CN108852449A - A kind of vascular occlusion device and hemostatic system - Google Patents
A kind of vascular occlusion device and hemostatic system Download PDFInfo
- Publication number
- CN108852449A CN108852449A CN201810747066.5A CN201810747066A CN108852449A CN 108852449 A CN108852449 A CN 108852449A CN 201810747066 A CN201810747066 A CN 201810747066A CN 108852449 A CN108852449 A CN 108852449A
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- Prior art keywords
- vascular occlusion
- occlusion device
- ontology
- supporter frame
- sealing film
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- 206010053648 Vascular occlusion Diseases 0.000 title claims abstract description 51
- 208000021331 vascular occlusion disease Diseases 0.000 title claims abstract description 51
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 14
- 238000007789 sealing Methods 0.000 claims abstract description 35
- 239000000463 material Substances 0.000 claims description 25
- 210000004204 blood vessel Anatomy 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 16
- 229920000954 Polyglycolide Polymers 0.000 claims description 10
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 7
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 7
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 6
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 239000004626 polylactic acid Substances 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 239000004633 polyglycolic acid Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000003466 welding Methods 0.000 claims description 4
- 241001494479 Pecora Species 0.000 claims description 3
- 210000000936 intestine Anatomy 0.000 claims description 3
- 238000013021 overheating Methods 0.000 claims description 3
- VSKXVGWORBZZDY-UHFFFAOYSA-N 2-hydroxypropanoic acid;oxepan-2-one Chemical compound CC(O)C(O)=O.O=C1CCCCCO1 VSKXVGWORBZZDY-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 abstract description 9
- 230000000025 haemostatic effect Effects 0.000 description 11
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 229940030225 antihemorrhagics Drugs 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 210000001367 artery Anatomy 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 229920002643 polyglutamic acid Polymers 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 238000013153 catheter ablation Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 230000003446 memory effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention provides a kind of vascular occlusion devices, including supporter frame and sealing film, the supporter frame includes ontology and rock-steady structure, the edge of the ontology is convexly equipped with multiple rock-steady structures being oppositely arranged, the center position of the ontology is provided with intermediate structure, and the sealing film is laid on the outer surface of the supporter frame；Wherein, the ontology includes multiple pull rings and multiple bracing wires, and the pull ring is set to the edge of the ontology, and a bracing wire is connected to two pull rings being oppositely arranged；The present invention also provides a kind of hemostatic systems；Vascular occlusion device provided by the invention reduces operating time, improves surgical hemostasis difficulty and complexity so that can effectively reach hemostasis purpose in intervention operation.
Description
Technical field
The invention belongs to medical instruments field, it is related to a kind of vascular occlusion device and hemostatic system more particularly to a kind of warp
Skin major diameter vascular occlusion device and hemostatic system.
Background technique
In recent years, with the progress of interventional therapeutic technique, such as through catheter heart valves displacement or prosthetic, aorta pectoralis
Tumor prosthetic or cardiac ablation art etc. need to be inserted into conduit by the notch in patient skin and following tissue to enter
Artery or vein are performed the operation.Need to remove in conduit blood vessel after operation, therefore the blood vessel notch for being inserted into conduit must close
It closes.Since the blood pressure in artery is higher, the time that the methods of conventional pressing, suture, adhesive carry out hemostasis consuming is long, also holds
Easily cause unnecessary blood vessel distortion, and is extremely difficult to good sealing effect.
CN104394776A discloses a kind of vascular occlusion device comprising：Deployable braced frame can be deployed in arteries and veins
In pipe；Film is sealed, is at least partly supported by the braced frame；And cross member supports part, it extends across described close
At least part of sealer；Wherein, after the braced frame is unfolded, described device is configured to the sealing film being close to institute
State the perforation intracavitary placement in site present in blood vessel wall；And wherein the cross member supports part includes flexible wire, described to scratch
Property line be partially attached to the sealing film and being configured to therebetween the sealing film maintained to be close to the perforation site, this
The vascular occlusion device provided is provided, lacks and the structure of overall stability is provided, and it is small to seal film contact area, is unfavorable for reaching
To higher stability and better haemostatic effect.
