CN109044328A - Alimentary canal electro physiology visualization device - Google Patents

Alimentary canal electro physiology visualization device Download PDF

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Publication number
CN109044328A
CN109044328A CN201810979308.3A CN201810979308A CN109044328A CN 109044328 A CN109044328 A CN 109044328A CN 201810979308 A CN201810979308 A CN 201810979308A CN 109044328 A CN109044328 A CN 109044328A
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CN
China
Prior art keywords
alimentary canal
flexible displays
multichannel
processing unit
sacculus
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201810979308.3A
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Chinese (zh)
Inventor
徐英舜
俞清翔
陈鑫
王晓雨
朱兰平
王邦茂
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Tianjin Medical University
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Tianjin Medical University
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Application filed by Tianjin Medical University filed Critical Tianjin Medical University
Priority to CN201810979308.3A priority Critical patent/CN109044328A/en
Publication of CN109044328A publication Critical patent/CN109044328A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/273Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/725Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/742Details of notification to user or communication with user or patient ; user input means using visual displays

Abstract

A kind of equipment can be used for alimentary canal electricity physiological signal acquisition process display one, especially with sacculus flexible displays made of flexible display material, it can realize that different colours or gray scale are shown in the different zones of display, to which home position manifestation electricity physiological signal is movable strong and weak directly in alimentary canal and is distributed, it includes multi-channel electrode device, multichannel amplification and processing unit, sacculus flexible displays, external treatment and display unit and power supply, the equipment have great importance for the research of Gastroenterology with clinical application.

