CN108892626A - A kind of synthetic method of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane - Google Patents
A kind of synthetic method of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane Download PDFInfo
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Abstract
A kind of synthetic method of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane of the invention, includes the following steps：4.3 kilograms of dichloromethane solvent are added in one reaction kettle for step 1, and mixed liquor after mixing evenly, is down to 15 DEG C of set temperature hereinafter, obtaining mixed solution A by investment 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides；Iodomethane is added dropwise in step 2 in mixed solution A, and the reaction temperature for controlling mixed solution A and iodomethane is 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, and reaction temperature control is at 25 DEG C hereinafter, obtaining mixed solution B；Petroleum ether solvent is added in step 3, mixed solution B, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；Step 4, the drying material in vacuum that step 3 reaction is generated, obtains 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product.
Description
Technical field
The present invention relates to carbodiimides, and in particular to a kind of 1- ethyl -3- (3- dimethylamino-propyl) carbon
The synthetic method of diimine iodomethane.
Background technique
A kind of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane is mainly used as polypeptide, protein, nucleotide
Dehydrating agent in synthesis is, it can be achieved that the quick water-soluble type condensing agent of polypeptide condensation reaction.
1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane is water-soluble carbodiimide, and molecule is in line
Property structure, for the condensation reaction of carboxyl and primary amine, and has obtained extensive purposes.
In the prior art, it there are no synthesis 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane method
Document report.
Summary of the invention
The present invention is to overcome the shortcomings of the prior art, and it is mild that the present invention provides reaction conditions, and production equipment is simple,
Period is short, and yield is high, it is easy to accomplish a kind of industrial 1- ethyl -3- (3- dimethylaminopropyl)-carbonization of scale
The synthetic method of diimmonium salt hydrochlorate.
To achieve the above object, a kind of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane of the invention
Synthetic method includes the following steps：4.3 kilograms of dichloromethane solvent are added in one reaction kettle for step 1, put into 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides is down to 15 DEG C of set temperature hereinafter, being mixed after mixing evenly, by mixed liquor
Solution A；
Iodomethane is added dropwise in step 2 in mixed solution A, and the reaction temperature for controlling mixed solution A and iodomethane is 15 DEG C
~25 DEG C, be added dropwise iodomethane after the reaction was continued 1 hour, reaction temperature control at 25 DEG C hereinafter, obtaining mixed solution B；
Petroleum ether solvent is added in step 3, mixed solution B, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
Step 4, the drying material in vacuum that step 3 reaction is generated, obtains 1- ethyl -3- (3- dimethylaminopropyl)
Carbodiimides iodomethane finished product；
In step 1, the mass ratio of the methylene chloride and 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides
It is 4.3:1.0~1.1；
In step 2, the mass ratio of 1- ethyl -3- (3- the dimethylaminopropyl)-carbodiimides and iodomethane is
1：0.85~0.95；
In step 3,1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides and petroleum ether mass ratio be 1.0~
2.1:2.3。
Further, in step 1, in dichloromethane solvent, investment 1- ethyl -3- (3- dimethylaminopropyl) is added
After mixing evenly, it is 5 DEG C or less that mixed liquor is down to set temperature to carbodiimides.
Further, in step 4, the drying material in vacuum that step 3 reaction is generated, including be put into centrifuge and be centrifuged
1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane, vacuum drying condition are set as 65 DEG C of water temperature and are done
It is dry.
Further, the reaction formula of dropwise addition iodomethane is in mixed solution A：
。
Further, in step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3-
Dimethylaminopropyl) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution
A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.91 kilogram of iodomethane is added dropwise, be added dropwise
In the process, control reaction temperature is at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature
Control is at 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether agent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1-
Ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.55kg, yield 81.2%.
Further,
In step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylamino
Propyl) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.87 kilogram of iodomethane is added dropwise, be added dropwise
In the process, control reaction temperature is at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature
Control is at 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B be added 2.15 kilograms of petroleum ether solvent, keep the temperature 2 hours, temperature control 25 DEG C with
Under；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1-
Ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.45kg, yield 75.92%.
Further, in step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3-
Dimethylaminopropyl) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution
A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.9 kilogram of iodomethane is added dropwise, be added dropwise
Cheng Zhong controls reaction temperature at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
System is at 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B be added 2.15 kilograms of petroleum ether solvent, keep the temperature 2 hours, temperature control 25 DEG C with
Under；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1-
Ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.52kg, yield 79.6%.
Further, in step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3-
Dimethylaminopropyl) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution
A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.92 kilogram of iodomethane is added dropwise, be added dropwise
In the process, control reaction temperature is at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature
Control is at 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B be added 2.15 kilograms of petroleum ether solvent, keep the temperature 2 hours, temperature control 25 DEG C with
Under；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1-
Ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.53kg, yield 80.1%.
