CN108939077A - It is a kind of to treat neck-shoulder pain, lumbago and leg pain and have complexing agent and its preparation method that strengthening tendons are good for network function - Google Patents

It is a kind of to treat neck-shoulder pain, lumbago and leg pain and have complexing agent and its preparation method that strengthening tendons are good for network function Download PDF

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Publication number
CN108939077A
CN108939077A CN201810853763.9A CN201810853763A CN108939077A CN 108939077 A CN108939077 A CN 108939077A CN 201810853763 A CN201810853763 A CN 201810853763A CN 108939077 A CN108939077 A CN 108939077A
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Prior art keywords
pain
acid
molecular weight
extract
specifically
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CN201810853763.9A
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赵永亮
王卫国
王冠轶
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Zhengzhou Bio Engineering Co Ltd
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Zhengzhou Bio Engineering Co Ltd
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Priority to CN201810853763.9A priority Critical patent/CN108939077A/en
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Abstract

The invention belongs to pain science and biological medicine health care product science and technology field, and in particular to a kind of to treat neck-shoulder pain, lumbago and leg pain and have complexing agent and its preparation method that strengthening tendons are good for network function.The complexing agent be slowed down by pain biology agent, promoting blood circulation and removing obstruction in channels dose, joint biological lubricants, tendon muscle strengthener, cell physiological function conditioner and cell normal growth be metabolized required agent using low-temperature environment-friendly technique it is refined it is a kind of have it is promoting blood circulation and removing obstruction in channels, dispelling wind and eliminating dampness, cold extermination toxin expelling, relaxing muscles and tendons is good for network, strengthening the muscles and bones, putrefaction-removing granulation-promoting, anti-inflammatory health care nourish multicomponent targeting preparation that is neural and muscle function safe and efficient and having no toxic side effect；Neck-shoulder pain, lumbago and leg pain caused by many reasons can not only be treated, rehabilitation physical efficiency can be also improved；This product is easy to use, good effect, quick.Existing drug effect, and have the safety of health food and cosmetics, it can be not only used for pain patients, but also as the daily health caring articles of ordinary people.

Description

It is a kind of to treat neck-shoulder pain, lumbago and leg pain and have complexing agent and its preparation method that strengthening tendons are good for network function
Technical field
The invention belongs to pain science and biological medicine health care product science and technology field, and in particular to a kind of to treat neck shoulder waist Skelagia simultaneously has complexing agent and its preparation method that strengthening tendons are good for network function.
Background technique
With the acceleration of people's life rhythm, the increase of work and life pressure, in addition environmental pollution and food problems, people Health problem it is more and more.Neck-shoulder pain, lumbago and leg pain has become a kind of common disease and frequently-occurring disease.Especially, with people's age Increase the arrival with aging society, the reduction of body physiological and neuromuscular function and metabolic capability, neck-shoulder pain, lumbago and leg pain or difficulty It is aching and tired with the unknown chronic ache described or stiff equal malaise symptoms have fed through to nearly all the elderly.Due to information-based and The arrival of network times, many people young men are also tired by neck-shoulder pain, lumbago and leg pain and " mouse hand ".
Neck-shoulder pain, lumbago and leg pain is because of chronic strain or caused by moving undue force or suffer from cold cold-dampness and aseptic inflammation mostly A major class common disease and frequently-occurring disease based on patient part pain, swelling even function limitation, comprising: cervical spondylosis, scapulohumeral periarthritis, Tenosynovitis, prolapse of lumbar intervertebral disc, lumbar muscle strain, osteoproliferation etc. know because or do not know that, because of disease, common manifestation is without cuticular breakdown Acute and chronic neck pain, pain in my shoulder, arm pain, wrist pain, pain in the loins, skelagia, arthralgia, courbature, neuralgia or body muscle it is sour The malaise symptoms such as tired or stiff.In general neck-shoulder pain, lumbago and leg pain is broadly divided into following 3 class: (one) acute injury of soft tissue: soft group Knit the unexpected attack, gravity compressing and drawing, the torsion more than soft tissue physiological range and the damage generated by external force. (2) soft tissue chronic injury: the reasons such as living habit or occupational position cause, such as: for a long time bow bend over the desk, sitting, long-time It bends over and sleeping posture is improper or using high pillow etc., so that Portions of soft tissue is in drawing state for a long time, be pulled in tissue Blood vessel is chronically at half unobstructed and cause histocyte anoxic, so that the permeability of blood vessel is changed, haemocyte exudation, tissue become Property, interfibrillar substance increase, soft tissue occur lesion so as to cause neck, shoulder, waist and leg pain symptom.(3) the wet pain of injury of chill: chill is wet can Body is reduced to the tolerance of pain, makes that muscle cramp, thin vessels are shunk, lymphatic return slows down, soft tissue blood circulation occurs Obstacle generates aseptic inflammation, to generate neck-shoulder pain, lumbago and leg pain.The positions such as muscle bone, joint, muscle can all ache when morbidity Bitterly, swelling, numbness, tetanic, serious person can cause to paralyse, and can't take care of oneself, very then life-threatening.
" logical pain is theoretical " of " pain gate control theory --- pain nerve control theory " and Chinese medicine that nineteen sixty-five occurs Pain, which is prevented and treated, for the mankind is made that indelible contribution.There are many measures or method for tackling pain both at home and abroad at present, but all It is to be directed to have the Acute Pain effect of the definite cause of disease preferable.In clinical method therefor, drug dispel pain it is the most frequently used, in addition to this, push away Take, massage, thermotherapy, the physical therapies such as acupuncture and electrotherapy also can be relieved pain or uncomfortable symptom, in addition, there are also analgesic outer Section's operative treatment but this will using body by possible permanent damage as cost.In drug therapy, existing Western medicine also has Chinese medicine, existing outer With also there is interior use, but main or Western medicine and interior use.Common Western medicine anodyne mainly has non-steroidal anti-inflammatory drugs and central to stop Two class of pain medicine.Common non-steroidal analgesic medicine has aspirin, brufen, indocin, paracetamol etc.；Central anodyne has Pethidine, narcoticness morphine, Sauteralgyl etc.；Antianxiety class anodyne is such as stable.In addition, there are also relieving spasm and pain medicine such as atropics Product, pro-banthine, Semen daturae tablet, anisodamine etc..Common Chinese medicine has to have the Chinese herbal medicine of relaxing tendons and activating collaterals, acupuncture-stimulating blood stasis dispersing characteristic and be Pill, liquid medicine made of raw material etc..In addition, still having containing in or/and the external applications system such as the plaster type patch of western medicine composition and spray Agent.Above-mentioned all methods, operation therapy nocuity is big, and physical therapy effect is limited, although western modern medicine good effect toxic side effect Greatly, such as easily addicted, arteriosclerotic kidney, necrosis of renal papillae, renal insufficiency can be caused；Gastric mucosa is stimulated, serious stomach is caused Intestines reaction, induces gastric ulcer or even gastrorrhagia and perforation；Hepatic lesion；Allergic reaction；There is central nervous system symptom, such as head Bitterly, dizziness etc.；The problems such as easily there is drug tolerance, be suitable only for short-period used.TCM Therapy is for treating neck, shoulder, waist and leg Though pain has certain curative effect, it is the subsequent supplement of nutrition needed for lacking cell using relaxing tendons and activating collaterals, activating microcirculation and removing stasis medicinal as advantage, difficult To tackle the problem at its root, moreover, also will appear diversified toxic side effect as Western medicine.On the other hand, plaster type The topical classes preparation effect such as patch and spray is limited not to say also there is the defects of easy allergy, inconvenient for use mostly.
In short, with advances in technology with the improvement of people's living standards and the enhancing of health care consciousness, for neck shoulder waist This persistent ailment of skelagia, either based on therapeutic purposes, or be based on health purpose, it is necessary to develop it is new, using it is convenient, treat Effect is more preferable, using safe new product, constantly to promote people's lives quality.
Summary of the invention
The application is designed to provide a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, the production Product, which are directed to, back caused by many reasons or unknown reason, shoulder neck four limbs, joint and whole-body muscular pain or unknown pain Significant curative effect, or pain aching and tired stiff to the neck, shoulder, waist and leg muscle because caused by catch cold dampness or muscles and bones are strained or overwork etc. Malaise symptoms also have obvious reparation or rehabilitative action, the neck, shoulder, waist and leg joint for being sprayed at normal healthy people also to have certain guarantor Strong effect.
Details are as follows for the technical solution that the application is taken.
A kind of to treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which includes that pain biology slows down Agent, promoting blood circulation and removing obstruction in channels dose, joint biological lubricants, tendon muscle strengthener, cell physiological function conditioner and cell normal growth It is metabolized required agent, under preferable case, which further includes preservative；In further preferred situation, which further includes this The acceptable safety barrier of preparation or auxiliary material；
The pain biology slows down agent, including but not limited to Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract With rhizome of chuanxiong extract, one of or several arbitrary proportion mixtures may be selected；
Described promoting blood circulation and removing obstruction in channels dose, including but not limited to Notogineng Extract, notoginseng total saponin/glycosides, VB12, may be selected it is one of or Several arbitrary proportion mixtures；
The joint biological lubricants, including but not limited to chondroitin sulfate, hyaluronic acid or/and hyaluronate, polyglutamic One of or several arbitrary proportion mixtures may be selected in acid or/and polyglutamate；
The tendon muscle strengthener, including but not limited to collagen, collagen peptide, glutamine, inositol, calcium phosphate and One of or several arbitrary proportion mixtures may be selected in calcium gluconate；
The cell physiological function conditioner, including but not limited to ATP disodium, cromoci, trehalose, allantoin, ox sulphur One of or several arbitrary proportion mixtures may be selected in acid, vitamins and coenzyme substance；
The cell normal growth is metabolized required agent, including but not limited to amino acids, carbohydrate, organic acid substance, may be selected One of or several arbitrary proportion mixtures；
The preservative should be food grade preservative, including but not limited to potassium sorbate, dehydroactic acid sodium, potassium cinnamate, Radix Glycyrrhizae One of or several arbitrary proportion mixtures may be selected in acid, glycyrrhetate, propionate；
The acceptable safety barrier of described preparation or auxiliary material, the including but not limited to polyethylene glycol of different molecular weight size (PEG), one of or several arbitrary proportion mixtures may be selected in the polyvinylpyrrolidone (PVP) of different molecular weight size；
The polyethylene glycol of the different molecular weight size refers to that the molecular weight of food-grade or more is the poly- second of 400-20000 dalton Glycol；
The PVP of the different molecular weight size include but is not limited to the PVP K15 of pharmaceutical grade or more, PVP K30, PVP K60 and One of or several arbitrary proportion mixtures may be selected in PVP K90.
