, art in detection technique, nervous function information in art.
Further, in one embodiment of the invention, the quantitative analysis of the combination biology pathological tissues adjusts institute
Laser ablation output parameter is stated, further comprises: being analyzed and is constructed the size and pathological tissues quantization of lesion region, wherein
The three-dimensional lesion region and boundary that art Small and Medium Sized is completed on the diagnostic base of preoperative structure image construct, and establish in art
Functional information is corresponding with mechanics of biological tissue.
Further, in one embodiment of the invention, further includes: obtaining the preoperative amount with image and information in art
Change and analyzes and after laser ablation output parameter group, construct the mapping relations based on image information Yu laser ablation parameter group, and
Building laser ablation couples ablation path, to guide the coupling ablation path in tumour or lesion according to the mapping relations
Implement laser output treatment in position.
In order to achieve the above objectives, another aspect of the present invention embodiment proposes a kind of examining for multi-source information guidance laser ablation
Treatment system, comprising: data obtaining module for obtaining medicine multi-source information or multi-modal information, and quantifies biological tissue and disease
Become tissue, and obtains the structure function information of the three-dimensional border structure and pathological tissues current in art of the pathological tissues；Swash
Light ablation parameter module for obtaining laser ablation output parameter by laser ablation pathological tissues ablation, and combines
The quantitative analysis of biological pathological tissues adjusts the laser ablation output parameter；Guiding module, for according to the multi-source information
The laser ablation output parameter is guided, to carry out laser ablation treatment.
The diagnosis and therapy system of the multi-source information guidance laser ablation of the embodiment of the present invention, is sentenced by using various dimensions multi-source information
Coupling matching laser ablation output parameter during disconnected lesion realizes real-time laser ablation treatment, and reaches accurately micro-
The efficiently high accurate lesions treatment of wound, the Efficient intelligent that tumour or lesion not only may be implemented precisely diagnoses, but also may be implemented
The real-time treatment of lesion reaches efficiently high accurately intellectual treatment, and can acquire the real time imagery in art, to effectively mention
The high real-time of diagnosis and treatment, accuracy and applicability are simple easily to realize.
In addition, the diagnosis and therapy system of multi-source information according to the above embodiment of the present invention guidance laser ablation can also have with
Under additional technical characteristic:
Further, in one embodiment of the invention, the multi-source information includes preoperative medical image, art traditional Chinese medicine
Information in image and art, and the laser ablation output parameter includes laser radiation power, laser output duration, laser spy
One of head and height and laser probe the rotation angle of biological tissue are a variety of.
Further, in one embodiment of the invention, further includes: drafting module, for drawing lesion boundary and amount
Change the functional effect of Pathological Information；Detection module, for neural function in the blood flow function in detection technique, lesion boundary in art, art
It can information.
Further, in one embodiment of the invention, the ablation module is further used for analyzing and constructs lesion
The size and pathological tissues in region quantify, wherein complete the solid of art Small and Medium Sized on the diagnostic base of structure image in the preoperative
Lesion region and boundary construct, and it is corresponding with mechanics of biological tissue to establish in art functional information.
Further, in one embodiment of the invention, further includes: building module, in obtaining preoperative and art
After the quantization and analysis and laser ablation output parameter group of image and information, building is based on image information and laser ablation parameter group
Mapping relations, and construct laser ablation couples ablation path, to guide coupling ablation road according to the mapping relations
Diameter implements laser output treatment in tumour or diseased region.
The additional aspect of the present invention and advantage will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Detailed description of the invention
Above-mentioned and/or additional aspect and advantage of the invention will become from the following description of the accompanying drawings of embodiments
Obviously and it is readily appreciated that, in which:
Fig. 1 is the flow chart that the diagnosis and treatment method of laser ablation is guided according to the multi-source information of one embodiment of the invention；
Fig. 2 is the process that the diagnosis and treatment method of laser ablation is guided according to the multi-source information of one specific embodiment of the present invention
Figure；
Fig. 3 is to construct schematic diagram according to the multimodal information of one embodiment of the invention and the relationship of laser output parameter；
Fig. 4 is the road for biological tissue that laser ablation treatment is guided according to the multi-source information of one embodiment of the invention
Diameter plans schematic diagram；
Fig. 5 is to be guided laser ablation treatment with lateral parameter for life according to the multi-source information of one embodiment of the invention
The laser ablation path planning schematic diagram of object tissue；
Fig. 6 is the structural representation that the diagnosis and therapy system of laser ablation is guided according to the multi-source information of one embodiment of the invention
Figure.
