CN108892639A - A kind of method that high-efficiency environment friendly prepares carbostyril compound - Google Patents
A kind of method that high-efficiency environment friendly prepares carbostyril compound Download PDFInfo
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- CN108892639A CN108892639A CN201810918488.4A CN201810918488A CN108892639A CN 108892639 A CN108892639 A CN 108892639A CN 201810918488 A CN201810918488 A CN 201810918488A CN 108892639 A CN108892639 A CN 108892639A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
The invention discloses a kind of methods that high-efficiency environment friendly prepares carbostyril compound.Fluoro ethyl benzoylacetate, triethyl orthoformate, aminated compounds are raw material, solvent-free and maintain 130 DEG C of reactions of temperature to synthesize carbostyril compound for 24 hours under conditions of without catalyst.Simultaneously after completion of the reaction, it is filtered by decompression and is washed using ethyl acetate, petroleum ether and methanol, product purity can be to 98.9% or more.The synthesis technology of quinolone of the present invention is simple and convenient to operate, yield is higher, environmentally protective.The preparation method of high-efficiency environment friendly synthesis carbostyril compound of the present invention is to feed intake to reduce cost of material together with dicarbonyl compound simple and easy to get, triethyl orthoformate and three component composition of aminated compounds, and use of the reaction process without any solvent and catalyst, fundamentally solve the problems such as former route pollution is larger, operation difficulty is high.
Description
Technical field
The invention belongs to chemical technology fields, and in particular to a kind of method that high-efficiency environment friendly prepares carbostyril compound.
Background technique
Carbostyril compound is by it with antimitotic, anticancer, antimalarial, antibacterial, antiviral, anti-diabetic, AntiHIV1 RT activity
It can be used as the nucleus module of a variety of drugs with bioactivity such as anti-inflammatories.For example, it is to be used as clinical treatment drug to have sand
Draw husky star, Norfloxacin, Pazufloxacin, An Tuosha star, Pu Lusha star, De Lasha star and angstrom for lattice Wei etc..
Quinolone drugs structure represents
The synthetic method of such drug is mostly based on Conrad Limpach, Gould Jacobs, Grohe Heitzer reaction
Deng.But since its response path is many and diverse, step is long, cost of material is high, while the three wastes environmental pollution that generating process generates
It is more serious that cause novel carbostyril drug price to remain high irreversible with destruction of the production process to environment.As can to it
Unnecessary link is reduced in production technology, can be reduced synthesis quinolone drugs price, be reduced the pollution to environment.
Summary of the invention
The purpose of the present invention is to provide a kind of methods that high-efficiency environment friendly prepares carbostyril compound.
The object of the present invention is achieved like this, is to be with dicarbonyl compound, triethyl orthoformate and aminated compounds
Raw material, while undergoing condensation reaction, substitution reaction and SN2Nucleophilic aromatic substitution reaction is prepared, and reaction principle is as follows：
The preparation method that high-efficiency environment friendly of the present invention prepares carbostyril compound is with dicarbapentaborane chemical combination simple and easy to get
Object, triethyl orthoformate and three component composition of aminated compounds feed intake reduce cost of material together, and reaction process is without any
The use of solvent and catalyst fundamentally solves the problems such as former route pollution is larger, operation difficulty is high.
Beneficial effects of the present invention are mainly reflected in：
1. the simple market of raw material can buy cheap；
2. three component raw materials feed intake one pot together and operate, intermediate does not need lock out operation, reaction process high-effective and labour-saving；
3. entire transition process efficiency, high final product does not need chromatography and simply washs that neat compounds just can be obtained；
4. the reaction process of safety, post-processing does not need column separation and only needs ethyl acetate and methanol washing and eluant, eluent
Can recycle can Pollution protection；
5. the reaction process of green, by-product only have ethyl alcohol, Atom economy high；
6. quinolone compounds practical value is high, the composed structure of important antibacterials.
