CN108982825A - A kind of helicobacter pylori detection kit and detection method - Google Patents
A kind of helicobacter pylori detection kit and detection method Download PDFInfo
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- CN108982825A CN108982825A CN201810447937.1A CN201810447937A CN108982825A CN 108982825 A CN108982825 A CN 108982825A CN 201810447937 A CN201810447937 A CN 201810447937A CN 108982825 A CN108982825 A CN 108982825A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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Abstract
The invention discloses a kind of helicobacter pylori detection kit and detection method, step includes: 1) to number four exhaust tubes, and each exhaust tube installs air blowing filter tip；2) the first sealant, the second sealant, third sealant are broken, flows into liquid in the space below third partition by through-hole, be uniformly mixed drug；3) function button is pressed, pressure inductor, pressure value when setting warning lamp flashes are opened, person to be detected on an empty stomach exhales to No. 1 and No. 2, is sealed；4) drug is sucked using suction pipe, opens timer, and the flashing of time warning lamp is set, sat quietly and wait 30min；5) it when warning lamp flashing, exhales, is sealed to No. 3 and No. 4；6) gas in 4 gas collection bags is taken to be detected.The present invention will test reagent that helicobacter pylori to be used by simple structure and capturing material all includes, and it is convenient to operate, can be stronger with generalization, is suitable for industrialized production.
Description
Technical field
The present invention relates to pharmaceutical technology field more particularly to a kind of helicobacter pylori detection kits and detection method.
Background technique
Helicobacter pylori (HelicobacterPylori, abbreviation HP) be a kind of more flagellums for living in people's stomach lining,
Spiral gramnegative bacterium.Nineteen eighty-three Australian Scientists Marshall and Warren are for the first time from chronic active stomach
It is successfully separated helicobacter pylori in scorching patient's Gastric Biopsy, and because they do in helicobacter pylori research field
Contribution out, and obtain Nobel's physiology Medicine in 2005.Helicobacter pylori is obligate micro- aerobic, growing nutrient requirement
Height, and slow growth, it usually needs 3~5 talentes form bacterium colony, have stronger tolerance than general bacterium to low PH.HP is to Weishang
Chrotoplast has a special compatibility, and under natural conditions, it is small that a large amount of HP mainly appear on gastric epithelial cell surface, space between cells and stomach
In recessed.
HP infection has world wide, and epidemiological study shows that the mankind are susceptible to HP, HP infection and age, area,
The many factors such as ethnic group, socioeconomic status, sanitary condition, population density, eating habit are related.Socioeconomic status is got over
Good, GDP higher countries and regions, HP infection rate are lower；Densely populated degree is bigger, and HP infection rate is higher.Developing country
Generally higher than developed country, up to 80~90%, developed country's infection rate is 38~40%；Developing country's childhood infection rate can
Up to 80% or more, the age of infection is mostly before 3~5 years old；The corresponding age childhood infection rate of developed country is lower, insufficient
10%, but with age, HP infection is in rising trend.
Helicobacter pylori has very strong activity and fertility, is a kind of bacterium for seriously affecting public health.From
Since finding HP for the first time from nineteen eighty-three Warren et al., an important factor for HP has been acknowledged as disease of upper digestive tract.Largely
Research data shows that HP is the pathogen of chronic active gastritis, is the important virulence factor and gastric mucosa of peptic ulcer
The important virulence factor of associated lymphoid tissue (MALT) lymthoma.Researcher also sends out in the research to HP and gastric cancer correlation
It is existing, infect that the ratio to get a cancer of the stomach in the crowd of HP is obviously higher than control group, so that prompting HP may be lead to gastric cancer carcinogenic
The factor.In the indigestion patient of non-ulcerative, also have 40-70% that can detect HP, but relationship between the two need into
One step confirmation.On the other hand, the therapeutic scheme of HP is complicated, and short run effect is good, but still has a possibility that recurrence.And early diagnosis therefore
Disconnected HP, it is significant to prevention and treatment disease of upper digestive tract.A kind of helicobacter pylori detection kit and detection side are proposed thus
Method.
Summary of the invention
The purpose of the present invention is to solve the complex disadvantages of inspection program in the prior art, and the one kind proposed is deep and remote
Door pylori detection kit and detection method.