Further, in step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3-
Dimethylaminopropyl) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution
A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.94 kilogram of iodomethane is added dropwise, be added dropwise
In the process, control reaction temperature is at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature
Control is at 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B be added 2.15 kilograms of petroleum ether solvent, keep the temperature 2 hours, temperature control 25 DEG C with
Under；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1-
Ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.54kg, yield 80.6%.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) reaction process is simple, generates " 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides organic solvent " one
In place, production process can realize zero-emission, synthesis technology no pollution to the environment to step；
(2) reaction condition is mild safely, and yield is high, and solvent uses popular organic solvent, the chemicals of no hypertoxicity；
(3) feed intake and post-process simply, production cost is low, it is easy to accomplish industrialized production.
Specific embodiment
Following example, the present invention is further elaborated：
Embodiment 1
(1) 4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylaminopropyl)
1.0 kilograms of carbodiimides, starting stirs evenly, and is passed through chilled brine, starts to cool down, obtains mixed solution A.
(2) when solution A temperature to be mixed drops to 15 DEG C or less, start that 0.91 kilogram of iodomethane is added dropwise, during dropwise addition,
Temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, and in reaction process, temperature is controlled at 25 DEG C
Hereinafter, obtaining mixed solution B.
The reaction formula of dropwise addition iodomethane is in mixed solution A：
。
(3) 2.15 kilograms of petroleum ether solvent after reaction, are added in mixed solution B, keeps the temperature 2 hours, temperature control exists
25 DEG C or less.
(4) after the material that step 3 reaction generates being packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.55kg, yield 81.2%.
Embodiment 2
(1) 4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylaminopropyl)
1.0 kilograms of carbodiimides, starting stirring is passed through chilled brine, starts to cool down, obtain mixed solution A.
(2) when mixed solution A temperature to be obtained drops to 15 DEG C or less, start that 0.87 kilogram of iodomethane is added dropwise, process is added dropwise
In, temperature is controlled at 15 DEG C~25 DEG C, and the reaction was continued 1 hour after dropwise addition iodomethane, and in reaction process, temperature is controlled 25
DEG C hereinafter, obtaining mixed solution B.
(3) 2.15 kilograms of petroleum ether solvent are added in mixed solution B after reaction, keeps the temperature 2 hours, temperature control exists
25 DEG C or less.
(4) after the material that step 3 reaction generates being packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.45kg, yield 75.92%.
Embodiment 3
(1) 4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylaminopropyl)
1.0 kilograms of carbodiimides, starting stirring is passed through chilled brine, starts to cool down, obtain mixed solution A.
(2) when solution A temperature to be mixed drops to 15 DEG C or less, start that 0.90 kilogram of iodomethane is added dropwise, during dropwise addition,
Temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, and in reaction process, temperature is controlled at 25 DEG C
Hereinafter, obtaining mixed solution B.
(3) 2.15 kilograms of petroleum ether solvent are added in mixed solution B after reaction, keep the temperature 2 hours, temperature is controlled 25
DEG C or less.
(4) after the material that step 3 reaction generates being packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.52kg, yield 79.60%.
Embodiment 4
(1) 4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylaminopropyl)
1.0 kilograms of carbodiimides, starting stirring is passed through chilled brine, starts to cool down, obtain mixed solution A.
(2) when solution A temperature to be mixed drops to 15 DEG C or less, start that 0.92 kilogram of iodomethane is added dropwise, during dropwise addition,
Temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, and in reaction process, temperature is controlled at 25 DEG C
Hereinafter, obtaining mixed solution B.
(3) 2.15 kilograms of petroleum ether solvent are added in mixed solution B after reaction, keeps the temperature 2 hours, temperature control exists
25 DEG C or less.
(4) after the material that step 3 reaction generates being packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.53kg, yield 80.1%.
Embodiment 5
(1) 4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylaminopropyl)
1.0 kilograms of carbodiimides, starting stirring is passed through chilled brine, starts to cool down, obtain mixed solution A.
(2) when solution A temperature to be mixed drops to 15 DEG C or less, start that 0.94 kilogram of iodomethane is added dropwise, during dropwise addition,
Temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, and in reaction process, temperature is controlled at 25 DEG C
Hereinafter, obtaining mixed solution B.
(3) 2.15 kilograms of petroleum ether solvent are added in mixed solution B after reaction, keep the temperature 2 hours, temperature is controlled 25
DEG C or less.
(4) after the material that step 3 reaction generates being packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- ethyl -3-
(3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.54kg, yield 80.6%.
Organic solvent solvent 1.5kg is added in step 3 in mixed solution B after reaction, keeps the temperature 2 hours, temperature control
System is at 25 DEG C or less.
Step 4, dewatering container select without, by step 3 reaction generate material be packed into cloth bag after, be put into centrifuge from
The heart and drying, obtain 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimide hydrochloride finished product 0.98kg, and yield is
85.4%
Finally it should be noted that the above enumerated are only specific embodiments of the present invention.It is clear that the invention is not restricted to
Above embodiments can also have many variations.Those skilled in the art can directly lead from present disclosure
Out or all deformations for associating, it is considered as protection scope of the present invention.
