CN108854763B - Shock-absorbing emulsion preparation instrument - Google Patents

Shock-absorbing emulsion preparation instrument Download PDF

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Publication number
CN108854763B
CN108854763B CN201710321898.6A CN201710321898A CN108854763B CN 108854763 B CN108854763 B CN 108854763B CN 201710321898 A CN201710321898 A CN 201710321898A CN 108854763 B CN108854763 B CN 108854763B
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China
Prior art keywords
plate
container
fixed
pressing
pressing block
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CN201710321898.6A
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Chinese (zh)
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CN108854763A (en
Inventor
盛司潼
冯传发
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Guangzhou Considerin Gene Health Technology Co ltd
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Guangzhou Considerin Gene Health Technology Co ltd
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Publication of CN108854763A publication Critical patent/CN108854763A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/24—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a rectilinear movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/70—Drives therefor, e.g. crank mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the technical field of biological sample processing devices, and provides a shock-absorbing emulsion preparation instrument; comprises a fixed plate, a bottom plate, a pressure strip, a supporting seat, a driving device, a locking device and a container fixing frame; the driving device is fixedly arranged on the fixing plate, the container fixing frame is arranged above the supporting seat through the locking device, and the driving device is used for driving the supporting seat to reciprocate on the bottom plate; the fixing plate is positioned above the bottom plate, the pressing plate is arranged on the bottom plate and used for pressing the fixing plate, and the pressing plate and the fixing plate and the bottom plate are elastically connected; the invention has the beneficial effects that: the vibration of the emulsion preparation instrument during operation is effectively reduced, and the emulsion preparation instrument cannot shake to a large extent.

Description

Shock-absorbing emulsion preparation instrument
Technical Field
The invention relates to the technical field of biological sample processing devices, in particular to a shock absorption emulsion preparation instrument.
Background
In the prior art, the emulsion preparation instrument generally adopts a reciprocating structure and mainly comprises a vibration instrument, a vibration arm, a grinding tank fixer, a centrifuge tube adapting hole, a power supply, a motion control and other components, wherein the vibration instrument is connected with the vibration arm, and the vibration arm is connected with the grinding tank fixer. The vibrator moves left and right or up and down at high frequency to drive the grinding tank on the grinding tank fixer to move left and right or up and down, and the steel balls in the grinding tank hit the oil-water mixture or the tissue sample at high speed, so that the sample is crushed or the emulsion is prepared.
The existing emulsion preparation instrument has the following general defects: the vibration of the emulsion preparation instrument is large due to the high-frequency left-right or up-down motion of the vibration instrument, and when the emulsion preparation instrument is placed on a table top for emulsion preparation, the emulsion preparation instrument can even move on the table top due to the large vibration; although the soft foot pad is arranged at the bottom of the emulsion preparation instrument to play a role in relieving the vibration to a certain extent, the emulsion preparation instrument still can shake to a large extent, and the damping effect is poor.
Therefore, there is a need for an emulsion preparation apparatus that can effectively reduce vibration and prevent large amplitude shaking.
Disclosure of Invention
The invention aims to provide a shock absorption emulsion preparation instrument, and aims to solve the problems that the emulsion preparation instrument in the prior art can vibrate to a large extent and has poor shock absorption effect.
In order to realize the purpose of the invention, the improvement of the shock absorption emulsion preparation instrument is that: comprises a fixed plate, a bottom plate, a pressure strip, a supporting seat, a driving device, a locking device and a container fixing frame;
the driving device is fixedly arranged on the fixing plate, the container fixing frame is arranged above the supporting seat through the locking device, and the driving device is used for driving the supporting seat to reciprocate on the fixing plate;
the fixed plate is positioned above the bottom plate, the pressing plate is arranged on the bottom plate and used for pressing the fixed plate, and the pressing plate and the fixed plate and the bottom plate are elastically connected.
In the structure, the compression plate is L-shaped and comprises a first vertical plate and a first limiting plate which are vertical to each other;
the first vertical plate is fixed on the bottom plate, the first limiting plate is located above the fixing plate, a first silica gel ball is arranged between the lower surface of the first limiting plate and the upper surface of the fixing plate, and a second silica gel ball is arranged between the lower surface of the fixing plate and the upper surface of the bottom plate.
Furthermore, the lower surface of the first limiting plate and the upper surface of the fixing plate are provided with spherical grooves for accommodating the first silica gel balls.
Further, the lower surface of the fixing plate is provided with a fixing groove, a backing ring and a compression nut are arranged in the fixing groove, a mounting hole for mounting a second silica gel ball is formed in the compression nut, and the second silica gel ball protrudes out of the mounting hole; the backing ring is located on the top of the second silica gel ball.
Furthermore, the bottom plate is square, and a pressing plate is fixed at four corners of the bottom plate.
In the above structure, the container fixing frame includes a container pressing plate, a first loading plate, a second loading plate, and a plurality of supporting columns; the plurality of supporting columns are fixed between the first loading plate and the second loading plate; the first loading plate is provided with a plurality of first through holes for inserting first containers, and the second loading plate is provided with a plurality of second through holes for inserting second containers;
the container pressing plate is connected to the first loading plate or the second loading plate and used for pressing the container cover of the first container or the container cover of the second container.
Furthermore, the container pressing plate is provided with a concave cavity, and the first loading plate or the second loading plate is positioned in the concave cavity of the container pressing plate.
