CN108853149A - A kind of Chemical composition that paste and its preparation method and application with molten first effect - Google Patents
A kind of Chemical composition that paste and its preparation method and application with molten first effect Download PDFInfo
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- CN108853149A CN108853149A CN201811145480.5A CN201811145480A CN108853149A CN 108853149 A CN108853149 A CN 108853149A CN 201811145480 A CN201811145480 A CN 201811145480A CN 108853149 A CN108853149 A CN 108853149A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention discloses a kind of Chemical composition that paste and its preparation method and application with molten first effect.The Chemical composition that paste is made of each raw material of following parts by weight：Urea 10-500 parts by weight, vaseline 10-500 parts by weight, lanolin 10-500 parts by weight, beeswax 10-500 parts by weight, borneol 1-50 parts by weight and chlorhexidine acetate 1-5 parts by weight.The preparation method includes that urea, chlorhexidine acetate, borneol pulverize and sieve, weigh, and is made with the vaseline, lanolin, beeswax weighed through the production craft step of thawing, stirring, homogeneous, vacuum outgas, packing.It is demonstrated experimentally that Chemical composition that paste of the invention has molten first effect, it can be achieved that cutin-softening keeps deck thinning, removes the grain generated on deck and mince matter, be more advantageous to the infiltration for the treatment of onychomycosis drug, acted on so that therapeutic agent be made to play preferable curative effect.
Description
Technical field
The present invention relates to a kind of Chemical composition that paste, in particular to a kind of Chemical composition that paste with molten first effect
And its preparation method and application.
Background technique
Onychomycosis is commonly called as " onychomycosis ", refers to that dermatophytes invades disease caused under deck or first, is that one kind betides finger
Nosomycosis under (toe) first and first.The pathomycete of this disease is caused to have dermatophyte, yeast and yeast-like fungus and candida albicans etc., it
Caused by first portion damage slightly have difference, be clinically referred to as onychomycosis.Onychomycosis is most obstinate refractory one kind in dermatophytosis.
Orally available, external drug, or operation are pulled out first and are treated.
The nail that first is suitable for single-shot is pulled out in operation, will suffer from first under local anaesthesia and pulls out.This method surface of a wound is big, bleeding is more, Yi Yin
Infection is played, can generally feel to be easy to re-infect recurrence, clinical less use, and heart disease, high blood compared with pain after operation
This unsuitable operative treatment of the patients such as pressure, diabetes.Oral antifungal agents object has certain curative effect, convenient and simple.But because of such medicine
Object must reach competence exertion antibacterial action at the parasitic deck of fungi, and solubility in water is lower, dissolution is relatively slow,
Absorption And Metabolism quickly, so dosage is big, administration time is long, easily causes normal flora imbalance.Oral medicine is also possible to generate secondary
Effect, such as serious damage liver kidney, and it is easy to recur after drug withdrawal, therefore should not be as the conventional treatment drug of onychomycosis.Topical therapy
According to medicament difference, it is broadly divided into local application and package is cut and the methods of controlled.Since onychomycosis is fungi sense caused by nail matrix
Dye, general outer coating is difficult infiltration nail matrix and thoroughly kills germ, and treatment time is long, Chang Yinwei patient can not check for a long time and in
Way is abandoned, and onychomycosis can develop drug resistance make troubles for anaphase instead over time, and easy to recur, and externally applied drug exists in addition
Great inconvenience is caused to daily life in therapeutic process, though outer coating has certain help, pole to the consolidation in treatment later period
Few patient depends merely on outer coating and cures onychomycosis.
A kind of Chemical composition that paste with molten first effect of the invention, main component include urea, chlorhexidine acetate,
Vaseline (albolene), lanolin, beeswax, borneol (borneolum syntheticum).Chlorhexidine acetate has a broad antifungal spectrum, to most Gram-positives
And negative bacteria has killing effect, it is also effective to Pseudomonas aeruginosa.Urea is soluble easily in water, and proteolytic and change can be made by having
Property, increase the aquation of protein, so that cutin-softening, keeps deck thinning, removing the grain generated on deck minces matter, more has
Conducive to the infiltration for the treatment of onychomycosis drug, so that therapeutic agent be made to play preferable curative effect effect.Product of the present invention lotion stiff, property
The phenomenon that shape is stablized, and is not influenced and caused the change of character by seasonal temperature variation, and anhydrous formulations will not generate water-oil separating, keeps away
Having exempted from deck has inflammatory patients to use rear generation pain, the generation for the adverse reactions such as be not easy to heal.Product of the present invention has good
Application prospect.
