CN1089153A - Dialysate for intestinal cavity and preparation thereof - Google Patents
Dialysate for intestinal cavity and preparation thereof Download PDFInfo
- Publication number
- CN1089153A CN1089153A CN93100588A CN93100588A CN1089153A CN 1089153 A CN1089153 A CN 1089153A CN 93100588 A CN93100588 A CN 93100588A CN 93100588 A CN93100588 A CN 93100588A CN 1089153 A CN1089153 A CN 1089153A
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- CN
- China
- Prior art keywords
- urease
- radix
- copper ion
- dialysis solution
- rhizoma rhei
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Dialysate for intestinal cavity and preparation thereof are particularly suitable for replacing peritoneal dialysis uremia are treated, and it has urease and nontoxic copper ion Cu
2+, nontoxic copper ion Cu
2+Sodium carbonate and the reacted product of copper sulfate are made with the sodium citrate reaction again, and urease can be effectively with urea decomposition ammonification in the body, again by nontoxic copper ion Cu
2+The synthetic ammoniacal copper complex ion of ammino is excreted.This dialysis solution low cost of manufacture, curative effect are reliable rapidly, and it is a kind of efficient dialysis solution of alternative peritoneal dialysis for clinical proof.
Description
The invention belongs to a kind of enzyme-ionic complexing agent medicine and preparation method thereof, this medicine is particularly suitable for clinically acute or chronic renal failure (uremia) being carried out dialysis treatment, is a kind of novel dialytic liquid that replaces peritoneal dialysis.
The uremia of treatment both at home and abroad at present generally adopts dialysis process, mainly contains three kinds: hemodialysis, peritoneal dialysis and colonic dialysis.Wherein effective with hemodialysis, peritoneal dialysis again, the colonic dialysis effect is relatively poor.But hemodialysis needs special installation, and the price height is difficult to popularize, peritoneal dialysis needs surgical cannula, easily accompanying infection, and can cause losing of a large number of nutrients in the body (as albumin etc.), make patient's body constitution weak more, resistance descends, and general patient also is difficult to bear economically; And colonic dialysis is difficult to reach the purpose of mitigate the disease because of the colon finite capacity.
The objective of the invention is to overcome the defective of existing various dialysis process, seek a kind of efficient, reliable, safety, economy, novel dialytic liquid easy to use and preparation method thereof,, improve patient's life quality with misery and the financial burden that alleviates the patient.
The object of the present invention is achieved like this:
A kind of dialysate for intestinal cavity, it has urease and nontoxic copper ion Cu
2+
In 1000 milliliters this dialysis solution, the content of urease can be controlled at least 1 gram, nontoxic copper ion Cu
2+Content can be controlled in 2-3.5 gram.
Its preparation method is with urease and nontoxic copper ion Cu
2+Mix nontoxic copper ion Cu wherein
2+Made with the sodium citrate reaction by sodium carbonate and the reacted product of copper sulfate, its course of reaction is again:
For reducing manufacturing cost, alleviate patient's financial burden, urease can be prepared as follows: elder generation is inoculated in Bacillus proteus and increases bacterium in the fluid medium, and then carries out centrifugation, gets its supernatant and makes.
Can add Ren sus domestica secretions in the dialysis solution to promote erythrocytic generation in patient's body, strengthen result of use, this Ren sus domestica secretions can adopt following method to make: earlier bright Ren sus domestica chopping, defibrination are added normal saline again, and then with its filtration, get its no meat slag filtrate and get final product in slurry.
The extract that also can add Chinese medicine Herba Leonuri and Radix Et Rhizoma Rhei in the dialysis solution, Herba Leonuri can be controlled in 100 with the raw material weight ratio of Radix Et Rhizoma Rhei: 2-5, this extract can make with the following method: add decocting and endure the medical filtration that will endure again and get final product in Herba Leonuri and Radix Et Rhizoma Rhei.
The mechanism of action of this dialysis solution is as follows:
At first the carbamide in the enteric cavity is decomposed ammonification by urease.
Ammonia forms very stable complex with nontoxic copper ion again and is excreted then:
4NH
3+ Cu
2＋+ (4.4 × 10
12)/(2.3 × 10
－13) ［Cu ( NH
3)
4］
2+
The using method of this dialysis solution is as follows:
1, face with before, dialysis solution is fully shaken up, load onto drip stand, connect tube for transfusion and male catheter, aerofluxus;
2, patient gets lateral position, anus paraffine oil a little that catheter is inserted the about 22cm of anal is dark;
3, controlled adjuster splashes into dialysis solution in the enteric cavity with 40 speed of per minute, and also graded is put into, each 100ml, 1 hour at interval;
4, patient has when just anticipating, tube drawing, and defecation is had a rest and is continued after 30 minutes to instil;
5, look the general per 24 hours 1000-2000ml of the state of an illness and be advisable, 15-30 days is a course of treatment.This dialysis solution also can be oral simultaneously.
