CN109009103A - The detection of the biofeedback type disturbance of consciousness and wake-up system - Google Patents
The detection of the biofeedback type disturbance of consciousness and wake-up system Download PDFInfo
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Abstract
The invention discloses a kind of detection of biofeedback type disturbance of consciousness and wake up system, including personalized audiovisual stimulating apparatus, disturbance of consciousness evaluation module and through cranium galvanic current stimulation device, personalized audiovisual stimulating apparatus provides the stimulation of diagnosis and the wake-up scheme of consciousness simultaneously；Disturbance of consciousness evaluation module includes brain wave acquisition device, integrated simulation front end, main control unit, bluetooth unit, Power Management Unit.Eeg signal acquisition device is connected by interface with integrated simulation front end, and integrated simulation front end is connected with main control unit；Main control unit is controlled according to brain electrical characteristic values through cranium galvanic current stimulation device, and eeg data is transferred to personalized audiovisual stimulating apparatus to control different personalized audiovisual stimulation protocols by bluetooth unit, and Power Management Unit is associated components power supply.Detection, diagnosis and the rehabilitation integration of the disturbance of consciousness dynamic regulation can be waken up scheme according to testing result by the present invention, and validity is high, and as a result accurately, to early stage, the recovery of consciousness is of great significance.
Description
Technical field
The present invention relates to biological brain telecommunications fields, and in particular to a kind of detection of the biofeedback type disturbance of consciousness and calls out
The system of waking up.
Background technique
The disturbance of consciousness is common clinical symptoms after serious cerebral injury, is divided into brain death, stupor, vegetative state, micro- consciousness
State, apallic syndrome (actually regain consciousness, but be listed in this series of studies).China increases disturbance of consciousness patient about 100,000 newly every year,
Need to spend up to ten thousand yuan of 10-50 for the treatment of and nursing expense every year, so huge patient populations and enormous expenditure to family and
Society brings great burden.
It clinically relies primarily on various marking scales at present and doctor's experience comments the degree of the disturbance of consciousness and prognosis
Valence not only has very strong subjectivity and hysteresis quality, and it is even more impossible to capture the recovery of early stage consciousness, misdiagnosis rate is up to 43%.Cause
This, it is still medicine great difficulty urgently to be resolved that objectively evaluation and test disturbance of consciousness patient, which has unconscious, and determines efficient rehabilitation scheme
Topic.
Research has proven to can be by electroencephalogram (EEG), Positron Emission Computed Tomography technology (PET) and function magnetic
The means such as resonance image-forming technology (fMRI) detect disturbance of consciousness person's brain activity, but existing normal form does not have personalization, it is difficult to relate to
And the unique conscious experience content of disturbance of consciousness person, effect is limited in terms of consciousness assessment and wake-up.
Name, emotion picture etc. are called out in existing research confirmation can cause disturbance of consciousness person part brain area to be activated by specificity, and more
Channel stimulation is stimulated than single channel can cause the more behavior responses of disturbance of consciousness person, but the stimulation used of finding report is standard
Normal form can not touch the deep layer conscious content of disturbance of consciousness person's differentiation.In recent years, bio-feedback therapeutic apparatus was as a kind of new
Equipment is used in numerous disease areas, achieves positive therapeutic effect, plays positive reference function to development of the invention.
Summary of the invention
The purpose of the present invention is to solve drawbacks described above in the prior art, provide a kind of biofeedback type disturbance of consciousness
Detection and wake-up system realize personalized audiovisual stimulation and the automatic adjusument through cranium galvanic current stimulation, form effective health
Compound case is conducive to improve detection efficiency, reduces cost.
The purpose of the present invention can be reached by adopting the following technical scheme that:
A kind of detection of the biofeedback type disturbance of consciousness and system is waken up, the system includes personalized audiovisual stimulation dress
Set, disturbance of consciousness evaluation module and through cranium galvanic current stimulation device, the disturbance of consciousness evaluation module include brain wave acquisition device,
Integrated simulation front end, main control unit, bluetooth unit, Power Management Unit, wherein the brain wave acquisition device by electrode and
USB interface is connected with integrated simulation front end, and the integrated simulation front end is connected by SPI with main control unit, the master control
Unit is connected by UART with the bluetooth unit, and the bluetooth unit passes through with the personalized audiovisual stimulating apparatus
Bluetooth wireless information interaction, and by bluetooth unit by the eeg data of main control unit be transferred to personalized audiovisual stimulating apparatus come
Different personalized audiovisual stimulation protocols is controlled,
Described connect through cranium galvanic current stimulation device with the main control unit, according to the brain electrical characteristic values of main control unit
Adjust personalized audiovisual stimulation material and stimulus type, output direct current electric strength through cranium galvanic current stimulation, wherein the warp
The stimulus type of cranium galvanic current stimulation includes stimulus of direct current, impulse stimulation, sinusoidal stimulation and pseudo- stimulation.
