CN109044411A - Tear based on capillary power drive detects contact lense - Google Patents
Tear based on capillary power drive detects contact lense Download PDFInfo
- Publication number
- CN109044411A CN109044411A CN201811038240.5A CN201811038240A CN109044411A CN 109044411 A CN109044411 A CN 109044411A CN 201811038240 A CN201811038240 A CN 201811038240A CN 109044411 A CN109044411 A CN 109044411A
- Authority
- CN
- China
- Prior art keywords
- tear
- runner
- cavity
- section
- contact lense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0067—Tear or lachrymal fluid
Abstract
A kind of tear detection contact lense based on capillary power drive, including with the internal layer of Corneal Contact and the outer layer contacted with eyelid, be provided on the internal layer for tear component detection runner and for by tear discharge runner cavity, the runner includes that tear entrance and tear export, the runner is using capillarity from driving tear from the tear entrance to the tear output flow, the cavity is connected with the runner in the tear exit and forms an angle with the runner, chamber film corresponding with the cavity is provided on the outer layer, the chamber film and the cavity groups are at chamber, it is acted using the blink of wearer, squeeze the chamber film, the volume of the chamber is set to change, generate pressure, runner is discharged in the tear that the tear is exported.The contact lense flows into runner from driving tear by capillary force, and chromogenic reaction can occur with substance that show color in runner, realizes the detection of special component in tear, can be used for the diagnosis of related disease.
Description
Technical field
The present invention relates to a kind of, and the tear based on capillary power drive detects contact lense.
Background technique
Contain Multiple components in human body tear, some diseases will affect tear component concentration and change, research
Show through the reliable analysis to tear component, advantageous foundation can be provided for the diagnosis of related disease.Tear component is examined at present
Surveying widespread practice is to collect tear by device outside, then carries out coherent detection, there are step complexity, inspections for present mode
Survey the disadvantages of sensitivity is not high.
Summary of the invention
It is a primary object of the present invention to overcome the prior art, a kind of tear inspection based on capillary power drive is provided
Survey contact lense.
To achieve the above object, the invention adopts the following technical scheme:
A kind of tear detection contact lense based on capillary power drive, including being contacted with the internal layer of Corneal Contact and with eyelid
Outer layer, be provided on the internal layer for the runner of tear component detection and for by the cavity of tear discharge runner, institute
Stating runner includes that tear entrance and tear export, and the runner is using capillarity from driving tear from the tear entrance to institute
Tear output flow is stated, the cavity is connected with the runner in the tear exit and forms an angle with the runner,
Chamber film corresponding with the cavity is provided on the outer layer, the chamber film and the cavity groups utilize wearer's at chamber
Blink movement, squeezes the chamber film, the volume of the chamber is made to change, and generates pressure, the tear that the tear is exported
Runner is discharged.
One or more substance that show colors are also embedded in the runner, when tear flows in the runner, in tear
Specific chromogenic reaction occurs for special component and substance that show color, dense to detect the ingredient in tear with the depth using reaction color
The height of degree.
The internal layer is identical as the shape of the outer layer and radian is matched with eye shape.
The runner includes that the tear entrance of multiple parallel connections and a tear export.
The runner includes the main body runner that section is square, and be square in the runner there are one section of section
The sectional dimension of small flow channels, the small flow channels is less than the main body runner, for preventing tear from exporting from the tear to described
Tear entrance reverse flow, it is preferable that the small flow channels are arranged close to the tear exit in the cavity and the runner
Tie point rear.
The side length in the section of the main body runner is 0.3mm, and the side length in the section of the small flow channels is 0.2mm.
The cavity is connected by the microchannel of one section of descending variation in section with the runner.
There are change of gradients for the size in the section, it is preferable that the microchannel includes with the runner in the first angle
The first bench and with the runner be in the second angle the second step, first angle is greater than second angle, and institute
The change of gradient for stating the second step is more anxious than the change of gradient of first bench.
The internal layer includes multiple micro-structures, and the micro-structure is circumferentially equally spaced on the inner layer, each micro- knot
It is configured to the runner and the cavity, the outer layer includes multiple chamber films, the institute on the multiple chamber film and each micro-structure
State cavity one-to-one correspondence.
