CN108926369A - A kind of occluder for left auricle and its assembly method being cross-linked - Google Patents
A kind of occluder for left auricle and its assembly method being cross-linked Download PDFInfo
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- CN108926369A CN108926369A CN201810480320.XA CN201810480320A CN108926369A CN 108926369 A CN108926369 A CN 108926369A CN 201810480320 A CN201810480320 A CN 201810480320A CN 108926369 A CN108926369 A CN 108926369A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
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- A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
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Abstract
The invention discloses a kind of occluder for left auricle and its assembly method being cross-linked, occluder for left auricle includes sealing interconnected and anchor portion, the reticular structure that there is the anchor portion cutting to be formed, the sealing and anchor portion are respectively provided with the interconnecting piece being made up of shape convergence, and the interconnecting piece of both sealing and anchor portion extends towards and the fixation that misplaces.The present invention realizes being cross-linked for sealing and anchor portion by improving connection type, can allow sealing and left auricle of heart attach even closer and blocks left auricle of heart opening, with the incidence of leakage and residual shunt in reducing.
Description
Technical field
The present invention relates to medical instruments, and in particular to a kind of for blocking the intervention therapeutic apparatus of left auricle of heart.
Background technique
Auricular fibrillation (abbreviation atrial fibrillation) is the most common perpetual arrhythmia.The incidence of atrial fibrillation is not with age
Disconnected to increase, crowd is up to 10% within 75 years old or more.The frequency of atrial impulses reaches 300-600 beats/min when atrial fibrillation, and palmic rate is often fast
And it is irregular, atrium loses effective contractile function.Left auricle of heart convergent force declines when atrial fibrillation, along with the shape of left auricle of heart itself
State feature and its interior trabecular muscles are rough and uneven in surface, so that blood flow generates whirlpool and flows decrease in left auricle of heart, promote thrombosis.
90% or more Non-valvular disease patients with atrial fibrillation left atrial thrombus is present in left auricle of heart.Brain can be entered by aorta vessel after thrombus breaks loose
Portion's arteries forms cerebral embolism, that is, cerebral apoplexy.
It is clinically main at present to carry out prophylactic treatment using three kinds of methods for the risk of patients with atrial fibrillation cerebral apoplexy, i.e., it is anti-
Solidifying drug therapy, surgical operation therapy and the treatment of percutaneous left atrial appendage occlusion.Anticoagulant treatment refers to by taking anticoagulant
Inhibit blood clotting, to reduce the risk of thrombosis in left auricle of heart, and then reduces the probability of happening of cerebral apoplexy.Clinical test
Show that anticoagulant treatment can significantly reduce the probability of happening of cerebral apoplexy, but anticoagulant treatment is a very long process,
There is also apparent complication simultaneously, are mainly shown as hemorrhage complication, and be likely to occur more serious situation.Surgical operation
Treatment includes surgical resection or suture left auricle of heart, but surgery operating wound is big, be usually expert at valve replacement or
It is completed when other operations such as coronary bypass, patient is generally difficult to receive simple left auricle of heart surgical operation, especially advanced age
Patient.Percutaneous left atrial appendage occlusion treatment refers to by way of percutaneous puncture, using the lesser delivery sheath of a diameter, by a left side
Atrial appendage occlusion device is transported to the left auricle of heart positioned at heart atrium dextrum and release.Occluder for left auricle can be by the aperture position of left auricle of heart
It blocks, blood flow not can enter left auricle of heart in atrium, therefore cannot form thrombus, to reach prevention auricular fibrillation thromboembolism
Purpose.Since 2001, percutaneous left atrial appendage occlusion treatment started to come into operation, and had successively carried out zoopery and clinical examination
It tests.Clinical test shows that left atrial appendage occlusion art can effectively reduce the probability of happening of patients with atrial fibrillation cerebral apoplexy.
Divide from structure, occluder for left auricle mainly divides two types currently on the market：Plug structure and double disk structure.
Because the application time of occluder for left auricle is relatively short, technology is relatively immature, postoperative to will appear some complication
Influence the quality of life of patient；Wherein instrument residual shunt is one of the major complications of left atrial appendage occlusion art, wherein with regard to plug
Structure, in terms of its 6 months Follow-up results, there are residual shunt complication, the Follow-up results from 12 months are shown 8% patient,
There are the residual shunt complication of certain degree by the patient at different centers 32%~34.5%；And the left atrial appendage occlusion of double disk structure
Device, the 6 months clinical follow up results in different centers see that there are moderate residual shunt complication by 2%~16.2% patient；It is residual
Remaining shunting complication rate is higher, this will affect the quality of life of patient, therefore reduce occluder for left auricle postoperative residue point
Stream is one of the main target for improving occluder for left auricle clinical value.
The occluder for left auricle of double disk structure is usually made of a sealing and an anchor portion, seals after release
Portion blocks left auricle of heart aperture position, and anchor portion release is in left atrial appendage and has hangnail, plays the role of fixing seal portion.It releases
The sealing for putting rear occluder for left auricle will be fitted tightly over left auricle of heart aperture position, and left auricle of heart oral area is blocked.If sealing
Portion cannot be fitted closely with left auricle of heart mouth, be may cause sealing and be suspended in atrium sinistrum, and left auricle of heart oral area cannot be effectively played
The effect of closure, thereby increases and it is possible to further increase the risk of thrombosis.And cause sealing that cannot effectively be attached to left auricle of heart
One connection type between principal element and sealing and anchor portion of mouth position is related, i.e.,：Between anchor portion and sealing
Cannot be compact link together, the entire length of product is longer, and anchor portion is radially compressed after release, further increases product
Entire length after release, while sealing and anchor portion axial distance can be caused to increase, it cannot be effective after sealing release
It is attached to left auricle of heart oral area, causes residual shunt.
Summary of the invention
The invention proposes a kind of occluder for left auricle, improve the connection type of sealing and anchor portion, can avoid and
Delay occluder for left auricle axial elongated on the whole, is further ensured that sealing attaches and block left auricle of heart mouth.
A kind of occluder for left auricle being cross-linked, including sealing interconnected and anchor portion, the anchor portion tool
The reticular structure for having cutting to be formed, the sealing and anchor portion are respectively provided with the interconnecting piece being made up of shape convergence, sealing
The interconnecting piece of both portion and anchor portion extends towards and the fixation that misplaces.
In the prior art, the interconnecting piece of both sealing and anchor portion is usually and aligns, the end face if being directly connected to
Directly offset, naturally it is also possible to using the connector of transition, this structure will lead to plugging device, and axial length is too long on the whole,
It is unfavorable for sealing.
Sealing and the dislocation of the interconnecting piece of anchor portion are arranged in the present invention, space can be avoided dry during opposite move close to
It relates to, significantly reduces sealing and anchor portion spacing, improve sealing effect.
Optionally, it is structure as a whole between the sealing and anchor portion and respective interconnecting piece, or point being fixed to each other
Body structure.
Sealing can be process by way of weaving or cutting, sealing (or anchor portion) can using rule or not
The reticular structure of rule, using can be as needed in suitable position setting skeleton to improve intensity, skeleton phase when reticular structure
Other parts can be with the increase of sectional area, or at least there is higher intensity, reticular structure can have rule or not
The cell of rule, the preferably cell of diamond shape or near-rhombic can at least be compressed radially, in order to recycling and
Release, reticular structure have apparent longitude and latitude structure, and longitude and latitude intersection can be stationary nodes, more preferably use revocable side
Formula, i.e., can misplace sliding between longitude and latitude, to provide compliance and deformability.
It can be structure as a whole after cutting or braiding between sealing and anchor portion and respective interconnecting piece, Huo Zhelian
Socket part is fixed as independent component by the assembly of the means such as welding.It is preferable that integral structure, easy to process to also ensure
Integral strength.
Optionally, the shape converges to global convergence or local convergence.
Sealing and anchor portion have certain diameter range due to left auricle of heart to be blocked, and interconnecting piece diameter compared with
Carefully, diameter change therebetween can be gradual change or mutation, for example, by using global convergence mode when diameter change position present
Pyramidal structure, and local convergence can be considered as the mutation of diameter, such as be mutated into thinner bar or beam by biggish sectional area.
Optionally, the interconnecting piece on both the sealing and anchor portion is at one, and is connected with each other；Or the sealing
Interconnecting piece in both portion and anchor portion is many places, and is connected with each other correspondingly.
The quantity of interconnecting piece and position when only at one, generally lie in sealing or anchor portion there is no stringent limitation
Middle part.
Optionally, the sealing is connected directly with the interconnecting piece of both anchor portions or is connected by connector.
It being connected directly, i.e. the interconnecting piece of the two contacts with each other, it is fixed to each other by welding, anchor ear, the mutually modes such as winding,
And may be not contact with each other, but be respectively relative to connector and fix by the interconnecting piece of the connected then the two of connector, even
Fitting can be the component that a separate part or multiple components are constituted.
Optionally, the interconnecting piece of both the sealing and anchor portion is along linear extension；Or
The connection of one of them extends along linear extension, the extension of another one along curve；Or
The interconnecting piece of the two extends along curve.
Both sealing and anchor portion are positioned opposite, and the interconnecting piece of the two mutually extends closer and connects, in the mistake of extension
Its path is not limited in journey strictly, in order to simplify structure, preferably the interconnecting piece of both sealing and anchor portion is equal
Along linear extension.
The shape of interconnecting piece itself both may be that simple straight-bar is also likely to be more complicated three-dimensional structure, therefore here
Linear extension be interpreted as overall trend, i.e., there is no detours or bending on the whole for extension process.
As a further preference, the interconnecting piece of both sealing and anchor portion prolongs along occluder for left auricle axis direction
It stretches.
Optionally, the interconnecting piece of both the sealing and anchor portion is at mutually matched position, mutually nested or phase
Mutually deviate.