Furthermore, the container fixing frame also comprises a soft pressing plate, and the soft pressing plate is positioned in a concave cavity of the container pressing plate;
a plurality of pressing blocks are arranged on one surface of the soft pressing plate facing the first loading plate or the second loading plate, and the pressing blocks are tightly pressed on the container cover of the first container or the container cover of the second container;
the other side of the soft pressing plate is provided with a plurality of positioning lugs, the inner surface of the cavity of the pressing block is provided with a plurality of positioning holes, and the positioning lugs are inserted into the positioning holes.
In the structure, the supporting seat comprises a transverse plate, a first vertical plate and a second vertical plate, the first vertical plate and the second vertical plate are parallel, and the first vertical plate and the second vertical plate are both vertical to the transverse plate;
the locking device is arranged on the first vertical plate, and the container fixing frame is arranged between the first vertical plate and the second vertical plate through the locking device.
Furthermore, locking device include knob, locking shaft and remove the briquetting, the one end and the knob fixed connection of locking shaft, the other end of locking shaft with remove briquetting threaded connection, the knob be used for through locking shaft drive remove the briquetting compress tightly on foretell container mount.
Furthermore, the locking device also comprises a fixed pressing block, the movable pressing block and the fixed pressing block are respectively positioned on two sides of the vertical plate of the supporting seat, and the fixed pressing block is fixed on the vertical plate;
a through hole is formed in the center of the fixed pressing block, and an internal thread is arranged in the through hole of the fixed pressing block; a through hole is formed in the center of the movable pressing block, and an internal thread is formed in the through hole of the movable pressing block; the vertical plate of the supporting seat is provided with a through hole, and the locking shaft penetrates through the through hole of the fixed pressing block, the through hole of the vertical plate and the through hole of the movable pressing block;
the locking shaft is provided with a first external thread and a second external thread, the turning direction of the first external thread is opposite to that of the second external thread, the first external thread is matched with the internal thread of the fixed pressing block, and the second external thread is matched with the internal thread of the movable pressing block;
the locking device further comprises a first positioning pin, the vertical plates of the movable pressing block and the supporting plate are correspondingly provided with first pin holes, and the first positioning pin is inserted into the first pin holes of the movable pressing block and the vertical plates to prevent the movable pressing block from rotating together with the locking shaft.
Furthermore, the locking device also comprises a movable pressing plate, the movable pressing plate is fixed on the movable pressing block, and the movable pressing plate is used for pressing the container fixing frame;
the container pressing plate is provided with a limiting groove, and when the container fixing frame is placed between the first vertical plate and the second vertical plate, the movable pressing plate is accommodated in the limiting groove of the container pressing plate.
In the above structure, the driving device includes a motor, a driving wheel, a crank, a guide rail and a slider;
the guide rail is fixedly arranged on the fixed plate, the sliding block is arranged on the guide rail in a sliding manner, and the supporting seat is fixed on the sliding block;
the motor be used for driving the drive wheel and rotate, the one end of crank is rotated and is connected on the drive wheel, drives the one end of crank through the drive wheel and rotates around the center pin, the other end of crank rotates and is connected to on the supporting seat to drive supporting seat reciprocating motion on the guide rail.
Furthermore, the driving device also comprises a first driving wheel, a driving belt, a second driving wheel and a connecting shaft; the first driving wheel is fixed on the output shaft of the motor, the second driving wheel is fixed at one end of the connecting shaft, and the other end of the connecting shaft is fixedly connected with the driving wheel; the transmission belt is sleeved on the first transmission wheel and the second transmission wheel.
According to the invention, as the compression plate and the fixed plate and the bottom plate are elastically connected, when the fixed plate vibrates, the vibration can be well relieved, and the vibration of the fixed plate is prevented from being transmitted to the bottom plate; the lower surface of the bottom plate is also provided with the silica gel pad, and when the emulsion preparation instrument is placed on a table top to prepare the emulsion, the silica gel pad can also play a role in relieving the integral vibration, so that the vibration of the emulsion preparation instrument during operation is effectively reduced, and the emulsion preparation instrument cannot shake to a greater extent; when the emulsion preparation instrument is placed on a table for operation, the shell and the bottom plate are basically in a static state.
Drawings
FIG. 1 is a schematic perspective view of a shock-absorbing emulsion preparation apparatus according to an embodiment of the present invention.
FIG. 2 is a schematic diagram of the internal structure of a vibration-damping emulsion preparation apparatus according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a fixing plate, a bottom plate and a pressing plate according to an embodiment of the present invention.
Fig. 4 is an exploded view of the fixed plate, the base plate and the pressing plate according to an embodiment of the present invention.
Fig. 5 is a schematic diagram of a first perspective structure of a compacting plate according to an embodiment of the invention.
Fig. 6 is a second perspective view of a hold-down plate in accordance with an embodiment of the present invention.
Fig. 7 is a partially enlarged view of the fixing plate and the second silicone ball according to an embodiment of the present invention.
Fig. 8 is a schematic perspective view of a pressing plate according to another embodiment of the present invention.
Fig. 9 is a bottom view of a hold-down plate in accordance with another embodiment of the invention.
Fig. 10 is a schematic perspective view of a container holder according to an embodiment of the present invention.
Fig. 11 is a second perspective view of a container holder according to an embodiment of the invention.
