CN108876779A - Lung cancer method for early prediction, electronic equipment based on deep learning - Google Patents

Lung cancer method for early prediction, electronic equipment based on deep learning Download PDF

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Publication number
CN108876779A
CN108876779A CN201810648062.1A CN201810648062A CN108876779A CN 108876779 A CN108876779 A CN 108876779A CN 201810648062 A CN201810648062 A CN 201810648062A CN 108876779 A CN108876779 A CN 108876779A
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lung
image
design
data
shielding film
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周志光
马力
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Zhongshan Rising Vision Technology Co Ltd
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Zhongshan Rising Vision Technology Co Ltd
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/60Analysis of geometric attributes
    • G06T7/62Analysis of geometric attributes of area, perimeter, diameter or volume
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10081Computed x-ray tomography [CT]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30061Lung
    • G06T2207/30064Lung nodule

Abstract

The invention discloses the lung cancer method for early prediction based on deep learning, include the following steps:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;Pretreatment operation is carried out to the lung CT image data;Design Lung neoplasm detection model;Design Lung neoplasm disaggregated model;According to the sample number of every batch of training Lung neoplasm detection model.The present invention is converted into model by preprocessor etc. to original CT data can training data, and the model after training is deployed in server, patient lungs' tubercle after uploading CT data is detected using the model of the server, export nodule position and size, it predicts the good pernicious of tubercle, and the nodularity checked next time is predicted.