The interconnecting piece of both sealing and anchor portion is and mutually nested or deviate from each other can be real due to being dislocation arrangement
Continue to extend under the premise of dislocation now, without space interference, deviating from each other herein is not answered for nesting
It is interpreted as being located remotely from each other, such as on the section of vertical occluder for left auricle axis, the interconnecting piece of both sealing and anchor portion
It can be and mutually recline or with certain interval.
Optionally, the end that the interconnecting piece of both the sealing and anchor portion is extended towards and gone past the opponent.
Behind the end that wherein an interconnecting piece is gone past the opponent, also imply that the end of party B is crossed in the end of another interconnecting piece,
Interconnecting piece both in this way at mutually matched position, the projection along vertical occluder for left auricle axis direction be arranged side by side or
It is least partially overlapped.
When sealing is mutually nested with the interconnecting piece of both anchor portions, projection also must be overlapping, deviate from each other
When, projection of shape is related with visual angle, therefore side by side or the equal possibility that partly overlaps, if sealing and anchor portion although dislocation, simultaneously
Other side end is not continued to extend across, then still has and further lifts close to the space of sealing and anchor portion, product structure
It is not compact enough.
Optionally, both sealing and anchor portion mutually recline in the peripheral region of respective interconnecting piece.
The gap of both sealing and anchor portion can be blocked by mutually reclining, and improve sealing effect.
As a further preference, both sealing and anchor portion are mutually pushed against in the peripheral region of respective interconnecting piece.
The mutual abutting of sealing and anchor portion can be regarded as sealing and sealing is at least a part of contacts with each other, and
Due to pushing against power, so that sealing has deformation.
The mutual abutting of sealing and anchor portion can be realized by way of applying pretightning force, it can be more after plugging device release
Good attaching and block left auricle of heart mouth, even if anchor portion or sealing are radially compressed and lengthen, can still keep sealing with
Anchor portion reclines, and guarantees sealing effect.
At least one of choked flow film is equipped in the sealing, sealing is that the wire frame structure that cutting is formed or establishment are formed
Reticular structure.
In conjunction with the prior art, one or more choked flow film is provided in sealing；The periphery of anchor portion can also be into
Row overlay film, such as all or part of overlay film on anchor disk outer surface.
Under the premise of non-specified otherwise, shape and positional relationship described in the present invention are occluder for left auricle
In vivo release expansion after state, can also abbreviation release conditions or swelling state, occluder for left auricle is pressed before release
Contracting is in conveying device, state before can be described as compressive state or discharging.
Optionally, the sealing is seal disc or sealing-plug.
" disk ", " plug " herein is interpreted as rough features of shape, for example, disk be it is flat, outer rim shape substantially conforms to
Physiological make-up feature at left auricle of heart, such as round or other shapes according to actual needs.
Such as plug is with certain thickness column, such as approximate cylinder, rotary table etc., but no matter its periphery or bus
Shape does not limit strictly, on the one hand can refer to the prior art, on the other hand can also according to actual needs, with regard to sealing itself
For shape and non-present invention improves emphasis, and certainly, body of the present invention provides preferred or improved plan.
Preferably, the sealing is seal disc, have the pre-setting state that is not contacted with anchor portion and with anchoring
The abutting state that portion contacts with each other, relative to pre-setting state, the seal disc bottom surface for pushing against state has towards anchor portion side
Deformation.
Preferably, the sealing is seal disc, and there is the pre-setting state not contacted with anchor portion and and anchor
Determine the abutting state that portion contacts with each other；Relative to pre-setting state, the middle part for pushing against the seal disc of state has axially towards anchoring
The deformation of portion's protrusion.
Preferably, the sealing includes trying to get to the heart of a matter and connecting disk backwards to the disk of anchor portion, towards anchor portion
With the waist tried to get to the heart of a matter, wherein described try to get to the heart of a matter as flat or middle part of trying to get to the heart of a matter towards anchor portion side protrusion.
Disk is tried to get to the heart of a matter and waist constitutes cage structure on the whole, and one or more choked flow film can be set in cage type knot
Inside structure, cage structure can be closing or fractional open form in addition to necessary hollow out position, process sealing in braiding
When, there can be a collecting end with disk trying to get to the heart of a matter.
Cage structure is since inside has certain space, even if having certain deformation it is also ensured that sealing effect, especially
For this feature is pushed against with anchor portion suitable for the present invention.
The diameter of cage structure be mainly waist diameter and anchor portion diameter it is substantially suitable, and disk diameter be slightly larger than waist
The diameter in portion is to improve the plugging effect of end.
Preferably, the diameter of waist and anchor portion diameter are basic quite or slightly larger than determining portion's diameter, and in disk and waist
Choked flow film is respectively provided in portion.
Waist has enough outer diameters, and when use can cooperate with left auricle of heart lumen contact with disk, forms dual-seal and imitates
Fruit.
Optionally, the sealing has the pre-setting state that does not contact with anchor portion and contacts with each other with anchor portion
Abutting state, under pre-setting state, the diameter of the disk is greater than the diameter tried to get to the heart of a matter.
Disk described herein or the diameter tried to get to the heart of a matter, the two can be approximately circle, if other shapes, it will be appreciated that be section
The relativeness of long-pending or whole thickness, since the diameter of disk is greater than the diameter tried to get to the heart of a matter, is on the whole circle by taking circle as an example
The top surface of platform shape, upper part is bigger, more down more restrains, the bottom surface of lower part is smaller, in this way when offseting with anchor portion, can comply with
Be bonded with anchor portion.
Optionally, the sealing has the pre-setting state that does not contact with anchor portion and contacts with each other with anchor portion
Abutting state pushes against the sealing of state in waist and/or tries to get to the heart of a matter with deformation relative to pre-setting state.
Pre-setting state refers to that sealing itself is fixed by heat under no assembling or not by external force after processing is completed
The shape that type obtains, due to being pushed against with anchor portion after assembling, and in order to improve or keep this pretightning force, therefore with anchor portion
Deformation is generated after abutting.
Optionally, relative to pre-setting state, the sealing for pushing against state has the deformation radially collapsed in waist.
When sealing and anchor portion are located remotely from each other or when by radial compression, the deformation radially collapsed can offset or delay
Axially extending trend, to guarantee the leakproofness at left auricle of heart opening position.The deformation radially collapsed can be such that waist generates centainly
Taper is also preferably bonded with left auricle of heart to improve sealing effect.
Optionally, relative to pre-setting state, the sealing for pushing against state is being tried to get to the heart of a matter with axially towards anchor portion protrusion
Deformation.
The deformation of similar principle, the axial direction towards anchor portion protrusion can also offset or delay occluder for left auricle whole
On in axial extension.Reclining for sealing and anchor portion is kept as far as possible, guarantees sealing effect.
Optionally, the sealing at least offsets at the outer rim position tried to get to the heart of a matter with anchor portion.The outer rim position tried to get to the heart of a matter and anchor
Determine to can get bigger sealing deformation in the case that portion is mutually against identical pretightning force, more conducively compensates and offset axial prolong
It stretches.
Optionally, the anchor portion is cut by tubing forms；The reticular structure is hexagonal mesh or network knot
The combination of structure or hexagonal mesh and network.
Optionally, the tubing is Nitinol material.
Reticular structure is convenient for radial compression, is exactly that there is no stringent for reticular structure itself convenient for loading and conveying in vivo
Limitation, hexagon, diamond shape or its be combined as preferred form, in addition reticular structure on the whole can also using segmentation shape
Formula, before discharging for state, it is axial it is upper can be divided into multistage according to design feature, for every section, interlocked using longitude and latitude or
Network with obvious unit case form uses axially extending connecting rod between adjacent segment.
Optionally, sealing is bottom towards anchor portion side, and described tubing one end is the interconnecting piece equipped with annular, and should
Interconnecting piece is connected with the bottom of sealing.
Optionally, the seperated knot that the interconnecting piece of anchor portion is structure as a whole or is fixed to each other with the rest part of anchor portion
Structure, i.e., the bottom of the described sealing collect the interconnecting piece that position is then used as sealing.
The bottom of the sealing collects and passes through the interconnecting piece of anchor portion, is equipped on being pierced by part and is limited to anchor portion
Interconnecting piece axial limiting portion.
The interconnecting piece of anchor portion is ring structure, and central area extends through convenient for the part of sealing bottom, is anchored
When the interconnecting piece in portion and the rest part of anchor portion are structure as a whole, the rest part of anchor portion implements cutting, and in end head
The reserved one end in position is not cut, the interconnecting piece of the end position as anchor portion；Furthermore the interconnecting piece of anchor portion is also possible to point
Body structure is fixedly connected using forms such as welding, hook or bindings with the rest part of anchor portion.
Optionally, the anchor portion is by constituting extended segment backwards to sealing extension at itself interconnecting piece, and extended segment is far from close
The side in envelope portion, which turns up to turn back, constitutes back-turning section to the bottom of sealing, and the bottom of the back-turning section and sealing offsets.
Anchor portion generally Eversible structure, the periphery that back-turning section is looped around extended segment forms double-layer structure, in double-layer structure
Portion has certain space, and deformation occurs after can be absorbed and anchor portion being allowed to push against sealing, but does not weaken its anchoring effect
Fruit.
Optionally, the anchor portion is by constituting extended segment backwards to sealing extension at connector, and extended segment is far from linkage section
Side turn up to turn back and constitute back-turning section to the bottom of sealing, the back-turning section folds in the bottom position of sealing
The bottom of mouth formation closing in section, the closing in section and sealing offsets.
Closing in section substantially radially extends inwardly, contacts with the bottom of sealing, is more advantageous to application pretightning force.
Optionally, the closing in section is suspended in the periphery of extended segment or connect with extended segment.
" suspension " there is no connection relationship or is only to be contacted with the periphery of extended segment, each other can be free when deformation
Relative movement, if there is connection, may be a fixed connection or slide, be rotatably assorted, and both constraints are opposite to a certain extent transports
Flowing mode.
