CN1089485A - Compound henbane seed " Tongweiling " tablet and preparation method thereof - Google Patents
Compound henbane seed " Tongweiling " tablet and preparation method thereof Download PDFInfo
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- CN1089485A CN1089485A CN 93107253 CN93107253A CN1089485A CN 1089485 A CN1089485 A CN 1089485A CN 93107253 CN93107253 CN 93107253 CN 93107253 A CN93107253 A CN 93107253A CN 1089485 A CN1089485 A CN 1089485A
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Abstract
A kind of compound henbane seed " Tongweiling " tablet and preparation method thereof.Described Tongweiling tablet is made of the scopolamine hydrobromide that extracts in the Chinese medicine Semen Hyoscyami, hydrochloric acid mountain gelsemium henbane alkali and Calculus Bovis, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Scolopendra and Scorpio, and it is oral to make tablet.Be used with compound henbane seed injection to artery or vein, the effective percentage of treatment epileptics is up to 83.6%.
Description
The present invention relates to a kind of Chinese patent medicine Tongweiling tablet for the treatment of epileptics and preparation method thereof.
The effect of Tongweiling tablet is to remove cerebral microcirculation disturbance, activating blood circulation to dissipate blood stasis, and anti-acetylcholine is also regulated autonomic nervous dysfunction, thereby can reach the purpose of treatment epileptics.The computer international online retrieval shows do not have to find that with Semen Hyoscyami be the Chinese formulated products of main effective ingredient as the treatment epileptics.
The objective of the invention is to develop a kind of compound henbane seed " Tongweiling " tablet that is used the treatment epileptics with compound recipe Semen Hyoscyami artery and vein injection and preparation method thereof.
(with the cubage in per 100,000) composed as follows of Tongweiling tablet:
Hyoscine hydrobromide 10-30g
Hydrochloric acid anisodamine 1000-1800g
Calculus Bovis 400-700g
Cornu Cervi Pantotrichum 580-720g
Rhizoma Gastrodiae 1500-2500g
Scorpio 2000-4000 bar
Scolopendra 2000-4000 bar
Adjuvant 1500-2000g
Hyoscine hydrobromide and hydrochloric acid anisodamine are the effective ingredient that extracts from the Chinese medicine Semen Hyoscyami, can buy from Hangzhou people's livelihood pharmaceutical factory and Beijing Pharmaceutical Factory No.3 at present.
Calculus Bovis, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Scolopendra and Scorpio all are general Chinese medicine, all can buy from pharmacy.Described adjuvant is starch and dextrin.
The preparation method of Tongweiling tablet is as follows:
1. with Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Scolopendra or below Scorpio pulverize separately to 200 order;
2. with commercially available medical stirrer,, said components and adjuvant be mixed in proportion stir by the requirement of galenic pharmacy method;
In above-mentioned blender while stirring adding distil water to make it moistening agglomerating to holding, the vibration degree of promptly scattering a little;
4. in baking oven, dry;
5. dried block is made granularity and is the granule about 2mm in medical pelletize;
6. the magnesium stearate of adding 1 ‰ makes the tablet of making smooth in above-mentioned granule;
7. with medical pelleter film-making;
8. random inspection is up to the standards.
It is qualified that described compound henbane seed " Tongweiling " tablet requires index to make a random inspection according to the Chinese Pharmacopoeia ordinary preparation.
In Pinglu County, Shanxi Province epileptics branch of institute of traditional Chinese medicine with Tongweiling tablet of the present invention and compound recipe Semen Hyoscyami artery and vein injection fit applications in clinical, the clinical sight of example time is looked into surplus 10,000, total effective rate to epileptics is 83.6%, and adopt tradition to treat the enamel total effective rate only is 34.8%, and medicine of the present invention is used for the treatment of epileptics and improves 38.8% than traditional remedies.
Described compound recipe Semen Hyoscyami artery and vein injection will have detailed description in same applicant's on the same day patent application.