Summary of the invention
The purpose of the present invention is to provide a kind of Chemical composition that paste with molten first effect and preparation method thereof and answer
With.
In order to achieve the above object, present invention employs following technological means：
A kind of Chemical composition that paste with molten first effect of the invention, is made of each raw material of following parts by weight：Urine
Plain 10-500 parts by weight, vaseline 10-500 parts by weight, lanolin 10-500 parts by weight, beeswax 10-500 parts by weight, borneol 1-50
Parts by weight and chlorhexidine acetate 1-5 parts by weight.
Wherein, it is preferred that the Chemical composition that paste is made of each raw material of following parts by weight：400 weight of urea
Part, 340 parts by weight of vaseline, 190 parts by weight of lanolin, 60 parts by weight of beeswax, 3 weight of 7 parts by weight of borneol and chlorhexidine acetate
Part.
Wherein, it is preferred that the beeswax is cera alba.
Wherein, it is preferred that the Chemical composition that paste is prepared by the following method to obtain：Urea, chlorhexidine acetate,
Borneol pulverizes and sieves, and weighs, and with the vaseline, lanolin and beeswax weighed, through thawing, stirring, homogeneous, vacuum outgas, divides
The production stage of dress is made.
Further, the invention also provides a kind of sides for preparing the Chemical composition that paste with molten first effect
Method includes the following steps：
(1) urea, chlorhexidine acetate, borneol pulverize and sieve, and weigh each raw material according to parts by weight of the present invention；
(2) weighed urea, chlorhexidine acetate, borneol, vaseline, lanolin, beeswax are added in tank body and melt, stirs
It mixes, homogeneous；
(3) material after stirring homogeneous carries out vacuum outgas, keeps material in certain temperature, packing to get.
Specifically, including the following steps：
(1) it pulverizes and sieves：Chlorhexidine acetate, borneol, urea be crushed into 200 meshes respectively, according to of the present invention
Parts by weight weigh each raw material；
(2) it melts, stir, homogeneous：Beeswax, vaseline, the lanolin weighed puts into the tank body that temperature is set as 85 ± 5 DEG C
In, stirring is opened, is stirred 10 minutes after fusing, emulsifying tank is transferred to and continues stirring, homogeneous, be cooled to 40 DEG C of set temperature
Continue stirring, homogeneous 10 minutes, add to urea in emulsion tank by a small amount of multiple method, operation is slow to open emulsion tank every time
It is slow that urea stirring, homogeneous is added, recycle this process；It is subsequent that chlorhexidine acetate, borneol is added while urea is added in last time
Continuous stirring, homogeneous；
(3) vacuum outgas：Material vacuum after stirring, homogeneous deaerates 30 minutes, is kept for 45 ± 5 DEG C of temperature of charge, dispenses,
To obtain the final product.
Further, the invention also provides the Chemical composition that paste has the product of molten first effect in preparation
In purposes.
Wherein, it is preferred that the product with molten first effect have cutin-softening make deck it is thinning, removal deck on
The grain of generation minces the effect of matter, the infiltration for the treatment of onychomycosis drug is more advantageous to, to play preferable curative effect.
Specific embodiment
The present invention is further described below by testing in conjunction with specific embodiments, examples are merely exemplary for these,
It is not intended to limit the scope of the present invention in any way.It will be understood by those skilled in the art that without departing from essence of the invention
Can be with the details and forms of the technical scheme of the invention are modified or replaced under mind and range, but these modifications and replacement are fallen
Enter in protection scope of the present invention.
There is embodiment 1 the Chemical composition that paste of molten first effect to prepare
(1) each material composition is weighed by following weight：400 grams of urea, 340 grams of vaseline (albolene), lanolin 190
Gram, 60 grams of beeswax (white), 7 grams of borneol (borneolum syntheticum), 3 grams of chlorhexidine acetate.
(2) production technology
A, it pulverizes and sieves：Chlorhexidine acetate, borneol (borneolum syntheticum), urea be crushed into 200 meshes, claimed by formula ratio
Weight, it is spare.