The present invention has following advantage:
1, curative effect is reliable rapidly, and the specificity that improves renal function is arranged.
2, novel safety;
3, economical and practical, expense only reaches about 1/10th of peritoneal dialysis.
4, production equipment is simple, and reagent source is wide, and production cost is low.
Embodiment:
1000ml is an example with preparation, and its concrete process for preparation is as follows:
1, separate urease: Bacillus proteus is inoculated in increases bacterium 24 hours in the 150ml fluid medium, make its antibacterial reach 1,000,000,000/ml(reduced turbidity), carry out centrifugation (4000 changeed 30 minutes) again, it is standby to get supernatant 100ml;
2, separate Ren sus domestica secretions: get bright Ren sus domestica 30 gram chopping, defibrinations, add normal saline 120ml, refilter, it is standby to get no slag filtrate 100ml;
3, produce the extract of Chinese medicine Herba Leonuri and Radix Et Rhizoma Rhei: get Herba Leonuri 100 gram and discharge water in right amount, endure to the 150ml, add Radix Et Rhizoma Rhei 3 grams, endured 5 minutes again, filter, it is standby to get liquid 100ml;
4, produce more stable nontoxic copper ion Cu
2+, get copper sulfate 3.5 grams and be dissolved in the 10ml water, in addition sodium citrate and each 2 gram of sodium carbonate are dissolved in the 70ml water, the heating hydrotropy, with in slow impouring sodium citrate of copper-bath and the sodium carbonate liquor, the limit edged stirs, and adds water to 100ml at last after the cooling;
5, mixing is regulated acid-base value: with above-mentioned each liquid mixing, add water to 1000ml, add sodium chloride 4-6 gram, and glucose 200-300 gram, benzoic acid 3 grams, potassium chloride 0.4-0.8 gram is regulated PH to 7.4-7.5, the aseptic sugar saline bottle of packing into, packing gets final product behind the discontinuous sterilization.
Claims (9)
1, a kind of dialysate for intestinal cavity is characterized in that it has urease and nontoxic copper ion Cu
2+
2, dialysis solution as claimed in claim 1 is characterized in that the content of urease in 1000 milliliters dialysis solution is at least 1 gram, nontoxic copper ion Cu
2+Content be 2-3.5 gram.
3, dialysis solution as claimed in claim 1 or 2 is characterized in that it also has Ren sus domestica secretions.
4, dialysis solution as claimed in claim 1 or 2 is characterized in that it also has the extract of Chinese medicine Herba Leonuri and Radix Et Rhizoma Rhei, and Herba Leonuri is 100 with the raw material weight ratio of Radix Et Rhizoma Rhei: 2-5.
5, dialysis solution as claimed in claim 3 is characterized in that it also has the extract of Chinese medicine Herba Leonuri and Radix Et Rhizoma Rhei, and Herba Leonuri is 100 with the raw material weight ratio of Radix Et Rhizoma Rhei: 2-5.
6, a kind of method for preparing dialysate for intestinal cavity is characterized in that it is with urease and nontoxic copper ion CU
2+Mix described nontoxic copper ion Cu
2+Made with the sodium citrate reaction by carbonic acid and the reacted product of copper sulfate, its course of reaction is again:
7, preparation method as claimed in claim 6 is characterized in that described urease is Bacillus proteus to be inoculated in increase bacterium in the fluid medium, gets after centrifugation that its supernatant makes again.
8, preparation method as claimed in claim 6 is characterized in that urease and nontoxic copper ion Cu
2+Mixture in added Ren sus domestica secretions, this Ren sus domestica secretions be with bright Ren sus domestica through chopping, add normal saline behind the defibrination, get after filtering again that no meat slag liquid makes.
9, as each described preparation method among the claim 6-8, it is characterized in that in mixture, adding the extract of Chinese medicine Herba Leonuri and Radix Et Rhizoma Rhei, this extract adds Herba Leonuri and Radix Et Rhizoma Rhei and makes after filtration after decocting is endured.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100588A CN1089153A (en) | 1993-01-03 | 1993-01-03 | Dialysate for intestinal cavity and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100588A CN1089153A (en) | 1993-01-03 | 1993-01-03 | Dialysate for intestinal cavity and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089153A true CN1089153A (en) | 1994-07-13 |
Family
ID=4983112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93100588A Pending CN1089153A (en) | 1993-01-03 | 1993-01-03 | Dialysate for intestinal cavity and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1089153A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431641C (en) * | 2002-04-08 | 2008-11-12 | 塑料管设计技术和艾里门拉芮工业贸易公司 | Method for measuring blood urea level by reverse iontophoresis |
-
1993
- 1993-01-03 CN CN93100588A patent/CN1089153A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431641C (en) * | 2002-04-08 | 2008-11-12 | 塑料管设计技术和艾里门拉芮工业贸易公司 | Method for measuring blood urea level by reverse iontophoresis |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |