CN109010913B - Preparation method of biological glass bone repair composite material - Google Patents
Preparation method of biological glass bone repair composite material Download PDFInfo
- Publication number
- CN109010913B CN109010913B CN201811046799.2A CN201811046799A CN109010913B CN 109010913 B CN109010913 B CN 109010913B CN 201811046799 A CN201811046799 A CN 201811046799A CN 109010913 B CN109010913 B CN 109010913B
- Authority
- CN
- China
- Prior art keywords
- parts
- bone repair
- polyurethane foam
- slurry
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a preparation method of a bioglass bone repair composite material, and belongs to the technical field of bone repair materials. The components in the bioactive glass material can exchange or react with the components in the organism to finally generate a substance compatible with the organism to form a part of a new skeleton, the biological glass based on boron has better plasticity and biodegradability, and the chitosan is used for coating the active glass to assist the pearl protein to regulate CaCO3The deposition speed and the surface morphology are regulated, the combination condition with calcium ions is regulated, the nucleation of calcium carbonate crystals is accelerated, the nucleation and the directional growth of hydroxyapatite crystals on the surface of the material are induced, and a natural bone lamellar film is constructed, so that the adhesion and the spreading of bone mesenchymal stem cells are promoted, the adhesion and the proliferation of the cells are remarkably promoted, the activity of alkaline phosphatase is promoted, the differentiation of osteoblasts is induced, the formation of mineralized nodules is promoted, the differentiation of osteoclasts and the absorption of bone tissues are inhibited, and the bone repair is effectively promoted.
Description
Technical Field
The invention relates to a preparation method of a bioglass bone repair composite material, and belongs to the technical field of bone repair materials.
Background
Biomedical materials, also known as biomaterials, are mainly new high-tech materials that interact with biological systems to repair, treat, synthesize, or replace damaged tissues and organs with minimal adverse effects on human tissues and blood. The biomedical material comprises biomedical polymer materials such as bioglass ceramics, biological coatings, biological calcium phosphate ceramics, bioglass and the like. Since the preparation of bioactive glass, the bioactive glass is used as a bone repair substitute material for repairing, regenerating and replacing organs such as bones, teeth and the like. The bioactive glass has the capacity of inducing the proliferation and the differentiation of osteocytes and promoting the growth of the osteocytes, and can strongly connect hard tissues and soft tissues of a human body. The bioglass has a specific chemical composition, and inorganic ions (such as silicon, phosphorus, calcium, sodium and the like) dissolved out of the bioglass can promote the expression of genes and the differentiation of cells to an osteogenic direction, promote the proliferation and differentiation of osteoblasts, further form firm chemical bonding with bone tissues and have good bone repair performance.
Bioglass is an important branch of biomedical materials, mainly composed of silicate glass materials, and the main component is SiO2And CaO. Has good biocompatibility and no toxic or side effect, and forms new bone tissues through direct chemical bonding and biodegradation with a human body. One of the most important applications of bioglass is in bone repair. The bioglass has the advantages of good biocompatibility, nontoxicity, higher bioactivity and the like, so that the bioglass is widely applied to bone repair. The bioglass can generate hydroxyapatite which is the same as the bone and can directly participate in the process of repairing the bone of a human body and induce the generation of bone tissues in a simulated body fluid, so that the bioglass can be used for repairing the bone. The bioglass can also be used in the treatment of diseases such as teeth, middle ear bones and the like.
The bioglass prepared by the sol-gel method has larger specific surface area and pore volume, is beneficial to the deposition of hydroxyapatite of similar bones, has strong biological mineralization function and good biological activity, promotes the adhesion, proliferation and growth of osteoblasts on the surface of the bioglass, and meets the basic conditions for bone repair materials. With the continuous research and modification of the bioglass by researchers, the bioglass is widely applied to tissue engineering and meets various clinical requirements.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: aiming at the problem of poor compatibility of the existing bone repair material and bone tissues, a preparation method of a bioglass bone repair composite material is provided.