Specific embodiment
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention.
The diagnosis and treatment method of the multi-source information proposed according to embodiments of the present invention guidance laser ablation is described with reference to the accompanying drawings
And system, the diagnosis and treatment side of the multi-source information proposed according to embodiments of the present invention guidance laser ablation is described with reference to the accompanying drawings first
Method.
Fig. 1 is the flow chart of the diagnosis and treatment method of the multi-source information guidance laser ablation of one embodiment of the invention.
As shown in Figure 1, the multi-source information guidance laser ablation diagnosis and treatment method the following steps are included:
In step s101, medicine multi-source information or multi-modal information are obtained, and quantifies biological tissue and pathological tissues, and
And obtain the structure function information of the three-dimensional border structure and pathological tissues current in art of pathological tissues.
It is understood that multi-dimensional optical image and information diagnosis in preoperative art, obtain the multi-source information of lesion identification,
Realize the identification and boundary demarcation of lesion in the preoperative, and to realized during operation diagnosis in real time and the identification of pathological tissues with
Diagnosis.That is to say, the acquisition of medicine multi-source information or multi-modal information diagnoses, quantifies biological tissue and pathological tissues, give simultaneously
Provide the structure function information of pathological tissues in the three-dimensional border structure of pathological tissues and art in real time out.
As shown in Fig. 2, multi-modal image in preoperative art (CT (Computed Tomography, computed tomography)/
The preoperative images such as MRI (Magnetic Resonance Imaging, magnetic resonance imaging)/ultrasound), operation pathway planning and operation
It navigates and (operation pathway is realized under the guidance of image plan in the preoperative, find suitable operative approach), in accurate operation pathway
Guide image in lower art (pathological changes diagnosis in optical image and functional information acquisition and the art based on multi-source information in art).In diagnosis and treatment
In the process, based on MRI, CT, PET, (Positron Emission Computed Tomography, positron emission are calculated
Machine tomography) and the preoperative image of ultrasound etc. large scale, multi-modal image collection are realized to biological tissue and obtained, by lesion
Image precisely identify and analyze the accurate fusion for reaching structure function image information, and there is micron-sized spatial resolution,
Image taking speed is fast, and imaging depth reaches grade；Perspective effect also is formed with noninvasive depth radiationless, that tissue can be detected simultaneously
The features such as stereochemical structure image of fruit.
Further, in one embodiment of the invention, multi-source information includes preoperative medical image, art traditional Chinese medicine image
And information in art.
It is understood that in art multi-source information have the diagnosis of biological tissue's small-scale structure image and functional information with
Identification, gives the quantitative analysis of lesion region.Multi-source information contains preoperative medical image, which realizes wide field large scale
Imaging in biological tissues, multi-source information further comprise information in art traditional Chinese medicine image and art, and the image and information have in art quickly
Diagnosis effect.
That is, there is the medical images effect such as preoperative wide field large scale, multi-modal in the diagnosis of multi-source information, and
The operations such as multi-modal Image Segmentation, fusion registration are realized in preoperative image, complete preoperative large scale diagnosis.Multi-source is believed in art
Breath contains accurately fast imaging, acquisition of information in art, and information contains biological tissue's pathological structure function in art therein
Information, and precisely diagnosis and lesion identification in art is realized by parser in reasonable art.
Specifically, as shown in figure 3, there is the medicine shadow such as preoperative wide field large scale, multi-modal in the diagnosis of multi-source information
As effect, and the operations such as multi-modal Image Segmentation, fusion registration are realized in image in the preoperative, complete preoperative large scale and examine
It is disconnected.Multi-source information contains accurately fast imaging, acquisition of information in art in art, and information contains biological tissue in art therein
Pathological structure functional information, OCT (Optical Coherence tomography, light can be used in the extraction of information in such art
Coherence tomography system), PAT (Photoacoustic Tomography, Photoacoustic tomography), fluorescence imaging, fluorescence light
Information collection is realized in the medicine art such as spectrum, Raman spectrum, electrophysiologic monitoring, and is realized in art by parser in reasonable art
Precisely diagnosis is identified with lesion, preoperative art in information can be obtained in conventional medical inspection, it is real for specific lesion
Deep inspection is further realized in now preliminary screening and analysis.
Preoperative image can realize the navigation and planning of laser ablation operative treatment in display, realize in conjunction with surgery planning
The targeting of diseased region positions, and realizes minimally invasive open accurate treatment while treatment, in diagnostic imaging in the preoperative, base
It can be improved or change current diagnostic mode in the accurate diagnosis of artificial intelligence, be based especially on the diagnosis algorithm of deep learning
The experience of comprehensive multidigit expert doctor is realized into high efficiency height accurately pathological changes diagnosis and precisely identification, is reached even beyond expert
The diagnostic result of doctor.
Further, in one embodiment of the invention, further includes: draw lesion boundary and quantify the function of Pathological Information
It can effect；Lesion boundary in blood flow function, art in detection technique, nervous function information in art.
It is understood that realizing preoperative diagnosis using based on artificial intelligence approach, lesion boundary and quantization lesion are drawn
The functional effect of information；It further include blood flow function in art, lesion boundary alignment in art, the function such as nervous function information extraction in art
It can information judgement.Wherein, the diagnosis of preoperative image has the boundary direction of the depth direction based on deep learning and surface direction
Diagnosis and the drafting of diseased region overall structure image and lesion borderline region.
Specifically, imaging will be declined with after acquisition of information based on picture structure textural characteristics, spectral characteristic, optics in art
The identification and extraction of neoplastic lesion feature, intelligentized identification tumour or Pathological Information in the art subtracted etc..Imaging and information in art
The boundary real-time diagnosis that tumour or lesion in art will be provided and identification are obtained, meanwhile, position the functional information of biological tissue
With the mapping relations at limbs end, assist keeping physiological function in post laser therapeutic process；Reach in conjunction with physiological function analysis
Accurately blood flow acquisition or the acquisition and acquisition of blood flow velocity further obtain the metabolic condition of biological tissue, analysis disease
Become the lesion degree of tissue.
To sum up, the accurately drafting on tumour or lesion boundary and Pathological Information are realized based on preoperative large scale wide field image
Quantization, while providing the physiological function location information in art, the information such as vascular distribution state, blood flow, nervous function letter
Breath etc., obtains the structure function image of biological tissue, and determines treatment region according to the structure function image of biological tissue, and
It is scanned in treatment region to obtain quasi real time image.
In step s 102, laser ablation output parameter is obtained by laser ablation pathological tissues ablation, and tied
The quantitative analysis of symphysis object pathological tissues adjusts laser ablation output parameter.
It is understood that reasonably selecting suitable laser ablation parameter group, controlled based on the ablation of laser ablation pathological tissues
Treatment provides laser therapy ablation output parameter, defeated in combination with the suitable laser ablation of quantitative analysis control of biological pathological tissues
Parameter out.
Specifically, as shown in Fig. 2, the control of laser ablation output parameter is (to laser under diagnosis guidance in the preoperative/art
Output parameter control reaches accurately ablation), (observation swashs with information collection real-time monitoring laser ablation effect for imaging in art
The structure image and functional information of biological tissue after light ablation).Disappeared based on laser ablation output parameter real-time control laser
Melt treatment, which mainly realizes that specific ablation of tissue is treated according to actual ablation areas, for specific biological tissue
Laser ablation output parameter is adjusted, adjusted in real time in art according to output parameter and is further analyzed.Laser ablation treatment swashs
Light output parameter group can provide further accurately laser ablation therapeutic effect to the laser ablation treatment of biological tissue.
It, will be in the art based on picture structure textural characteristics, spectral characteristic, optical attenuator etc. after imaging is with acquisition of information in art
The identification and extraction of neoplastic lesion feature, intelligentized identification tumour or Pathological Information.Imaging will with acquisition of information in art
The boundary real-time diagnosis and identification of tumour or lesion in art are provided, meanwhile, position functional information and the limbs end of biological tissue
Mapping relations assist keeping physiological function in post laser therapeutic process；Reach accurately blood flow in conjunction with physiological function analysis
Amount acquisition or the acquisition and acquisition of blood flow velocity, and the metabolic condition of biological tissue is obtained, analyze the lesion degree of pathological tissues.
Further, in one embodiment of the invention, disappear in conjunction with the quantitative analysis adjustment laser of biological pathological tissues
Melt output parameter, further comprise: analyzing and construct the size and pathological tissues quantization of lesion region, wherein structure in the preoperative
The three-dimensional lesion region and boundary that art Small and Medium Sized is completed on the diagnostic base of image construct, and functional information is established in art
It is corresponding with mechanics of biological tissue.
It is understood that the lesion quantification of information is analyzed in preoperative image and art, specifically include: the size of lesion region
It is constructed with pathological tissues quantitative analysis, completes the three-dimensional lesion region of art Small and Medium Sized on the diagnostic base of structure image in the preoperative
It is constructed with boundary, while it is corresponding with mechanics of biological tissue to establish in art functional information.
Further, in one embodiment of the invention, laser ablation output parameter includes laser radiation power, laser
One of output duration, laser probe and the height of biological tissue and laser probe rotation angle are a variety of.
It is understood that laser ablation output parameter, which is adjusted, realizes precisely treatment, specifically include: laser radiation power,
The factors such as laser output duration, laser probe and the height of biological tissue, laser probe rotation angle.Wherein, laser spoke
It penetrates power and the duration is the intrinsic customized parameter of laser, laser equipment can be used directly to adjust for the adjusting of power and duration
Save or make output adjusting of computerizeing control；The height of laser probe and biological tissue, laser probe rotation angle are all outer
Adjustment parameter to be given needed for portion's headend equipment is highly filled with needing to assist specific headend equipment in the adjustment process of angle
It sets.
Specifically, laser ablation treatment needs to realize accurately laser parameter control using suitable ablation output parameter
System, so that reaching efficiently high in ablation procedure accurately treats tumour or lesion region.Laser output parameter mainly includes
Laser output radiation power, laser output duration, laser probe and the height of biological tissue, laser probe rotate angle
Etc. factors.
Wherein, the pathological changes diagnosis in art and identification will provide real-time image-guided information abundant or function knot
Structure guidance information realize the control of laser ablation parameter with couple, specifically include: laser radiation power and duration are laser
Laser equipment can be used directly to adjust or make to computerized control defeated for the adjusting of intrinsic customized parameter, power and duration
It adjusts out；The height of laser probe and biological tissue, laser probe rotation angle are all to be given needed for outer front end equipment
Adjustment parameter, highly with need to assist specific headend equipment device in the adjustment process of angle.
In step s 103, laser ablation output parameter is guided according to multi-source information, to carry out laser ablation treatment.
It is understood that the laser output parameter control of combination multi-source information of embodiment of the present invention guidance laser ablation
Diagnosis and treatment method, the simple and easily operated front-end architecture of development structure simultaneously realize multi-source information guidance laser ablation treatment, thus
It realizes to the accurate ablation of lesion.As shown in Fig. 2, the guidance observation lesion locations of image are until pathological tissues are treated in art
It completes and (terminates laser output, complete ablation).
Further, in one embodiment of the invention, further includes: obtaining the preoperative amount with image and information in art
Change and analyzes and after laser ablation output parameter group, construct the mapping relations based on image information Yu laser ablation parameter group, and
Building laser ablation couples ablation path, to guide coupling ablation path to implement in tumour or diseased region according to mapping relations
Laser output treatment.
It is understood that mapping relations are mainly based upon the tumour of multi-source information or lesion boundary quantifies and laser ablation
The structuring coupling of output parameter tissue with it is corresponding, and to designing corresponding front end mechanism realization image/letter in coupling process
The suitable output of breath guidance laser ablation parameter, while reaching accurately ablation in the case where laser couples path.
Specifically, as shown in figure 4, integrated using objective computation method to the basic framework of diagnosis and therapy system,
In, in the preoperative and after the quantization of image in art and information and analysis and the calculating of laser ablation output parameter group, building is based on shadow
As the mapping relations of information and laser ablation parameter group, and construct laser ablation couples ablation path.In biological tissue
Laser ablation path has stereoscopic effect, and the tumour or diseased region position, laser ablation in particular for stereochemical structure are same
Path is coupled with important, the relationship between the path and laser output parameter is shown below:
Rtpath={ pi(ai,bi,ci),Li}={ pi(ai,bi,ci),(ti,pi,θi,Hi, i=1 ..., n wherein, Rtpath
It is the planning path of laser ablation, a, b, c are the horizontal and vertical ablation parameter of laser ablation model respectively；T, p, θ, H are sharp
Light radiation parameter, they are laser radiation power, irradiation duration, probe relative rotation angle and laser probe and life respectively
The height of object tissue surface.piIt is the center of each ablation parameter point in laser ablation process.
Mapping relations guidance laser ablation coupling ablation path between the multi-source information and laser ablation parameter of building exists
Tumour or diseased region implement laser output treatment, establish external ablation path, intermediate ablation path, inside in tumor region
Ablation path.Suitable laser ablation parameter group is set and starting point P is set1, laser probe will be according to the probe road of design
Diameter carries out, and finally reaches terminal Pk。
Further, the inner track of laser probe, intermediate path, outside are realized by control laser ablation output parameter
The laser parameter Structure Quantification in path and diagnosis and treatment control output；Power in the laser output parameter of inner track kind, the duration,
Probe height and rotation angle relative maximum, intermediate path suitably reduce output parameter, output parameter are arranged in external path
It is minimum.
As shown in figure 5, by multi-source information guidance laser ablation optics diagnosis and therapy system treatment after biological tissue in,
The structure of coronal-plane can clearly analyze that laser ablation couples path and laser ablation boundary and biological pathological tissues boundary
With degree.It can be it is further seen that coupling laser ablation path planning with lateral parameter after laser ablation on coronal-plane.
The path can more specifically embody the intellectual treatment of the multi-source information guidance laser ablation of coronal-plane in biological tissue's level
Process.
It should be noted that the image of micrometer resolution can be provided based on FD-OCT and fluorescence imaging and high light spectrum image-forming
Information guidance operation overcomes in the operation of existing ultrasonic, biological biopsy and guides and analyze, while can also reduce the radiation of CT
Property, overcome the resolution ratio defect of MRI, CT in art；The scanning mode, simple mechanism structure and the light channel structure that provide convenience,
Height reduces manufacturing cost, improves image taking speed using 2-D vibration mirror so that in the course of surgery being capable of guiding in real time operation
Implement.
The application scenarios of the embodiment of the present invention are mainly the excision of tumour, lesion, especially tumor boundaries and tumors remaining
Identification, such as the tumour (glioma, ependymoma, melanoma etc.) in the operation of neurosurgery.Probe has structure letter
Single, low in cost, lesions treatment is using simple, easy to operate, image taking speed is fast, image spatial resolution is high, small in size, quality
Gently, the advantages that image effect is obvious.
To sum up, the method for the embodiment of the present invention both can be to the stereochemical structure of soft tissue especially brain tissue and brain stem tissue
Functional imaging, and can be with resolving acquisition OCT and fluorescent high spectral image, and the real time imagery in art can be acquired, there is structure
Pathological Information is quantized into simple medical image and high, low in cost, easy to operate, the preoperative art of abundant information, intelligence degree
As speed is fast, diagnosis and treatment integrated degree hi-vision spatial resolution is high, small in size, based on diagnostic imaging precision, high, light weight is controlled
Therapeutic effect is obvious, small etc. advantage is damaged to physiological function in the obvious art of image effect.