Fig. 12 is a schematic perspective view of a container holder according to another embodiment of the present invention.
Fig. 13 is a schematic view illustrating an installation process of the container holder according to another embodiment of the present invention.
Fig. 14 is a schematic view of an exploded structure of a container holder according to another embodiment of the present invention.
Fig. 15 is a schematic perspective view of a container platen and a soft platen according to another embodiment of the present invention.
Fig. 16 is a schematic perspective view of a support base and a locking device according to an embodiment of the present invention.
Fig. 17 is an exploded view of the support base and locking device in accordance with one embodiment of the present invention.
FIG. 18 is a top view of a support base and locking mechanism in accordance with one embodiment of the present invention.
Fig. 19 is a schematic cross-sectional view taken along line a-a in fig. 18.
FIG. 20 is a schematic view showing the internal structure of an apparatus for preparing an emulsion according to another embodiment of the present invention.
Fig. 21 is a schematic perspective view of a driving device according to an embodiment of the present invention.
Fig. 22 is an exploded view of a drive device in accordance with an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments.
The present invention provides a first embodiment, and the embodiment provides a vibration-damping emulsion preparation apparatus, as shown in fig. 1 to 3, the emulsion preparation apparatus includes a housing 10, a protection cover 101 is rotatably mounted on the housing 10, and the protection cover 101 is closed when the emulsion preparation apparatus works; the housing 10 is further provided with a display panel 102, and the display panel 102 displays the working state of the emulsion preparation apparatus. As shown in fig. 2, the emulsion preparation apparatus further comprises a fixing plate 70, a bottom plate 20, a pressing plate 80, a supporting seat 30, a driving device 50, a locking device 40 and a container fixing frame 60; the driving device 50 is fixedly installed on the fixing plate 70, the container fixing frame 60 is installed above the supporting seat 30 through the locking device 40, the driving device 50 is used for driving the supporting seat 30 to reciprocate on the fixing plate 70, the supporting seat 30 drives the container fixing frame 60 to reciprocate, and the steel balls strike an oil-water mixture in a container on the container fixing frame 60 at a high speed, so that the preparation of the emulsion is realized. The fixing plate 70 is located above the bottom plate 20, the pressing plate 80 is arranged on the bottom plate 20, the pressing plate 80 is used for pressing the fixing plate 70, and the pressing plate 80 and the fixing plate 70, and the fixing plate 70 and the bottom plate 20 are elastically connected.
With this structure, when the driving device 50 drives the container holder 60 to reciprocate, the fixing plate 70 and the device above the fixing plate 70 vibrate due to the reciprocating motion of the container holder 60 and the supporting seat 30; the fixing plate 70 is fixed on the bottom plate 20 under the action of the pressing plate 80, and meanwhile, the elastic connection is formed between the pressing plate 80 and the fixing plate 70 and between the fixing plate 70 and the bottom plate 20, so that the vibration can be well relieved when the fixing plate 70 vibrates, and the vibration of the fixing plate 70 is prevented from being transmitted to the bottom plate 20; in addition, the lower surface of the bottom plate 20 is also provided with a silica gel pad 201, and when the emulsion preparation instrument is placed on a table top for emulsion preparation, the silica gel pad 201 can also play a role in relieving the integral vibration, so that the emulsion preparation instrument effectively reduces the vibration of the emulsion preparation instrument during operation and can not shake to a greater extent; when the emulsion preparation instrument of the present invention is placed on a table for operation, the housing 10 and the base plate 20 are substantially in a static state, which enhances the experience of using the product.
In the above embodiment, as for the pressing plate 80 and the connection manner between the pressing plate 80 and the fixing plate 70 and the bottom plate 20, the invention provides a specific embodiment, as shown in fig. 4 to 7, the pressing plate 80 is L-shaped, and includes a first vertical plate 801 and a first limiting plate 802 that are perpendicular to each other, a through screw hole 803 is provided on the first vertical plate 801, a fixing hole is correspondingly provided on the bottom plate 20, and the first vertical plate 801 is perpendicularly fixed on the bottom plate 20 by locking screws into the screw hole 803 of the first vertical plate 801 and the fixing hole of the bottom plate 20; the first limiting plate 802 is located above the fixing plate 70 and spaced from the fixing plate 70 by a preset distance, a first silicone ball 901 is disposed between the lower surface of the first limiting plate 802 and the upper surface of the fixing plate 70, and a second silicone ball 902 is disposed between the lower surface of the fixing plate 70 and the upper surface of the base plate 20.