The total mass concentration of effective ingredient in a kind of complexing agent treated neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons For 0.5-38.0%；Each composition is in terms of mass fraction in effective ingredient, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 1-80.0, achyranthes bidentata extract 0.01-9.0, Rhizoma Gastrodiae extract 0.01-6.0, rhizome of chuanxiong extract 0.01-6.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 0.001-10.0, notoginseng total saponin/glycosides 0.001-2.0, VB12 0.001-10.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid The hyaluronic acid of chondroitin 0.001-12, the hyaluronic acid of high molecular weight or/and hyaluronate 0.001-5.0, middle-molecular-weihydroxyethyl Or/and the hyaluronic acid or/and hyaluronate 0.001-10.0 of hyaluronate 0.001-8.0, low molecular weight；High molecular weight Polyglutamic acid or/and polyglutamate 0.001-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.001- 6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.001-12.0；
The high molecular weight hyaluronic acid, high molecular weight hyaluronic acid salt refer to that molecular weight is greater than 2,400,000 (2400000) dalton；
The middle-molecular-weihydroxyethyl hyaluronic acid, middle-molecular-weihydroxyethyl hyaluronate refer to that molecular weight is greater than 1,000,000 (1000000), but do not surpass Cross 1,800,000 (1800000) dalton；
The low-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid salt refer to molecular weight no more than 400,000 (400000) dalton；
The high molecular weight polyglutamic acid, high molecular weight polyglutamate refer to that molecular weight is greater than 1,400,000 (1400000) dalton；
The middle-molecular-weihydroxyethyl polyglutamic acid, middle-molecular-weihydroxyethyl polyglutamate refer to that molecular weight is greater than 600,000 (600000), but are no more than 1200000 (1200000) dalton；
The low molecular weight polyglutamic acid, low molecular weight polyglutamate refer to molecular weight no more than 300,000 (300000) dalton；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 0.001-10.0, collagen peptide 0.001-12.0, glutamine 0.01-8.0, inositol 0.01-6.0, calcium phosphate 0.01-5.0, calcium gluconate 0.01-4.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 0.01-5.0, cromoci 0.001-5.0, trehalose 0.01- 9.0, allantoin 0.001-2.0, taurine 0.01-5.0；Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, cigarette Amide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, vitamin D 0.001-1.0,Ve 0.001-1.0；Biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, coenzyme II 0.001-2.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid substance, specifically: smart ammonia Sour 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, alanine 0.001-6.0, Proline 0.001-12.0, hydroxyproline 0.001-4.0, lysine 0.001-12.0, sodium glutamate 0.01-3.0；Glucose 0.001-6.0, sucrose 0.001-6.0；Tartaric acid 0.01-5.0, malic acid 0.01-5.0, citric acid 0.01-5.0, lactic acid 0.01-5.0, lactate 0.01-5.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.01-2.0, dehydroactic acid sodium 0.01-2.0, potassium cinnamate 0.01-2.0, glycyrrhizic acid 0.01-1.0, sweet Oxalates 0.01-3.0, propionate 0.01-2.0；
The glycyrrhetate is one or both of potassium glycyrrhizana, sodium glycyrrhetate arbitrary proportion mixture；
The propionate is one or both of sodium propionate, calcium propionate arbitrary proportion mixture；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 0.001-12.0, PVP 0.001-10.0.
It is described it is a kind of treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, in optimization formula, effective ingredient Total mass concentration is 1.0-36.0%；Each composition is in terms of mass fraction in effective ingredient, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 2-76.0, achyranthes bidentata extract 0.01-8.0, Rhizoma Gastrodiae extract 0.01-5.0, rhizome of chuanxiong extract 0.01-5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 0.01-10.0 notoginseng total saponin/glycosides 0.01-2.0, VB12 0.01-10.0；
The joint biological lubricants, by chondroitin sulfate, the hyaluronic acid or/and hyalomitome of high, normal, basic 3 kinds of different molecular weights The polyglutamic acid or/and polyglutamate of hydrochlorate and high, normal, basic 3 kinds of different molecular weights are constituted, specifically: chondroitin sulfate 0.01-11, the hyaluronic acid of high molecular weight or/and hyaluronate 0.01-4.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and transparent The hyaluronic acid or/and hyaluronate 0.01-8.0 of matter hydrochlorate 0.01-6.0, low molecular weight；
The polyglutamic acid or/and polyglutamic acid of the polyglutamic acid or/and polyglutamate 0.01-3.0 of high molecular weight, middle-molecular-weihydroxyethyl Salt 0.01-5.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.01-10.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 0.01-8.0, collagen peptide 0.01-10.0, glutamine 0.01-7.0, inositol 0.01-5.0, calcium phosphate 0.01-4.0, calcium gluconate 0.01-3.0；
The cell physiological function conditioner has important regulative to the physiological function of body muscle cell, by ATP bis- Sodium, cromoci, trehalose, allantoin, taurine, vitamins and coenzyme substance are constituted, specifically: ATP disodium 0.01-4.0, cromoci 0.001-4.0, trehalose 0.01-8.0, allantoin 0.01-2.0, taurine 0.01-4.0；Dimension Raw element VB1 0.01-5.0, vitamin V B2 0.01-1.0, niacinamide 0.01-9.0, VB5 0.01-5.0, VB6 0.01-5.0, Niacin 0.01-4.0, Vc 0.01-4.0, vitamin D 0.01-1.0, Ve 0.01-1.0；Biotin 0.002-1.0, coenzyme Q10 0.002-1.0, Coenzyme I 0.002-2.0, Coenzyme I I 0.002-2.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid substance, specifically: smart ammonia Sour 0.001-4.0, serine 0.001-4.0, glycine 0.001-8.0, glutamic acid 0.002-1.0, alanine 0.01-6.0, dried meat Propylhomoserin 0.001-10.0, hydroxyproline 0.01-4.0, lysine 0.001-10.0, sodium glutamate 0.01-2.0；Glucose 0.001-5.0, sucrose 0.001-5.0；Tartaric acid 0.01-4.0, malic acid 0.01-4.0, citric acid 0.01-4.0, lactic acid 0.01-4.0, lactate 0.01-4.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.02-2.0, dehydroactic acid sodium 0.02-2.0, potassium cinnamate 0.02-2.0, glycyrrhizic acid 0.02-1.0, sweet Oxalates 0.01-2.0, propionate 0.02-2.0；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 0.001-10.0, PVP 0.001-8.0.
A kind of complexing agent treated neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons can be liquid in terms of dosage form Preparation or solid formulation, it is preferred to use water gelling agent, more preferably spray or liniment, consequently facilitating using.
A kind of complexing agent for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, when specifically used, with gelling agent For preparation, 0.5-2ml/ times, this product is applied to affected part, gently massage a moment to skin absorbs completely, 1-3 times/day, can drink Feelings increase and decrease access times and dosage.
A kind of preparation method of complexing agent treated neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, specifically includes following step It is rapid:
(1) effective ingredient in complexing agent is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically:
First group, macromolecular saccharide compound, protein and peptide compound specifically have: collagen, collagen peptide, sulfuric acid Chondroitin, the hyaluronic acid of high, normal, basic 3 kinds of different molecular weights or/and hyaluronate and polyglutamic acid or/and polyglutamate；
Second group, amino acids, small molecule carbohydrate, organic acid specifically have: arginine, serine, glycine, glutamic acid, paddy Glutamine, alanine, proline, hydroxyproline, lysine；Glucose, trehalose, sucrose；Tartaric acid, malic acid, citric acid, Lactic acid, lactate, calcium gluconate；
Third group, vitamin coenzymes class compound, specifically has: vitamin V B1, vitamin V B2, niacinamide, VB5, VB6, niacin, Vc, vitamin D, Ve；Biotin, Co-Q10, Coenzyme I, Coenzyme I I, VB12；
4th group, unclassified stores specifically has: ATP disodium, cromoci, allantoin, taurine, inositol, Notogineng Extract, three Seven Total saponins/glycosides, potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate, propionate；Polyethylene glycol (PEG) With polyvinylpyrrolidone (PVP), Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong extract；
(2) second group of material weighed in step (1) is placed in reaction kettle, then be added part formulation amount solvent (such as Water), stirring and dissolving mixes, and stands, and mixture A is obtained after removal of impurities；
(3) third group weighed in step (1) and the 4th group of material are placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mix, and stand, and mixture B is obtained after removal of impurities；
(4) the mixture B of step (3) is slowly added into the mixture A of step (2), after the completion of addition, is added step (1) In weighed first group of material component, be eventually adding the solvent of remainder formula ratio, dissolution mixes, filtering and impurity removing, adjust pH= 3.5 ~ 6.5, this is complexing agent product provided herein.
Step (2), step (3), when carrying out dissolution in step (4) and mixing operation, operation temperature should not be greater than 45 DEG C, in order to avoid The stability and product quality of drug effect are influenced, but is also not lower than 15 DEG C, in order to avoid influence dissolution and mixed effect, preferably 25 DEG C of left sides It is right to carry out dissolution mixing operation.