In order to solve the technical problems, the invention adopts the technical scheme that:
(1) adding ethyl orthosilicate, boric acid, triethyl phosphate, calcium nitrate, magnesium nitrate and strontium nitrate into a polyvinyl alcohol solution with the mass fraction of 2% and uniformly stirring to obtain a suspended slurry;
(2) immersing polyurethane foam cut into 1cm multiplied by 1cm into the slurry hanging liquid and repeatedly pressing until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH value to 12.0-12.5, standing, taking out the polyurethane foam and drying to obtain the slurry hanging treated polyurethane foam;
(3) placing the slurry-coated polyurethane foam into a muffle furnace for calcining, cooling to room temperature, and discharging to obtain bioactive glass;
(4) adding pearl powder into an ethylenediaminetetraacetic acid aqueous solution with the mass fraction of 2%, stirring and mixing, then carrying out centrifugal separation for 10-15 min at a speed of 6000-8000 r/min, removing precipitates, and drying to obtain pearl protein;
(5) adding trisodium phosphate, calcium chloride and pearl protein into a chitosan solution with the mass fraction of 1%, uniformly stirring, adding bioactive glass, soaking for 10-20 h, taking out the bioactive glass, and drying to constant weight to obtain the biological glass bone repair composite material.
The molar parts of the tetraethoxysilane, the boric acid, the triethyl phosphate, the calcium nitrate, the magnesium nitrate and the strontium nitrate in the step (1) are 18-24 parts of tetraethoxysilane, 36-48 parts of boric acid, 8-12 parts of triethyl phosphate, 24-36 parts of calcium nitrate, 8-12 parts of magnesium nitrate and 3-6 parts of strontium nitrate.
And (3) heating to 350-400 ℃ at a speed of 2 ℃/min in the calcining process, carrying out heat preservation reaction for 1-2 h, heating to 400-600 ℃ at a speed of 5 ℃/min, and carrying out heat preservation sintering for 3-5 h.
The mass ratio of the pearl powder to the ethylene diamine tetraacetic acid aqueous solution in the step (4) is 1: 25-1: 60.
10-15 parts of trisodium phosphate, 10-15 parts of calcium chloride, 3-5 parts of pearl protein and 200-300 parts of a chitosan solution with the mass fraction of 1%.
And (6) soaking at 50-60 ℃.
Compared with other methods, the method has the beneficial technical effects that:
(1) the components in the bioactive glass material can exchange or react with the components in the organism to form firm chemical bond combination, and finally generate the bioactive glass material compatible with the organismThe substance forms a part of the new bone, the doped boron element is one of trace elements required for maintaining the health of the bone and the normal metabolism of calcium, phosphorus and magnesium, the boron-based bioglass has better plasticity and biodegradability, and the chitosan is used for coating the active glass to assist the pearl protein to regulate CaCO3The deposition speed and the surface morphology are regulated, the combination condition with calcium ions is regulated, the nucleation of calcium carbonate crystals is accelerated, hydroxyapatite crystals are induced to nucleate and directionally grow on the surface of the material, and a natural bone lamellar film is constructed, so that the adhesion and the spreading of bone mesenchymal stem cells are promoted, the adhesion and the proliferation of the cells are remarkably promoted, the activity of alkaline phosphatase is promoted, the differentiation of osteoblasts is induced, the formation of mineralized nodules is promoted, the differentiation of osteoclasts and the absorption of bone tissues are inhibited, and the bone repair is effectively promoted;
(2) the bioglass bone repair composite material can induce the differentiation of bone marrow mesenchymal stem cells to osteoblasts, and the prepared composite material has high mechanical strength, high matching degree of elastic modulus and human skeleton, high cell activity, good biocompatibility with a human body, good bone induction activity, capability of quickly completing the repair and functional reconstruction of bone tissues, good biodegradability and high popularization and use value.