Further, as shown in fig. 4 and fig. 6, in the present embodiment, the bottom plate 20 and the fixing plate 70 are both square, and the fixing plate 70 is provided with a plurality of notches for mounting other components; the fixed plate 70 is slightly smaller than the base plate 20, and a pressing plate 80 is fixed at each of four corners of the base plate 20. The lower surface of the first limiting plate 802 is provided with a spherical groove 8021 for accommodating the first silicone ball 901, the upper surface of the fixing plate 70 is also provided with a spherical groove 704 for accommodating the first silicone ball 901, and the spherical radians of the spherical grooves 8021, 704 are larger than the spherical radians of the first silicone ball 901, that is, the diameters of the spheres where the spherical grooves 8021, 704 are located are larger than the diameter of the first silicone ball 901; therefore, after the first silicone ball 901 is accommodated in the spherical grooves 8021 and 704, the first silicone ball 901 can displace in small amplitude in the spherical grooves 8021 and 704, but meanwhile, due to the limiting effect of the spherical grooves 8021 and 704, the first silicone ball 901 tends to be always located at the center positions of the spherical grooves 8021 and 704, and the position of the first silicone ball 901 can be prevented from being deviated. Therefore, when emulsion is prepared, the supporting seat 30 reciprocates on the bottom plate 20, the fixing plate 70 vibrates, the fixing plate 70 can shake on the bottom plate 20 to a small extent under the action of the first silica gel balls 901 at the four corners of the fixing plate 70 and the pressing plate 80, when the fixing plate 70 vibrates, the vibration of the fixing plate 70 is buffered through the deformation of the first silica gel balls 901, and when the fixing plate 70 shakes, the first silica gel balls 901 roll in the spherical grooves 8021 and 704, so that the vibration and shaking of the fixing plate 70 can be prevented from being transmitted to the pressing plate 80, and the pressing plate 80 and the bottom plate 20 are always in a stable state; meanwhile, the second silica gel ball 902 between the fixing plate 70 and the bottom plate 20 has a good shock absorption effect, the lower surface of the second silica gel ball 902 is in contact with the upper surface of the bottom plate 20, and the vibration and shaking of the fixing plate 70 can be prevented from being transmitted to the bottom plate 20 under the elastic effect of the second silica gel ball 902, so that the vibration of the emulsion preparation instrument during operation is reduced. As shown in fig. 7, in this embodiment, the fixing plate 70 is provided with a fixing groove 701 on a lower surface thereof, a gasket 702 and a pressing nut 703 are provided in the fixing groove 701, the pressing nut 703 is provided with an installation hole 7031 for installing the second silicone ball 902, the installation hole 7031 is a step through hole, the second silicone ball 902 is basically accommodated in the installation hole 7031, a bottom of the second silicone ball 902 protrudes from the installation hole 7031 and is attached to the bottom plate 20, and the gasket 702 is located at a top of the second silicone ball 902 and abuts against a bottom of the second silicone ball 902. In the above embodiment, the supporting seat 30 and the container fixing frame 60 reciprocate on the fixing plate 70 along the length direction of the fixing plate 70, so that the fixing plate 70 mainly vibrates along the length direction thereof, and the first vertical plate 801 of the pressing plate 80 is flush with the length direction of the fixing plate 70 and fixed on the side edge of the bottom plate 20; when the fixing plate 70 vibrates along the length direction of the fixing plate, the first vertical plate 801 of the pressing plate 80 is prevented from touching the fixing plate 70, and a vibrating space of the fixing plate 70 does not need to be reserved in the length direction of the fixing plate 70, so that the structures of the fixing plate 70 and the pressing plate 80 are more compact.
As for the pressing plate 80, the present invention further provides an embodiment, as shown in fig. 8 and 9, similarly, the pressing plate 80 is L-shaped, and includes a first vertical plate 801 and a first limiting plate 802 that are perpendicular to each other, a first spherical groove 8024 for accommodating the first silicone ball 901 is disposed on a lower surface of the first limiting plate 802, which is different from the above-mentioned embodiment only in that an opening of the first spherical groove 8024 is racetrack-shaped, the opening is composed of semicircular arc edges 8022 with two symmetrical ends and a straight edge 8023 connecting the semicircular arc edges 8022, and a symmetrical line of the two semicircular arc edges 8022 is perpendicular to the first vertical plate 801; the first spherical groove 8024 is composed of a spherical surface 8025 and a semi-cylindrical surface 8026 which are symmetrical, wherein the spherical surface 8025 is a quarter of a spherical surface, and the diameters of the spherical surface 8025 and the semi-cylindrical surface 8026 are equal to the diameter of the first silicone ball 901 or slightly larger than the diameter of the first silicone ball 901, when the first silicone ball 901 is accommodated in the first spherical groove 8021, the first silicone ball 901 can displace in the first spherical groove 8022, but at the same time, due to the limiting effect of the first spherical groove 704, after the emulsion preparation instrument stops operating, the first silicone ball 901 always tends to be at the central positions of the first spherical grooves 8022 and 704, so that the position of the first silicone ball 901 can be prevented from deviating, and the fixing plate 70 is located at the central position above the bottom plate 20 after being stationary.