Further, the personalized audition stimulation protocol is designed based on psychological principle, by collecting and screening meaning
Know the relevant recall info of obstacle person, selects optimal light, sound, the combination of shadow and presentation time, wherein recall info
, memory most deep people, object, thing favorite including disturbance of consciousness person.
Further, the disturbance of consciousness evaluation module further includes Power Management Unit, the Power Management Unit
It powers for integrated simulation front end, main control unit, through cranium galvanic current stimulation device.
Further, the brain wave acquisition device includes cap, monopole eeg sensor, reference electrode, wherein described
The inside of cap, and the forehead skin contact with wearer is arranged in monopole eeg sensor；The reference electrode and cap
Lower edge be connected, and be clipped at the ear-lobe of wearer；The reference electrode is brain electricity patch electrode；
The monopole eeg sensor and reference electrode are connect with integrated simulation front end respectively.
Further, the ADS1299 chip of TI company, including sequentially connected multichannel are selected in the integrated simulation front end
Multiplexer, detection components, filter, low noise gain amplifier, high-resolution analog-digital converter, biasing driving amplifier, vibration
Device and serial peripheral equipment interface SPI are swung,
The integrated simulation front end amplifies collected EEG signals, filter and analog-to-digital conversion after by serial
Peripheral Interface SPI is transferred to main control unit.
Further, described through cranium galvanic current stimulation device includes D/A converter module, constant current source module and surface
Electrode, this exports stimulus of direct current, impulse stimulation, sinusoidal thorn according to the brain electrical characteristic values of main control unit through cranium galvanic current stimulation device
Swash and pseudo- stimulation, the stimulus signal of output after D/A converter module carries out digital-to-analogue conversion through constant current source module, by be suitable for
Electric current is exported to surface electrode, and acts on disturbance of consciousness person's target region.
Further, described through cranium galvanic current stimulation device further includes overcurrent protection for limiting circuit transient current
Circuit, the current foldback circuit include NPN type triode T1, sampling resistor R1, pull-up resistor R2, FPGA and capacitor C1,
Wherein, the pole N of NPN type triode T1 is connected with pull-up resistor R2 and FPGA respectively, another pole N of NPN type triode T1
Ground connection, the pole P of NPN type triode T1 is grounded after being connected respectively with sampling resistor R1 and capacitor C1；Protect signal for overcurrent guarantor
The input signal of protection circuit, one end of input sample resistance R1 and capacitor C1；
When protecting signal code excessive, capacitor C1 slowly charges, and sampling resistor R1 generates high partial pressures, NPN type triode
T1 is switched on, and is exported high level through pull-up resistor R2, FPGA, is controlled the output of stimulus waveform, have the function that current limliting with this.
Further, the main control unit carries out EEG Processing, eliminates low frequency using wavelet package transforms first and makes an uproar
Acoustic jamming is then based on the blind source separation algorithm of maximum signal to noise ratio, and the artefact for EEG signals is filtered；Secondly with non-
Linear dynamics analysis method calculates real-time EEG signals multiple including dynamic Lempel-Ziv complexity, C0
EEG signals characteristic value including miscellaneous degree and entropy finally utilizes branch after the clustered parser processing of above-mentioned brain electrical characteristic values
It holds vector machine and carries out Classification and Identification, correspondence obtains different control instructions.
Further, the bluetooth unit uses TI instrument BLE-CC2640R2F chip.
The present invention has the following advantages and effects with respect to the prior art:
(1) disturbance of consciousness integrated estimation system combine Electrophysiology detection technique (EEG/ERP), functional MRI at
As technology (fMRI) and Positron Emission Computed Tomography technology (PET), and clinical behavior scale is combined, foundation is directed to
The multi-modal integrated database of disturbance of consciousness person, for disturbance of consciousness person consciousness assessment provide more comprehensively, objective Informational support.