A kind of method that CN105307575A discloses vascular occlusion device and positions vascular occlusion device comprising have
The sheath 10 of distal end and at least one proximal end, wherein the sheath 10 includes tubular body 100, at least one distal side balloon member 11
It is securely arranged in the far-end of the tubular body 100 of the sheath 10, and at least one inflatable anchorage element 12
It is securely arranged on the tubular body of the sheath 10, the nearside of the distal side balloon member 11, wherein at least described distal side
The distal side of balloon member 11 is for applying stressed pressure span on the outside of the vascular wall.Blood vessel disclosed in the method closes
It attaches together and sets complexity, and overall stability is not high, blood clotting effect is poor.
CN108135594A discloses a kind of vascular occlusion device, and the vascular occlusion device includes：Elongate housing, it is described
Elongate housing has proximally and distally, and the distal end is suitable for close to the tissue；First engagement member and the second engagement member, institute
It states the first engagement member and the second engagement member is releasably arranged in the elongate housing；Component, the exhibition is unfolded
It opens component and is arranged in the elongate housing, and the expansion component is suitable for first engagement member and second engagement
Structural member development is not engaged with the tissue Bonding contact with the wall portion of the blood vessel at being spaced each other at a distance；And contracting
Component is returned, the retraction component is arranged in the elongate housing and is suitable for reducing first engagement member and connects with described second
The distance between component is closed to be closed the access.Structure is complicated for the vascular occlusion device that the method provides, and when application is more numerous
It is trivial, it is unfavorable in emergency circumstances stopping blooding.
Existing interventional therapeutic technique postoperation hemostatic there are aiming at the problem that, need to develop a kind of novel vessel sealing
Device, to achieve the effect that quick-acting haemostatic powder, stability are high and degradable.
Summary of the invention
The purpose of the present invention is to provide a kind of vascular occlusion device and hemostatic systems, stop after having solved existing intervention operation
The blood vessel incision hemostasis time existing for blood process is long, is easy to the problems such as causing blood vessel distortion.
In order to achieve that object of the invention, the present invention uses following technical scheme：
In a first aspect, the present invention provides a kind of vascular occlusion device, including supporter frame and sealing film, the support
Body frame includes ontology and rock-steady structure, and the edge of the ontology is convexly equipped with multiple rock-steady structures being oppositely arranged, the ontology
Center position be provided with intermediate structure, the sealing film is laid on the outer surface of the supporter frame.
Vascular occlusion device provided by the invention, by being provided with rock-steady structure around supporter frame, so that device
There is higher stability, and intermediate structure is provided with by heart position in the body, so that sealing the contact surface of film
Product is bigger, further improves stability and haemostatic effect, and sealing intermediate shape after membrane degradation can mention for operation next time
For basis.It since the effect of sealing film is capable of forming thrombus, prevents blood from flowing out, to achieve the purpose that quick-acting haemostatic powder, reduces
Operating time improves surgical hemostasis difficulty and complexity.
In the present invention, the contact area of the part at rock-steady structure center and sealing film is more, bracket and sealing membrane support
Attachment force is stronger, can be more stable in the arteries of high pressure, when planar development, has the structure similar to helix exterior feature,
Hollow out and it is connected with ontology among rock-steady structure.
Preferably, the ontology includes multiple pull rings and multiple bracing wires, and the pull ring is set to the edge of the ontology,
A piece bracing wire is connected to two pull rings being oppositely arranged.
Preferably, the vascular occlusion device forms globoidal structure through Overheating Treatment.
In the present invention, vascular occlusion device is processed into required size by 510 DEG C of thermal finalizations of high temperature, further across boron
The techniques such as sand, pickling, polishing are handled, and globoidal structure is formed.
In the present invention, the vascular occlusion device after Overheating Treatment, molding supporter form diameter refer to hot place
Reason is formed by bending arc diameter, and is shaped into the diameter of the mold of this circular arc, generally 7-20mm, preferably 10mm or
12mm。
Preferably, the supporter frame is made of a number of bar.
In the present invention, supporter frame is made of several bars of selected respective material, formed planar structure or
Globoidal structure is formed after heat treatment.
Preferably, the bar width be 0.3-0.7mm, such as can be 0.3mm, 0.35mm, 0.4mm, 0.45mm,
0.5mm, 0.55mm, 0.6mm, 0.65m or 0.7mm etc., preferably 0.5mm.
Preferably, the bar is with a thickness of 0.05-0.12mm, for example, can be 0.05mm, 0.06mm, 0.07mm, 0.08mm,
0.09mm, 0.1mm, 0.11mm or 0.12mm etc., preferably 0.1mm.
Preferably, the material of the supporter frame is Nitinol.
In the present invention, Nitinol has shape memory effect and high resiliency.
Preferably, the length of the rock-steady structure be 18-25mm, such as can be 18mm, 19mm, 20mm, 21mm,
22mm, 23mm, 24mm or 25mm etc., preferably 21mm.
In the present invention, it if the length of rock-steady structure is too small, is not easy to stablize envelope blood；Be unfavorable for if length is too long into
Enter transportation system or blood vessel, 21mm is optimal size.
In the present invention, the length of rock-steady structure refers to the length with the axial direction along ontology diameter (or long axis).
Preferably, the shape of the ontology is round or oval, preferably circular.
In the present invention, when the shape of ontology is round or oval, it can preferably agree with transportation system and be applied.
Preferably, when the shape of ontology is round, the length of diameter is 16-25mm, for example, can be 16mm, 17mm,
18mm, 19mm, 20mm, 21mm, 22mm, 23mm, 24mm or 25mm etc., preferably 20mm.
Preferably, when the shape of ontology is ellipse, the length of long axis is 16-25mm, for example, can be 16mm,
17mm, 18mm, 19mm, 20mm, 21mm, 22mm, 23mm, 24mm or 25mm etc., preferably 20mm.
Preferably, the shape of the intermediate structure is round or oval, preferably circular.
In the present invention, when the shape of ontology is round or oval, can provide and seal formed between film it is bigger
Contact area is conducive to improve stability and haemostatic effect.
Preferably, the material of the sealing film is biodegradable material.
Preferably, the biodegradable material includes poly-L-lactide (PLLA), polyglycolic acid lactic acid copolymer
(PLGA), polyglycolide (PGA), in polylactic acid caprolactone (PLCL) any one or at least two combination, preferably poly- cream
Sour caprolactone.
In the present invention, by using biodegradable material, enable vascular occlusion device over time
Biodegrade occurs.
Preferably, the method for the outer surface that sealing film is laid in supporter frame includes solvent bonding, thermal weld, Laser Welding
It connects, the combination of any one or a variety of methods in the connection of ultrasonic welding, mechanical connection, layer, preferably solvent bonding.
Preferably, it includes any one in suture, stickup or hook that the bracing wire, which is connected to the mode of pull ring, preferably
The connection type of suture.
Preferably, the material of the bracing wire includes sheep intestines, poly-L-lactide (PLLA), polyglycolic acid lactic acid copolymer
(PLGA), polyglycolide (PGA), any one in polylactic acid caprolactone (PLCL), preferably polyglycolide.
In the present invention, the material of bracing wire can also use pure-natural collagen etc. as material.
In the present invention, precise location can be reached by controlling bracing wire with vascular occlusion device, reaches effective quick-acting haemostatic powder
Purpose.
In the present invention, the bar width of the pull ring be 0.2-0.5mm, such as can be 0.2mm, 0.3mm, 0.4mm or
0.5mm etc., preferably 0.3mm.
Preferably, the quantity of the pull ring is 2-8, such as can be 2,3,4,5,6,7 or 8,
Preferably 4.
In the present invention, the quantity of pull ring is at least 2, to reach the state that bracing wire can be connected normally.Generally preferably
It is 4, is set to body construction edge, is symmetric, be conducive to bracing wire in this way in cinching process, vascular occlusion device
Stress achievees the purpose that be close to blood vessel.