Step (2), step (3), when carrying out dissolution in step (4) and mixing operation, it is preferred to use the homogeneous under vacuum condition Emulsifying manner is operated, and can preferably ensure mixed effect.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract contains the component of following mass fraction and by following process It is made: 30~90 parts of the rhizome of davallia, 40~75 parts of radix achyranthis bidentatae, 30~60 parts of Rhizoma Gastrodiae, 40~75 parts of rhizome of chuanxiong, 30~90 parts of Cortex Eucommiae, safranine Spend 30~90 parts, 40~75 parts of pueraria lobata, 40~75 parts of Radix Salviae Miltiorrhizae, 20~55 parts of Radix Astragali, 30~60 parts of Radix Notoginseng, 10~50 parts of Radix Angelicae Sinensis, 30~70 parts, 15~70 parts of schizonepeta, 20~80 parts of peppermint, 15~50 parts of the root of Dahurain angelica, 15~50 parts of caulis akebiae of radix saposhnikoviae；Its preparation process side Method includes: to weigh the formula Chinese medicine, is crushed to the particle that partial size is grain of rice size, and addition is equivalent to 5-20 times of quality of mixture Concentration be 10-90%(V/V) ethyl alcohol, then more in including but not limited to vacuum or/and normal pressure or/and positive pressure environment Set temperature is extracted more than a few hours under the conditions of being 20-75 DEG C in function extractor, and extracting solution is collected by filtration up to the alcohol extracting Liquid.
The major design that complexing agent provided herein functions is theoretical are as follows: theoretical to existing analgesic --- it cures in west The advantage of " logical pain theory " of " pain gate control theory --- the pain nerve cybernetics " and Chinese medicine learned, shortcoming and deficiency After comparative studies, by carefully studying and analyzing to pain phenomenon and symptom and producing cause and existing treatment means, it is based on The logical pain of traditional Chinese medicine is theoretical --- and " imitating in Transdermal absorption, external application " of-i.e. general rules do not hurt, pain is not unreasonable and modern medicine is theoretical, with The tendon and vessel dystrophy and integration of drinking and medicinal herbs of life science and food science and motherland's medicine are theoretical, design, develop one kind and have Promoting blood circulation and removing obstruction in channels, dispelling wind and eliminating dampness, cold extermination toxin expelling, relaxing muscles and tendons are good for network, strengthening the muscles and bones, putrefaction-removing granulation-promoting, anti-inflammatory health care, nourish nerve and muscle The safe and efficient and multicomponent targeting preparation that has no toxic side effect, preliminary application verification shows complexing agent provided herein Not only there is back, shoulder neck four limbs, joint and whole-body muscular pain or unknown pain caused by treatment many reasons or unknown reason The effect of pain, also can reduce with alleviate because suffer from cold catch cold dampness or muscles and bones strain or neck, shoulder, waist and leg muscle caused by overworking it is sour The malaise symptoms such as stiff or pain are stranded, meanwhile, also have and whole body neuromuscular cell function and micro- blood circulation system are adjusted The effect of reason, rehabilitation and activation, the old pain of injury of rehabilitation many years ago.
In general, compared with traditional treatment pain product or technical method, the present invention has following outstanding feature:
(1) compared with traditional treatment pain medication, said preparation is free of any pair of human body toxic side effect or harmful ingredient, it It is that a kind of for body can provide the targeting preparation of a variety of nutrition, health care, conditioning or rehabilitation and therapeutic effect；With " it is promoting blood circulation and removing obstruction in channels, Dispelling wind and eliminating dampness, cold extermination toxin expelling, relaxing muscles and tendons are good for network, strengthening the muscles and bones, putrefaction-removing granulation-promoting, anti-inflammatory health care, nourish nerve and muscle " etc. a variety of function Energy；
(2) product of the present invention is different from the dosage form and administration mode of the Western medicine of traditional treatment pain or Chinese medicine, traditional treatment pain Western medicine or the dosage form of Chinese medicine be mostly oral agents and injection, the dose for reaching lesion significantly reduces, it is difficult to hide the " first of liver Cross effect ", side effect is more, and product of the present invention is external preparation, does not have not only " first pass effect ", also with the spy of " guided missile drug " Point belongs to target administration, and not only dosage is greatly reduced, and effect is not only significant but also direct and has quick-acting；In addition, it uses prescription Formula is simple and convenient, can use whenever and wherever possible, good patient compliance；
(3) health status of neck, shoulder, waist and leg muscle and function can also be examined and tentatively judged using invention formulation；Specifically sentence Periodically, complexing agent provided herein is sprayed into body surface massage in a moment, if neck, shoulder, waist and leg muscle and functional health are disease-free, just Do not have abnormal sensory and reaction；It dampness or muscles and bones strain or overworks if having inflammatory pain or catching cold and causes muscle rigidity stiff Hard equal malaise symptoms, then embrocate position or its nearby mostly will appear fever, it is hot, itch, rubescent or eruption phenomena such as, have Occur rapidly, some is different due to the weight of illness with occurring several times or after a few days, and above-mentioned phenomenon generally occurs in old for many years hurt It can be later；
(4) the preparation method mild condition of invention formulation, simple process, non-environmental-pollution can be made at normal temperature or low temperature It is standby；
(5) the effect of product of the present invention existing drug, and there is the safety of the health food and cosmetics that can be repeatedly used for a long. Though product of the present invention is externally applied product, its safety both can reach interior (oral) health food (existing adjusting body function Effect, will not also generate any acute, subacute or chronic hazard to human body) standard, meanwhile, also complying with can long-term external application The country such as " cosmetics safety technical specification " or international standard；It is thus highly-safe.
Specific embodiment
Explanation is further explained to the application below with reference to embodiment.
Embodiment 1
The present embodiment provides a kind of complexing agent for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, which is liquor, The total mass concentration of effective ingredient is 8%, and surplus is water；Each composition is in terms of mass fraction in effective ingredient, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 40.0, achyranthes bidentata extract 5.0, Rhizoma Gastrodiae extract 3.0, rhizome of chuanxiong mention Take object 3.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 5.0, notoginseng total saponin/glycosides 0.5, VB12 5.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid Chondroitin 6.0, the hyaluronic acid 2.0 of high molecular weight, the Sodium Hyaluronate 4.0 of middle-molecular-weihydroxyethyl, low molecular weight Sodium Hyaluronate 5.0；The polyglutamic acid sodium 2.0 of high molecular weight, the polyglutamic acid 3.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 6.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 5.0, collagen peptide 6.0, glutamine 4.0, inositol 3.0, calcium phosphate 3.0, glucose Sour calcium 2.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 2.5, cromoci 2.5, trehalose 4.5, allantoin 1.0, ox sulphur Acid 2.5；Vitamin V B1 3.0, vitamin V B2 0.5, niacinamide 5.0, VB5 3.0, VB6 3.0, niacin 2.5, Vc 2.5, dimension Raw element D 0.5, Ve 0.5；Biotin 0.5, Co-Q10 0.5, Coenzyme I 1.0, Coenzyme I I 1.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 2.5, serine 2.5, glycine 4.5, glutamic acid 0.5, alanine 3.0, proline 6.0, hydroxyproline 2.0, lysine 6.0, Sodium glutamate 1.5；Glucose 3.0, sucrose 3.0；Tartaric acid 2.5, malic acid 2.5, citric acid 2.5, lactic acid 2.5, sodium lactate 2.5, calcium lactate 0.5；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 1.0, dehydroactic acid sodium 1.0, potassium cinnamate 1.0, glycyrrhizic acid 0.5, potassium glycyrrhizana 0.5, Carbenoxolone Sodium 1.5, sodium propionate 1.0, calcium propionate 1.0；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 400 6.0, Macrogol 4000 2.0, polyethylene glycol 10000 2.0, PEG 20000 2.0, PVP K15 2.0, PVP K30 1.0, PVP K60 0.5 and PVP K90 3.0.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract contains the component of following mass fraction and by following process It is made: 60 parts of the rhizome of davallia, 55 parts of radix achyranthis bidentatae, 45 parts of Rhizoma Gastrodiae, 50 parts of rhizome of chuanxiong, 60 parts of Cortex Eucommiae, 60 parts of safflower, 55 parts of pueraria lobata, Radix Salviae Miltiorrhizae 55 parts, 35 parts of Radix Astragali, 45 parts of Radix Notoginseng, 35 parts of Radix Angelicae Sinensis, 50 parts, 50 parts of schizonepeta, 50 parts of peppermint, 35 parts of the root of Dahurain angelica, 30 parts of caulis akebiae of radix saposhnikoviae； Its process of preparing includes: to weigh the formula Chinese medicine, is crushed to the particle that partial size is grain of rice size, and addition is equivalent to mixing The concentration of 5-20 times of quality of object is the ethyl alcohol of 10-90%(V/V), and then set temperature is 20-75 DEG C of item in multi-functional extractor It is extracted more than a few hours under part, extracting solution is collected by filtration up to the alcohol extract.
It is a kind of provided by the present embodiment to treat neck-shoulder pain, lumbago and leg pain and have the preparation method that strengthening tendons are good for the complexing agent of network function, Specifically include following processing step:
(1) effective ingredient in complexing agent is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically:
First group, macromolecular saccharide compound, protein and peptide compound specifically have: collagen, collagen peptide, sulfuric acid Chondroitin, the hyaluronic acid of high, normal, basic 3 kinds of different molecular weights or/and hyaluronate and polyglutamic acid or/and polyglutamate；
Second group, amino acids, small molecule carbohydrate, organic acid compound specifically have: arginine, serine, glycine, paddy Propylhomoserin, glutamine, alanine, proline, hydroxyproline, lysine；Glucose, trehalose, sucrose；Tartaric acid, malic acid, Citric acid, lactic acid, lactate, calcium gluconate；
Third group, vitamin coenzymes class compound, specifically has: vitamin V B1, vitamin V B2, niacinamide, VB5, VB6, niacin, Vc, vitamin D, Ve；Biotin, Co-Q10, Coenzyme I, Coenzyme I I, VB12；
4th group, unclassified stores, specifically has: ATP disodium, cromoci, allantoin, taurine, inositol, Radix Notoginseng in addition to the solvents Total saponin/glycosides, potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate, propionate；Polyethylene glycol (PEG) and Polyvinylpyrrolidone (PVP)；
(2) second group of material weighed in step (1) is placed in reaction kettle, the solvent of part formulation amount, stirring is then added Dissolution mixes, and stands, and mixture A is obtained after filtering and impurity removing；
(3) third group weighed in step (1) and the 4th group of material are placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mix, and stand, and mixture B is obtained after filtering and impurity removing；
(4) the mixture B of step (3) is slowly added into the mixture A of step (2), after the completion of addition, is added step (1) In weighed first group of material component, be eventually adding the solvent and auxiliary agent of remainder formula ratio, dissolution mixes, filtering and impurity removing, PH=5.0 are adjusted, this is complexing agent product provided herein；
Step (2), step (3), when carrying out dissolution in step (4) and mixing operation, 30 DEG C of operation temperature or so carry out dissolution mixing Operation；It is operated simultaneously using the emulsifying mode under vacuum condition, can preferably ensure mixed effect.