Description

Lung cancer method for early prediction, electronic equipment based on deep learning
Technical field
The present invention relates to CT images technologies, more particularly to the lung cancer method for early prediction based on deep learning and electronics are set It is standby.
Background technique
Lung cancer is one of highest malignant tumour of disease incidence inside malignant tumour, and five year survival rate is only 15% left side It is right.Therefore it finds and treats as soon as possible, cure rate could be improved.Lung cancer initial symptoms are very unobvious, it is easy to it is ignored, And reach an advanced stage, cancer metastasis can occur, cause to treat extremely difficult.Tumour association of the U.S. is a series of studies have shown that inspection Survey the very effective means that pulmonary nodule is early detection lung cancer.It is small-sized due to pulmonary nodule tumour, pass through Low-dose CT carries out early screening, can greatly improve the diagnosis of the early stage of lung cancer.
CT tomographic imaging is the very high three-dimensional imaging of resolution ratio, and data volume is huge.Each patient has several hundred tension faults Image.In lung cancer early stage, since tubercle very little, doctor are possible to generate solution because experience is insufficient or tired and misread at this time Accidentally.
Someone just put forward to use computer-aided diagnosis in the 1960s, was helped using the macrooperation amount of computer Doctor carry out diagnosis in traditional cad technique, mainly by have the people of many years of experience for different type disease detection come Design some characteristic values, such as using texture analysis, the various characteristic functions of edge detection and object detection, such as SIFT or HoG etc..The extraction of these features is realized by manually completely.This way objectively requires to read a large amount of cases, Cai Nengcong In sum up experience to instruct feature extraction.On the one hand, characteristic mass and limited amount directly result in the diagnosis of disease It is low;On the other hand, entirely different feature is designed for various disease, more increases degree of difficulty, this is also traditional CAD The reason of technology can not be soon applied in the different field of medicine.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide the lung cancer early stages based on deep learning Prediction technique, the problem of can solve pulmonary cancer diagnosis low efficiency in the prior art.
The second object of the present invention is to provide a kind of electronic equipment, can solve pulmonary cancer diagnosis low efficiency in the prior art The problem of.
An object of the present invention is implemented with the following technical solutions:
Lung cancer method for early prediction based on deep learning, includes the following steps:
Obtaining step:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
Processing step:Pretreatment operation is carried out to the lung CT image data;
Detection design step:Design Lung neoplasm detection model;
Classification design step:Design Lung neoplasm disaggregated model;
Model training step:According to the sample number of every batch of training Lung neoplasm detection model.
Preferably, the pretreatment operation specifically includes following sub-step:
Read lung CT image data;
Calculate every slice in arbitrary point arrive central point geometric distance, and remove geometric distance be greater than image_ Geometric distance of the point of size/2 to central point;Side is carried out using every sectioning image of the Gaussian filter to CT images data Edge sharpens;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;
To every slice by connection domain analysis, Retention area is greater than somin^2, and connection of the eccentricity less than 0.99 Domain;3D image analysing computer is done to CT images data, to remove impurity and background, and fills up duck eye in 3D image;
It repeats the above steps to generate maximum two UNICOM domains, which is left lung and right lung, and generates a left side The shielding film of lung and right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, If so, continuing to use shielding film, otherwise, convex closure is substituted into the shielding film;
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0, 255] gray value, and be multiplied the image value that every is sliced to obtain the segmentation data value of lung with gray value respectively;
CT images data are subjected to resampling, make the image as unit pixel representation space size of the corresponding slice of different patients Unanimously.
Preferably, detection design step specifically includes following sub-step:
The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;
Allowable loss function;
Design SGD optimizer.
Classification design step specifically includes following sub-step:
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;
Allowable loss function;
Design SGD optimizer.
It preferably, further include following steps:
Deploying step:Lung neoplasm detection model after training is deployed to server end, and constructs REST API server.
The second object of the present invention is implemented with the following technical solutions:
A kind of electronic equipment, including memory and processor are stored with the meter that can be executed by processor on the memory Calculation machine program, the computer program realize following steps when being executed by processor:
Obtaining step:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
Processing step:Pretreatment operation is carried out to the lung CT image data;
Detection design step:Design Lung neoplasm detection model;
Classification design step:Design Lung neoplasm disaggregated model;
Model training step:According to the sample number of every batch of training Lung neoplasm detection model.
Preferably, the pretreatment operation specifically includes following sub-step:
Read lung CT image data;
Calculate every slice in arbitrary point arrive central point geometric distance, and remove geometric distance be greater than image_ Geometric distance of the point of size/2 to central point;Side is carried out using every sectioning image of the Gaussian filter to CT images data Edge sharpens;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;
To every slice by connection domain analysis, Retention area is greater than somin^2, and connection of the eccentricity less than 0.99 Domain;3D image analysing computer is done to CT images data, to remove impurity and background, and fills up duck eye in 3D image;