As for the container fixing frame, as shown in fig. 10 to 15, the invention provides a specific embodiment, the container fixing frame 60 includes a container pressing plate 601, a first loading plate 602, a second loading plate 603, and a plurality of supporting columns 604, the plurality of supporting columns 604 are fixed between the first loading plate 602 and the second loading plate 603, in this embodiment, as shown in fig. 11, the container fixing frame 60 includes four supporting columns 604, the first loading plate 602 and the second loading plate 603 are both square, the four supporting columns 604 are all located at the top corners of the first loading plate 602 and the second loading plate 603, and the first loading plate 602 and the second loading plate 603 are fixed by locking screws; a positioning pin 605 is further provided at the center of the first load plate 602 and the second load plate 603, and the positioning pin 605 serves to prevent the position of the first load plate 602 and the second load plate 603 from being deviated, and also has an effect of reinforcing the strength of the first load plate 602 and the second load plate 603. A plurality of first through holes 6021 for inserting the first container are formed in the first loading plate 602, and a plurality of second through holes 6031 for inserting the second container are formed in the second loading plate 603; the container pressing plate 601 is connected to the first loading plate 602 or the second loading plate 603, and is used for pressing the container cover of the first container or the container cover of the second container. As shown in fig. 10, which is a specific embodiment of the container holder 60, the first through holes 6021 of the first loading plate 602 are used for inserting test tubes 606, when emulsion preparation is required, the container holder 60 is placed on a table, the second loading plate 603 is attached to the table, after the container pressing plate 601 is removed from the first loading plate 602, the test tubes 606 are sequentially inserted into each first through hole 6021, the test tubes 606 are arranged in a rectangular array, the container pressing plate 601 is pressed against the first loading plate 602, and the container pressing plate 601 presses a cover on the test tubes 606 to prevent the oil-water mixture from flowing out of the test tubes. Thereafter, the container holder 60 and the test tube are put in their entirety on the support base 30 of the emulsion preparing apparatus, and the container holder 60 is locked by the locking device 40.
When emulsion preparation needs to be realized in another container, as shown in fig. 12, the present invention provides an embodiment, the container is a 96-well plate 607, the second loading plate 603 is provided with second through holes 6031 with the same number, the aperture of the second through hole 6031 is slightly larger than the outer diameter of each reagent hole on the 96-well plate 607, similarly, when emulsion preparation is performed, the container fixing frame 60 is placed on a table top, the first loading plate 602 is attached to the table top, after the container pressing plate 601 is taken down from the second loading plate 603, the 96-well plate 607 is placed on the second loading plate 603, each hole of the 96-well plate 607 is filled with a mixture of steel balls and oil and water, the upper surface of the 96-well plate 607 is provided with a rubber pad, each hole of the 96-well plate is sealed by the rubber pad, the rubber pad is an integral structure, as shown in fig. 13, the container pressing plate 601 is pressed on the second loading plate 603, the container pressing plate 601 is tightly pressed on the rubber mat to prevent the oil-water mixture from flowing out of the holes of the 96-hole plate; then, the container holder 60 is placed on the supporting seat 30, and the container holder 60 is locked by the locking device 40; starting the emulsion preparation instrument, driving the container fixing frame 60 to reciprocate on the bottom plate 20 by the driving device 50, and striking the oil-water mixture at high speed by steel balls in the test tube holes of the 96-well plate 607 to realize the preparation of the water-in-oil emulsion. The same container fixing frame 60 of the emulsion preparation instrument can be at least suitable for containers with two different specifications, and the two containers with the two different specifications can realize the preparation of the emulsion in the same emulsion preparation; the first loading plate 602 or the second loading plate 603 can be replaced according to the size of the container, or the container fixing frames 60 with different specifications can be directly designed, so that the emulsion preparation instrument is suitable for containers with different specifications.
As shown in fig. 14 and fig. 15, for the container pressing plate 601, a specific embodiment of the present invention is provided, the container pressing plate 601 has a cavity 6011, the first loading plate 602 or the second loading plate 603 is located in the cavity 6011 of the container pressing plate 601, and the container fixing frame 60 further includes a soft pressing plate 608, the soft pressing plate 608 is located in the cavity 6011 of the container pressing plate 601; a plurality of container pressing blocks 6081 are arranged on one surface of the soft pressing plate 608 facing the first loading plate 602 or the second loading plate 603, and the container pressing blocks 6081 are pressed on the container cover of the first container or the container cover of the second container; a plurality of positioning protrusions 6082 are arranged on the other surface of the soft pressing plate 608, a plurality of positioning holes 6012 are arranged on the inner surface of a cavity 6011 of the container pressing block 6081, and the positioning protrusions 6082 are inserted into the positioning holes 6012. In this embodiment, a total of 25 test tubes are arranged on the first loading plate 602, one side of the soft pressing plate 608 facing the first loading plate 602 is provided with the same number of container pressing blocks 6081, the positions of the container pressing blocks 6081 correspond to the positions of the test tubes one by one, the other side of the soft pressing plate 608 is provided with 9 positioning bumps 6082, an array of the 9 positioning bumps 6082 is distributed on the soft pressing plate 608, correspondingly, as shown in fig. 15, the inner surface of the cavity 6011 is correspondingly provided with 9 positioning holes 6012, when the container pressing plate 601 is covered on the first loading plate 602, the first loading plate 602 is located in the cavity 1 of the container pressing plate 601, and the position of the soft pressing plate 608 is prevented from being deviated through the matching of the positioning bumps 6082 and the positioning holes 6012, and the container pressing blocks 6081 on the soft pressing plate 608 is pressed on the test tube covers of the test tubes; when the container fixing frame 60 is fixed on the supporting seat 30, the locking device 40 realizes the fixation of the container fixing frame 60 by pressing the container pressing plate 601, the soft pressing plate 608 is made of a material with soft texture, and the pressing can be better performed on the test tube cover of the test tube, so that the test tube cover is prevented from being loosened.
