CN108969396A - A kind of gel skin care item and preparation method thereof containing NMN - Google Patents
A kind of gel skin care item and preparation method thereof containing NMN Download PDFInfo
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- CN108969396A CN108969396A CN201811172251.2A CN201811172251A CN108969396A CN 108969396 A CN108969396 A CN 108969396A CN 201811172251 A CN201811172251 A CN 201811172251A CN 108969396 A CN108969396 A CN 108969396A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of gel skin care item and preparation method thereof containing NMN, it is related to technical field of skin care, it is mostly ball-type or subsphaeroidal multilamellar vesicles structure that the obtained KGM modified phospholipid load transdermal alcohol plastid of NMN, which is the novel form of one kind, it is more stable with thermodynamics, partial size is smaller, and encapsulation rate is high, have percutaneous abilities faster, it is stronger, skin-tolerant can be good, the features such as dosage is less, reduces the incidence of adverse reaction, improves safety.And, the preparation process for preparing gel skin care item using the alcohol plastid is simple, NMN alcohol plastid can be obtained using stirring, homogeneous, ultrasound, filtering, alcohol plastid and penetrating agent are uniformly mixed the Ethosomal gel skin care item that can be obtained containing NMN with the gel-type vehicle being swollen again after mixing.
Description
Technical field
The present invention relates to technical field of skin care, a kind of gel skin care containing NMN that can be used for improving looks is referred in particular to
Product and preparation method thereof.
Background technique
In the prior art, alcohol plastid has hypotoxicity, hypoimmunity, good cell compatibility, can load water simultaneously
The advantages that dissolubility, fat-soluble macromolecular drug, thus received significant attention in drug delivery especially cutaneous penetration field.Alcohol
Plastid contains the ethyl alcohol of relatively high volume fraction, makes it have imitated vesicle structure, and form is mostly subsphaeroidal or spherical, shape circle
Whole smooth, the presence of ethyl alcohol improves lipophilicity and amphiphilic species in the phospholipid bilayer of vesica and the dissolution at aqueous center
Degree.Alcohol plastid carries drug first and penetrates cuticula arrival deep skin through intercellular pathways, then discharges drug, makes drug to skin
Skin deep layer is distributed and promotes percutaneous drug absorption.Its detailed process are as follows: 1. ethyl alcohol changes the close-packed arrays of lipid between horn cell,
Enhance its mobility, permeability enhancing；2. alcohol plastid is using its flexible and morphotropism, by between disorganized horn cell
Lipid carries drug and reaches deep skin；Enter in the cell of deep skin 3. alcohol plastid carries drug, plays locally targeting
Effect；4. the cell membrane fusion of alcohol plastid and deep skin, release drug, are distributed drug to deep skin, and promote its warp
Skin absorbs.Alcohol plastid may also promote drug to deep skin distribution and percutaneous absorbtion through hair follicle and sebaceous glands approach.Therefore, alcohol
Plastid film is flexible preferably, and when passing through skin barrier, deformability increases, and is more suitable for passing through horn cell gap, is to take
Carry the ideal carrier of macromolecular.
Currently, common transdermal drug delivery system, refers to and be administered in skin surface, drug is each through skin with certain speed
Layer, enters Whole Body blood circulation by capillary and reaches effective blood drug concentration, realizes whole body or local therapeutic effects
Novel form.Compared to administration modes such as oral, intravenous injections, cutaneous penetration has the first pass effect for avoiding liver and stomach and intestine, drop
The fluctuation of low blood concentration, avoid drug to the stimulation of gastrointestinal tract, administration hurtless measure, compliance is strong the advantages that, and directly from
Skin surface administration, to the effect in terms of skin care and beauty, becomes apparent.
NMN is the reduction-state of nicotinamide adenine dinucleotide, for the citric acid in glycolysis and cellular respiration
Circulation.There are in each living cells of human body, they react NMN with oxygen, generate energy, thousands of kinds of lifes intracorporal to people
Reason metabolic response all plays a crucial role.How much closely bound up with many diseases the content of NMN is in human body cell, as Ah
Wurz sea is write from memory disease, Parkinson, muscular atrophy etc..Scientist is the study found that cancer is because intracellular DNA is by carcinogen
Attack after, by damage without caused by time repairing.NMN can activate DNA repair enzyme (PARP), repair rapidly
The DNA of damage, prevents it from evolving into cancer.Moreover, NMN or superpower antioxidant can remove interior free yl, prevent cancer
The process of disease.We can supplement NMN by diet for body, but the amount absorbed is very low.NMN is highly unstable, easily
It degrades.And cannot be smoothly absorbed after oral NMN, because NMN has the characteristics that acid nonfast, to take in from outside NMN
When by human stomach, the influence that will receive gastric acid causes to lose activity, and absorptivity is generally relatively low, and most of ingredient arrives
It is just oxidized and degrades before up to blood, keep its application limited.NMN can be outer to being continuously replenished in body by skin action pathway
Source can be effectively prevented the generation with delay skin aging process.Show NMN with prolonged application not only according to clinical verification and have and is anti-
The effects of wrinkle, nti-freckle are dispelled outside the remarkable efficacies such as pigment, and there are also anti-inflammatory, sun-proof, health cares, anti-aging.But due to steady at normal temperature
Qualitative difference, biological half-life is short, is easily digested and had the shortcomings that immunogenicity, and limits its potential application.