To the safety indexes such as the skin irritation of complexing agent product prepared by the present embodiment and pollutant (heavy metal) into Detection is gone, as a result (items Testing index listed by table 1,2 is by can often eat (use) as shown in the following table 1, table 2 The safe standard GB/T 16740-2014 of health food and " cosmetics safety technical specification " (version in 2015) new standard are held Row).
1 skin irritation of table and pollutant (heavy metal) testing result
Note: a refers to GB 16740-2014 national food safety standard-health food safety standard；B refers to state food drug The new edition " cosmetics safety technical specification " (version in 2015) (2015 No. 268) that supervision and management general bureau promulgates.The institute of table 1 and 2 Arrange every Testing index be by the safe standard GB/T 16740-2014 of the health food that can often eat (uses) with " cosmetics safety technical specification " (version in 2015) new standard executes.
2 microbiological indicator of table
The detection knot of the safety indexes such as the pollutants such as heavy metal of invention formulation and microorganism it can be seen from table 1 and 2 Fruit, not only comply fully with can the frequent edible safe standard GB/T 16740-2014 of health food repeatedly, also being compliant with can be with Newest " cosmetics safety technical specification " (version in 2015) standard of frequent Reusability.
For this dosage form product of complexing agent liquor prepared by the present embodiment, inventor has carried out the application examination of part actual human body (being volunteer) is tested, detailed process is briefly discussed below.
To the application effect of the neck-shoulder pain, lumbago and leg pain patient made a definite diagnosis
The 250 neck-shoulder pain, lumbago and leg pain volunteer patients made a definite diagnosis are selected at random, wherein 128 people of male, 122 people of women, age 20- 73 years old, the course of disease -30 years 1 day was not equal, neck, shoulder, waist and leg pain degree is different, and the cause of disease is also more various, and synthesis has fatigue, rheumatism Wind-cold etc. is a variety of.
Usage: applying or be sprayed onto affected part for appropriate this product, gently massages a moment；Dosage: 0.5-2ml/ times, 1-3 times/ Day, 7-14 days/course for the treatment of (continuous uninterrupted use), spraying carried out efficacy evaluation after 2 months.
Efficacy assessment standard: referring to the phase of State Food and Drug Administration " new Chinese medicine guideline of clinical investigations " It is as follows to close standard formulation:
Recovery from illness: pain disappears；Effective: pain is substantially reduced or alleviates, or it is accidental for being mitigated by persistent pain；It is effective: pain Mitigated, or intermittent attack is switched to by persistent pain；Invalid: pain is without improvement or aggravates.
Statistical result shows: 163 (65.2%) is cured, it is effective 72 (28.8%), and it is effective 12 (4.8%), invalid 3 (1.2%), total effective rate 98.8%(P < 0.01).In addition statistical observation the result shows that: most patients spray have for 1 times it is obvious Effect is embrocated 3-5 days, and effect is more significant, and patients with mild pain or malaise symptoms disappear, part severe patient affected part or its is attached Closely will appear it is rubescent, fever, itch, epidermis rise erythema phenomena such as, continue spraying 10 days or so, above-mentioned phenomenon disappears substantially, pain Pain or malaise symptoms are cured substantially, achieve ideal effect.
Safety investigate: during medication, except some patients by this agent be sprayed into affected part occur it is rubescent, fever, itch, epidermis It rises outside the phenomenon that erythema etc. belongs to the eliminating dampness and expelling toxin reaction of human normal, has no other toxic side effects and adverse reaction.If incite somebody to action this Agent is sprayed at without pain then without any reaction.
To the healthcare applications effect of general health volunteer
Select 232 age 20-65 years old healthy volunteers at random, try out product of the present invention, check trier with rear health care Effect.
Usage: appropriate this product is applied or is sprayed onto neck, shoulder, waist and leg unilateral side or left side (limb) joint, the other side (limb) is as right According to, gently massage a moment；Dosage: 0.5-2ml/ times, 1-3 times/day, increase and decrease access times and use can be taken the circumstances into consideration according to hobby Amount, 7-14 days/course for the treatment of (continuous uninterrupted use), spraying carried out effective evaluation after 4 months.
Efficacy assessment standard: referring to the phase of State Food and Drug Administration " new Chinese medicine guideline of clinical investigations " Close standard formulation trier is divided into following 4 kinds of situations with rear effect:
A: feel that tendon connection is more compact, muscle is more strong；B: feel pleasant；C: feel general or insentience；D: feel difficult By.
Statistical result shows:: A 200 (86.2%), B 23 (9.9%), C 9 (3.9%), D 0 (0.0%), sense Feel that tendon is coupled more compact, more strong person and accounts for 86.2%, in addition feeling preferable person 9.9%, feels that difficult receptor is 0.0%, panesthesia Pleasant rate is 96.1%(P < 0.01), achieve ideal effect.
Safety is investigated: during being up to medication in 4 months, for selected general health volunteer, not yet being found Any toxic side effect and adverse reaction case.
Overall application effect shows: differing in size, the patient that neck, shoulder, waist and leg pain degree is different for the age, uses this hair Bright complexing agent carries out spraying treatment, the either aching and tired tetanic stiff or flesh of arteriosclerosis and obstruction of lower limbs, cervical vertebra pain, Low Back Pain muscle of many years Power is insufficient, or new hair neck, shoulder, waist and leg pain has apparent treatment and relaxation effect；It is first for newly sending out mild pain or discomfort Secondary spraying can experience apparent mitigation and relaxation effect or even pain or uncomfortable disappearance, and for the old wound of many years Bitterly, then spray it is several times or after a few days more will appear rubescent, fever is itched, and epidermis plays the clearing damp row that erythema etc. belongs to human normal Outside malicious reacting phenomenon, other any toxic side effects and adverse reaction are had no, continue spraying 1 week or so, above-mentioned phenomenon will disappear, Illustrate that the eliminating dampness and expelling toxin reaction of human normal is basically completed, pain or malaise symptoms are clearly better；And it is sprayed for healthy volunteer This agent is applied, then most of tendons that can obviously experience are coupled that more compact, muscle is more strong, do not find that other any poison are secondary and make With and adverse reaction.
For above-mentioned experiment, the part typical case situation of use process is briefly enumerated and is described below:
(1) Lee: female, 73 years old, certain government functionary was retired, and pain in waist and lower extremities more than 30 years, such as oral Chinese and Western of a variety of medical procedures of seeking help Though medicine is forced on etc. and can be relieved pain, long-term administration is needed, many side effects is generated so that can not adhere to, the present invention is used to produce Product, usage: applying or be sprayed onto affected part for appropriate this product, gently massages a moment；Dosage: 0.5-2ml/ times, 1-3 times/day, spraying After 2 days, severe redness at spraying, fever is itched, or even a bit be difficult to endure, but continue to spray, above-mentioned symptom is for 1 week Left and right will slowly mitigate, and taken an evident turn for the better using 2 weeks or so, be almost recovered using 8 weeks or so, feel that leg is also stronger Amount；
(2) Mr. Wang: male, 55 years old, certain college professor, leg was because riding a bicycle unexpected tumble injury, a variety of medical treatment of seeking help when being educated in the university Means such as take orally Chinese and Western medicine, acupuncture or force on and do not cure, over more than 30 years, just not saying other therapies are temporarily, the number forced on Amount also has 5000 or more, moreover, in recent ten years, even if big summer will also wear knee-pad because knee joint fearness is cool, using this certainly After invention product, plaster was not just pasted again, was also no longer padded up.Usage: appropriate this product is applied or is sprayed onto affected part, is gently massaged A moment；Dosage: after 0.5-2ml/ times, 1-3 times/day, spraying 5 days, severe redness at spraying, fever is itched, or even a little The insufferable feeling of youngster, but continue to spray, above-mentioned symptom left and right for 1 week just disappears, and there had using 2 weeks or so to be obviously good Turn, be almost recovered using 8 weeks or so, feels that leg is also more strong；
(3) Zhao: female, 50 years old, certain college professor, because occupation needs are for a long time bent over one's desk working, before more than 10 years must cervical spondylosis, Frequent neck aches or it is stiff feel bad, especially winter is even more serious, and such as oral Chinese and Western medicine of a variety of medical procedures of seeking help wears shield Neck etc. just no longer wears neck guard, does not also take medicine without positive effect from using after product of the present invention.Usage: by appropriate this product Affected part is applied or be sprayed onto, a moment is gently massaged；Dosage: it after 0.5-2ml/ times, 1-3 times/day, spraying 3 days, is seriously sent out at spraying Red, fever is itched, or even a bit insufferable feeling, but continues to spray, and above-mentioned symptom left and right for 1 week just disappears, It was taken an evident turn for the better using 2 weeks or so, was almost recovered using 4 weeks or so；
(4) Sun: male, 56 years old, certain government functionary,, must cervical spondylosis before more than 10 years because occupation needs are for a long time bent over one's desk working And Low Back Pain, especially winter are even more serious, such as oral Chinese and Western medicine of a variety of medical procedures of seeking help wears the equal nothing of neck guard, back belt Positive effect just no longer wears neck guard, back belt, does not also take medicine from using after product of the present invention.Usage: by appropriate this product Affected part is applied or be sprayed onto, a moment is gently massaged；Dosage: 0.5-2ml/ times, 1-3 times/day, there had using 2 weeks or so to be obviously good Turn, was almost recovered using 6 weeks or so；
(5) it is tall certain: male, 38 years old, usage: appropriate this product is applied or is sprayed using product of the present invention by certain company manager, health To neck shoulder waist left rear side, the other side (limb) gently massages a moment as control；Dosage: 0.5-2ml/ times, 1-3 times/day, even Continuous spraying 4 months, in addition to spraying side can obviously experience, tendon connection is more compact, muscle is more strong, and the other side is felt to be not so good as It sprays outside side, without any other abnormal sensory.
