CN108939175A - Colchicin coating FirebirdTM and preparation method thereof - Google Patents
Colchicin coating FirebirdTM and preparation method thereof Download PDFInfo
- Publication number
- CN108939175A CN108939175A CN201811246733.8A CN201811246733A CN108939175A CN 108939175 A CN108939175 A CN 108939175A CN 201811246733 A CN201811246733 A CN 201811246733A CN 108939175 A CN108939175 A CN 108939175A
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- Prior art keywords
- colchicin
- bracket
- coating
- polymer
- firebirdtm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Abstract
The present invention provides a kind of colchicin coating FirebirdTM and preparation method thereof, a kind of colchicin coating FirebirdTM, it is characterized by comprising bracket, coated in the polymer coating on bracket and the colchicin being supported in polymer coating, wherein, colchicin in coating is coated in polymer coating in the form of microballoon.Colchicin coating bracket of the present invention has good biocompatibility, and colchicin discharges uniform, controllable, can obviously inhibit the inflammatory reaction of stenter to implant part, prevent vascular smooth muscle cells hyper-proliferative and in-stent restenosis, is suitble to clinical application.
Description
Technical field
The present invention relates to a kind of colchicin coating FirebirdTMs, prepare the invention further relates to a kind of with autumn waters -- limid eyes alkali coating
FirebirdTM method, belong to medical instruments field.
Background technique
One of major complications after percutaneous transluminal coronary stent implantation are in-stent restenosis at present.After stenting injury of blood vessel and
Local inflammation reaction causes the proliferation and migration of vascular smooth muscle cells, so as to cause vascellum endometrial hyperplasia and restenosis.At present
Most of selection of drug is based on inhibiting vascular smooth muscle cell proliferation and migrate, such as taxol and rapamycin, however
These drugs are without anti-inflammatory effect, the inflammatory reaction that can not be effectively improved at injury of blood vessel.
Summary of the invention
The purpose of the present invention is to provide a kind of colchicin coating FirebirdTMs and preparation method thereof, to solve above-mentioned ask
Topic.
Present invention employs following technical solutions:
A kind of colchicin coating FirebirdTM, it is characterised in that:
Including bracket, coated in the polymer coating on bracket and the colchicin being supported in polymer coating,
Wherein, the colchicin in coating is coated in polymer coating in the form of microballoon.
Further, colchicin bracket for eluting medicament of the invention also has a feature in that the partial size of microballoon is
0.01-50 microns.
Further, colchicin bracket for eluting medicament of the invention also has a feature in that the drug colchicin
Weight ratio with polymer is 0.5-2.
Further, colchicin bracket for eluting medicament of the invention also has a feature in that every square millimeter of bracket table
Face medicament contg is 0.1-20 microgram.
Further, colchicin bracket for eluting medicament of the invention also has a feature in that wherein, the bracket
Substrate includes stainless steel, cobalt alloy, magnesium alloy and the good metal of other biological compatibility and alloy.
Further, it is degradable also to have a feature in that polymer is selected from for colchicin bracket for eluting medicament of the invention
Polymer.
Further, colchicin bracket for eluting medicament of the invention, also has a feature in that the degradable polymer
Selected from cellulose, glycan, chitin, chitosan or derivatives thereof, poly- hydroxy alkyl alcohol ester, poly- β malate, poly- Alpha-hydroxy
Esters of gallic acid, polycaprolactone, polybutylcyanoacrylate, polyaminoacid, false polyaminoacid, polymeric polyglycolide-polylactide copolymer, gather cream
Any one in acid, polycarbonate, polyanhydride, polyvinylpyrrolidone or polyvinylpyrrolidone or two kinds and two kinds
Above mixture.
Further, colchicin bracket for eluting medicament of the invention also has a feature in that bracket for balloon expandable hat
Shape arterial bracket, cerebrovascular stent or peripheral vascular stents.
The present invention also provides a kind of methods for preparing the FirebirdTM with autumn waters -- limid eyes alkali coating:
(1) organic solvent is dissolved the polymer in, colchicin is dissolved in chloroform or acetone, and it is living to be separately added into surface
Property agent, by two solution mix, emulsification, obtain lotion, then by this Emulsion Spraying on bracket, after solvent flashing obtain drug apply
Layer, the partial size for being formed by colchicin particle is 0.01-50 microns；
(2) liquid solvent or gas-solvent are then used, levelling emulsion particle surface polymer is dried in vacuo, at this time the autumn
Tazettine is fixed in polymer coating with microspheres form, i.e. acquisition colchicin bracket for eluting medicament.Further, of the invention
Preparation have autumn waters -- limid eyes alkali coating FirebirdTM method, also have a feature in that colchicin and polymer coating
Weight ratio is 0.5-2.
Advantageous effect of the invention
Colchicin coating bracket of the present invention has good biocompatibility, and colchicin discharges uniform, controllable, can be bright
The aobvious inflammatory reaction for inhibiting stenter to implant part, prevents vascular smooth muscle cells hyper-proliferative and in-stent restenosis, is suitble to face
Bed application.
Specific embodiment
Illustrate technical solution of the present invention below in conjunction with specific embodiment.
<embodiment one>
The colchicin bracket for eluting medicament of present embodiment, including bracket, coated on bracket polymer coating and
The colchicin being supported on polymer coating.
Colchicin is wrapped in polymer microballoon, to achieve the purpose that drug substance stable is sustained.
The partial size for having wrapped up the polymer microballoon of colchicin particle is 0.01-2 microns.
The weight ratio of colchicin and polymer coating is 0.5.
Every square millimeter of rack surface medicament contg is 0.1 microgram.
The substrate of bracket includes stainless steel, cobalt alloy, magnesium alloy and the good material of other biological compatibility.
Polymer is selected from degradable polymer.
Degradable polymer be selected from cellulose, glycan, chitin, chitosan or derivatives thereof, poly- hydroxy alkyl alcohol ester,
Poly- β malate, poly- 'alpha '-hydroxy acids esters, polycaprolactone, polybutylcyanoacrylate, polyaminoacid, false polyaminoacid, poly- second
Lactide-lactide copolymer.One in polylactic acid, polycarbonate, polyanhydride, polyvinylpyrrolidone or polyvinylpyrrolidone
Kind or more or its copolymer.
Bracket of the present invention is the conventional intravascular stent for implantation, such as balloon expandable coronary stent, cerebrovascular branch
Frame, peripheral vascular stents etc..
Step:
(1) organic solvent is dissolved the polymer in, colchicin is dissolved in chloroform or acetone, and it is living to be separately added into surface
Property agent, by two solution mix, emulsification, obtain lotion, then by this Emulsion Spraying on bracket, after solvent flashing obtain drug apply
Layer controls mixing condition, so that the partial size for being formed by colchicin particle is 0.01-2 microns.
In lotion, the weight ratio of colchicin and polymer is 0.5.
Organic solvent is selected from the organic solvents such as tetrahydrofuran, methylene chloride, chloroform, dimethylformamide or DMSO
In.
In colchicin aqueous solution, the weight content of colchicin is 0.01% to saturated concentration.
Surfactant is selected from Span series or one or more of Tween series, Span series preferably Span 60 or
Span 80 etc., Tween series preferably Tween 60 or Tween 80, are added the 0.01-2% that weight is degradable polymer.
(2) liquid solvent or gas-solvent are then used, levelling emulsion particle surface polymer is dried in vacuo, at this time the autumn
Tazettine is fixed in polymer coating with microspheres form, i.e. acquisition colchicin bracket for eluting medicament.
<embodiment two>
The colchicin bracket for eluting medicament of present embodiment, including bracket, coated on bracket polymer coating and
The colchicin being supported on polymer coating.
Colchicin is wrapped in polymer microballoon, to achieve the purpose that drug substance stable is sustained.
The partial size for having wrapped up the polymer microballoon of colchicin particle is 2-10 microns.
The weight ratio of colchicin and polymer coating is 1.25.
Every square millimeter of rack surface medicament contg is 10 micrograms.
The substrate of bracket includes stainless steel, cobalt alloy, magnesium alloy and the good material of other biological compatibility；
Polymer is selected from degradable polymer.
Degradable polymer be selected from cellulose, glycan, chitin, chitosan or derivatives thereof, poly- hydroxy alkyl alcohol ester,
Poly- β malate, poly- 'alpha '-hydroxy acids esters, polycaprolactone, polybutylcyanoacrylate, polyaminoacid, false polyaminoacid, poly- second
Lactide-lactide copolymer.One in polylactic acid, polycarbonate, polyanhydride, polyvinylpyrrolidone or polyvinylpyrrolidone
Kind or more or its copolymer.
Bracket of the present invention is the conventional intravascular stent for implantation, such as balloon expandable coronary stent, cerebrovascular branch
Frame, peripheral vascular stents etc..
Step:
(1) organic solvent is dissolved the polymer in, colchicin is dissolved in chloroform or acetone, and it is living to be separately added into surface
Property agent, by two solution mix, emulsification, obtain lotion, then by this Emulsion Spraying on bracket, after solvent flashing obtain drug apply
Layer, the partial size for being formed by colchicin particle is 2-10 microns.
In lotion, the weight ratio of colchicin and polymer is 1.25.
Organic solvent is selected from the organic solvents such as tetrahydrofuran, methylene chloride, chloroform, dimethylformamide or DMSO
In.
In colchicin aqueous solution, the weight content of colchicin is 0.01% to saturated concentration.