Detailed description of the invention
Fig. 1 is No. 1 compound nuclear magnetic spectrum in the embodiment of the present invention 1；
Fig. 2 is No. 2 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 3 is No. 3 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 4 is No. 4 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 5 is No. 5 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 6 is No. 6 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 7 is No. 7 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 8 is No. 8 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Fig. 9 is No. 9 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Figure 10 is No. 10 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Figure 11 is No. 11 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Figure 12 is No. 12 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Figure 13 is No. 13 compound nuclear magnetic spectrums in the embodiment of the present invention 1；
Figure 14 is No. 1 compound nuclear magnetic spectrum in the embodiment of the present invention 2；
Figure 15 is No. 2 compound nuclear magnetic spectrums in the embodiment of the present invention 2；
Figure 16 is No. 3 compound nuclear magnetic spectrums in the embodiment of the present invention 2.
Specific embodiment
Below with reference to embodiment and attached drawing, the present invention is further illustrated, but is not subject in any way to the present invention
Limitation, based on present invention teach that it is made it is any transform or replace, all belong to the scope of protection of the present invention.
The method that high-efficiency environment friendly of the present invention prepares carbostyril compound is with dicarbonyl compound, orthoformic acid
Triethyl and aminated compounds are raw material, while undergoing condensation reaction, substitution reaction and SN2Nucleophilic aromatic substitution reaction is prepared into
It arrives, reaction principle is as follows：
The molar ratio of the dicarbonyl compound, triethyl orthoformate and aminated compounds is（0.5~1.5）:（0.5~
1.5）:（0.5~1.5）.
The molar ratio of the dicarbonyl compound, triethyl orthoformate and aminated compounds is 1:1:1.
The molar ratio of the dicarbonyl compound, triethyl orthoformate and aminated compounds is 1:1.25:1.
The dicarbonyl compound is 3-（2- halogenophenyl）- 3- oxo-propionate.
The dicarbonyl compound is 3-（2- fluorophenyl）- 3- oxo-propionate.
The two class compounds are aniline, pyridine amine or alkylamine.
It is under the conditions of solvent-free catalysis-free agent by three raw material investment reactions that high-efficiency environment friendly, which prepares carbostyril compound,
Device reacts 6 ~ 48h at 90 ~ 150 DEG C of temperature and obtains object carbostyril compound.
It after the reaction was completed further include decompression filtering and washing step.
The decompression filtering and washing is to carry out decompression filtering and washing using ethyl acetate, petroleum ether and methanol.
The decompression filtering and washing is the volume proportion 1 with 3 ~ 5 times of reaction product:The mixing of 1 ethyl acetate-light petrol is washed
It washs agent to wash 1 ~ 3 time, then is washed 1 ~ 2 time with 3 ~ 5 times of reaction product of methanol solution.
Quinolone compounds product is prepared in the method that high-efficiency environment friendly of the present invention prepares carbostyril compound
Purity can reach 98.9% or more.
Object carbostyril compound general structure of the present invention is：
Wherein, R1For alkyl or aryls such as hydrogen, halogen, methyl, ethyl, tert-butyl, methoxyl group, trifluoromethyl, cyano, nitros;
R2For the alkyl such as the aryl such as hydrogen or phenyl, pyridine or methyl, ethyl, cyclopropyl.
The technology path that high-efficiency environment friendly of the present invention prepares quinolone compounds is as follows：
Case is embodied, the present invention will be further described below：
The specification and detecting instrument of material used in the embodiment of the present invention or reagent are unless otherwise instructed commercially available.
Nuclear magnetic resonance spectrometer：Bruker Avance III 400MHz nuclear magnetic resonance spectrometer
Infrared waves spectrometer：Thermo Nicolet S10 FT-IR infrared waves spectrometer
Mass spectrograph：Agilent LC/MSD TOF instrument mass spectrometer
Melt point instalment：Beijing Tyke Tech X-5 melt point instalment
Embodiment 1
Embodiment reaction equation is as follows：
The preparation method includes the following steps：
The first step, under stirring, using dicarbapentaborane class compound, triethyl orthoformate, aniline as raw material, three components put into reaction together
In device, it is warming up to 130 DEG C of insulation reactions for 24 hours, stops reaction after there are a large amount of solids to be precipitated, obtain quinolone after fully reacting
Close object.Decompression filters, and is washed with petroleum ether, ethyl acetate and methanol washs, be dried to obtain quinolone compounds.