As for the supporting seat 30, the invention provides a specific embodiment, as shown in fig. 16, the supporting seat 30 includes a transverse plate 303, a first vertical plate 301 and a second vertical plate 302, the first vertical plate 301 and the second vertical plate 302 are parallel, and both the first vertical plate 301 and the second vertical plate 302 are perpendicular to the transverse plate 303; the locking device 40 is installed on the first vertical plate 301, and the container holder 60 is installed between the first vertical plate 301 and the second vertical plate 302 through the locking device 40. A rib plate 304 is further arranged on one side of the second vertical plate 302 for reinforcing the strength of the second vertical plate 302, and the first vertical plate 301, the transverse plate 303, the second vertical plate 302 and the rib plate 304 are of an integrally formed structure.
As for the locking device 40, on the basis of any of the above embodiments, the invention provides a specific embodiment, as shown in fig. 17, the locking device 40 is fixed on the first vertical plate 301 of the support base 30, the locking device 40 includes a knob 401, a locking shaft 402 and a moving pressing block 403, wherein the knob 401 and the moving pressing block 403 are respectively located at two sides of the first vertical plate 301, the moving pressing block 403 is located at an inner side close to the second vertical plate 302, one end of the locking shaft 402 is fixedly connected with the knob 401, after the locking shaft 402 passes through the first vertical plate 301, the other end of the locking shaft 402 is in threaded connection with the moving pressing block 403, when the moving pressing block 403 is limited to be unable to rotate and can only move along the axial direction of the locking shaft 402, the moving pressing block 403 can move in the axial direction of the locking shaft 402 under the action of the knob 401, so as to adjust the distance between the moving pressing block 403 and the second vertical plate 302, after the container fixing frame 60 is inserted into the gap between the second vertical plate 302 and the first vertical plate 301, the container fixing frame 60 is fixed by pressing the movable pressing block 403 on the container fixing frame 60.
As for the locking device 40, on the basis of the above embodiments, as shown in fig. 17 to 19, the present invention further provides a specific embodiment, the locking device 40 further includes a fixed pressing block 404, the movable pressing block 403 and the fixed pressing block 404 are respectively located at two sides of the first vertical plate 301 of the supporting seat 30, and the fixed pressing block 404 is fixed on the first vertical plate 301; specifically, a protrusion 4041 is arranged on one side of the fixed pressing block 404 facing the first vertical plate 301, a through hole is arranged at the center of the protrusion 4041, and an internal thread is arranged in the through hole; a through hole is formed in the center of the movable pressing block 403, and an internal thread is formed in the through hole of the movable pressing block 403; be provided with the through-hole on the first vertical board 301 of supporting seat 30, when fixing briquetting 404 passes through the screw fixation on first vertical board 301, arch 4041 on the fixing briquetting 404 then stretches into in the through-hole of first vertical board 301, pass in the through-hole of fixing briquetting 404, the through-hole of first vertical board 301 and the through-hole of removal briquetting 403 of locking axle 402, and, locking axle 402 on be provided with first external screw thread and second external screw thread, and the direction of turning round of first external screw thread is opposite with the direction of turning round of second external screw thread, first external screw thread with fixing briquetting 404's internal thread phase-match, the second external screw thread with the internal thread phase-match of removal briquetting 403.
In addition, in the embodiment illustrated in fig. 17 to 19, the locking device 40 further includes a movable pressing plate 405, the movable pressing block 403 is provided with a protrusion protruding outward, the movable pressing plate 405 is correspondingly provided with a through hole, when the movable pressing plate 405 is fixed on the movable pressing block 403, the protrusion on the movable pressing block 403 is inserted into the through hole of the movable pressing plate 405, and the movable pressing plate 403 is driven by the locking shaft 402 to move, so as to drive the movable pressing plate 405 to move together. Further, in the above embodiment, the locking device 40 further includes a first positioning pin 406, the first pin hole is correspondingly formed in the first vertical plate 301 of the support plate and the moving pressing block 403, the first positioning pin 406 is inserted into the first pin hole of the moving pressing block 403 and the first vertical plate 301, when the moving pressing block 403 is driven by the locking shaft 402 to move, the first positioning pin 406 can prevent the moving pressing block 403 from rotating together with the locking shaft 402, so that the moving pressing block 403 can only reciprocate along the axial direction of the locking shaft 402.
As shown in fig. 19, the first external thread on the locking shaft 402 and the second external thread are opposite in rotation direction, and the movement of the moving pressing block 403, the locking shaft 402 and the fixed pressing block 404 forms the operation mode of the differential thread; when the first external thread is a right-handed thread and the second external thread is a left-handed thread, and the knob 401 is turned in the direction shown in fig. 19, the locking shaft 402 moves leftward relative to the fixed pressing block 404, and the movable pressing block 403 moves leftward relative to the locking shaft 402; when the knob 401 is rotated in the opposite direction as shown in fig. 19, the locking shaft 402 moves to the right with respect to the fixed pressing piece 404, and the moving pressing piece 403 moves to the right with respect to the locking shaft 402. When the first external thread is a left-hand thread and the second external thread is a right-hand thread, the locking shaft 402 moves rightward relative to the fixed pressing block 404 when the knob 401 is rotated in the direction shown in fig. 19, and the movable pressing block 403 moves rightward relative to the locking shaft 402; when the knob 401 is rotated in the reverse direction in fig. 19, the locking shaft 402 moves to the left with respect to the stationary pressing piece 404, and the moving pressing piece 403 moves to the left with respect to the locking shaft 402. By adjusting the position of the movable pressing block 403 in this way, the actual moving distance of the movable pressing block 403 is the sum of the lead of the first external thread and the lead of the second external thread, and the position of the movable pressing block 403 can be quickly adjusted. According to the invention, through the structure of the locking device 40, the adjustment of the positions of the movable pressing block 403 and the movable pressing plate 405 along the axial direction of the locking shaft 402 is realized, when the container fixing frame 60 needs to be fixed, the container fixing frame 60 is fixed between the first vertical plate 301 and the second vertical plate 302 of the supporting seat 30, and the movable pressing plate 405 is driven to be pressed on the container fixing frame 60 by rotating the knob 401; when the container fixing frame 60 needs to be taken out, the knob 401 is rotated reversely, and the movable pressing plate 405 is far away from the container fixing frame 60; the fixing mode of the container fixing frame 60 is simple, convenient and quick to operate, and the container fixing frame 60 can be quickly fixed.
