CN109063419B - A kind of gastric cancer genetic mutation and drug interpret multiple database interactive system - Google Patents

A kind of gastric cancer genetic mutation and drug interpret multiple database interactive system Download PDF

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CN109063419B
CN109063419B CN201810696303.XA CN201810696303A CN109063419B CN 109063419 B CN109063419 B CN 109063419B CN 201810696303 A CN201810696303 A CN 201810696303A CN 109063419 B CN109063419 B CN 109063419B
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gastric cancer
genetic mutation
database
drug
information
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CN109063419A (en
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杨达梅
杨丽
陈雷
黄梦珠
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MACCURA BIOTECHNOLOGY Co.,Ltd.
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Mackay Gene Technology Co Ltd
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage

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Abstract

The embodiment of the invention discloses a kind of gastric cancer genetic mutations and drug to interpret multiple database interactive system, comprising: gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer documentation & info database；Each database is for storing corresponding data；Wherein, gastric cancer medicament treatment data library includes gastric cancer genetic mutation and drug therapy approval in-formation database, gastric cancer genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug therapy clinical trials information database.By establishing multiple database interactive system, gastric cancer genetic mutation and drug related data can be stored, the interactive system data volume is perfect and easy to use.

Description

A kind of gastric cancer genetic mutation and drug interpret multiple database interactive system
Technical field
The present embodiments relate to field of computer technology, and in particular to a kind of gastric cancer genetic mutation and drug are interpreted most According to library interactive system.
Background technique
Gastric cancer (gastric carcinoma) is initiated by the malignant tumour of gastric epithelial, various pernicious swollen in China Disease incidence ranks first in tumor, and incidence gastric cancer has apparent region gender gap, sends out in the northwest in China and coastal region in east China gastric cancer Sick rate is evident as high than southern area.The hair age, the ratio between men and women's disease incidence was 2:1 at 50 years old or more well.Due to dietary structure Change, operating pressure increase and the reasons such as the infection of helicobacter pylori, so that rejuvenation tendency is presented in gastric cancer.Gastric cancer can occur In any position of stomach, wherein more than half betide antrum portion, greater curvature, lesser curvature and front and rear wall can be involved.Absolutely mostly Number gastric cancer belongs to gland cancer, early stage non-evident sympton, or the nonspecific symptoms such as epigastric discomfort, belch occurs, often bursts with gastritis, stomach The stomaches chronic disease symptom such as ulcer is similar, is easily ignored, and therefore, the early diagnostic rate of China's gastric cancer is still lower at present.Gastric cancer it is pre- It is related with the pathological staging of gastric cancer, position, organization type, biological behaviour and remedy measures afterwards.The classifying method of gastric cancer passes through Go through 3 important stages: the general form parting of nineteen twenty-three, the histopathology credit of nineteen sixty-five, four kinds of development in 2014 Genotype.Currently, the classification method of mainstream is mainly histopathologic classification and genotypic categorization, according to histopathology Gastric cancer can be divided into for gland cancer, adenosquamous carcinoma, squamous carcinoma, class cancer etc. by classification, and the overwhelming majority is sdenocarcinoma of stomach.By institutional framework difference, gland Cancer can also be divided into papillary carcinoma, tubular adenocarcinoma, poorly differentiated adenocarcinoma, mucinous adenocarcinoma and signet ring cell cancer.Not by cell differentiation Together, differentiated, middle differentiation, low 3 kinds of differentiation can be divided into.Visible peristalsis visible intestinal peristalsis and gastric pattern (diffusing type) can be divided by tissue origin；According to gene Gastric cancer can be divided into ebv infection type gastric cancer (EBV) by type classification, microsatellite instability is formed gastric cancer (MSII), genome is stablized Type gastric cancer (GS), chromosome instability sizing gastric cancer (CIN), four kinds of different molecular partings show different characterization of molecules.EBV Type accounts for about the 9% of all gastric cancers, shows as the mutation of PIK3CA gene high frequency and DNA high methylation and JAK2, PDL-1/2 Amplification and ARID1A, BCOR recurrent mutation；MIS type accounts for about the 22% of all gastric cancers, shows as mutation rate height, including coding target Gene mutation to oncogenic signals albumen has gastric pattern CIMP, MHL1 supermethylation；GS type accounts for about 20%, mostly diffuses type, deposits In RHOA gene mutation or RHO family GTP enzyme activation protein gene fusion phenomenon；CIN type, about 50%, mostly visible peristalsis visible intestinal peristalsis, significantly Heteroploid type and receptor tyrosine kinase activator mutation.Gastric cancer is made to be different from tradition in the treatment according to molecule parting is not had to Treatment selects individualized treatment, is the development trend of curing gastric cancer according to different molecule features.
As detected number of genes quicklys increase in patients with gastric cancer sample, clinical molecular laboratory testing is to increasingly More new certain illnesss of sequence variations and drug use are only related to individual gene mutation, and most illnesss and drug use Related to multiple gene mutations, contacting between genetic mutation and drug interpretation is very close and complicated, gives sequencing to some The clinical meaning of column variation carries out classification interpretation, and selection is specifically treated with optimal pharmaceutical admixtures, the individual for gastric cancer Changing medication guide is that current genetic test constantly faces new challenges in terms of sequence interpretation.
But the genetic mutation data of the magnanimity generated with the continuous development of two generation sequencing technologies, huge gene The processing and analysis of variation data and various forms data (drug, guide, clinical information, document etc.) are to realize that disease is precisely cured The emphasis for the treatment of.Currently, there is no the unified standard interpreted about gastric cancer genetic mutation and drug and databases, for dependency basis Because variation data interpretation and compile each major company and Clinical Institutions have different a processing method and process, therefore how Perfect and convenient to use gastric cancer genetic mutation and drug data base is established to be a problem to be solved.
Summary of the invention
Since existing method is there are the above problem, it is more that the embodiment of the present invention proposes that a kind of gastric cancer genetic mutation and drug are interpreted Database interaction system.
In a first aspect, the embodiment of the present invention proposes that a kind of gastric cancer genetic mutation and drug interpret multiple database interactive system, It include: gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer documentation & info database；
The gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and the gastric cancer documentation & info number It is connected two-by-two respectively according to library；
The gastric cancer genetic mutation information database is for storing the relevant data of gastric cancer genetic mutation；
Gastric cancer medicament treatment data library is for storing the treatment-related data of gastric cancer medicament；
The gastric cancer documentation & info database is for storing the relevant data of gastric cancer document；
Wherein, gastric cancer medicament treatment data library include: gastric cancer genetic mutation and drug therapy approval in-formation database, Gastric cancer genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug therapy clinical trials are believed Cease database.
In some embodiments, the system also includes: interpret reporting device；
The interpretation reporting device respectively with the gastric cancer genetic mutation information database, the gastric cancer medicament treatment data Library is connected with the gastric cancer documentation & info database, for interpreting to received judging result, is generated and is interpreted report.
In some embodiments, the system also includes: retrieval interpret result statistic device；
The interpretation result statistic device is treated with the gastric cancer genetic mutation information database, the gastric cancer medicament respectively Database, the gastric cancer documentation & info database connect with the interpretation reporting device, retrieves in each database for counting Gastric cancer genetic mutation Evidence grade relevant to drug, judges that the height of the Evidence grade obtains judging result, sentences described Disconnected result is sent to the interpretation reporting device, and receives the interpretation report of the interpretation reporting device feedback.
In some embodiments, the gastric cancer genetic mutation information database includes genetic mutation information database, stomach Cancer information database and gastric cancer medicament database；
The genetic mutation information database is selected from the group below one or more for storing: Gene Name, gene function Background introduction, chromosome location, transcript number, genetic mutation RS, signal path, genetic mutation nucleotide diversity locating for gene Information, genetic mutation amino acid variation information, sequence variations are in nucleotide and amino acid levels function prediction result；
The gastric cancer information database for store it is selected from the group below one or more: disease happening part, disease name, Occurrence cause, genius morbi, diagnostics method and index.
The gastric cancer medicament database is used to store disease therapeuticing medicine, including selected from the group below one or more: chemistry Other new types of therapeutic agents such as drug, target therapeutic agent, immunotherapy medicaments, gene therapy medicament.