(6) poplar: female, 27 years old, usage: certain company clerk, health appropriate this product is applied using product of the present invention Or it is sprayed onto neck shoulder waist left rear side, the other side (limb) gently massages a moment as control；Dosage: 0.5-2ml/ times, 1-3 times/ Day, continuous spray 4 months, perceptual image skin care item were the same, were coupled more compact, muscle in addition to spraying side can obviously experience tendon More strong, the other side is felt outside not as good as spraying side, without any other abnormal sensory.
(7) willow, female, 26 years old, certain company manager, health, but because working time too long neck is aching and tired stiff, it uses Product of the present invention spray coating neck 1 time, gently massage a moment, just no longer aching and tired stiff.
(8) Chen, female, 24 years old, certain company clerk, health, but because working time too long waist is aching and tired stiff and has Mild pain, using product of the present invention spray coating neck 3 times, gently massage a moment, just no longer it is aching and tired it is stiff, also without feeling of pain Feel.
Embodiment 2
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 0.5% in the complexing agent, adjusts pH=3.5；Each composition is in effective ingredient with mass parts Number meter specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 1.0, achyranthes bidentata extract 0.01, Rhizoma Gastrodiae extract 0.01, rhizome of chuanxiong mention Take object 0.01；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 0.001, notoginseng total saponin/glycosides 0.001, VB12 1.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid Chondroitin 0.001, the hyaluronic acid 0.001 of high molecular weight, the Sodium Hyaluronate 3.0 of middle-molecular-weihydroxyethyl, low molecular weight hyalomitome Sour sodium 0.001；The polyglutamic acid sodium 0.001 of high molecular weight, the polyglutamic acid 0.001 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic Sour sodium 0.001；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 0.001, collagen peptide 0.001, glutamine 0.01, inositol 0.01, calcium phosphate 0.01, calcium gluconate 4.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins With coenzyme substance constitute, specifically: ATP disodium 0.01, cromoci 0.01, trehalose 0.01, allantoin 0.01, Taurine 0.01；Vitamin V B1 0.01, vitamin V B2 0.001, niacinamide 0.01, VB5 0.01, VB6 0.01, niacin 0.01, Vc 0.01, vitamin D 0.001, Ve 0.001；It is biotin 0.001, Co-Q10 0.001, Coenzyme I 0.001, auxiliary Enzyme II 0.001；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 0.001, serine 0.001, glycine 0.001, glutamic acid 0.001, alanine 0.001, proline 0.001, hydroxyproline 0.001, lysine 0.001, sodium glutamate 0.001；Glucose 0.001, sucrose 0.001；Tartaric acid 0.01, malic acid 0.01, Citric acid 0.01, lactic acid 0.01, sodium lactate 0.01, calcium lactate 0.01；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.01, dehydroactic acid sodium 0.01, potassium cinnamate 0.01, glycyrrhizic acid 0.01, potassium glycyrrhizana 0.01, sweet Sodium oxalate 0.01, sodium propionate 0.01, calcium propionate 0.01；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 400 0.001, Macrogol 4000 0.001, polyethylene glycol 10000 0.001, polyethylene glycol 20000 0.001, PVP K15 0.001, PVP K30 0.001, PVP K60 0.5 and PVP K90 0.001.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract contains the component of following mass fraction and by following process It is made: 30 parts of the rhizome of davallia, 40 parts of radix achyranthis bidentatae, 30 parts of Rhizoma Gastrodiae, 40 parts of rhizome of chuanxiong, 30 parts of Cortex Eucommiae, 30 parts of safflower, 40 parts of pueraria lobata, Radix Salviae Miltiorrhizae 40 parts, 20 parts of Radix Astragali, 30 parts of Radix Notoginseng, 10 parts of Radix Angelicae Sinensis, 30 parts, 15 parts of schizonepeta, 20 parts of peppermint, 15 parts of the root of Dahurain angelica, 15 parts of caulis akebiae of radix saposhnikoviae； Its process of preparing includes: to weigh the formula Chinese medicine, is crushed to the particle that partial size is grain of rice size, and addition is equivalent to mixing The concentration of 5-20 times of quality of object be 10-90%(V/V) ethyl alcohol, then in including but not limited to vacuum or/and normal pressure or/and just It is extracted more than a few hours under the conditions of set temperature is 20-75 DEG C in multi-functional extractor in pressure ring border, extracting solution is collected by filtration Up to the alcohol extract.
Embodiment 3
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 38% in the complexing agent, adjusts pH=6.5, gelling agent is made；In effective ingredient respectively at Part in terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 80.0, achyranthes bidentata extract 9.0, Rhizoma Gastrodiae extract 6.0, rhizome of chuanxiong mention Take object 6.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 10.0, notoginseng total saponin/glycosides 2.0, VB12 10.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid Chondroitin 12.0, the Sodium Hyaluronate 5.0 of high molecular weight, the Sodium Hyaluronate 8.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid Sodium 10.0；The polyglutamic acid sodium 4.0 of high molecular weight, the polyglutamic acid 6.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 12.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 10.0, collagen peptide 12.0, glutamine 8.0, inositol 6.0, calcium phosphate 5.0, grape Calciofon 0.01；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 5.0, cromoci 5.0, trehalose 9.0, allantoin 2.0, ox sulphur Acid 5.0；Vitamin V B1 6.0, vitamin V B2 1.0, niacinamide 10.0, VB5 6.0, VB6 6.0, niacin 5.0, Vc 5.0, Vitamin D 1.0, Ve 1.0；Biotin 1.0, Co-Q10 1.0, Coenzyme I 2.0, Coenzyme I I 2.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 5.0, serine 5.0, glycine 9.0, glutamic acid 1.0, alanine 6.0, proline 12.0, hydroxyproline 4.0, lysine 12.0, sodium glutamate 3.0；Glucose 6.0, sucrose 6.0；Tartaric acid 5.0, malic acid 5.0, citric acid 5.0, lactic acid 5.0, lactic acid Sodium 4.0, calcium lactate 1.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 2.0, dehydroactic acid sodium 2.0, potassium cinnamate 2.0, glycyrrhizic acid 1.0, potassium glycyrrhizana 2.90, glycyrrhizic acid Sodium 0.01, sodium propionate 2.0, calcium propionate 0.01；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 400 0.001, Macrogol 4000 11.0, polyethylene glycol 10000 0.001, polyethylene glycol 20000 0.001, PVP K15 0.001, PVP K30 0.001, PVP K60 0.5 and PVP K90 9.0.
Wherein, the Nantural non-toxic Chinese herbal medicine alcohol extract contains the component of following mass fraction and by following process It is made: 90 parts of the rhizome of davallia, 75 parts of radix achyranthis bidentatae, 60 parts of Rhizoma Gastrodiae, 75 parts of rhizome of chuanxiong, 90 parts of Cortex Eucommiae, 90 parts of safflower, 75 parts of pueraria lobata, Radix Salviae Miltiorrhizae 75 parts, 55 parts of Radix Astragali, 60 parts of Radix Notoginseng, 50 parts of Radix Angelicae Sinensis, 70 parts, 70 parts of schizonepeta, 80 parts of peppermint, 50 parts of the root of Dahurain angelica, 50 parts of caulis akebiae of radix saposhnikoviae； Its process of preparing includes: to weigh the formula Chinese medicine, is crushed to the particle that partial size is grain of rice size, and addition is equivalent to mixing The concentration of 5-20 times of quality of object be 10-90%(V/V) ethyl alcohol, then in including but not limited to vacuum or/and normal pressure or/and just It is extracted more than a few hours under the conditions of set temperature is 20-75 DEG C in multi-functional extractor in pressure ring border, extracting solution is collected by filtration Up to the alcohol extract.