Since closing in section is suspended in the periphery of extended segment, it is single layer structure that anchor portion can smooth out with the fingers directly before releasing, in order to fill
It is loaded into sheath and recycling, after anchor portion distal end is detached from sheath when release, has and proximally facing turn over the trend stuck up；With discharging
The progress of journey, distally further towards proximal end turnup；After release, the edge of distal end turnup to proximal end and distal end keeps opening
State.
Optionally, the extended segment is taper, and major part side (i.e. cone bottom side) is far from sealing and opening setting.
Extended segment is horn-like convenient for recycling, and can also be improved the stability of intensity and structure at flaring.
Optionally, the anchor portion contacts with each other with the pre-setting state not pushed against with sealing and with sealing
Abutting state, under pre-setting state, in anchor portion axial direction, the interconnecting piece of anchor portion is than closing in section further from sealing；Relatively
Under pre-setting state, abutting state, in anchor portion axial direction, the interconnecting piece of anchor portion is with respect to closing in section further towards sealing
Portion.
When i.e. sealing and anchor portion are relatively close, closing in section is first contacted with the bottom of sealing, due to the company of anchor portion
Socket part and sealing still have a distance farther out, this section of distance is also that further drawing forms pretightning force there are spaces and can
Energy.
Optionally, under abutting state, in anchor portion axial direction, the interconnecting piece and closing in section flush or ratio of anchor portion close up
Section is further from sealing.
Optionally, reticular structure bifurcated by the interconnecting piece of anchor portion is more support bars, and support bar is through multiple two
It two crosses, constitute the reticular structure after bifurcated again.
Optionally, in the reticular structure, two support bars are 20 ° -70 ° in the intersecting angle of intersection part.
Before release, it is radially in compressive state, each support bar is gathered to center, therefore two support bars are in intersection
The intersecting angle of position refers generally in the released state.
Optionally, the width of shown support bar is 0.18~0.3mm.
Optionally, anchor portion offsets in the intersection part of support bar with sealing.
Intersection part has better intensity and deformation resistance, and anchor portion is offseted by intersection part sealing, can be kept away
Exempt to absorb expected pretightning force in the contact site larger deformation of generation.
Optionally, the support bar mutually crosses 2~6 to end is extended to by the interconnecting piece of anchor portion two-by-two therebetween
It is secondary；The end of the support bar is crossed two-by-two at one.
Mutually cross again two-by-two bifurcated number it is more, grid is denser, otherwise number is more, and grid is more sparse, in conjunction with
The width of support bar and the stock size at left auricle of heart position often cross once, are equivalent to axially and above (discharge preceding state and be used as and join
According to) extend a cell.
End crosses two-by-two can prevent from generating spine structure, avoid stabbing lesions position in release, in crossing for end
Position can polish as rounded structure.
Optionally, the periphery of the interconnecting piece, which is equipped with, reinforces garter spring.
The intensity of interconnecting piece can be further increased by reinforcing garter spring, and reinforcing garter spring can be matched using screw thread, welding or interference
The modes such as close and be fixed on the other periphery of interconnecting piece, reinforce garter spring on axial dimension, can greater than, equal to or be less than interconnecting piece.
Optionally, the cutting part reinforced garter spring and at least extend to anchor portion in the axial direction.
Cutting part is at interconnecting piece, the case where having stress raisers, in order to avoid rising in cutting when assembly
Beginning position generates tearing or unnecessary bending, and the reinforcement garter spring extends in the axial direction and wraps up cutting starting position.Example
It such as can be axially across 2~5mm of starting position of cutting.
Optionally, the periphery of the anchor portion and/or backwards to sealing side be equipped with overlay film.
Overlay film can make anchor portion have plugging action, and overlay film position can be the circle of outer Monday around anchor portion, can also
All to cover in anchor portion backwards to the side of sealing or two positions, the overlay film at certain two positions, which mutually extends, to be drawn close
It can join together, entire anchor portion is wrapped up.
Optionally, the outside of the anchor portion is equipped with hangnail.
Hangnail can stablize the position for keeping occluder for left auricle in left auricle of heart, and in the case where there is overlay film, hangnail is pierced by
Overlay film extends to outside.
Optionally, the hangnail is located at the joint of reticular structure.
Optionally, the hangnail and anchor portion are structure as a whole.
I.e. hangnail is also to cut, and can cut through overdraw at the position for forming hangnail as a part of support bar
Stay, such as cut with "-" type notch in support bar side, or cut with V-notch at the middle part of support bar transverse direction.
Optionally, the bottom of the sealing collects and passes through the interconnecting piece, and the company of being limited to is equipped on being pierced by part
The axial limiting portion of socket part.
Sealing then mutually gathers receipts in the bottom of sealing for weaving the silk of sealing if the reticular structure of braiding
Beam, this, which is collected, is presented as structure feature, also contains corresponding steps when processing, i.e., multi-filament is pooled a bundle.
Sealing cuts the wire frame structure to be formed if tubing, and the end of sealing tubing, which can be used as, collects position.
Optionally, the axial limiting portion is that banding is fixed on the anti-drop head that sealing collects periphery.
Anti-drop head outer diameter is greater than the internal diameter of interconnecting piece, sealing is limited to the state being affixed with anchor portion, and can tie up
Hold necessary pretightning force.
Anti-drop head and reinforce garter spring can for stainless steel, Nitinol or other meet the metal of biocompatibility requirement
Material.
Preferably, the sealing and anchor portion mutually push against.
Preferably, anchor portion has the abutting position to offset with sealing, anchor portion is tubular under compression
Structure, and the inner wall side for pushing against position and being in tubular structure.
Upon discharge, due to the outside turnup of anchor portion, the inner wall side being in originally pushes against position and is in after turnup
It outside and offsets towards sealing, and with sealing.
Under compressive state, need if the outer wall side that abutting position is in tubular structure using increasingly complex turnup side
Otherwise formula is difficult to take into account and obtains big outer diameter in anchor portion to support and be anchored left auricle of heart inner wall.
But under the form using complicated turnup, thus it is possible to vary anchor portion end (distal end of compressive state) extends out when discharging
Trend, can be opposite to improve safety to avoid stabbing left auricle of heart inner wall.
Preferably, the anchor portion and sealing have the use state for directly contacting and pushing against.
Under normal operating condition, anchor portion may be directly to contact and push against, but directly contact and push against simultaneously with sealing
Not exclusive use state, under the action of special physiological construction, or after a period of use, between anchor portion and sealing
It may be located remotely from each other and even generate gap.
Preferably, the sealing is double-layer structure, it is bottom towards anchor portion, is top layer backwards to anchor portion,
Sealing is connected by bottom with anchor portion.
Opposite situation is that anchor portion is connected locally through sealing and with the top of sealing, the present invention in anchor portion with
The bottom of sealing is connected, and is easier to obtain the pre- deformation of sealing when anchor portion and sealing system mutually push against, in other words
Efficiency is obtained with higher deformation.
As further preferred, the inside of the double-layer structure is equipped with one or more layers choked flow film.
It is elongated due to being easier to burst in axially generation pine when sealing uses double-layer structure, the present invention is it is also preferred that applicable
In the sealing of double-layer structure.Either dish type or column can be considered double-layer structure, and built-in choked flow film.
Preferably, the anchor portion and sealing are separate structure.
As further preferred, the anchor portion and sealing mutually push against in assembling process.
Using separate structure, heat treatment shaping respectively, then assembled, and after being pushed against in assembling process
Pre- deformation effects.Although abutting effect can also be obtained according to integral structure, since there is no assembling process therefore to need
It is just obtained after thermal finalization and pushes against effect, therefore requirements at the higher level are proposed to heat setting process, generally required to anchor portion and sealing
Portion is heat-treated respectively, improves processing difficulty.
It is continuously distributed in the circumferential in order to obtain preferable support and anchoring effect, the anchor portion.
Although net or rod-like structure have gap in the axial direction, should continuously divide in the axial direction in overall structure and distribution
Cloth avoids only providing support by circumferential part to strive for distribution of force more evenly and stablize support.
Preferably, outer edge of the position that abuts each other of anchor portion and sealing adjacent to sealing.
Preferably, the position that anchor portion and sealing abut each other is also adjacent to the outer edge of anchor portion.
Outer edge position, which offsets, more easily obtains the convergence of axial deformation or radial direction, improves deformation under same stress
Amount.
Preferably, the sealing and anchor portion are assembled after completing thermal finalization, sealing and anchor portion when assembly
First state with initial contact；
Connecting portion between sealing and anchor portion also has the second state after being axially towards one another movement preset distance.
First state sealing portion and is just contacted with anchor portion, since sealing and anchor portion have all completed heat
Sizing, so if the two moves toward one another one of them axially further can generate deformation and keep deformation in the second condition
Bring stress.
Preferably, the connecting portion between the sealing and anchor portion both is located at radial middle part, first
Peripheral region under state between the sealing and anchor portion in connecting portion is in contact.
Above-mentioned stress is also the source of the pretightning force, if before without thermal finalization, but thermal finalization again after assembling, that
Stress can disappear when heat treatment, can not generate required pretightning force.
Therefore it is emphasized that under the second state, the sealing and the relative position that anchor portion is after being assembled
Relationship is no longer heat-treated after the second state.
Since anchor portion has better rigidity, the generation of general stress is mainly derived from the deformation of sealing.
Preferably, relative to first state, the position that is connect on sealing with anchor portion in the second state more towards
It moves close to anchor portion side.
When being transferred to the second state, connecting portion of the sealing between anchor portion is axially towards one another at a distance from movement, is influenced
The size of stress, therefore need to be expressed in a manner of adapting to and accordingly controlled in assembly.
Preferably, the expression way of the preset distance is：
The axial force of connecting portion between sealing and anchor portion；Or
The pressure of contact site between sealing and anchor portion；Or
The deformation quantity at the position being connect on sealing with anchor portion.