Currently, there are many administration modes, such as oral, injection by NMN, but due to the property of drug itself, inevitably
Lead to this disadvantage of frequent drug administration.In order to improve the compliance of patient, while increasing the bioavilability of NMN, and remains constant
Effective blood drug concentration, exploitation can be spaced the long period administration NMN alcohol plastid have great meaning.
Summary of the invention
The technical problems to be solved by the present invention are: the administration problem of above-mentioned mentioned NMN.
In order to solve the above-mentioned technical problem, the invention discloses a kind of gel skin care item containing NMN, according to weight content
Meter, the composition of the gel skin care item are as follows:
In parts by weight, the composition of the alcohol plastid are as follows:
Further, the composition is in gel, and the gel-type vehicle is carbomer.
Further, the particle size range of vesica is 40-80nm in the alcohol plastid.
In addition, also disclosing the preparation method of the gel skin care item described in one kind containing NMN, include the following steps:
S1, gel-type vehicle is weighed, is sufficiently swollen with distilled water at room temperature；
S2, moisturizer, preservative, permeation enhancers are added thereto；
It is slowly added to pH adjusting agent under S3, stirring condition and adjusts it to neutrality；
S4, it is sufficiently mixed uniformly up to colorless and transparent Blank gel；
S5, Blank gel is mixed with alcohol plastid, is developed uniformly up to Ethosomal gel skin care item.
Further, the preparation of the alcohol plastid includes the following steps:
A, KGM, phosphatide, cholesterol, stabilizer, antioxidant is weighed to be added to the container；
B, low-molecular-weight alcohol is added, stirs and makes it completely dissolved；
C, NMN is added, after mixing, water is added and stirs；
D, homogeneous, ultrasonic treatment are carried out again, are filtered up to alcohol plastid filtrate.
Further, in the preparation of the alcohol plastid, low mass molecule alcohol be added is in dehydrated alcohol, isopropanol or propylene glycol
One or more, magnetic agitation, water-bath, whipping temp be 10-40 DEG C, make it completely dissolved.
Further, it in the preparation of the alcohol plastid, is added water to using injection method, in the forming of the alcohol plastid
The total weight 100% of water is meter, and the injection rate of the distilled water is that 2-10% is per minute.
Further, in the preparation of the alcohol plastid, whole grain, homogenizing time 10- are carried out using high speed dispersion homogenizer
20min, homogeneous speed are 1000-8000r/min.
Further, in the preparation of the alcohol plastid, the time of the ultrasonic treatment is 20-45min.
Further, in the preparation of the alcohol plastid, the filtering is carried out using 0.22 μm or 0.45 μm of filter membrane.
It is mostly ball-type or nearly ball that the KGM modified phospholipid load transdermal alcohol plastid of NMN that the present invention obtains, which is the novel form of one kind,
The multilamellar vesicles structure of shape has thermodynamics more stable, and partial size is smaller, and encapsulation rate is high, have percutaneous abilities faster, stronger, skin
The features such as skin tolerance performance is good, and dosage is less, reduces the incidence of adverse reaction, improves safety.And utilize the alcohol plastid
The preparation process for preparing gel skin care item is simple, NMN alcohol plastid can be obtained using stirring, homogeneous, ultrasound, filtering, by alcohol matter
Body and penetrating agent are uniformly mixed with the gel-type vehicle being swollen again after mixing can obtain the Ethosomal gel containing NMN
Skin care item.
Detailed description of the invention
Concrete scheme of the invention is described in detail with reference to the accompanying drawing
Fig. 1 is the TEM image of vesica in alcohol plastid；
Fig. 2 is the histogram of particle size distribution of vesica in alcohol plastid；
Fig. 3 is the grading curve figure of vesica in alcohol plastid；
Fig. 4 is the vitro cumulative release profiles of alcohol plastid transdermal experiment；
Fig. 5 is the dermal penetration rate release profiles of alcohol plastid.