It repeats the above steps to generate maximum two UNICOM domains, which is left lung and right lung, and generates a left side The shielding film of lung and right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, If so, continuing to use shielding film, otherwise, convex closure is substituted into the shielding film;
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0, 255] gray value, and be multiplied the image value that every is sliced to obtain the segmentation data value of lung with gray value respectively;
CT images data are subjected to resampling, make the image as unit pixel representation space size of the corresponding slice of different patients Unanimously.
Preferably, detection design step specifically includes following sub-step:
The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;
Allowable loss function;
Design SGD optimizer.
Preferably, classification design step specifically includes following sub-step:
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;
Allowable loss function;
Design SGD optimizer.
Compared with prior art, the beneficial effects of the present invention are:
The present invention to original CT data by preprocessor etc. be converted into model can training data, and by the model after training It is deployed in server, patient lungs' tubercle after uploading CT data is detected using the model of the server, exports tubercle Position and size are predicted the good pernicious of tubercle, and are predicted the nodularity checked next time.
Detailed description of the invention
Fig. 1 is the flow chart of the lung cancer method for early prediction of the invention based on deep learning.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention:
As shown in Figure 1, the present invention provides a kind of lung cancer method for early prediction based on deep learning, following step is specifically included Suddenly:
S1:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
The lung CT image data that the present invention uses has LUNAdata, Data Science Bowl2017stage1data, LUNA data are MHD format, read data using SimpleITK tool, 2017 data of Data Science Bowl are DICOM Format reads data using dicom tool.
S2:Pretreatment operation is carried out to the lung CT image data;
In this step, lung CT image data is read;
Calculate every slice in arbitrary point arrive central point geometric distance, and remove geometric distance be greater than image_ Geometric distance of the point of size/2 to central point;Side is carried out using every sectioning image of the Gaussian filter to CT images data Edge sharpens;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;It is mono- that CT value unit is also known as Heng Shi Position, is named by the name of its inventor SirGreoffreyHounsfie1d, abbreviation Hu, for indicating group on CT image Knit the relative density of structure, that is, body some part for X-ray opaqueness.
To every slice by connection domain analysis, Retention area is greater than somin^2, and connection of the eccentricity less than 0.99 Domain;3D image analysing computer is done to CT images data, to remove impurity and background, and fills up duck eye in 3D image;UNICOM domain is general Refer in image with same pixel value and position it is adjacent foreground pixel point composition image-region (Region, Blob).Connection Logical regional analysis (Connected Component Analysis, Connected Component Labeling) refers to and will scheme Each connected region as in is found out and is marked.Connection regional analysis is a kind of in numerous application fields of image analysis processing More common and basic method.
It repeats the above steps to generate maximum two UNICOM domains, which is left lung and right lung, and generates a left side The shielding film of lung and right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, If so, continuing to use shielding film, otherwise, convex closure is substituted into the shielding film;For two-dimensional image, convex closure is exactly will be outermost The point of layer connects composition convex polygon, it can concentrate all points comprising point.
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0, 255] gray value, and be multiplied the image value that every is sliced to obtain the segmentation data value of lung with gray value respectively;Expansion is Most basic operation in morphology goes scanning original image with a core, replaces anchor point position with the max pixel value of core institute overlay area The pixel set.
CT images data are subjected to resampling, make the image as unit pixel representation space size of the corresponding slice of different patients Unanimously.
When being the data of DICOM format, treated image data is saved, reads annatations data, it will Annatations resampling saves treated label data, at that time when the data of MHD format, reads annatations number The spatial information in annatations is mapped on the voxel coordinate system of image by world coordinates after, then will Annatations resampling simultaneously saves treated label data.
S3:Design Lung neoplasm detection model;
Specially:The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;Lung neoplasm detects net Network integrally uses 3DFasterRCNN because task only there are two classify (tubercle and background), prediction target directly as Testing result, without carrying out the classification of second stage.Basic network part uses Unet+Resnet18 framework, and the inside is each Resnet Block is made of multiple convolutional layers and bn layers and relu layers.Since negative sample is far more than positive sample, distribution is not It is similar to tubercle to balance some negative samples of, it is easy be accidentally divided into tubercle .hard negative mining and be used to handle this ask Topic.Originally it was negative example, positive example is but divided into very big probability, this part increases weight when calculating loss.Joint intersection (IoU) for determining that the sample of output is positive sample or negative sample.The IoU of target nodule is greater than 0.5 and pair less than 0.02 As by respectively as positive sample and negative sample.
Allowable loss function, comprising Bingary Cross Entropy (binary intersect entropy loss, for classifying) and SmothL1Loss (IoU of target nodule is greater than 0.5 and the object less than 0.02 is by respectively as positive sample and negative sample);
SGD optimizer is designed, parameter momentum=0.9, weight_decay=1e-4, wherein momentum are set For momentum, weight_decay is weight.
S4:Design Lung neoplasm disaggregated model;
