CN109009308A - Substance and preparation method thereof is shunk for aneurysmal degradable embolism - Google Patents
Substance and preparation method thereof is shunk for aneurysmal degradable embolism Download PDFInfo
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- CN109009308A CN109009308A CN201811029106.9A CN201811029106A CN109009308A CN 109009308 A CN109009308 A CN 109009308A CN 201811029106 A CN201811029106 A CN 201811029106A CN 109009308 A CN109009308 A CN 109009308A
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- embolism
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- aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses one kind to shrink substance for aneurysmal degradable embolism, it is characterized in that it is that the embolism made of degradable material shrinks substance that degradable embolism, which shrinks substance, degradable material is by poly-p-dioxanone, either polyglycolic acid, either poly (glycolide-lactide), either polylactic acid is silk material made of material, it is the spherical surface body that the unit spiral winding formed by single silk material continuous winding is constituted that the embolism, which shrinks substance, the axis of the unit spiral winding is extended outwardly with the spherical surface body centre of sphere, the present invention is due to using the above structure, with structure novel, therapeutic effect is significant, without complication, the advantages that thoroughly solving postoperative aneurysm occupation time process.
Description
Technical field
The present invention relates to the field of medical instrument technology, specifically a kind of to be used for aneurysmal degradable embolism constrictor
Matter and preparation method thereof.
Background technique
Currently, intracranial aneurysm prevalence is about 6%, clinically for aneurysm patient, primary treatments at present
First is that endovascular intervention treat, generally use spring ring to aneurysm carry out physics filling treatment.The material of spring ring
Generally platinum alloy.The purpose of embolotherapy is to make to be clogged by spring ring machinery in a short time in aneurysm body, and in chronic phase
Promote thrombosis in tumor, promotes endothelialization at tumor neck, aneurysm is made to entirely shut and achieve the effect that non-permanent treatment.But
Spring ring can be permanently present in knurl, and aneurysm volume will not change over time small, and big or giant aneurysm is then formed
Permanent occupation time process.For these big or huge complicated intracranial aneurysms, clinical essential therapeutic arsenals include opening cranium artery
Tumor is directly pressed from both sides and is closed, and aneurysm is isolated plus put up a bridge, and intervention Coil embolization treatment etc., but treatment difficulty is high, operation risk is big, art
Infectious-related complication incidence is higher.For the treatment prognosis for improving this kind of patient, the blood flow guiding device for belonging to interventional therapy scope is answered
It transports and gives birth to, and be worldwide used widely.It has operation relatively easy, and wound is small, and cure rate is high, and recurrence rate is low
Even without recurrence, complication rate is compared with other therapeutic modalities without advantages such as increases.The metal covering of blood flow guiding device
Rate is significantly improved compared with ordinary stent.It is entirely different with conventional springs circle aneurysm embolization to treat principle.It mainly passes through increasing
Add the metal coverage rate of tumor neck position, so that the blood flow entered in aneurysm cavity be made to significantly reduce, or even disappear, to induce dynamic
The intracavitary thrombosis of arteries and veins tumor, and promote endothelialization at tumor neck.But it is found in practical clinical, big or giant aneurysm uses
After this method treatment, if aneurysm is easy to appear rupture haemorrhage in a short time after the treatment without any embolism materials in tumor,
And the death rate after occurring is very high.The thrombus for being considered newly being formed of tracing it to its cause is highly unstable, can generate thrombus self-dissolving,
To discharge lyase, makes the aneurysm rupture of some patientss and lead to postoperative hemorrhage.So to reduce or preventing such case
Occur, clinically big or giant aneurysm is suggested putting in aneurysm at present when being treated using blood flow guiding device
Set enough spring rings.The spring ring placed in aneurysm belongs to foreign matter, and the thrombus Partial Conversion formed in aneurysm at this time
To be denaturalized thrombus, and autolysis does not occur for this thrombus, to reduce the generation of autolytic enzyme, and reduces aneurysm rupture
Probability.It is thirdly the presence due to blood flow guiding device at tumor neck, the blood still entered in tumor flows out difficulty from tumor neck,
It is excessively formed so as to cause thrombus in aneurysm, so as to cause aneurysm rupture.And with spring ring carry out filling can be further
It reduces blood at tumor neck to enter in aneurysm, to reduce the slip gradient for the treatment of artery tumor.Due to taking blood flow guiding
Device places appropriate spring ring after placing in aneurysm, clinically considerably reduces the probability of postoperative hemorrhage really.But this
Kind method equally brings new problem: since there is still a need for the metal elastic spring coils of filling nonabsorable in aneurysm, so that artery
The volume of tumor is retained, and occupation time process persistently exists, even if aneurysm heals completely, completely interior membranization at tumor neck.Institute
Aneurysm cavity, which is temporarily filled, with the material that can be absorbed for a long time in use in this case reduces short-term bleeding probability, and middle length
Phase can be absorbed again and reduce occupation time process, become more satisfactory treatment method.
