CN109021431A - A kind of enhanced medical thin-film material - Google Patents

A kind of enhanced medical thin-film material Download PDF

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Publication number
CN109021431A
CN109021431A CN201810649458.8A CN201810649458A CN109021431A CN 109021431 A CN109021431 A CN 109021431A CN 201810649458 A CN201810649458 A CN 201810649458A CN 109021431 A CN109021431 A CN 109021431A
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acid
parts
methyl
glycol ester
diamides
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CN201810649458.8A
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Inventor
李苏杨
徐勤霞
成清明
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Suzhou Bec Biological Technology Co Ltd
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Suzhou Bec Biological Technology Co Ltd
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Priority to CN201810649458.8A priority Critical patent/CN109021431A/en
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2327/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers
    • C08J2327/02—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment
    • C08J2327/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
    • C08J2327/06—Homopolymers or copolymers of vinyl chloride
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2401/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2401/08—Cellulose derivatives
    • C08J2401/26—Cellulose ethers
    • C08J2401/28—Alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2403/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08J2403/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2433/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2433/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
    • C08J2433/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2463/00—Characterised by the use of epoxy resins; Derivatives of epoxy resins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2491/00—Characterised by the use of oils, fats or waxes; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides a kind of enhanced medical thin-film materials, using Corvic and epoxy resin as raw material, sago starch, polydiene propyl are added for-L-TARTARIC ACID diamides, 2- methyl -2, epihydric acid 2 methacrylic acid glycol ester, hydroxymethyl cellulose and epoxidized soybean oil, its component is respectively as follows: Corvic, and 40-50 parts；Epoxy resin, 20-30 parts；Sago starch, 5-8 parts；Polydiene propyl is for-L-TARTARIC ACID diamides, and 2-5 parts；Poly- methyl -2 2-, epihydric acid 2 methacrylic acid glycol ester, 2-5 parts；Hydroxymethyl cellulose, 1-5 parts；Epoxidized soybean oil, 5-10 parts.This medical thin-film material effectively the gas permeability of enhanced film, elasticity, high-low temperature resistant and the performances such as antibacterial can meet medical demand to improve the quality of film.