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;Lung neoplasm sorter network uses 3DCNN network, Classification output Malignant Nodules probability.Network is made of two layers of full linking layer.Input data be upper note nodule detection network last A convolutional layer exports feature, this is the feature of 32 × 32 × 32 cube × 128, therefrom chooses confidence level highest 5 Tubercle feature.
Allowable loss function;Loss function by the imaginary tubercle of the confidence level of this five tubercles and one confidence level joint Probability is constituted, P=1- (1-Pd)∏i(1-Pi), wherein PdIt is the lung cancer probability for representing imaginary tubercle, PiRepresent 1--5 tubercle Lung cancer probability.
SGD optimizer is designed, parameter momentum=0.9, weight_decay=1e-4 are set.
S5:According to the sample number of every batch of training Lung neoplasm detection model, including learning rate, number of iterations, while training lung Nodule detection model and lung cancer prediction model.
Since training sample is 3D data, memory and video memory are expended, so batch quantity cannot be arranged excessive, first trains tubercle Network is detected, after so that network is exported effective tubercle, then joint training nodule detection and sorter network.
S6:Lung neoplasm detection model after training is deployed to server end, and constructs REST API server.
REST API server environment, including Python, PyTorch, Redis, Flask, modification Apache service are installed Device configuration file, creates web server code file, and client code file creates model server code file, creation WSGI configuration file establishes the soft link of project, copies trained model to server, starts Apache Web server, Start Redis database, Boot Model service.Server carries model, after client accesses server, using on server Model the CT data of patient are predicted.
Because the CT data of patient belong to sensitive information, model server is deployed in hospital internal network, and outer It needs to install Nvidia GPU on net isolation server hardware, needs that CUDA, CUDNN are installed on software.Server is installed to need Software package be:Python,PyTorch,Redis,Flask,Apache,WSGI,virtualenv.Edit the configuration of Apache File, additional project information, to be directed toward Flask application program.The code file for writing Web server receives client and is transmitted through The CT data come, and are pushed into Redis queue, continuous cycle request, until obtaining prediction data from model server, and by data Send back client.HTML the and JS file that client is shown is write, is used to and client carries out data interaction, receive CT number According to display prediction result.Model server code file is write, stress model is completed, the image in Redis queue is carried out pre- It surveys, is as a result also pushed into Redis queue.WSGI file is write, server directory is added to system path, and import web and answer With.The soft default directory for being linked to Apache of creation project.Because using GPU and CUDA, thus the library CUDA be flexible coupling to Under system directory/usr/lib, so that Apache can find CUDA library file.Model is copied to server, so as to model service Device load.Start Apache Web server, Redis database, model server with order.
The present invention also provides a kind of electronic equipment, including memory and processor, being stored on the memory can be located The computer program that device executes is managed, the computer program realizes following steps when being executed by processor:
Obtaining step:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
Processing step:Pretreatment operation is carried out to the lung CT image data;
Detection design step:Design Lung neoplasm detection model;
Classification design step:Design Lung neoplasm disaggregated model;
Model training step:According to the sample number of every batch of training Lung neoplasm detection model.
The pretreatment operation specifically includes following sub-step:
Read lung CT image data;
Calculate every slice in arbitrary point arrive central point geometric distance, and remove geometric distance be greater than image_ Geometric distance of the point of size/2 to central point;Side is carried out using every sectioning image of the Gaussian filter to CT images data Edge sharpens;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;
To every slice by connection domain analysis, Retention area is greater than somin^2, and connection of the eccentricity less than 0.99 Domain;3D image analysing computer is done to CT images data, to remove impurity and background, and fills up duck eye in 3D image;
It repeats the above steps to generate maximum two UNICOM domains, which is left lung and right lung, and generates a left side The shielding film of lung and right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, If so, continuing to use shielding film, otherwise, convex closure is substituted into the shielding film;
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0, 255] gray value, and be multiplied the image value that every is sliced to obtain the segmentation data value of lung with gray value respectively;
CT images data are subjected to resampling, make the image as unit pixel representation space size of the corresponding slice of different patients Unanimously.
Detection design step specifically includes following sub-step:
The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;
Allowable loss function;
Design SGD optimizer.
Classification design step specifically includes following sub-step:
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;
Allowable loss function;
Design SGD optimizer.
The present invention is mainly pre-processed by CT images, model training, and it is logical that model disposes three part composition original CT data collection Cross pretreatment, be converted into model can training data, be supplied to model be trained training after the completion of, model is saved and is deployed in Server end, using the model of server end, examines patient lungs' tubercle after having passed patient CT data on the client It surveys, exports nodule position and size, predict the good pernicious of tubercle, and predict the nodularity checked next time.
It will be apparent to those skilled in the art that can make various other according to the above description of the technical scheme and ideas Corresponding change and deformation, and all these changes and deformation all should belong to the protection scope of the claims in the present invention Within.

