CN109010320B - Double-release calcium polycarbophil granules, preparation method and application thereof in livestock and poultry - Google Patents
Double-release calcium polycarbophil granules, preparation method and application thereof in livestock and poultry Download PDFInfo
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Abstract
The invention relates to a double-release calcium polycarbophil granule, a preparation method thereof and application thereof in livestock and poultry, belonging to the field of veterinary drugs and premixes. The double-release calcium polycarbophil granule is prepared by spraying a quick-release outer layer on a slow-release core layer, granulating, spraying a gastric-soluble coating material, and drying. The calcium polycarbophil granules can be quickly released in the stomach and slowly released after reaching the intestinal tract, so that the retention time of the calcium polycarbophil in the intestinal tract is prolonged, and the antidiarrheal effect is obvious. The calcium polycarbophil is not absorbed in intestinal tracts and has no residue, and can replace antibiotics in livestock and poultry breeding.
Description
Technical Field
The invention belongs to the field of feed additives, and particularly relates to a double-release calcium polycarbophil granule, a preparation method thereof and application thereof in livestock and poultry, belonging to the field of veterinary drugs and premixes.
Background
Polycarbophil (Calcium polycarbophil) was originally developed by yapei incorporated in the united states for treating Irritable Bowel Syndrome (IBS), and has been widely used in europe and the united states and japan for relieving IBS and constipation symptoms due to various causes, and the drug has been approved for sale in 2011 in domestic.
The active component of the polycarbophil calcium is diethylene glycol crosslinked acrylic acid copolymer calcium salt, resin with extremely high hydrophilicity and extremely high water absorption performance is resin with a molecular formula of (C6H6CaO4) a- (C6H10O2) b. The calcium polycarbophil has very unique biochemical properties, calcium in the calcium polycarbophil can be rapidly removed in an acid environment to form the calcium polycarbophil, the calcium polycarbophil can absorb water 10 times of the weight of the calcium polycarbophil under the acid condition, and meanwhile, when the pH value is more than 4, the calcium polycarbophil can swell and absorb more water in a neutral or weakly alkaline environment, and the maximum calcium polycarbophil can reach 60-100 times. Therefore, after the calcium polycarbophil is orally taken into the stomach by organisms, the calcium is removed in a gastric acid environment to form the polycarbophil; animal experiments show that the decalcification rate in the stomach of a rat can reach 70 percent within 30 minutes after the rat takes the medicine. Because the stomach is in an acidic environment, a small amount of water can be absorbed, and after the water enters the intestinal tract, the water absorption of the polycarbophil is enhanced due to the increase of the pH value, so that more water in the intestinal tract can be absorbed and locked.
The mechanism of action of calcium polycarbophil in the intestinal tract mainly has two functions of water retention and digestive tract content transportation and regulation. Therefore, when the calcium polycarbophil is used by organisms, the diarrhea can be treated, constipation can not be induced, and the constipation organisms can increase defecation without causing diarrhea, which is incomparable with other medicines.
The polycarbophil calcium is a high molecular substance and cannot be absorbed in the intestinal tract of an organism, after 14C isotope labeled polycarbophil calcium is orally taken by rats and dogs, the residue of each part of the digestive tract is analyzed and found not to be absorbed, the polycarbophil calcium residue is not found in urine, and all the polycarbophil is discharged out of the body through excrement, so that the polycarbophil calcium cannot be absorbed by the digestive tract and metabolized by microorganisms in the intestinal tract, and finally, all the polycarbophil calcium is discharged out of the body through the excrement, and no residue exists on the organism.