(2) personalized audiovisual stimulating apparatus considers that previous standardized stimulation protocol is difficult to touch disturbance of consciousness person's difference
The conscious experience content of change, the present invention propose to formulate the personalized audiovisual stimulating apparatus designed based on psychological principle.Realizing
Assessment aspect, the program can be used as stimulation means, complete the disturbance of consciousness person in the state of closer to oneself true consciousness each
Item physiology detection, reduces misdiagnosis rate；In terms of consciousness wakes up with rehabilitation, personalized audiovisual stimulating apparatus has abundant, more senses
The features such as feeling channel, close real scene, is more conducive to cause the stronger behavior reaction of disturbance of consciousness patient, is expected to become a kind of conjunction
Manage effective Novel rehabilitation scheme.
(3) the four kinds of brain electrical features calculated with nonlinear dynamic analysis method integrated in main control unit of the present invention are calculated
Method value can reflect the nonlinear characteristic parameters difference of normal brain electric signal and disturbance of consciousness patient's EEG signals substantially, due to
EEG signals are directly measured by instrument, the signal processing in later period be calculated by all kinds of accurate algorithms of nonlinear analysis and
Analysis show that this method is compared with experience, scale, more objectifies and quantification, especially with clinically used electroencephalogram point
Phase separation ratio has certain advantage, is capable of the degree of consciousness of more accurate intuitive reflection brain, for controlling for the subsequent disturbance of consciousness
Treatment provides more accurately and reliably index.
Detailed description of the invention
Fig. 1 is the structural block diagram that system is detected and waken up based on the biofeedback type disturbance of consciousness of the embodiment of the present invention；
Fig. 2 be the embodiment of the present invention based on the biofeedback type disturbance of consciousness detect and wake up system midbrain electricity collector and
The structure function figure of integrated simulation front end；
Fig. 3 is the embodiment of the present invention for audiovisual stimulating apparatus moderate stimulation scheme system personalized in detection and its rehabilitation and arousal
Fixed figure；
Fig. 4 is the embodiment of the present invention for rehabilitation and arousal through cranium stimulation protocol figure；
Fig. 5 is the embodiment of the present invention through the protection circuit diagram in cranium galvanic current stimulation device；
Fig. 6 is the structure and its schematic diagram of the function of bluetooth unit used in the embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
Embodiment one
System is detected and waken up based on the biofeedback type disturbance of consciousness as shown in Figure 1, present embodiment discloses one kind, including
Personalized audiovisual stimulating apparatus, disturbance of consciousness evaluation module and through cranium galvanic current stimulation device, disturbance of consciousness evaluation module includes
Brain wave acquisition device, integrated simulation front end, main control unit, bluetooth unit, Power Management Unit.Brain wave acquisition device by electrode and
USB (Universal Serial Bus, universal serial bus) interface is connected with integrated simulation front end, and integrated simulation front end passes through
SPI (Serial Peripheral Interface, Serial Peripheral Interface (SPI)) is connected with main control unit, and main control unit passes through UART
(Universal Asynchronous Receiver/Transmitter, universal asynchronous receiving-transmitting transmitter) and bluetooth unit phase
Even, bluetooth unit is interacted with personalized audiovisual stimulating apparatus progress bluetooth wireless information, and Power Management Unit is before integrated simulation
End, main control unit are powered through cranium galvanic current stimulation device.
Wherein, brain wave acquisition device described in the present embodiment includes cap, monopole eeg sensor, reference electrode；
The inside of cap, and the forehead skin contact with wearer is arranged in the monopole eeg sensor；Described
Reference electrode is connected with the lower edge of cap, and is clipped at the ear-lobe of wearer；
The monopole eeg sensor and reference electrode are connect with integrated simulation front end respectively.
Specifically in the present embodiment, the ADS1299 chip of TI company, the integrated simulation are selected in the integrated simulation front end
Front end up to 8 low-noise programmable gain amplifiers (PGA) and 8 high-resolution synchronized sampling analog-digital converters (ADC), contain
There are internal reference and onboard oscillator, collected EEG signals are amplified, are filtered and analog-to-digital conversion.As Fig. 2 includes
Multiplexer, detection components, filter, low noise gain amplifier, high-resolution analog-digital converter, biasing drive amplification
Device, oscillator and serial peripheral equipment interface SPI.