Claims (9)
1. a kind of synthetic method of 1- ethyl -3- (3- dimethylamino-propyl) carbodiimide iodomethane, includes the following steps：
4.3 kilograms of dichloromethane solvent are added in one reaction kettle for step 1, put into 1- ethyl -3- (3- dimethylaminopropyl) -
Carbodiimides is down to 15 DEG C of set temperature hereinafter, obtaining mixed solution A after mixing evenly, by mixed liquor；
Iodomethane is added dropwise in step 2 in mixed solution A, and the reaction temperature for controlling mixed solution A and iodomethane is 15 DEG C~25
DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, and reaction temperature control is at 25 DEG C hereinafter, obtaining mixed solution B；
Petroleum ether solvent is added in step 3, mixed solution B, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
Step 4, the drying material in vacuum that step 3 reaction is generated, obtains 1- ethyl -3- (3- dimethylaminopropyl)-carbon
Change diimine iodomethane finished product；
In step 1, the mass ratio of the methylene chloride and 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides is
4.3:1.0~1.1；
In step 2, the mass ratio of 1- ethyl -3- (3- the dimethylaminopropyl)-carbodiimides and iodomethane is 1：
0.85~0.95；
In step 3,1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides and petroleum ether mass ratio are 1.0~2.1:
2.3。
2. synthetic method as described in claim 1, it is characterised in that：In step 1, in dichloromethane solvent, investment 1- is added
After mixing evenly, it is 5 DEG C or less that mixed liquor is down to set temperature to ethyl -3- (3- dimethylaminopropyl)-carbodiimides.
3. synthetic method as described in claim 1, it is characterised in that：In step 4, the material that step 3 reaction is generated is true
Sky is dry, including is put into centrifuge and is centrifuged to obtain 1- ethyl -3- (3- dimethylaminopropyl)-carbodiimides iodomethane, vacuum
Drying condition is set as 65 DEG C of water temperature and is dried.
4. the synthetic method as described in claim 1-3 any claim, it is characterised in that：Iodine is added dropwise in mixed solution A
The reaction formula of methane is：
。
5. the synthetic method as described in claim 1-3 any claim, it is characterised in that：In step 1, in a reaction kettle
4.3 kilograms of dichloromethane solvent are added, puts into 1.0 kilograms of-carbodiimides of 1- ethyl -3- (3- dimethylaminopropyl), opens
Dynamic stirring, is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.91 kilogram of iodomethane is added dropwise, process is added dropwise
In, reaction temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
At 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether solvent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- second
Base -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.55kg, yield 81.2%.
6. the synthetic method as described in claim 1-3 any claim, it is characterised in that：
In step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylamino third
Base) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.87 kilogram of iodomethane is added dropwise, process is added dropwise
In, reaction temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
At 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether solvent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- second
Base -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.45kg, yield 75.92%.
7. the synthetic method as described in claim 1-3 any claim, it is characterised in that：
In step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylamino third
Base) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.9 kilogram of iodomethane is added dropwise, process is added dropwise
In, reaction temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
At 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether solvent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- second
Base -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.52kg, yield 79.6%.
8. the synthetic method as described in claim 1-3 any claim, it is characterised in that：
In step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylamino third
Base) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.92 kilogram of iodomethane is added dropwise, process is added dropwise
In, reaction temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
At 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether solvent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- second
Base -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.53kg, yield 80.1%.
9. the synthetic method as described in claim 1-3 any claim, it is characterised in that：
In step 1,4.3 kilograms of dichloromethane solvent are added in a reaction kettle, puts into 1- ethyl -3- (3- dimethylamino third
Base) 1.0 kilograms of-carbodiimides, starting stirring is passed through chilled brine, starts cooling and obtains mixed solution A；
In step 2, when solution A temperature to be mixed drops to 15 DEG C or less, starts that 0.94 kilogram of iodomethane is added dropwise, process is added dropwise
In, reaction temperature is controlled at 15 DEG C~25 DEG C, the reaction was continued 1 hour after dropwise addition iodomethane, in reaction process, temperature control
At 25 DEG C hereinafter, obtaining mixed solution B；
In step 3, mixed solution B is added 2.15 kilograms of petroleum ether solvent, keeps the temperature 2 hours, and temperature is controlled at 25 DEG C or less；
In step 4, after the material that step 3 reaction generates is packed into cloth bag, it is put into centrifuge and is centrifuged and dries, obtain 1- second
Base -3- (3- dimethylaminopropyl)-carbodiimides iodomethane finished product 1.54kg, yield 80.6%.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103664700A (en) * | 2013-12-19 | 2014-03-26 | 浙江普康化工有限公司 | Synthesis method for 1-ethyl-3-(3-dimethyl amino propyl)-carbonized diimine A iodate |
| WO2017172313A1 (en) * | 2016-03-31 | 2017-10-05 | Dow Global Technologies Llc | Biscarbodiimides and polycarbodiimides and method for their preparation |
-
2018
- 2018-07-04 CN CN201810722773.9A patent/CN108892626A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103664700A (en) * | 2013-12-19 | 2014-03-26 | 浙江普康化工有限公司 | Synthesis method for 1-ethyl-3-(3-dimethyl amino propyl)-carbonized diimine A iodate |
| WO2017172313A1 (en) * | 2016-03-31 | 2017-10-05 | Dow Global Technologies Llc | Biscarbodiimides and polycarbodiimides and method for their preparation |
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