B, fusing, stirring, homogeneous：Beeswax (white), vaseline (albolene), the lanolin weighed puts into temperature and is set as
In 85 ± 5 DEG C of tank body, stirring is opened, is stirred 10 minutes after fusing, is transferred to emulsifying tank and continue stirring, homogeneous, cooling
Continue stirring, homogeneous 10 minutes to 40 DEG C of set temperature.Urea is added in emulsion tank by a small amount of multiple method, is operated every time
It is slowly added to urea stirring, homogeneous to open emulsion tank, recycles this process；Acetic acid chlorine is added while urea is added in last time
Continue stirring, homogeneous after oneself fixed, borneol (borneolum syntheticum)
C, vacuum outgas：Material vacuum after stirring, homogeneous deaerates 30 minutes, is kept for 45 ± 5 DEG C of temperature of charge, dispenses,
To obtain the final product.
There is embodiment 2 the Chemical composition that paste of molten first effect to prepare
(1) each material composition is weighed by following weight：400 grams of urea, 340 grams of vaseline (albolene), lanolin 190
Gram, 60 grams of beeswax (white), 7 grams of borneol, 3 grams of chlorhexidine acetate.
(2) production technology
A, it pulverizes and sieves：Chlorhexidine acetate, borneol (borneolum syntheticum), urea be crushed into 200 meshes, claimed by formula ratio
Weight, it is spare.
B, fusing, stirring, homogeneous：(white) investment of beeswax, which is set in 60-100 DEG C of tank body to temperature, makes its fusing, then
Vaseline (albolene), lanolin are sequentially added, is stirred 10-60 minutes after fusing, is transferred to emulsifying tank.Cool down to material
Chlorhexidine acetate is added after to 30-80 DEG C, stirring, homogeneous each 10 minutes repeat this operation twice.It will by a small amount of multiple method
Urea adds in emulsion tank, and operation is slowly added to urea stirring, homogeneous to open emulsion tank every time, recycles this process；Urea is complete
Portion puts into borneol (borneolum syntheticum) after being added again, continues stirring, the total operation of homogeneous 120 minutes.
C, vacuum outgas：Stirring, the material vacuum degassing after homogeneous, are kept for 45 DEG C of temperature of charge, packing to get.
There is embodiment 3 the Chemical composition that paste of molten first effect to prepare
(1) each material composition is weighed by following weight：400 grams of urea, 340 grams of vaseline (albolene), lanolin 190
Gram, 60 grams of beeswax (white), 7 grams of borneol, 3 grams of chlorhexidine acetate.
(2) production technology
A, it pulverizes and sieves：Chlorhexidine acetate, borneol (borneolum syntheticum), urea be crushed into 200 meshes, claimed by formula ratio
Weight, it is spare.
B, fusing, stirring, homogeneous：(white) investment of beeswax, which is set in 80-85 DEG C of tank body to temperature, makes its fusing, then according to
Secondary addition vaseline (albolene), lanolin stir 30 minutes after fusing, are transferred to emulsifying tank.40- is cooled to material
Urea is added in emulsion tank by a small amount of multiple method after 45 DEG C, each operation is slowly added to urea for unlatching emulsion tank and stirs
It mixes, homogeneous, recycles this process；Urea all be added after be added chlorhexidine acetate, borneol (borneolum syntheticum) stir 30 minutes it is subsequent
Continuous stirring, homogeneous operation, every time stirring, homogeneous each 10 minutes amount to operation 150 minutes.
C, vacuum outgas：Stirring, the material vacuum degassing after homogeneous, are kept for 45 DEG C of temperature of charge, packing to get.
There is comparative example 1 the Chemical composition that paste of molten first effect to prepare
(1) each material composition is weighed by following weight：400 grams of urea, 110 grams of vaseline (albolene), 80 grams of stearic acid,
50 grams of stearine, 50 grams of glycerol, 30 grams of polyoxyethylene sorbitan monoleate, 1 gram of ethyl hydroxy benzoate, Purified Water q. s.
(2) production technology
A, it weighs：By urea, vaseline (albolene, stearic acid, stearine, glycerol, polyoxyethylene sorbitan monoleate, oxybenzene
Ethyl ester is weighed by formula ratio, spare.
B, fusing, stirring：It weighs in appropriate purified water investment water phase tank, glycerol, polyoxyethylene sorbitan monoleate, urea to temperature is added
It is set in 80 ± 5 DEG C of tank body and makes it dissolve, stir, heat preservation.Vaseline (albolene) addition temperature is set in 80 ± 5 DEG C
Oily phase tank in, stearic acid, stearine, ethyl hydroxy benzoate stirring and dissolving are sequentially added after fusing, keep the temperature.