The reference electrode is brain electricity patch electrode, and the EEG signals of acquisition pass through multiplexer, filter, amplification
After device and analog-to-digital conversion, master is transferred to by SPI (Serial Peripheral Interface, Serial Peripheral Interface (SPI)) interface
Control unit.
Specifically in the present embodiment, the main control unit selects TI (TEXAS INSTRUMENTS, Texas Instrument) company
MSP430FR5739 microcontroller, for the EEG signals of integrated simulation front-end processing to be received, handled and are stored, and
EEG signals are transferred to bluetooth unit and personalized audiovisual stimulating apparatus.
As shown in figure 3, personalized audition stimulation protocol is based on the heart in personalized audiovisual stimulating apparatus described in the present embodiment
Principle design of science.Specific formulating method: it from the angle at people one's own department or unit, in conjunction with psychology professional knowledge, collects and screening is anticipated
Know obstacle person it is relevant acquire a special sense, the recall info of intense emotion or major event, including disturbance of consciousness person most likes
, most deep people, object, the thing of memory etc.；When selecting optimal material method of producing (combination of light, sound, shadow) and presenting
Between.
As shown in figure 4, being pierced through cranium galvanic current stimulation device according to the exportable direct current of brain electrical characteristic values described in the present embodiment
Sharp, impulse stimulation, sinusoidal stimulation and pseudo- stimulation, the stimulus signal of output is after D/A converter module progress digital-to-analogue conversion through perseverance
Source module is flowed, suitable electric current is exported to surface electrode, and act on disturbance of consciousness person's target region.It is filled through cranium galvanic current stimulation
Stimulus type, the output direct current electric strength set do dynamic with the change of the control instruction of main control unit and adjust, and output, which fits well on, works as
Subconsciousness through cranium galvanic current stimulation.
As shown in figure 5, through cranium galvanic current stimulation device due to acting on human body described in the present embodiment, in order to guarantee
The state of work, the transient current of limiting circuit, it is necessary to which additional over-current protects circuit, to improve the stability and peace of whole system
Quan Xing.
The current foldback circuit includes NPN type triode T1, sampling resistor R1, pull-up resistor R2, FPGA and capacitor
C1, wherein the pole N of NPN type triode T1 is connected with pull-up resistor R2 and FPGA respectively, another N of NPN type triode T1
Pole ground connection, the pole P of NPN type triode T1 is grounded after being connected respectively with sampling resistor R1 and capacitor C1；Protection signal is overcurrent
Protect the input signal of circuit, one end of input sample resistance R1 and capacitor C1.
Due to low capacity type electric current and little, current sample is carried out using resistance R1, recycles capacitor C1 and NPN type three
Current spike is eliminated in the combination of pole pipe T1.Specific detection process, when protecting signal code excessive, capacitor C1 slowly charges, and adopts
Sample resistance R1 generates very high partial pressure, and NPN type triode T1 is switched on, through pull-up resistor R2, FPGA (Field
Programmable Gate Array, field programmable gate array) output high level, the output of stimulus waveform is controlled, is reached with this
To the effect of current limliting.
Specifically in the present embodiment, the bluetooth unit uses CC2640R2F chip, is applicable to
4.2 and Bluetooth, 5 low-power consumption application, as shown in fig. 6, including main control module, RF core module, common peripheral devices
Interface module and sensor control block.Main control module includes one 32Kernel is
Core (CM3) is united designed for running Bluetooth Low Energy protocol stack up to user application from link layer.It is set with other bluetooths
Standby to compare, Cortex M0 (CM0) kernel of RF core module is responsible for connecting radio hardware, and will come from Cortex M3
(CM3) complicated order of kernel is converted to the bit sent in the sky by radio.Sensor control block is difference and its
One unique portion of his BLE SOC chip, it is one 16 single-chip microcontrollers, the M3's and radio frequency box independently of main control unit
M0 work can independently realize the data acquisition to external sensor, to protect in the case where system other parts are all turned off
The low-power consumption of whole system operation is held, this framework can improve overall system performance and power consumption, and discharge a large amount of flash memories for application,
To provide greater flexibility.Peripheral Interface then contain GPIO (General Purpose Input Output, it is general
Input/output), timer, UART (Field Programmable Gate Array, field programmable gate array)/SPI
(Serial Peripheral Interface, Serial Peripheral Interface (SPI)), I2C, I2S interface and hardware AES (Advanced
Encryption Standard, Advanced Encryption Standard) encryption etc. functional interfaces.