The diagnosis and treatment method of the multi-source information guidance laser ablation proposed according to embodiments of the present invention is more by using various dimensions
Source information judges coupling matching laser ablation output parameter during lesion, realizes real-time laser ablation treatment, and reach
Accurately the minimally invasive efficient accurate lesions treatment of height, the Efficient intelligent that tumour or lesion not only may be implemented precisely diagnose, but also
The real-time treatment that lesion may be implemented reaches efficiently high accurately intellectual treatment, and can acquire the real time imagery in art, from
And the real-time, accuracy and applicability of diagnosis and treatment are effectively increased, it is simple easily to realize.
Referring next to the diagnosis and therapy system for the multi-source information guidance laser ablation that attached drawing description proposes according to embodiments of the present invention.
Fig. 6 is the structural schematic diagram of the diagnosis and therapy system of the multi-source information guidance laser ablation of one embodiment of the invention.
As shown in fig. 6, the diagnosis and therapy system 10 of multi-source information guidance laser ablation includes: data obtaining module 100, laser
Ablation parameter module 200 and guiding module 300.
Wherein, data obtaining module 100 is for obtaining medicine multi-source information or multi-modal information, and quantify biological tissue and
Pathological tissues, and obtain the structure function information of the three-dimensional border structure and pathological tissues current in art of pathological tissues.Laser
Ablation parameter module 200 is used to obtain laser ablation output parameter by laser ablation pathological tissues ablation, and combines
The quantitative analysis of biological pathological tissues adjusts laser ablation output parameter.Guiding module 300, which is used to be guided according to multi-source information, to swash
Light melts output parameter, to carry out laser ablation treatment.The system 10 of the embodiment of the present invention is by using various dimensions multi-source information
Judge coupling matching laser ablation output parameter during lesion, real-time laser ablation treatment is realized, to effectively improve
The real-time of diagnosis and treatment, accuracy and applicability are simple easily to realize.
Further, in one embodiment of the invention, multi-source information includes preoperative medical image, art traditional Chinese medicine image
And information in art, and laser ablation output parameter includes laser radiation power, laser output duration, laser probe and biology
One of height and laser probe rotation angle of tissue is a variety of.
Further, in one embodiment of the invention, the system 10 of the embodiment of the present invention further include: drafting module and
Detection module.
Wherein, drafting module is used to draw lesion boundary and quantify the functional effect of Pathological Information；Detection module, for examining
Survey the blood flow function in art, lesion boundary in art, nervous function information in art.
Further, in one embodiment of the invention, ablation module 300 is further used for analyzing and constructs diseased region
The size and pathological tissues in domain quantify, wherein complete the solid disease of art Small and Medium Sized on the diagnostic base of structure image in the preoperative
Become region and boundary to construct, and it is corresponding with mechanics of biological tissue to establish in art functional information.
Further, in one embodiment of the invention, the system 10 of the embodiment of the present invention further include: building module.
Wherein, module is constructed, for obtaining the preoperative quantization with image and information in art and analysis and laser ablation output parameter group
Afterwards, the mapping relations based on image information Yu laser ablation parameter group are constructed, and construct laser ablation couples ablation path, with
Coupling ablation path is guided to implement laser output treatment in tumour or diseased region according to mapping relations.
It should be noted that the explanation of the aforementioned diagnosis and treatment method embodiment to multi-source information guidance laser ablation is also fitted
The diagnosis and therapy system of multi-source information guidance laser ablation for the embodiment, details are not described herein again.