In embodiment aminated compounds variation be prepared carbostyril compound yield situation it is as follows：
Above compound nuclear magnetic spectrum is shown in that Fig. 1 ~ Figure 13, compound data are as follows：
Ethyl 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylate (1):Pale-pink
solid; yield 84%; m.p. 208-209 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ 8.46 (s,
1H), 8.30 (d, 1H, J = 7.72 Hz), 7.68 (s, 5H), 7.49 (t, 1H, J = 7.20 Hz), 7.39
(s, 1H), 6.98 (d, 1H, J = 8.40 Hz), 4.21 (t, 2H, J = 6.80 Hz), 1.28-1.18 (m,
3H); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ 173.4, 164.6, 148.9, 140.8, 133.2,
130.8, 130.4, 128.1, 127.9, 126.6, 125.9, 118.4, 110.9, 60.3, 14.7; IR (KBr):v max (cm-1) 3434, 3065, 1718, 1625, 1550, 1510, 1477, 1413, 1364, 1315, 1252,
1223, 1095, 1022, 862, 771, 862, 821, 771, 645, 549; HRMS (ESI-TOF+): m/z
Calcd for C18H16NO3 + [(M+H)+] 294.1125; found, 294.1122.
Ethyl 1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (2):
White solid; yield 92%; m.p. 179-199 oC; 1H NMR (400 MHz, CDCl3, ppm): δ 8.54
(d, 1H, J = 7.96Hz), 8.48 (s, 1H), 7.54 (t, 1H, J = 8.20 Hz), 7.49-7.41 (m,
3H), 7.33 (t, 2H, J = 8.08 Hz), 6.96 (d, 1H, J = 8.44 Hz), 4.42(q, 2H, J =
7.20 Hz), 1.40 (t, 3H, J = 7.12 Hz); 13C N MR (100 MHz, DMSO-d 6 , ppm): δ
174.3, 165.5, 164.2, 161.7, 148.6, 140.6, 136.6, 136.6, 132.4, 129.5, 129.4,
128.3, 127.6, 125.3, 117.6, 117.4, 117.3, 111.5, 61.0, 14.4; HRMS (ESI-TOF+):m/z Calcd for C18H14FNO3Na+ [(M+Na)+] 334.0850; found, 334.0850.
Ethyl 1-(4-nitrophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (3):
White solid; yield 90%; m.p. 171-173 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ
8.51 (t, 3H, J = 5.00 Hz), 8.29 (dd, 1H, J = 1.24, 1.24 Hz), 8.02 (d, 2H, J =
8.88 Hz), 7.68-7.64 (m, 1H), 7.50 (t, 1H, J = 7.64 Hz), 7.05 (d, 1H, J = 8.48
Hz), 4.24 (q, 2H, J = 7.20 Hz), 1.26 (t, 3H, J = 7.08 Hz); 13C NMR (100 MHz,
DMSO-d 6 , ppm): δ 173.5, 164.5, 148.4, 148.4, 145.9, 140.3, 133.3, 130.0,
127.8, 126.7, 126.0, 125.8, 118.2, 115.5, 60.4, 14.6; IR (KBr): v max (cm-1)
3444, 1724, 1613, 1526, 1476, 1350, 1252, 1216, 1135, 1097, 1020, 877, 767,
542; HRMS (ESI-TOF+): m/z Calcd for C18H14N2O5Na+ [(M+Na)+] 361.0795; found,
361.0788.