Through retrieving, CN104739478B discloses a kind of patent of invention of spring ring and preparation method thereof comprising first
Coil and the second coil, the first coil are wound on the second coil lateral surface, and one of coil is degradation material, another
Coil is nontransmissive material, and the percentage that the volume of degradation material accounts for spring ring volume is 75%-95%.The essence of this structure
Property deficiency is: can accelerate the fibrosis of thrombus in aneurysm after the implantation, although biomaterial is being degraded, since its structure is
The first coil is wound on the second coil lateral surface, and one of coil is not transmission metal material, still suffers from spring ring
It is permanently present in knurl, shape does not have substantial reduction, and therefore, the occupation time process of aneurysm inner body is not from basic
Upper solution.
Summary of the invention
Present invention aim to address above-mentioned the deficiencies in the prior art, provide that a kind of structure novel, therapeutic effect be significant, nothing
Complication, the aneurysmal degradable embolism that is used for for thoroughly solving postoperative aneurysm occupation time process shrink substance and its preparation side
Method.
The present invention solve above-mentioned technical problem the technical solution adopted is that:
One kind shrinking substance for aneurysmal degradable embolism, it is characterised in that it is by degradable that degradable embolism, which shrinks substance,
Material made of embolism shrink substance, degradable material be by poly-p-dioxanone or be polyglycolic acid or
Person is poly (glycolide-lactide) or is polylactic acid for silk material made of material, and the silk material diameter is 0.05-0.4mm, the embolism
Shrinking substance is the spherical surface body that the unit spiral winding formed by single silk material continuous winding is constituted, the unit spiral winding
Axis is extended outwardly with the spherical surface body centre of sphere, so that degradable embolism is shunk at substance fitting aneurysm tumor wall and knurl footpath, in turn
So that the present invention reduces or block during surgery the blood flow still entered in aneurysm, keep the present invention quick in the aneurysm
Cause to be denaturalized thrombosis, and further promotes endothelialization at aneurysm neck in chronic phase；In addition, the contraction substance that embolism uses
Within 2-6 months time gradually degradation releases carbon dioxide and water, not no embolism materials in aneurysm after some months
In the presence of the occupy-place effect for significantly solving big or giant aneurysm so that disappearing is gradually reduced in aneurysm gradually atrophy, volume
It answers, improves the postoperative recovery effects of intracranial aneurysm patients.
The angle of adjacent cells spiral winding axis in spherical surface body of the present invention is different, the unit spiral winding
Different angle is less than 180 degree being more than or equal to 10 degree, fits closely so as to be implanted to each face in aneurysm with aneurysm wall,
Stablize thrombus, prevents aneurysm rupture bleeding.
Of the present invention different according to spherical surface body quantity, adjacent cells spiral winding angle is different, unit spiral coil it is straight
Diameter is different, and the different-diameter of the unit spiral winding further stops thrombus impact aneurysm between 1-30mm, to reach, and prevents
Only aneurysm rupture haemorrhage.