The diagnosis and therapy system of the multi-source information guidance laser ablation proposed according to embodiments of the present invention is more by using various dimensions
Source information judges coupling matching laser ablation output parameter during lesion, realizes real-time laser ablation treatment, and reach
Accurately the minimally invasive efficient accurate lesions treatment of height, the Efficient intelligent that tumour or lesion not only may be implemented precisely diagnose, but also
The real-time treatment that lesion may be implemented reaches efficiently high accurately intellectual treatment, and can acquire the real time imagery in art, from
And the real-time, accuracy and applicability of diagnosis and treatment are effectively increased, it is simple easily to realize.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include at least one this feature.In the description of the present invention, the meaning of " plurality " is at least two, such as two, three
It is a etc., unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (10)
1. a kind of diagnosis and treatment method of multi-source information guidance laser ablation, which comprises the following steps:
Medicine multi-source information or multi-modal information are obtained, and quantifies biological tissue and pathological tissues, and obtain the lesion group
The structure function information of current pathological tissues in the three-dimensional border structure and art knitted；
Laser ablation output parameter is obtained by laser ablation pathological tissues ablation, and combines the amount of biological pathological tissues
Change laser ablation output parameter described in analysis and regulation；And
The laser ablation output parameter is guided according to the multi-source information, to carry out laser ablation treatment.
2. the diagnosis and treatment method of multi-source information guidance laser ablation according to claim 1, which is characterized in that the multi-source letter
Breath includes information in preoperative medical image, art traditional Chinese medicine image and art, and the laser ablation output parameter includes laser emission
One of power, laser output duration, laser probe and height and laser probe rotation angle of biological tissue are more
Kind.
3. the diagnosis and treatment method of multi-source information guidance laser ablation according to claim 1, which is characterized in that further include:
It draws lesion boundary and quantifies the functional effect of Pathological Information；
Lesion boundary in blood flow function, art in detection technique, nervous function information in art.
4. the diagnosis and treatment method of multi-source information guidance laser ablation according to claim 1, which is characterized in that the combination is raw
The quantitative analysis of object pathological tissues adjusts the laser ablation output parameter, further comprises:
Analyze and construct the size and pathological tissues quantization of lesion region, wherein complete on the diagnostic base of structure image in the preoperative
It is constructed at the three-dimensional lesion region of art Small and Medium Sized and boundary, and establishes pair of functional information and mechanics of biological tissue in art
It answers.
5. the diagnosis and treatment method of multi-source information guidance laser ablation according to claim 1, which is characterized in that further include:
After obtaining preoperative quantization and analysis and laser ablation output parameter group with image and information in art, building is based on image
The mapping relations of information and laser ablation parameter group, and construct laser ablation couples ablation path, to be closed according to the mapping
System guides the coupling ablation path to implement laser output treatment in tumour or diseased region.
6. a kind of diagnosis and therapy system of multi-source information guidance laser ablation characterized by comprising
Data obtaining module for obtaining medicine multi-source information or multi-modal information, and quantifies biological tissue and pathological tissues, and
And obtain the structure function information of the three-dimensional border structure and pathological tissues current in art of the pathological tissues；
Laser ablation parameter module, for obtaining laser ablation output parameter by laser ablation pathological tissues ablation, and
And the laser ablation output parameter is adjusted in conjunction with the quantitative analysis of biological pathological tissues；And
Guiding module, for guiding the laser ablation output parameter according to the multi-source information, to carry out laser ablation treatment.
7. the diagnosis and therapy system of multi-source information guidance laser ablation according to claim 6, which is characterized in that the multi-source letter
Breath includes information in preoperative medical image, art traditional Chinese medicine image and art, and the laser ablation output parameter includes laser emission
One of power, laser output duration, laser probe and height and laser probe rotation angle of biological tissue are more
Kind.
8. the diagnosis and therapy system of multi-source information guidance laser ablation according to claim 6, which is characterized in that further include:
Drafting module, for drawing lesion boundary and quantifying the functional effect of Pathological Information；
Detection module, for nervous function information in the blood flow function in detection technique, lesion boundary in art, art.
9. the diagnosis and therapy system of multi-source information guidance laser ablation according to claim 6, which is characterized in that the ablation mould
Block is further used for analyzing and constructing the size of lesion region and pathological tissues quantify, wherein the diagnosis of structure image in the preoperative
On the basis of complete the three-dimensional lesion region of art Small and Medium Sized and boundary constructs, and functional information and biological tissue are established in art
The correspondence of structure.