Ethyl 4-oxo-1-(4-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-
carboxylate (4): White solid; yield 93%; m.p. 204-206 oC; 1H NMR (400
MHz, DMSO-d 6 , ppm): δ 8.53 (s, 1H), 8.28 (d, 1H, J = 7.92 Hz), 8.09 (d, 2H, J
= 8.28 Hz), 7.97 (d, 2H, J = 8.16 Hz), 7.65 (t, 1H, J = 7.20 Hz), 7.49 (t,
1H, J = 7.36 Hz), 7.01 (d, 1H, J = 8.44 Hz), 4.23 (q, 2H, J = 6.80 Hz), 1.26
(t, 3H, J = 7.08 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ173.5, 164.5, 148.7,
144.1, 140.5, 133.3, 129.5, 127.9, 127.9, 127.8, 126.6, 125.7, 118.3, 111.3,
60.3, 14.6; IR (KBr): v max (cm-1) 3448, 1725, 1610, 1553, 1478, 1325, 1250,
1130, 1067, 542; HRMS (ESI-TOF+): m/z Calcd for C19H15F3NO3 + [(M+H)+] 362.999;
found, 362.0993.
Ethyl 4-oxo-1-(p-tolyl)-1,4-dihydroquinoline-3-carboxylate (5): White
solid; yield 74%; m.p. 199-201 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ 8.42 (s,
1H), 8.29 (dd, 1H, J = 1.36, 1.40 Hz), 7.67-7.62 (m, 1H), 7.54-7.46 (m, 1H),
6.98 (d, 2H, J = 8.48 Hz), 4.22 (d, 2H, J = 6.80 Hz), 2.50-2.45 (m, 3H), 1.26
(t, 3H, J = 7.12 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ 173.4, 164.6, 148.9,
141.0, 140.1, 138.4, 133.1, 131.2, 128.0, 127.8, 126.6, 125.5, 118.5, 110.9,
60.3, 21.2, 14.7; IR (KBr): v max (cm-1) 3433, 1724, 1625, 1550, 1473, 1406,
1314, 1243, 1207, 1125, 1090, 853, 769, 548; HRMS (ESI-TOF+): m/z Calcd for
C19H18NO3 + [(M+H)+] 308.1281; found, 308.1275.
Ethyl 1-(4-(tert-butyl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
(6): White solid; yield 76%; m.p. 207-209 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm):δ 8.45 (s, 1H), 8.29 (d, 1H, J = 7.76 Hz), 7.70-7.47 (m, 6H), 6.99 (d, 1H, J
= 8.40 Hz), 4.23 (q, 2H, J = 6.80 Hz), 1.37 (s, 9H), 1.26 (t, 3H, J = 6.96
Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ 173.4, 164.5, 152.9, 149.0, 140.9,
138.3, 133.2, 127.9, 127.5, 127.5, 126.6, 125.5, 118.5, 110.8, 60.3, 14.7; IR
(KBr): v max (cm-1) 3446, 1725, 1627, 1513, 1413, 1363, 1249, 1091, 1022, 764,
550; HRMS (ESI-TOF+): m/z Calcd for C22H24NO3 + [(M+H)+] 350.1751; found,
350.1746.
Ethyl 1-(2-bromophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (7):
White solid; yield 82%; m.p. 183-185 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ
8.48 (s, 1H), 8.30 (d, 1H, J = 7.96 Hz), 8.00 (d, 1H, J = 7.96 Hz), 7.88 (d,
1H, J = 7.72 Hz), 6.77 (d, 1H, J = 8.44 Hz), 7.73-7.61 (m, 3H), 7.50 (t, 3H,J = 7.40 Hz), 4.25 (q, 2H, J = 7.04 Hz), 1.27 (t, 3H, J = 7.08 Hz); 13C NMR
(100 MHz, DMSO-d 6 , ppm): δ173.5, 164.5, 148.7, 140.2, 139.1, 134.4, 133.5,
132.7, 131.0, 130.3, 127.7, 126.7, 125.7, 122.3, 117.9, 111.7, 60.5, 14.6; IR
(KBr): v max (cm-1) 3440, 1732, 1626, 1478, 1364, 1245, 1092, 810, 763, 543;
HRMS (ESI-TOF+): m/z Calcd for C18H14BrNO3Na+ [(M+Na)+] 396.0029; found,
396.0021.
