CN109022251A - Refrigeration temperature control device based on biological 3D printing equipment - Google Patents
Refrigeration temperature control device based on biological 3D printing equipment Download PDFInfo
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- CN109022251A CN109022251A CN201810917762.6A CN201810917762A CN109022251A CN 109022251 A CN109022251 A CN 109022251A CN 201810917762 A CN201810917762 A CN 201810917762A CN 109022251 A CN109022251 A CN 109022251A
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- incubator
- air
- refrigeration
- biological
- temperature control
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/20—Heat exchange systems, e.g. heat jackets or outer envelopes the heat transfer medium being a gas
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
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- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of refrigeration temperature control devices based on biological 3D printing equipment, belong to clean disinfection system and temperature control technology field.The incubator of the refrigeration temperature control device is set on printing machine base, print structure is set in the inner cavity of incubator, air inlet, gas outlet and the air duct being connected to air inlet and air outlet are provided on incubator, air inlet is set on the side wall of incubator, and gas outlet is set on the inner top panel of incubator；Refrigeration structure is set on the air duct at the air inlet of the side wall of incubator, to the air cooling flowed into through air inlet；The cooling piece of refrigeration structure is set to the side-wall outer side of incubator, and fin is set to the two sides of cooling piece, and fan is set to the side of cooling piece, to radiate for cooling piece；Air cleaning structure setting is in the air duct above the inner top panel of incubator, to be filtered to the air after freezing；Disinfection and sterilization structure, is set on the inner top panel of incubator, to incubator internal irradiation.
Description
Technical field
The invention belongs to clean disinfection system and temperature control technology field more particularly to a kind of clean, sterilization and temperature are gathered
It controls in the refrigeration temperature control device based on biological 3D printing equipment of one.
Background technique
Due to the particularity of biological 3D printing, the printing environment of cleaning sterile and the temperature of control surrounding air are needed, so
And current biological 3D printer needs to guarantee by Biohazard Safety Equipment or other conditions the printing environment of cleaning sterile；Biology
Material category is more, and the temperature needed is also different, and for existing biometric print machine temperature control system, biomaterial is easy to appear stifled
The problems such as plug phenomenon, biological cell survival rate reduces.
Summary of the invention
The purpose of the present invention is to solve cleaning sterile environmental problem and environment needed for existing biological 3D printing
The climate control issues of air, the present invention provide a kind of refrigeration temperature control device based on biological 3D printing equipment.
A kind of refrigeration temperature control device based on biological 3D printing equipment of the invention is applied in biological 3D printing equipment,
Include:
Incubator is set on printing machine base, and print structure is set in the inner cavity of incubator, is set on the incubator
It is equipped with air inlet, gas outlet and the air duct being connected to the air inlet and air outlet, the air inlet is set to the incubator
Side wall on, the gas outlet is set on the inner top panel of the incubator；
Refrigeration structure is set in the air duct at the air inlet of the side wall of the incubator, to through the air inlet
The air cooling of inflow；
The refrigeration structure includes cooling piece, fin and fan, and the cooling piece is set to outside the side wall of the incubator
Side, the fin are set to the two sides of the cooling piece, and the fan is set to the side of the cooling piece, to for the system
Cold heat dissipation；
Air cleaning structure is set in the air duct above the inner top panel of the incubator, to the sky after freezing
Gas is filtered；
Disinfection and sterilization structure is set to the top side wall of the incubator, to kill to the incubator internal irradiation
Bacterium and virus in air.
Preferably, the refrigeration structure further include: water-cooled radiator is set to the air duct on the side wall of the incubator
In.
Preferably, the refrigeration structure is two, is respectively arranged at the two sides of the incubator, each refrigeration structure
A corresponding air inlet.
Preferably, the air cleaning structure uses FFU blower fan filtering unit.
Preferably, the cooling piece uses semiconductor chilling plate.
Preferably, the disinfection and sterilization structure uses ultraviolet disinfection lamp, and the ultraviolet disinfection lamp is to kill air
In bacterium and virus.
Preferably, it is provided with blower at the gas outlet, to suck the air in the air duct in the incubator.
Above-mentioned technical characteristic may be combined in various suitable ways or be substituted by equivalent technical characteristic, as long as can reach
To the purpose of the present invention.
The beneficial effects of the present invention are the biological 3D printing equipment with clean sterilization function of temperature control of the invention is got rid of
Dependence to Biohazard Safety Equipment by air cleaning structure, refrigeration structure and disinfection and sterilization structure is embodied as biological 3D printing
There is provided temperature-controllable cleaning sterile environment, to meet the printing requirement of high-temperature material and cryogenic material, also have noise it is small,
High reliablity, it is applied widely the advantages that.