Description

A kind of enhanced medical thin-film material
Technical field
The present invention relates to field of medical materials, and in particular to a kind of enhanced medical thin-film material.
Background technique
Pvc material itself is harder, and after plasticizer is added, pvc material will become soft and flexible, just In processing and forming, medical product of various shapes can be made, be widely used in the manufacture of medical product at present.Currently, state The interior common plastics blood bag for saving blood platelet has the following problems that gas permeability is bad, and blood platelet breathing needs oxygen and arranges Standard requirements are far not achieved in carbon dioxide out, the oxygen transmission rate of common plastics blood bag, and common plastics blood bag is largely plasticized using DEHP, The precipitation of DEHP can be such that the pH value of platelet concentrate increases, and lead to the death of part blood platelet, be unfavorable for the preservation of blood platelet, Common plastics blood bag resistance to low temperature is poor simultaneously, bad to save to blood platelet.
But currently used medical thin-film material is mostly that therefore high-low temperature resistant, poor air permeability do not develop a kind of formula conjunction Reason, performance stabilization, good permeability, elasticity is good, energy high-low temperature resistant and the medical thin-film material with the good performances such as antibacterial are A problem urgently to be resolved.
Summary of the invention
In order to provide a kind of formula rationally, performance stabilization, good permeability, elasticity is good, can high-low temperature resistant and with good The medical thin-film material of the performances such as biocidal property, realizes the present invention.
To achieve the above object, the invention adopts the following technical scheme:
A kind of enhanced medical thin-film material adds sago starch, polydiene using Corvic and epoxy resin as raw material Propyl for-L-TARTARIC ACID diamides, poly- 2- methyl-epihydric acid methacrylic acid glycol ester, hydroxymethyl cellulose and Epoxidized soybean oil is made, and component is respectively as follows:
40-50 parts of Corvic；
20-30 parts of epoxy resin；
5-8 parts of sago starch；
Polydiene propyl replaces -2-5 parts of L-TARTARIC ACID diamides；
Poly- 2- methyl -2-5 parts of epihydric acid methacrylic acid glycol ester；
1-5 parts of hydroxymethyl cellulose；
5-10 parts of epoxidized soybean oil.
Further, polydiene propyl is as follows for the synthesis of-L-TARTARIC ACID diamides: by the L-TARTARIC ACID diethylester of 1eq, The allylamine of 5eq is added in anhydrous ether, 35-40 DEG C reaction 12-24 hours, suction filtration obtain white solid diallyl for- L-TARTARIC ACID diamides；By the white solid Diallyltartardiamide diamides, the 0.01eq diphenyl peroxide of 1eq Formyl is added in dehydrated alcohol, 20-30 DEG C reaction 12-72 hours, suction filtration obtains white solid polydiene propyl for-L- winestone Sour diamides.
Still further, polydiene propyl is for the white powder that-L-TARTARIC ACID diamides is that K value is 70-90.
Further, poly- methyl -2 2-, the synthesis of epihydric acid 2 methacrylic acid glycol ester are as follows: by the two of 1eq Methacrylic acid glycol ester is dissolved in anhydrous methylene chloride, and the metachloroperbenzoic acid of 1.2eq is added portionwise, and heats 42-45 DEG C reflux 12-24 hours, respectively with 5% sodium sulfite solution, 10% sodium bicarbonate solution, distilled water was washed twice, organic phase It is dry that anhydrous sodium sulfate is added, is concentrated to get methyl -2 grease 2-, epihydric acid 2 methacrylic acid glycol ester；By 1eq Grease 2- methyl-epihydric acid methacrylic acid glycol ester, 0.01eq dibenzoyl peroxide be added to it is anhydrous In ethyl alcohol, 20-30 DEG C reaction 12-72 hours, suction filtration obtain poly- methyl -2 2- of white solid, epihydric acid 2 methacrylic acid Glycol ester.
Still further, poly- methyl -2 2-, epihydric acid 2 methacrylic acid glycol ester is the white that K value is 60-80 Powder.
Preferably, a kind of enhanced medical thin-film material, component are respectively as follows:
45 parts of Corvic；
25 parts of epoxy resin；
7 parts of sago starch；
Polydiene propyl replaces -4 parts of L-TARTARIC ACID diamides；
Poly- 2- methyl -4 parts of epihydric acid methacrylic acid glycol ester；
3 parts of hydroxymethyl cellulose；
8 parts of epoxidized soybean oil.
By above-mentioned technical proposal, compared with prior art, the present invention is added to polydiene propyl for-two acyl of L-TARTARIC ACID Amine and poly- methyl -2 2-, this two kinds of excellent auxiliary agents of epihydric acid 2 methacrylic acid glycol ester, so that medical thin-film material Have many advantages, such as formula rationally, performance is stable, good permeability of film, elasticity is good, can high-low temperature resistant and have it is good antibacterial, Enhance the quality and purposes of medical thin-film material；And polydiene propyl is for-L-TARTARIC ACID diamides and poly- 2- methyl -2,3- The raw material of glycidic acid methacrylic acid glycol ester synthesis be easy to get and inexpensively, synthesis technology is simple, is easily achieved.
Specific embodiment
Present invention is further described in detail With reference to embodiment.It should be understood that following embodiment is only For illustrating the present invention, limitation of the scope of the invention but should not be understood as.
Embodiment 1
Polydiene propyl for-L-TARTARIC ACID diamides preparation
The allylamine 28.5kg of L-TARTARIC ACID diethylester 20kg, 5eq of 1eq are added in anhydrous ether, 40 DEG C of reactions 18 are small When, suction filtration obtains white solid Diallyltartardiamide diamides 19.2kg, by two allyl of the white solid of 1eq Base is added in dehydrated alcohol for-L-TARTARIC ACID diamides 19.2kg, 0.01eq dibenzoyl peroxide 0.19kg, and 30 DEG C anti- Answer 60 hours, suction filtration obtains white solid polydiene propyl for-L-TARTARIC ACID diamides 15.8kg, measure polydiene propyl for- The K value of L-TARTARIC ACID diamides is 86.
Embodiment 2
The preparation of poly- 2- methyl-epihydric acid methacrylic acid glycol ester
The ethylene glycol dimethacrylate 20kg of 1eq is dissolved in anhydrous methylene chloride, the m-chloro peroxide of 1.2eq is added portionwise Benzoic acid 20.8kg heats 42-45 DEG C and flows back 18 hours, respectively with 5% sodium sulfite solution, 10% sodium bicarbonate solution, steams Distilled water washes twice, and organic anhydrous sodium sulfate that is added to is dry, is concentrated to get methyl -2 grease 2-, epihydric acid 2 methyl-prop Olefin(e) acid glycol ester 18.2kg；By grease 2- methyl-epihydric acid methacrylic acid glycol ester 18.2kg of 1eq, 0.01eq dibenzoyl peroxide 0.19kg is added in dehydrated alcohol, and 30 DEG C are reacted 60 hours, and it is poly- that suction filtration obtains white solid 2- methyl-epihydric acid methacrylic acid glycol ester 14.5kg.Measure poly- 2- methyl-epihydric acid methyl-prop The K value of olefin(e) acid glycol ester is 75.
Embodiment 3
A kind of enhanced medical thin-film material adds sago starch, polydiene using Corvic and epoxy resin as raw material Propyl for-L-TARTARIC ACID diamides, poly- 2- methyl-epihydric acid methacrylic acid glycol ester, hydroxymethyl cellulose and Epoxidized soybean oil is made, and component is respectively as follows:
Corvic 40kg；
Epoxy resin 20kg；
Sago starch 5kg；
Polydiene propyl is for-L-TARTARIC ACID diamides 2kg；
Poly- 2- methyl-epihydric acid methacrylic acid glycol ester 2kg；
Hydroxymethyl cellulose 1kg；
5 kg of epoxidized soybean oil.
Embodiment 4
A kind of enhanced medical thin-film material adds sago starch, polydiene using Corvic and epoxy resin as raw material Propyl for-L-TARTARIC ACID diamides, poly- 2- methyl-epihydric acid methacrylic acid glycol ester, hydroxymethyl cellulose and Epoxidized soybean oil is made, and component is respectively as follows:
Corvic 50kg；
Epoxy resin 30kg；
Sago starch 8kg；
Polydiene propyl is for-L-TARTARIC ACID diamides 5kg；
Poly- 2- methyl-epihydric acid methacrylic acid glycol ester 5kg；
Hydroxymethyl cellulose 5kg；
Epoxidized soybean oil 10kg.
Embodiment 5
A kind of enhanced medical thin-film material adds sago starch, polydiene using Corvic and epoxy resin as raw material Propyl for-L-TARTARIC ACID diamides, poly- 2- methyl-epihydric acid methacrylic acid glycol ester, hydroxymethyl cellulose and Epoxidized soybean oil is made, and component is respectively as follows:
Corvic 45kg；
Epoxy resin 25kg；
Sago starch 7kg；
Polydiene propyl is for-L-TARTARIC ACID diamides 4kg；
Poly- 2- methyl-epihydric acid methacrylic acid glycol ester 4kg；
Hydroxymethyl cellulose 3kg；
8 kg of epoxidized soybean oil.
The medical film as made from the material of above-described embodiment is capable of gas permeability, the elasticity, resistance to height of effective enhanced film Mildly the performances such as antibacterial meet medical demand to improve the quality of film.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and Modification, these improvements and modifications also should be regarded as protection scope of the present invention.