To achieve the goals above, present invention employs following technical solutions:
A kind of helicobacter pylori detection kit, including reagent box body are designed, is fixedly connected with first partition in kit body,
First partition is vertically arranged, and kit internal body portion is divided into the first cavity and the second cavity, the first inside cavity by first partition
The second partition being vertically arranged by three is separated into four third chambers, and the inner bottom wall of each third chamber is fixedly connected with
There is pressure inductor, the roof of each third chamber, which runs through, is connected with exhaust tube, and exhaust tube is located at third chamber indoor one
End is fixedly connected with gas collection bag；
Third partition is fixedly connected with inside second chamber, third partition is horizontally disposed, through-hole is offered in the middle part of third partition, the
Three partition upper surfaces are vertically connected with liquid container pipe, and the diameter of liquid container pipe is greater than through-hole diameter, and liquid container pipe position
Right above through-hole, the liquid container pipe other end reaches outside through roof in second chamber, and liquid container bottom of the tube is fixed to be connected
It is connected to third sealant, is fixedly connected with the second sealant in the middle part of liquid container pipe, liquid container pipe top is fixedly connected with the
Three sealants are equipped between the first sealant and the second sealant and contain13C- urea liquid, the second sealant and third sealant
Between be equipped with citric acid solution；
Sweetener is housed below third partition；Stirring rod is equipped with below third partition, the other end of stirring rod sequentially passes through third
Partition, second chamber roof reach external；
Second chamber inner wall is fixedly connected with the 4th partition, and the 4th partition is located above third partition, third partition and the second chamber
Suction pipe is equipped in the cavity that chamber interior walls are formed, reagent box body upper surface is fixedly connected with timer, and timer side is equipped with function
Key, function button side are fixedly connected with warning lamp.
Preferably, gas collection bag bottom is fixedly connected with support chip.
Preferably, exhaust tube is located at third exterior thereto threaded one end and is connected with air blowing filter tip, matching at the top of air blowing filter tip
Equipped with sealing cover.
Preferably, one end of suction pipe is fixedly connected with syringe needle.
Preferably, the first sealant, the second sealant, third sealant manufacture material be aluminium foil.
The present invention also provides a kind of detection methods of helicobacter pylori detection kit, comprising the following steps:
It 1) is 1,2,3,4, No. 1 and No. 2 for control group by four exhaust tubes number, No. 3 and No. 4 are experimental group, and each is exhaled
Tracheae installs air blowing filter tip；
2) the first sealant, the second sealant, third sealant are broken, flows into liquid below third partition by through-hole
In space, stirring rod is rotated, is uniformly mixed drug；
3) function button is pressed, opens pressure inductor, pressure value when setting warning lamp flashes, person to be detected is on an empty stomach to No. 1
It exhales with No. 2, is then sealed；
4) drug is sucked using suction pipe, opens timer, and the flashing of time warning lamp is set, sat quietly and wait 30min；
5) it when warning lamp flashing, exhales to No. 3 and No. 4, is then sealed；
6) gas in 4 gas collection bags is taken to be detected.
A kind of helicobacter pylori detection kit and detection method, beneficial effect proposed by the present invention are: the present invention
The pressure inductor of middle setting and the support chip being equipped with, warning lamp more can intuitively show that gas collecting amount reaches
It is required that signal.
The timer of setting and the warning lamp being equipped with can understand drug clothes convenient for person to be detected and inspection personnel
It is more accurate with the waiting time later, and avoid the waiting time it is inaccurate caused by testing result inaccuracy situation.
The first sealant being arranged inside liquid container pipe, the second sealant and third sealant and third partition, will
Each section detection reagent is separated, saves the drug performance of each section reagent to the greatest extent, guarantees detection effect
It is optimal.
The present invention will test the reagent and capturing material whole that helicobacter pylori to be used by simple structure
Including, it is convenient to operate, can be stronger with generalization, it is suitable for industrialized production.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention.
Fig. 2 is schematic top plan view of the invention.
Fig. 3 is suction-pipe structure schematic diagram of the invention.
In figure: 1- reagent box body, 2- first partition, 3- second partition, 4- exhaust tube, 5- gas collection bag, 6- support chip,
7- pressure inductor, 8- air blowing filter tip, 9- third partition, 10- stirring rod, 11- liquid container pipe, the first sealant of 12-, 13-
Second sealant, 14- third sealant, the 4th partition of 15-, 16- suction pipe, 17- timer, 18- function button, 19- warning lamp.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1-3, a kind of helicobacter pylori detection kit, including reagent box body 1, it is fixed in reagent box body 1 to connect
It is connected to first partition 2, first partition 2 is vertically arranged, and first partition 2 will be separated into the first cavity and second inside reagent box body 1
Cavity, the first inside cavity are separated into four third chambers by three second partitions 3 being vertically arranged, each third chamber
Inner bottom wall be fixedly connected to pressure inductor 7, the roof of each third chamber, which runs through, is connected with exhaust tube 4, exhale
Pipe 4 is located at the indoor one end of third chamber and is fixedly connected with gas collection bag 5, and 5 bottom of gas collection bag is fixedly connected with support chip
6。
Third partition 9 is fixedly connected with inside second chamber, third partition 9 is horizontally disposed, offers in the middle part of third partition 9
Through-hole, 9 upper surface of third partition are vertically connected with liquid container pipe 11, and the diameter of liquid container pipe 11 is greater than through-hole diameter, and
Liquid container pipe 11 is located at right above through-hole, and 11 other end of liquid container pipe reaches external, liquid through roof in second chamber
11 bottom of container tube is fixedly connected with third sealant 14, and the second sealant 13, liquid are fixedly connected in the middle part of liquid container pipe 11
11 top of body container tube is fixedly connected with third sealant 14, the first sealant 12, the second sealant 13, third sealant 14
Manufacture material is aluminium foil, is equipped with and contains between the first sealant 12 and the second sealant 1313C- urea liquid, the second sealant
Citric acid solution is housed between 13 and third sealant 14.
