CN109045076A - A kind of preparation method of ginkgo biloba p.e - Google Patents
A kind of preparation method of ginkgo biloba p.e Download PDFInfo
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- CN109045076A CN109045076A CN201811244694.8A CN201811244694A CN109045076A CN 109045076 A CN109045076 A CN 109045076A CN 201811244694 A CN201811244694 A CN 201811244694A CN 109045076 A CN109045076 A CN 109045076A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation methods of ginkgo biloba p.e, wherein the following steps are included: (1) providing raw material: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnate 10 hours, solution temperature controls between 50 degree ~ 55；(2) extract solution: twice, combined extract is simultaneously concentrated into density as 1.1-1.2 to refluxing extraction, and ginkgo leaf is filtered out, solution is stayed；By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes, collect solution；(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.The present invention can greatly save time cost, and extraction effect is more preferable, have extraordinary economic value and industrial value.
Description
Technical field
The present invention relates to a kind of preparation methods of ginkgo biloba p.e.
Background technique
The cumbersome and extraction effect of the step of ginkgo is extracted in the prior art is undesirable.
Summary of the invention
In view of this, being mentioned the technical problems to be solved by the present invention are: providing the ginkgo leaf that one kind is simple, extraction effect is good
Take the preparation method of object.
In order to achieve the above object, the present invention adopts the following technical scheme that realize:
A kind of preparation method of ginkgo biloba p.e, wherein the following steps are included:
(1) raw material are provided: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnates 8-10 hours, solution
Temperature controls between 50 degree~55；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes,
Collect solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
Preferably, including following specific process step:
Step (1) before, further include sorting step, select the ginkgo leaf that turns yellow completely, clean, drying；
Preferably, including following specific process step:
It in the drying steps, is completed in vacuum pump, it is 66 degree that temperature in tank, which is arranged, vacuum degree 0.10Mpa；?
It to dry ginkgo biloba p.e, is then crushed, is sieved with 100 mesh sieve, obtain ginkgo biloba p.e dry powder.
Preferably, including following specific process step:
The step (1) and step (2) between further include refluxing extraction twice, combined extract simultaneously be concentrated into density be 1.1-
1.2。
As shown from the above technical solution, the beneficial effects of the present invention are:
Compared with prior art, the present invention can greatly save time cost, and extraction effect is more by the above method
It is good, there is extraordinary economic value and industrial value.
Specific embodiment
In order to enable those skilled in the art to be further understood that feature and technology contents of the invention, please referring to following has
Close detailed description of the invention.
Embodiment 1:
A kind of preparation method of ginkgo biloba p.e, wherein the following steps are included:
(1) raw material are provided: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnates 10 hours, solution temperature
Degree control is at 50 degree；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes,
Collect solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
It can effectively extract through the above way, step is simple, and effect is good.
Embodiment 2:
A kind of preparation method of ginkgo biloba p.e, wherein the following steps are included:
(1) raw material are provided: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnates 9 hours, solution temperature
Degree control is at 53 degree；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes,
Collect solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
It can effectively extract through the above way, step is simple, and effect is good.
Embodiment 3:
A kind of preparation method of ginkgo biloba p.e, wherein the following steps are included:
(1) raw material are provided: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnates 8 hours, solution temperature
Degree control is at 55 degree；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes,
Collect solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
It can effectively extract through the above way, step is simple, and effect is good.
Embodiment 4:
A kind of preparation method of ginkgo biloba p.e, wherein the following steps are included:
(1) provide raw material: the ginkgo leaf that choosing turns yellow completely is cleaned, drying.It is in vacuum pump in the drying steps
It completes, it is 66 degree that temperature in tank, which is arranged, vacuum degree 0.10Mpa；Dry ginkgo biloba p.e is obtained, is then crushed,
It sieves with 100 mesh sieve, obtains ginkgo biloba p.e dry powder.The step (1) and step (2) between can also include refluxing extraction twice,
Combined extract is simultaneously concentrated into density as 1.1-1.2；
55 parts of ginkgo leaf are taken according to parts by weight, places into ethanol solution and impregnates 10 hours, solution temperature is controlled at 55 degree；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat later to boiling, and continue 30 minutes,
Collect solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
But the foregoing is merely preferable possible embodiments of the invention, not to limit to the scope of the patents of the invention, therefore
It is all to change with equivalent structure made by present specification, similarly within the scope of the present invention.
Claims (4)
1. a kind of preparation method of ginkgo biloba p.e, which comprises the following steps:
(1) raw material are provided: taking 55 parts of ginkgo leaf according to parts by weight, places into ethanol solution and impregnates 8-10 hours, solution temperature
Control is between 50 degree ~ 55；
(2) extract solution: the ginkgo leaf in step (1) being filtered out, solution is stayed；
By solution -5 degree at a temperature of carry out freezing 5 hours, directly heat to boiling, and continue 30 minutes, collect later
Solution；
(4) it is concentrated: by solution 6 hours, separates supernatant, obtain water supernatant liquid, remove sediment；
(5) depickling: water supernatant liquid is subjected to depickling processing, collects depickling liquid；
(6) dry: depickling liquid is dried, crush, obtain ginkgo leaf extract powder.
2. the preparation method of ginkgo biloba p.e according to claim 1, which is characterized in that walked including following concrete technology
It is rapid:
Step (1) before, further include sorting step, select the ginkgo leaf that turns yellow completely, clean, drying.
3. the preparation method of ginkgo biloba p.e according to claim 1, which is characterized in that walked including following concrete technology
It is rapid:
It in the drying steps, is completed in vacuum pump, it is 66 degree that temperature in tank, which is arranged, and vacuum degree is 0 .10Mpa；It obtains
Dry ginkgo biloba p.e, is then crushed, and is sieved with 100 mesh sieve, and ginkgo biloba p.e dry powder is obtained.
4. the preparation method of ginkgo biloba p.e according to claim 1, which is characterized in that walked including following concrete technology
It is rapid:
The step (1) and step (2) between further include refluxing extraction twice, combined extract simultaneously be concentrated into density be 1 .1-1
.2。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811244694.8A CN109045076A (en) | 2018-10-24 | 2018-10-24 | A kind of preparation method of ginkgo biloba p.e |
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| CN201811244694.8A CN109045076A (en) | 2018-10-24 | 2018-10-24 | A kind of preparation method of ginkgo biloba p.e |
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| Publication Number | Publication Date |
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| CN109045076A true CN109045076A (en) | 2018-12-21 |
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| CN201811244694.8A Pending CN109045076A (en) | 2018-10-24 | 2018-10-24 | A kind of preparation method of ginkgo biloba p.e |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154492A (en) * | 2022-08-24 | 2022-10-11 | 江苏贝斯康药业有限公司 | Preparation method of ginkgo leaf extract |
-
2018
- 2018-10-24 CN CN201811244694.8A patent/CN109045076A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154492A (en) * | 2022-08-24 | 2022-10-11 | 江苏贝斯康药业有限公司 | Preparation method of ginkgo leaf extract |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181221 |
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| WD01 | Invention patent application deemed withdrawn after publication |