The deformation quantity is the Axial changes amount or sealing predetermined position and sealing axis of sealing predetermined position
Angle.
The sealing predetermined position is the position that deformation occurs when first state changes to the second state, for the ease of table
It reaches and measures, can choose the relatively large position of deformation quantity.Such as the sealing predetermined position is to seal under first state
The position that portion is contacted with anchor portion
By detecting the variable quantity of the expression way of preset distance when assembly, stress intensity obtained can be corresponded to.
If without the presence of the stress, even if sealing and anchor portion have localized contact when assembly, but in use process
It is when the axial whole elongation of occluder for left auricle, i.e., inherent between sealing and anchor portion when sealing and anchor portion are located remotely from each other
Restoring force it is smaller, axial whole elongate only is overcome by the elasticity of respective material.
In the present invention, by way of passing through first thermal finalization, rear assembly and retaining axial stress when assembling, it can make subsequent
With preferably overcoming the axial entirety of occluder for left auricle to elongate in the process, pass through the elasticity of sealing and anchor portion material and preload
The superposition of power improves restoring force, ensure that the plugging effect of long-time service.
Accordingly the present invention also provides the assembly method of the occluder for left auricle being cross-linked described in one kind, sealing with
Anchor portion is assembled after completing thermal finalization, and sealing and anchor portion are closer and when initially contacting mutually the first shape when assembly
State；On the basis of first state, the connecting portion between sealing and anchor portion reaches after being axially towards one another movement preset distance
Second state；
Connecting portion between sealing and anchor portion is fixed to each other, so that connecting portion is maintained at the second state and completes dress
Match.
Since mutual localized contact, first state to the second state turn for first state sealing portion and anchor portion
When change, sealing as a whole may be with the axial position between anchor portion there is no changing, and only local deformation generates
Stress.
Occluder for left auricle of the present invention is transported to the heart by delivery sheath by way of percutaneous puncture
Left atrial appendage occlusion is formed thrombus to prevent patients with atrial fibrillation in left auricle of heart and then leads to the wind of apoplexy by the position of dirty left auricle of heart
Danger.
The present invention realizes being cross-linked for sealing and anchor portion by improved connection type, can allow sealing and left
The even closer and closure left auricle of heart opening that auricle attaches, with the incidence of leakage and residual shunt in reduction.
Detailed description of the invention
Fig. 1 is the schematic diagram of the occluder for left auricle in embodiment one；
Fig. 2 is the schematic diagram in embodiment one after sealing thermal finalization；
Fig. 3 is the schematic diagram in embodiment one after anchor portion thermal finalization；
Fig. 4 a is the schematic diagram of anchor portion and sealing connection procedure (anchor portion side) in embodiment one；
Fig. 4 b is part A enlarged drawing in Fig. 4 a；
Fig. 5 is the schematic diagram of anchor portion and sealing connection procedure (sealing side) in embodiment one；
Fig. 6 starts the schematic diagram docked with sealing for anchor portion in embodiment one；
Fig. 7 a is that anchor portion connect the schematic diagram completed with sealing in embodiment one；
Fig. 7 b is the connection schematic diagram of sealing and anchor portion in the prior art；
Omit schematic diagram in the part that Fig. 7 c is Fig. 7 a；
Fig. 8 is that occluder for left auricle is put into the schematic diagram blocked in left auricle of heart in embodiment one；
Fig. 9 a is the schematic diagram of the occluder for left auricle in embodiment two；
Fig. 9 b is part A enlarged drawing in Fig. 9 a；
Figure 10 is the schematic diagram of anchor portion and sealing connection procedure in embodiment two；
Figure 11 a is the schematic diagram of the occluder for left auricle in embodiment three；
Figure 11 b is part A enlarged drawing in Figure 11 a；
Figure 12 a is the schematic diagram of anchor portion and sealing connection procedure in embodiment three；
Figure 12 b is part A enlarged drawing in Figure 12 a；
Figure 13 is the schematic diagram of anchor portion and sealing connection procedure in embodiment three；
Figure 14 is the schematic diagram of the occluder for left auricle in example IV.
Figure 15 a is the schematic diagram of the occluder for left auricle in embodiment five；
Figure 15 b is the side view of sealing in embodiment five；
Figure 15 c is the perspective view of sealing in embodiment five；
Figure 16 is the schematic diagram of the occluder for left auricle in embodiment six；
Figure 17 a~Figure 17 c is that anchor portion discharges process schematic in embodiment seven, and sealing is shown with state after discharging in figure
Meaning；
Figure 18~Figure 20 is the schematic diagram of the sealing of different shapes of trying to get to the heart of a matter in embodiment seven；
Figure 21~Figure 25 is the control schematic diagram of seven mid-game bottom of embodiment deformation front and back；
Figure 26~Figure 28 tries to get to the heart of a matter for another shape in embodiment seven deforms the control schematic diagram of front and back；
Figure 29~Figure 30 is the control schematic diagram of eight mid-game bottom of embodiment deformation front and back；
Figure 31~Figure 40 is the assembly front and back schematic diagram of different connection types in embodiment nine.
Specific embodiment
Embodiment one：
As shown in Figure 1, the occluder for left auricle 1000 of the embodiment of the present invention one includes 1100 He of sealing interconnected
Anchor portion 1200.Sealing 1100 is woven using titanium-nickel wire, and anchor portion 1200 cuts to be formed using tubing.
Sealing 1100 includes disk 1110, waist 1120 and 1170 compositions of trying to get to the heart of a matter, and has bolt head 1130, disk in disk end
Be sewed with 1 layer of PET choked flow film 1140 in face, in the middle part of waist in be sewed with 1 layer of choked flow film 1150, try to get to the heart of a matter in be sewed with 1 layer of choked flow film
1160。
Netted cylindrical 1220, the outer layer end bending part by the netted taper 1210 of internal layer, outer layer of anchor portion 1200
1230, arc transition part 1240 and outer layer netted cylinder of the netted taper 1210 of internal layer with outer layer netted cylindrical 1220
The arc transition part 1250 of shape 1220 and end bending part 1230 forms, in outer layer netted cylindrical 1220 outer surface week
To there is equally distributed hangnail 1270.
Wherein the netted taper 1210 of internal layer is equivalent to extended segment；Outer layer netted cylindrical 1220 is equivalent to back-turning section；Outer layer
End bending part 1230 is equivalent to closing in section.
Sealing, which is tried to get to the heart of a matter, distally to link together with anchor portion inner layer net tapered proximal end, which can be by just covering
The mode of fastening or laser welding links together.
Before proceeding, sealing is crossed at mold high warm using cylindrical braiding NiTi Netcom for sealing and anchor portion
Reason is formed.Sealing 1100 after visible 1000 heat treatment shaping of plugging device of Fig. 2 has a distal end titanium-nickel wire 1171 and collects
Processing, is equivalent to the interconnecting piece of sealing.
Anchor portion in cutting, do not cut by reserved one section of end, and after high-temperature heat treatment sizing, reserved position is used as ring
The distal end titanium-nickel wire 1171 of sealing 1100 is passed through the interconnecting piece of annular when installation, after being pierced by by the interconnecting piece of the anchor portion of shape
Redundance is cut off mutually axially to limit in interconnecting piece of the end by way of welding or installing steel bushing with annular.
In other mode, anchor portion the sizing of mold high-temperature heat treatment is also crossed using cylindrical braiding NiTi Netcom and
At referring to Fig. 3, the netted taper 1210 of 1200 internal layer of anchor portion has a proximal end titanium-nickel wire 1261 and collects processing, and when installation will be close
The distal end titanium-nickel wire 1171 in envelope portion 1100 and the proximal end titanium-nickel wire 1261 of anchor portion 1200 interlock by the way that connector is mutually interspersed
Connection.
Anchor portion either cutting mode or weaving manner, features of shape and working principle it is similar, it is different
When mainly using weaving manner, the staggered position of longitude and latitude is can be movable, i.e., is only that phase interconnection is set and connect between longitude and latitude
Touching, is not fixed to each other, and the staggered position of longitude and latitude is fixed when cutting mode, because being before being cut integrated knot
Structure.
Certainly it can also use and make layered shaping at the staggered position of longitude and latitude, i.e., it is the tube wall of tubing is staggered in longitude and latitude
Position cutting be two layers, can enable longitude and latitude relatively activity and separation, with establishment structure it is similar.
Fig. 4 a~Fig. 7 c is the sealing 1100 and anchor portion 1200 of occluder for left auricle 1000 in the embodiment of the present invention one
A kind of connection type.
Such as anchor portion uses weaving manner, the proximal end titanium-nickel wire 1261 of anchor portion is convergent on 1262 (phase of an outer layer steel bushing
When in outer ring) and an internal layer steel bushing 1263 (being equivalent to inner ring) between, in figure it is visible i.e. exist for weaving the titanium-nickel wire of anchor portion
The proximal end of extended segment collects, and is connected with the ectonexine steel bushing as connector.In Fig. 4 a as can be seen that as the interior of connector
Outer layer steel bushing, than closing in section further from sealing, the anchor portion of turnup structure substantially bowl (or nest) shape, connector is located at bowl
It is interior to sink to below the rim of a bowl.
Then ectonexine steel bushing and the proximal end titanium-nickel wire 1261 between it are fixed on one by welding or compressing mode
It rises, internal layer steel bushing 1263 is a hollow structure, then by cutting or laser treatment mode will be other than 1262 proximal end of outer layer steel bushing
Titanium-nickel wire remove.
Such as Fig. 5 and Fig. 6, the distal end titanium-nickel wire 1171 of sealing passes through internal layer steel bushing 1263 after the middle part tried to get to the heart of a matter collects,
Certain pulling force can be applied by sealing 1100 and the compact connection of anchor portion 1200, form certain pretightning force, and pass through this
Pretightning force makes the stretching waist of sealing at the structure of a taper, while can reduce the whole height of occluder for left auricle.