Claims (5)

1. a kind of enhanced medical thin-film material, which is characterized in that using Corvic and epoxy resin as raw material, addition west Rice starch, polydiene propyl for-L-TARTARIC ACID diamides, poly- 2- methyl-epihydric acid methacrylic acid glycol ester, Hydroxymethyl cellulose and epoxidized soybean oil are made, and component is respectively as follows:
40-50 parts of Corvic；
20-30 parts of epoxy resin；
5-8 parts of sago starch；
Polydiene propyl replaces -2-5 parts of L-TARTARIC ACID diamides；
Poly- 2- methyl -2-5 parts of epihydric acid methacrylic acid glycol ester；
1-5 parts of hydroxymethyl cellulose；
5-10 parts of epoxidized soybean oil.
2. a kind of enhanced medical thin-film material according to claim 1, which is characterized in that the polydiene propyl for- The synthesis of L-TARTARIC ACID diamides is as follows: the allylamine of the L-TARTARIC ACID diethylester of 1eq, 5eq is added in anhydrous ether, 35-40 DEG C reaction 12-24 hours, suction filtration obtain white solid Diallyltartardiamide diamides；By the described white of 1eq Color solid Diallyltartardiamide diamides, 0.01eq dibenzoyl peroxide are added in dehydrated alcohol, and 20-30 DEG C Reaction 12-72 hours, suction filtration obtain white solid polydiene propyl for-L-TARTARIC ACID diamides.
3. a kind of enhanced medical thin-film material according to claim 1, which is characterized in that the poly- 2- methyl -2,3- The synthesis of glycidic acid methacrylic acid glycol ester is as follows: the ethylene glycol dimethacrylate of 1eq is dissolved in anhydrous dichloro In methane, be added portionwise the metachloroperbenzoic acid of 1.2eq, 42-45 DEG C of heating reflux 12-24 hours, respectively with 5% sulfurous Acid sodium solution, 10% sodium bicarbonate solution, distilled water wash twice, and organic anhydrous sodium sulfate that is added to is dry, are concentrated to get oily Object 2- methyl-epihydric acid methacrylic acid glycol ester；By grease 2- methyl-epihydric acid methyl of 1eq Acrylic acid glycol ester, 0.01eq dibenzoyl peroxide are added in dehydrated alcohol, 20-30 DEG C reaction 12-72 hours, filter Obtain the poly- 2- methyl-epihydric acid methacrylic acid glycol ester of white solid.
4. a kind of enhanced medical thin-film material according to claim 1 or 2, which is characterized in that the polydiene propyl It is the white powder that K value is 70-90 for-L-TARTARIC ACID diamides.
5. a kind of enhanced medical thin-film material according to claim 1 or 3, which is characterized in that the poly- 2- methyl- Epihydric acid methacrylic acid glycol ester is the white powder that K value is 60-80.
CN201810649458.8A 2018-06-22 2018-06-22 A kind of enhanced medical thin-film material Withdrawn CN109021431A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111574730A (en) * 2020-06-09 2020-08-25 江苏工程职业技术学院 Preparation method of polyepoxypropionic acid hydrogel
CN111576042A (en) * 2020-04-30 2020-08-25 王洛 Environment-friendly antibacterial plastic bag
JP7082520B2 (en) 2018-05-07 2022-06-08 ナガセケムテックス株式会社 Reactive composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105038017A (en) * 2015-07-24 2015-11-11 南通慧源塑胶有限公司 Medical thin film material

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105038017A (en) * 2015-07-24 2015-11-11 南通慧源塑胶有限公司 Medical thin film material

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7082520B2 (en) 2018-05-07 2022-06-08 ナガセケムテックス株式会社 Reactive composition
CN111576042A (en) * 2020-04-30 2020-08-25 王洛 Environment-friendly antibacterial plastic bag
CN111574730A (en) * 2020-06-09 2020-08-25 江苏工程职业技术学院 Preparation method of polyepoxypropionic acid hydrogel

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Application publication date: 20181218