Detailed Description
Adding 0.18-0.24 mol of ethyl orthosilicate, 0.36-0.48 mol of boric acid, 0.08-0.12 mol of triethyl phosphate, 0.24-0.36 mol of calcium nitrate, 0.08-0.12 mol of magnesium nitrate and 0.03-0.06 mol of strontium nitrate into 2-3L of a polyvinyl alcohol solution with the mass fraction of 2% and stirring at 300-400 r/min for 20-30 min to obtain a slurry, immersing polyurethane foam cut into 1cm x 1cm into the slurry and repeatedly pressing for 2-5 times until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH to 12.0-12.5, standing for 1-2 h, taking out the polyurethane foam, drying in a drying box at 105-120 ℃ for 3-5 h to obtain slurry-treated polyurethane foam, putting the slurry-treated polyurethane foam into a muffle furnace, heating to 350-400 ℃ at 2 ℃/min, carrying out heat preservation reaction for 1-2 h, then heating to 400 ℃ at 5-5 ℃/min, carrying out heat preservation reaction for 1-5 h, cooling to room temperature, discharging to obtain bioactive glass, adding 10-20 g of pearl powder into 500-600 g of an ethylene diamine tetraacetic acid aqueous solution with the mass fraction of 2%, stirring at 40-50 ℃ for 1-2 h at 300-400 r/min, then performing centrifugal separation at 6000-8000 r/min for 10-15 min, removing precipitates, drying to obtain pearl protein, adding 10-15 g of trisodium phosphate, 10-15 g of calcium chloride and 3-5 g of pearl protein into 200-300 g of a chitosan solution with the mass fraction of 1%, stirring at 300-400 r/min for 20-30 min, adding the bioactive glass, soaking at 50-60 ℃ for 10-20 h, taking out the bioactive glass, and drying at 50-60 ℃ to constant weight to obtain the bioactive glass bone repair composite material.
Taking 0.18mol of ethyl orthosilicate, 0.36mol of boric acid, 0.08mol of triethyl phosphate, 0.24mol of calcium nitrate, 0.08mol of magnesium nitrate and 0.03mol of strontium nitrate, adding 2L of polyvinyl alcohol solution with the mass fraction of 2% and stirring for 20min at the speed of 300r/min to obtain a slurry, immersing polyurethane foam cut into 1cm multiplied by 1cm into the slurry and repeatedly pressing for 2 times until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH value to 12.0, standing for 1h, taking out the polyurethane foam, placing the polyurethane foam in a drying oven to dry for 3h at the temperature of 105 ℃ to obtain slurry-treated polyurethane foam, putting the slurry-treated polyurethane foam into a muffle furnace, heating to 350 ℃ at the speed of 2 ℃/min, carrying out heat preservation reaction for 1h, heating to 400 ℃ at the speed of 5 ℃/min, carrying out heat preservation sintering for 3h, cooling to room temperature, discharging to obtain bioactive glass, adding 10g of the bioactive glass into 500g of ethylene diamine tetraacetic acid aqueous solution with the mass fraction of 2%, stirring at 40 ℃ for 1h at 300r/min, centrifuging at 6000r/min for 10min, removing precipitate, drying to obtain pearl protein, adding 10g of trisodium phosphate, 10g of calcium chloride and 3g of pearl protein into 200g of chitosan solution with the mass fraction of 1%, stirring at 300r/min for 20min, adding bioactive glass, soaking at 50 ℃ for 10h, taking out the bioactive glass, and drying at 50 ℃ to constant weight to obtain the biological glass bone repair composite material.