On the premise of the above-mentioned embodiment of the locking device 40, a specific embodiment is provided for the container platen 601, as shown in fig. 14, a limiting groove 6013 is provided on the container platen 601, the width of the limiting groove 6013 is slightly greater than the width of the movable platen 405, and when the container fixing frame 60 is placed between the first vertical plate 301 and the second vertical plate 302, the movable platen 405 is accommodated in the limiting groove 6013 of the container platen 601; through the design of the limiting groove 6013 structure, when the container fixing frame 60 is placed between the first vertical plate 301 and the second vertical plate 302, the limiting groove 6013 and the movable pressing plate 405 are matched, so that the container fixing frame 60 can be limited in position, the container fixing frame 60 is located in the center of the transverse plate 303, and deviation of the position of the container fixing frame 60 is prevented.
As for the driving device 50, as shown in fig. 20, the driving device 50 includes a motor 501, a driving wheel 502, a crank 503, a guide 504 and a slide block 505, the guide 504 is fixedly installed on a fixing plate, the slide block 505 is slidably disposed on the guide 504, the fixing plate is provided with a groove for placing the guide 504 and the slide block 505, and the support seat 30 is fixed on the slide block 505; the motor 501 is used for driving the driving wheel 502 to rotate, one end of the crank 503 is rotatably connected to the driving wheel 502, one end of the crank 503 is driven to rotate around the central shaft through the driving wheel 502, and the other end of the crank 503 is rotatably connected to the supporting seat 30 so as to drive the supporting seat 30 to reciprocate on the guide rail 504.
Further, as shown in fig. 20, 21 and 22, the driving device further includes a fixing base 506, a first driving wheel 507, a driving belt 508, a second driving wheel 509 and a connecting shaft 510, the motor 501 is fixed on the fixing base 506, the first driving wheel 507 is fixed on the output shaft of the motor, the second driving wheel 508 is fixed at one end of the connecting shaft 510, and the other end of the connecting shaft 510 is fixedly connected with the driving wheel 502; the transmission belt 508 is sleeved on the first transmission wheel 507 and the second transmission wheel 509; in addition, the driving device 50 further includes a first bearing 514, a first bearing housing 515, a first bearing plate 516, a second bearing 517, a second bearing housing 518, and a second bearing plate 519; the first bearing plate 516 and the second bearing plate 519 are respectively fixed on the upper surface and the lower surface of the bearing support plate 513, a through hole is formed in the bearing support plate 513, the connecting shaft 509 passes through the first bearing 514 and the second bearing 517, the first bearing plate 516 fixes the first bearing 514 on the first bearing seat 515, and the second bearing plate 519 fixes the second bearing 517 on the second bearing seat 518.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (13)

1. A shock attenuation emulsion prepares appearance which characterized in that: comprises a fixed plate, a bottom plate, a pressure strip, a supporting seat, a driving device, a locking device and a container fixing frame;
the driving device is fixedly arranged on the fixing plate, the container fixing frame is arranged above the supporting seat through the locking device, and the driving device is used for driving the supporting seat to reciprocate on the fixing plate;
the pressing plate is arranged on the bottom plate, the fixed plate is positioned between the bottom plate and the pressing plate, and the pressing plate and the fixed plate as well as the fixed plate and the bottom plate are elastically connected;
the pressing plate is L-shaped and comprises a first vertical plate and a first limiting plate which are vertical to each other;
the first vertical plate is fixed on the bottom plate, the first limiting plate is located above the fixing plate, a first silica gel ball is arranged between the lower surface of the first limiting plate and the upper surface of the fixing plate, and a second silica gel ball is arranged between the lower surface of the fixing plate and the upper surface of the bottom plate.
2. The apparatus of claim 1, wherein: the lower surface of the first limiting plate and the upper surface of the fixing plate are both provided with spherical grooves used for accommodating the first silica gel balls.
3. The apparatus of claim 1, wherein: the lower surface of the fixing plate is provided with a fixing groove, a backing ring and a compression nut are arranged in the fixing groove, a mounting hole for mounting a second silica gel ball is formed in the compression nut, and the second silica gel ball protrudes out of the mounting hole; the backing ring is located on the top of the second silica gel ball.
4. The apparatus of claim 1, wherein: the bottom plate is square, and a pressure strip is fixed at each of four corners of the bottom plate.
5. The apparatus of claim 1, wherein: the container fixing frame comprises a container pressing plate, a first loading plate, a second loading plate and a plurality of supporting columns; the plurality of supporting columns are fixed between the first loading plate and the second loading plate; the first loading plate is provided with a plurality of first through holes for inserting first containers, and the second loading plate is provided with a plurality of second through holes for inserting second containers;
the container pressing plate is connected to the first loading plate or the second loading plate and used for pressing the container cover of the first container or the container cover of the second container.