Ethyl 1-(3-bromophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (8):
White solid; yield 85%; m.p. 267-269 oC; 1H NMR (400 MHz, F3CCOOD, ppm): δ
9.17 (s, 1H), 8.69 (d, 1H, J = 8.08 Hz), 8.04 (t, 1H, J = 7.00 Hz), 7.92-7.85
(m, 2H), 7.63-7.40 (m, 4H), 4.55 (q, 2H, J = 7.20 Hz), 1.35 (t, 3H, J = 6.68
Hz); 13C NMR (100 MHz, F3COOD, ppm): δ 176.0, 169.5, 151.2, 143.8, 141.8,
140.6, 137.8, 134.1, 132.6, 131.6, 127.9, 126.9, 126.6, 122.9, 67.2, 14.4; IR
(KBr): v max (cm-1) 3445, 2360, 1720, 1628, 1475, 1412, 1244, 1070, 1011, 767,
545; HRMS (ESI-TOF+): m/z Calcd for C18H14BrNO3Na+ [(M+Na)+] 396.0029; found,
396.0022.
Ethyl 1-(3-nitrophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (9):
White solid; yield 88%; m.p. 291-293 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ8.63
(t, 1H, J = 2.08 Hz), 8.55 (s,1H), 8.50-8.47 (m, 1H), 8.31 (dd, 1H, J = 1.36,
1.36 Hz), 8.16-8.14 (m, 1H), 7.95 (t, 1H, J = 8.16 Hz), 7.67-7.63 (m, 1H),
7.52-7.48 (m, 1H), 7.03 (d, 1H, J = 8.36 Hz), 4.23 (q, 2H, J = 6.80 Hz), 1.26
(t, 3H, J = 7.08 Hz); 13C NMR (100 MHz, F3CCOOD, ppm): 176.6, 169.6, 151.8,
151.5, 143.9, 142.0, 141.1, 135.4, 134.8, 133.0, 129.3, 128.4, 124.6, 121.5,
107.6, 67.5, 14.6; IR (KBr): v max (cm-1) 3430, 3059, 1724, 1608, 1530, 1476,
1348, 1312, 1250, 1095, 930, 763, 673, 540; HRMS (ESI-TOF+): m/z Calcd for
C18H14N2O5Na+ [(M+Na)+] 361.0795; found, 361.0794.
Ethyl 4-oxo-1-(m-tolyl)-1,4-dihydroquinoline-3-carboxylate (10): White
solid; yield 71%; m.p. 209-212 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ 8.43 (s,
1H), 8.29 (dd, 1H, J = 1.44, 1.44 Hz), 7.68-7.63 (m, 1H), 7.56 (t, 1H, J =
7.48 Hz), 7.50-7.43 (m, 4H), 6.99 (d, 1H, J = 8.44 Hz), 4.24 (q, 2H, J = 6.80
Hz), 2.42 (s, 3H), 1.26 (t, 3H, J = 7.08 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm):δ173.4, 164.6, 148.8, 140.8, 140.7, 133.1, 131.0, 130.5, 128.4, 127.9, 126.6,
125.5, 125.0, 118.5, 110.9, 60.3, 21.2, 14.7; IR (KBr): v max (cm-1) 3448, 1725,
1627, 1551, 1480, 1362, 1252, 1090, 763, 543; HRMS (ESI-TOF+): m/z Calcd for
C19H17NO3Na+ [(M+Na)+] 330.1101; found, 330.1097.