C, mixing, homogeneous, vacuum outgas：The material in water phase tank, oily phase tank is pumped into homogeneous emulsifying machine with vacuum, is opened
Open homogeneous stirring.Vacuum outgas, packing to get.
There is comparative example 2 the Chemical composition that paste of molten first effect to prepare
(1) each material composition is weighed by following weight：380 grams of urea, 150 grams of vaseline (albolene), stearic acid 100
Gram, 60 grams of stearine, 50 grams of glycerol, 50 grams of polyoxyethylene sorbitan monoleate, 2 grams of ethyl hydroxy benzoate, Purified Water q. s.
(2) production technology
A, it weighs：By urea, vaseline (albolene, stearic acid, stearine, glycerol, polyoxyethylene sorbitan monoleate, oxybenzene
Ethyl ester is weighed by formula ratio, spare.
B, fusing, stirring：It weighs in appropriate purified water investment water phase tank, glycerol, polyoxyethylene sorbitan monoleate, urea to temperature is added
It is set in 80 ± 5 DEG C of tank body and makes it dissolve, stir, heat preservation.Vaseline (albolene) addition temperature is set in 80 ± 5 DEG C
Oily phase tank in, stearic acid, stearine, ethyl hydroxy benzoate stirring and dissolving are sequentially added after fusing, keep the temperature.
C, mixing, homogeneous, vacuum outgas：The material in water phase tank, oily phase tank is pumped into homogeneous emulsifying machine with vacuum, is opened
Open homogeneous stirring.Vacuum outgas, packing to get.
The determination of 1 Recipe of experimental example
Test one
It is respectively adopted that embodiment 1, comparative example 1, production technology is compared in comparative example 2, by embodiment 1, comparison
Example 1, comparative example 2 prepare the several respects such as matter state, characteristic trait and the formula components of resulting composition paste, feature and are compared
Compared with comparing result statistics is shown in Table 1.
1 embodiment of table examines comparison statistical form
Conclusion：By the matter state, pH value, property that prepare products obtained therefrom to embodiment 1, comparative example 1,2 production technology of comparative example
Shape feature and formula components, characteristic comparing, obtain：Matter state, the pH value that product is made in the anhydrous formulations technique that embodiment 1 uses are equal
It meets the requirements, and character is stablized, lotion stiff is more in line with market sale demand.
Test two
The patient that 60 clinical manifestations are onychomycosis is chosen, it is good to be selected in patient's general health.It is randomly divided into tri- groups of ABC
(wherein having following situations, person is not selected in：Once antifungal was taken in three months；There is immunity disease or takes immunosuppressor person；
There are obvious systemic disease and hepatic renal dysfunction person；There are bleeding, blood coagulation disorders person；Gestation and lactation person).A, tri- component of B, C
Coating encapsulating treatment Shi Yong not be carried out by Chemical composition that paste (the preparation method is the same as that of Example 1) made from corresponding formula in table 2,
The course for the treatment of 4 weeks.Method is as follows：
Coating encapsulating is carried out to affected part using composition paste, is first impregnated 30 minutes with warm water before coating, then cleans first
Plate, coating paste on deck in encapsulating 24 hours.Replacement in every 24 hours is primary.It is onychomycosis to 60 clinical manifestations after the course for the treatment of
Patient carry out questionnaire survey statistics, investigation content is to refer to (toe) onychomalacia degree, whether remove deck grain and mince matter.Evaluation mark
It is quasi-：It is smooth completely obvious for effect that deck pine plays nail matrix face after substance under good, first is macerated, removes first；There is object under pine, first on deck
Matter macerates, is that effect is more apparent except occasionally there is injustice in nail matrix face but remains without hard cutin after first；Deck pine rise bad, first under substance not
It is soft, nail matrix is uneven, there have to be soft or hard horn residual be considered as to no effect.Questionnaire statistical result is shown in Table 3.
Tri- groups of composition therefor paste ingredient ingredients of table 2 A, B, C
3 Questionnaire results statistical form of table
Conclusion：By being randomly divided into three groups to the patient that 60 clinical manifestations are onychomycosis, respectively using formula corresponding in table 2
After the certain course for the treatment of of Chemical composition that paste obtained Questionnaire results comparison, obtain, A group of formula (containing chlorhexidine acetate at
Point) made from Chemical composition that paste using effect better than B group (be free of chlorhexidine acetate ingredient) and C group (without urea at
Point) formula using effect.
Compbined test one, test two the data obtaineds comparison, choose the formula of embodiment 1 as optimization formula.
The determination of 2 technological process of production of experimental example
The technological process of production of embodiment 1, embodiment 2, embodiment 3 has been respectively adopted in the present invention, to various processes
The embodiment of process is sampled inspection, and inspection project is color, matter state, pH value, heat-resisting cold-resistant, chlorhexidine acetate.
1. chlorhexidine acetate measures
A, measuring method
Precision weighs this product in right amount (being approximately equivalent to chlorhexidine acetate 10mg), sets in separatory funnel, adds tepor chloroform
30ml, shaking make stromatolysis, extract 5 times (20ml, 20ml, 15ml, 15ml, 15ml) with 1.5mol/L acetum, merge
Acid solution is diluted to scale in 100ml measuring bottle, with 1.5mol/L acetum, shakes up, and precision measures 5ml, sets in 50ml measuring bottle,
Add ethyl alcohol to be diluted to scale, shake up, according to UV-VIS spectrophotometry (general rule 0401), extinction is measured at the wavelength of 260nm
Degree.Chlorhexidine acetate reference substance about 10mg separately is taken, it is accurately weighed, it sets in 100ml measuring bottle, adds the dissolution of 1.5mol/L acetum simultaneously
It is diluted to scale, is shaken up.Precision measure 5ml, set in 50ml measuring bottle, be diluted to scale with ethyl alcohol, be measured in the same method, calculate to get.
B, calculation formula：Cx=(Ax/AR) CR
Wherein Cx：The concentration of test solution
Ax：The absorbance of test solution
CR：The concentration of reference substance solution
AR：The absorbance of reference substance solution
2. other inspection projects are shown in Table 4
4 embodiment of table examines project statistical form
Conclusion：By the technological process of production to embodiment 1, embodiment 2, embodiment 3 be made the color of paste, matter state,
Heat-resisting cold-resistant, chlorhexidine acetate, pH value measurement result are compared, and are obtained：The chlorhexidine acetate that embodiment 1 measures contains
Amount, pH value are better than embodiment 2, embodiment 3, and color, matter state, heat-resisting cold-resistant Xiang Jun meet the requirements, therefore choose embodiment 1
Production technology.
Experimental example 3：The molten first of product of the present invention is tested and molten first curative effect questionnaire survey statistics
1. testing data
Selection clinical manifestation is patient 42 of onychomycosis (color and paramophia of first), and (there were following feelings at 20-55 years old age
Condition person is not selected in：Once antifungal was taken in three months；There is immunity disease or takes immunosuppressor person；There is obvious systemic disease
Disease and hepatic renal dysfunction person；There are bleeding, blood coagulation disorders person；Gestation and lactation person).
2. test method
Coating encapsulating is carried out to affected part using paste prepared by embodiment 1 to the patient that 42 clinical manifestations are onychomycosis.It applies
It is first impregnated 30 minutes with warm water before applying, then cleans deck.On paste application deck prepared by embodiment 1 and encapsulating 24 is small
When, replacement in every 24 hours is primary, and the course for the treatment of 4 weeks.When replacing the composition paste for applying disease first every time, it is proposed that most with nail clipper
Amount, which cuts sick first, rasps away, and cleans deck, then encapsulates again.42 onychomycosis are prepared using embodiment 1 after the course for the treatment of
Curative effect after paste carries out questionnaire survey, and survey item is to refer to (toe) onychomalacia degree, whether remove deck grain and mince matter.
Evaluation criteria：It is smooth completely obvious for effect that deck pine plays nail matrix face after substance under good, first is macerated, removes first；First
Plate has pine to rise, substance is macerated, is that effect is more apparent except occasionally there is injustice in nail matrix face but remains without hard cutin after first under first；Deck pine rises
Substance is not soft under bad, first, nail matrix is uneven, there have to be soft or hard horn residual is considered as to no effect.
3. result
Questionnaire results statistics is shown in Table 5.
5 curative effect Questionnaire results statistical form of table
By being asked using the curative effect investigation after the present composition according to method the patient that 42 clinical manifestations are onychomycosis
Clove hitch fruit is counted, and is obtained：42 clinical manifestations are that the patient of onychomycosis uses finger (toe) onychomalacia journey after the present composition
Degree has an improvement, and the grain matter that minces in deck has removal effect, illustrates that the present composition has molten first effect, can remove deck
The grain of upper generation minces matter, is more advantageous to the infiltration for the treatment of onychomycosis drug.To make therapeutic agent play preferable curative effect effect.
Claims (8)
1. a kind of Chemical composition that paste with molten first effect, it is characterised in that be made of each raw material of following parts by weight：Urine
Plain 10-500 parts by weight, vaseline 10-500 parts by weight, lanolin 10-500 parts by weight, beeswax 10-500 parts by weight, borneol 1-50
Parts by weight and chlorhexidine acetate 1-5 parts by weight.
2. Chemical composition that paste as described in claim 1, it is characterised in that be made of each raw material of following parts by weight：Urea
400 parts by weight, 340 parts by weight of vaseline, 190 parts by weight of lanolin, 60 parts by weight of beeswax, 7 parts by weight of borneol and acetic acid chlorine oneself
Fixed 3 parts by weight.
3. Chemical composition that paste as claimed in claim 1 or 2, it is characterised in that the beeswax is cera alba.
4. Chemical composition that paste as described in any one of claims 1-3, which is characterized in that the Chemical composition that paste
It is prepared by the following method to obtain：Urea, chlorhexidine acetate, borneol pulverize and sieve, and weigh, with vaseline, the lanolin weighed
And beeswax, the production stage through thawing, stirring, homogeneous, vacuum outgas, packing are made.
5. a kind of method for preparing the described in any item Chemical composition that paste with molten first effect of claim 1-4, special
Sign is to include the following steps：
(1) urea, chlorhexidine acetate, borneol pulverize and sieve, and parts by weight according to claim 1 or 2 weigh each raw material；
(2) weighed urea, chlorhexidine acetate, borneol, vaseline, lanolin, beeswax are added in tank body and melt, stirs,
Matter；
(3) material after stirring homogeneous carries out vacuum outgas, keeps material in certain temperature, packing to get.
6. method as claimed in claim 5, it is characterised in that include the following steps：
(1) it pulverizes and sieves：Chlorhexidine acetate, borneol, urea be crushed into 200 meshes respectively, according to as claimed in claim 1 or 2
Parts by weight weigh each raw material；
(2) it melts, stir, homogeneous：The beeswax that has weighed, vaseline, lanolin investment temperature are set as in 85 ± 5 DEG C of tank body,
Open stirring, stir 10 minutes after fusing, be transferred to emulsifying tank continue to stir, homogeneous, be cooled to 40 DEG C of set temperature after
Continuous stirring, homogeneous 10 minutes are added to urea in emulsion tank by a small amount of multiple method, and operation is slow to open emulsion tank every time
Urea stirring, homogeneous is added, recycles this process；Continue after chlorhexidine acetate, borneol is added while urea is added in last time
Stirring, homogeneous；
(3) vacuum outgas：Material vacuum after stirring, homogeneous deaerates 30 minutes, is kept for 45 ± 5 DEG C of temperature of charge, dispenses, i.e.,
?.
7. use of the Chemical composition that paste according to any one of claims 1-4 in the product that preparation has molten first effect
On the way.
8. purposes as claimed in claim 7, it is characterised in that the product with molten first effect makes with cutin-softening
The grain that deck is thinning, generates on removal deck minces the effect of matter.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3911306A4 (en) * | 2019-01-16 | 2022-08-10 | Global Health Solutions, LLC | Petrolatum-based phmb compositions and methods of treatment for onychomycosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105124A (en) * | 2008-08-01 | 2011-06-22 | 皮埃尔·法布尔皮肤化妆品公司 | Kit for the treatment of onychomycosis |
-
2018
- 2018-09-29 CN CN201811145480.5A patent/CN108853149A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105124A (en) * | 2008-08-01 | 2011-06-22 | 皮埃尔·法布尔皮肤化妆品公司 | Kit for the treatment of onychomycosis |
Non-Patent Citations (1)
| Title |
|---|
| 李桂明: "指甲营养不良使用尿素软膏剥离", 《国外医学.皮肤病学分册》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3911306A4 (en) * | 2019-01-16 | 2022-08-10 | Global Health Solutions, LLC | Petrolatum-based phmb compositions and methods of treatment for onychomycosis |
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Effective date of registration: 20200713 Address after: Room 303, building A3, Lanxi small and medium sized enterprise Industrial Park, Lanxi County, Suihua City, Heilongjiang Province Applicant after: Heilongjiang Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |
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Application publication date: 20181123 |