Now introduce two typical cases.
Section certain, the man, 12 years old, because of when birth difficult labour, suffocate, the birth back promptly began to twitch on the 3rd day, show effect 7-9 every day, not sociable, can not stand, dementia be can't take care of oneself., left hospital 6 years after two courses of treatment at the oral Tongweiling tablet of the present invention of my institute and compound henbane seed injection to artery or vein injection for curing in 1986, epilepsy is controlled, and life can be taken care of oneself, the reading of having gone to school.
Thunder, the woman, 16 years old, to carry by the people and to have gone into a coma when coming hospitalize month surplusly, gatism be can't take care of oneself at all, the epileptics hundreds of that can show effect at most every day.Epileptics is promptly controlled one day after through above-mentioned two kinds of medicine partner treatments, can walk in the 6th day followingly, can freely run in the 12nd day.
Claims (2)
1, a kind of compound henbane seed " Tongweiling " tablet is characterized in that it constitutes (with the cubage in per 100,000) by following component:
Hyoscine hydrobromide 10-30g
Hydrochloric acid anisodamine 1000-1800g
Calculus Bovis 400-700g
Cornu Cervi Pantotrichum 580-720g
Rhizoma Gastrodiae 1500-2500g
Scorpio 2000-4000 bar
Scolopendra 2000-4000 bar
Adjuvant 1500-2000g
2, the manufacture method of Tongweiling tablet according to claim 1 is characterized in that preparation method is as follows:
With Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Scolopendra, below Scorpio pulverize separately to 200 order;
2. with commercially available medical stirrer,, said components and adjuvant be mixed in proportion stir by the requirement of galenic pharmacy method;
3. adding distilled water in above-mentioned blender while stirring, to make it moistening agglomerating to holding, a little the vibration degree of promptly scattering;
4. in baking oven, dry;
5. dried block is made granularity and is the granule about 2mm in medical comminutor;
6. in above-mentioned granule, add 1 ‰ magnesium stearate smoothing preparation;
7. with medical pelleter film-making;
8. random inspection is up to the standards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107253 CN1089485A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed " Tongweiling " tablet and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100036.X | 1993-01-03 | ||
| CN93100036 | 1993-01-03 | ||
| CN 93107253 CN1089485A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed " Tongweiling " tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089485A true CN1089485A (en) | 1994-07-20 |
Family
ID=25742972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93107253 Pending CN1089485A (en) | 1993-01-03 | 1993-06-17 | Compound henbane seed " Tongweiling " tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1089485A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043745A1 (en) * | 1999-12-17 | 2001-06-21 | Fundação De Amparo Á Pesquisa Do Estado De São Paulo - Fapesp | The use of scopolamine salts |
| WO2006116804A1 (en) * | 2005-04-29 | 2006-11-09 | Asia Pacific Life Sciences Pte Ltd | Processed hyoscyamus seed agent for the treatment of tissue disruption |
| KR100736505B1 (en) | 1999-12-17 | 2007-07-06 | 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 | The use of scopolamine salts |
-
1993
- 1993-06-17 CN CN 93107253 patent/CN1089485A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043745A1 (en) * | 1999-12-17 | 2001-06-21 | Fundação De Amparo Á Pesquisa Do Estado De São Paulo - Fapesp | The use of scopolamine salts |
| JP2003530315A (en) * | 1999-12-17 | 2003-10-14 | フンダソン・デ・アンパロ・アペスキーザ・ド・エスタード・デ・サンパウロ（Ｆａｐｅｓｐ） | Use of scopolamine salt |
| KR100736505B1 (en) | 1999-12-17 | 2007-07-06 | 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 | The use of scopolamine salts |
| WO2006116804A1 (en) * | 2005-04-29 | 2006-11-09 | Asia Pacific Life Sciences Pte Ltd | Processed hyoscyamus seed agent for the treatment of tissue disruption |
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