In some embodiments, the gastric cancer genetic mutation is selected from drug therapy approval in-formation database for storing The following group it is one or more: Trade-name of drug, adopted name, indication information, application method, dosage and management, contraindication, Warning and precautionary measures, adverse reaction data, drug interaction and specific use crowd's information；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy approval in-formation database include two Layer, first layer are gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer genetic mutation is with drug therapy Consensus of experts information database for storing Diagnosis, treatment, monitoring and/or the prognosis information used with genetic mutation drug；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy Consensus of experts information database include Two layers, first layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer genetic mutation is with drug therapy clinical trials information database for storing Completed clinical test and clinical trial information in recruitment, including selected from the group below one or more: clinical research number is ground Study carefully title, research approach, mutation detection method, sample size, crowd characteristic, result of study and research conclusion；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy clinical trials information database include Two layers, first layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer documentation & info database is for selected from the group below one or more: storage Periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, result of study, research conclusion, Identification number PMID and the periodical IF factor；
Preferably, the information retrieval level of the gastric cancer documentation & info database includes two layers, and first layer is gastric cancer and base Because of the information that makes a variation, the second layer is genetic mutation information.
Second aspect, the embodiment of the present invention propose more data interactive methods based on above system, comprising:
The retrieval request of searching terminal is received, the retrieval request includes search key；
It interprets multiple database interactive system with gastric cancer genetic mutation and drug according to the retrieval request to interact, and root It interprets in multiple database interactive system and is retrieved in the gastric cancer genetic mutation and drug according to the search key, obtain stomach Oncogene variation and drug evidence；
It inquires default correlation table and obtains the correlation of gastric cancer genetic mutation with drug evidence, by the correlation and clinic Direct drug injection standard is compared, and obtains comparison result；
According to the comparison result, corresponding operation is executed.
The third aspect, the embodiment of the present invention propose a kind of more data interactive methods based on above system again, comprising:
The retrieval request of searching terminal is received, the retrieval request includes search key；
It interprets multiple database interactive system with gastric cancer genetic mutation and drug according to the retrieval request to interact, and root It is carried out in each database that the gastric cancer genetic mutation and drug interpret multiple database interactive system according to the search key Wide in range property retrieval, obtains each database gastric cancer genetic mutation Evidence grade relevant to drug according to the result of retrieval；
If Evidence grade is greater than preset value, the database that Evidence grade is greater than preset value is determined as target database, And the search result of target database is fed back into interpretation reporting device and is interpreted.
Fourth aspect, the present embodiment also propose a kind of more data interactive methods based on above system, comprising:
The original search instruction of searching terminal is received, the original search instruction includes search key；
Multiple database interactive system is interpreted with gastric cancer genetic mutation and drug according to the original search instruction to interact, And become according to the search key in the gastric cancer gene that the gastric cancer genetic mutation and drug interpret multiple database interactive system It is retrieved, is obtained in the genetic mutation information database of different information database, gastric cancer information database and gastric cancer medicament database To list of medications；
According to the list of medications and the search key in the gastric cancer genetic mutation and drug therapy approval in-formation It is retrieved in database, and presets correlation table according to the result queries of retrieval and obtain gastric cancer genetic mutation and drug evidence First correlation；
If first correlation is less than clinical direct drug injection standard, triggering first continues search instruction, and according to institute It states the first continuation search instruction and the search key and interprets multiple database interaction system in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer genetic mutation of system and drug therapy Consensus of experts information database, and by the result queries of the retrieval Default correlation table simultaneously merges with first correlation, obtains second correlation of the gastric cancer genetic mutation with drug evidence；
If second correlation is less than clinical direct drug injection standard, triggering second continues search instruction, and according to institute It states the second continuation search instruction and the search key and interprets multiple database interaction system in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer genetic mutation of system and drug therapy clinical trials information database, and by the result queries of the retrieval Default correlation table simultaneously merges with second correlation, obtains third correlation of the gastric cancer genetic mutation with drug evidence；
If the third correlation is less than the clinical direct drug injection standard, triggers third and continue search instruction, and root Continue search instruction and the search key according to the third and interprets multiple database friendship in the gastric cancer genetic mutation and drug Retrieved in the gastric cancer documentation & info database of mutual system, and by the result queries of the retrieval preset correlation table and with institute The merging of third correlation is stated, obtains the final search result of gastric cancer genetic mutation Yu drug evidence, and according to final search result Gastric cancer genetic mutation and drug are interpreted；
Wherein, in above procedure, when any one of first correlation, the second correlation, third correlation are greater than Or when being equal to clinical direct drug injection standard, then search program is terminated, and interpret to gastric cancer genetic mutation and drug.
In some embodiments, " merging " of the correlation, which can be, for example carries out phase for the correspondence score value of correlation Add, be averaged, be weighted and averaged, is preferably added.
In the context of the present invention, term " default correlation table " mean for various search results of the present invention and/ Or the correlation evidence that provides of one or more databases or for the situation (example summarized according to the search result/evidence Such as, " unscrambling data library-drug indication (CFDA) consistent with genetic mutation information is denoted as CS2；Second level unscrambling data library- Drug indication (other) consistent with genetic mutation information is denoted as OS2；Second level unscrambling data library-drug indication and gene Variation information inconsistent (CFDA) is denoted as the situations such as CN2 ") carry out the table that corresponding score value (i.e. Relevance scores) distribute.Some In embodiment, default correlation table can further include the table that correlation grading is carried out to final score value.
As shown from the above technical solution, the embodiment of the present invention is by establishing by gastric cancer genetic mutation information database, gastric cancer Medication data library and gastric cancer documentation & info database composition multiple database interactive system, for store genetic mutation and Drug related data, the multiple database interactive system data volume are perfect and easy to use.In another aspect of the invention, it provides A kind of sizing screening method of gastric cancer genetic mutation and drug-associated comprising following steps:
(1) gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer documentation & info data are established Library；Wherein
The gastric cancer genetic mutation information database is for storing the relevant data of gastric cancer genetic mutation；The gastric cancer medicament Treatment data library is for storing the treatment-related data of gastric cancer medicament；The gastric cancer documentation & info database is for storing gastric cancer text Offer relevant data；And wherein, gastric cancer medicament treatment data library includes: gastric cancer genetic mutation and drug therapy approval in-formation Database, gastric cancer genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug therapy clinical Test Information database；
(2) obtaining disease and/or genetic mutation in gastric cancer genetic mutation information database is search key, in gastric cancer medicine It is retrieved in object treatment data library and gastric cancer documentation & info database, obtains gastric cancer genetic mutation and drug relationship evidence, The evidence is separately stored in corresponding database that (for example, approval in-formation evidence is stored in approval in-formation database, expert is total Know information evidence and be stored in Consensus of experts information database, documentary evidence is stored in gastric cancer documentation & info database etc.)；
(3) it is scored based on the gastric cancer genetic mutation with drug relationship evidence；
(4) the being associated property of drug that the genetic mutation related disease is applicable in is classified according to overall score.
In some embodiments of above-mentioned sizing screening method, step (3) scoring only carries out primary；Preferably, Scoring retrieval described in step (2) carries out primary after being fully completed.In some embodiments, institute in step (2) It states and is retrieved as wide in range property retrieval, such as retrieved extensively in all databases, and be used to score by summarizing on evidence.It is excellent Selection of land, retrieval level described in step (2) include two layers, and first layer is gastric cancer and genetic mutation information, and the second layer is gene change Different information.
In some embodiments of above-mentioned sizing screening method, step (2) and (3) are sequentially carried out repeatedly, and each time Retrieval object database in step (2) is different, obtains overall score for step (4).