Specific embodiment
To explain the technical content, the achieved purpose and the effect of the present invention in detail, below in conjunction with embodiment and cooperate attached
Figure is explained in detail.
Embodiment 1
The preparation of alcohol plastid:
The lecithin of precise, cholesterol, vitamin E, QKGM, 4%wtPEG-4000 solution are sequentially added into taper
In bottle, dehydrated alcohol is added into conical flask and carries out magnetic agitation, stirring in water bath temperature is 40 DEG C, is made it completely dissolved.Sufficiently
After dissolution, NMN is added thereto, after mixing, water is added using injection method and is distilled into the forming of the alcohol plastid
The total weight 100% of water is meter, and the injection rate of the distilled water is 10% per minute.Gained mixed solution is stirred into 30min,
Above-mentioned solution is subjected to high speed dispersion homogenizer and carries out whole grain, homogenizing time 10min, homogeneous speed is 8000r/min, will be equal
Solution after matter carries out ultrasound procedure, ultrasonic time 20min, finally with 0.22 μm of membrane filtration to get to alcohol plastid filtrate.
Embodiment 2
The preparation of alcohol plastid:
The lecithin of precise, cholesterol, vitamin E, QKGM are sequentially added in conical flask, are added into conical flask
Dehydrated alcohol carries out magnetic agitation, and whipping temp is 20 DEG C, makes it completely dissolved.After completely dissolution, NMN is added thereto, mixes
After closing uniformly, distilled water is added using injection method, is to count with the total weight 100% of the water in the forming of the alcohol plastid, institute
The injection rate for stating distilled water is 20% per minute.Gained mixed solution is stirred into 60min, above-mentioned solution is subjected to high speed dispersion
Homogenizer carries out whole grain, homogenizing time 20min, and homogeneous speed is 6000r/min, and the solution after homogeneous is carried out ultrasonic behaviour
Make, ultrasonic time 45min, finally with 0.45 μ membrane filtration to get to alcohol plastid filtrate.
Embodiment 3
The preparation of NMN Ethosomal gel skin care item
Weigh 1g carbomer gel matrix, be sufficiently swollen with 15g distilled water under room temperature, by 1.5:1 (triethanolamine:
Carbomer: w/w) pH adjusting agent triethanolamine is added dropwise, carbomer gel matrix is obtained after mixing evenly, and ethyl alcohol is added, and (ethyl alcohol contains
Measure identical as ethanol content in alcohol plastid) and moisturizer, preservative, permeation enhancers are added, three second are slowly added under stirring condition
Hydramine adjusts it to neutrality, is sufficiently mixed uniformly up to colorless and transparent Blank gel.By the weight such as NMN alcohol plastid and Blank gel
Part mixing is developed uniformly to get fine and smooth flaxen NMN Ethosomal gel skin care item.
Experimental example
1, images of transmissive electron microscope test is carried out to alcohol plastid, test results are shown in figure 1, and it will be seen from figure 1 that alcohol
Plastid is formed with the spherical vesica to differ in size.
2, alcohol plastid vesica partial size is tested, test result is as shown in Figure 2 and Figure 3, of the invention according to attached drawing
The average grain diameter of alcohol plastid vesica is 57.1nm, and most of vesica particle diameter distribution is within the scope of 40-80nm.
3, the transdermal test of rats in vitro is carried out, vitro cumulative release profiles as shown in Figure 4 are obtained, and adds up within 24 hours to release
It is unconventional and unrestrained to 30%.And dermal penetration rate release profiles as shown in Figure 5, meet transdermal kinetic theory, osmotic engine
Learning equation is Q=59.34t-20.91 wherein steady-state permeation rate Js=59.34 μ gxh-1·cm-2.By to rats in vitro
It is transdermal research shows that prepared NMN Ethosomal gel preparation of the invention has certain controlled-release function, NMN is in homeostasis for 24 hours
Percutaneous rate is 1301.15 μ g/cm2, accumulation transmitance is 27.3%.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent process transformation made by bright specification and accompanying drawing content is applied directly or indirectly in other relevant technical fields,
Similarly it is included within the scope of the present invention.
Claims (10)
1. a kind of gel skin care item containing NMN, which is characterized in that according to weight content meter, the composition of the gel skin care item are as follows:
In parts by weight, the composition of the alcohol plastid are as follows:
2. the gel skin care item containing NMN as described in claim 1, it is characterised in that: the composition is in gel, described solidifying
Gel matrix is carbomer.
3. the gel skin care item containing NMN as described in claim 1, it is characterised in that: the partial size model of vesica in the alcohol plastid
It encloses for 40-80nm.
4. a kind of preparation method of the gel skin care item as described in claim any one of 1-3 containing NMN, which is characterized in that including
Following steps:
S1, gel-type vehicle is weighed, is sufficiently swollen with distilled water at room temperature；
S2, moisturizer, preservative, permeation enhancers are added thereto；
It is slowly added to pH adjusting agent under S3, stirring condition and adjusts it to neutrality；
S4, it is sufficiently mixed uniformly up to colorless and transparent Blank gel；
S5, Blank gel is mixed with alcohol plastid, is developed uniformly up to the Ethosomal gel skin care item containing NMN.
5. the preparation method of the gel skin care item containing NMN as claimed in claim 4, which is characterized in that the preparation of the alcohol plastid
Include the following steps:
A, KGM, phosphatide, cholesterol, stabilizer, antioxidant is weighed to be added to the container；
B, low-molecular-weight alcohol is added, stirs and makes it completely dissolved；
C, NMN is added, after mixing, water is added and stirs；
D, homogeneous, ultrasonic treatment are carried out again, are filtered up to alcohol plastid filtrate.
6. the preparation method of the gel skin care item containing NMN as claimed in claim 5, it is characterised in that: the preparation of the alcohol plastid
In, low mass molecule alcohol be added is one or more of dehydrated alcohol, isopropanol or propylene glycol, magnetic agitation, water-bath, stirring temperature
Degree is 10-40 DEG C, is made it completely dissolved.
7. the preparation method of the gel skin care item containing NMN as claimed in claim 5, it is characterised in that: the preparation of the alcohol plastid
In, it is added water to using injection method, is to count with the total weight 100% of the water in the forming of the alcohol plastid, the distilled water
Injection rate is that 2-10% is per minute.
8. the preparation method of the gel skin care item containing NMN as claimed in claim 5, it is characterised in that: the preparation of the alcohol plastid
In, whole grain, homogenizing time 10-20min are carried out using high speed dispersion homogenizer, homogeneous speed is 1000-8000r/min.
9. the preparation method of the gel skin care item containing NMN as claimed in claim 5, it is characterised in that: the preparation of the alcohol plastid
In, the time of the ultrasonic treatment is 20-45min.
10. the preparation method of the gel skin care item containing NMN as claimed in claim 5, it is characterised in that: the preparation of the alcohol plastid
In, the filtering is carried out using 0.22 μm or 0.45 μm of filter membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811172251.2A CN108969396A (en) | 2018-10-09 | 2018-10-09 | A kind of gel skin care item and preparation method thereof containing NMN |
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| CN201811172251.2A CN108969396A (en) | 2018-10-09 | 2018-10-09 | A kind of gel skin care item and preparation method thereof containing NMN |
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| CN108969396A true CN108969396A (en) | 2018-12-11 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638827A (en) * | 2019-10-17 | 2020-01-03 | 泓博元生命科技（深圳）有限公司 | Application of NADH and its salt in preparing skin pigment inhibitor |
| CN112891241A (en) * | 2021-02-06 | 2021-06-04 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
Citations (3)
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| CN102552147A (en) * | 2011-02-11 | 2012-07-11 | 舒泰神（北京）生物制药股份有限公司 | Bullatacin ethosome gel and preparation method thereof |
| CN102579323A (en) * | 2011-02-21 | 2012-07-18 | 舒泰神（北京）生物制药股份有限公司 | Paclitaxel ethosome gel and preparation method thereof |
| CN106011163A (en) * | 2016-05-19 | 2016-10-12 | 武汉华美生物工程有限公司 | Method for cell-free expression of signal protein and expression system |
-
2018
- 2018-10-09 CN CN201811172251.2A patent/CN108969396A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552147A (en) * | 2011-02-11 | 2012-07-11 | 舒泰神（北京）生物制药股份有限公司 | Bullatacin ethosome gel and preparation method thereof |
| CN102579323A (en) * | 2011-02-21 | 2012-07-18 | 舒泰神（北京）生物制药股份有限公司 | Paclitaxel ethosome gel and preparation method thereof |
| CN106011163A (en) * | 2016-05-19 | 2016-10-12 | 武汉华美生物工程有限公司 | Method for cell-free expression of signal protein and expression system |
Non-Patent Citations (1)
| Title |
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| 赵娟等: ""烟酰胺单核苷酸的研究及应用进展"", 《食品科技》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638827A (en) * | 2019-10-17 | 2020-01-03 | 泓博元生命科技（深圳）有限公司 | Application of NADH and its salt in preparing skin pigment inhibitor |
| CN112891241A (en) * | 2021-02-06 | 2021-06-04 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
| CN112891241B (en) * | 2021-02-06 | 2022-06-10 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
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