10. the diagnosis and therapy system of multi-source information guidance laser ablation according to claim 6, which is characterized in that further include:
Module is constructed, for obtaining the preoperative quantization with image and information in art and analysis and laser ablation output parameter group
Afterwards, the mapping relations based on image information Yu laser ablation parameter group are constructed, and construct laser ablation couples ablation path, with
The coupling ablation path is guided to implement laser output treatment in tumour or diseased region according to the mapping relations.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875680A (en) * | 2019-02-18 | 2019-06-14 | 清华大学 | Total optical path intelligent optical diagnosis and therapy system based on optical-coherence tomography |
| CN110327016A (en) * | 2019-06-11 | 2019-10-15 | 清华大学 | Intelligent minimally invasive diagnosis and treatment integral system based on optical image and optical therapeutic |
| CN110570924A (en) * | 2019-08-26 | 2019-12-13 | 天津大学 | Tumor ablation-oriented remote diagnosis and treatment system and method |
| CN111067618A (en) * | 2019-12-31 | 2020-04-28 | 华科精准（北京）医疗科技有限公司 | Simulation method and device for laser interstitial thermotherapy |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310796A (en) * | 2007-05-22 | 2008-11-26 | 杜毅 | Weight reduction method and system for reducing fat |
| CN103796607A (en) * | 2011-09-13 | 2014-05-14 | 皇家飞利浦有限公司 | Ablation planning with lesion coverage feedback |
| CN105877910A (en) * | 2015-01-16 | 2016-08-24 | 上海交通大学 | Integrated system for accurate diagnosis and treatment of hardened blood vessels or tumors |
-
2018
- 2018-06-27 CN CN201810675326.2A patent/CN109077801B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310796A (en) * | 2007-05-22 | 2008-11-26 | 杜毅 | Weight reduction method and system for reducing fat |
| CN103796607A (en) * | 2011-09-13 | 2014-05-14 | 皇家飞利浦有限公司 | Ablation planning with lesion coverage feedback |
| CN105877910A (en) * | 2015-01-16 | 2016-08-24 | 上海交通大学 | Integrated system for accurate diagnosis and treatment of hardened blood vessels or tumors |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875680A (en) * | 2019-02-18 | 2019-06-14 | 清华大学 | Total optical path intelligent optical diagnosis and therapy system based on optical-coherence tomography |
| CN109875680B (en) * | 2019-02-18 | 2020-10-16 | 清华大学 | Common-path intelligent optical diagnosis and treatment system based on optical coherence tomography |
| CN110327016A (en) * | 2019-06-11 | 2019-10-15 | 清华大学 | Intelligent minimally invasive diagnosis and treatment integral system based on optical image and optical therapeutic |
| CN110570924A (en) * | 2019-08-26 | 2019-12-13 | 天津大学 | Tumor ablation-oriented remote diagnosis and treatment system and method |
| CN111067618A (en) * | 2019-12-31 | 2020-04-28 | 华科精准（北京）医疗科技有限公司 | Simulation method and device for laser interstitial thermotherapy |
| CN113995512A (en) * | 2021-02-07 | 2022-02-01 | 武汉光脉科技有限公司 | Full-automatic tracking minimally invasive laser ablation surgical robot system and treatment method thereof |
| CN114083112A (en) * | 2021-10-20 | 2022-02-25 | 泰德激光惠州有限公司 | Control method and device of laser ablation system and computer readable storage medium |
| CN114137901A (en) * | 2021-10-20 | 2022-03-04 | 泰德激光惠州有限公司 | Control method and device of laser ablation system and computer readable storage medium |
| CN114137902A (en) * | 2021-10-20 | 2022-03-04 | 泰德激光惠州有限公司 | Control method and device of laser ablation equipment and computer readable storage medium |
| CN116271563A (en) * | 2023-04-18 | 2023-06-23 | 广州市五合医疗器械有限公司 | Semiconductor laser therapeutic apparatus control method and system |
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