6. The apparatus of claim 5, wherein: the container pressing plate is provided with a concave cavity, and the first loading plate or the second loading plate is positioned in the concave cavity of the container pressing plate.
7. The apparatus of claim 6, wherein: the container fixing frame also comprises a soft pressing plate, and the soft pressing plate is positioned in a concave cavity of the container pressing plate;
one surface of the soft pressure plate, which faces the first loading plate or the second loading plate, is provided with a plurality of container pressure blocks, and the container pressure blocks are tightly pressed on the container cover of the first container or the container cover of the second container;
the other side of the soft pressing plate is provided with a plurality of positioning lugs, the inner surface of the cavity of the pressing block is provided with a plurality of positioning holes, and the positioning lugs are inserted into the positioning holes.
8. The apparatus of claim 1, wherein: the supporting seat comprises a transverse plate, a first vertical plate and a second vertical plate, the first vertical plate and the second vertical plate are parallel, and the first vertical plate and the second vertical plate are both vertical to the transverse plate;
the locking device is arranged on the first vertical plate, and the container fixing frame is arranged between the first vertical plate and the second vertical plate through the locking device.
9. The apparatus of claim 7, wherein: the locking device comprises a knob, a locking shaft and a movable pressing block, one end of the locking shaft is fixedly connected with the knob, the other end of the locking shaft is in threaded connection with the movable pressing block, and the knob is used for driving the movable pressing block to be pressed on the container fixing frame through the locking shaft.
10. The apparatus of claim 9, wherein: the locking device further comprises a fixed pressing block, the movable pressing block and the fixed pressing block are respectively positioned on two sides of the first vertical plate of the supporting seat, and the fixed pressing block is fixed on the first vertical plate;
a through hole is formed in the center of the fixed pressing block, and an internal thread is arranged in the through hole of the fixed pressing block; a through hole is formed in the center of the movable pressing block, and an internal thread is formed in the through hole of the movable pressing block; a through hole is formed in the first vertical plate of the supporting seat, and the locking shaft penetrates through the through hole of the fixed pressing block, the through hole of the first vertical plate and the through hole of the movable pressing block;
the locking shaft is provided with a first external thread and a second external thread, the turning direction of the first external thread is opposite to that of the second external thread, the first external thread is matched with the internal thread of the fixed pressing block, and the second external thread is matched with the internal thread of the movable pressing block;
the locking device further comprises a first positioning pin, the first vertical plate of the movable pressing block and the support plate is correspondingly provided with a first pin hole, and the first positioning pin is inserted into the first pin holes of the movable pressing block and the first vertical plate to prevent the movable pressing block from rotating together with the locking shaft.
11. The apparatus of claim 10, wherein: the locking device also comprises a movable pressing plate, the movable pressing plate is fixed on the movable pressing block, and the movable pressing plate is used for pressing the container fixing frame;
the container pressing plate is provided with a limiting groove, and when the container fixing frame is placed between the first vertical plate and the second vertical plate, the movable pressing plate is accommodated in the limiting groove of the container pressing plate.
12. The apparatus of claim 1, wherein: the driving device comprises a motor, a driving wheel, a crank, a guide rail and a sliding block;
the guide rail is fixedly arranged on the fixed plate, the sliding block is arranged on the guide rail in a sliding manner, and the supporting seat is fixed on the sliding block;
the motor be used for driving the drive wheel and rotate, the one end of crank is rotated and is connected on the drive wheel, drives the one end of crank through the drive wheel and rotates around the center pin, the other end of crank rotates and is connected to on the supporting seat to drive supporting seat reciprocating motion on the guide rail.
13. The apparatus of claim 12, wherein: the driving device also comprises a first driving wheel, a driving belt, a second driving wheel and a connecting shaft; the first driving wheel is fixed on the output shaft of the motor, the second driving wheel is fixed at one end of the connecting shaft, and the other end of the connecting shaft is fixedly connected with the driving wheel; the transmission belt is sleeved on the first transmission wheel and the second transmission wheel.
CN201710321898.6A 2017-05-09 2017-05-09 Shock-absorbing emulsion preparation instrument Active CN108854763B (en)

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DE102006011370A1 (en) * 2006-03-09 2007-09-20 Eppendorf Ag Device for mixing, in particular, laboratory vessel contents with a sensor
DE202006003820U1 (en) * 2006-03-10 2006-05-11 Eppendorf Ag Mixing device for laboratory vessel, micro-titer plates, slides and/or other sample carriers comprises housing, support for sample carrier, drive driving support, keyboard, electrical control unit and voltage supply
CN201171972Y (en) * 2008-01-14 2008-12-31 深圳市海川实业股份有限公司 Antivibration mounting mechanism for liquid material swing type mixing device
CN104722232B (en) * 2013-12-24 2017-03-15 广州万孚生物技术股份有限公司 One kind rotates the disk that shakes
CN203790860U (en) * 2014-05-01 2014-08-27 铜陵钱谊化工设备有限责任公司 Stirring machine with damping device
CN106311049A (en) * 2016-10-17 2017-01-11 无锡市日升化工有限公司 Chemical material mixing machine with damping function

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