CN108980459A - A kind of micro-fluidic chip detection microfluidic valve valve group - Google Patents
A kind of micro-fluidic chip detection microfluidic valve valve group Download PDFInfo
- Publication number
- CN108980459A CN108980459A CN201810972095.1A CN201810972095A CN108980459A CN 108980459 A CN108980459 A CN 108980459A CN 201810972095 A CN201810972095 A CN 201810972095A CN 108980459 A CN108980459 A CN 108980459A
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- Prior art keywords
- valve
- micro
- drawstring
- fluidic chip
- microfluidic
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indication Of The Valve Opening Or Closing Status (AREA)
- Magnetically Actuated Valves (AREA)
Abstract
The present invention relates to a kind of micro-fluidic chip detection microfluidic valve valve groups.Micro-fluidic chip detection microfluidic valve valve group includes pedestal, position is adjustable in the horizontal plane on pedestal is equipped at least two microfluidic valves, each microfluidic valve respectively includes valve body and reciprocating movement is assemblied in the spool that the microchannel on-off of corresponding micro-fluidic chip is controlled on valve body, drawstring is connected on spool, it is connected with drawstring traction mechanism on drawstring, is additionally provided in the valve body to spool and applies elastic acting force to drive the elastic component of the spool reciprocating action with drawstring cooperation.The present invention solve the problems, such as existing pneumatic type microfluidic valve occupy that volume is big and electromagnetic type microfluidic valve to be arranged in calorific value below micro-fluidic chip big, position of at least two microfluidic valves of microfluidic valve valve group of the invention simultaneously on pedestal is adjustable, so that the position by adjusting microfluidic valve is applicable to different micro-fluidic chips, there is preferable versatility.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip detection microfluidic valve valve groups.
Background technique
Microfluidic valve is the critical function unit for realizing microfluidic channel open and close control, is to guarantee micro-fluidic detection system just
One of key factor often run.Currently used microfluidic valve mainly has pneumatic type and electromagnetic type, pneumatic type microfluidic valve gas
Line structure is more complex, processing difficulties and needs to connect external air source, it is difficult to realize the miniaturization of micro-fluidic detection system；Conventional electricity
The electromagnetic component of magnetic-type microfluidic valve is normally at the lower part of micro-fluidic chip, and has biggish fever when electromagnetic component work
Effect, will generate certain influence to micro-fluidic chip, and conventional electromagnetic declines that flow control valve arrangement is larger, and settable is micro-fluidic
Valve negligible amounts.In addition, multiple microfluidic valves are often directly fixed on micro-fluidic chip by current micro-fluidic detection system
Lower section, the quantity of microfluidic valve and position are difficult to change, and are only applicable to the micro-fluidic chip of certain fixing model, poor universality.
Summary of the invention
The purpose of the present invention is to provide a kind of general micro-fluidic chip detection microfluidic valve valve groups, solve existing
Microfluidic valve is directly fixed on the problem of leading to poor universality below micro-fluidic chip.
To achieve the above object, micro-fluidic chip detection of the invention is with the technical solution of microfluidic valve valve group:
Micro-fluidic chip detection microfluidic valve valve group includes pedestal, and position is adjustable in the horizontal plane on pedestal is equipped at least
Two microfluidic valves, each microfluidic valve respectively includes valve body and reciprocating movement is assemblied on valve body to control corresponding micro-fluidic chip
Microchannel on-off spool, be connected with drawstring on spool, drawstring traction mechanism be connected on drawstring, is also set in the valve body
It is equipped with to spool and applies elastic acting force to drive the elastic component of the spool reciprocating action with drawstring cooperation.
The utility model has the advantages that the microfluidic valve in micro-fluidic chip detection microfluidic valve valve group of the invention is towed miniflow
Valve is controlled, existing pneumatic type microfluidic valve occupancy volume is solved greatly and electromagnetic type microfluidic valve is arranged in below micro-fluidic chip
The big problem of calorific value, while position of at least two microfluidic valves of microfluidic valve valve group of the invention on pedestal is adjustable,
So that the position by adjusting microfluidic valve is applicable to different micro-fluidic chips, there is preferable versatility.
Further, defining two perpendicular directions on pedestal is X-direction and Y-direction, and position can in X direction on pedestal
That adjusts is provided with mounting rack, and each microfluidic valve is assemblied on the mounting rack along the direction Y position is adjustable.Microfluidic valve is logical
Mounting rack is crossed to be mounted on the base convenient for microfluidic valve installation.