Claims (9)

1. the lung cancer method for early prediction based on deep learning, which is characterized in that include the following steps:
Obtaining step:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
Processing step:Pretreatment operation is carried out to the lung CT image data;
Detection design step:Design Lung neoplasm detection model;
Classification design step:Design Lung neoplasm disaggregated model;
Model training step:According to the sample number of every batch of training Lung neoplasm detection model.
2. lung cancer method for early prediction as described in claim 1, which is characterized in that the pretreatment operation specifically includes as follows Sub-step:
Read lung CT image data;
It calculates arbitrary point in every slice and arrives the geometric distance of central point, and remove geometric distance and be greater than image_size/2 Geometric distance of the point to central point;Edge sharpening is carried out using every sectioning image of the Gaussian filter to CT images data;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;
To every slice by connection domain analysis, Retention area is greater than somin^2, and UNICOM domain of the eccentricity less than 0.99;It is right CT images data do 3D image analysing computer, to remove impurity and background, and fill up duck eye in 3D image;
Repeat the above steps to generate maximum two UNICOM domains, two UNICOM domains be left lung and right lung, and generate left lung and The shielding film of right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, if so, Shielding film is then continued to use, otherwise, convex closure is substituted into the shielding film;
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0,255] Gray value, and respectively by every be sliced image value be multiplied to obtain the segmentation data value of lung with gray value;
CT images data are subjected to resampling, make the image as unit pixel representation space size one of the corresponding slice of different patients It causes.
3. lung cancer method for early prediction as claimed in claim 2, which is characterized in that detection design step specifically includes following son Step:
The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;
Allowable loss function;
Design SGD optimizer.
4. lung cancer method for early prediction as described in claim 1, which is characterized in that classification design step specifically includes following son Step:
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;
Allowable loss function;
Design SGD optimizer.
5. lung cancer method for early prediction as described in claim 1, which is characterized in that further include following steps:
Deploying step:Lung neoplasm detection model after training is deployed to server end, and constructs REST API server.
6. a kind of electronic equipment, including memory and processor, the calculating that can be executed by processor is stored on the memory Machine program, which is characterized in that the computer program realizes following steps when being executed by processor:
Obtaining step:Lung CT image data is obtained, the lung CT image data is made of several Lung sections;
Processing step:Pretreatment operation is carried out to the lung CT image data;
Detection design step:Design Lung neoplasm detection model;
Classification design step:Design Lung neoplasm disaggregated model;
Model training step:According to the sample number of every batch of training Lung neoplasm detection model.
7. electronic equipment as claimed in claim 6, which is characterized in that the pretreatment operation specifically includes following sub-step:
Read lung CT image data;
It calculates arbitrary point in every slice and arrives the geometric distance of central point, and remove geometric distance and be greater than image_size/2 Geometric distance of the point to central point;Edge sharpening is carried out using every sectioning image of the Gaussian filter to CT images data;
Using HU=600 as threshold value by every sectioning image binaryzation of CT images data;
To every slice by connection domain analysis, Retention area is greater than somin^2, and UNICOM domain of the eccentricity less than 0.99;It is right CT images data do 3D image analysing computer, to remove impurity and background, and fill up duck eye in 3D image;
Repeat the above steps to generate maximum two UNICOM domains, two UNICOM domains be left lung and right lung, and generate left lung and The shielding film of right lung;
The area for calculating the convex closure on shielding film judges the area of convex closure half whether bigger than the area of shielding film, if so, Shielding film is then continued to use, otherwise, convex closure is substituted into the shielding film;
Expansion process is done to shielding film, by linear transformation, the HU value [- 1200,600] that every is sliced is converted into [0,255] Gray value, and respectively by every be sliced image value be multiplied to obtain the segmentation data value of lung with gray value;
CT images data are subjected to resampling, make the image as unit pixel representation space size one of the corresponding slice of different patients It causes.
8. electronic equipment as claimed in claim 6, which is characterized in that detection design step specifically includes following sub-step:
The 3D convolutional neural networks based on U-NET and RESNET are designed, nodule detection is done;
Allowable loss function;
Design SGD optimizer.
9. electronic equipment as claimed in claim 6, which is characterized in that classification design step specifically includes following sub-step:
Three layers of 3D convolutional neural networks are designed to do the good pernicious prediction of tubercle;
Allowable loss function;
Design SGD optimizer.
CN201810648062.1A 2018-06-22 2018-06-22 Lung cancer method for early prediction, electronic equipment based on deep learning Pending CN108876779A (en)

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