Be equally spaced 3 micro-structures on the inner layer.
The invention has the following beneficial effects:
The present invention provides a kind of, and the tear based on capillary power drive detects contact lense, in the feelings of no any power of implantation
Under condition, tear flows in runner under the driving of capillary force.In tear exit, is acted, squeezed using the blink of wearer
Chamber film, makes chamber volume change, and generates pressure, and runner is discharged in the tear of tear outlet.The tear detect contact lense with
Simple and effective mode realizes the collection of tear.
In preferred embodiment, specific substance that show color is also embedded in runner, when tear flows in runner, with colour developing object
Special chromogenic reaction, the height of the depth reflection tear specific component concentration of color, by tear special component occur for matter
The diagnosis for being detected as related disease foundation is provided, and detection sensitivity is high, implements simple.
The contact lense of the preferred embodiment of the present invention by capillary force from driving tear flow into runner, and in runner with insertion
Chromogenic reaction occurs for substance, realizes the detection of special component in tear, can be effectively used for the diagnosis of related disease, which is
The detection of tear component provides a kind of simple and convenient effective solution scheme.
Detailed description of the invention
Fig. 1 is that the tear of an embodiment of the present invention detects contact lense structural schematic diagram.
Fig. 2 is a kind of contact lense endothecium structure figure of embodiment.
Fig. 3 is a kind of contact lense layer structure figure of embodiment.
Fig. 4 is tear outlet and cavity structure enlarged drawing in a kind of contact lense of embodiment.
Appended drawing reference in figure:
10- internal layer, 11- tear entrance, 12- runner, 13- cavity, the outlet of 14- tear, 20- outer layer, 21- chamber film
Specific embodiment
It elaborates below to embodiments of the present invention.It is emphasized that following the description is only exemplary,
The range and its application being not intended to be limiting of the invention.
Refering to fig. 1 to Fig. 4, in one embodiment, a kind of tear based on capillary power drive detects contact lense, including with
It is provided on the outer layer 20 with the internal layer 10 of Corneal Contact and for being contacted with eyelid, the internal layer 10 for tear component
The runner 12 of detection and for by the cavity 13 of tear discharge runner 12, the runner 12 to include that tear entrance 11 and tear go out
Mouth 14, the runner 12 export 14 flowings, institute from the tear entrance 11 to the tear from driving tear using capillarity
It states cavity 13 to be connected at tear outlet 14 with the runner 12 and form an angle with the runner 12, the outer layer 20
On be provided with chamber film 21 corresponding with the cavity 13, the chamber film 21 forms chamber with the cavity 13, utilizes wearer's
Blink movement, squeezes the chamber film 21, the volume of the chamber is made to change, and generates pressure, the tear that the tear is exported
Runner 12 is discharged in liquid.
In a preferred embodiment, microchannel and the runner of the cavity 13 by one section of descending variation in section
12 are connected.
In a more preferred embodiment, there are change of gradients for the size in the section.In the especially preferred embodiments, institute
Stating microchannel includes the second ladder with the runner 12 in the first bench of the first angle and with the runner 12 in the second angle
Section, first angle is greater than second angle, and the change of gradient of the second step is than the gradient of first bench
Change more anxious.In preferred embodiment as shown in Figure 4, the projection of shape of first bench is parallelogram, described the
The projection of shape of two bench is trapezoidal.
In a preferred embodiment, the main body runner 12 that the runner 12 is square including section, and the runner 12
The sectional dimension of the middle small flow channels 12 being square there are one section of section, the small flow channels 12 is less than the main body runner 12, uses
To prevent tear from tear outlet 14 to 11 reverse flow of tear entrance, it is preferable that the small flow channels 12 are close to institute
State the rear that the cavity 13 and the tie point of the runner 12 are set at tear outlet 14.
In a more preferred embodiment, the side length in the section of the main body runner 12 is 0.3mm, and the small flow channels 12 are cut
The side length in face is 0.2mm.
In a preferred embodiment, the internal layer 10 is identical as the shape of the outer layer 20 and radian and eye shape
Match.