Sweetener is housed below third partition 9；Be equipped with stirring rod 10 below third partition 9, the other end of stirring rod 10 according to
It is secondary to reach outside through third partition 9, second chamber roof.
Second chamber inner wall is fixedly connected with the 4th partition 15, and the 4th partition 15 is located at 9 top of third partition, third partition
It is equipped with suction pipe 16 in 9 cavitys formed with second chamber inner wall, one end of suction pipe 16 is fixedly connected with syringe needle 20, reagent box body 1
Upper surface is fixedly connected with timer 17, and 17 side of timer is equipped with function button 18, and 18 side of function button is fixedly connected with
Warning lamp 19.
Exhaust tube 4 is located at third exterior thereto threaded one end and is connected with air blowing filter tip 8, matches and is equipped at the top of air blowing filter tip 8
Sealing cover.
A kind of detection method according to helicobacter pylori detection kit, comprising the following steps:
It 1) is 1,2,3,4, No. 1 and No. 2 for control group by four exhaust tubes 4 number, No. 3 and No. 4 are experimental group, and each is exhaled
Tracheae 4 installs air blowing filter tip 8；
2) the first sealant 12, the second sealant 13, third sealant 14 are broken, liquid is made to flow into third partition by through-hole
In the space of 9 lower sections, stirring rod 10 is rotated, is uniformly mixed drug；
3) function button 18 is pressed, opens pressure inductor 7, pressure value when setting warning lamp 19 flashes, person to be detected is on an empty stomach
It exhales to No. 1 and No. 2, is then sealed；
4) drug is sucked using suction pipe 16, opens timer 17, and the flashing of time warning lamp 19 is set, sat quietly and wait 30min；
5) it when the flashing of warning lamp 19, exhales to No. 3 and No. 4, is then sealed；
6) gas in 4 gas collection bags 5 is taken to be detected.
More than, it is merely preferred embodiments of the present invention, but scope of protection of the present invention is not limited thereto, it is any
Those familiar with the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its invents
Design is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of helicobacter pylori detection kit, including reagent box body (1), it is characterised in that: in the reagent box body (1)
It is fixedly connected with first partition (2), the first partition (2) is vertically arranged, and the first partition (2) will be in reagent box body (1)
Part is divided into the first cavity and the second cavity, and the second partition (3) that first inside cavity is vertically arranged by three separates
At four third chambers, the inner bottom wall of each third chamber is fixedly connected to pressure inductor (7), described in each
The roof of third chamber, which runs through, to be connected with exhaust tube (4), and the exhaust tube (4) is located at the indoor one end of third chamber and is fixedly connected
There are gas collection bag (5)；
Be fixedly connected with inside the second chamber third partition (9), the third partition (9) is horizontally disposed, the third every
Through-hole is offered in the middle part of plate (9), third partition (9) upper surface is vertically connected with liquid container pipe (11), and the liquid holds
The diameter of device pipe (11) is greater than through-hole diameter, and liquid container pipe (11) is located at right above through-hole, the liquid container pipe (11)
The other end reaches outside through roof in second chamber, and liquid container pipe (11) bottom is fixedly connected with third sealant
(14), it is fixedly connected with the second sealant (13) in the middle part of the liquid container pipe (11), liquid container pipe (11) top is solid
Surely it is connected with third sealant (14), is equipped with and contains between first sealant (12) and the second sealant (13)13C- urea
Solution is equipped with citric acid solution between second sealant (13) and third sealant (14)；
Sweetener is housed below the third partition (9), is equipped with stirring rod (10) below the third partition (9), the stirring
The other end of bar (10) sequentially passes through third partition (9), second chamber roof reaches outside；
The second chamber inner wall is fixedly connected with the 4th partition (15), and the 4th partition (15) is located on third partition (9)
Suction pipe (16) are equipped in the cavity that side, the third partition (9) and second chamber inner wall are formed, reagent box body (1) upper end
Face is fixedly connected with timer (17), and timer (17) side is equipped with function button (18), the function button (18) one
Side is fixedly connected with warning lamp (19).
2. a kind of helicobacter pylori detection kit according to claim 1, it is characterised in that: the gas collection bag
(5) bottom is fixedly connected with support chip (6).