Description

Alimentary canal electro physiology visualization device
Technical field
It can be used for the integrated equipment of alimentary canal electricity physiological signal acquisition process display the present invention relates to a kind of, especially with Sacculus flexible displays made of flexible display material can realize that different colours or gray scale are aobvious in the different zones of display Show, so that home position manifestation electricity physiological signal is movable strong and weak directly in alimentary canal and is distributed.Wherein multi-channel electrode device is used In the acquisition for realizing alimentary canal electricity physiological signal, multichannel amplification and processing unit adopting for realizing alimentary canal electricity physiological signal Collection and in real time processing, and alimentary canal electricity physiological signal is converted into corresponding region different colours or gray scale on sacculus flexible displays Display.
Background technique
The present invention relates to the acquisition of alimentary canal electricity physiological signal, processing and display.The research of alimentary canal electricity physiological signal and Using at present with stomach electricity based on, intestines electricity be more difficult analyze and summarize, pertinent literature report seldom, this sentence stomach electricity based on be situated between It continues.
Gastric electrical activity is the most basic physiological activity of stomach, controls the movement of stomach.Cajal between longitudinal muscle and circular muscle Interstitial cell (Interstitial Cells of Cajal, ICC) is pacemaker and the conduction person of stomach and intestine slow-wave activity, slow wave Frequency, the rhythm and pace of moving things and the direction of propagation of stomach contraction are controlled, frequency and amplitude provide the important information shunk about stomach, section Rule is abnormal to will lead to stomach function and dyskinesia.
Gastric electrical activity can be detected in serous coat, intracavitary, body surface, there is no a kind of optimal measuring method at present.Serous coat It is most reliable for recording gastric electrical activity, but this method is invasive;Intracavitary record is that measuring electrode is placed in mucous membrane in stomach Surface, this measurement method is substantially noninvasive, and electrode and gastric mucosa directly contact, thus by other physiological signals Fewer with the interference of noise, therefore, this method is considered comparing the physiological status for being able to reflect stomach, just by more and more The concern of researcher;Electrogastrogram (electrogastrogram, EGG) record be it is non-invasive, it reflects stomach not With the summation of region myoelectrical activity.Because the non-invasive of EGG, measurement is convenient and does not interfere the activity of stomach, clinical research at present and It diagnoses in the majority with body surface detection.Stomach electricity of body surface weak output signal can also be collected from abdomen body-surface from enteron aisle, breathing, heart With the signal of skin etc., need to remove when these noise signals are stomach electroanalysis.
The detection and analysis of stomach electricity is an important branch of stomach and intestine dynamics research, is that functional gastrointestinal disease diagnoses One important evidence.But stomach electricity is found for the first time so far from nineteen twenty-one Alvarez, after it experienced the time of last 100 years, stomach electricity Progress it is slow, also greatly differ from each other still in the stage of verifying apart from extensive clinical application.Stomach electro-detection technology Development follows always after the development of ECG detecting technology.Relative maturity, detection accuracy are sufficient for ECG detecting technology at present To meet needs clinically, therefore electrocardiogram acquisition and the mode of analysis are substantially stationary.And ECG detecting skill is being indiscriminately imitated always The stomach electro-detection of art, also stopped development therewith.Although it has been realized that electro-gastric signals have amplitude compared with electrocardio Low, the features such as frequency is low, signal-to-noise ratio is low, there is biggish difficulty on electro-gastric signals are acquired and analyzed, these are technical Obstacle is not overcome effectively so far.Therefore clinical investigators are difficult to obtain satisfied electro-gastric signals, to its validity and Reliability is queried.These query the research for making engineering staff take for stomach electricity in turn again, actual clinical value It is not high, and abandon the exploitation of new technology.Obviously, the key for breaking this deadlock is to analyze stomach electro-detection technology and data Comprehensive update of processing method.
Therefore the invention proposes a kind of equipment that can be used for alimentary canal electricity physiological signal acquisition process display one, especially It is that can realize different colours or ash in the different zones of display using sacculus flexible displays made of flexible display material Degree display, so that home position manifestation electricity physiological signal is movable strong and weak directly in alimentary canal and is distributed.Wherein multi-channel electrode fills It sets for realizing the acquisition of alimentary canal electricity physiological signal, multichannel amplification and processing unit are for realizing alimentary canal electricity physiological signal Acquisition and processing in real time, and by alimentary canal electricity physiological signal be converted on sacculus flexible displays corresponding region different colours or Gray scale is shown.The visualization of alimentary canal electricity physiological signal studies Gastroenterology and is of great significance with clinical application.However It is currently used in the technological obsolescence of alimentary canal electrophysiologicalsignal signal detection, and most of time is not to acquire in real time, Real time visible Change.But it first acquires, then processed offline.Visualization device is also common computer monitor, visual information is mapped in aobvious Show on the alimentary canal model on device, it cannot intuitively observational record user alimentary canal crawler behavior data and wave activity.This Invention is able to solve the above problem, and the equipment can acquire alimentary canal electricity physiological signal in real time and handle, and alimentary canal is electric Physiological signal can intuitively reflect alimentary canal crawler behavior and alimentary canal electricity physiological signal in alimentary canal inner surface real-time display Synchronism, thus the research of assist digestion clinical practice and the actual monitoring diagnosis and treatment needs clinically to case.
Brain wave visualization device of the present invention mainly uses electrochromism (Electrochromism, EC) material. The material ultraviolet, visible light or (and) optical properties (transmissivity, reflectivity or absorptivity) of near infrared region are powered on outside The phenomenon that stable reversible change is generated under field action shows as the reversible change of color and transparency in appearance.Electroluminescent change Device made of color material has bistable state, ignores that blind angle, contrast are high, manufacturing cost is low, operating temperature range is wide, driving is electric The advantages that forcing down, be rich in color, can be applied to electrochromic intelligent window, automobile automatic anti-glare rearview mirror, electrochromism glasses, The fields such as goggles, smart card, intelligent label, instrument show, outdoor advertising.For Flexible Displays application, mainly using organic Electrochromic material.Organic electrochromic material includes small organic molecule electrochromic material and Polymer Electrochromic material 2 Major class.Wherein small organic molecule electrochromic material mainly includes Viologen Compounds, triphenylamine and its derivative etc., this kind ofization Color can be changed in electrode surface and solution by closing object.Conducting polymer is also a kind of important electrochromic material, type Various and color change is various, representative for Polypyrrole derivatives, polythiofuran derivative and polyaniline derivative etc..Organic Electricity Causing off-color material to have, color change is fast, memory effect is strong, loss is low, color is various, transmitance difference height etc. under different conditions Advantage.