Taking 0.21mol of ethyl orthosilicate, 0.42mol of boric acid, 0.10mol of triethyl phosphate, 0.30mol of calcium nitrate, 0.10mol of magnesium nitrate and 0.05mol of strontium nitrate, adding 2L of polyvinyl alcohol solution with the mass fraction of 2% and stirring for 25min at the speed of 350r/min to obtain suspended slurry, immersing polyurethane foam cut into 1cm multiplied by 1cm into the suspended slurry and repeatedly pressing for 3 times until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH value to 12.2, standing for 1h, taking out the polyurethane foam, placing the polyurethane foam in a drying oven to dry for 4h at the temperature of 115 ℃ to obtain suspended slurry treated polyurethane foam, putting the suspended slurry treated polyurethane foam into a muffle furnace, heating to 375 ℃ at the speed of 2 ℃/min, carrying out heat preservation reaction for 1h, heating to 500 ℃ at the speed of 5 ℃/min, carrying out heat preservation sintering for 4h, cooling to room temperature and then discharging to obtain bioactive glass, taking 15g of the bioactive glass, adding 550g of ethylene diamine tetraacetic acid aqueous solution with the mass fraction of 2%, stirring at 45 ℃ for 1h at 350r/min, centrifuging at 7000r/min for 12min, removing precipitate, drying to obtain pearl protein, adding 12g of trisodium phosphate, 12g of calcium chloride and 4g of pearl protein into 250g of chitosan solution with the mass fraction of 1%, stirring at 350r/min for 25min, adding bioactive glass, soaking at 55 ℃ for 15h, taking out the bioactive glass, and drying at 55 ℃ to constant weight to obtain the bioglass bone repair composite material.
Taking 0.24mol of ethyl orthosilicate, 0.48mol of boric acid, 0.12mol of triethyl phosphate, 0.36mol of calcium nitrate, 0.12mol of magnesium nitrate and 0.06mol of strontium nitrate, adding 3L of polyvinyl alcohol solution with the mass fraction of 2% and stirring for 30min at the speed of 400r/min to obtain a slurry, immersing polyurethane foam cut into 1cm multiplied by 1cm into the slurry and repeatedly pressing for 5 times until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH value to 12.5, standing for 2h, taking out the polyurethane foam, placing the polyurethane foam in a drying oven to dry for 5h at the temperature of 120 ℃ to obtain slurry-treated polyurethane foam, putting the slurry-treated polyurethane foam into a muffle furnace, heating to 400 ℃ at the speed of 2 ℃/min, carrying out heat preservation reaction for 2h, heating to 600 ℃ at the speed of 5 ℃/min, carrying out heat preservation sintering for 5h, cooling to room temperature and then discharging to obtain bioactive glass, adding 20g of the bioactive glass into 600g of ethylene diamine tetraacetic acid aqueous solution with the mass fraction of 2%, stirring at 50 ℃ for 2h at 400r/min, centrifuging at 8000r/min for 15min, removing precipitate, drying to obtain pearl protein, adding 15g of trisodium phosphate, 15g of calcium chloride and 5g of pearl protein into 300g of chitosan solution with the mass fraction of 1%, stirring at 400r/min for 30min, adding bioactive glass, soaking at 60 ℃ for 20h, taking out the bioactive glass, and drying at 60 ℃ to constant weight to obtain the bioactive glass bone repair composite material.
Comparative example: a bioglass bone repair composite material produced by Dongguan company.
Experiments show that: the particle size range of the prepared bioactive glass is 65-160 nm, and the shell thickness range is 10-35 nm. Nitrogen adsorption-desorption studies showed: the specific surface area of the prepared bioactive glass is 33.89-50.16 m2The pore volume is 0.072-0.129 cm3(ii) in terms of/g. Wherein, according to the following ratio of TEOS: PAA = 0.9: the specific surface area of the sample prepared at 0.2 mass ratio was 50.16m2Per g, pore volume of 0.129cm3(ii) in terms of/g. Selecting TEOS: PAA = 0.9: 0.2 bioactive glass to perform in vitro bioactivity studies. The hydroxyapatite deposited on the outer surface of the obtained product has better biological activity. The in vitro bioactivity test shows that: along with the prolonging of the time of soaking the simulated body fluid, the surface of the sample is obviously roughened, the crystallinity is obviously improved, and the hydroxyapatite has strong hydroxyapatite forming capability and better biological activity.