3. a kind of helicobacter pylori detection kit according to claim 1, it is characterised in that: the exhaust tube (4)
It is connected with air blowing filter tip (8) positioned at third exterior thereto threaded one end, matching is equipped with sealing cover at the top of the air blowing filter tip (8).
4. a kind of helicobacter pylori detection kit according to claim 1, it is characterised in that: the suction pipe (16)
One end is fixedly connected with syringe needle (20).
5. a kind of helicobacter pylori detection kit according to claim 1, it is characterised in that: first sealant
(12), the second sealant (13), third sealant (14) manufacture material be aluminium foil.
6. a kind of detection method of helicobacter pylori detection kit according to claim 1, it is characterised in that: including
Following steps:
It 1) is 1,2,3,4, No. 1 and No. 2 for control group by four exhaust tubes (4) number, No. 3 and No. 4 are experimental group, and each
Exhaust tube (4) installs air blowing filter tip (8)；
2) the first sealant (12), the second sealant (13), third sealant (14) are broken, liquid is made to flow into the by through-hole
It in space below three partitions (9), rotates stirring rod (10), is uniformly mixed drug；
3) it presses function button (18), opens pressure inductor (7), pressure value when setting warning lamp (19) flashes is to be detected
Person on an empty stomach exhales to No. 1 and No. 2, is then sealed；
4) drug is sucked using suction pipe (16), is opened timer (17), and time warning lamp (19) flashing, waiting of sitting quietly are set
30min；
5) it when warning lamp (19) flashing, exhales to No. 3 and No. 4, is then sealed；
6) gas in 4 gas collection bags (5) is taken to be detected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810447937.1A CN108982825A (en) | 2018-05-11 | 2018-05-11 | A kind of helicobacter pylori detection kit and detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810447937.1A CN108982825A (en) | 2018-05-11 | 2018-05-11 | A kind of helicobacter pylori detection kit and detection method |
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| Publication Number | Publication Date |
|---|---|
| CN108982825A true CN108982825A (en) | 2018-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810447937.1A Pending CN108982825A (en) | 2018-05-11 | 2018-05-11 | A kind of helicobacter pylori detection kit and detection method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110988319A (en) * | 2019-12-20 | 2020-04-10 | 无锡市尚沃医疗电子股份有限公司 | Expiration detection method and device for pyloric screw infection and related inflammation |
| CN111624355A (en) * | 2020-06-10 | 2020-09-04 | 波音特生物科技（南京）有限公司 | Diagnostic kit easy for mass screening for insulin detection |
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| US20050084977A1 (en) * | 2003-10-16 | 2005-04-21 | Kimberly-Clark Worldwide, Inc. | Method and device for detecting ammonia odors and helicobacter pylori urease infection |
| CN101231284A (en) * | 2007-01-23 | 2008-07-30 | 张厚德 | Urea kit for diagnosing pylorus helicobacterium infestation |
| JP2015102414A (en) * | 2013-11-25 | 2015-06-04 | 後藤 利夫 | Detection method and tool of helicobacter pylori |
| WO2015179755A1 (en) * | 2014-05-22 | 2015-11-26 | Anastasia Rigas | Breath analyzer and breath test method |
| EP3009838A1 (en) * | 2014-10-17 | 2016-04-20 | Sitke Dr. Aygen | A breath test for the diagnosis of helicobacter pylori infection |
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2018
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006766A2 (en) * | 2002-07-12 | 2004-01-22 | Baxter International Inc. | Method and apparatus for the detection of the presence of a bacteria in the gastrointestinal tract of a subject |
| US20050084977A1 (en) * | 2003-10-16 | 2005-04-21 | Kimberly-Clark Worldwide, Inc. | Method and device for detecting ammonia odors and helicobacter pylori urease infection |
| CN101231284A (en) * | 2007-01-23 | 2008-07-30 | 张厚德 | Urea kit for diagnosing pylorus helicobacterium infestation |
| JP2015102414A (en) * | 2013-11-25 | 2015-06-04 | 後藤 利夫 | Detection method and tool of helicobacter pylori |
| WO2015179755A1 (en) * | 2014-05-22 | 2015-11-26 | Anastasia Rigas | Breath analyzer and breath test method |
| EP3009838A1 (en) * | 2014-10-17 | 2016-04-20 | Sitke Dr. Aygen | A breath test for the diagnosis of helicobacter pylori infection |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110988319A (en) * | 2019-12-20 | 2020-04-10 | 无锡市尚沃医疗电子股份有限公司 | Expiration detection method and device for pyloric screw infection and related inflammation |
| CN111624355A (en) * | 2020-06-10 | 2020-09-04 | 波音特生物科技（南京）有限公司 | Diagnostic kit easy for mass screening for insulin detection |
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Application publication date: 20181211 |