Surfactant is selected from Span series or one or more of Tween series, Span series preferably Span 60 or
Span 80 etc., Tween series preferably Tween 60 or Tween 80, are added 1% that weight is degradable polymer.
(2) liquid solvent or gas-solvent are then used, levelling emulsion particle surface polymer is dried in vacuo, at this time the autumn
Tazettine is fixed in polymer coating with microspheres form, i.e. acquisition colchicin bracket for eluting medicament.
<embodiment three>
The colchicin bracket for eluting medicament of present embodiment, including bracket, coated on bracket polymer coating and
The colchicin being supported on polymer coating.
Colchicin is wrapped in polymer microballoon, to achieve the purpose that drug substance stable is sustained.
The partial size for having wrapped up the polymer microballoon of colchicin particle is 10-50 microns.
The weight ratio of colchicin and polymer coating is 2.
Every square millimeter of rack surface medicament contg is 20 micrograms.
The substrate of bracket includes stainless steel, cobalt alloy, magnesium alloy and the good material of other biological compatibility；
Polymer is selected from degradable polymer.
Degradable polymer be selected from cellulose, glycan, chitin, chitosan or derivatives thereof, poly- hydroxy alkyl alcohol ester,
Poly- β malate, poly- 'alpha '-hydroxy acids esters, polycaprolactone, polybutylcyanoacrylate, polyaminoacid, false polyaminoacid, poly- second
Lactide-lactide copolymer.One in polylactic acid, polycarbonate, polyanhydride, polyvinylpyrrolidone or polyvinylpyrrolidone
Kind or more or its copolymer.
Bracket of the present invention is the conventional intravascular stent for implantation, such as balloon expandable coronary stent, cerebrovascular branch
Frame, peripheral vascular stents etc..
Step:
(1) organic solvent is dissolved the polymer in, colchicin is dissolved in chloroform or acetone, and it is living to be separately added into surface
Property agent, by two solution mix, emulsification, obtain lotion, then by this Emulsion Spraying on bracket, after solvent flashing obtain drug apply
Layer, the partial size for being formed by colchicin particle is 10-50 microns.
In lotion, the weight ratio of colchicin and polymer is 2.
Organic solvent is selected from the organic solvents such as tetrahydrofuran, methylene chloride, chloroform, dimethylformamide or DMSO
In.
In colchicin aqueous solution, the weight content of colchicin is saturated concentration.
Surfactant is selected from Span series or one or more of Tween series, Span series preferably Span 60 or
Span 80 etc., Tween series preferably Tween 60 or Tween 80, are added 2% that weight is degradable polymer.
(2) liquid solvent or gas-solvent are then used, levelling emulsion particle surface polymer is dried in vacuo, at this time the autumn
Tazettine is fixed in polymer coating with microspheres form, i.e. acquisition colchicin bracket for eluting medicament.
Zoopery is carried out to the colchicin coating bracket of above-mentioned different pharmaceutical concentration:
Healthy miniature pig is divided into 5 groups: stainless steel bare mental stents group, blank control coating bracket group, 3 kinds of various concentrations
Colchicin coating bracket group, every group each 10.It will be dropped before the random implantation experiment pig coronary branches of bracket on DSA operating table
The vessel segment of branch (LAD) and right hat (RCA) suitable diameter.Experiment pig is put to death after 30 days, is taken out stenter to implant section blood vessel and is assessed blood
Tube wall inflammation and inner film thickness.As a result as follows:
Colchicin coating bracket section vascular wall is without necrosis, aneurysm and thrombosis, this prompt colchicum after (1) 30 day
Alkali bracket has good histocompatbility.
Colchicin coating bracket section blood vessel is compared with stainless steel bare mental stents and blank coating bracket section blood vessel after (2) 30 days
Inflammation significantly reduces, as shown in table 1.This prompt colchicin coating bracket has significant anti-inflammatory power.
Colchicin coating bracket section blood vessel is compared with stainless steel bare mental stents and blank coating bracket section blood vessel after (3) 30 days
Inner film thickness significantly reduces, and lumen significantly increases, as shown in table 2.This prompt colchicin coating bracket has significant anti-increasing
Ability is grown, in-stent restenosis is prevented.
Table 1: bracket anti-inflammatory power of the invention
Compared with bare metal stent and blank coating bracket group,*P < 0.05
Table 2: bracket anti-proliferative capacity of the invention
Compared with bare metal stent and blank coating bracket group,*P < 0.05.
Claims (10)
1. a kind of colchicin coating FirebirdTM, it is characterised in that:
Including bracket, coated in the polymer coating on bracket and the colchicin being supported in polymer coating,
Wherein, the colchicin in coating is coated in polymer coating in the form of microballoon.