Second aspect, the present invention provides a kind of hemostatic system, the system comprises vascular occlusion device and transportation system,
The vascular occlusion device is placed in inside transportation system.
In the present invention, the arc diameter design of vascular occlusion device is general bigger than blood vessel diameter, when in the blood vessel
When release device, device there is certain tension device can be enabled to be close to blood vessel then under the tension of bracing wire blood vessel
Wall, blood form thrombus on sealing film, and the time has grown meeting endothelialization, then gradually grown together with blood vessel, blood vessel notch is just
It is plugged, sealing film and bracing wire can all degrade after the time is longer.
In the present invention, the operating process of hemostatic system is that vascular occlusion device curling is placed in the pipe of transportation system
In chamber, tenses bracing wire in blood vessel incision by release vascular occlusion device and closing device is made to be close to blood vessel when hemostasis, due to
The effect of sealing film is capable of forming thrombus, prevents blood from flowing out, thus achieve the purpose that quick-acting haemostatic powder, postoperative sealing film and bracing wire
Biodegrade can occur as time goes by.
Hemostatic system provided by the invention, it is easy to operate, and target site can be accurately positioned, postoperative blood can be made
Pipe quick closure, achievees the effect that quick-acting haemostatic powder, avoids the problem that causing blood vessel distortion.
Compared with the existing technology, the invention has the advantages that：
Vascular occlusion device provided by the invention, by being provided with rock-steady structure around supporter frame, so that device
There is higher stability, and intermediate structure is provided with by heart position in the body, so that sealing the contact surface of film
Product is bigger, further improves stability and haemostatic effect, and sealing intermediate shape after membrane degradation can mention for operation next time
For basis.Since the effect of sealing film is capable of forming thrombus, prevent blood from flowing out, so that in intervention operation, it can be effective
Reach hemostasis purpose, reduces operating time, improves surgical hemostasis difficulty and complexity.
Detailed description of the invention
Fig. 1 is the schematic diagram after the heat treatment of 1 vascular occlusion device of the embodiment of the present invention, and wherein 1- supporter frame, 2- are close
Sealer, 3- bracing wire, 4- pull ring, 5- rock-steady structure, 6- circular body, 7- circle intermediate structure.
Fig. 2 is the not thermally treated planar structure schematic diagram of 2 vascular occlusion device of the embodiment of the present invention, wherein 1- supporter
Frame, 2- seal film, 3- bracing wire, 4- pull ring, 5- rock-steady structure, 6- circular body, 7- circle intermediate structure.
Fig. 3 is the not thermally treated planar structure schematic diagram of 3 vascular occlusion device of the embodiment of the present invention, wherein 1- supporter
Frame, 2- seal film, 3- bracing wire, 4- pull ring, 5- rock-steady structure, 6- circular body, 7- ellipse intermediate structure.
Fig. 4 is application schematic diagram of the 4 medium vessels closing device of the embodiment of the present invention in hemostatic system.
Fig. 5 is the planar structure schematic diagram of 1 medium vessels closing device of comparative example of the present invention, wherein 1- supporter frame, 2-
Seal film, 4- pull ring, 5- rock-steady structure, 6- circular body.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
Embodiment 1
Vascular occlusion device (as shown in Figure 1) after heat treatment provided in this embodiment, including supporter frame 1 and sealing
Film 2, supporter frame 1 include circular body 6 and rock-steady structure 5, and the edge of circular body 6 is convexly equipped with the stable knot being oppositely arranged
Structure 5, the center position of circular body 6 are provided with round intermediate structure 7, and sealing film 2 is laid by way of solvent bonding
In on the entire outer surface of supporter frame 1, circular body 6 includes that four pull rings 4 and two bracing wires 3, pull ring 4 are set to circle
The edge of ontology 6, bracing wire 3 are connected between two pull rings being oppositely arranged 4 by way of suture.
Wherein, the material of supporter frame 1 is Nitinol, and the material of sealing film 2 is polylactic acid caprolactone, bracing wire 3
Material is polyglycolide；The bar width of supporter frame 1 is 0.5mm, with a thickness of 0.1mm；The diameter of circular body 6 is 20mm；
The bar width of pull ring is 0.3mm；The length of rock-steady structure 5 is 21mm.
Embodiment 2
Not thermally treated vascular occlusion device (as shown in Figure 2) provided in this embodiment, including supporter frame 1 and close
Sealer 2, supporter frame 1 include circular body 6 and rock-steady structure 5, and the edge of circular body 6 is convexly equipped with the stabilization being oppositely arranged
Structure 5, the center position of circular body 6 are provided with round intermediate structure 7, seal film 2 and are applied by way of ultrasonic welding
On the entire outer surface of supporter frame 1, circular body 6 includes that four pull rings 4 and two bracing wires 3, pull ring 4 are set to circle
The edge of shape ontology 6, bracing wire 3 are connected between two pull rings being oppositely arranged 4 by way of hook.
Wherein, the material of supporter frame 1 is Nitinol, and the material of sealing film 2 is polyglycolic acid lactic acid copolymer,
The material of bracing wire 3 is polylactic acid caprolactone；The bar width of supporter frame 1 is 0.3mm, with a thickness of 0.12mm；Circular body 6
Diameter is 25mm；The bar width of pull ring is 0.2mm；The length of rock-steady structure 5 is 25mm.
Embodiment 3
Not thermally treated vascular occlusion device (as shown in Figure 3) provided in this embodiment, including supporter frame 1 and close
Sealer 2, supporter frame 1 include circular body 6 and rock-steady structure 5, and the edge of circular body 6 is convexly equipped with the stabilization being oppositely arranged
Structure 5, the center position of circular body 6 are provided with oval intermediate structure 7, seal film 2 by way of mechanical connection
It is laid on the outer surface of supporter frame 1, circular body 6 includes that four pull rings 4 and two bracing wires 3, pull ring 4 are set to circle
The edge of ontology 6, bracing wire 3 are connected between two pull rings being oppositely arranged 4 by way of stickup.
Wherein, the material of supporter frame 1 is Nitinol, and the material of sealing film 2 is poly-L-lactide, the material of bracing wire 3
Material is sheep intestines；The bar width of supporter frame 1 is 0.7mm, with a thickness of 0.05mm；The diameter of circular body 6 is 16mm；Pull ring
Bar width is 0.5mm；The length of rock-steady structure 5 is 18mm.
Embodiment 4
The application that the present embodiment provides vascular occlusion devices in hemostatic system
Vascular occlusion device curling is placed in the lumen of transportation system (as shown in Figure 4), by discharging blood when hemostasis
Pipe closing device tenses bracing wire and closing device is made to be close to blood vessel in blood vessel incision, since the effect of sealing film is capable of forming
Thrombus prevents blood from flowing out, to achieve the purpose that quick-acting haemostatic powder, postoperative sealing film and bracing wire can give birth to as time goes by
Object degradation.
Comparative example 1
This comparative example provides a kind of vascular occlusion device (as shown in Figure 5) comprising and supporter frame 1 seals film 2,
Pull ring 4, rock-steady structure 5, circular body 6.As can be seen from Figure, the vascular occlusion device provided in this comparative example is without centre
Body rock-steady structure, and rock-steady structure 5 is only arranged in unilateral side.
It is found by practical application, due to having lacked the stabilising arrangement of side, such vascular occlusion device stability is poor；
And the missing of intermediate structure, it causes sealing film and is not easy to be close to vascular wall, haemostatic effect decline is unfavorable for stopping blooding.
The Applicant declares that the present invention is explained by the above embodiments vascular occlusion device and hemostatic system of the invention,
But the invention is not limited to above-mentioned processing steps, that is, do not mean that the present invention must rely on the above process steps to be carried out.
It should be clear to those skilled in the art, any improvement in the present invention, replaces to the equivalent of raw material selected by the present invention
It changes and the addition of auxiliary element, the selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of vascular occlusion device, which is characterized in that including supporter frame and sealing film, the supporter frame includes this
Body and rock-steady structure, the edge of the ontology are convexly equipped with multiple rock-steady structures being oppositely arranged, the center position of the ontology
It is provided with intermediate structure, the sealing film is laid on the outer surface of the supporter frame.
2. vascular occlusion device according to claim 1, which is characterized in that the ontology includes multiple pull rings and multiple drawings
Line, the pull ring are set to the edge of the ontology, and a bracing wire is connected to two pull rings being oppositely arranged；
Preferably, the vascular occlusion device forms globoidal structure through Overheating Treatment.
3. vascular occlusion device according to claim 1 or 2, which is characterized in that the supporter frame is by a number of
Bar composition；
Preferably, the bar width is 0.3-0.7mm, preferably 0.5mm；
Preferably, the bar is with a thickness of 0.05-0.12mm, preferably 0.1mm.
4. vascular occlusion device according to any one of claim 1-3, which is characterized in that the material of the supporter frame
Material is Nitinol.
5. vascular occlusion device described in any one of -4 according to claim 1, which is characterized in that the length of the rock-steady structure
For 18-25mm, preferably 21mm.
6. vascular occlusion device according to any one of claims 1-5, which is characterized in that the shape of the ontology is circle
Shape or ellipse, it is preferably circular；
Preferably, when the shape of ontology is round, the length of diameter is 16-25mm, preferably 20mm；
Preferably, when the shape of ontology is ellipse, the length of long axis is 16-25mm, preferably 20mm；
Preferably, the shape of the intermediate structure is round or oval, preferably circular.
7. vascular occlusion device according to claim 1 to 6, which is characterized in that it is described sealing film material be
Biodegradable material；
Preferably, the biodegradable material includes poly-L-lactide, polyglycolic acid lactic acid copolymer, polyglycolide, gathers
In lactic acid caprolactone any one or at least two combination, preferred polylactic acid caprolactone；
Preferably, the method for the sealing film outer surface that is laid in supporter frame include solvent bonding, thermal weld, laser welding,
The combination of ultrasonic welding, mechanical connection, any one or a variety of methods in layer connection, preferably solvent bonding.
8. vascular occlusion device described in any one of -7 according to claim 1, which is characterized in that the bracing wire is connected to pull ring
Mode include suture, paste or hook in any one, the connection type preferably sutured；
Preferably, the material of the bracing wire include sheep intestines, poly-L-lactide, polyglycolic acid lactic acid copolymer, polyglycolide,
Any one in polylactic acid caprolactone, preferably polyglycolide.
9. vascular occlusion device according to claim 1 to 8, which is characterized in that the bar width of the pull ring is
0.2-0.5mm, preferably 0.3mm；
Preferably, the quantity of the pull ring is 2-8, preferably 4.
10. a kind of hemostatic system, which is characterized in that the system comprises vascular occlusion device and transportation system, the blood vessel is closed
Storing is attached together to be placed in inside transportation system.
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| CN201810747066.5A CN108852449B (en) | 2018-07-09 | 2018-07-09 | Blood vessel closing device and hemostasis system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386298A (en) * | 2020-11-19 | 2021-02-23 | 张慧 | Clinical hemostasis rescue device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015009634A2 (en) * | 2013-07-15 | 2015-01-22 | E-Pacing, Inc. | Vasculature closure devices and methods |
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2018
- 2018-07-09 CN CN201810747066.5A patent/CN108852449B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015009634A2 (en) * | 2013-07-15 | 2015-01-22 | E-Pacing, Inc. | Vasculature closure devices and methods |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386298A (en) * | 2020-11-19 | 2021-02-23 | 张慧 | Clinical hemostasis rescue device |
| CN112386298B (en) * | 2020-11-19 | 2022-05-27 | 张慧 | Clinical hemostasis rescue device |
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| CN108852449B (en) | 2022-02-18 |
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