In a preferred embodiment, the runner 12 includes that the tear entrance 11 of multiple parallel connections and a tear export 14.
In a preferred embodiment, the internal layer 10 includes multiple micro-structures, micro-structure edge on the internal layer 10
Circumference is equally spaced, and each micro-structure is formed with the runner 12 and the cavity 13, and the outer layer 20 includes multiple chamber films 21,
The multiple chamber film 21 is corresponded with the cavity 13 in each micro-structure.
In a preferred embodiment, be equally spaced 3 micro-structures on the internal layer 10.
In a preferred embodiment, one or more substance that show colors are also embedded in the runner 12, when tear is in the stream
In road 12 when flowing, specific chromogenic reaction occurs for special component and substance that show color in tear, to utilize the depth of reaction color
The shallow height to detect the constituent concentration in tear.
The feature and working method of the embodiment of the present invention are further described below in conjunction with attached drawing.
Refering to fig. 1 to Fig. 4, which is made of internal layer 10 and outer layer 20, and internal layer 10 is clear by plasma with outer layer 20
Washing machine handles 30s, then bonds together to form one.Above-mentioned internal layer 10 has the runner 12 and cavity 13 for detecting tear component,
Above-mentioned outer layer 20 has the chamber film 21 of protrusion.
Above-mentioned runner 12 includes two tear entrances 11 in parallel and a tear outlet 14, driving of the tear in capillary force
Under from any tear entrance 11 enter runner 12, and be transported to tear outlet 14, due to the presence of surface tension of liquid, tear
Rest on tear outlet 14, and stop motion.In this process, flowing of the tear in runner 12 fully relies on the drive of capillary force
It is dynamic, without providing additional power source.
Above-mentioned cavity 13 forms chamber with above-mentioned chamber film 21, during wearer blinks, extrusion chamber film 21, and chamber inner body
Product changes, and generates pressure, will stay on the tear discharge runner 12 of tear outlet 14.
Above-mentioned runner 12 is embedded in the predetermined substance for colour developing, when tear flows in runner 12, in tear
Specific chromogenic reaction occurs for special component and substance that show color, and the depth of reaction color shows the height of the constituent concentration in tear
It is low.
The narrow runner for the square that above-mentioned runner 12 is side length 0.2mm there are one section of section, not due to sectional dimension
Together, lead to the different resistance in both ends, to be used to the reverse flow for preventing tear in tear outlet 14.
Above-mentioned cavity 13 is in parallel with runner 12 by the microchannel of one section of descending variation of section gradient and at a clamp
Angle, ensure that the capillary force in runner 12 not will receive the influence of cavity 13, and tear is successfully exported 14 by the pressure energy of cavity 13
Tear discharge.
As shown in Figure 1, the multizone tear detection contact lense based on capillary power drive is made of internal layer 10 and outer layer 20, it is interior
Layer 10 is contacted with cornea, and tear enters by capillary force from tear entrance 11, and under the driving of capillary force, tear is in runner 12
Middle flowing, and chromogenic reaction occurs with the substance that show color being embedded in runner 12, the depth of color characterizes tear specific component concentration
Height, finally, tear is under the pressure of cavity 13, from 14 outflow of tear outlet.Outer layer 20 is provided with chamber film 21, chamber film 21 with
Cavity 13 corresponds, and forms chamber together.
Fig. 2 illustrates that the specific micro-structure of internal layer 10, micro-structure are circumferentially equally spaced 3, and multizone may be implemented not
Congruent detection.Micro-structure includes tear entrance 11, runner 12, tear outlet 14 and cavity 13.These structures pass through string
It is connected in parallel, the system for forming an opening, tear is in system internal circulation flow.
Fig. 3 indicates the specific structure of outer layer 20, the chamber film 21 including 3 with the one-to-one protrusion of cavity 13.Protrusion
Chamber film 21 and cavity 13 form chamber, transfer pressure.
Fig. 4 indicates the schematic enlarged-scale view of tear outlet 14 and cavity 13.Cavity 13 is descending by one section of section gradient
The microchannel of variation is in parallel with runner 12 and forms an angle.In runner 12 there are one section of sectional dimension reduce narrow runner,
By the variation of sectional dimension, for preventing tear in the reverse flow of tear outlet 14.
The above content is combine it is specific/further detailed description of the invention for preferred embodiment, cannot recognize
Fixed specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs,
Without departing from the inventive concept of the premise, some replacements or modifications can also be made to the embodiment that these have been described,
And these substitutions or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (10)
1. a kind of tear based on capillary power drive detects contact lense, which is characterized in that including with Corneal Contact internal layer and
The outer layer contacted with eyelid is provided on the internal layer for the runner of tear component detection and for runner to be discharged in tear
Cavity, the runner includes that tear entrance and tear export, and the runner is using capillarity from driving tear from the tear
Liquid entrance to the tear output flow, the cavity the tear exit be connected with the runner and with the runner at
Certain angle is provided with chamber film corresponding with the cavity, the chamber film and the cavity groups on the outer layer into chamber, utilizes
The blink of wearer acts, and squeezes the chamber film, the volume of the chamber is made to change, and generates pressure, the tear is gone out
Runner is discharged in the tear of mouth.
2. tear as described in claim 1 detects contact lense, which is characterized in that also embedded with one or more aobvious in the runner
Color substance, when tear flows in the runner, specific chromogenic reaction occurs for special component and substance that show color in tear,
The height of the constituent concentration in tear is detected with the depth using reaction color.
3. contact lense as claimed in claim 1 or 2, which is characterized in that the internal layer is identical as the shape of the outer layer and arc
Degree is matched with eye shape.
4. contact lense as described in any one of claims 1 to 3, which is characterized in that the runner includes the tear of multiple parallel connections
Entrance and a tear outlet.
5. such as the described in any item contact lenses of Claims 1-4, which is characterized in that the runner includes what section was square
Main body runner, and there are the small flow channels that one section of section is square in the runner, the sectional dimension of the small flow channels is less than institute
Main body runner is stated, for preventing tear from exporting from the tear to the tear entrance reverse flow, it is preferable that the small flow channels
The rear of the tie point of the cavity and the runner is set close to the tear exit.
6. contact lense as claimed in claim 5, which is characterized in that the side length in the section of the main body runner is 0.3mm, described
The side length in the section of small flow channels is 0.2mm.
7. such as contact lense as claimed in any one of claims 1 to 6, which is characterized in that the cavity by one section of section by greatly to
The microchannel of small variation is connected with the runner.
8. contact lense as claimed in claim 7, which is characterized in that there are change of gradients for the size in the section, it is preferable that institute
Stating microchannel includes the second step with the runner in the first bench of the first angle and with the runner in the second angle, institute
The first angle is stated greater than second angle, and the change of gradient of the second step than first bench change of gradient more
It is anxious.
9. contact lense as claimed in any one of claims 1 to 8, which is characterized in that the internal layer includes multiple micro-structures, described
Micro-structure is circumferentially equally spaced on the inner layer, and each micro-structure is formed with the runner and the cavity, the outer layer
Including multiple chamber films, the cavity on the multiple chamber film and each micro-structure is corresponded.
10. contact lense as claimed in claim 9, which is characterized in that be equally spaced 3 micro-structures on the inner layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811038240.5A CN109044411B (en) | 2018-09-06 | 2018-09-06 | Tear detection contact lens based on capillary force driving |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811038240.5A CN109044411B (en) | 2018-09-06 | 2018-09-06 | Tear detection contact lens based on capillary force driving |
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| Publication Number | Publication Date |
|---|---|
| CN109044411A true CN109044411A (en) | 2018-12-21 |
| CN109044411B CN109044411B (en) | 2021-04-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811038240.5A Active CN109044411B (en) | 2018-09-06 | 2018-09-06 | Tear detection contact lens based on capillary force driving |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111631754A (en) * | 2020-05-26 | 2020-09-08 | 清华大学 | Automatic sampling system of pharynx swab |
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| CN111631754B (en) * | 2020-05-26 | 2021-07-09 | 清华大学 | Automatic sampling system of pharynx swab |
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| Publication number | Publication date |
|---|---|
| CN109044411B (en) | 2021-04-23 |
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