Claims (3)
1. The preparation method of the biological glass bone repair composite material is characterized by comprising the following specific steps:
(1) adding ethyl orthosilicate, boric acid, triethyl phosphate, calcium nitrate, magnesium nitrate and strontium nitrate into a polyvinyl alcohol solution with the mass fraction of 2% and uniformly stirring to obtain a suspended slurry; the molar parts of the tetraethoxysilane, the boric acid, the triethyl phosphate, the calcium nitrate, the magnesium nitrate and the strontium nitrate are 18-24 parts of tetraethoxysilane, 36-48 parts of boric acid, 8-12 parts of triethyl phosphate, 24-36 parts of calcium nitrate, 8-12 parts of magnesium nitrate and 3-6 parts of strontium nitrate;
(2) immersing polyurethane foam cut into 1cm multiplied by 1cm into the slurry hanging liquid and repeatedly pressing until the polyurethane foam is completely soaked by the slurry, adding ammonia water to adjust the pH value to 12.0-12.5, standing, taking out the polyurethane foam and drying to obtain the slurry hanging treated polyurethane foam;
(3) placing the slurry-coated polyurethane foam into a muffle furnace for calcining, cooling to room temperature, and discharging to obtain bioactive glass;
(4) adding pearl powder into an ethylenediaminetetraacetic acid aqueous solution with the mass fraction of 2%, stirring and mixing, then carrying out centrifugal separation for 10-15 min at a speed of 6000-8000 r/min, removing precipitates, and drying to obtain pearl protein; the mass ratio of the pearl powder to the ethylene diamine tetraacetic acid aqueous solution is 1: 25-1: 60, adding a solvent to the mixture;
(5) adding trisodium phosphate, calcium chloride and pearl protein into a chitosan solution with the mass fraction of 1%, uniformly stirring, adding bioactive glass, soaking for 10-20 h, taking out the bioactive glass, and drying to constant weight to obtain a bioglass bone repair composite material; the weight parts of the trisodium phosphate, the calcium chloride, the pearl protein and the chitosan solution are 10-15 parts of trisodium phosphate, 10-15 parts of calcium chloride, 3-5 parts of pearl protein and 200-300 parts of chitosan solution with the mass fraction of 1%.
2. The preparation method of the bioglass bone repair composite material as claimed in claim 1, wherein the calcination process in the step (3) is heating to 350-400 ℃ at a speed of 2 ℃/min, reacting for 1-2 h under heat preservation, heating to 400-600 ℃ at a speed of 5 ℃/min, and sintering for 3-5 h under heat preservation.
3. The method for preparing a bioglass bone repair composite material as claimed in claim 1, wherein the soaking temperature in step (5) is 50-60 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811046799.2A CN109010913B (en) | 2018-09-08 | 2018-09-08 | Preparation method of biological glass bone repair composite material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811046799.2A CN109010913B (en) | 2018-09-08 | 2018-09-08 | Preparation method of biological glass bone repair composite material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109010913A CN109010913A (en) | 2018-12-18 |
| CN109010913B true CN109010913B (en) | 2021-07-23 |
Family
ID=64624298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811046799.2A Active CN109010913B (en) | 2018-09-08 | 2018-09-08 | Preparation method of biological glass bone repair composite material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010913B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110776315B (en) * | 2019-11-01 | 2022-03-15 | 深圳先进技术研究院 | Magnesium strontium-silicon phosphate material, preparation method thereof and structure-controllable porous bone repair composite scaffold material containing magnesium strontium-silicon phosphate material |
| CN113754556B (en) * | 2021-09-29 | 2022-10-25 | 中国科学院过程工程研究所 | Glass based on amino acid, preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642589A (en) * | 2009-09-11 | 2010-02-10 | 华南理工大学 | Preparation method of biological active glass/chitosan composite porous support material |