2. colchicin bracket for eluting medicament according to claim 1, it is characterised in that:
The partial size of the microballoon is 0.01-50 microns.
3. colchicin coating bracket for controlling releasing and elution according to claim 1, it is characterised in that:
The weight ratio of the drug colchicin and polymer is 0.5-2.
4. colchicin bracket for controlling releasing and elution according to claim 1, it is characterised in that:
Every square millimeter of rack surface medicament contg is 0.1-20 microgram.
5. colchicin bracket for eluting medicament according to claim 1, which is characterized in that wherein, the substrate of the bracket
Including stainless steel, cobalt alloy, magnesium alloy and the good metal of other biological compatibility and alloy.
6. colchicin bracket for eluting medicament according to claim 1, it is characterised in that: polymer is selected from degradable polymerization
Object.
7. colchicin bracket for eluting medicament according to claim 6, it is characterised in that:
The degradable polymer be selected from cellulose, glycan, chitin, chitosan or derivatives thereof, poly- hydroxy alkyl alcohol ester,
Poly- β malate, poly- 'alpha '-hydroxy acids esters, polycaprolactone, polybutylcyanoacrylate, polyaminoacid, false polyaminoacid, poly- second
Lactide-lactide copolymer, appointing in polylactic acid, polycarbonate, polyanhydride, polyvinylpyrrolidone or polyvinylpyrrolidone
One kind of anticipating or two kinds and two or more mixtures.
8. colchicin bracket for eluting medicament according to claim 1, which is characterized in that
Bracket is balloon expandable coronary stent, cerebrovascular stent or peripheral vascular stents.
9. a kind of method for preparing the FirebirdTM with autumn waters -- limid eyes alkali coating:
(1) organic solvent is dissolved the polymer in, colchicin is dissolved in chloroform or acetone, and be separately added into surface-active
Two solution are mixed, emulsification, obtain lotion by agent, are obtained drug then by this Emulsion Spraying on bracket, after solvent flashing and are applied
Layer, the partial size for being formed by colchicin particle is 0.01-50 microns；
(2) liquid solvent or gas-solvent are then used, levelling emulsion particle surface polymer is dried in vacuo, at this time colchicum
Alkali is fixed in polymer coating with microspheres form, i.e. acquisition colchicin bracket for eluting medicament.
10. the method that preparation as claimed in claim 9 has the FirebirdTM of autumn waters -- limid eyes alkali coating, it is characterised in that:
The weight ratio of the colchicin and polymer coating is 0.5-2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811246733.8A CN108939175A (en) | 2018-10-24 | 2018-10-24 | Colchicin coating FirebirdTM and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811246733.8A CN108939175A (en) | 2018-10-24 | 2018-10-24 | Colchicin coating FirebirdTM and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108939175A true CN108939175A (en) | 2018-12-07 |
Family
ID=64481038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811246733.8A Pending CN108939175A (en) | 2018-10-24 | 2018-10-24 | Colchicin coating FirebirdTM and preparation method thereof |
Country Status (1)
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| CN (1) | CN108939175A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977995A (en) * | 2005-12-08 | 2007-06-13 | 上海康德莱企业发展集团有限公司 | Method for preparing coated vascular stent |
| CN101161300A (en) * | 2007-11-27 | 2008-04-16 | 北京美中双和医疗器械有限公司 | Arsenic trioxide medicament elution bracket |
| CN101171042A (en) * | 2005-05-05 | 2008-04-30 | 汉莫堤克股份有限公司 | A method for coating the whole surface of a built-in prothesis |
| US8728510B1 (en) * | 2002-03-15 | 2014-05-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing a bioadhesive material |
| US20170007745A1 (en) * | 2004-12-07 | 2017-01-12 | Surmodics, Inc. | Coatings with crystallized active agent(s) and methods |
-
2018
- 2018-10-24 CN CN201811246733.8A patent/CN108939175A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8728510B1 (en) * | 2002-03-15 | 2014-05-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing a bioadhesive material |
| US20170007745A1 (en) * | 2004-12-07 | 2017-01-12 | Surmodics, Inc. | Coatings with crystallized active agent(s) and methods |
| CN101171042A (en) * | 2005-05-05 | 2008-04-30 | 汉莫堤克股份有限公司 | A method for coating the whole surface of a built-in prothesis |
| CN1977995A (en) * | 2005-12-08 | 2007-06-13 | 上海康德莱企业发展集团有限公司 | Method for preparing coated vascular stent |
| CN101161300A (en) * | 2007-11-27 | 2008-04-16 | 北京美中双和医疗器械有限公司 | Arsenic trioxide medicament elution bracket |
Non-Patent Citations (1)
| Title |
|---|
| 郭华 等: ""秋水仙碱对大鼠主动脉炎症因子的影响"", 《医学研究生学报》 * |
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Application publication date: 20181207 |