In some preferred embodiments, the method further includes:
(a) retrieval obtains list of medications corresponding with search key first from gastric cancer genetic mutation information database, Gastric cancer genetic mutation and drug therapy approval in-formation database are retrieved according to the list of medications, the card obtained according to retrieval According to progress first time scoring；Scoring is determined as overall score if scoring is greater than preset value and is classified, whole flow process is terminated； If scoring is less than preset value, continue step (b)；
(b) gastric cancer genetic mutation and drug therapy Consensus of experts information database are retrieved, is obtained according to retrieval Evidence carries out second and scores；Overall score is determined it as if first and second scoring summations are greater than preset value and is divided Grade terminates whole flow process；If first and second times scoring summation is less than preset value, continue step (c)；
(c) gastric cancer genetic mutation and drug therapy clinical trials information database are retrieved, is obtained according to retrieval Evidence carries out third time scoring；Overall score is determined it as if the preceding summation of scoring three times is greater than preset value and is classified, and is tied Beam whole flow process；If preceding scoring summation secondary three times is less than preset value, continue step (d)；
(d) gastric cancer documentation & info database is retrieved, the evidence obtained according to retrieval carries out the 4th scoring；By four Secondary scoring summation is determined as overall score and is classified, and terminates whole flow process.
In some embodiments, the gastric cancer genetic mutation information database includes genetic mutation information database, stomach Cancer information database and gastric cancer medicament database；
The genetic mutation information database is selected from the group below one or more for storing: Gene Name, gene function Background introduction, chromosome location, transcript number, genetic mutation RS, signal path, genetic mutation nucleotide diversity locating for gene Information, genetic mutation amino acid variation information, sequence variations are in nucleotide and amino acid levels function prediction result；
The gastric cancer information database for store it is selected from the group below one or more: disease happening part, disease name, Occurrence cause, genius morbi, diagnostics method and index.
The gastric cancer medicament database is used to store disease therapeuticing medicine, including selected from the group below one or more: chemistry Other new types of therapeutic agents such as drug, target therapeutic agent, immunotherapy medicaments, gene therapy medicament.
In some embodiments, the gastric cancer genetic mutation is selected from drug therapy approval in-formation database for storing The following group it is one or more: Trade-name of drug, adopted name, indication information, application method, dosage and management, contraindication, Warning and precautionary measures, adverse reaction data, drug interaction and specific use crowd's information；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy approval in-formation database include two Layer, first layer are gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer genetic mutation is with drug therapy Consensus of experts information database for storing Diagnosis, treatment, monitoring and the prognosis information used with genetic mutation drug；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy Consensus of experts information database include Two layers, first layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer genetic mutation is with drug therapy clinical trials information database for storing Completed clinical test and clinical trial information in recruitment, including selected from the group below one or more: clinical research number is ground Study carefully title, research approach, mutation detection method, sample size, crowd characteristic, result of study and research conclusion；
Preferably, the gastric cancer genetic mutation and the information retrieval level of drug therapy clinical trials information database include Two layers, first layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
In some embodiments, the gastric cancer documentation & info database is for selected from the group below one or more: storage Periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, result of study, research conclusion, Identification number PMID and the periodical IF factor；
Preferably, the information retrieval level of the gastric cancer documentation & info database includes two layers, and first layer is gastric cancer and base Because of the information that makes a variation, the second layer is genetic mutation information.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with Other attached drawings are obtained according to these figures.
Fig. 1 is that a kind of gastric cancer genetic mutation that one embodiment of the invention provides and drug interpret multiple database interactive system Connection schematic diagram；
Fig. 2 be another embodiment of the present invention provides a kind of gastric cancer genetic mutation and drug interpret multiple database interactive system Connection schematic diagram；
Fig. 3 is a kind of flow diagram for multiple database exchange method that one embodiment of the invention provides；
Fig. 4 is a kind of process signal for more data interactive methods based on wide in range retrieval that one embodiment of the invention provides Figure；
Fig. 5 is a kind of flow diagram of multiple database for providing of one embodiment of the invention successively exchange method.
Specific embodiment
With reference to the accompanying drawing, further description of the specific embodiments of the present invention.Following embodiment is only used for more Technical solution of the present invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
Fig. 1 shows a kind of gastric cancer genetic mutation provided in this embodiment and drug interprets multiple database interactive system, packet It includes: gastric cancer genetic mutation information database 101, gastric cancer medicament treatment data library 102 and gastric cancer documentation & info database 103.
The gastric cancer genetic mutation information database 101, gastric cancer medicament treatment data library 102 and the gastric cancer document Information database 103 connects two-by-two respectively.
The gastric cancer genetic mutation information database 101 is for storing the relevant data of gastric cancer genetic mutation.
Gastric cancer medicament treatment data library 102 is for storing the treatment-related data of gastric cancer medicament.
The gastric cancer documentation & info database 103 is for storing the relevant data of gastric cancer document.
Wherein, gastric cancer medicament treatment data library include: gastric cancer genetic mutation and drug therapy approval in-formation database, Gastric cancer genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug therapy clinical trials are believed Cease database.
The present embodiment is by establishing by gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer text The multiple database interactive system for offering information database composition, for storing genetic mutation and drug related data, the multiple database Interactive system data volume is perfect and easy to use.
Further, on the basis of the above embodiments, the system also includes: interpret reporting device and retrieval interpret knot Fruit statistic device.
The interpretation reporting device respectively with the gastric cancer genetic mutation information database, the gastric cancer medicament treatment data Library is connected with the gastric cancer documentation & info database, for interpreting to received judging result, is generated and is interpreted report.
The interpretation result statistic device is treated with the gastric cancer genetic mutation information database, the gastric cancer medicament respectively Database, the gastric cancer documentation & info database connect with the interpretation reporting device, retrieves in each database for counting Gastric cancer genetic mutation Evidence grade relevant to drug, judges that the height of the Evidence grade obtains judging result, sentences described Disconnected result is sent to the interpretation reporting device, and receives the interpretation report of the interpretation reporting device feedback.
Specifically, the present embodiment amounts to 6 databases, result statistic device is interpreted in 1 retrieval and 1 interpretation report dress It sets, all of above device constitutes complete gastric cancer genetic mutation and drug multidatabase system.It wherein, include 1 in 6 databases A Primary database is gastric cancer genetic mutation information database, and it includes three parts, first part is genetic mutation Information Number According to library, second part is gastric cancer information database, including but not limited to positions of gastric cancer, classification method, TNM stage, generation Reason, gastric cancer clinical manifestation, inspection diagnostic method, treatment method etc.；Third part is gastric cancer medicament database, includes gastric cancer Therapeutic agent includes but is not limited only to targeted drug, chemicals, immunotherapy medicaments, and data source is in third level data The drug information in library.
Wherein, the gene in the genetic mutation database is including but not limited to following:
HER2、VEGFR2、KRAS、PIK3CA、BRAF、NRAS、EGFR、TSC2、STK11、MTOR、VHL、KIT、 PDGFRB、PDGFRA、VEGFR1、VEGFR3、FLT3、RET、VEGF、MET、FGFR2、ATM、DPYD、GSTP1、UMPS、TYMS、 NQO1、CYP19A1、TP53、XPC、GSTM1、ERCC1、XRCC1、ACYP2、MTHFR、UGT1A1、SEMA3C、C8orf34、 FCGR2A、EPCAM、MLH1、MSH2、MSH6、PMS2、SMAD4、STK11、APC、ATC、BLM、RECQL3、BRCA1、BRCA2、 TP53、DDB2、ERCC2、ERCC3、ERCC4、ERCC5、hMLH1、MGMT、p16、TCF4、CDH1、FLNc、LOX、TIMP3、 TSP1、HoxD10、HAI-2/SPINT2、NDRG2、BNIP3、CACNA2D3、DAPK、GPX3、PCDH10、PCDH17、HLTF、 PAX6、ZNF545、RUNX3、RASSF1A、RASSF2、RKIP、SOCS-1、Dkk-3、RAR-β、KL、DACT1、BTG4、ECRG4、 EDNRB、LRP1B、TFPI2、CALCA、QKI、FAT4、ARID1A、PREX2、TGFBR2、KMT2C、KMT2D、CTNNB1、 TRRAP, PTPRT, RNF43, SPEN, ERBB3, ZFHX3, CREBBP, JAK2, RHOA, BCOR, variant form include but not only It is limited to point mutation, missing insertion, copy number variation, methylation, chromosome translocation rearrangement, microsatellite instability etc.；
Additionally include the site MSI: Bat25, Bat26, D5S346, D2S123, D17S250, D3S1260, D5S107, D5S409、D17S261、D17S520、D17S855、D18S34、BAT40、BAT-RII、NR21、NR22、NR24、NR27、 D18S34、D18S58、D1S548、D1S552、D5S346、TP53、IGFⅡR(G)8、IGFⅡR(CT)5、TGFBβR(GT)3、 TGFBβR(A)10、hMSH3(A)5、hMSH6(G)5、BAX(G)8。
Wherein therapeutic agent includes but are not limited to: Herceptin, Lei Molu monoclonal antibody, Ah pa replace Buddhist nun, Lapatinib, pa Trastuzumab, everolimus, bevacizumab, olaparib, TDM-1, Buddhist nun's trastuzumab, Cetuximab, Victibix, E Luo For Buddhist nun, Conmana, Gefitinib, Afatinib, Sorafenib, Sutent, Rui Gefeini, gram azoles for Buddhist nun, Onartuzumab, pa are received for Buddhist nun, more Weis for Buddhist nun, fluorouracil (5-FU), capecitabine, tegafur, gimeracil and oteracil potassium, oxaliplatin, the soft ratio of table Star, capecitabine, taxol, docetaxel, cis-platinum, carboplatin, Irinotecan, pyridine aldoxime methyliodide (PAM) monoclonal antibody, receive nurse monoclonal antibody, Aunar pearl monoclonal antibody, avelumab、duivalumab。
The present embodiment further includes 1 second databases, is gastric cancer medicament treatment data library, in gastric cancer medicament treatment data library Comprising three subdata bases, referred to as three-level database, three-level database 1, three-level database 2 and three series as shown in Figure 2 According to library 3, specifically comprising gastric cancer genetic mutation and drug therapy approval in-formation database, gastric cancer genetic mutation and drug therapy expert Consensus information database, gastric cancer genetic mutation and drug therapy clinical trials information database；1 level Four database gastric cancer document Information database, as shown in Figure 2.Retrieval interprets result statistic device and is responsible for counting second databases, three-level database, four series According to the gastric cancer genetic mutation and drug relevant evidence grade of library searching, and judge the height of Evidence grade, it is according to judgement as a result, anti- Instruction to the Primary database that feedback continues retrieval continues to complete retrieving or feedback result to interpreting reporting device, and obtains solution The interpretation report that reporting device is sent is read, solution read procedure is completed；Reporting device is interpreted to be responsible for receiving retrieval interpretation result statistics dress Instruction is set, final interpretation is completed, is formed and interpret report, completes to solve read procedure.
Wherein, Evidence grade be in medical domain for preventing, diagnosing, prognosis, treatment and harm research etc. evaluation etc. Grade, such as a set of Evidence grade that Oxford Evidence-Based Medicine Center proposes includes A grades of evidences, B grades of evidences, C grades of evidences and D grades of cards According to: Randomized controlled clinical study that A grades of evidences indicate consistent, are verified in different groups, cohort study, complete Or without the research of conclusion formula, clinical decision rule；B grades of evidences indicate consistent retrospective cohort study, perspective queue The conclusion that research, ecological Journal of Sex Research, outcome research, case-control study or the extrapolation of A grades of evidences obtain；C grades of evidences indicate The conclusion that the research of case sequence or B grades of evidences extrapolations obtain；D grades of evidences indicate the expert opinion of no key evaluation, or The evidence obtained based on basic medical research.
It is as follows that wherein there are correlations between 6 databases:
Wherein, Primary database is genetic mutation database, and second databases (the first level unscrambling data library) are gastric cancer Medication data library, three-level database include: approval data library (the second level unscrambling data library), common recognition database (third Level unscrambling data library) and clinical testing data library (the 4th level unscrambling data library), level Four database is gastric cancer documentation & info Database (layer 5 grade unscrambling data library).
Further, on the basis of the above embodiments, the gastric cancer genetic mutation information database includes genetic mutation Information database, gastric cancer information database, disease medicament information database.
The genetic mutation information database is selected from the group below one or more for storing: Gene Name, gene function Background introduction, chromosome location, transcript number, genetic mutation RS, signal path, genetic mutation nucleotide diversity locating for gene Information, genetic mutation amino acid variation information, sequence variations are in nucleotide and amino acid levels function prediction result.
The gastric cancer information database for store it is selected from the group below one or more: disease happening part, disease name, Occurrence cause, genius morbi, diagnostics method and index.
The gastric cancer medicament database is selected from the group below one or more for storing: disease therapeuticing medicine, including chemistry Other new types of therapeutic agents such as drug, target therapeutic agent, immunotherapy medicaments, gene therapy medicament.
In some preferred embodiments, in the genetic mutation information database including but not limited to following gastric cancer Related gene: HER2, VEGFR2, KRAS, PIK3CA, BRAF, NRAS, EGFR, TSC2, STK11, MTOR, VHL, KIT, PDGFRB、PDGFRA、VEGFR1、VEGFR3、FLT3、RET、VEGF、MET、FGFR2、ATM、DPYD、GSTP1、UMPS、TYMS、 NQO1、CYP19A1、TP53、XPC、GSTM1、ERCC1、XRCC1、ACYP2、MTHFR、UGT1A1、SEMA3C、C8orf34、 FCGR2A、EPCAM、MLH1、MSH2、MSH6、PMS2、SMAD4、STK11、APC、ATC、BLM、RECQL3、BRCA1、BRCA2、 TP53、DDB2、ERCC2、ERCC3、ERCC4、ERCC5、hMLH1、MGMT、p16、TCF4、CDH1、FLNc、LOX、TIMP3、 TSP1、HoxD10、HAI-2/SPINT2、NDRG2、BNIP3、CACNA2D3、DAPK、GPX3、PCDH10、PCDH17、HLTF、 PAX6、ZNF545、RUNX3、RASSF1A、RASSF2、RKIP、SOCS-1、Dkk-3、RAR-β、KL、DACT1、BTG4、ECRG4、 EDNRB、LRP1B、TFPI2、CALCA、QKI、FAT4、ARID1A、PREX2、TGFBR2、KMT2C、KMT2D、CTNNB1、 TRRAP,PTPRT,RNF43,SPEN,ERBB3,ZFHX3,CREBBP,JAK2,RHOA,BCOR；Its variant form includes but unlimited In point mutation, missing insertion, copy number variation, methylation, chromosome translocation rearrangement, microsatellite instability etc..In some realities Apply in scheme, the genetic mutation information may also include the following site MSI: Bat25, Bat26, D5S346, D2S123, D17S250、D3S1260、D5S107、D5S409、D17S261、D17S520、D17S855、D18S34、BAT40、BAT-RII、 NR21、NR22、NR24、NR27、D18S34、D18S58、D1S548、D1S552、D5S346、TP53、IGFⅡR(G)8、IGFⅡR (CT)5,TGFBβR(GT)3,TGFBβR(A)10,hMSH3(A)5,hMSH6(G)5,BAX(G)8.In further embodiment In, above-mentioned Associated Genes in Gastric Carcinoma and its variation information are built-in initial preset parameters in genetic mutation information database.
In some preferred embodiments, the disease therapeuticing medicine includes but is not limited to: Herceptin, Lei Molu Monoclonal antibody, Ah pa are single for Buddhist nun, Lapatinib, handkerchief trastuzumab, everolimus, bevacizumab, olaparib, TDM-1, the appropriate pearl of Buddhist nun Anti-, Cetuximab, Victibix, Tarceva, Conmana, Gefitinib, Afatinib, Sorafenib, Sutent, Rui Gefeini, gram azoles are received for Buddhist nun, Onartuzumab, pa and replace Buddhist nun for Buddhist nun, more Weis, fluorouracil (5-FU), capecitabine, replace Ji Austria, epirubicin, capecitabine, taxol, docetaxel, cis-platinum, carboplatin, Irinotecan, pyridine aldoxime methyliodide (PAM) monoclonal antibody, receives oxaliplatin Nurse monoclonal antibody, Aunar pearl monoclonal antibody, avelumab, duivalumab.In further embodiment, above-mentioned disease therapeuticing medicine is stomach Built-in initial preset parameter in cancer drug database.
Specifically, genetic mutation information database includes Gene Name, gene function background introduction, locating dyeing position It sets, signal path locating for transcript number, genetic mutation RS, gene, genetic mutation nucleotide diversity information (coding), gene Variant amino acid makes a variation information (protein), sequence variations are in nucleotide and amino acid levels function prediction result etc..Its information Retrieval mode is keyword: disease, is examined in each demographic data library, disease specific database and sequence database Rope, including but not limited to EAC, EVS, 1000Genomes Project, dbSNP, dbVar, ClinVar, OMIM, Human Gene Mutation Database、Human Genome Variation Society、Leiden Open Variation Database、DECIPHER、NCBI、RefSeqGene、Locus Reference Genomic(LRG)、MitoMap、 cosmic。
Gastric cancer information database includes but is not limited to disease happening part, disease name, occurrence cause, genius morbi, examines The disconnected related contents such as method and index.
Further, on the basis of the above embodiments, the gastric cancer genetic mutation and drug therapy approval in-formation data Library is selected from the group below one or more for storing: Trade-name of drug, adopted name, indication information, application method, bad Response data.
The gastric cancer genetic mutation and the information retrieval level of drug therapy approval in-formation database include two layers, first layer For gastric cancer and genetic mutation information, the second layer is genetic mutation information.
Specifically, the content stored in gastric cancer genetic mutation and drug therapy approval in-formation database includes drug trade name Title, adopted name, indication information, application method, dosage and management, contraindication, warning and precautionary measures, adverse reaction number According to, drug interaction and it is specific use crowd's information, information retrieval level is two layers, and first layer is disease+genetic mutation Information, the second layer are genetic mutation information, are retrieved in each food and medicine Surveillance Authority database and drug data base, Including but not limited to CFDA, FDA, EMA, PMDA.
Further, on the basis of the above embodiments, the gastric cancer genetic mutation and drug therapy Consensus of experts information Database is used to store diagnosis, treatment, monitoring and/or the prognosis information used with genetic mutation drug.
The gastric cancer genetic mutation and the information retrieval level of drug therapy Consensus of experts information database include two layers, the One layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
Specifically, the content stored in gastric cancer genetic mutation and drug therapy Consensus of experts information database includes recommending Diagnosis, treatment, monitoring, prognosis information for being used with genetic mutation drug etc..Its information retrieval level is two layers, and first layer is, Disease+genetic mutation information, the second layer are genetic mutation information, are retrieved in each accomplished expert's guide common recognition database, including But be not limited to NCCN, ASCO, CSCO, ESMO, each disease Consensus of experts.
Further, on the basis of the above embodiments, the gastric cancer genetic mutation and drug therapy clinical trials information Database is for storing completed clinical test and the clinical trial information in recruitment, including one selected from the group below or more : clinical research number, research title, research approach, mutation detection method, sample size, crowd characteristic, result of study and research Conclusion；
The gastric cancer genetic mutation and the information retrieval level of drug therapy clinical trials information database include two layers, the One layer is gastric cancer and genetic mutation information, and the second layer is genetic mutation information.
Specifically, the content stored in gastric cancer genetic mutation and drug therapy clinical trials information database includes being completed Clinical test and clinical trial information in recruitment, content includes selected from the group below one or more: clinical research number is ground Study carefully title, research approach, mutation detection method, sample size, crowd characteristic, result of study, research conclusion, information retrieval layer Grade is two layers, and first layer is disease+genetic mutation information, and the second layer is genetic mutation information, is carried out in clinical testing data library Inquiry, including but not limited to Clinicaltrails, medicine intelligence net, medicine cross net etc..
Further, on the basis of the above embodiments, the gastric cancer documentation & info database is selected from the group for storing It is one or more: periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, research knot Fruit, research conclusion, identification number PMID and the periodical IF factor.
The information retrieval level of the gastric cancer documentation & info database includes two layers, and first layer is that gastric cancer and genetic mutation are believed Breath, the second layer are genetic mutation information.
Specifically, the content stored in the gastric cancer documentation & info database includes selected from the group below one or more: the phase Print title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, result of study, research conclusion, PMID (ID number of PubMed document), the periodical IF factor, information retrieval level are two layers, and first layer is disease+genetic mutation Information, the second layer are genetic mutation information, are retrieved in major bibliographic data base, and including but not limited to pubmed, Google are learned Art etc..
The present embodiment interprets multiple database interactive system by establishing gastric cancer genetic mutation relevant to disease and drug, is The genetic mutation and drug of disease interpret interpretation standard, process and the model established.Can be quick with the multidatabase system, Accurately each variation is interpreted by different levels, interpretation standard is harsh to have science, is applicable to the essence of disease Quasi- treatment.
Fig. 3 shows a kind of flow diagram of multiple database exchange method provided in this embodiment, comprising:
S301, the retrieval request for receiving searching terminal, the retrieval request includes search key.
S302, it is handed over according to the retrieval request and gastric cancer genetic mutation and drug interpretation multiple database interactive system Mutually, it and is interpreted in multiple database interactive system and is examined in the gastric cancer genetic mutation and drug according to the search key Rope obtains gastric cancer genetic mutation and drug evidence.
Wherein, it includes gastric cancer genetic mutation Information Number that the gastric cancer genetic mutation and drug, which interpret multiple database interactive system, According to library, gastric cancer medicament treatment data library and gastric cancer documentation & info database；The gastric cancer genetic mutation information database is used for Store the relevant data of gastric cancer genetic mutation；Gastric cancer medicament treatment data library is for storing the treatment-related number of gastric cancer medicament According to；The gastric cancer documentation & info database is for storing the relevant data of gastric cancer document.
S303, the default correlation table of inquiry obtain the correlation of gastric cancer genetic mutation with drug evidence, by the correlation It is compared with clinical direct drug injection standard, obtains comparison result.
S304, according to the comparison result, execute corresponding operation.
Wherein, the default correlation table is the mapping for storing the correlation between gastric cancer genetic mutation and drug evidence Table.
The present embodiment is by establishing by gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer text The multiple database interactive system for offering information database composition interacts formula retrieval, and retrieving is simple, and can obtain more quasi- True and comprehensive search result.
Further, on the basis of above method embodiment, S304 is specifically included:
If the correlation is less than the clinical direct drug injection standard, trigger continuation search instruction, and according to it is described after Continuous search instruction is retrieved.
In another embodiment, S304 is specifically included:
If the correlation is more than or equal to the clinical direct drug injection standard, according to the gastric cancer genetic mutation and drug Evidence provides corresponding report.
Specifically, in more data exchange process, there are two types of processing modes:
The first data interactive processing method is that generality carries out wide in range property retrieval to all database, is obtained each The Evidence grade of database, feature are that time-consuming for interpretation process, interpret result broad covered area, the Evidence grade result of crawl is not Prominent, specifically include: Primary database, i.e. gastric cancer genetic mutation information database receive original as DIALOG information retrieval database DIALOG Search instruction 0, and initiate the request of searching database device；By coordinate indexing entry, in second databases and level Four data It is retrieved in library, obtains gastric cancer genetic mutation and drug evidence, result is directly fed back into report solution read apparatus, completes solution It reads.
The first more data interactive method based on wide in range retrieval specifically includes following steps, as shown in Figure 4:
S401, the retrieval request for receiving searching terminal, the retrieval request includes search key；
S402, it is handed over according to the retrieval request and gastric cancer genetic mutation and drug interpretation multiple database interactive system Mutually, and according to the search key in the gastric cancer genetic mutation and drug each database of multiple database interactive system is interpreted It is middle to carry out wide in range property retrieval, each database gastric cancer genetic mutation evidence relevant to drug etc. is obtained according to the result of retrieval Grade；
If S403, Evidence grade are greater than preset value, the database that Evidence grade is greater than preset value is determined as number of targets According to library, and the search result of target database is fed back into interpretation reporting device and is interpreted；
Wherein, it includes gastric cancer gene that the gastric cancer genetic mutation and drug, which interpret each database of multiple database interactive system, Make a variation information database, gastric cancer medicament treatment data library and gastric cancer documentation & info database；The gastric cancer genetic mutation information Database is for storing the relevant data of gastric cancer genetic mutation；It is controlled for storing gastric cancer medicament in gastric cancer medicament treatment data library Treat relevant data；The gastric cancer documentation & info database is for storing the relevant data of gastric cancer document.
The wide in range property retrieval refers to all data that multiple database interactive system is interpreted to gastric cancer genetic mutation and drug Library is retrieved, and each database does not set specific sorted order.
The purpose of wide in range property retrieval is in order to obtain all and gene and disease relevant information, so big without evidence value In the setting of preset value, wide in range property retrieval is defined as retrieving some genetic mutation all databases, obtains corresponding data The relevant evidence in library, and be compared according to the default grade form of correspondence database, it obtains all genetic mutation and drug and demonstrate,proves According to relationship, include it is high, medium and low on evidence after, search result is fed back to and interprets reporting device and interprets.
The present embodiment is by establishing by gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer text The multiple database interactive system for offering information database composition interacts formula retrieval, and retrieving is simple, and can obtain more quasi- True and comprehensive search result.
More data interactive methods of the above method based on wide in range retrieval can also include:
S404, the interpretation reporting device interpret the search result of target database, generate and interpret report.
S405, interpreting result statistic device, to count the gastric cancer genetic mutation retrieved in each target database relevant to drug The result of statistics is sent to the interpretation reporting device by the height of Evidence grade, and is received the interpretation reporting device and sent Interpretation report.
Second of data interactive processing method is, according to the data in gastric cancer genetic mutation and drug unscrambling data library device Evidence grade height in library successively carries out data interaction processing to drug gene variation correlation, and advantage is that can effectively shorten interpretation Process grabs most efficient evidence, improves the accuracy for interpreting result.
Successively exchange method specifically includes following steps to second of multiple database, as shown in Figure 5:
S501, the original search instruction for receiving searching terminal, the original search instruction includes search key；
S502, the progress of multiple database interactive system is interpreted according to the original search instruction and gastric cancer genetic mutation and drug It interacts, and interprets the gastric cancer base of multiple database interactive system in the gastric cancer genetic mutation and drug according to the search key Because being examined in the genetic mutation information database, gastric cancer information database and gastric cancer medicament database of variation information database Rope obtains list of medications；
S503, ratified according to the list of medications and the search key in the gastric cancer genetic mutation and drug therapy It is retrieved in information database, and presets correlation table according to the result queries of retrieval and obtain gastric cancer genetic mutation and drug card According to the first correlation；
If S504, first correlation are less than clinical direct drug injection standard, triggering first continues search instruction, and root Continue search instruction and the search key according to described first and interprets multiple database friendship in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer genetic mutation and drug therapy Consensus of experts information database of mutual system, and related according to described first Property and retrieval result queries preset correlation table obtain second correlation of the gastric cancer genetic mutation with drug evidence；
If S505, second correlation are less than clinical direct drug injection standard, triggering second continues search instruction, and root Continue search instruction and the search key according to described second and interprets multiple database friendship in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer genetic mutation and drug therapy clinical trials information database of mutual system, and related according to described second Property and retrieval result queries preset correlation table obtain third correlation of the gastric cancer genetic mutation with drug evidence；
If S506, the third correlation are less than the clinical direct drug injection standard, trigger third and continues search instruction, And search instruction and the search key are continued according to the third and interpret most evidences in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer documentation & info database of library interactive system, obtains final search result；
If S507, first correlation/second correlation/third correlation are more than or equal to clinical directly use Medicine standard then interprets gastric cancer genetic mutation and drug.
The present embodiment is by establishing by gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer text The multiple database interactive system for offering information database composition interacts formula retrieval, and retrieving is simple, and can obtain more quasi- True and comprehensive search result.
Wherein, S504 is specifically included:
If first correlation is less than clinical direct drug injection standard, triggering first continues search instruction, and according to institute It states the first continuation search instruction and the search key and interprets multiple database interaction system in the gastric cancer genetic mutation and drug It is retrieved in the gastric cancer genetic mutation of system and drug therapy Consensus of experts information database, obtains gastric cancer genetic mutation and drug Evidence feeds back to the genetic mutation and gastric cancer information database, by the genetic mutation and the comprehensive medicine of gastric cancer information database It is fed back to after the search result in object treatment data library and interprets result statistic device, and the result queries of the retrieval are default related Property table and with first correlation merge, obtain second correlation of the gastric cancer genetic mutation with drug evidence.
S506 is specifically included:
If the interpretation result statistic device judgement knows that the third correlation is less than the clinical direct drug injection standard, It then triggers third and continues search instruction to interpreting reporting device, and search instruction and retrieval key are continued according to the third Word in the gastric cancer and variation documentation & info database that the gastric cancer genetic mutation and drug interpret multiple database interactive system into Row retrieval, and the result queries of the retrieval are preset into correlation table and are merged with the third correlation, obtain gastric cancer gene The final search result of variation and drug evidence, and gastric cancer genetic mutation and drug are interpreted according to final search result.
Above-mentioned multiple database successively exchange method further include:
If S508, judgement know that the final search result is less than the clinical direct drug injection standard, feed back third after Continue search instruction to the gastric cancer genetic mutation information database.
In practical interactive process kind, Primary database, i.e. gastric cancer genetic mutation information database, as information retrieval data Library receives original search instruction 0, and initiates the request of searching database device；It is preferential in second level by coordinate indexing entry Database is retrieved in second level unscrambling data library, obtain gastric cancer genetic mutation and drug evidence, and feed back to first layer Result statistic device is interpreted in grade unscrambling data library and retrieval；Result statistic device is interpreted in retrieval, judges the gastric cancer base currently retrieved Because of the correlation to make a variation with drug evidence, if reaching medication clinical criteria, No. 1 interpretation report instruction is assigned to interpretation report dress It sets；If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, and sending continues retrieval and refers to Enable 1.
It interprets report instruction for No. 1 and refers to that interpretation reporting device can grab the gastric cancer genetic mutation currently retrieved and drug is demonstrate,proved It according to data, generates and interprets report, and terminate entire solution read procedure.
Continue search instruction 1 to refer to through DIALOG information retrieval database DIALOG, successively carry out the retrieval in third level unscrambling data library, And obtain the process of gastric cancer genetic mutation Yu drug evidence.
Processing continue search instruction 1 the following steps are included:
Primary database, i.e. gastric cancer genetic mutation information database, as DIALOG information retrieval database DIALOG, receiving continues retrieval and refers to It enables 1 and initiates to continue the request of searching database device.
It is preferential in second databases by coordinate indexing entry, i.e., it is retrieved, is obtained in third level unscrambling data library Gastric cancer genetic mutation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second After level interprets result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges that the first level of current composite and the gastric cancer gene of the second level retrieval become The different correlation with drug evidence assigns No. 2 interpretation report instructions to interpretation reporting device if reaching medication clinical criteria； If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, issues and continues search instruction 2。
It interprets report instruction for No. 2 and refers to that interpretation reporting device can grab the gastric cancer genetic mutation currently retrieved and drug is demonstrate,proved It according to data, generates and interprets report, and terminate entire solution read procedure.
Continue search instruction 2 to refer to through DIALOG information retrieval database DIALOG, successively carry out the retrieval in the 4th level unscrambling data library, And obtain the process of gastric cancer genetic mutation Yu drug evidence.
Processing continue search instruction 2 the following steps are included:
Primary database, i.e. gastric cancer genetic mutation information database, as DIALOG information retrieval database DIALOG, receiving continues retrieval and refers to It enables 2 and initiates to continue the request of searching database device.
It is preferential in second databases by coordinate indexing entry, i.e., it is retrieved, is obtained in fourth stage unscrambling data library Gastric cancer genetic mutation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second After level, third level interpret result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges the stomach that the first level of current composite, the second level, third level are retrieved The correlation that oncogene makes a variation with drug evidence assigns No. 3 interpretation report instruction to solutions and reads the newspaper if reaching medication clinical criteria Accuse device；If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, and sending continues to examine Suo Zhiling 3.
No. 3 interpretations report instruction is assigned to refer to, interpret reporting device can grab the gastric cancer genetic mutation that currently retrieves with Drug proof data generates and interprets report, and terminates entire solution read procedure.
The continuation search instruction 3 refers to, by DIALOG information retrieval database DIALOG, successively carries out layer 5 grade unscrambling data library Retrieval, and obtain the process of gastric cancer genetic mutation Yu drug evidence.
Processing continue search instruction 3 the following steps are included:
Primary database, i.e. gastric cancer genetic mutation information database, as DIALOG information retrieval database DIALOG, receiving continues retrieval and refers to It enables 3 and initiates to continue the request of searching database device；
It is preferential in level Four database by coordinate indexing entry, i.e., it is retrieved, is obtained in level V unscrambling data library Gastric cancer genetic mutation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second After level, third level are interpreted, the 4th level interprets result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges the gastric cancer genetic mutation and the correlation of drug evidence currently retrieved, if Reach medication clinical criteria, then assigns No. 4 interpretation report instructions；If not up to clinical direct drug injection standard, assigns No. 5 solutions and reads the newspaper Accuse instruction.
It interprets report instruction for No. 4 and refers to the gastric cancer genetic mutation and drug evidence number for interpreting that reporting device can be retrieved currently According to, it generates and interprets report, the entire solution read procedure of end.
It interprets report instruction for No. 5 and refers to the gastric cancer genetic mutation and drug evidence number for interpreting that reporting device can be retrieved currently According to, it generates and interprets report, the entire solution read procedure of end.
For example, for message processing module to search instruction 0, the search result of appearance is as follows:
For the search result of search instruction 0, Information Statistics module criterion is score value >=50 point, triggers No. 1 interpretation Report instruction, no person, which triggers, continues search instruction 1.
For message processing module to search instruction 1 is continued, the search result of appearance is as follows:
For the search result of search instruction 1, Information Statistics module criterion is score value >=50 point, triggers No. 2 interpretations Report instruction, no person, which triggers, continues search instruction 2.
For message processing module to search instruction 2 is continued, the search result of appearance is as follows:
For the search result of search instruction 2, Information Statistics module criterion is score value >=50 point, triggers No. 3 interpretations Report instruction, no person, which triggers, continues search instruction 3.
For message processing module to search instruction 3 is continued, the search result of appearance is as follows:
For the search result of search instruction 3, Information Statistics module criterion is score value >=50 point, triggers No. 4 interpretations Report instruction, no person touch No. 5 interpretation report instructions.
Wherein, the second level unscrambling data library-drug indication (CFDA) consistent with genetic mutation information is denoted as CS2；The Two level unscrambling data libraries-drug indication (other) consistent with genetic mutation information is denoted as OS2；Second level unscrambling data Library-drug indication and genetic mutation information inconsistent (CFDA) are denoted as CN2；Second level unscrambling data library-drug indication (other) consistent with genetic mutation information are denoted as ON2；Third level unscrambling data library-drug indication and genetic mutation information one (country) is caused to be denoted as CS3；Third level unscrambling data library-drug indication (other) consistent with genetic mutation information is denoted as OS3； Third level unscrambling data library-drug indication and genetic mutation information inconsistent (country) are denoted as CN3；Third level interprets number ON3 is denoted as according to library-drug indication (other) consistent with genetic mutation information.
Final score value evaluation is as follows:
Genetic mutation relevant to disease and drug unscrambling data library can be established using exchange method provided in this embodiment, Interpretation standard, process and the model established are interpreted for the genetic mutation and drug of disease；With the multiple database exchange method and System can quickly and accurately be interpreted each variation by different levels, and interpretation standard is harsh to have science, can Accurate treatment suitable for disease.
Through the above description of the embodiments, those skilled in the art can be understood that each embodiment can It realizes by means of software and necessary general hardware platform, naturally it is also possible to pass through hardware.Based on this understanding, on Stating technical solution, substantially the part that contributes to existing technology can be embodied in the form of software products in other words, should Computer software product may be stored in a computer readable storage medium, such as ROM/RAM, magnetic disk, CD, including several fingers It enables and using so that a computer equipment (can be personal computer, server or the network equipment etc.) executes each implementation Method described in certain parts of example or embodiment.
Application Example 1: relevant drug interpretation evidence is mutated to the amplification on HER2 gene and is retrieved
Search instruction 0 is VEGFR2+amplication, is input to information retrieval interface module, gastric cancer genetic mutation is basic Information database receives search instruction " VEGFR2+amplication ", and initiates the request of searching database.
By preferential in second level unscrambling data library (i.e. gastric cancer genetic mutation and drug therapy approval in-formation database) In retrieved, obtain disease gene variation it is as follows with drug evidence:
Due to drug Lei Molu monoclonal antibody, Ah pa is in the highest Evidence grade of highest drug and genetic mutation, information for Buddhist nun Statistical module triggers junior's instruction " No. 1 interpretation report instruction "；
The disease gene variation currently retrieved and drug proof data can be grabbed by interpreting reporting device, generated solution and read the newspaper It accuses, and terminates entire solution read procedure.
Application Example 2: relevant drug interpretation evidence is mutated to P.Tyr101Ter on BRCA1 gene and is retrieved
Search instruction 0 is BRCA1+Tyr101Ter, is input to information retrieval interface module, gastric cancer genetic mutation is believed substantially Breath database receives search instruction " BRCA1+Tyr101Ter ", and initiates the request of searching database.
By in preferential second level unscrambling data library (i.e. gastric cancer genetic mutation and drug therapy approval in-formation database) It is retrieved, it is as follows with drug evidence to obtain disease gene variation:
Search instruction 1, is input to information retrieval interface module, and the receiving of gastric cancer genetic mutation basic information database continues to examine Suo Zhiling 1, and initiate the request of searching database.
By preferential in third level unscrambling data library (i.e. gastric cancer genetic mutation and drug therapy Consensus of experts information data Library) in retrieved, obtain disease gene variation it is as follows with drug evidence:
Search instruction 2, is input to information retrieval interface module, and the receiving of gastric cancer genetic mutation basic information database continues to examine Suo Zhiling 2, and initiate the request of searching database.
By preferential in fourth stage unscrambling data library (i.e. gastric cancer genetic mutation and drug therapy clinical trials information data Library) in retrieved, obtain disease gene variation it is as follows with drug evidence:
Search instruction 3, is input to information retrieval interface module, and the receiving of gastric cancer genetic mutation basic information database continues to examine Suo Zhiling 3, and initiate the request of searching database.
It is retrieved in level V unscrambling data library (i.e. gastric cancer documentation & info database) by preferential, obtains disease Genetic mutation and drug evidence are as follows:
Information Statistics module BRCA1 gene mutation site Tyr101Ter, drug Evidence grade score value touch method 5 less than 50 points Number interpret report instruction；The head and neck neoplasm genetic mutation currently retrieved and drug evidence number can be grabbed by interpreting reporting device According to report is interpreted in generation, and terminates entirely to solve read procedure.
It is noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although reference Invention is explained in detail for previous embodiment, those skilled in the art should understand that: it still can be right Technical solution documented by foregoing embodiments is modified or equivalent replacement of some of the technical features；And this It modifies or replaces, the spirit and model of technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution It encloses.

Claims (7)

1. a kind of gastric cancer genetic mutation and drug interpret multiple database interactive system characterized by comprising gastric cancer genetic mutation Information database, gastric cancer medicament treatment data library and gastric cancer documentation & info database；
The gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and the gastric cancer documentation & info database It connects two-by-two respectively；
The gastric cancer genetic mutation information database is for storing the relevant data of gastric cancer genetic mutation；
Gastric cancer medicament treatment data library is for storing the treatment-related data of gastric cancer medicament；
The gastric cancer documentation & info database is for storing the relevant data of gastric cancer document；
Wherein, gastric cancer medicament treatment data library includes: gastric cancer genetic mutation and drug therapy approval in-formation database, gastric cancer Genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug therapy clinical trials Information Number According to library；
The original search instruction of searching terminal is received, the original search instruction includes search key；
It interprets multiple database interactive system with gastric cancer genetic mutation and drug according to the original search instruction to interact, and root The gastric cancer genetic mutation letter of multiple database interactive system is interpreted in the gastric cancer genetic mutation and drug according to the search key It ceases and is retrieved in the genetic mutation information database, gastric cancer information database and gastric cancer medicament database of database, obtain medicine Object inventory；
According to the list of medications and the search key in the gastric cancer genetic mutation and drug therapy approval in-formation data It is retrieved in library, and presets correlation table according to the result queries of retrieval and obtain the first of gastric cancer genetic mutation and drug evidence Correlation；
If first correlation is less than clinical direct drug injection standard, triggering first continues search instruction, and according to described the One, which continues search instruction and the search key, interprets multiple database interactive system in the gastric cancer genetic mutation and drug It is retrieved in gastric cancer genetic mutation and drug therapy Consensus of experts information database, and the result queries of the retrieval is preset Correlation table simultaneously merges with first correlation, obtains second correlation of the gastric cancer genetic mutation with drug evidence；
If second correlation is less than clinical direct drug injection standard, triggering second continues search instruction, and according to described the Two, which continue search instruction and the search key, interprets multiple database interactive system in the gastric cancer genetic mutation and drug It is retrieved in gastric cancer genetic mutation and drug therapy clinical trials information database, and the result queries of the retrieval is preset Correlation table simultaneously merges with second correlation, obtains third correlation of the gastric cancer genetic mutation with drug evidence；
If the third correlation is less than the clinical direct drug injection standard, triggers third and continue search instruction, and according to institute It states third and continues search instruction and the search key in the gastric cancer genetic mutation and drug interpretation multiple database interaction system It is retrieved in the gastric cancer documentation & info database of system, and the result queries of the retrieval is preset into correlation table and with described the Three correlations merge, and obtain the final search result of gastric cancer genetic mutation Yu drug evidence, and according to final search result to stomach Oncogene variation and drug are interpreted；
Wherein, when any one of first correlation, the second correlation, third correlation are greater than or equal to clinical direct drug injection When standard, then search program is terminated, and interpret to gastric cancer genetic mutation and drug.
2. system according to claim 1, which is characterized in that the system also includes: interpret reporting device；
The interpretation reporting device respectively with the gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and The gastric cancer documentation & info database connection generates for interpreting to received judging result and interprets report.
3. system according to claim 2, which is characterized in that the system also includes: result statistic device is interpreted in retrieval；
The interpretation result statistic device respectively with the gastric cancer genetic mutation information database, gastric cancer medicament treatment data library, Gastric cancer documentation & info database is connected with reporting device is interpreted, and counts the gastric cancer genetic mutation and drug phase retrieved in each database The Evidence grade of pass, judges that the height of the Evidence grade obtains judging result, and the judging result is sent to the interpretation Reporting device, and receive the interpretation report of the interpretation reporting device feedback.
4. system according to claim 1, which is characterized in that the gastric cancer genetic mutation information database includes that gene becomes Different information database, gastric cancer information database and gastric cancer medicament database；
The genetic mutation information database is selected from the group below one or more for storing: Gene Name, gene function background Introduction, chromosome location, transcript number, genetic mutation RS, signal path locating for gene, genetic mutation nucleotide diversity letter Breath, genetic mutation amino acid variation information, sequence variations are in nucleotide and amino acid levels function prediction result；
The gastric cancer information database is selected from the group below one or more for storing: disease happening part, disease name, generation Reason, genius morbi, diagnostics method and index；
The gastric cancer medicament database is selected from the group below one or more for storing: disease therapeuticing medicine, including chemicals, Target therapeutic agent, immunotherapy medicaments, gene therapy medicament.
5. system according to claim 1, which is characterized in that the gastric cancer genetic mutation and drug therapy approval in-formation number It is selected from the group below one or more for storing according to library: Trade-name of drug, adopted name, indication information, application method, agent Amount and management, contraindication, warning and/or precautionary measures, adverse reaction data, drug interaction and specific use crowd believe Breath；
The gastric cancer genetic mutation and the information retrieval level of drug therapy approval in-formation database include two layers, and first layer is stomach Cancer and genetic mutation information, the second layer are genetic mutation information；
The gastric cancer genetic mutation and drug therapy Consensus of experts information database are used to store and genetic mutation drug uses Diagnosis, treatment, monitoring and/or prognosis information；
The gastric cancer genetic mutation and the information retrieval level of drug therapy Consensus of experts information database include two layers, first layer For gastric cancer and genetic mutation information, the second layer is genetic mutation information；
The gastric cancer genetic mutation and drug therapy clinical trials information database for store completed clinical test and The clinical trial information of recruitment, including selected from the group below one or more: clinical research number, research title, research approach, variation Detection method, sample size, crowd characteristic, result of study and research conclusion；
The gastric cancer genetic mutation and the information retrieval level of drug therapy clinical trials information database include two layers, first layer For gastric cancer and genetic mutation information, the second layer is genetic mutation information.
6. system according to claim 1, which is characterized in that the gastric cancer documentation & info database is selected from down for storing That organizes is one or more: periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, research As a result, research conclusion, identification number PMID and the periodical IF factor；
The information retrieval level of the gastric cancer documentation & info database includes two layers, and first layer is gastric cancer and genetic mutation information, The second layer is genetic mutation information.
7. a kind of sizing screening method of gastric cancer genetic mutation and drug-associated comprising following steps:
(1) gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and gastric cancer documentation & info database are established；Its In
The gastric cancer genetic mutation information database, gastric cancer medicament treatment data library and the gastric cancer documentation & info database It connects two-by-two respectively；The gastric cancer genetic mutation information database is for storing the relevant data of gastric cancer genetic mutation；The stomach Cancer drug treatment data library is for storing the treatment-related data of gastric cancer medicament；The gastric cancer documentation & info database is for storing The relevant data of gastric cancer document；And wherein, gastric cancer medicament treatment data library includes: gastric cancer genetic mutation and drug therapy batch Calibration information database, gastric cancer genetic mutation and drug therapy Consensus of experts information database and gastric cancer genetic mutation and drug are controlled Treat clinical trial information's database；
(2) obtaining disease and/or genetic mutation in gastric cancer genetic mutation information database is search key, is controlled in gastric cancer medicament It treats and is retrieved in database and gastric cancer documentation & info database, obtain gastric cancer genetic mutation and drug relationship evidence, it is described Evidence is separately stored in corresponding database；
(3) it is scored based on the gastric cancer genetic mutation with drug relationship evidence；
(4) the being associated property of drug that the genetic mutation related disease is applicable in is classified according to the overall score of each scoring；
The original search instruction of searching terminal is received, the original search instruction includes search key；
It interprets multiple database interactive system with gastric cancer genetic mutation and drug according to the original search instruction to interact, and root The gastric cancer genetic mutation letter of multiple database interactive system is interpreted in the gastric cancer genetic mutation and drug according to the search key It ceases and is retrieved in the genetic mutation information database, gastric cancer information database and gastric cancer medicament database of database, obtain medicine Object inventory；
According to the list of medications and the search key in the gastric cancer genetic mutation and drug therapy approval in-formation data It is retrieved in library, and presets correlation table according to the result queries of retrieval and obtain the first of gastric cancer genetic mutation and drug evidence Correlation；
If first correlation is less than clinical direct drug injection standard, triggering first continues search instruction, and according to described the One, which continues search instruction and the search key, interprets multiple database interactive system in the gastric cancer genetic mutation and drug It is retrieved in gastric cancer genetic mutation and drug therapy Consensus of experts information database, and the result queries of the retrieval is preset Correlation table simultaneously merges with first correlation, obtains second correlation of the gastric cancer genetic mutation with drug evidence；
If second correlation is less than clinical direct drug injection standard, triggering second continues search instruction, and according to described the Two, which continue search instruction and the search key, interprets multiple database interactive system in the gastric cancer genetic mutation and drug It is retrieved in gastric cancer genetic mutation and drug therapy clinical trials information database, and the result queries of the retrieval is preset Correlation table simultaneously merges with second correlation, obtains third correlation of the gastric cancer genetic mutation with drug evidence；
If the third correlation is less than the clinical direct drug injection standard, triggers third and continue search instruction, and according to institute It states third and continues search instruction and the search key in the gastric cancer genetic mutation and drug interpretation multiple database interaction system It is retrieved in the gastric cancer documentation & info database of system, and the result queries of the retrieval is preset into correlation table and with described the Three correlations merge, and obtain the final search result of gastric cancer genetic mutation Yu drug evidence, and according to final search result to stomach Oncogene variation and drug are interpreted；
Wherein, when any one of first correlation, the second correlation, third correlation are greater than or equal to clinical direct drug injection When standard, then search program is terminated, and interpret to gastric cancer genetic mutation and drug.
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