Embodiment 4
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 3% in the complexing agent, adjusts pH=4.5, spray is made；In effective ingredient each composition with Mass fraction meter, specifically:
The pain biology slows down agent, is made of rhizome of chuanxiong extract, specifically: rhizome of chuanxiong extract 1.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, specifically: Notogineng Extract 2.0；
The joint biological lubricants are the polyglutamate of chondroitin sulfate, high molecular weight hyaluronic acid salt and low molecular weight, Specifically: chondroitin sulfate 3.0, the Sodium Hyaluronate 0.01 of high molecular weight, low molecular weight polyglutamic acid sodium 1.0；
The tendon muscle strengthener, is made of collagen peptide, specifically: collagen 2.0；
The cell physiological function conditioner, is made of trehalose, taurine and vitamin substances, specifically: trehalose 2.0, taurine 0.5；Vitamin V B1 1.0, vitamin V B2 0.05, niacinamide 0.5, VB5 0.5, VB6 0.5；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: glycine 2.0, proline 3 .0, hydroxyproline 0.5；
The preservative, is made of potassium sorbate, specifically: potassium sorbate 0.2；
The acceptable safety barrier of described preparation or auxiliary material, are made of, specifically: polyethylene glycol polyethylene glycol (PEG) 4000 3.0。
Embodiment 5
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 16% in the complexing agent, adjusts pH=5.5, condensation agent is made；In effective ingredient respectively at Part in terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 30.0, achyranthes bidentata extract 3.0, Rhizoma Gastrodiae extract 2.0, rhizome of chuanxiong mention Take object 2.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract and VB12, specifically: Notogineng Extract 4.0, VB12 4.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate is constituted, specifically: chondroitin sulfate 5.0, the hyaluronic acid 2.0 of high molecular weight, middle-molecular-weihydroxyethyl hyaluronic acid The Sodium Hyaluronate 4.0 of sodium 3.0, low molecular weight；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 4.0, collagen peptide 6.0, glutamine 3.0, inositol 1.0, calcium phosphate 1.0, glucose Sour calcium 1.0；
The cell physiological function conditioner is made of trehalose, allantoin, taurine, vitamins and coenzyme substance, tool For body: trehalose 4.0, allantoin 0.5, taurine 1.0；Vitamin V B1 2.0, vitamin V B2 0.1, niacinamide 3.0, VB5 1.0, VB6 1.0, niacin 0.6, Vc 1.0, vitamin D 0.1, Ve 0.1；Biotin 0.1, Co-Q10 0.1, Coenzyme I 0.1, Coenzyme I I 0.1；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 2.0, serine 2.0, glycine 4.0, glutamic acid 0.1, alanine 2.0, proline 6.0, hydroxyproline 1.0, lysine 6.0, Sodium glutamate 0.7；Glucose 2.0, sucrose 2.0；Tartaric acid 2.0, malic acid 2.0, citric acid 2.0, lactic acid 2.0, sodium lactate 2.0, calcium lactate 2.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.5, dehydroactic acid sodium 0.5, potassium cinnamate 0.5, glycyrrhizic acid 0.5, potassium glycyrrhizana 0.5, Carbenoxolone Sodium 0.5, sodium propionate 0.5, calcium propionate 0.5；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: PEG 20000 6.0 and PVP K90 4.0.
Embodiment 6
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 22% in the complexing agent, adjusts pH=4.0, gelling agent is made；In effective ingredient respectively at Part in terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 50.0, achyranthes bidentata extract 5.0, Rhizoma Gastrodiae extract 4.0, rhizome of chuanxiong mention Take object 4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 6.0, notoginseng total saponin/glycosides 1.2, VB12 6.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid Chondroitin 7.0, the hyaluronic acid 3.0 of high molecular weight, the Sodium Hyaluronate 5.0 of middle-molecular-weihydroxyethyl, low molecular weight Sodium Hyaluronate 6.0；The polyglutamic acid sodium 2.0 of high molecular weight, the polyglutamic acid 3.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 6.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 6.0, collagen peptide 9.0, glutamine 5.0, inositol 3.0, calcium phosphate 2.0, glucose Sour calcium 2.0；
The cell physiological function conditioner, by ATP disodium, trehalose, allantoin, taurine, vitamins and coenzyme class object Texture is at specifically: ATP disodium 2.0, trehalose 6.0, allantoin 0.8, taurine 2.0；Vitamin V B1 3.0, dimension life Plain VB2 0.4, niacinamide 6.0, VB5 3.0, VB6 3.0, niacin 0.8, Vc 3.0, vitamin D 0.4, Ve 0.5；Biotin 0.5, Co-Q10 0.5, Coenzyme I 0.5, Coenzyme I I 0.5；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 3.0, serine 3.0, glycine 6.0, glutamic acid 0.5, alanine 3.0, proline 9.0, hydroxyproline 2.0, lysine 9.0, Sodium glutamate 1.0；Glucose 3.0, sucrose 3.0；Tartaric acid 3.0, malic acid 3.0, citric acid 3.0, lactic acid 3.0, sodium lactate 0.1, calcium lactate 4.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 1.0, dehydroactic acid sodium 1.0, potassium cinnamate 1.0, glycyrrhizic acid 1.0, potassium glycyrrhizana 1.0, Carbenoxolone Sodium 1.0, sodium propionate 1.0, calcium propionate 1.0；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: Macrogol 4000 4.0, polyethylene glycol 10000 2.0, PEG 20000 6.0, PVP K30 2.0, PVP K60 2.0 and PVP K90 6.0.
Embodiment 7
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 32% in the complexing agent, adjusts pH=6.0, gelling agent is made；In effective ingredient respectively at Part in terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 70.0, achyranthes bidentata extract 7.0, Rhizoma Gastrodiae extract 5.0, rhizome of chuanxiong mention Take object 5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 8.0, notoginseng total saponin/glycosides 1.6, VB12 8.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid Chondroitin 9.0, the hyaluronic acid 4.0 of high molecular weight, the Sodium Hyaluronate 7.0 of middle-molecular-weihydroxyethyl, low molecular weight Sodium Hyaluronate 8.0；The polyglutamic acid sodium 3.0 of high molecular weight, the polyglutamic acid 5.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 9.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 8.0, collagen peptide 11.0, glutamine 7.0, inositol 5.0, calcium phosphate 4.0, grape Calciofon 3.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 4.0, cromoci 4.0, trehalose 8.0, allantoin 1.6, ox sulphur Acid 4.0；Vitamin V B1 5.0, vitamin V B2 0.8, niacinamide 8.0, VB5 5.0, VB6 5.0, niacin 4.0, Vc 4.0, dimension Raw element D 0.8, Ve 0.8；Biotin 0.8, Co-Q10 0.8, Coenzyme I 0.8, Coenzyme I I 0.8；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 4.0, serine 4.0, glycine 8.0, glutamic acid 0.9, alanine 5.0, proline 11.0, hydroxyproline 3.0, lysine 11.0, sodium glutamate 2.0；Glucose 5.0, sucrose 5.0；Tartaric acid 4.0, malic acid 4.0, citric acid 4.0, lactic acid 4.0, lactic acid Sodium 4.2, calcium lactate 0.1；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 1.7, dehydroactic acid sodium 1.7, potassium cinnamate 1.7, glycyrrhizic acid 1.6, potassium glycyrrhizana 1.8, Carbenoxolone Sodium 1.2, sodium propionate 1.8, calcium propionate 0.1；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: Macrogol 4000 10.0, polyethylene glycol 10000 1.0, PVP K60 7.0 and PVP K90 2.0.
The test evaluation method of reference implementation example 1, then select 210 at random the age 20-75 years old, the course of disease -35 years 1 day is not Deng the different volunteer of, neck, shoulder, waist and leg pain degree, 7 groups are set, every group of 30 volunteers, Application Example 1 ~ 7 respectively A kind of prepared complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, carries out spraying experiment.
Usage: applying or be sprayed onto affected part for appropriate this product, gently massages a moment；Dosage: 0.5-2ml/ times, 1-3 times/ Day, 7-14 days/course for the treatment of (continuous uninterrupted use), spraying carried out efficacy evaluation after 2 months.
The complexing agent effect that statistical result shows prepared by embodiment 1 is best, and total effective rate is 100.0%(P < 0.05)；It is real The complexing agent effect for applying the preparation of example 4 is worst, and total effective rate is 56.7%(P < 0.05)；It is other successively are as follows:
The total effective rate of embodiment 2 is 63.3%(P < 0.05)；The total effective rate of embodiment 3 is 93.3%(P < 0.05)；
The total effective rate of embodiment 5 is 73.3%(P < 0.05)；The total effective rate of embodiment 6 is 80.0%(P < 0.05)；
The total effective rate of embodiment 7 is 86.6%(P < 0.05).
Embodiment 8
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 6% in the complexing agent, adjusts pH=5.0, condensation agent is made；Each composition in effective ingredient In terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 60.0, achyranthes bidentata extract 8.0, Rhizoma Gastrodiae extract 0.5, rhizome of chuanxiong mention Take object 0.5；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 3.0, notoginseng total saponin/glycosides 0.7, VB12 3.0；
The joint biological lubricants, by the hyaluronic acid or/and hyaluronate and height of high, normal, basic 3 kinds of different molecular weight sizes In low 3 kinds of different molecular weight sizes polyglutamic acid or/and polyglutamate constitute, specifically: the hyalomitome of high molecular weight Sour sodium 2.0, the Sodium Hyaluronate 2.0 of middle-molecular-weihydroxyethyl, low molecular weight Sodium Hyaluronate 3.0；The polyglutamic acid sodium of high molecular weight 1.0, the polyglutamic acid 3.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 4.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 3.0, collagen peptide 4.0, glutamine 2.0, inositol 2.0, calcium phosphate 2.0, glucose Sour calcium 1.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 2.0, cromoci 2.0, trehalose 3.0, allantoin 0.7, ox sulphur Acid 0.8；Vitamin V B1 2.0, vitamin V B2 0.3, niacinamide 3.0, VB5 2.0, VB6 2.0, niacin 2.0, Vc 2.0, dimension Raw element D 0.3, Ve 0.3；Biotin 0.3, Co-Q10 0.3, Coenzyme I 0.7, Coenzyme I I 0.7；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 2.0, serine 2.0, glycine 3.0, glutamic acid 0.3, alanine 2.0, proline-4 .0, hydroxyproline 1.0, lysine 4.0, Sodium glutamate 1.0；Glucose 2.0, sucrose 2.0；Tartaric acid 2.0, malic acid 2.0, citric acid 2.0, lactic acid 2.0, sodium lactate 2.0, calcium lactate 2.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.3, dehydroactic acid sodium 0.3, potassium cinnamate 0.3, glycyrrhizic acid 0.3, potassium glycyrrhizana 0.3, Carbenoxolone Sodium 0.3, sodium propionate 0.3, calcium propionate 0.3；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 400 4.0, Macrogol 4000 2.0, polyethylene glycol 10000 4.0, PEG 20000 2.0, PVP K15 3.0, PVP K30 3.0, PVP K60 3.0 and PVP K90 1.0.
Embodiment 9
For a kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons, preparation provided by the present embodiment Method is with embodiment 1, and only adjustment member formula is as follows:
The total mass concentration of effective ingredient is 6% in the complexing agent, adjusts pH=5.0, condensation agent is made；Each composition in effective ingredient In terms of mass fraction, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, and specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 20.0, achyranthes bidentata extract 2.0, Rhizoma Gastrodiae extract 3.0, rhizome of chuanxiong mention Take object 4.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 7.0, notoginseng total saponin/glycosides 1.4, VB12 7.0；
The joint biological lubricants, by the hyaluronic acid or/and hyaluronate and height of high, normal, basic 3 kinds of different molecular weight sizes In low 3 kinds of different molecular weight sizes polyglutamic acid or/and polyglutamate constitute, specifically: the hyalomitome of high molecular weight Sour sodium 4.0, the Sodium Hyaluronate 6.0 of middle-molecular-weihydroxyethyl, low molecular weight Sodium Hyaluronate 7.0；The polyglutamic acid sodium of high molecular weight 3.0, the polyglutamic acid 5.0 of middle-molecular-weihydroxyethyl, low molecular weight polyglutamic acid sodium 8.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 7.0, collagen peptide 8.0, glutamine 6.0, inositol 4.0, calcium phosphate 3.0, glucose Sour calcium 0.01；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 4.0, cromoci 4.0, trehalose 7.0, allantoin 1.6, ox sulphur Acid 4.0；Vitamin V B1 4.0, vitamin V B2 0.6, niacinamide 7.0, VB5 4.0, VB6 4.0, niacin 4.0, Vc 4.0, dimension Raw element D 0.7, Ve 0.7；Biotin 0.7, Co-Q10 0.7, Coenzyme I 1.5, Coenzyme I I 1.5；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid, specifically: arginine 4.0, serine 4.0, glycine 7.0, glutamic acid 0.8, alanine 4.0, proline 8.0, hydroxyproline 3.0, lysine 8.0, Sodium glutamate 2.0；Glucose 4.0, sucrose 4.0；Tartaric acid 4.0, malic acid 4.0, citric acid 4.0, lactic acid 4.0, sodium lactate 4.0, calcium lactate 1.0；
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool For body: potassium sorbate 0.6, dehydroactic acid sodium 0.6, potassium cinnamate 0.6, glycyrrhizic acid 0.6, potassium glycyrrhizana 0.6, Carbenoxolone Sodium 0.6, sodium propionate 0.6, calcium propionate 0.6；
The acceptable safety barrier of described preparation or auxiliary material, by polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) structure At specifically: polyethylene glycol 400 8.0, Macrogol 4000 1.0, polyethylene glycol 10000 1.0, PEG 20000 2.0, PVP K15 1.0, PVP K30 5.0, PVP K60 1.0 and PVP K90 2.0.
The test evaluation method of reference implementation example 1, selects 120 the age 20-74 years old at random, and the course of disease -35 years 1 day is not Deng the different volunteer of, neck, shoulder, waist and leg pain degree, 2 groups are set, every group of 60 volunteers, Application Example 8, real respectively A kind of complexing agent product for treating neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons prepared by example 9 is applied, spraying experiment is carried out.
Usage: applying or be sprayed onto affected part for appropriate this product, gently massages a moment；Dosage: 0.5-2ml/ times, 1-3 times/ Day, 7-14 days/course for the treatment of (continuous uninterrupted use), spraying carried out efficacy evaluation after 2 months.
The complexing agent effect that statistical result shows prepared by embodiment 9 is best, and total effective rate is 96.7%(P < 0.05), implement Complexing agent effect prepared by example 8 is weaker than embodiment 9, and total effective rate is 88.3%(P < 0.05).
Comprehensive a large amount of practical application test results, can be with regard to the major advantage of complexing agent product provided herein or beneficial Effect sums up as follows:
(1) it mainly has the beneficial effect that targeting applies and rubs with the hands, absorbs rapidly, skin sense is pleasant, and effect is obvious；Maintenance combines, and is to support It is main；Outer diseases prevention enters, and inside repairs skin；There is disease that can disappear, it is ill-mannered to prevent；Spot printing sore spot, rubbing are easy to use；It is nontoxic, peace Overall height effect.It can be used for back caused by treating many reasons, shoulder neck four limbs, joint and whole-body muscular pain or unknown pain, or Because caused by suffering from cold and catch cold dampness skelagia, Low Back Pain, pain in my shoulder and neck pain or waist, leg, shoulder and neck muscle be aching and tired or the discomforts such as stiff Symptom, be mainly used for it is chronic caused by a variety of causes have a pain in the back, the mitigation of symptoms such as shoulder neck extremities joint pain, stiff neck and slow Solution, it is excellent for joint and muscle caused by the reasons such as tendon and vessel muscle dystrophy, neurodegenerative, genus of stiff vessel, function degeneration The malaise symptoms such as chronic ache or unknown pain or waist, leg, shoulder and neck muscle are aching and tired or stiff.Effect feature is, according to state of an illness weight Length, effect are different, primary to spray if mild pain or discomfort, pain or malaise symptoms can mitigate rapidly alleviation or It disappears, if newly sending out severe pain, general spraying 1-4 weeks, pain symptom can be substantially reduced or disappears, and also has the serious pain of new hair The case that 1-2 weeks pain symptom of pain coating just disappears；If medical history is longer, long period treatment and conditioning and rehabilitation are needed.
(2) highly-safe, it is widely applicable.Invention formulation has no toxic side effect, is non-stimulated, without allergy, is suitable for almost institute There is crowd.
(3) easy to use, excellent effect.Product of the present invention not only good effect, quick, treating both manifestation and root cause of disease, but also can be at any time It uses and can be used for a long time everywhere.Unlike traditional drug, it should not use there are many toxic side effect and limiting factor and long, and Health care professional is needed to instruct.
(4) to arteriosclerosis and obstruction of lower limbs, treating rheumatic ostealgia, due to external impacts caused by the sudden strain of a muscle many years ago the arthralgia and myalgias illness such as sprain Also there is good curative effect.Appearance is rubescent such as near affected part or its in use, and fever itches, erythema etc. is played on epidermis Phenomenon is the eliminating dampness and expelling toxin reaction of human normal.
(5) invention formulation not only has the function for the treatment of neck-shoulder pain, lumbago and leg pain, can also be to because of dampness or the muscles and bones strain of catching cold Or neck, shoulder, waist and leg muscle caused by overworking is aching and tired stiff or the malaise symptoms such as pain have good mitigation and relaxation effect, Meanwhile also have and whole body neuromuscular cell function and micro- blood circulation system improved, rehabilitation and activation the effect of, rehabilitation The old pains of injury such as sudden strain of a muscle strain many years ago.So invention formulation not only can treat neck-shoulder pain, lumbago and leg pain patient, also can be used as The daily health caring articles that ordinary people's strengthening tendons are good for network, keep fit and healthy.

Claims (10)

1. a kind of treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that the complexing agent includes pain Biology slows down agent, promoting blood circulation and removing obstruction in channels dose, joint biological lubricants, tendon muscle strengthener, cell physiological function conditioner and cell Normal growth is metabolized required agent；
The pain biology slows down agent, including but not limited to Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract With rhizome of chuanxiong extract, selection one of which or several arbitrary proportion mixtures；
Described promoting blood circulation and removing obstruction in channels dose, including but not limited to Notogineng Extract, notoginseng total saponin/glycosides, VB12, selection are one of or several Kind arbitrary proportion mixture；
The joint biological lubricants, including but not limited to chondroitin sulfate, hyaluronic acid or/and hyaluronate, polyglutamic Acid or/and polyglutamate, selection one of which or several arbitrary proportion mixtures；
The tendon muscle strengthener, including but not limited to collagen, collagen peptide, glutamine, inositol, calcium phosphate and Calcium gluconate, selection one of which or several arbitrary proportion mixtures；
The cell physiological function conditioner, including but not limited to ATP disodium, cromoci, trehalose, allantoin, ox sulphur Acid, vitamins and coenzyme substance, selection one of which or several arbitrary proportion mixtures；
The cell normal growth is metabolized required agent, including but not limited to amino acids, carbohydrate, organic acid substance, selects it Middle one or more arbitrary proportion mixture.
2. a kind of as described in claim 1 treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that should Complexing agent includes preservative；The preservative, including but not limited to potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, Glycyrrhetate, propionate, selection one of which or several arbitrary proportion mixtures.
3. a kind of as described in claim 1 treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that should Complexing agent includes acceptable safety barrier or auxiliary material；The acceptable safety barrier or auxiliary material, it is including but not limited to different The polyvinylpyrrolidone (PVP) of the polyethylene glycol (PEG) of molecular size range, different molecular weight size, selection it is one of or Several arbitrary proportion mixtures；
The polyethylene glycol of the different molecular weight size refers to that molecular weight is the polyethylene glycol of 400-20000 dalton；
The PVP of the different molecular weight size, including but not limited to PVP K15, PVP K30, PVP K60 and PVP K90, selection One of or several arbitrary proportion mixtures.