At present, livestock and poultry breeding in China is influenced by environmental protection, scales are more and more concentrated, scattered breeding and small-scale breeding farms are gradually replaced by large-scale concentrated breeding farms because the environment can not reach the standard, and large-scale concentrated breeding has great advantages in the aspects of improving the breeding efficiency, reducing the breeding pollution and reducing the breeding cost, but the main problem brought by the large-scale concentrated breeding farms is cross infection, and most commonly animal diarrhea. Generally, diarrhea is caused by various causes, so great difficulty is brought to prevention and treatment, and at present, drugs for treating diarrhea mainly comprise three types, namely antibiotics, microecologics and gastrointestinal mucosa protective agents, wherein the antibiotics have the best effect, but are gradually limited to be used in the situation of large domestic resistance-reducing environments; the microecological preparation and the common gastrointestinal mucosa protective agent are used for slowly improving the condition of the gastrointestinal tract, can not solve most of diarrhea problems, and have slow effect, strong uncertainty of effect and poor actual use effect.
Many drugs for treating diarrhea are available in domestic and foreign markets, but no drug which is high in efficiency, wide in adaptability and small in toxic and side effects is available except antibiotics. Under the large environment that food health is concerned in the society at present, the development of a non-antibiotic veterinary intestinal tract regulation medicament with high efficiency, low toxicity (no toxicity) and broad spectrum is a critical urgency for ensuring food safety. The application of calcium polycarbophil in human is reported, but the application of calcium polycarbophil in livestock and poultry breeding is not reported.
Disclosure of Invention
The invention aims to provide a double-release type polycarbophil calcium granule, which is rapidly disintegrated after an outer layer reaches the stomach, a quick-release part rapidly releases a medicament to reach an effective blood concentration, a slow-release core layer slowly releases the medicament to maintain the effective blood concentration, the timely and effective prevention and treatment of diseases are realized, and the defects in the prior art are overcome.
The invention also aims to provide a preparation method of the double-release type calcium polycarbophil granules and application of the double-release type calcium polycarbophil granules in livestock and poultry.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the double-release type calcium polycarbophil granule consists of a slow release core layer, a quick release outer layer and a gastric coating material layer, wherein the mass percentages of the layers are as follows: 50-70% of slow-release core layer, 10-30% of quick-release outer layer and 10-20% of gastric-soluble coating material layer, wherein
The slow release core layer is processed from the following components in percentage by mass:
calcium polycarbophil 2-10%
Gluten powder 20-50%
15-30% of hydroxypropyl cellulose
10 to 40 percent of plasticizer
1 to 3 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
40-80% of calcium polycarbophil
3 to 8 percent of propylene glycol
20 to 50 percent of binder
5 to 20 percent of disintegrating agent
The balance being pure water.
The wheat gluten is also called active gluten flour and wheat gluten protein, and is natural protein extracted from wheat (flour). The main components of the glutenin gliadin are glutenin and gliadin, glutenin molecules are fibrous and contain more beta-folding structures; the prolamin molecules are connected by virtue of hydrogen bonds, hydrophobic bonds and intramolecular disulfide bonds to form a compact three-dimensional structure. The use of wheat gluten together with hydroxypropylcellulose increases the porosity of the particulate microspheres and delays the drug release time. In addition, the wheat gluten can absorb 2 times of water when meeting water, and the water absorption in intestinal tracts can be synergistically improved by using the wheat gluten and the calcium polycarbophil simultaneously, so that the diarrhea can be effectively prevented and treated.
Because the calcium polycarbophil and the hydroxypropyl cellulose are mutually incompatible systems, the prepared core layer is a simple physical blending system, is in a thermodynamically unstable state and is easy to separate after long-term storage. The stability of the slow release core layer is improved by adding a proper amount of surfactant, span and poloxamer are both nonionic surfactants, and the slow release core layer is added to form a stable core-shell structure under vigorous stirring, wherein the polycarbophil calcium forms a core of a system, the surfactant forms an interface film of the system, and the pore-forming agent hydroxypropyl cellulose forms a shell of the system, so that the interface energy of the system is reduced, the compatibility and the stability of the system are improved, meanwhile, the dissolution rate of the polycarbophil calcium is further improved through the synergistic effect of the hydroxypropyl cellulose and the surfactant, and the effect is better.
Preferably, the granule consists of a slow release core layer, a quick release outer layer and a gastric coating material layer, and the mass percentages of the layers are as follows: 55% of a slow release core layer, 30% of a quick release outer layer and 15% of a gastric coating material layer, wherein
The slow release core layer is processed from the following components in percentage by mass:
10 percent of calcium polycarbophil
Gluten powder 20%
Hydroxypropyl cellulose 20%
15 percent of plasticizer
2 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
50 percent of polycarbophil calcium
Propylene glycol 5%
20 percent of binder
8 percent of disintegrating agent
The balance being pure water.
Preferably, the binder is at least one of corn starch, white carbon black and dextrin.
Preferably, the disintegrant is at least one of croscarmellose sodium, crospovidone, low-substituted hydroxypropylcellulose and sodium carboxymethyl starch.
Preferably, the plasticizer is at least one of polyethylene, ethyl cellulose, acrylic resin, polymethyl methacrylate, and silicone rubber.
Preferably, the surfactant is span and/or poloxamer.
The gastric coating material is at least one of hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinyl alcohol, acrylic resin VI, polyvinylpyrrolidone, Eudragit E, gastric Opadry coating powder and gastric easy-release coating powder.
A preparation method of double-release calcium polycarbophil granules comprises the following steps:
first, a sustained-release core layer is prepared
Uniformly mixing the calcium polycarbophil, the wheat gluten, the hydroxypropyl cellulose, the plasticizer and the surfactant according to the prescription amount, granulating in a one-step granulator in one step, drying on a fluidized bed to obtain dry granules, and sieving by a 20-60-mesh sieve;
second, preparing a quick-release outer layer
Uniformly mixing the calcium polycarbophil, the propylene glycol, the disintegrant material and the binder according to the prescription amount, adding pure water, and uniformly mixing to obtain a slurry material;
thirdly, granulating
Spraying the slurry material obtained in the second step on the dry particles obtained in the first step in a granulator, and sieving;
fourthly, coating
And (3) coating the dry particles obtained in the third step with a gastric coating material by spraying on a one-step granulator, drying, and sieving with a 20-mesh sieve to obtain the calcium polycarbophil particles.
The double-release calcium polycarbophil granules can be used for preparing medicines for preventing and treating livestock and poultry diarrhea diseases.
The polycarbophil calcium premix obtained by the invention can be applied to the feeding of economic animals, including chickens, ducks, geese, pigs, cattle, sheep, rabbits and the like.
The dosage of the polycarbophil calcium premix obtained by the invention for treating livestock and poultry is different according to animals, and the daily dosage of each head (only) is between 1 and 20 g. The specific recommended daily dose is: 1-15g of pig, 5-20g of cattle, 2-10g of sheep, 0.5-3g of rabbit, 0.1-3g of chicken, 0.1-3g of duck and 0.2-4g of goose, and has obvious effect of treating diarrhea.
The calcium polycarbophil granules can also be added into feed for preparing the feed for promoting the growth of livestock and poultry, such as: the premix provided by the invention is also applied to preparing feeds such as batch, granular feed and the like.
The invention has the beneficial effects that:
1. the double-release type polycarbophil calcium granules provided by the invention can realize double-release behavior, the outer layer reaches the stomach and is rapidly disintegrated, the quick-release part rapidly releases the medicine to reach the effective blood concentration, and the slow-release layer slowly releases the medicine to maintain the effective blood concentration, so that the timely and effective prevention and treatment of diseases are realized. The medicine is more convenient and feasible to use, the administration times can be reduced, and the medication compliance is improved.
2. The physical stability of the calcium polycarbophil particle core layer is improved through the synergistic effect of the surfactant, and the long-term storage and transportation are facilitated.
3. The double-release calcium polycarbophil granule provided by the invention has the advantages that the wheat gluten is added into the core layer, so that the porosity of the microsphere is increased, the drug release time is delayed, the water absorption in intestinal tracts can be improved by cooperating with calcium polycarbophil, and the effect of treating water diarrhea is obvious.
4. According to the invention, the calcium polycarbophil is used for regulating animal intestinal tracts and treating animal diarrhea, and animal experiments show that the diarrhea of animals can be obviously improved and the effect is quick under the condition that the addition amount is 1-20g per head (only) per day according to different target animals.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
In the following examples, the polycarbophil calcium used was purchased from Zhejiang Tuopu pharmaceutical Co., Ltd, and the nosiheptide premix was purchased from Zhejiang Huoneng Biometrics Ltd. All other auxiliary materials used were purchased from market suppliers.
Example 1: preparation of double-release calcium polycarbophil granules
A double-release calcium polycarbophil granule comprises a slow release core layer 50 wt%, a quick release outer layer 30 wt% and a gastric coating material layer 20 wt%, wherein the coating material layer comprises
The slow release core layer is processed from the following components in percentage by mass:
10 percent of calcium polycarbophil
Gluten powder 20%
Hydroxypropyl cellulose 30%
20 percent of plasticizer
2 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
50 percent of polycarbophil calcium
Propylene glycol 5%
20 percent of binder
8 percent of disintegrating agent
The balance being pure water.
In the invention, the binder is white carbon black, the disintegrant is sodium carboxymethyl starch, the plasticizer is polyethylene, and the surfactant is span.
In the invention, the preparation method of the double-release type calcium polycarbophil granules comprises the following steps:
first, a sustained-release core layer is prepared
Uniformly mixing the calcium polycarbophil, the wheat gluten, the hydroxypropyl cellulose, the plasticizer and the surfactant according to the prescription amount, granulating in a one-step granulator in one step, drying on a fluidized bed to obtain dry granules, and sieving by a 20-60-mesh sieve;
second, preparing a quick-release outer layer
Uniformly mixing the calcium polycarbophil, the propylene glycol, the disintegrant material and the binder according to the prescription amount, adding pure water, and uniformly mixing to obtain a slurry material;
thirdly, granulating
Spraying the slurry material obtained in the second step on the dry particles obtained in the first step in a granulator, and sieving;
fourthly, coating
And (3) coating the dry particles obtained in the third step with a gastric coating material by spraying on a one-step granulator, drying, and sieving with a 20-mesh sieve to obtain the calcium polycarbophil particles.
Example 2: preparation of double-release calcium polycarbophil granules
A double-release calcium polycarbophil granule comprises a slow release core layer 60 wt%, a quick release outer layer 20 wt% and a gastric coating material layer 20 wt%.
The slow release core layer is processed from the following components in percentage by mass:
calcium polycarbophil 8%
28 percent of vital gluten
Hydroxypropyl cellulose 22%
Plasticizer 10%
2 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
50 percent of polycarbophil calcium
Propylene glycol 5%
20 percent of binder
8 percent of disintegrating agent
The balance being pure water.
In the invention, the binder is dextrin, the disintegrating agent is low-substituted hydroxypropyl cellulose, the plasticizer is acrylic resin, and the surfactant is poloxamer.
In the invention, the preparation method of the double-release type calcium polycarbophil granules comprises the following steps:
first, a sustained-release core layer is prepared
Uniformly mixing the calcium polycarbophil, the wheat gluten, the hydroxypropyl cellulose, the plasticizer and the surfactant according to the prescription amount, granulating in a one-step granulator in one step, drying on a fluidized bed to obtain dry granules, and sieving by a 20-60-mesh sieve;
second, preparing a quick-release outer layer
Uniformly mixing the calcium polycarbophil, the propylene glycol, the disintegrant material and the binder according to the prescription amount, adding pure water, and uniformly mixing to obtain a slurry material;
thirdly, granulating
Spraying the slurry material obtained in the second step on the dry particles obtained in the first step in a granulator, and sieving;
fourthly, coating
And (3) coating the dry particles obtained in the third step with a gastric coating material by spraying on a one-step granulator, drying, and sieving with a 20-mesh sieve to obtain the calcium polycarbophil particles.
Example 3: preparation of double-release calcium polycarbophil granules
A double-release calcium polycarbophil granule comprises a slow release core layer 70 wt%, a quick release outer layer 10 wt% and a gastric coating material layer 20 wt%.
The slow release core layer is processed from the following components in percentage by mass:
10 percent of calcium polycarbophil
30 percent of vital gluten
Hydroxypropyl cellulose 15%
15 percent of plasticizer
2 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
calcium polycarbophil 60%
Propylene glycol 5%
20 percent of binder
8 percent of disintegrating agent
The balance being pure water.
In the invention, the binder is corn starch, the disintegrant is sodium carboxymethyl starch, the plasticizer is silicon rubber, and the surfactant is poloxamer.
In the invention, the preparation method of the double-release type calcium polycarbophil granules comprises the following steps:
first, a sustained-release core layer is prepared
Uniformly mixing the calcium polycarbophil, the wheat gluten, the hydroxypropyl cellulose, the plasticizer and the surfactant according to the prescription amount, granulating in a one-step granulator in one step, drying on a fluidized bed to obtain dry granules, and sieving by a 20-60-mesh sieve;
second, preparing a quick-release outer layer
Uniformly mixing the calcium polycarbophil, the propylene glycol, the disintegrant material and the binder according to the prescription amount, adding pure water, and uniformly mixing to obtain a slurry material;
thirdly, granulating
Spraying the slurry material obtained in the second step on the dry particles obtained in the first step in a granulator, and sieving;
fourthly, coating
And (3) coating the dry particles obtained in the third step with a gastric coating material by spraying on a one-step granulator, drying, and sieving with a 20-mesh sieve to obtain the calcium polycarbophil particles.
Example 4: comparison test of the polycarbophil granules obtained by the patent method with other similar products (piglets)
120 piglets, 28-60 days old and with obvious diarrhea symptoms, were selected and randomly divided into 4 test groups, each of which had 30 piglets. The 4 test groups are respectively a drug control group (the addition amount of nosiheptide is 20mg/kg), a low dose group (1 g/head per day), a medium dose group (5 g/head per day) and a high dose group (10 g/head per day), the test period is 3 days, and the diarrhea cure condition of piglets of each group is inspected; the administration mode is that the calcium polycarbophil granules are mixed with piglet feed and then fed, the nosiheptide premix is mixed with the piglet feed and then fed, the feed is freely fed during the experiment period, meanwhile, sufficient drinking water is provided, and other daily management measures are carried out according to the conventional management of a farm. The therapeutic effect is shown in table 1.
TABLE 1 comparison of the effectiveness of calcium polycarbophil in treating diarrhea in piglets (28-60 days old)
| Group of | Total number (only) | Cure (only) | Effective (only) | Invalid (only) | Effective (only) | High efficiency |
| Control group | 30 | 15 | 4 | 1 | 19 | 95％ |
| Low dose group | 30 | 14 | 3 | 3 | 17 | 85％ |
| Middle dose group | 30 | 19 | 1 | 0 | 20 | 100％ |
| High dose group | 30 | 20 | 0 | 0 | 20 | 100％ |
As can be seen from table 1, the polycarbophil calcium granules can treat diarrhea of piglets, and compared with a control group, the treatment effect of a low-dose group is smaller than that of a drug control group; the treatment effect of the medium and high dose groups is better than that of the drug control group.
Example 5: comparison test of the calcium polycarbophil granules obtained by the patent method with other similar products (middle pig)
120 middle pigs with the age of 90-120 days, the weight of 30-60kg and obvious diarrhea symptoms are selected and randomly divided into 4 test groups, and each group has 30 pigs. The 4 test groups are respectively a drug control group (the addition amount of nosiheptide is 40mg/kg), a low dose group (1 g/head per day), a medium dose group (2 g/head per day) and a high dose group (3 g/head per day), the test period is 3 days, and the diarrhea cure condition of each group is inspected; the administration mode is to feed the calcium polycarbophil and the middle pig feed after mixing, feed the nosiheptide premix and the middle pig feed after mixing, freely feed during the experiment, provide sufficient drinking water at the same time, and perform other daily management measures according to the conventional management of a farm. The therapeutic effect is shown in table 2.