In other embodiments, the distal end titanium-nickel wire 1171 of sealing passes through internal layer steel bushing after the middle part tried to get to the heart of a matter collects
1263, it, can be by sealing 1100 due to distal end titanium-nickel wire 1171 and the interlaced arrangement of internal layer steel bushing 1263 spatially
With anchor portion 1200 as close as possible to reduce occluder for left auricle axial dimension, not stringent limitation needs to push against.
In other embodiments, the distal end titanium-nickel wire 1171 of sealing passes through internal layer steel bushing after the middle part tried to get to the heart of a matter collects
1263, it, can be by sealing 1100 due to distal end titanium-nickel wire 1171 and the interlaced arrangement of internal layer steel bushing 1263 spatially
With anchor portion 1200 as close as possible to until contacting to reduce occluder for left auricle axial dimension, sealing 1100 and anchor portion
1200, which contact with each other but do not limit strictly, does not need to push against.
Such as anchor portion uses cutting mode, proximal end titanium-nickel wire 1261, outer layer steel bushing 1262,1263 three's group of internal layer steel bushing
The reserved not cutting part in end, i.e., annular when the centre formed after dress can be considered as tubing cutting with the structure of axial passage
Interconnecting piece.
The distal end titanium-nickel wire 1171 of sealing passes through the interconnecting piece of annular after the middle part tried to get to the heart of a matter collects, then can apply certain
Pulling force by sealing 1100 and the compact connection of anchor portion 1200, form certain pretightning force.
Sealing structural form as shown in Figure 6；The distal end titanium-nickel wire 1171 of sealing (is equivalent to anti-by steel bushing 1172
De- head) it is fixed together, steel bushing 1172 should be slided and be fixed after pushing against the distal end of internal layer steel bushing 1263 with distal end titanium-nickel wire 1171.
This 1172 outer diameter of steel bushing is greater than the internal diameter of internal layer steel bushing 1263, prevents distal end titanium-nickel wire 1171 from deviating from internal layer steel bushing 1263.
Such as anchor portion uses cutting mode, then (is equivalent to the distal end titanium-nickel wire 1171 of sealing by steel bushing 1172
Anti-drop head) it is fixed together, steel bushing 1172 should slide and push against the interconnecting piece distal end of anchor portion, prevent distal end titanium-nickel wire 1171 de-
Annular interconnecting piece out.
The extra distal end titanium-nickel wire 1171 in sealing distal end is cut later or laser mode is disposed.It is of the present invention
Steel bushing material can for stainless steel, Nitinol or other meet the metal material of biocompatibility requirement, the present embodiment is selected
Stainless steel material.
In assembling process, when sealing 1100 and anchor portion 1200 are mutually moved close to, first state can be considered when just contacting,
With the axial further drawing of distal end titanium-nickel wire 1171, side meeting and anchor portion of the sealing 1100 towards anchor portion 1200
1200 gradually push against generation stress, that is, pretightning force, reach the second state after the axial drawing preset distance of distal end titanium-nickel wire 1171, this
When pass through steel bushing 1172 again sealing 1100 and anchor portion 1200 be maintained at the second state, that is, keep the presence of stress.
Axial drawing preset distance can be measured directly, can also be according to sealing 1100 towards the one of anchor portion 1200
Side be try to get to the heart of a matter 1170 change in shape expression obtain, can also directly measure the pulling force or sealing 1100 of distal end titanium-nickel wire 1171
Pulling force between anchor portion 1200.
The shape that 1170 change in shape of trying to get to the heart of a matter both had been referred to oneself in first state, can also be referring under different conditions
With the angle of 1100 axis of waist 1120 or sealing.
Comparison diagram 6 and Fig. 7 a can obviously learn, (on the basis of Fig. 6 sealing 1100 and anchor portion 1200 under first state
It further closer contacts, but due to being just to have contacted, the shape of sealing 1100 is not changed, therefore can refer to Fig. 6
Shape.) try to get to the heart of a matter it is 1170 substantially vertical with waist 1120, and under the second state of Fig. 7 a, try to get to the heart of a matter 1170 with the angle of waist 1120
Increase, 1170 radial middle parts of trying to get to the heart of a matter can also further be expressed towards 1200 side of anchor portion protrusion, therefore by variable angle
The preset distance axially pulled with control distal end titanium-nickel wire 1171.
After sealing 1100 is connect with anchor portion 1200, by way of suture, in occluder for left auricle sealing disk
Inseam unifies layer PET choked flow film 1140, sealing waist centre and suture 1 layer of PET choked flow film, 1150, the 1 layers of PET respectively that try to get to the heart of a matter
Choked flow film 1160, as shown in Figure 1.
Sealing 1100 is on the whole the cage structure with certain inner space, and under pre-setting state, waist is substantially
To be cylindric, comparison diagram 2 and Fig. 7 a can be seen that pan bottom position after assembling and mutually push against with closing in section, and waist distal side is radial
It collapses deformation and has certain taper, form substantially inverted round stage structure, moreover under the action of pretightning force, middle part of trying to get to the heart of a matter
Towards anchor portion side protrusion.
Referring to Fig. 7 b, sealing 1100 has interconnecting piece 1180 in the prior art, and anchor portion 1200 has interconnecting piece
1280, the interconnecting piece of 1200 the two of sealing 1100 and anchor portion is extended towards and is aligned, and is extended to after contacting with each other and is led to
The modes such as welding or circumferential band are crossed to be fixed.
There is larger gap between visible sealing 1100 and anchor portion 1200 in figure, sealing effect has much room for improvement.
In the present embodiment, sealing 1100 and the respective position that collects of anchor portion 1200 are used as interconnecting piece or anchor portion
The non-cut portion of 1200 ends is as interconnecting piece.For ease of operation, 1200 end of anchor portion can also carry out cutting raising
Compliance, it is identical when connection type is with braiding after cutting, i.e., first end is gripped using inside and outside steel bushing.
Referring to Fig. 7 c, after completing assembly, the interconnecting piece of anchor portion 1200 is fixed on outer layer steel bushing 1262 and internal layer steel bushing
Between 1263, and the interconnecting piece of sealing 1100 is fixed after passing through internal layer steel bushing 1263 by steel bushing 1172, and steel bushing 1172 pushes against interior
The distal end side of layer steel bushing 1263, the interconnecting piece that can be seen that sealing 1100 from the connection type are in middle section, are anchored
The interconnecting piece in portion 1200 is in its peripheral region, and the interconnecting piece of the two is inside and outside staggeredly, and crosses mutual end position.
It is axially the interconnecting piece and sealing of anchor portion 1200 in Fig. 7 c if A direction projection along occluder for left auricle
1100 interconnecting piece is mutually nested, and respective extension path is straight line, i.e., axially extending along occluder for left auricle, due to being wrong
Position arrangement does not have the interference on space in respective extend, further as far as possible sealing 1100 and anchor portion 1200 away from
From until mutually mutually being pushed against in the interconnecting piece peripheral region of the two.
Along vertical occluder for left auricle axis direction, that is, Fig. 7 c if B direction projection, the interconnecting piece of anchor portion 1200 with
The interconnecting piece of sealing 1100 is overlapped, and the interconnecting piece of sealing 1100 is in the projected area of the interconnecting piece of anchor portion 1200
In domain.
In the present embodiment, sealing 1100 and anchor portion 1200 and respective interconnecting piece are all integral structures, moreover,
Separate form can also be used, i.e., what is do not extended towards collects, but the two is in an opposite middle side part all companies of being fixed with
The connecting rod of extension bar, one of them is hollow structure, and the connecting rod of another one extends there through, and inside and outside interlock also may be implemented in this way
Be fixedly connected.
As shown in figure 8, the present embodiment left auricle of heart envelope device 1000 is transported in left auricle of heart by percutaneous catheter transportation system
Afterwards, which is anchored in left auricle of heart, and the connection type of anchor portion and sealing to form one between two parts
The structure of pretightning force, 1120 taper of occluder for left auricle waist can be attached preferably with the aperture position of left auricle of heart, be pre-tightened
It is even closer that power can allow sealing disk 1110 to attach with left auricle of heart, so that 3 layers of overlay film effectively stop blood flow to flow into a left side
In auricle, to reduce the interior incidence leaked.
Embodiment two：
The occluder for left auricle 2000 of the embodiment of the present invention two is made of sealing 2100 and anchor portion 2200, sealing with
Planform after anchor portion thermal finalization is the same as example 1.It is the company of anchor portion and sealing with the difference of embodiment one
Connect mode difference.It is described in detail by taking weaving manner as an example below.
As shown in figures 9 a and 9b.
Sealing 2100 and anchor portion in the embodiment of the present invention two after 2000 heat treatment shaping of occluder for left auricle
2200, wherein sealing 2100 has a distal end titanium-nickel wire to collect, and anchor portion 2200 has a proximal end titanium-nickel wire to collect.
As shown in Figure 10, the distal end titanium-nickel wire 2171 of sealing and the proximal end titanium-nickel wire of anchor portion in the present embodiment
2261 respectively collect after it is (opposite) across a steel bushing 2272 (being equivalent to connector ontology) from opposite direction.
Direction shown in arrow applies pulling force to two beam titanium-nickel wires respectively along Figure 10, makes seal disc 2100 and anchor portion
2200 compact connections form certain pretightning force, and make the waist 2120 of sealing be drawn into one by this pretightning force
The structure of taper；Then such as Fig. 9 b, the proximal end titanium-nickel wire 2261 of anchor portion can be passed through compression or welding side through steel bushing 2263
Formula is fixed together.
By the distal end titanium-nickel wire 2171 of sealing after steel bushing 2172 is fixed together by compression or welding manner, then
2272 two sides of steel bushing are stuck in, and extra titanium-nickel wire is cut or is disposed by way of laser treatment.
When anchor disk uses cutting mode, the proximal end of anchor portion 2200 can not cut through out after steel bushing 2272 itself
Flange is limited in 2272 side of steel bushing, can also omit steel bushing 2263 in this way.
In order to improve flexibility convenient for operation, the proximal end of anchor portion can also be cut into several Nitinol slices or nickel
Titanium alloy reticulated, and processing is collected accordingly.The proximal end of anchor portion 2200 is formed directly into steel bushing 2272, and applying pulling force makes seal disc
2100 and the compact connection of anchor portion 2200, the proximal end of anchor portion is through steel bushing 2263 by compressing or welding manner is fixed on one
It rises, is stuck in 2272 side of steel bushing.
Referring to Fig. 9 b, in the present embodiment sealing 2100 and anchor portion 2200 also using with embodiment it is a kind of as mode,
With integral structure and the interconnecting piece that extends towards, the interconnecting pieces that both difference is are that the mode deviated from each other is interlocked, to scheme
For middle orientation, one keeps left, and another one is kept right.
It equally can be mutual as far as possible by sealing 2100 and anchor portion 2200 to avoid space interference when extending towards
It furthers.
Embodiment three：
Occluder for left auricle 3000 is made of sealing 3100 and anchor portion 3200 in the embodiment of the present invention three, sealing
3100 is identical as embodiment one, embodiment two as the planform after 3200 thermal finalization of anchor portion.With embodiment one, embodiment
Two difference is that anchor portion is different from the connection type of sealing.It is described in detail by taking weaving manner as an example below.
As shown in Figure 11 a and Figure 11 b.
Sealing 3100 and anchor portion in the embodiment of the present invention three after 3000 heat treatment shaping of occluder for left auricle
3200, wherein sealing 3100 has a distal end titanium-nickel wire to collect, and anchor portion 3200 has a proximal end titanium-nickel wire to collect.Figure 12 a~figure
13 be the sealing 3100 of occluder for left auricle 3000 in the embodiment of the present invention three and another connection type of anchor portion 3200.
In the present embodiment in occluder for left auricle 3000, the distal end titanium-nickel wire 3171 of sealing 3100 collects and passes through outer layer
Between steel bushing 3172 and internal layer steel bushing 3173, then by welding or compressing mode for outer layer steel bushing 3172 and internal layer steel bushing
3173 titanium-nickel wire is fixed together, internal layer steel bushing 3173 be a hollow structure, then by cut or laser treatment mode will
Titanium-nickel wire other than distal end removes.
The proximal end titanium-nickel wire 3261 of anchor portion collects and passes through the internal layer steel bushing 3173 of sealing distal end, penetrates sealing
Net is intermediate, can apply certain pulling force and sealing and the compact connection of anchor portion are formed certain pretightning force, and is pre- by this
Clamp force makes the stretching waist of sealing at the structure of a taper；Then the proximal end NiTi tow of anchor portion is passed through into steel bushing
3162 are fixed together, this 3162 outer diameter of steel bushing is greater than the internal diameter of sealing internal layer steel bushing 3173, and anchor portion proximal end is extra
Titanium-nickel wire cut or laser treatment is fallen.
When anchor disk uses cutting mode, the proximal end of anchor portion 2200 can not do cutting and be pierced by internal layer steel bushing 3173
Itself flange is limited in 3173 side of internal layer steel bushing afterwards, can also omit steel bushing 3162 in this way.In order to improve flexibility convenient for behaviour
Make, the proximal end of anchor portion can also be cut into several Nitinol slices or Nitinol net, and collect processing, anchor accordingly
The proximal end for determining portion 2200 is formed directly into internal layer steel bushing 3173, then passes through the fixed limit of steel bushing 3162.
Example IV：
The difference of the present embodiment and embodiment one is the shape of sealing 4100, as shown in figure 14.
Sealing 4100 is flat plate-like in the present embodiment, i.e., seal disc, seal disc are double-layer structure, inside setting resistance
Film is flowed, under the action of pretightning force, the middle part of seal disc bottom surface is raised towards anchor portion side.
Anchor portion is the diamondoid unit cells structure made of tubing is cut, and the proximal end of anchor portion is the non-cutting part of tubing
Point, and the interconnecting piece as annular, interconnecting piece is externally provided with reinforcement garter spring, reinforces a part of garter spring for anchor portion adjacent to interconnecting piece
Cutting initiation region package, to improve local strength.
When assembling the distal end titanium-nickel wire of sealing 4100 collect and pass through annular interconnecting piece, be pierced by part be provided with it is anti-
De- head, anti-drop head outer diameter are greater than the internal diameter of interconnecting piece, the end that can be collected titanium-nickel wire by way of welding and banding
It is fixed.
Embodiment five：
As shown in Figure 15 a~15c, the occluder for left auricle of the embodiment of the present invention five includes sealing 5100 interconnected
With anchor portion 5200.Sealing 5100 is woven using titanium-nickel wire, and anchor portion 5200 is the wire frame made of tubing is cut
Structure.
The assembly method of sealing and sealing and anchor portion is by the way of embodiment one in the present embodiment, and and anchor
Determine portion mutually to push against, and the main distinction uses cutting mode in anchor portion.
Sealing 5100 includes disk 5110, waist 5120 and 5170 compositions of trying to get to the heart of a matter, and has bolt head 5130, disk in disk end
Be sewed with 1 layer of PET choked flow film 5140 in face, in the middle part of waist in be sewed with 1 layer of choked flow film 5150, try to get to the heart of a matter in be sewed with 1 layer of choked flow film
5160。
Anchor portion netted cylindrical 5220, outer layer end bending part 5230, internal layer by the netted taper 5210 of internal layer, outer layer
Netted taper 5210 and the arc transition part 5240 of outer layer netted cylindrical 5220 and outer layer netted cylindrical 5220 and end
The arc transition part 5250 of portion's bending part 5230 forms, and is circumferentially uniformly distributed in netted cylindrical 5220 outer surface of outer layer
Hangnail 5270.
Wherein the netted taper 5210 of internal layer is equivalent to extended segment；Outer layer netted cylindrical 5220 is equivalent to back-turning section；Outer layer
End bending part 5230 is equivalent to closing in section.
Sealing, which is tried to get to the heart of a matter, distally to link together with anchor portion inner layer net tapered proximal end.
Sealing 5100 has a distal end titanium-nickel wire 5171 and collects processing, and the proximal end of anchor portion is the non-cutting part of tubing
Point, and the interconnecting piece 5260 as annular, interconnecting piece 5260, which is externally provided with, reinforces garter spring 5280, reinforces a part of garter spring 5280
Anchor portion is wrapped up adjacent to the cutting initiation region of interconnecting piece 5260, to improve local strength.
When assembling, distal end titanium-nickel wire 5171 passes through interconnecting piece 5260, is provided with anti-drop head 5172, anti-drop head being pierced by part
5172 outer diameters are greater than the internal diameter of interconnecting piece 5260, can be by way of welding and banding by the end of distal end titanium-nickel wire 5171
Portion is fixed.
Anti-drop head 5172 can limit relative to interconnecting piece 5260 and tense sealing 5100, by sealing 5100 and anchor portion
5200 compact connections form certain pretightning force, and make the stretching waist of sealing at a taper by this pretightning force
Structure, while the whole height of occluder for left auricle can be reduced.
Anchor portion is reticular structure, have be diamondoid unit cells structure, by interconnecting piece ing bifurcated be more support bars, each
Stay width is 0.18~0.3mm.
Such as wherein a support bar 51, support bar 51 extend a distance into rear bifurcated as 511 He of support bar by interconnecting piece
After support bar 512, support bar 511 and support bar 512 respectively extend, and cross with the support bar on adjacent position, such as support
Item 511 and support bar 513 cross, and are equipped with hangnail 5270 in intersection part.Corresponding support bar is at 5270 position first of hangnail
It is secondary cross after again bifurcated respectively extend, and cross for second in end 5290.Support bar 511 and support bar 513 are in intersection part
Intersecting angle be 20 ° -70 °.
Embodiment six：
As shown in figure 16, the difference of the present embodiment and embodiment five is the shape of sealing 6100, as shown in figure 16, this
Sealing 6100 is flat plate-like in embodiment, i.e., seal disc, seal disc are double-layer structure, inside setting choked flow film, pre-
Under the action of clamp force, the middle part of seal disc bottom surface is towards 6200 side of anchor portion protrusion, to form pretightning force.
Embodiment seven：
The present embodiment emphasis illustrate anchor portion release and in assembling process sealing shape variation, anchor portion with
And sealing specific structure can combine unless otherwise specified at least one of other embodiments.
Referring to Figure 17 a~Figure 17 c, occluder for left auricle includes sealing 5100 and anchor interconnected in the present embodiment
Determine portion 5200, anchor portion 5200 is compressed in sheath to be walked in vivo into lesions position, compressive state before releasing
Lower anchor portion 5200 is tubular, and position A is in cylindrical inner wall, as (turnup direction can be found in arrow to the release of 5200 turnup of anchor portion
Head instruction direction), position A is gradually turned up by cylindrical inner wall, is finally offseted with the position of trying to get to the heart of a matter of sealing 5100.
Referring to Figure 18~Figure 20, sealing 1100 includes disk, waist and tries to get to the heart of a matter 5110, and 5110 central area of trying to get to the heart of a matter is received
Beam forms distal end titanium-nickel wire 5120, and distal end titanium-nickel wire 5120 passes through the connecting portion 5210 of anchor portion (for example, by using shapes such as steel bushings
Formula).
In various embodiments, try to get to the heart of a matter 5110 central region can backwards to anchor portion protrusion, such as Figure 18；It tries to get to the heart of a matter
5110 central region can be flat, such as Figure 19；Try to get to the heart of a matter 5110 central region can also towards anchor portion protrusion, such as Figure 20.