| FR3006195B1 (en) * | 2013-06-03 | 2018-03-02 | Centre National De La Recherche Scientifique | IMPLANT WITH CONTROLLED POROSITY |
| CN105541086A (en) * | 2015-11-09 | 2016-05-04 | 陕西盛迈石油有限公司 | Method for preparing porous biological glass scaffold |
| CN108066817A (en) * | 2017-12-06 | 2018-05-25 | 常州琨瑶纺织品有限公司 | A kind of nano bone repair material and preparation method thereof |
-
2018
- 2018-09-08 CN CN201811046799.2A patent/CN109010913B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109010913A (en) | 2018-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105536070B (en) | A kind of compound bone cement and preparation method | |
| Varma et al. | Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method | |
| CN109010913B (en) | Preparation method of biological glass bone repair composite material | |
| CN106830899B (en) | Composite ceramic material and preparation method and application thereof | |
| CN104030718A (en) | Trace element-doped porous calcium carbonate ceramic, and preparation method and application thereof | |
| CN108404203B (en) | Preparation method of reduced graphene oxide/biological glass nanofiber scaffold | |
| CN107141022A (en) | A kind of whitlockite coating built in calcium phosphate bioceramic matrix surface and preparation method thereof | |
| CN101401964A (en) | Organic-inorganic compound bone restoration bioactive material | |
| CN114452439B (en) | Hydroxyapatite/whitlockite bioactive ceramic scaffold consisting of bionic natural bone minerals and preparation method thereof | |
| CN102229494B (en) | Preparation method for macroporous hydroxyapatite ceramic | |
| CN108569896A (en) | A kind of calcium polyphosphate/wollastonite composite biological ceramic material and preparation method thereof | |
| Essien et al. | Microwave energy-assisted formation of bioactive CaO–MgO–SiO 2 ternary glass from bio-wastes | |
| CN108395236A (en) | A kind of preparation method and applications of bioceramic | |
| CN107661540B (en) | Method for preparing high-strength hydroxyapatite-chitosan-silicon dioxide hybrid scaffold by using 3D printing | |
| CN110507547B (en) | Composite active marrow preservation material based on bioactive glass/chitosan and preparation method and application thereof | |
| CN108404206A (en) | A kind of preparation method of bone renovating material | |
| CN112919888B (en) | Alumina ceramic with HA-coated surface and preparation method thereof | |
| CN109125804A (en) | A kind of solidify liquid and the preparation method and application thereof suitable for calcium orthophosphate base bone cement | |
| CN108607119B (en) | Calcium polyphosphate surface polydopamine modified composite biological ceramic and preparation method thereof | |
| CN107041970A (en) | A kind of compound bone cement of high inorganic component and its preparation method and application | |
| CN105833345A (en) | Porous calcium phosphate/gelatin composite scaffold for bone tissue engineering and preparation method of porous calcium phosphate/gelatin composite scaffold | |
| CN108517515A (en) | The method for preparing Mg alloy surface zinc doping calcium phosphor coating using one step hydro thermal method | |
| CN108686263B (en) | Method for preparing HA degradable coating on surface of magnesium alloy | |
| AU2020244514B2 (en) | Tricalcium phosphate material doped with Mg and Zn and preparation method thereof, and 3D printing ceramic slurry and preparation method thereof | |
| CN110468399A (en) | A kind of preparation method of medical pure titanium surface strontium calcium phosphate chemical composition coating |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210622 Address after: Room 1401, block a, building 1, Aojing Health Technology Industrial Park, 2178 Chongwen street, Fangzi District, Weifang City, Shandong Province, 261200 Applicant after: Weifang Aojing Medical Research Co.,Ltd. Address before: 528000 203x, 2nd floor, building 1, Fengshou street, Chaoan South Road, zumiao street, Chancheng District, Foshan City, Guangdong Province Applicant before: FOSHAN SENANG BIOTECHNOLOGY Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |