CN109044278A - A kind of double fluorescent tracing imaging devices - Google Patents
A kind of double fluorescent tracing imaging devices Download PDFInfo
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- CN109044278A CN109044278A CN201810937905.XA CN201810937905A CN109044278A CN 109044278 A CN109044278 A CN 109044278A CN 201810937905 A CN201810937905 A CN 201810937905A CN 109044278 A CN109044278 A CN 109044278A
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- video camera
- control device
- shell
- imaging devices
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- 238000003384 imaging method Methods 0.000 title claims abstract description 19
- 230000005284 excitation Effects 0.000 claims abstract description 22
- 230000001154 acute effect Effects 0.000 claims abstract description 5
- 230000001681 protective effect Effects 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 3
- 230000003760 hair shine Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000523 sample Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000000700 radioactive tracer Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses a kind of double fluorescent tracing imaging devices, including computer, shell, phase Look mirror, first video camera, second video camera, control device, excitation light source, the shell is equipped with excitation light source, shell is equipped with light well, the phase Look mirror, first video camera, second video camera, control device is set to enclosure interior, and first video camera camera lens face light well, the phase Look mirror is set between light well and the first video camera, the angle between line and phase Look mirror between light well and the camera lens of the first video camera is acute angle, second video camera is set to the side of phase Look mirror, the camera lens of second video camera is towards phase Look mirror, the control device respectively with the first video camera, second video camera, computer connection, the shell is equipped with regulation button, power interface, the regulation button is electrically connected with control device , the power interface is electrically connected with the first video camera, the second video camera, control device respectively.
Description
Technical field
The present invention relates to medical imaging technology field, specially a kind of double fluorescent tracing imaging devices.
Background technique
Tracer experiment is exactly that studied object (certain compound or biomolecule or certain class cell etc.) is marked, and is drawn
Enter a marker as probe, by observing the whereabouts of probe, then tracks tracer in complicated biosystem or water body
Position, quantity and dynamic change in vivo or in vitro, the case where understanding its distribution, movement and convert.
Tracer is observation, research and behavior or property of the measurement something in assignment procedure and a kind of label being added
Object.Indocyanine green (ICG), methylenum careuleum (MB) are two kinds of medicine tracers, are used as chemical indicator, dyestuff, biological stain
It is used with drug.Medical worker, when the trend of patient's body detects, is needing to fill using fluorescence imaging to two kinds of drugs
It sets and is irradiated imaging, since the spectral absorbance values difference of two kinds of drugs needs to be shone by two different equipment
Observation is penetrated, causes detection time longer in this way, efficiency is lower.
Summary of the invention
The present invention provides a kind of double fluorescent tracing imaging devices, in shell aiming at deficiencies of the prior art
Two video cameras of installation in vivo, are separated different spectrum using phase Look mirror, can be examined simultaneously to two kinds of tracers
It surveys, solves the prior art and detection is carried out to two kinds of drugs to need to switch different equipment cumbersome come what is detected, save
Time improves efficiency, increases the convenience used.
To achieve the above object, invention provides the following technical solutions:
A kind of double fluorescent tracing imaging devices, including computer further include shell, phase Look mirror, the first video camera, second take the photograph
Camera, control device, excitation light source, the shell are equipped with excitation light source, and the excitation light source includes MB illuminator, ICG illuminator,
Shell is equipped with light well, and the phase Look mirror, the first video camera, the second video camera, control device are set to enclosure interior, and the
The camera lens face light well of one video camera, the phase Look mirror are set between light well and the first video camera, and light well is taken the photograph with first
The angle between line and phase Look mirror between the camera lens of camera is acute angle, and second video camera is set to the side of phase Look mirror,
The camera lens of second video camera connects with the first video camera, the second video camera, computer respectively towards phase Look mirror, the control device
It connects, the shell is equipped with regulation button, power interface, and the regulation button is electrically connected with control device, the power interface
It is electrically connected respectively with the first video camera, the second video camera, control device.
Preferably, the control device is equipped with wireless module, and control device is connected by wireless module and computer radio
It connects, the wireless module is bluetooth or wifi.
Preferably, the shell is equipped with USB interface, and the control device is connect by data line with computer.
Preferably, the line between the light well and the camera lens of the first video camera and the angle between phase Look mirror are 45 °.
Preferably, the shell is equipped with memory card slot, is equipped with storage card in memory card slot.
Preferably, battery is equipped in the shell, the battery is filled with the first video camera, the second video camera, control respectively
It sets, power interface electrical connection.
Preferably, the shell includes casing, handle, and the casing is connect with handle, and the handle is arc structure, institute
Regulation button is stated set on grip surface, the light well is set to the middle position of casing end, and the excitation light source is set to entering light
Around hole.
Preferably, the MB illuminator, ICG illuminator are circumferentially set to around light well.
Preferably, the end of the casing is equipped with protection eyeglass, and the light well, excitation light source are set to protective glass piece
Inside.
Compared with prior art, advantageous effect of the invention is:
1, the present invention installs two video cameras in shell, is separated different spectrum using phase Look mirror, Neng Goutong
When two kinds of tracers are detected, solve the prior art to two kinds of drugs carry out detection need to switch different equipment come into
Row detects cumbersome, saves the time, improves efficiency, increases the convenience used.
2, for the present invention using being wirelessly attached with computer, route is saved in the transmission of real-time perfoming image data, is used
Get up more convenient, avoid the constraint of route, allows using more flexible.
3, the present invention can be connect by data line with computer, can prevent the unstable of wireless transmission, while can
Transmission speed is improved, complementary with wireless transmission, one of transmission mode damage can be used another way and connect with computer,
Guarantee the reliability connecting with computer.
4, the present invention is equipped with storage card, can be saved in real time to detection image, convenient for carrying out idagnostic logout, also can
Image is carried out convenient for doctor to repeat viewing, avoids carrying out inspection observation to patient for a long time, reduction is not relaxed caused by patient
It is suitable.
5, the present invention is equipped with battery, can be used by battery power supply, can save the cumbersome of route by battery, simplifies
It is flexible and convenient using more enabling using step, it can also be directly connected to power supply and carry out using avoiding what battery power shortage was not available from asking
Topic, guarantees the reliability used.
6, casing of the invention is connect with handle, and the handle is arc structure, and entire mechanism is in handgun shape, convenient for making
The grasping of user, increase comforts of use, the regulation button be set to grip surface, operator can in real time according to observation away from
It is easy to use from come the adjusting that carries out focal length.
7, the present invention is equipped with protection eyeglass in the end of casing, can play a protective role to excitation light source, avoid exciting
Light source is damaged by external force, while be can be avoided external dust and being entered enclosure interior, it is ensured that the clear and device of image uses the longevity
Life.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is housing forward end structural schematic diagram of the invention.
In figure: 1- shell；101- casing；102- handle；103- protects eyeglass；104- light well；2- phase Look mirror；3- first
Video camera；4- control device；5- regulation button；6- battery；The second video camera of 7-；8- excitation light source；801-MB illuminator；802-
ICG illuminator.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment one,
A kind of double fluorescent tracing imaging devices, including the camera shooting of computer, shell 1, phase Look mirror 2, the first video camera 3, second
Machine 7, control device 4, excitation light source 8, the shell 1 be equipped with excitation light source 8, the excitation light source 8 include MB illuminator 801,
ICG illuminator 802, ICG illuminator 802 are the diode of launch wavelength 760-810nm near infrared light, 801 launch wavelength of MB illuminator
The diode of 600-660nm near infrared light, shell 1 are equipped with light well 104, and the phase Look mirror 2, the first video camera 3, second are taken the photograph
Camera 7, control device 4 are set to inside shell 1, and the camera lens face light well 104 of the first video camera 3, the first video camera 3 are
Infrared camera, is equipped with the imaging probe of detectable wavelength 820-900nm light on the first video camera 3, and the second video camera 7 is equipped with can visit
The imaging probe of wavelength 690-900nm light is surveyed, the phase Look mirror 2 is set between light well 104 and the first video camera 3, light well
The angle between line and phase Look mirror 2 between 104 and the camera lens of the first video camera 3 is acute angle, acute angle degree in this embodiment
It is 45 °, convenient for the location arrangements of the second video camera 7, second video camera 7 is set to the side of phase Look mirror 2, the second video camera 7
Camera lens towards phase Look mirror 2, patient is irradiated by excitation light source 8, MB and the ICG absorption spectrum of patient's body are later right
After issue fluorescence, fluorescence is entered inside shell 1 by light well 104, and the fluorescence issued by ICG, which passes through phase Look mirror 2 and enters first, to be taken the photograph
Camera 3, the fluorescence that MB is issued are reflected into the second video camera 7 through phase Look mirror.Two video cameras are installed in shell 1, utilize phase
Look mirror 2 separates different spectrum, can detect simultaneously to two kinds of tracers, solve the prior art to two kinds of medicines
Object carries out detection and needs to switch different equipment to be detected cumbersome, saves the time, improves efficiency, increases use
Convenience.
The control device 4 is connect with the first video camera 3, the second video camera 7, computer respectively, and control device 4 is PLC
Either single-chip microcontroller, control device 4 to computer, see the image transmitting of the first video camera 3 and the second video camera 7 for doctor
It surveys, the shell 1 is equipped with regulation button 5, power interface, and the regulation button 5 is electrically connected with control device 4, passes through adjusting
Button 5 can adjust the focal length of the first video camera 3 and the second video camera 7, Principles of Regulation and video camera, camera class seemingly, ability
The technical staff in domain is easily achieved, it is ensured that image understands, the power interface respectively with the first video camera 3, the second video camera
7, control device 4 is electrically connected, and is equipped with battery 6 in the shell 1, the battery 6 respectively with the first video camera 3, the second video camera
7, control device 4, power interface electrical connection are powered use in use, can directly connect by power supply line with socket, are
Convenience can also not use power supply line, in advance that battery 6 is fully charged, in use, being powered by the battery 6 in shell 1
, more succinctly, conveniently.
The control device 4 is equipped with wireless module, and control device 4 is connect by wireless module with computer radio, institute
Stating wireless module is bluetooth or wifi, and simple, quick, saving route operates more convenient.
The shell 1 includes casing 101, handle 102, and the casing 101 is connect with handle 102, and the handle 102 is circle
Arc structure, entire shell is similar and gun structure, the regulation button 5 are set to 102 surface of handle, convenient for adjusting, the entering light
Hole 104 is set to the middle position of 101 end of casing, and the excitation light source 8 is set to around light well 104, the MB illuminator
801, ICG illuminator 802 is circumferentially set to around light well 104, and MB illuminator 801, ICG illuminator 802, which separate, individually surrounds one
Circle is arranged in circle or uniform intervals.
The end of the casing 101 is equipped with protection eyeglass 103, and the light well 104, excitation light source 8 are set to protective glass
The inside of piece 103.It can play a protective role to excitation light source 8, avoid excitation light source 8 from being damaged by external force, can be avoided simultaneously
External dust enters inside shell 1, it is ensured that the service life of the clear and device of image.
The shell 1 is equipped with memory card slot, is equipped with storage card in memory card slot, SD card storage card can be used.It can be right
Detection image is saved in real time, convenient for carrying out idagnostic logout, can also be carried out repeating viewing to image convenient for doctor, be avoided growing
Time carries out inspection observation to patient, reduces uncomfortable caused by patient.
Embodiment two,
The shell 1 is equipped with USB interface, and the control device 4 is connect with computer by data line, can directly be used
Data line connects the device with computer, avoids that network is bad to cause transmission speed slow or unstable problem.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (9)
1. a kind of double fluorescent tracing imaging devices, including computer, it is characterised in that: further include shell, phase Look mirror, the first camera shooting
Machine, the second video camera, control device, excitation light source, the shell are equipped with excitation light source, and the excitation light source includes that MB shines
Lamp, ICG illuminator, shell are equipped with light well, and the phase Look mirror, the first video camera, the second video camera, control device are set to shell
Internal portion, and the camera lens face light well of the first video camera, the phase Look mirror are set between light well and the first video camera, entering light
The angle between line and phase Look mirror between hole and the camera lens of the first video camera is acute angle, and second video camera is set to phase color
The side of mirror, the camera lens of the second video camera towards phase Look mirror, the control device respectively with the first video camera, the second video camera,
Computer connection, the shell are equipped with regulation button, power interface, and the regulation button is electrically connected with control device, described
Power interface is electrically connected with the first video camera, the second video camera, control device respectively.
2. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: the control device is equipped with nothing
Wire module, control device are connect by wireless module with computer radio, and the wireless module is bluetooth or wifi.
3. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: the shell connects equipped with USB
Mouthful, the control device is connect by data line with computer.
4. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: the light well and the first camera shooting
The angle between line and phase Look mirror between the camera lens of machine is 45 °.
5. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: the shell is equipped with storage card
Slot, memory card slot is interior to be equipped with storage card.
6. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: battery is equipped in the shell,
The battery is electrically connected with the first video camera, the second video camera, control device, power interface respectively.
7. a kind of double fluorescent tracing imaging devices as described in claim 1, it is characterised in that: the shell includes casing, holds
The casing is connect with handle, and the handle is arc structure, and the regulation button is set to grip surface, the light well
Set on the middle position of casing end, the excitation light source is set to around light well.
8. a kind of double fluorescent tracing imaging devices as claimed in claim 7, it is characterised in that: the MB illuminator, ICG illuminator are equal
Circumferentially it is set to around light well.
9. a kind of double fluorescent tracing imaging devices as claimed in claim 7, it is characterised in that: the end of the casing, which is equipped with, to be protected
Protecting lens, the light well, excitation light source are set to the inside of protective glass piece.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810937905.XA CN109044278A (en) | 2018-08-16 | 2018-08-16 | A kind of double fluorescent tracing imaging devices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810937905.XA CN109044278A (en) | 2018-08-16 | 2018-08-16 | A kind of double fluorescent tracing imaging devices |
Publications (1)
| Publication Number | Publication Date |
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| CN109044278A true CN109044278A (en) | 2018-12-21 |
Family
ID=64686385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810937905.XA Pending CN109044278A (en) | 2018-08-16 | 2018-08-16 | A kind of double fluorescent tracing imaging devices |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111458320A (en) * | 2020-05-22 | 2020-07-28 | 南京诺源医疗器械有限公司 | Tracing system for tumor detection |
| CN114047623A (en) * | 2022-01-14 | 2022-02-15 | 济南显微智能科技有限公司 | Multispectral fluorescence endoscope |
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| CN114047623B (en) * | 2022-01-14 | 2022-04-05 | 济南显微智能科技有限公司 | Multispectral fluorescence endoscope |
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