Further, the mounting rack is provided at least two, has on each mounting rack at least two described micro-fluidic
Valve.Mounting rack at least two, at least two microfluidic valves help to control the microchannel of micro-fluidic chip on each mounting rack.
Further, the pedestal is inverted U-shaped frame structure, and the mounting rack is located in the horizontal sides of inverted U-shaped frame, drawstring
Traction mechanism is located on the lateral surface of the vertical edge of inverted U-shaped frame.Help so that microfluidic valve valve block structure is more compact.
Further, the position of the drawstring traction mechanism in the Y direction is adjustable.Drawstring traction mechanism is upper in the Y direction
Set the adjustable drawstring traction mechanism horizontally tracting drawstring that enables.
Further, the drawstring traction mechanism is electromagnetic drag mechanism, and the electromagnetic drag mechanism includes guiding activity
The armature that is assemblied on pedestal and with armature with the use of the electromagnet to realize spool reciprocating action, the drawstring is connected to
On the armature.Electromagnetic drag mechanism is convenient for control.
Further, the armature has the perforation passed through for drawstring, and there is releasable connection on the armature is pierced by drawstring
The drawstring in perforation is pressed on the fastener on perforation hole wall after perforation.The length of adjustable drawstring.
Detailed description of the invention
Fig. 1 is the structural schematic diagram that microfluidic valve valve group is used in micro-fluidic chip detection of the invention；
Fig. 2 is the structural schematic diagram of the microfluidic valve in micro-fluidic chip detection microfluidic valve valve group of the invention；
Fig. 3 is the structural schematic diagram of the pedestal in micro-fluidic chip detection microfluidic valve valve group of the invention；
Fig. 4 is the structural schematic diagram of the mounting rack in micro-fluidic chip detection microfluidic valve valve group of the invention；
Fig. 5 is the structural schematic diagram of the armature in micro-fluidic chip detection microfluidic valve valve group of the invention；
Fig. 6 is the structural schematic diagram of the electromagnet in micro-fluidic chip detection microfluidic valve valve group of the invention；
In attached drawing: 1, valve head；2, spool；3, valve body；4, spring；5, elbow；6, drawstring；7, fixing seat；8, screw；9, armature；
91, pilot hole；92, screw hole；93, it perforates；94, pressuring line groove；10, pedestal；101, mounting rack mounting hole；102, fixing seat is installed
Hole；11, mounting rack；111, microfluidic valve mounting hole；112, fixation hole；12, electromagnet；121, pilot hole；13, microfluidic valve.
Specific embodiment
Embodiments of the present invention are described further with reference to the accompanying drawing.
The micro-fluidic chip detection of the invention specific embodiment one of microfluidic valve valve group, as shown in Figures 1 to 6, packet
Pedestal 10 is included, pedestal 10 is inverted U shape frame structure, and defining direction perpendicular on pedestal 10 is the X-direction (pedestal 10 in Fig. 3
Left and right directions) and Y-direction (front-rear direction of the pedestal 10 in Fig. 3).Have in X direction in the horizontal sides of inverted U-shaped pedestal 10
Adjustable two mounting racks 11 in position, in other embodiments, the quantity of mounting rack 11 can according to need any setting.Each peace
Shelving installation on 11, there are two microfluidic valves 13, and microfluidic valve 13 is adjustable along Y-direction position on mounting rack 11, other embodiments
In, the quantity of the microfluidic valve on each mounting rack 11 can according to need any setting.
Specifically, the mounting rack 11 in the present embodiment is bolted to connection with pedestal 10, the mounting rack on pedestal 10
Mounting hole 101 is the long hole extended in X direction, and the fixation hole 112 on mounting rack is circular hole, to realize mounting rack 11 in pedestal
Position is adjustable in X direction on 10.Microfluidic valve is mounted on mounting rack 11 by screw, the microfluidic valve installation on mounting rack 11
Hole 111 is the long hole extended along Y-direction, to realize that microfluidic valve is adjustable along Y-direction position on mounting rack 11.To make difference
The microfluidic valve of size can be mounted on mounting rack 11, and the mounting rack 11 in the present embodiment includes left stretcher body and right stretcher body, left,
The microfluidic valve mounting hole 111 extended along Y-direction is provided on right stretcher body, microfluidic valve 13 is fixedly clamped by left and right frame body.