Detailed description of the invention
Fig. 1 is a kind of three-dimensional knot of embodiment of the refrigeration temperature control device of the present invention based on biological 3D printing equipment
Structure schematic diagram；
Fig. 2 is the schematic diagram in the direction A-A in Fig. 1.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art without creative labor it is obtained it is all its
His embodiment, shall fall within the protection scope of the present invention.
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The present invention will be further explained below with reference to the attached drawings and specific examples, but not as the limitation of the invention.
As Figure 1-Figure 2, a kind of refrigeration temperature control device based on biological 3D printing equipment, sets applied to biological 3D printing
In standby, comprising:
Incubator 1 is set on printing machine base, and print structure is set in the inner cavity of incubator 1, is set on incubator 1
It is equipped with air inlet, gas outlet and the air duct being connected to air inlet and air outlet, air inlet is set on the side wall of incubator 1, out
Port is set on the inner top panel of incubator 1；
Refrigeration structure is set in the air duct at the air inlet of the side wall of incubator 1, to the sky flowed out through air inlet
Gas refrigeration；
Refrigeration structure includes cooling piece 2, fin 3 and fan 4, and cooling piece 2 is set to the side-wall outer side of incubator 1, fin 3
The two sides of cooling piece 2 are set to increase thermally conductive and refrigeration area, fan 4 is set to the side of cooling piece 2, to freeze
Piece 2 radiates；
Air cleaning structure 5 is set in the air duct above the inner top panel of incubator 1, to the air after freezing
It is filtered；
Disinfection and sterilization structure 6 is set to the top side wall of incubator 1, to kill in air to 1 internal irradiation of incubator
Bacterium and virus.
In the present embodiment, there is the biological 3D printing equipment of clean sterilization function of temperature control to get rid of to Biohazard Safety Equipment
It relies on, by air cleaning structure 5, refrigeration structure and disinfection and sterilization structure 6, is embodied as biological 3D printing and temperature-controllable is provided
The environment of cleaning sterile also has small noise, high reliablity, is applicable in meet the printing requirement of high-temperature material and cryogenic material
The advantages that range is wide
In a preferred embodiment, refrigeration structure further include: water-cooled radiator is set to the lateral wall of the incubator 1
On.
In a preferred embodiment, refrigeration structure is two, is respectively arranged at the two sides of incubator 1, each refrigeration structure
A corresponding air inlet, to guarantee the air cooling effect in incubator 1.
In a preferred embodiment, air cleaning structure 5 uses FFU blower fan filtering unit.Surrounding air in incubator 1
After flowing through refrigeration structure, FFU blower fan filtering unit is drawn by blower, surrounding air is filtered through high efficiency particulate air filter, filtering environmental
The fine particles such as the dust being mingled in air, filtered pure air are at the uniform velocity sent out in air outlet, to realize to air
Purification.
In the present embodiment, FFU blower fan filtering unit is equipped with first, efficient double-filtration net, and air filter efficiency can be improved,
And FFU blower fan filtering unit uses outer-rotor centrifugal fan, with the long-life, low noise, non-maintaining, vibration is small, can stepless-adjustment
The characteristics such as speed.The clean environment of higher level is obtained suitable for various environment.
In a preferred embodiment, cooling piece 2 uses semiconductor chilling plate.Semiconductor chilling plate is also thermoelectric module,
It is a kind of heat pump.Its advantages are no slide units, apply and are restricted in some spaces, and reliability requirement is high, no refrigeration
The occasion of agent pollution.It is a kind of Refrigeration Technique for generating negative thermal resistance, its main feature is that movement-less part, reliability is also relatively high.
In a preferred embodiment, disinfection and sterilization structure 6 uses ultraviolet disinfection lamp, and ultraviolet disinfection lamp is to kill sky
Bacterium and virus in gas etc., to provide sterile air environment for the air in incubator 1.
In the present embodiment, it can be killed using ultraviolet disinfection lamp including bacterial propagule, brood cell, mycobacterium, coronal
Virus, fungi, Richettsia and Chlamydia etc. provide sterile environment for biology 3D printing, make print platform and print to
Biomaterial on print platform is printed in sterile environment.
In a preferred embodiment, it is provided with blower at gas outlet, to suck the air in air duct in incubator 1.
In the present embodiment, the air in incubator 1 is drawn into air duct by going out air inlet by blower, is tied by refrigeration
It after structure is to air cooling, is flowed into air cleaning structure 5, filters in filtering environmental air and be mingled with by air cleaning structure 5
Fine particles, the filtered pure air such as dust at the uniform velocity sent out, be re-introduced into incubator 1 by air inlet/outlet,
It is irradiated the virus killed in surrounding air, bacterium to the air in incubator 1 using disinfection and sterilization structure 6, forms heat preservation
Circulation in pure air in case 1.
Finally, it should be noted that obviously, embodiments described above is a part of the embodiment of the present invention, is not all of
Embodiment, technical solution of the present invention is only illustrated with it, rather than its limitations.Based on the embodiments of the present invention, this field
It is to be appreciated by one skilled in the art that being possible to modify the technical solutions described in the foregoing embodiments, or to its middle part
Divide or all technical features are equivalently replaced, and these are modified or replaceed, it does not separate the essence of the corresponding technical solution
The range of technical solution of various embodiments of the present invention, and every other reality obtained without making creative work
Example is applied, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The indicating positions such as "horizontal", "inner", "outside" or positional relationship are to be based on the orientation or positional relationship shown in the drawings, merely to just
In description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with
Specific orientation construction and operation, therefore be not considered as limiting the invention.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should broadly understood, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For those of ordinary skill in the art, above-mentioned term can be understood in this hair according to concrete condition
Concrete meaning in bright.
Claims (7)
1. a kind of refrigeration temperature control device based on biological 3D printing equipment is applied in biological 3D printing equipment, which is characterized in that
Include:
Incubator (1) is set on printing machine base, and print structure is set in the inner cavity of incubator (1), the incubator
(1) air inlet, gas outlet and the air duct being connected to the air inlet and air outlet are provided on, the air inlet is set to described
On the side wall of incubator (1), the gas outlet is set on the inner top panel of the incubator (1)；
Refrigeration structure is set in the air duct at the air inlet of the side wall of the incubator (1), to through the air inlet stream
Air cooling out；
The refrigeration structure includes cooling piece (2), fin (3) and fan (4), and the cooling piece (2) is set to the incubator
(1) side-wall outer side, the fin (3) are set to the two sides of the cooling piece (2), and the fan (4) is set to the refrigeration
The side of piece (2), to radiate for the cooling piece (2)；
Air cleaning structure (5) is set in the air duct above the inner top panel of the incubator (1), to after freezing
Air is filtered；
Disinfection and sterilization structure (6), is set to the top side wall of the incubator (1), to the incubator (1) internal irradiation
Kill the bacterium in air and virus.
2. the refrigeration temperature control device according to claim 1 based on biological 3D printing equipment, which is characterized in that the refrigeration
Structure further include: water-cooled radiator is set on the lateral wall of the incubator (1).
3. the refrigeration temperature control device according to claim 1 or 2 based on biological 3D printing equipment, which is characterized in that described
Refrigeration structure is two, is respectively arranged at the two sides of the incubator (1), each corresponding air inlet of the refrigeration structure.
4. the refrigeration temperature control device according to claim 1 based on biological 3D printing equipment, which is characterized in that the air
Clean structure (5) uses FFU blower fan filtering unit.
5. the refrigeration temperature control device according to claim 1 based on biological 3D printing equipment, which is characterized in that the refrigeration
Piece (2) uses semiconductor chilling plate.
6. the refrigeration temperature control device according to claim 1 based on biological 3D printing equipment, which is characterized in that the disinfection
Disinfection structure (6) uses ultraviolet disinfection lamp, and the ultraviolet disinfection lamp is to kill bacterium and virus in air.
7. the refrigeration temperature control device according to claim 1 based on biological 3D printing equipment, which is characterized in that the outlet
It is provided with blower at mouthful, to suck the air in the air duct in the incubator (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810917762.6A CN109022251A (en) | 2018-08-13 | 2018-08-13 | Refrigeration temperature control device based on biological 3D printing equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810917762.6A CN109022251A (en) | 2018-08-13 | 2018-08-13 | Refrigeration temperature control device based on biological 3D printing equipment |
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|---|---|
| CN109022251A true CN109022251A (en) | 2018-12-18 |
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|---|---|---|---|
| CN201810917762.6A Pending CN109022251A (en) | 2018-08-13 | 2018-08-13 | Refrigeration temperature control device based on biological 3D printing equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110509549A (en) * | 2019-07-12 | 2019-11-29 | 杭州电子科技大学 | A kind of temperature control photo-crosslinking 3D cell printing machine |
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| EP3269798A1 (en) * | 2015-03-31 | 2018-01-17 | Dokkyo Medical University | Incubator provided with clean bench function, and incubator system |
| CN107839240A (en) * | 2017-11-16 | 2018-03-27 | 杭州捷诺飞生物科技股份有限公司 | The 3 D-printing method and device monitored in real time |
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| CN204320350U (en) * | 2014-11-21 | 2015-05-13 | 深圳市永盛旺实业有限公司 | The efficient superclean bench of continuous type |
| EP3269798A1 (en) * | 2015-03-31 | 2018-01-17 | Dokkyo Medical University | Incubator provided with clean bench function, and incubator system |
| CN105904733A (en) * | 2016-06-08 | 2016-08-31 | 杭州百桥医疗技术有限公司 | 3D biological printing device and method for bone biological materials |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110509549A (en) * | 2019-07-12 | 2019-11-29 | 杭州电子科技大学 | A kind of temperature control photo-crosslinking 3D cell printing machine |
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Application publication date: 20181218 |