Specifically in the present embodiment, the personalized audiovisual stimulating apparatus can receive the brain telecommunications of disturbance of consciousness person
Number, and clinical behavior scale is combined, the multi-modal integrated database for being directed to disturbance of consciousness patient is established, is disturbance of consciousness patient
Consciousness assessment provide more comprehensively, objective Informational support.
Embodiment two
Present embodiment discloses one kind to be detected and be waken up system, including personalized audiovisual based on the biofeedback type disturbance of consciousness
Stimulating apparatus, disturbance of consciousness evaluation module and through cranium galvanic current stimulation device, which provides examine simultaneously
Disconnected stimulation and consciousness wake-up scheme；The disturbance of consciousness evaluation module include brain wave acquisition device, integrated simulation front end, main control unit,
Bluetooth unit, Power Management Unit；The brain wave acquisition device includes cap, singly leads eeg sensor and reference electrode, singly leads brain electricity
Sensor is placed on the inside of cap, is contacted with forehead, and the lower edge connection of reference electrode and cap is clipped at ear lobe；Brain electricity
Collector is connected with integrated simulation front end, integrated simulation front end by SPI (Serial Peripheral Interface, serially
Peripheral Interface) it is connected with main control unit；Main control unit is controlled by EEG signals characteristic value and different is filled through cranium galvanic current stimulation
It sets and personalized audiovisual stimulating apparatus, and eeg data is transferred to by personalized audiovisual stimulating apparatus by bluetooth unit；Through cranium
Galvanic current stimulation device exports different stimulus types, output direct current electric strength according to different EEG signals characteristic values；Power supply pipe
Reason unit is integrated simulation front end, main control unit, through the power supply of cranium galvanic current stimulation device.
Specifically in the present embodiment, the personalized audiovisual stimulation protocol of the personalized audiovisual stimulating apparatus is based on psychology
Principle design is learned, including consciousness assessment, consciousness wake up and two aspects of rehabilitation.In terms of consciousness assessment, personalized audiovisual stimulation
Device can be used as diagnostic stimulation, detect disturbance of consciousness person closer to the every physiology of completion under oneself true state of consciousness,
Reduce misdiagnosis rate；In terms of consciousness wakes up with rehabilitation, personalized audiovisual stimulating apparatus is according to brain electrical characteristic values dynamic regulation individual character
Change the combination of audiovisual stimulation material and the time is presented, has the characteristics that abundant, multi-sensory, close to real scene, more
Be conducive to cause the stronger behavior reaction of disturbance of consciousness patient, a kind of rationally effective Novel rehabilitation therapeutic scheme can be become.
Specifically in the present embodiment, the brain wave acquisition device uses the brain wave acquisition scheme of 32 leads, according to cognition
The requirement of the difference, case of task records the synchronous discharge activity of each brain area using 32 multi-lead modes, to analyze simultaneously
Relationship and feature between each EEG signals；The system includes cap, monopole eeg sensor, reference electrode.
Specifically in the present embodiment, the inside of cap, and the volume with wearer is arranged in the monopole eeg sensor
Head skin contact；The reference electrode is connected with the lower edge of cap, and is clipped at the ear-lobe of wearer；
Specifically in the present embodiment, the monopole eeg sensor and reference electrode connect with integrated simulation front end respectively
It connects, integrated simulation front end, main control unit and the bluetooth unit are sequentially connected.
Specifically in the present embodiment, the integrated simulation front end uses the ADS1299 chip of TI company, the integrated simulation
Front end up to 8 low-noise programmable gain amplifiers (PGA) and 8 high-resolution synchronized sampling analog-digital converters (ADC), contain
There are internal reference and onboard oscillator, collected EEG signals are amplified, are filtered and analog-to-digital conversion.
Specifically in the present embodiment, the brain electrical analogue front end includes that multiplexer, filter, low noise gain are put
Big device, high-resolution analog-digital converter, biasing driving amplifier, oscillator and serial peripheral equipment interface SPI, the brain electricity patch
The EEG signals of electrode acquisition pass through after multiplexer, filter, amplifier and analog-to-digital conversion, by SPI (Serial
Peripheral Interface, Serial Peripheral Interface (SPI)) interface is transferred to main control unit.