Referring to Fig. 2, the microfluidic valve 13 in the present embodiment is towed microfluidic valve, and towed microfluidic valve 13 includes valve
Body 3 and reciprocating movement are assemblied in the spool 2 in valve body 3, and spool 2 includes the valve with the cooperation of the microchannel of corresponding micro-fluidic chip
First 1, drawstring 6 is connected on spool 2, is additionally provided in valve body 3 and is applied elastic acting force to spool 2 and driven with cooperating with drawstring 6
The elastic component of 2 reciprocating action of spool, the elastic component in the present embodiment are spring 4.The lower end of valve body 3 is additionally provided with for drawstring
6 elbows 5 being pierced by, elbow 5 are horizontally extending for the outlet end of arcuate structure and elbow 5.
The drawstring traction mechanism for pulling drawstring 6, drawstring traction mechanism and microfluidic valve 13 are additionally provided on pedestal 10
It corresponds.Fixing seat 7, consolidating on pedestal 10 have been bolted on the lateral surface of two vertical edges of inverted U-shaped pedestal 10
Reservation mounting hole 102 is the long hole extended along Y-direction, to realize that position of the fixing seat 7 in the Y-direction of pedestal 10 is adjustable.
There are two screw rods disposed in parallel for the side tool of fixing seat 7, and one end that screw rod penetrates in fixing seat mounting hole 102 is provided with outer spiral shell
Line cooperates on external screw thread with nut and fixing seat 7 is pressed on pedestal 10, and fixing seat 7 has between two screw rods for supplying
The through hole that drawstring 6 passes through.There are two guiding axis disposed in parallel away from the side tool of setting screw rod for fixing seat 7, run through hole location
Between two guiding axis.Guiding is equipped with armature 9 in fixing seat 7, and there are two for being sleeved on two guiding axis for tool on armature 9
On pilot hole 91, there is on the armature 9 between two pilot holes 91 perforation 93 for passing through for drawstring 6, perforate 93 one
Holding has the pressuring line groove 94 that extends downwardly, and the upper surface of armature 9 has be connected to perforation and will perforate 93 for cooperating with fastener
Interior drawstring 6 is pressed on the screw hole 92 on perforation hole wall, and the fastener in the present embodiment is the screw 8 cooperated with screw hole 92.It draws
6 traction mechanisms of restricting further include the electromagnet 12 for cooperating traction drawstring 6 to realize that spool 2 moves back and forth in valve body 3 with armature 9, electricity
There are two the pilot holes 121 being adapted to guiding axis towards the side of armature 9 tool for magnet 12.
Micro-fluidic chip detection microfluidic valve valve group in the present embodiment is in use, microfluidic valve valve group is arranged in miniflow
Control chip underside, micro-fluidic chip is by PMMA (organic glass), the PDMS(organosilicon being bonded with PMMA), the microfluid in PMMA
Channel composition.When electromagnet 12 is not powered on, the spool 2 of microfluidic valve is under the elastic force effect of spring 4 and on micro-fluidic chip
Microchannel block so that microchannel is in closed state；After electromagnet 12 is powered, the spool 2 of microfluidic valve is in electromagnet
It is opened under the action of 12, spool 2 is detached from PDMS film, microfluidic channel connection.When another different micro-fluidic for detecting
When chip, adjustable mounting rack 11 the position of position and microfluidic valve on mounting rack 11 on pedestal 10 with realize with it is micro-
Fluidic chip adaptation.
The micro-fluidic chip detection of the invention specific embodiment two of microfluidic valve valve group, detects with micro-fluidic chip and uses
Microfluidic valve valve group embodiment one the difference is that, the bolt for being connect with pedestal on the mounting rack in the present embodiment
Perforation is long hole, other are the same as example 1, and repeat no more.
The micro-fluidic chip detection of the invention specific embodiment three of microfluidic valve valve group, detects with micro-fluidic chip and uses
Microfluidic valve valve group embodiment one the difference is that, there is the sliding slot that extends in X direction, peace on the pedestal in the present embodiment
It shelves and is slidedly assemblied in sliding slot, there is the jackscrew for locking mounting rack when mounting rack is adjusted to required position on pedestal,
In other embodiments, there is spring catch on mounting rack, there are on pedestal the multiple fixation holes cooperated with spring catch, on mounting rack
Spring catch is by cooperating the position for realizing adjustment mounting rack on pedestal from different fixation holes.Other are the same as example 1, no
It repeats again.
The micro-fluidic chip detection of the invention specific embodiment four of microfluidic valve valve group, detects with micro-fluidic chip and uses
Microfluidic valve valve group embodiment one the difference is that, be provided on the mounting rack in the present embodiment for slidable fit miniflow
The sliding slot of valve is controlled, also there is the jackscrew for adjusting microfluidic valve position in sliding slot on mounting rack.Other and one phase of embodiment
Together, it repeats no more.