Above it is to try to get to the heart of a matter 5110 not assembling completion, i.e., not yet applies features of shape when pretightning force, apply pretightning force
Afterwards, 5110 central region of trying to get to the heart of a matter has different degrees of deformation, generally further draws close towards anchor portion.
1~Figure 25 referring to fig. 2, by taking one of which tries to get to the heart of a matter shape as an example, sealing is respectively processed and is heat-treated with anchor portion
Start to assemble after sizing, the connecting portion 5210 that distal end titanium-nickel wire 5120 passes through anchor portion is first made into sealing and anchor portion edge
It is axial close to each other.
Such as Figure 22, just contact still without applying pretightning force when be first state, try to get to the heart of a matter at this time 5110 central region C tool
Have the tendency that then distal end titanium-nickel wire 5120 is pulled downward on along Figure 23 arrow direction, and the company of anchor portion backwards to anchor portion protrusion
Socket part position 5210 then moves upwards in the direction of the arrow relatively, and central region C stress and deformation is until reach scheduled deformation or preload
Force request recycles 5130 stationary remote titanium-nickel wire 5120 of anti-drop head, at this time as the second state, such as Figure 24, central region C by
Power deformation is in flat state substantially.
In order to control assembling process, the variation of angle B or the axial direction of central region C can be monitored when applying pretightning force
Variable quantity H, central region C stress and deformation can more obviously be embodied by Figure 25 comparison, and dotted line expresses middle part under first state
The position of region C.
6~Figure 28 referring to fig. 2, in another embodiment, sealing have just been contacted still with anchor portion without applying pretightning force
When be first state, the 5110 central region C of trying to get to the heart of a matter at this time has trend backwards to anchor portion protrusion, distal end titanium-nickel wire when assembly
It pulls downward on, and the connecting portion of anchor portion then relative upward movement, central region C stress and deformation is until reach scheduled deformation
Or force request is pre-tightened, recycle anti-drop head stationary remote titanium-nickel wire, as the second state at this time, when central region C stress and deformation
The waist of sealing is radially converged along Figure 27 arrow direction, is on the whole in the second condition inverted cone shape together with pan bottom, is passed through
Figure 28 comparison can more obviously embody, and dotted line expresses the position of waist and central region C under first state.
Embodiment eight：
9 and Figure 30 referring to fig. 2, occluder for left auricle includes sealing 6100 and anchor portion 6200, sealing in the present embodiment
Portion 6100 is in the first state that inverted cone shape tries to get to the heart of a matter 6110 towards the side in anchor portion, and 6110 central areas of trying to get to the heart of a matter collect to be formed
Distal end titanium-nickel wire 6120, distal end titanium-nickel wire 6120 pass through the connecting portion 6210 of anchor portion 6200 (for example, by using shapes such as steel bushings
Formula).
Under the second state after assembly, try to get to the heart of a matter 6110 middle part further move close to 6210 taper of connecting portion increase, distal end
Titanium-nickel wire 6120 locks axial position by anti-drop head 6130.
Embodiment nine：
The present embodiment emphasis illustrates anchor portion and the different connection type of sealing, and anchor portion and sealing are specific
Structure can combine unless otherwise specified at least one of other embodiments.
In the present embodiment attached drawing, occluder for left auricle includes sealing 7100 interconnected and anchor portion 7200, close
Envelope portion 7100 includes disk, waist and tries to get to the heart of a matter 7110.
Figure 31, Tu32Zhong, the 7110 central area shape of trying to get to the heart of a matter restrain to form interconnecting piece, i.e., central area collect to be formed it is remote
Hold titanium-nickel wire 7120, shape restrains to form interconnecting piece on the whole at the middle part of anchor portion, end by connector 7210 (such as
Using steel bushing) it is fixed, distal end titanium-nickel wire 7120 passes through the hollow part of the connector 7210 of anchor portion and opposite tenses when assembly
Pretightning force is formed, anchor portion and sealing mutually push against the central region deformation at hub disk bottom further towards anchor portion protrusion, most
(for example, by using the stirrup) stationary remote of anti-drop head 7130 titanium-nickel wire 7120 is utilized afterwards, then cuts off the excess portion of distal end titanium-nickel wire 7120
Divide and completes assembly.
In other embodiment, referring to Figure 33, Figure 34, the 7110 central area shape of trying to get to the heart of a matter restrains to form interconnecting piece,
I.e. central area collects to form distal end titanium-nickel wire 7120, and shape restrains on the whole at the middle part of anchor portion, that is, collects to form proximal end nickel
Titanium silk 7220, using band, there are two the connectors 7210 in the channel being arranged side by side, so that distal end titanium-nickel wire 7120 and proximal end NiTi
Silk 7220 is in opposite directions through corresponding channel and opposite tense forms pretightning force, after anchor portion and sealing mutually push against
The central region deformation tried to get to the heart of a matter is finally fixed remote using anti-drop head 7130 (for example, by using stirrup) further towards anchor portion protrusion
Titanium-nickel wire 7120 is held, then cuts off the redundance of distal end titanium-nickel wire 7120；It is fixed using anti-drop head 7230 (for example, by using stirrup)
Proximal end titanium-nickel wire 7220, then cut off the redundance completion assembly of proximal end titanium-nickel wire 7220.
In other embodiment, referring to Figure 35, Figure 36, the 7110 central area shape of trying to get to the heart of a matter restrains to form interconnecting piece,
Its end is fixed by connector 7140 (for example, by using steel bushing), and shape restrains on the whole at the middle part of anchor portion, that is, collects to be formed
Proximal end titanium-nickel wire 7220, proximal end titanium-nickel wire 7220 passes through the hollow region of connector 7140 and opposite tense forms pretightning force, anchor
Determine portion and sealing and mutually push against the central region deformation at hub disk bottom further towards anchor portion protrusion, utilizes anti-drop head 7230
(for example, by using stirrup) fixed proximal end titanium-nickel wire 7220, then cut off the redundance completion assembly of proximal end titanium-nickel wire 7220.
In other embodiment, referring to Figure 37, Figure 38, the 7110 central area shape of trying to get to the heart of a matter restrains to form interconnecting piece,
I.e. central area collects to form distal end titanium-nickel wire 7120, and shape restrains on the whole at the middle part of anchor portion, that is, collects to form proximal end nickel
Titanium silk 7220.
Between distal end titanium-nickel wire 7120 and proximal end titanium-nickel wire 7220 by the way of being directly connected to, that is, connector is eliminated,
Visible 7220 bolt of proximal end titanium-nickel wire is wrapped in 7120 periphery of distal end titanium-nickel wire in figure, and in distal end, 7120 end of titanium-nickel wire is settable
The end of anti-drop head 7130 (for example, by using stirrup), proximal end titanium-nickel wire 7220 can be fixed on sealing by the way of welding
It tries to get to the heart of a matter position, can also be its spiral-shaped preparatory thermal finalization processing, when winding overcomes its elasticity expansion and again around the home remote
7120 periphery of titanium-nickel wire is held, moreover, distal end titanium-nickel wire 7120 can also use spiral way, mutual with proximal end titanium-nickel wire 7220
Around.
In other embodiment, referring to Figure 39, Figure 40,7110 global shapes of trying to get to the heart of a matter restrain to form interconnecting piece, i.e., integrally
It collects to form distal end titanium-nickel wire 7120, shape restrains to form interconnecting piece on the whole at the middle part of anchor portion, and end passes through connector
7210 is fixed (for example, by using steel bushings), and distal end titanium-nickel wire 7120 passes through the hollow part of the connector 7210 of anchor portion when assembly
And opposite tense forms pretightning force, finally utilizes (for example, by using the stirrup) stationary remote of anti-drop head 7130 titanium-nickel wire 7120, then cut
The redundance of distal end titanium-nickel wire 7120 is gone to complete assembly.
Disclosed above is only specific embodiments of the present invention, but the present invention is not limited to this, the technology of this field
Various changes and modifications can be made to the invention by personnel without departing from the spirit and scope of the present invention.Obviously these changes and change
Type should belong to the present invention claims protection scope protection in.In addition, although being used some specific terms in this specification,
These terms are merely for convenience of description, does not constitute to the present invention any specifically limited.
Claims (28)
1. a kind of occluder for left auricle being cross-linked, including sealing interconnected and anchor portion, which is characterized in that described
The reticular structure that there is anchor portion cutting to be formed, the sealing and anchor portion are respectively provided with the connection being made up of shape convergence
The interconnecting piece of both portion, sealing and anchor portion extends towards and the fixation that misplaces.
2. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the sealing and anchor portion two
The interconnecting piece of person is connected directly or is connected by connector.
3. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the sealing and anchor portion two
The interconnecting piece of person is mutually nested or deviate from each other at mutually matched position.
4. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the sealing and anchor portion two
The end that the interconnecting piece of person is extended towards and gone past the opponent.
5. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that both sealing and anchor portion exist
The peripheral region of respective interconnecting piece mutually reclines or pushes against.
6. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the sealing includes backwards to anchor
The disk of determining portion, the waist for trying to get to the heart of a matter and connecting disk and try to get to the heart of a matter towards anchor portion wherein described try to get to the heart of a matter is flat, or are tried to get to the heart of a matter
Middle part is towards anchor portion side protrusion, or middle part of trying to get to the heart of a matter is backwards to anchor portion side protrusion.
7. the occluder for left auricle being cross-linked as claimed in claim 6, which is characterized in that the sealing have not with anchor
The abutting state determining the pre-setting state of portion's contact and contacting with each other with anchor portion pushes against state relative to pre-setting state
Sealing in waist and/or try to get to the heart of a matter with deformation.
8. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the sealing is seal disc,
With the pre-setting state not contacted with anchor portion and the abutting state to contact with each other with anchor portion, relative to pre-setting shape
State pushes against sealing the trying to get to the heart of a matter with the axial deformation towards anchor portion towards anchor portion of state.
9. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the anchor portion is cut by tubing
It is formed, the reticular structure is the combination of hexagonal mesh or network structure or hexagonal mesh and network.
10. the occluder for left auricle being cross-linked as claimed in claim 9, which is characterized in that sealing is towards anchor portion one
Side is bottom, and described tubing one end is the interconnecting piece equipped with annular, and the interconnecting piece is connected with the bottom of sealing.
11. the occluder for left auricle being cross-linked as claimed in claim 10, which is characterized in that the anchor portion is by connector
Place extends backwards to sealing constitutes extended segment, and extended segment, which turns up to turn back far from the side of linkage section, constitutes folding to the bottom of sealing
Section is returned, the extended segment is taper, and major part side is far from sealing and opening setting.
12. the occluder for left auricle being cross-linked as claimed in claim 10, which is characterized in that the anchor portion is by connector
Place extends backwards to sealing constitutes extended segment, and extended segment, which turns up to turn back far from the side of linkage section, constitutes folding to the bottom of sealing
Section is returned, the back-turning section closes up to form closing in section in the bottom position infolding of sealing, the bottom of the closing in section and sealing
It offsets.
13. the occluder for left auricle being cross-linked as claimed in claim 12, which is characterized in that the anchor portion have not with
The pre-setting state that sealing pushes against and the abutting state that contacts with each other with sealing, under pre-setting state, in anchor portion axis
Upwards, the interconnecting piece of anchor portion is than closing in section further from sealing；Relative to pre-setting state, under abutting state, in anchor portion
In axial direction, the interconnecting piece of anchor portion is with respect to closing in section further towards sealing.
14. the occluder for left auricle being cross-linked as claimed in claim 13, which is characterized in that under abutting state, be anchored
In portion's axial direction, the interconnecting piece of anchor portion and closing in section flush or than closing in section further from sealing.
15. the occluder for left auricle being cross-linked as claimed in claim 5, which is characterized in that anchor portion has and sealing
The abutting position to offset, anchor portion is tubular structure under compression, and the abutting position is in the interior of tubular structure
Wall side.
16. the occluder for left auricle being cross-linked as claimed in claim 10, which is characterized in that the reticular structure is by being anchored
It is more support bars that the interconnecting piece in portion, which plays bifurcated, and support bar repeatedly crossed two-by-two, constitutes the reticular structure after bifurcated again.
17. the occluder for left auricle being cross-linked as claimed in claim 15, which is characterized in that in the reticular structure, two
Support bar is 20 ° -70 ° in the intersecting angle of intersection part.
18. the occluder for left auricle being cross-linked as claimed in claim 16, which is characterized in that anchor portion is in the support bar
Intersection part offset with sealing.
19. the occluder for left auricle being cross-linked as claimed in claim 18, which is characterized in that the support bar is by anchor portion
Interconnecting piece rise to end is extended to, mutually cross two-by-two 2~6 times therebetween, the end of the support bar is crossed two-by-two at one.
20. the occluder for left auricle being cross-linked as claimed in claim 10, which is characterized in that the periphery of the interconnecting piece is set
There are reinforcement garter spring, the cutting part reinforced garter spring and at least extend to anchor portion upwards in circumferential axis.
21. the occluder for left auricle being cross-linked as claimed in claim 18, which is characterized in that receive the bottom of the sealing
Beam and the interconnecting piece is passed through, the axial limiting portion of interconnecting piece of being limited to is equipped on being pierced by part, the axial limiting portion is
Banding is fixed on the anti-drop head that sealing collects periphery.
22. the occluder for left auricle being cross-linked as described in claim 1, which is characterized in that the anchor portion and sealing
For separate structure；The anchor portion and sealing mutually push against in assembling process.
23. the occluder for left auricle being cross-linked as claimed in claim 22, which is characterized in that the sealing and anchor portion
It is assembled after completing thermal finalization, sealing and anchor portion have the first state of initial contact when assembly；
Connecting portion between sealing and anchor portion also has the second state after being axially towards one another movement preset distance.
24. the occluder for left auricle being cross-linked as claimed in claim 23, which is characterized in that the sealing and anchor portion
Between connecting portion both be located at radial middle part, in interconnecting piece between the sealing and anchor portion under first state
The peripheral region of position is in contact.
25. the occluder for left auricle being cross-linked as claimed in claim 24, which is characterized in that relative to first state,
It moves close to more towards anchor portion side at the position being connect on sealing with anchor portion in second state.
26. the occluder for left auricle being cross-linked as claimed in claim 23, which is characterized in that the expression of the preset distance
Mode is：
The axial force of connecting portion between sealing and anchor portion；Or
The pressure of contact site between sealing and anchor portion；Or
The deformation quantity at the position being connect on sealing with anchor portion.
27. the occluder for left auricle being cross-linked as claimed in claim 26, which is characterized in that the deformation quantity is sealing
The Axial changes amount of predetermined position or the angle of sealing predetermined position and sealing axis.
28. the assembly method for the occluder for left auricle that one kind is cross-linked as described in claim 1, which is characterized in that sealing
Portion and anchor portion are assembled after completing thermal finalization, and sealing and anchor portion are closer and when initially contacting mutually first when assembly
State；On the basis of first state, the connecting portion between sealing and anchor portion reaches after being axially towards one another movement preset distance
To the second state；
Connecting portion between sealing and anchor portion is fixed to each other, so that connecting portion is maintained at the second state and completes assembly.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720581650 | 2017-05-23 | ||
| CN2017205816509 | 2017-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108926369A true CN108926369A (en) | 2018-12-04 |
Family
ID=64449133
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810480320.XA Pending CN108926369A (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle and its assembly method being cross-linked |
| CN201810481172.3A Active CN108926370B (en) | 2017-05-23 | 2018-05-18 | Left auricle plugging device capable of improving sealing effect and assembling method thereof |
| CN201810480128.0A Pending CN108926368A (en) | 2017-05-23 | 2018-05-18 | It is a kind of to use the occluder for left auricle and its assembly method for being cross-linked structure |
| CN201820749254.7U Active CN208958226U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle of closed loop configuration |
| CN201820749240.5U Active CN208958225U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle for improving shape |
| CN201810482033.2A Active CN108926371B (en) | 2017-05-23 | 2018-05-18 | Left auricle plugging device with closed-loop structure and assembly method thereof |
| CN201820749521.0U Active CN209074752U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle being cross-linked |
| CN201820749196.8U Active CN208958224U (en) | 2017-05-23 | 2018-05-18 | It is a kind of to use the occluder for left auricle for being cross-linked structure |
| CN201820749252.8U Active CN209074751U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle improving sealing effect |
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| CN201810481172.3A Active CN108926370B (en) | 2017-05-23 | 2018-05-18 | Left auricle plugging device capable of improving sealing effect and assembling method thereof |
| CN201810480128.0A Pending CN108926368A (en) | 2017-05-23 | 2018-05-18 | It is a kind of to use the occluder for left auricle and its assembly method for being cross-linked structure |
| CN201820749254.7U Active CN208958226U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle of closed loop configuration |
| CN201820749240.5U Active CN208958225U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle for improving shape |
| CN201810482033.2A Active CN108926371B (en) | 2017-05-23 | 2018-05-18 | Left auricle plugging device with closed-loop structure and assembly method thereof |
| CN201820749521.0U Active CN209074752U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle being cross-linked |
| CN201820749196.8U Active CN208958224U (en) | 2017-05-23 | 2018-05-18 | It is a kind of to use the occluder for left auricle for being cross-linked structure |
| CN201820749252.8U Active CN209074751U (en) | 2017-05-23 | 2018-05-18 | A kind of occluder for left auricle improving sealing effect |
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| EP3294150B1 (en) * | 2015-05-14 | 2021-12-15 | W. L. Gore & Associates, Inc. | Devices for occlusion of an atrial appendage |
| CN108926369A (en) * | 2017-05-23 | 2018-12-04 | 杭州诺茂医疗科技有限公司 | A kind of occluder for left auricle and its assembly method being cross-linked |
| CN109498073A (en) * | 2018-12-30 | 2019-03-22 | 上海形状记忆合金材料有限公司 | A kind of safety device for preventing heart implantation instrument from falling off, method and its application |
| CN110025350A (en) * | 2019-05-08 | 2019-07-19 | 广东脉搏医疗科技有限公司 | The adjustable occluder for left auricle for having sliding damping |
| AU2020300851A1 (en) * | 2019-07-02 | 2022-02-24 | Append Medical Ltd. | Left atrial appendage manipulation |
| CN110507373A (en) * | 2019-07-08 | 2019-11-29 | 江苏省肿瘤医院 | A kind of medical plugging system |
| CN114617603B (en) * | 2020-12-10 | 2024-04-02 | 先健科技(深圳)有限公司 | Plugging device |
| CN114617602A (en) * | 2020-12-10 | 2022-06-14 | 先健科技(深圳)有限公司 | Plugging device |
| CN112315523B (en) * | 2021-01-05 | 2021-06-04 | 先健科技(深圳)有限公司 | Plugging device |
| CN114559642B (en) * | 2022-02-28 | 2023-07-21 | 上海形状记忆合金材料有限公司 | Method and device for preparing closing end of plugging device |
| CN115517735B (en) * | 2022-11-03 | 2023-08-01 | 先健科技(深圳)有限公司 | Plugging device |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN209074752U (en) | 2019-07-09 |
| CN108926370B (en) | 2024-04-16 |
| CN208958224U (en) | 2019-06-11 |
| CN108926371B (en) | 2024-04-16 |
| CN108926371A (en) | 2018-12-04 |
| CN209074751U (en) | 2019-07-09 |
| CN208958226U (en) | 2019-06-11 |
| CN108926368A (en) | 2018-12-04 |
| CN108926370A (en) | 2018-12-04 |
| CN208958225U (en) | 2019-06-11 |
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