4. a kind of as described in claim 1 treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that multiple The total mass concentration of effective ingredient is 0.5-38.0% in mixture；Each composition is in terms of mass fraction in effective ingredient, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 1-80.0, achyranthes bidentata extract 0.01-9.0, Rhizoma Gastrodiae extract 0.01-6.0, rhizome of chuanxiong extract 0.01-6.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 0.001-10.0, notoginseng total saponin/glycosides 0.001-2.0, VB12 0.001-10.0；
The joint biological lubricants, by chondroitin sulfate, high, normal, basic 3 kinds of different molecular weight sizes hyaluronic acid or/and thoroughly Bright matter hydrochlorate and the polyglutamic acid or/and polyglutamate of high, normal, basic 3 kinds of different molecular weight sizes are constituted, specifically: sulfuric acid The hyalomitome of chondroitin 0.001-12.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.001-5.0, middle-molecular-weihydroxyethyl Acid or/and hyaluronate 0.001-8.0, the hyaluronic acid of low molecular weight or/and hyaluronate 0.001-10.0；Macromolecule Polyglutamic acid or/and polyglutamate 0.001-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.001- of amount 6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.001-12.0；
The high molecular weight hyaluronic acid, high molecular weight hyaluronic acid salt refer to that molecular weight is greater than 2,400,000 dalton；
The middle-molecular-weihydroxyethyl hyaluronic acid, middle-molecular-weihydroxyethyl hyaluronate refer to that molecular weight is greater than 1,000,000, but are no more than 1,800,000 Er Dun；
The low-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid salt refer to molecular weight no more than 400,000 dalton；
The high molecular weight polyglutamic acid, high molecular weight polyglutamate refer to that molecular weight is greater than 1,400,000 dalton；
The middle-molecular-weihydroxyethyl polyglutamic acid, middle-molecular-weihydroxyethyl polyglutamate refer to that molecular weight is greater than 600,000, but are no more than 1,200,000 dongles ?；
The low molecular weight polyglutamic acid, low molecular weight polyglutamate refer to molecular weight no more than 300,000 dalton；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 0.001-10.0, collagen peptide 0.001-12.0, glutamine 0.01-8.0, inositol 0.01-6.0, calcium phosphate 0.01-5.0, calcium gluconate 0.01-4.0；
The cell physiological function conditioner, by ATP disodium, cromoci, trehalose, allantoin, taurine, vitamins It is constituted with coenzyme substance, specifically: ATP disodium 0.01-5.0, cromoci 0.001-5.0, trehalose 0.01- 9.0, allantoin 0.001-2.0, taurine 0.01-5.0；Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, cigarette Amide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, vitamin D 0.001-1.0,Ve 0.001-1.0；Biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, coenzyme II 0.001-2.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid substance, specifically: smart ammonia Sour 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, alanine 0.001-6.0, Proline 0.001-12.0, hydroxyproline 0.001-4.0, lysine 0.001-12.0, sodium glutamate 0.01-3.0；Glucose 0.001-6.0, sucrose 0.001-6.0；Tartaric acid 0.01-5.0, malic acid 0.01-5.0, citric acid 0.01-5.0, lactic acid 0.01-5.0, lactate 0.01-5.0.
5. a kind of as claimed in claim 4 treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that multiple The total mass concentration of effective ingredient is 1.0-36.0% in mixture；Each composition is in terms of mass fraction in effective ingredient, specifically:
The pain biology slows down agent, is extracted by Nantural non-toxic Chinese herbal medicine alcohol extract, achyranthes bidentata extract, Rhizoma Gastrodiae extract and rhizome of chuanxiong Object is constituted, specifically: Nantural non-toxic Chinese herbal medicine alcohol extract 2-76.0, achyranthes bidentata extract 0.01-8.0, Rhizoma Gastrodiae extract 0.01-5.0, rhizome of chuanxiong extract 0.01-5.0；
It described promoting blood circulation and removing obstruction in channels dose, is made of Notogineng Extract, notoginseng total saponin/glycosides and VB12, specifically: Notogineng Extract 0.01-10.0 notoginseng total saponin/glycosides 0.01-2.0, VB12 0.01-10.0；
The joint biological lubricants, by chondroitin sulfate, the hyaluronic acid or/and hyalomitome of high, normal, basic 3 kinds of different molecular weights The polyglutamic acid or/and polyglutamate of hydrochlorate and high, normal, basic 3 kinds of different molecular weights are constituted, specifically: chondroitin sulfate 0.01-11.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.01-4.0, middle-molecular-weihydroxyethyl hyaluronic acid or/and thoroughly The hyaluronic acid or/and hyaluronate 0.01-8.0 of bright matter hydrochlorate 0.01-6.0, low molecular weight；
The polyglutamic acid or/and polyglutamic acid of the polyglutamic acid or/and polyglutamate 0.01-3.0 of high molecular weight, middle-molecular-weihydroxyethyl Salt 0.01-5.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.01-10.0；
The tendon muscle strengthener, by collagen, collagen peptide, glutamine, inositol, calcium phosphate and calcium gluconate It constitutes, specifically: collagen 0.01-8.0, collagen peptide 0.01-10.0, glutamine 0.01-7.0, inositol 0.01-5.0, calcium phosphate 0.01-4.0, calcium gluconate 0.01-3.0；
The cell physiological function conditioner has important regulative to the physiological function of body muscle cell, by ATP bis- Sodium, cromoci, trehalose, allantoin, taurine, vitamins and coenzyme substance are constituted, specifically: ATP disodium 0.01-4.0, cromoci 0.001-4.0, trehalose 0.01-8.0, allantoin 0.01-2.0, taurine 0.01-4.0；Dimension Raw element VB1 0.01-5.0, vitamin V B2 0.01-1.0, niacinamide 0.01-9.0, VB5 0.01-5.0, VB6 0.01-5.0, Niacin 0.01-4.0, Vc 0.01-4.0, vitamin D 0.01-1.0, Ve 0.01-1.0；Biotin 0.002-1.0, coenzyme Q10 0.002-1.0, Coenzyme I 0.002-2.0, Coenzyme I I 0.002-2.0；
The cell normal growth is metabolized required agent, is made of amino acids, carbohydrate, organic acid substance, specifically: smart ammonia Sour 0.001-4.0, serine 0.001-4.0, glycine 0.001-8.0, glutamic acid 0.002-1.0, alanine 0.01-6.0, dried meat Propylhomoserin 0.001-10.0, hydroxyproline 0.01-4.0, lysine 0.001-10.0, sodium glutamate 0.01-2.0；Glucose 0.001-5.0, sucrose 0.001-5.0；Tartaric acid 0.01-4.0, malic acid 0.01-4.0, citric acid 0.01-4.0, lactic acid 0.01-4.0, lactate 0.01-4.0.
6. a kind of as described in claim 1 treat neck-shoulder pain, lumbago and leg pain and have the complexing agent that strengthening tendons are good for network function, which is characterized in that institute Complexing agent is stated, is liquid formulation or solid formulation in terms of dosage form.
7. a kind of complexing agent treated neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons is preparing a kind for the treatment of as described in claim 1 Neck-shoulder pain, lumbago and leg pain has the application that strengthening tendons are good in network functional preparation simultaneously, which is characterized in that gel formulations are used, it is specifically used When, it is applied to affected part for 0.5-2ml/ times, 1-3 times/day.
8. a kind of preparation method of complexing agent treated neck-shoulder pain, lumbago and leg pain and have the strong network function of strengthening tendons described in claim 1, It is characterized in that, specifically comprises the following steps:
(1) effective ingredient in complexing agent is divided into 4 groups according to material properties and the convenience of preparation and easy property processed, weighs match respectively Dosage is spare in side, specifically:
First group, macromolecular saccharide compound, protein and peptide compound；
Second group, amino acids, small molecule carbohydrate, organic acid；
Third group, vitamin coenzymes class compound；
4th group, unclassified stores in addition to the solvents；
(2) second group of material weighed in step (1) is placed in reaction kettle, the solvent of part formulation amount, stirring is then added Dissolution mixes, and stands, and mixture A is obtained after removal of impurities；
(3) third group weighed in step (1) and the 4th group of material are placed in reaction kettle, the molten of part formulation amount is then added Agent, stirring and dissolving mix, and stand, and mixture B is obtained after removal of impurities；
(4) the mixture B of step (3) is slowly added into the mixture A of step (2), after the completion of addition, is added step (1) In weighed first group of material component, be eventually adding the solvent of remainder formula ratio, dissolution mixes, filtering and impurity removing, adjust pH= 3.5 ~ 6.5, this is complexing agent product provided herein.
9. a kind of as claimed in claim 8 treat neck-shoulder pain, lumbago and leg pain and have the preparation method that strengthening tendons are good for the complexing agent of network function, It is characterized in that, step (2), step (3), when carrying out dissolution in step (4) and mixing operation, operation temperature is not higher than 45 DEG C, not low In 15 DEG C；It is operated using the emulsifying mode under vacuum condition.
10. the pain biology as described in claim 1,4,5 slows down the Nantural non-toxic Chinese herbal medicine alcohol extract in agent, feature exists In component that the Nantural non-toxic Chinese herbal medicine alcohol extract contains following mass fraction is simultaneously made by following processes: bone is broken 30~90 parts of benefit, 40~75 parts of radix achyranthis bidentatae, 30~60 parts of Rhizoma Gastrodiae, 40~75 parts of rhizome of chuanxiong, 30~90 parts of Cortex Eucommiae, safflower 30~90 Part, 40~75 parts of pueraria lobata, 40~75 parts of Radix Salviae Miltiorrhizae, 20~55 parts of Radix Astragali, 30~60 parts of Radix Notoginseng, 10~50 parts of Radix Angelicae Sinensis, radix saposhnikoviae 30~ 70 parts, 15~70 parts of schizonepeta, 20~80 parts of peppermint, 15~50 parts of the root of Dahurain angelica, 15~50 parts of caulis akebiae；Its process of preparing includes: The formula Chinese medicine is weighed, the particle that partial size is grain of rice size is crushed to, the concentration for being equivalent to 5-20 times of quality of mixture is added For the ethyl alcohol of 10-90%(V/V), then in including that extract number under the conditions of set temperature is 20-75 DEG C in multi-functional extractor small When more than, extracting solution is collected by filtration up to the alcohol extract.
CN201810853763.9A 2018-07-30 2018-07-30 It is a kind of to treat neck-shoulder pain, lumbago and leg pain and have complexing agent and its preparation method that strengthening tendons are good for network function Pending CN108939077A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1839941A (en) * 2006-01-24 2006-10-04 赵福勤 Chinese prepared medicine for treating bone pain
CN101036677A (en) * 2007-04-02 2007-09-19 昆明制药集团股份有限公司 Compound panax notoginseng cataplasma
CN106728958A (en) * 2016-12-21 2017-05-31 四川何天祺医院管理有限公司 Pharmaceutical composition for treating muscles and bones arthralgia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1839941A (en) * 2006-01-24 2006-10-04 赵福勤 Chinese prepared medicine for treating bone pain
CN101036677A (en) * 2007-04-02 2007-09-19 昆明制药集团股份有限公司 Compound panax notoginseng cataplasma
CN106728958A (en) * 2016-12-21 2017-05-31 四川何天祺医院管理有限公司 Pharmaceutical composition for treating muscles and bones arthralgia

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