Specifically in the present embodiment, the main control unit uses MSP430FR5969 processor, for integrated simulation
The EEG signals of front-end processing are received, handled and are stored, and EEG signals are transferred to bluetooth and display.
Specifically in the present embodiment, the main control unit carries out EEG Processing, is disappeared first using wavelet package transforms
Except low frequency noises, it is then based on the blind source separation algorithm of maximum signal to noise ratio, the artefact for EEG signals is filtered, and is
Next step EEG feature extraction and pattern-recognition provide safeguard；Secondly nonlinear dynamic analysis method is used, it will be real-time
EEG signals calculate the EEG signals characteristic values such as dynamic Lempel-Ziv complexity, C0 complexity and entropy, these
After the clustered parser processing of brain electrical characteristic values, Classification and Identification finally is carried out using support vector machines, it is different by corresponding to
Control instruction.
Specifically in the present embodiment, the bluetooth unit uses TI instrument BLE-CC2640R2F chip, for receiving master
The EEG signals of unit transmission are controlled, and send personalized audiovisual stimulating apparatus for the EEG signals.
Wherein, bluetooth CC2640R2F chip is applicable to4.2 and Bluetooth, 5 low-power consumption application,
It is a wireless microcontroller, and there is peripheral functionality collection abundant, integrated temperature sensor, duration compares device, surpasses
Low-power consumption analog comparator etc., including a unique super low-power consumption sensor controller, this sensor is suitble to connection outer
Portion's sensor, and analog- and digital- data, institute can be independently collected in the case where system rest part is in sleep pattern
To be capable of the eeg data of real-time Transmission patient, if while external brain wave acquisition device do not carry out signal acquisition, bluetooth is automatic
Into sleep state.Therefore, CC2640R2F device is as data transmission module, long, the low in energy consumption, body with battery
The advantages that product is small.
Specifically in the present embodiment, the consciousness assessment function of disturbance of consciousness person is based on Electrophysiology detection technique (EEG/
ERP), Functional magnetic resonance imaging (fMRI), Positron Emission Computed Tomography technology (PET) and clinical behavior amount
The multi-modal integrated database of table.
Specifically in the present embodiment, described through cranium galvanic current stimulation device, using fpga chip (Field
Programmable Gate Array, field programmable gate array), personalized audiovisual thorn is adjusted according to real-time brain electrical characteristic values
Hormone material and stimulus type through cranium galvanic current stimulation, output direct current electric strength, realize the adaptive of disturbance of consciousness therapeutic scheme
It adjusts.
Embodiment three
Present embodiment discloses a kind of based on the detection of the biofeedback type disturbance of consciousness, wakes up the working method of system, comprising:
Step 1: personalized audiovisual stimulating apparatus carries out consciousness stimulation to disturbance of consciousness person；
Step 2: integrated simulation front end connection brain wave acquisition device acquires disturbance of consciousness person's EEG signals；
Step 3: above-mentioned signal is received by main control unit, handles to obtain brain electrical characteristic values and stored；
Step 4: being wirelessly transmitted to personalized audiovisual by bluetooth unit stimulates by the brain electrical characteristic values in above-mentioned steps
Device；
Step 5: the brain electrical characteristic values in above-mentioned steps are combined the multi-modal comprehensive number in personalized audiovisual stimulating apparatus
According to library, the state of consciousness of disturbance of consciousness person is fully assessed；
Step 6: dynamic regulation personalization audiovisual stimulates the combination of material according to the real-time assessment result in above-mentioned steps
Time and stimulus type, output direct current electric strength through cranium galvanic current stimulation is presented in mode, automatic adjusument disturbance of consciousness person's
Wake-up scheme.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (9)
1. a kind of biofeedback type disturbance of consciousness detection and wake-up system, which is characterized in that the system includes personalized view
It listens stimulating apparatus, disturbance of consciousness evaluation module and through cranium galvanic current stimulation device, the disturbance of consciousness evaluation module includes brain
Electric collector, integrated simulation front end, main control unit, bluetooth unit, Power Management Unit, wherein the brain wave acquisition device is logical
It crosses electrode and USB interface to be connected with integrated simulation front end, the integrated simulation front end is connected by SPI with main control unit, institute
The main control unit stated is connected by UART with the bluetooth unit, and the bluetooth unit and the personalized audiovisual stimulate
The eeg data of main control unit is transferred to personalized audiovisual by bluetooth unit and is pierced by device by bluetooth wireless information interaction
Excitation device controls different personalized audiovisual stimulation protocols,
Described connect through cranium galvanic current stimulation device with the main control unit, is adjusted according to the brain electrical characteristic values of main control unit
Personalized audiovisual stimulates material and stimulus type, output direct current electric strength through cranium galvanic current stimulation, wherein described straight through cranium
The stimulus type of galvanic shock includes stimulus of direct current, impulse stimulation, sinusoidal stimulation and pseudo- stimulation.
2. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Personalized audition stimulation protocol designed based on psychological principle, by collecting and screening disturbance of consciousness person's relevant memory letter
Breath selects optimal light, sound, the combination of shadow and presentation time, wherein recall info includes that disturbance of consciousness person most likes
, the most deep people of memory, object, thing.
3. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Disturbance of consciousness evaluation module further include Power Management Unit, the Power Management Unit be integrated simulation front end, master control list
Member is powered through cranium galvanic current stimulation device.
4. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Brain wave acquisition device include cap, monopole eeg sensor, reference electrode, wherein the described monopole eeg sensor setting exists
The inside of cap, and the forehead skin contact with wearer；The reference electrode is connected with the lower edge of cap, and is clipped in wearing
At the ear-lobe of person；The reference electrode is brain electricity patch electrode；
The monopole eeg sensor and reference electrode are connect with integrated simulation front end respectively.
5. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Integrated simulation front end select the ADS1299 chip of TI company, including sequentially connected multiplexer, detection components, filtering
Device, low noise gain amplifier, high-resolution analog-digital converter, biasing driving amplifier, oscillator and Serial Peripheral Interface (SPI)
SPI,
Collected EEG signals are amplified, filter and analog-to-digital conversion after master control is transferred to by serial peripheral equipment interface SPI
Unit.
6. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Include D/A converter module, constant current source module and surface electrode through cranium galvanic current stimulation device, this is through cranium galvanic current stimulation
Device exports stimulus of direct current, impulse stimulation, sinusoidal stimulation and pseudo- stimulation, the stimulation of output according to the brain electrical characteristic values of main control unit
Signal, through constant current source module, suitable electric current is exported to surface electrode after D/A converter module carries out digital-to-analogue conversion, and
Act on disturbance of consciousness person's target region.
7. a kind of biofeedback type disturbance of consciousness detection according to claim 6 and wake-up system, which is characterized in that described
Further include current foldback circuit for limiting circuit transient current through cranium galvanic current stimulation device, the overcurrent protection electricity
Road includes NPN type triode T1, sampling resistor R1, pull-up resistor R2, FPGA and capacitor C1, wherein the one of NPN type triode T1
The pole N is connected with pull-up resistor R2 and FPGA respectively, another pole N ground connection of NPN type triode T1, the pole P of NPN type triode T1
It is grounded after being connected respectively with sampling resistor R1 and capacitor C1；Protecting signal is the input signal of current foldback circuit, and input is adopted
One end of sample resistance R1 and capacitor C1；
When protecting signal code excessive, capacitor C1 slowly charges, and sampling resistor R1 generates high partial pressures, NPN type triode T1 quilt
Conducting exports high level, controls the output of stimulus waveform, have the function that current limliting with this through pull-up resistor R2, FPGA.
8. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Main control unit carry out EEG Processing, first using wavelet package transforms eliminate low frequency noises, be then based on maximum letter
It makes an uproar the blind source separation algorithm of ratio, the artefact for EEG signals is filtered；Secondly nonlinear dynamic analysis method is used, it will
Real-time EEG signals calculate the EEG signals including dynamic Lempel-Ziv complexity, C0 complexity and entropy
Characteristic value finally carries out Classification and Identification using support vector machines after the clustered parser processing of above-mentioned brain electrical characteristic values, right
It should obtain different control instructions.
9. a kind of biofeedback type disturbance of consciousness detection according to claim 1 and wake-up system, which is characterized in that described
Bluetooth unit use TI instrument BLE-CC2640R2F chip.
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