Therefore it the invention proposes the equipment that can be used for alimentary canal electricity physiological signal acquisition process display one, especially adopts The sacculus flexible displays made of flexible display material can realize that different colours or gray scale are aobvious in the different zones of display Show, so that home position manifestation electricity physiological signal is movable strong and weak directly in alimentary canal and is distributed.Wherein multi-channel electrode device is used In the acquisition for realizing alimentary canal electricity physiological signal, multichannel amplification and processing unit putting for realizing alimentary canal electricity physiological signal Big and processing in real time, and alimentary canal electricity physiological signal is converted into corresponding region different colours or gray scale on sacculus flexible displays Display.The equipment has compact-sized, intuitive real-time in-situ display alimentary canal electricity physiological signal function, for Gastroenterology Research has great importance with clinical application.
Summary of the invention
It is an object of the invention to propose a kind of equipment that can be used for alimentary canal electricity physiological signal acquisition process display one, It especially with made of flexible display material, is brought into alimentary canal by digestive endoscope when in use, after reaching designated position Sacculus flexible displays inflation makes multi-channel electrode device be in close contact alimentary canal inner surface raw to acquire alimentary canal electricity Manage signal, the amplification and processing of process, finally the different zones of sacculus flexible displays in different colors or gray scale shows this The electricity physiological signal in region is movable strong and weak and is distributed, and operator, which carries out observation by digestive endoscope, can get the information.
To achieve the above object, the present invention is using technical solution: it includes multi-channel electrode device, multichannel amplification with Processing unit, sacculus flexible displays, external treatment and display unit and power supply;Multi-channel electrode device and alimentary canal inner surface Contact, the output end of multi-channel electrode device amplifies with multichannel to be connected with the input terminal of processing unit, multichannel amplification and place One output end of reason unit is connected with the input terminal of sacculus flexible displays, multichannel amplification and processing unit another is defeated Outlet is connected with external treatment with the input terminal of display unit, and power supply is used to be multi-channel electrode device, multichannel amplification and place Unit, sacculus flexible displays are managed, external treatment is powered with display unit.
The multi-channel electrode device: the connection of electrode and electrode and the multichannel amplification and processing unit of multichannel Conducting wire;
The electrode is sheet metal electrode, amplifies with multichannel and be connected with processing unit by connecting wire, is used for The acquisition for realizing alimentary canal electricity physiological signal, is converted to the electronics in metallic conductor for the ion directed flow of bioelectrical signals and determines To flowing;
The connecting wire is copper or ag material, is cladded with insulating materials, realization electrode and multichannel amplification and handles list The connection of member;
The multichannel amplification includes multi-channel amplifier and analog filter with processing unit, for alimentary canal is electric Physiological signal filters according to selected frequency range and is converted into driving signal, and connect with sacculus flexible displays, to control in real time It makes and activates sacculus flexible displays corresponding region;
The sacculus flexible displays are wrapped in digestive endoscopy distal outer before inflation, are brought by digestive endoscopy to digestion Appointed part in road, sacculus flexible displays have spheroidal shape after inflatable body or the expansion of filling liquid body, can will be attached Outer surface multi-channel electrode device be in close contact alimentary canal inner surface;The display area of the sacculus flexible displays is divided into Different display subregions corresponding from electrode each in multi-channel electrode device, each display subregion is by multi-layer film structure group At, respectively transparent support sealant from inside to outside, transparency conducting layer, electrochromic layer, electrolyte layer, another electrochromism Layer, another transparency conducting layer and another transparent support sealant seal against each other between each display subregion and electric insulation, ball The input terminal of capsule flexible displays amplifies with multichannel realizes that signaling interface is connect with the output end of processing unit, can receive biography The defeated driving signal to come, and some display area of sacculus flexible displays is activated, which can show different Color or different tonal gradations, represent different alimentary canal electricity physiological signal intensity;The display result of sacculus flexible displays is logical Digestive endoscopy is crossed to observe;
The external treatment and display unit is located in vitro, is computer based digital processing system, with other classes The electricity physiological signal processing workstation of type is similar, and principle is not described in detail herein, and external treatment receives multichannel with display unit and puts The alimentary canal electricity physiological signal exported with processing unit greatly, and be digitally converted, it handles and simultaneously shows on the computer screen;
The power supply is multi-channel electrode device, multichannel amplification and processing unit, sacculus flexible displays and outside Processing is powered with display unit.
The working principle of the invention is such that firstly, sacculus flexible displays are wrapped in digestive endoscopy before inflation Distal outer is brought by digestive endoscopy to appointed part in alimentary canal, and sacculus flexible displays are expanded by inflatable body or filling liquid body There is spheroidal shape afterwards, the multi-channel electrode device for being attached to outer surface can be in close contact alimentary canal inner surface, it is real The acquisition of existing alimentary canal electricity physiological signal, multichannel amplification and processing unit for realizing alimentary canal electricity physiological signal amplification and Processing in real time, and alimentary canal electricity physiological signal is converted into corresponding region different colours or gray scale on sacculus flexible displays and is shown Show, the display result of sacculus flexible displays is observed by digestive endoscopy;The working principle of the sacculus flexible displays is as follows: The display area of the sacculus flexible displays is divided into different display subregions corresponding from electrode each in multi-channel electrode device, Each display subregion is made of multi-layer film structure, and respectively transparent support sealant, transparency conducting layer are electroluminescent from inside to outside Photochromic layer, electrolyte layer, another electrochromic layer, another transparency conducting layer and another transparent support sealant, each display It is sealed against each other between region and electric insulation, therefore to receive its respectively corresponding by processed each for each display subregion Electrode EEG signals collected establish corresponding electric field between two transparency conducting layers, electrochromic layer are made to change colour.