The micro-fluidic chip detection of the invention specific embodiment five of microfluidic valve valve group, detects with micro-fluidic chip and uses
Microfluidic valve valve group embodiment one the difference is that, the drawstring traction mechanism in the present embodiment includes telescoping cylinder, by stretching
The flexible pulling drawstring of contracting cylinder, in other embodiments, drawstring traction mechanism can also pass through motor driven.Other and embodiment one
It is identical, it repeats no more.
Claims (7)
1. micro-fluidic chip detection microfluidic valve valve group, it is characterised in that: including pedestal, position can in the horizontal plane on pedestal
That adjusts is equipped at least two microfluidic valves, and each microfluidic valve respectively includes valve body and reciprocating movement is assemblied on valve body to control
The spool of the microchannel on-off of corresponding micro-fluidic chip is connected with drawstring on spool, drawstring traction mechanism is connected on drawstring,
It is additionally provided in the valve body to spool and applies elastic acting force to drive the elasticity of the spool reciprocating action with drawstring cooperation
Part.
2. micro-fluidic chip detection microfluidic valve valve group according to claim 1, it is characterised in that: define two on pedestal
A perpendicular direction is X-direction and Y-direction, and position is adjustable in X direction on pedestal is provided with mounting rack, and each microfluidic valve is equal
It is assemblied on the mounting rack along the direction Y position is adjustable.
3. micro-fluidic chip detection microfluidic valve valve group according to claim 2, it is characterised in that: the installation is set up
At least two are equipped with, there are at least two microfluidic valves on each mounting rack.
4. micro-fluidic chip detection microfluidic valve valve group according to claim 2, it is characterised in that: the pedestal is to fall
U-shaped frame structure, the mounting rack are located in the horizontal sides of inverted U-shaped frame, and drawstring traction mechanism is located at the vertical edge of inverted U-shaped frame
On.
5. micro-fluidic chip detection microfluidic valve valve group according to claim 4, it is characterised in that: the drawstring traction
The position of mechanism in the Y direction is adjustable.
6. described in any item micro-fluidic chip detection microfluidic valve valve groups according to claim 1 ~ 5, it is characterised in that: described
Drawstring traction mechanism be electromagnetic drag mechanism, the electromagnetic drag mechanism include the armature that guiding activity is assemblied on pedestal and
With armature with the use of the electromagnet to realize spool reciprocating action, the drawstring is connected on the armature.
7. micro-fluidic chip detection microfluidic valve valve group according to claim 6, it is characterised in that: the armature has
For the perforation that drawstring passes through, on the armature, releasable connection, which has, is pressed on perforation for the drawstring in perforation after drawstring is pierced by perforation
Fastener on hole wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810972095.1A CN108980459B (en) | 2018-08-24 | 2018-08-24 | Micro-fluidic valve group for micro-fluidic chip detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810972095.1A CN108980459B (en) | 2018-08-24 | 2018-08-24 | Micro-fluidic valve group for micro-fluidic chip detection |
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| Publication Number | Publication Date |
|---|---|
| CN108980459A true CN108980459A (en) | 2018-12-11 |
| CN108980459B CN108980459B (en) | 2020-02-18 |
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| CN201810972095.1A Active CN108980459B (en) | 2018-08-24 | 2018-08-24 | Micro-fluidic valve group for micro-fluidic chip detection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111929460A (en) * | 2020-08-19 | 2020-11-13 | 河南科技大学 | Sampling, chip and liquid inlet control device suitable for microfluidic automatic detection |
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| CN107542973A (en) * | 2017-08-02 | 2018-01-05 | 南京岚煜生物科技有限公司 | Micro-fluidic chip and its application method with Locking type valve |
| CN206912545U (en) * | 2017-07-20 | 2018-01-23 | 无锡洲翔激光设备有限公司 | Robot welding positioner positioning plate device |
| CN107917194A (en) * | 2017-09-25 | 2018-04-17 | 温州诚博阀门有限公司 | A kind of line traffic control hydraulic control valve |
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| US20170151560A1 (en) * | 2004-10-13 | 2017-06-01 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
| JP2008039541A (en) * | 2006-08-04 | 2008-02-21 | National Institute For Materials Science | Microflow channel chip and biological polymer treatment method using it |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111929460A (en) * | 2020-08-19 | 2020-11-13 | 河南科技大学 | Sampling, chip and liquid inlet control device suitable for microfluidic automatic detection |
| CN111929460B (en) * | 2020-08-19 | 2024-03-01 | 河南科技大学 | Sampling, chip and liquid inlet control device suitable for microfluidic automatic detection |
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| CN108980459B (en) | 2020-02-18 |
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