Ethyl 1-(3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (11):
White solid; yield 80%; m.p. 235-237 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ
8.46 (s,1H), 8.29 (d, 1H, J = 7.76 Hz), 7.69-7.47 (m, 3H), 7.31-7.21 (m, 3H),
7.03 (d, 1H, J = 8.36 Hz), 4.25 (q, 2H, J = 6.08 Hz), 3.83 (s, 3H), 1.27 (t,
3H, J = 6.84 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ 173.4, 164.6, 161.0,
148.8, 141.8, 140.8, 133.2, 131.5, 127.9, 126.5, 125.5, 119.9, 118.5, 116.4,
113.6, 110.8, 60.3, 56.1, 14.7; IR (KBr): v max (cm-1) 3442, 1725, 1605, 1477,
1364, 1341, 1266, 1230, 1093, 762, 552; HRMS (ESI-TOF+): m/z Calcd for
C19H14NO4Na+ [(M+Na)+] 346.1050; found, 346.1046.
Ethyl 1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
(12): White solid; yield 83%; m.p. 234-236 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm):
δ 8.49 (s,1H), 8.27 (d, 1H, J = 6.24 Hz), 7.99 (s, 1H), 7.77-7.49 (m, 4H),
7.04 (d, 1H, J = 7.88 Hz), 4.22 (d, 2H, J = 6.80 Hz), 1.26 (t, 3H, J = 6.84
Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): 173.5, 164.6, 148.9, 140.9, 137.2,
133.2, 127.8, 126.5, 126.0, 125.6, 119.4, 118.8, 118.4, 111.2, 60.3, 14.7; IR
(KBr): v max (cm-1) 3441, 3036, 1724, 1609, 1516, 1478, 1319, 1212, 1093, 1025,
911, 863, 766, 582; HRMS (ESI-TOF+): m/z Calcd for C18H13F2NO3Na+ [(M+Na)+]
352.0756; found, 352.0750.
Ethyl 4-oxo-1-(pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate (13):
White solid; yield 62%; Mp 235-242 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ 8.86
(t, 2H, J = 6.14 Hz), 8.55 (s, 1H), 8.30 (dd, 2H, J = 7.76, 7.64 Hz), 7.75-
7.65 (m, 2H), 7.51 (t, 1H, J = 7.40 Hz), 6.97 (d, 1H, J = 4.36 Hz), 4.24 (q,
2H, J = 6.80 Hz), 1.27 (t, 3H, J = 6.96 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm):δ 173.5, 164.6, 151.2, 149.1, 140.9, 137.6, 136.4, 133.3, 127.8, 126.6,
125.7, 125.3, 118.3, 114.4, 60.4, 14.7; IR (KBr): v max (cm-1) 3449, 1725, 1611,
1478, 1417, 1363, 1251, 1093, 1026, 766, 543; HRMS (ESI-TOF+): m/z Calcd for
C17H15N2O3 + [(M+H)+] 295.1077; found, 295.1080.
Embodiment 2
Embodiment reaction equation is as follows：
The preparation method includes the following steps：
The first step, under stirring, using dicarbapentaborane class compound, triethyl orthoformate, amine as raw material, three components put into reaction together
In device, it is warming up to 130 DEG C of insulation reactions for 24 hours, stops reaction after there are a large amount of solids to be precipitated, obtain quinolone after fully reacting
Close object.Decompression filters, and is washed with petroleum ether, ethyl acetate and methanol washs, be dried to obtain quinolone compounds.
In embodiment aminated compounds variation be prepared carbostyril compound yield situation it is as follows：
Above compound nuclear magnetic spectrum is shown in that Figure 14-Figure 16, compound data are as follows：
Ethyl 6,7-difluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-
carboxylate（1）White solid; yield 94%; m.p. >300oC; 1H NMR (400 MHz,
DMSO-d 6 , ppm): δ 8.45 (s, 1H), 8.07 (t, 1H, J = 8.96 Hz), 7.78 (s, 2H), 7.53
(t, 2H, J = 8.00 Hz), 7.04-6.99 (m, 1H), 4.20 (d, 2H, J = 6.76 Hz), 1.24 (t,
3H, J = 6.64 Hz); 13C NMR (100 MHz, DMSO-d 6 , ppm): δ 172.0, 164.2, 161.7,
149.7, 138.4, 136.8, 130.5, 130.4, 125.1, 117.9, 117.7, 114.2, 114.0, 110.8,
107.9, 107.9, 60.5, 14.6;HRMS (ESI-TOF+): m/z Calcd for C18H12F3NO3Na+ [(M+Na)+]
370.0661; found, 370.0662.
Ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
（2）White solid; yield 60%; m.p. >300oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ8.48
(s, 1H), 8.16-8.04 (m, 2H), 4.22-4.21 (m, 2H), 1.27 (s, 4H) 1.10 (s, 2H)；HRMS
(ESI-TOF+): m/z Calcd for C15H13F2NO3Na+ [(M+Na)+] 293.0863; found, 298.0863.
Ethyl 1-ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate （3）
White solid; yield 72%; m.p. >300 oC; 1H NMR (400 MHz, DMSO-d 6 , ppm): δ8.72
(s, 1H), 8.12-8.05 (m, 2H), 4.42 (t, 2H, J = 6.76 Hz), 4.39-4.22 (m, 2H),
4.04-4.00 (m, 2H), 1.99 (s, 3H); δ 170.8, 164.8, 149.9, 110.5, 110.3, 60.74,
60.22, 48.9, 21.2, 14.75;HRMS (ESI-TOF+): m/z Calcd for C14H13F2NO3Na+ [(M+Na)+]
281.0863; found, 281.0862。
Claims (10)
1. a kind of method that high-efficiency environment friendly prepares carbostyril compound, it is characterised in that be with dicarbonyl compound, orthoformic acid
Triethyl and aminated compounds are raw material, while undergoing condensation reaction, substitution reaction and SN2Nucleophilic aromatic substitution reaction is prepared into
It arrives, reaction principle is as follows：
。
2. the method that high-efficiency environment friendly according to claim 1 prepares carbostyril compound, it is characterised in that described two
The molar ratio of carbonyls, triethyl orthoformate and aminated compounds is（0.5~1.5）:（0.5~1.5）:（0.5~1.5）.
3. the method that high-efficiency environment friendly according to claim 2 prepares carbostyril compound, it is characterised in that described two
The molar ratio of carbonyls, triethyl orthoformate and aminated compounds is 1:1:1.
4. the method that any high-efficiency environment friendly prepares carbostyril compound according to claim 1 ~ 3, it is characterised in that institute
The molar ratio of dicarbonyl compound, triethyl orthoformate and the aminated compounds stated is 1:1.25:1.
5. the method that high-efficiency environment friendly according to claim 1 or 2 prepares carbostyril compound, it is characterised in that described
Dicarbonyl compound is 3-（2- halogenophenyl）- 3- oxo-propionate.
6. the method that high-efficiency environment friendly according to claim 5 prepares carbostyril compound, it is characterised in that described two
Carbonyls is 3-（2- fluorophenyl）- 3- oxo-propionate.
7. the method that high-efficiency environment friendly according to claim 1 or 2 prepares carbostyril compound, it is characterised in that described
Two class compounds are aniline, pyridine amine or alkylamine.
8. the method that high-efficiency environment friendly according to claim 1 prepares carbostyril compound, it is characterised in that high-efficiency environment friendly
Preparing carbostyril compound is by three raw material investment reactors under the conditions of solvent-free catalysis-free agent at 90 ~ 150 DEG C of temperature
6 ~ 48h of lower reaction obtains object carbostyril compound.
9. the method that high-efficiency environment friendly according to claim 1 prepares carbostyril compound, it is characterised in that reaction is completed
After further include decompression filtering and washing step.
10. the method that high-efficiency environment friendly according to claim 9 prepares carbostyril compound, it is characterised in that described subtracts
Pressure filtering and washing is to carry out decompression filtering and washing using ethyl acetate, petroleum ether and methanol.
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