The diameter of the silk material of unit spiral winding of the present invention is preferably 0.1-0.35mm, further to promote aneurysm
Endothelialization improves the postoperative therapeutic effect of intracranial aneurysm patients.
A kind of preparation method for shrinking substance for aneurysmal degradable embolism, characteristic method and step are as follows:
One, the silk material of degradable material and the shaper of spherical surface body are made；
Two, degradable embolism is made by shaper and shrinks substance.
First method step of the present invention specifically:
Using poly-p-dioxanone or be polyglycolic acid or be poly (glycolide-lactide) or be polylactic acid be material
It is spare after the silk material of 0.05-0.4mm that diameter, which is made,；
Prepare polyhedron shaper, cylindrical body is stretched out in each face, then the cylindrical body in each face is numbered, by silk material along volume
Number successively it is wound up as multiple and different diameters, the unit spiral winding of different angle constitutes the spherical surface body of embolism；
It is 50-200 degree that high-temperature shaping temperature is carried out after the completion of coiling, removed from shaper after sizing cylindrical body to get to
Molding degradable embolism shrinks substance.
The present invention due to using the above structure and preparation method, have structure novel, therapeutic effect it is significant, without complication,
The advantages that thoroughly solving postoperative aneurysm occupation time process.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention.
Fig. 2 is the structural schematic diagram of the shaper of 6 face spherical surface bodies of the invention.
Fig. 3 is the structural schematic diagram that embolism shrinks that substance is wrapped in the shaper of Fig. 2.
Fig. 4 is the structural schematic diagram of the shaper of 12 face spherical surface bodies of the invention.
Fig. 5 is the structural schematic diagram that embolism shrinks that substance is wrapped in the shaper of Fig. 4.
Appended drawing reference: embolism shrinks substance 13.
Specific embodiment
The following further describes the present invention with reference to the drawings:
As shown in Fig. 1, a kind of to shrink substance for aneurysmal degradable embolism, it is characterised in that degradable embolism constrictor
Matter is that the embolism made of degradable material shrinks substance 13, degradable material be by poly-p-dioxanone or
It is polyglycolic acid or is poly (glycolide-lactide) or be polylactic acid is silk material made of material, the silk material diameter is
0.05-0.4mm, it is the spherical surface that the unit spiral winding formed by single silk material continuous winding is constituted that the embolism, which shrinks substance,
Body, the axis of the unit spiral winding are extended outwardly with the spherical surface body centre of sphere, are moved so that degradable embolism shrinks substance fitting
At vein tumour paries and knurl footpath, so that the present invention reduces or block during surgery the blood flow still entered in aneurysm, make this
Invention quickly results in denaturation thrombosis described in aneurysm, and further promotes endothelium at aneurysm neck in chronic phase
Change；In addition, the contraction substance that embolism uses gradually degraded within 2-6 months time and releases carbon dioxide and water, some months
The not presence of embolism materials in aneurysm later, aneurysm gradually atrophy, volume-diminished or disappearance have well solved big
Or the occupation time process of giant aneurysm, improve the postoperative recovery effects of intracranial aneurysm patients
The angle of adjacent cells spiral winding axis in spherical surface body of the present invention is different, the difference of the unit spiral winding
Angle is less than 180 degree being more than or equal to 10 degree, fits closely so as to be implanted to each face in aneurysm with aneurysm wall, stablizes
Thrombus prevents aneurysm rupture bleeding.
Of the present invention different according to spherical surface body quantity, adjacent cells spiral winding angle is different, and specification is different, unit spiral shell
The diameter of volution is different, and the different-diameter of the unit spiral winding further stablizes thrombus between 1-30mm, to reach, and prevents
Aneurysm rupture bleeding.
The diameter of the silk material of unit spiral winding of the present invention is preferably 0.1-0.35mm, further to promote aneurysm
Endothelialization improves the postoperative therapeutic effect of intracranial aneurysm patients.
A kind of preparation method for shrinking substance for aneurysmal degradable embolism, characteristic method and step are as follows:
One, the silk material of degradable material and the shaper of spherical surface body are made；
Two, degradable embolism is made by shaper and shrinks substance.
First method step of the present invention specifically:
Using poly-p-dioxanone or be polyglycolic acid or be poly (glycolide-lactide) or be polylactic acid be material
It is spare after the silk material of 0.05-0.4mm that diameter, which is made,；Either using poly-p-dioxanone or be polyglycolic acid,
Either poly (glycolide-lactide) or to be that polylactic acid is that material is made spare after the silk material that diameter is 0.1-0.35mm；
Prepare the shaper of multiple spherical surface bodies, multiple spherical surface body shapers of the present invention are preferably distinguished with 6 faces and 12 faces
It is illustrated:
Prepare 6 face shapers, cylindrical body is stretched out in each face, then the cylindrical body in each face is numbered, by silk material along number
It is wound in circle for 1 cylindrical body, is then successively wound up as 6 unit spiral windings by number for the cylindrical body of 2-3-4-5-6,
6 different-diameters, different angle unit spiral winding constitute the spherical surface body of embolism；
Prepare 12 face shapers, cylindrical body is stretched out in each face, then the cylindrical body in each face is numbered, by silk material along number
It is wound in circle for 1 cylindrical body, is then successively wound up as by number for the cylindrical body of 2-3-4-5-6-7-8-9-10-11-12
12 unit spiral windings, 12 different-diameters, different angle unit spiral winding constitute the spherical surface body of embolism；
It is 50-200 degree that high-temperature shaping temperature is carried out after the completion of coiling, removed from shaper after sizing cylindrical body to get to
Molding degradable embolism shrinks substance, as shown in Fig. 1.
In clinical use, doctor is first discharged blood flow guiding device by transportation system the present invention along microtubular
In parent artery where cerebral aneurysm, and stablize covered tumor neck, is then again put into the present invention in aneurysm cavity along in advance
Microtubular be implanted in aneurysm, freed by machinery, electric heating is freed, electric ways of relief stays degradable embolism contraction substance
In aneurysm, degradable embolism shrink substance due to use poly-p-dioxanone completely or be polyglycolic acid or
Person is made of poly (glycolide-lactide) or is polylactic acid material, and it is spherical surface body that degradable embolism, which shrinks substance, adjacent in spherical surface body
The angle of unit spiral winding axis is different with the diameter of adjacent cells spiral winding, further stablizes thrombus in tumor, anti-stop
Arteries and veins tumor rupture haemorrhage, meanwhile, degradable embolism, which shrinks substance, can further promote to form thrombus, degradable embolism in aneurysm
Filling aneurysm can be stablized in 2 months by shrinking substance, and gradually promote aneurysm neck endothelialization, degradable after 2 months
Embolism shrinks substance and is gradually degraded into water and carbon dioxide, and degradation material is degraded completion substantially after 6 months, does not have in aneurysm
Any foreign matter residual, without the presence of any occupation time process, aneurysm gradually atrophy, and then in blood flow guiding device at tumor neck
Endothelialization under skeleton cures aneurysmal purpose to reach, and the aneurysm for protruding arterial wall thoroughly disappears.
The present invention due to using the above structure and preparation method, have structure novel, therapeutic effect it is significant, without complication,
The advantages that thoroughly solving postoperative aneurysm occupation time process.
Claims (6)
1. one kind shrinks substance for aneurysmal degradable embolism, it is characterised in that it is by that can drop that degradable embolism, which shrinks substance,
Embolism made of the material of solution shrink substance, degradable material be by poly-p-dioxanone or be polyglycolic acid,
Either poly (glycolide-lactide) or be polylactic acid be material made of silk material, the silk material diameter be 0.05-0.4mm, the bolt
It is the spherical surface body that the unit spiral winding formed by single silk material continuous winding is constituted that plug, which shrinks substance, and spherical surface body is the face 6-12,
The axis of the unit spiral winding is extended outwardly with the spherical surface body centre of sphere.
2. according to claim 1 a kind of for aneurysmal degradable embolism contraction substance, it is characterised in that the ball
The angle of adjacent cells spiral winding axis on the body of face is different, and the different angle of the unit spiral winding is more than or equal to 10 degree
And it is less than 180 degree.
3. according to claim 2 a kind of for aneurysmal degradable embolism contraction substance, it is characterised in that the ball
The diameter of adjacent cells spiral winding on the body of face is different, and the different-diameter of the unit spiral winding is between 1-30mm.
4. according to claim 2 a kind of for aneurysmal degradable embolism contraction substance, it is characterised in that the list
The diameter of the silk material of first spiral winding is 0.1-0.35mm.
5. a kind of preparation method for shrinking substance for aneurysmal degradable embolism according to claim 3 or 4, special
Sign is method and step are as follows:
Make the silk material of degradable material and the shaper of spherical surface body；
Degradable embolism, which is made, by shaper shrinks substance.
6. a kind of preparation method for shrinking substance for aneurysmal degradable embolism according to claim 5, feature
It is first method step of the present invention specifically:
Using poly-p-dioxanone or be polyglycolic acid or be poly (glycolide-lactide) or be polylactic acid be material
It is spare after the silk material of 0.05-0.4mm that diameter, which is made,；
Prepare polyhedron shaper, cylindrical body is stretched out in each face, then the cylindrical body in each face is numbered, by silk material along volume
Number successively it is wound up as multiple and different diameters, the unit spiral winding of different angle constitutes the spherical surface body of embolism；
It is 50-200 degree that high-temperature shaping temperature is carried out after the completion of coiling, removed from shaper after sizing cylindrical body to get to
Molding degradable embolism shrinks substance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810651971 | 2018-06-22 | ||
| CN2018106519710 | 2018-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109009308A true CN109009308A (en) | 2018-12-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811029106.9A Pending CN109009308A (en) | 2018-06-22 | 2018-09-05 | Substance and preparation method thereof is shunk for aneurysmal degradable embolism |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288315A (en) * | 2021-06-21 | 2021-08-24 | 上海鸿脉医疗科技有限公司 | Medical implant and manufacturing method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322576B1 (en) * | 1997-08-29 | 2001-11-27 | Target Therapeutics, Inc. | Stable coil designs |
| WO2001093937A2 (en) * | 2000-06-08 | 2001-12-13 | Micrus Corporation | Three dimensional, low friction coil, and method of manufacture |
| CN104739479A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
| CN104739478A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
| US20150182227A1 (en) * | 2013-12-27 | 2015-07-02 | Blockade Medical, LLC | Coil system |
| CN107773283A (en) * | 2016-08-31 | 2018-03-09 | 微创神通医疗科技（上海）有限公司 | Implant, implant preparation method and implant system |
-
2018
- 2018-09-05 CN CN201811029106.9A patent/CN109009308A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322576B1 (en) * | 1997-08-29 | 2001-11-27 | Target Therapeutics, Inc. | Stable coil designs |
| WO2001093937A2 (en) * | 2000-06-08 | 2001-12-13 | Micrus Corporation | Three dimensional, low friction coil, and method of manufacture |
| US20150182227A1 (en) * | 2013-12-27 | 2015-07-02 | Blockade Medical, LLC | Coil system |
| CN104739479A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
| CN104739478A (en) * | 2013-12-31 | 2015-07-01 | 微创神通医疗科技（上海）有限公司 | Spring coil and production method thereof |
| CN107773283A (en) * | 2016-08-31 | 2018-03-09 | 微创神通医疗科技（上海）有限公司 | Implant, implant preparation method and implant system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288315A (en) * | 2021-06-21 | 2021-08-24 | 上海鸿脉医疗科技有限公司 | Medical implant and manufacturing method thereof |
| WO2022267904A1 (en) * | 2021-06-21 | 2022-12-29 | 上海鸿脉医疗科技有限公司 | Medical implant and manufacturing method therefor |
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