TABLE 2 comparison of the Effect of calcium polycarbophil on treating diarrhea in pigs (90-120 days old)
| Group of | Total number (only) | Cure (only) | Effective (only) | Invalid (only) | Effective (only) | High efficiency |
| Control group | 30 | 15 | 3 | 2 | 18 | 90％ |
| Low dose group | 30 | 13 | 3 | 4 | 16 | 80％ |
| Middle dose group | 30 | 18 | 1 | 1 | 19 | 95％ |
| High dose group | 30 | 20 | 0 | 0 | 20 | 100％ |
As can be seen from Table 2, the calcium polycarbophil granules can treat diarrhea of middle pigs, and compared with a control group, the treatment effect of a low-dose group is smaller than that of a drug control group; the treatment effect of the medium and high dose groups is better than that of the drug control group.
Example 6 comparison of calcium polycarbophil granules obtained according to the method of the present patent with other similar products (broiler chickens)
120 broilers with different growth stages and obvious diarrhea symptoms are selected and randomly divided into 4 test groups, and each group has 30 broilers. The 4 test groups are respectively a drug control group (nosiheptide adding amount is 20mg/kg), a low dose group (1 g/piece per day), a medium dose group (2 g/piece per day) and a high dose group (3 g/piece per day), the test period is 3 days, and the diarrhea cure condition of each group is inspected; the administration mode is to feed after mixing calcium polycarbophil and broiler feed, and the nosiheptide premix is fed after mixing with the broiler feed, and during the experiment, the feed is freely taken, and sufficient drinking water is provided at the same time, and other daily management measures are carried out according to the conventional management of a farm. The therapeutic effect is shown in table 3.
TABLE 3 comparison of the Effect of calcium polycarbophil on treating diarrhea in broiler chickens
| Group of | Total number (only) | Cure (only) | Effective (only) | Invalid (only) | Effective (only) | High efficiency |
| Control group | 30 | 16 | 2 | 2 | 18 | 95％ |
| Low dose group | 30 | 13 | 3 | 4 | 16 | 80％ |
| Middle dose group | 30 | 18 | 1 | 1 | 19 | 95％ |
| High dose group | 30 | 20 | 0 | 0 | 20 | 100％ |
As can be seen from Table 3, the polycarbophil calcium granules can treat diarrhea of broiler chickens, and compared with a control group, the treatment effect of a low-dose group is smaller than that of a drug control group; the treatment effect of the medium and high dose groups is equivalent to or better than that of the drug control group.
EXAMPLE 7 comparison of calcium polycarbophil granules obtained by the method of this patent with other similar products (meat ducks)
120 meat ducks with different growth stages and obvious diarrhea symptoms are selected and randomly divided into 4 test groups, and each group has 30 heads. The 4 test groups are respectively a drug control group (nosiheptide adding amount is 20mg/kg), a low dose group (1 g/piece per day), a medium dose group (2 g/piece per day) and a high dose group (3 g/piece per day), the test period is 3 days, and the diarrhea cure condition of each group is inspected; the administration mode is that the calcium polycarbophil granules are mixed with meat duck feed and then fed, the nosiheptide premix is mixed with the meat duck feed and then fed, the meat duck feed is freely fed during the experiment period, sufficient drinking water is provided at the same time, and other daily management measures are carried out according to the conventional management of a farm. The therapeutic effect is shown in table 4.
TABLE 4 comparison of the effect of calcium polycarbophil on treating diarrhea of meat ducks
| Group of | Total number (only) | Cure (only) | Effective (only) | Invalid (only) | Effective (only) | High efficiency |
| Control group | 30 | 17 | 1 | 2 | 18 | 95％ |
| Low dose group | 30 | 14 | 2 | 4 | 16 | 80％ |
| Middle dose group | 30 | 17 | 2 | 1 | 19 | 95％ |
| High dose group | 30 | 20 | 0 | 0 | 20 | 100％ |
As can be seen from Table 4, the calcium polycarbophil granules can treat diarrhea of meat ducks, and compared with a control group, the treatment effect of a low-dose group is smaller than that of a drug control group; the treatment effect of the medium and high dose groups is equivalent to or better than that of the drug control group.