The present invention is by adopting the above-described technical solution, have the advantages that
1, acquisition in real time and processing alimentary canal electricity physiological signal, and it is dynamic in real time aobvious on sacculus flexible displays in real time Show the alimentary canal bioelectrical activity of alimentary canal different zones.It can be used for the detection and analysis of clinical alimentary canal electricity physiological signal Deng;
2, compact-sized, at low cost, convenient and easy.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention;
Fig. 2 uses schematic diagram for of the invention;
Fig. 3 is the connection schematic diagram of multi-channel electrode device;
Fig. 4 is the structural schematic diagram of sacculus flexible displays.
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and examples: as illustrated in the accompanying drawings from 1 to 3, multi-channel electrode device 1, multichannel amplifies and processing unit 2, sacculus flexible displays 3, external treatment and display unit 4 and power supply 5;Multi-channel electrode Device 1 is contacted with alimentary canal inner surface, the input of output end and the multichannel amplification and processing unit 2 of multi-channel electrode device 1 End is connected, and multichannel amplification is connected with an output end of processing unit 2 with the input terminal of sacculus flexible displays 3, multichannel Amplification is connected with the another output of processing unit 2 with external treatment with the input terminal of display unit 4, and power supply 5 is for being more Pathway electrode arrangement 1, multichannel amplification are carried out with processing unit 2, sacculus flexible displays 3 and external treatment and display unit 4 Power supply.
The multi-channel electrode device 1: the amplification of electrode 1.1 and electrode and multichannel and the processing unit of multichannel Connecting wire 1.2;
The electrode 1.1 is sheet metal electrode, is connected with multichannel amplification with processing unit 2 by connecting wire, For realizing the acquisition of alimentary canal electricity physiological signal, the ion directed flow of bioelectrical signals is converted into the electricity in metallic conductor Sub- directed flow;
The connecting wire 1.2 be copper or ag material, be cladded with insulating materials, realize electrode 1.1 and multichannel amplification with The connection of processing unit 1.2;
The multichannel amplification and processing unit 2 include multi-channel amplifier and analog filter, are used for alimentary canal Electricity physiological signal filters according to selected frequency range and is converted into driving signal, and connect with sacculus flexible displays 3, thus in real time It controls and activates 3 corresponding region of sacculus flexible displays;
The sacculus flexible displays 3 are wrapped in digestive endoscopy distal outer before inflation, are brought by digestive endoscopy to disappearing Change appointed part in road, sacculus flexible displays 3 have spheroidal shape after inflatable body or the expansion of filling liquid body, can incite somebody to action The multi-channel electrode device 1 for being attached to outer surface is in close contact alimentary canal inner surface;The display area of the sacculus flexible displays 3 It is divided into different display subregions corresponding from electrode 1.1 each in multi-channel electrode device 1, each display subregion is by multi-layer thin Membrane structure composition, from inside to outside respectively transparent support sealant, transparency conducting layer, electrochromic layer, electrolyte layer, another electricity Mutagens chromatograph, another transparency conducting layer and another transparent support sealant, seal against each other between each display subregion and electrically Insulation, the input terminal of sacculus flexible displays 3 amplifies with multichannel realizes that signaling interface is connect with the output end of processing unit 2, It can receive the driving signal transmitted, and activate some display area of sacculus flexible displays 3, which can It shows different color or different tonal gradations, represents different alimentary canal electricity physiological signal intensity;Sacculus flexible displays 3 Display result is observed by digestive endoscopy;
The external treatment and display unit 4 is located in vitro, is computer based digital processing system, with other classes The electricity physiological signal processing workstation of type is similar, and principle is not described in detail herein, and external treatment receives multichannel with display unit 4 and puts The alimentary canal electricity physiological signal exported with processing unit 2 greatly, and be digitally converted, handle and show on the computer screen Show;
The power supply 5 is multi-channel electrode device 1, multichannel amplification and processing unit 2,3 He of sacculus flexible displays External treatment and display unit 4 are powered.
When specifically used, sacculus flexible displays 3 are wrapped in digestive endoscopy distal outer before inflation first, by digesting Scope is brought to appointed part in alimentary canal, and sacculus flexible displays 3 have similar sphere after inflatable body or the expansion of filling liquid body Shape, can will be attached to outer surface multi-channel electrode device 1 be in close contact alimentary canal inner surface, realize alimentary canal electro physiology The acquisition of signal, multichannel amplification are handled with processing unit 2 for realizing the amplification of alimentary canal electricity physiological signal and in real time, and will Alimentary canal electricity physiological signal is converted into corresponding region different colours or gray scale on sacculus flexible displays 3 and shows, sacculus curved surface is aobvious Show that the display result of device 3 is observed by digestive endoscopy.
What has been described above is only an embodiment of the present invention, and the common sense such as well known specific structure and characteristic are not made herein in scheme Excessive description, technical field that the present invention belongs to is all before one skilled in the art know the applying date or priority date Ordinary technical knowledge can know the prior art all in the field, and have using routine experiment hand before the date The ability of section, one skilled in the art can improve and be implemented in conjunction with self-ability under the enlightenment that the application provides This programme, some typical known features or known method should not become one skilled in the art and implement the application Obstacle.It should be pointed out that for those skilled in the art, without departing from the structure of the invention, can also make Several modifications and improvements out, these also should be considered as protection scope of the present invention, these all will not influence the effect that the present invention is implemented Fruit and patent practicability.The scope of protection required by this application should be based on the content of the claims, the tool in specification The records such as body embodiment can be used for explaining the content of claim.

Claims (8)

1. alimentary canal electro physiology visualization device, it is characterised in that: it includes multi-channel electrode device, multichannel amplification and processing Unit, sacculus flexible displays, external treatment and display unit and power supply;Multi-channel electrode device connects with alimentary canal inner surface Touching, the output end of multi-channel electrode device amplifies with multichannel to be connected with the input terminal of processing unit, multichannel amplification and processing One output end of unit is connected with the input terminal of sacculus flexible displays, another output of multichannel amplification and processing unit End is connected with external treatment with the input terminal of display unit, and power supply is used to be multi-channel electrode device, multichannel amplification and processing Unit, sacculus flexible displays, external treatment are powered with display unit.
2. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: multi-channel electrode device includes The connecting wire of electrode and electrode and the multichannel amplification and processing unit of multichannel;
The electrode is sheet metal electrode, amplifies with multichannel and be connected with processing unit by connecting wire;
The connecting wire is copper or ag material, is cladded with insulating materials, realizes electrode and multichannel amplification and processing unit Connection.
3. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: multichannel amplification and processing are single Member includes amplifier and analog filter.
4. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: sacculus flexible displays are electricity Cause off-color material.
5. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: sacculus flexible displays have It is may expand after elasticity, inflatable body or filling liquid body as sphere or analogous shape.
6. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: sacculus flexible displays are shown Show that region is divided into different display subregions corresponding from electrode each in multi-channel electrode device, each display subregion is by multilayer Membrane structure composition, respectively transparent support sealant, transparency conducting layer, electrochromic layer, electrolyte layer are another from inside to outside Electrochromic layer, another transparency conducting layer and another transparent support sealant, seal against each other between each display subregion and electricity It draws last breath edge.
7. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: sacculus flexible displays make Used time brings alimentary canal by digestive endoscopy.
8. alimentary canal electro physiology visualization device according to claim 1, it is characterised in that: sacculus flexible displays are shown Show result by digestive endoscopy to observe.
CN201810979308.3A 2018-08-27 2018-08-27 Alimentary canal electro physiology visualization device Pending CN109044328A (en)

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