And (4) conclusion: the calcium polycarbophil granules can obviously treat livestock diarrhea.
The above-mentioned embodiments are intended to illustrate the present invention, but not to limit the present invention, and any modifications, equivalents, improvements, etc. made within the spirit of the present invention and the scope of the claims are included in the present invention.
Claims (10)
1. A dual release calcium polycarbophil granule, which is characterized in that: the granule consists of a slow-release core layer, a quick-release outer layer and a gastric coating material layer, wherein the mass percentages of the layers are as follows: 50-70% of slow-release core layer, 10-30% of quick-release outer layer and 10-20% of gastric-soluble coating material layer, wherein
The slow release core layer is processed from the following components in percentage by mass:
calcium polycarbophil 2-10%
Gluten powder 20-50%
15-30% of hydroxypropyl cellulose
10 to 40 percent of plasticizer
1 to 3 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
40-80% of calcium polycarbophil
3 to 8 percent of propylene glycol
20 to 50 percent of binder
5 to 20 percent of disintegrating agent
The balance being pure water.
2. The dual release calcium polycarbophil granule of claim 1, wherein: the granule consists of a slow release core layer, a quick release outer layer and a gastric coating material layer, wherein the mass percentages of the layers are as follows: 55% of a slow release core layer, 30% of a quick release outer layer and 15% of a gastric coating material layer, wherein
The slow release core layer is processed from the following components in percentage by mass:
10 percent of calcium polycarbophil
Gluten powder 20%
Hydroxypropyl cellulose 20%
15 percent of plasticizer
2 percent of surfactant
The balance being pure water;
the quick-release outer layer is processed by the following components in percentage by mass:
50 percent of polycarbophil calcium
Propylene glycol 5%
20 percent of binder
8 percent of disintegrating agent
The balance being pure water.
3. The dual release calcium polycarbophil granule of claim 1, wherein: the binder is at least one of corn starch and dextrin.
4. A dual release calcium polycarbophil granule as claimed in claim 1, wherein: the disintegrant is at least one of croscarmellose sodium, crospovidone, low-substituted hydroxypropyl cellulose, and sodium carboxymethyl starch.
5. A dual release calcium polycarbophil granule as claimed in claim 1, wherein: the plasticizer is at least one of ethyl cellulose, acrylic resin and polymethyl methacrylate.
6. A dual release calcium polycarbophil granule as claimed in claim 1, wherein: the surfactant is span and/or poloxamer.
7. A method for preparing the dual release calcium polycarbophil granule according to claim 1, wherein: the preparation method of the double-release type calcium polycarbophil granules comprises the following steps:
first, a sustained-release core layer is prepared
Uniformly mixing the calcium polycarbophil, the wheat gluten, the hydroxypropyl cellulose, the plasticizer and the surfactant according to the prescription amount, granulating in a one-step granulator in one step, drying on a fluidized bed to obtain dry granules, and sieving by a 20-60-mesh sieve;
second, preparing a quick-release outer layer
Uniformly mixing the calcium polycarbophil, the propylene glycol, the disintegrant material and the binder according to the prescription amount, adding pure water, and uniformly mixing to obtain a slurry material;
thirdly, granulating
Spraying the slurry material obtained in the second step on the dry particles obtained in the first step in a granulator, and sieving;
fourthly, coating
And (3) coating the dry particles obtained in the third step with a gastric coating material by spraying on a one-step granulator, drying, and sieving with a 20-mesh sieve to obtain the calcium polycarbophil particles.
8. The use of the double-release polycarbophil calcium granules as defined in any one of claims 1-6 in the preparation of a medicament for preventing and treating livestock and poultry diarrhea diseases.
9. A premix or batch comprising the dual release calcium polycarbophil granules of any one of claims 1-6.
10. A granule comprising the dual release calcium polycarbophil granule of any one of claims 1-6.
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