CN108852366A - The integrated flexible wearable sensors of multicomponent sweat detection - Google Patents
The integrated flexible wearable sensors of multicomponent sweat detection Download PDFInfo
- Publication number
- CN108852366A CN108852366A CN201810886374.6A CN201810886374A CN108852366A CN 108852366 A CN108852366 A CN 108852366A CN 201810886374 A CN201810886374 A CN 201810886374A CN 108852366 A CN108852366 A CN 108852366A
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- electrode
- sweat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
Abstract
The present invention relates to the integrated flexible wearable sensors of multicomponent sweat detection,The sensor is respectively by GOx electrode,Lox electrode and Ag/AgCl electrode are constituted,The GOx electrode is to the sugared content reaction condition for being used to test in glucose and blood of human body in sweat,The Lox electrode reflects pressure Anemia to the lactate for being used to test in sweat,Skin temperature and a variety of diseases,The Ag/AgCl electrode is existed as the reference electrode of the GOx electrode and the Lox electrode and to electrode,The content of glucose and lactate is directly proportional in the size of current and sweat that corresponding reaction generates,The Ag/AgCl electrode is existed as the reference electrode of the GOx electrode and the Lox electrode and to electrode,The content of glucose and lactate is directly proportional in the size of current and sweat that corresponding reaction generates,The preparation of multielectrode sensor,It is equipped with the correction of temperature sensor,In conjunction with the adjusting of current signal,Simultaneously plus the Bluetooth accessory on sensor,Mobile phone app and cloud database,Realize multicomponent while accurate efficient real-time detection in sweat,It reads and stores,User is allowed to understand the physiologic information of oneself constantly.
Description
Technical field
The present invention relates to biochemical sensor fields, it is more particularly related to the integration of multicomponent sweat detection
Flexible wearable sensor.
Background technique
Biosensor is widely used in fields such as medicine, health and movements.But common biography currently on the market
Sensor, such as most commonly used blood glucose meter, will cause the pain of user, and cannot achieve real-time detection.Wearable flexible sensing
Device can be carried, every physical signs of real-time detection human body.The wearable sensors that can be bought on Vehicles Collected from Market are only
It can detecte the physical activity of human body(Such as step number)Or vital sign(Such as heartbeat), and cannot provide from molecule angle and provide
The health status of inside of human body makes it have certain limitation.
Sweat is the important secretion of human metabolism, is rich in physiologic information abundant, while the acquisition of sweat is not necessarily to
It causes harm to the human body.But the acquisition and detection of the sweat having been carried out at present are separation, for object different in sweat
Matter, analysis need to use the laboratory equipment of a variety of large sizes, therefore can not provide a real-time physical condition analysis.Forefathers
Also there is the design for attempting the sensor for detecting sweat, there are problems that all is mostly solution, such as contained in sweat
Chemical substance is abundant, can not be detected with unitary electrode;It can generate and interfere with each other between chemical substance, so that the signal obtained
Accuracy is poor.Therefore, if real-time, efficient, the accurate and diversified detection to sweat may be implemented, there will be huge market
Prospect.
Summary of the invention
The purpose of the present invention is to provide the integrated flexible wearable sensors of multicomponent sweat detection, pass through sensor
Electrode reflect pressure Anemia, skin temperature the sugared content and lactate tested in glucose and blood of human body in sweat
Degree and a variety of diseases.
In order to achieve the above object, solution of the invention is that the integrated flexible of invention multicomponent sweat detection can be worn
Wear sensor, the sensor is made of GOx electrode, Lox electrode and Ag/AgCl electrode respectively, the GOx electrode to
Come the sugared content reaction condition tested in glucose and blood of human body in sweat, the Lox electrode to be used to test sweat
In lactate reflection pressure Anemia, skin temperature and a variety of diseases, the Ag/AgCl electrode is as described
The reference electrode of GOx electrode and the Lox electrode and exist to electrode, Portugal in the size of current and sweat that corresponding reaction generates
The content of grape sugar and lactate is directly proportional;
Preferably, the sensor is additionally provided with temperature controller, for adjusting the temperature in sensor to adjust, comes in fact for detecting
Now transmit the correction of signal.
Preferably, the raw material of the temperature controller is made of chromium or gold.
Preferably, the sensor can be according to detection information demand, equipped with the electrode for testing sodium ion in sweat
Or any one of the electrode of the electrode or other ions of potassium ion.
The application method of the integrated flexible wearable sensors of multicomponent sweat detection, including:Using sensor, and lead to
GOx electrode and Lox electrode are crossed close to skin, passes through two strands of electric currents(GOx and Lox route signal)Respective signal is respectively enterd to put
Inverter is entered back into after big device, and respectively enters low-pass filter, rear converge enters microcontroller together, and the resistance signal of temperature
Into divider, then summarize into microcontroller, the signal after acquisition comes out the indigo plant for entering sensor internal from microcontroller
Tooth transmitting device, signal enters cell phone application, while the signal can also be transferred to cloud and be stored, and forms personal physiology letter
Library is ceased, the health consultation suggestion of tracing type is provided.
The present invention by same sensor device single, it is continuous or duplicate in a manner of sweat is realized it is effective
Premised on stimulation and analysis.By the present invention in that perspiration sensor can be controlled by dynamic in real time, sensed with reducing by sweat
Device generate energy consumption, optimize sensor service life and performance, allow finite lifetime sensor use and manage skin or
Sweat contacts matters, to solve various difficulties comprising above-mentioned analysis.Specifically, the present invention provides:The GOx electrode to
Come the sugared content reaction condition tested in glucose and blood of human body in sweat, the Lox electrode to be used to test sweat
In lactate reflection pressure Anemia, skin temperature and a variety of diseases, the Ag/AgCl electrode is as described
The reference electrode of GOx electrode and the Lox electrode and exist to electrode, Portugal in the size of current and sweat that corresponding reaction generates
The content of grape sugar and lactate is directly proportional, and the preparation of multielectrode sensor is equipped with the correction of temperature sensor, in conjunction with current signal
Adjusting realize in sweat multicomponent simultaneously while plus Bluetooth accessory, mobile phone app and the cloud database on sensor
Accurate efficient real-time detection, reading and storage, allow user to understand the physiologic information of oneself constantly.
Detailed description of the invention
Fig. 1 is sensor structure schematic diagram.
Specific embodiment
Below with reference to specific embodiment to the integrated flexible wearable sensors of multicomponent sweat detection of the invention
It is further elaborated, to make more complete and clear explanation to technical solution of the present invention.
The integrated flexible wearable sensors of multicomponent sweat detection of the invention, the sensor is respectively by GOx
Electrode 2, Lox electrode 4 and Ag/AgCl electrode 3 are constituted, and 3 electrodes are fabricated on soft gather to benzene by screen printing technique
Naphthalate(PET)In substrate 1, it ensure that its wearable property and the close contact with skin, then take a certain amount of
The glucose oxidase and lactate oxidase of concentration be added dropwise respectively after enhancing electron transmission efficiency in 2 electrodes
On, glucose oxidase drop in GOx electrode 2 and lactate oxidase drop in Lox electrode 4, and wait it is to be dried after plate one layer of tool again
It after the film for having liquid penetration capacity, that is, can be made into, the GOx electrode 2 is to the glucose and human body for being used to test in sweat
Sugared content reaction condition in blood, the Lox electrode 4 reflect pressure anemia to the lactate for being used to test in sweat
Shape, skin temperature and a variety of diseases, the Ag/AgCl electrode 3 are as the GOx electrode 2 and the Lox electrode 4
Reference electrode and exist to electrode, the content of glucose and lactate is at just in the size of current and sweat that corresponding reaction generates
Than;The sensor is additionally provided with temperature controller 5, and for adjusting the temperature in sensor to adjust, transmission is realized for detecting
The correction of signal, the raw material of the temperature controller 5 are that effect made of chromium or gold is best, according to demand, can increase it
His detecting electrode, such as sodium ion, the electrode of potassium ion, so that detection information is more diversified.
The method of the integrated flexible wearable sensors of multicomponent sweat detection, including:Using sensor, and pass through
GOx electrode and Lox electrode pass through two strands of electric currents close to skin(GOx and Lox route signal)Respectively enter respective signal amplification
Enter back into inverter after device, and respectively enter low-pass filter, rear converge enters microcontroller together, and the resistance signal of temperature into
Enter divider, then summarize into microcontroller, single, continuous or duplicate mode to sweat realize effective stimulation and
Premised on analysis, the signal after acquisition comes out the bluetooth transmission means for entering sensor internal from microcontroller, and signal enters hand
Machine APP, while the signal can also be transferred to cloud and be stored, and form personal physiologic information library, provide the health of tracing type
Consulting is suggested, by the present invention in that perspiration sensor can be controlled by dynamic in real time, is generated with reducing by sweat sensing device
Energy consumption, optimize sensor service life and performance, allow finite lifetime sensor use and management skin or sweat contact
Matters, to solve various difficulties comprising above-mentioned analysis.
The present invention is by above-mentioned setting, by the GOx electrode to glucose and the people for being used to test in sweat
Sugared content reaction condition in body blood, the Lox electrode reflect pressure anemia to the lactate for being used to test in sweat
Shape, skin temperature and a variety of diseases, the Ag/AgCl electrode are the ginsengs as the GOx electrode and the Lox electrode
Existing than electrode and to electrode, the content of glucose and lactate is directly proportional in the size of current and sweat that corresponding reaction generates,
The preparation of multielectrode sensor is equipped with the correction of temperature sensor, in conjunction with the adjusting of current signal, while plus on sensor
Bluetooth accessory, mobile phone app and cloud database, realize in sweat multicomponent efficient real-time detection accurate simultaneously, read and
Storage, allows user to understand the physiologic information of oneself constantly.
For the ordinary skill in the art, specific embodiment is only exemplarily described the present invention,
Obviously the present invention specific implementation is not subject to the restrictions described above, as long as use the inventive concept and technical scheme of the present invention into
The improvement of capable various unsubstantialities, or not improved the conception and technical scheme of the invention are directly applied to other occasions
, it is within the scope of the present invention.
Claims (5)
1. the integrated flexible wearable sensors of multicomponent sweat detection, it is characterised in that:The sensor is respectively by GOx
Electrode, Lox electrode and Ag/AgCl electrode are constituted, and the GOx electrode is to the glucose and blood of human body for being used to test in sweat
In sugared content reaction condition, the Lox electrode reflects pressure Anemia, skin to being used to test lactate in sweat
Temperature and a variety of diseases, the Ag/AgCl electrode are the reference electrodes as the GOx electrode and the Lox electrode
Exist with to electrode, the content of glucose and lactate is directly proportional in the size of current and sweat that corresponding reaction generates.
2. the integrated flexible wearable sensors of multicomponent sweat detection according to claim 1, it is characterised in that:Institute
The sensor stated is additionally provided with temperature controller, and for adjusting the temperature in sensor to adjust, transmission signal is realized for detecting
Correction.
3. the integrated flexible wearable sensors of multicomponent sweat detection according to claim 2, it is characterised in that:Institute
The raw material for the temperature controller stated is made of chromium or gold.
4. the integrated flexible wearable sensors of multicomponent sweat detection according to claim 1, it is characterised in that:Institute
The sensor stated can according to detection information demand, equipped with for test in sweat the electrode of sodium ion or the electrode of potassium ion or its
Any one of the electrode of his ion.
5. the method for the integrated flexible wearable sensors of multicomponent sweat detection, including:
Pass through two strands of electric currents close to skin using sensor, and by GOx electrode and Lox electrode(GOx and Lox route signal)
Inverter is entered back into after respectively enteing respective signal amplifier, and respectively enters low-pass filter, rear converge enters micro-control together
Device processed, and the resistance signal of temperature enters divider, then summarizes into microcontroller, the signal after acquisition goes out from microcontroller
Enter the bluetooth transmission means of sensor internal, signal enters cell phone application, while the signal can also be transferred to cloud and be stored up
It deposits, forms personal physiologic information library, the health consultation suggestion of tracing type is provided.
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Cited By (9)
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---|---|---|---|---|
CN109646015A (en) * | 2019-01-17 | 2019-04-19 | 浙江大学 | A kind of wireless and passive flexible sensing device and method for sweat ion detection |
CN110220950A (en) * | 2019-06-24 | 2019-09-10 | 西北工业大学 | Wearable glucose sensor chip and preparation method based on golden aeroge working electrode |
CN110672687A (en) * | 2019-10-29 | 2020-01-10 | 北京科技大学 | Adhesive tape base electrochemical sweat sensor |
CN110988057A (en) * | 2019-12-09 | 2020-04-10 | 浙江清华柔性电子技术研究院 | Sweat sensor, integrated electrode array and preparation method thereof |
CN111007124A (en) * | 2019-12-04 | 2020-04-14 | 中国科学院电子学研究所 | Sensor for sweat detection and preparation method thereof |
CN113219034A (en) * | 2021-04-30 | 2021-08-06 | 浙江工业大学 | MXene-based flexible wearable sensor for multi-component sweat detection and preparation method thereof |
CN113892946A (en) * | 2021-09-17 | 2022-01-07 | 天津工业大学 | Preparation method of sweat sensing bandage based on SERS |
CN114397344A (en) * | 2022-01-07 | 2022-04-26 | 湖北大学 | Single-wall carbon nanotube-based flexible electrode array, wearable sensor and sweat in-situ monitoring method thereof |
CN115281516A (en) * | 2022-02-16 | 2022-11-04 | 浙江理工大学 | Intelligence sweat detects glass holder |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109646015A (en) * | 2019-01-17 | 2019-04-19 | 浙江大学 | A kind of wireless and passive flexible sensing device and method for sweat ion detection |
CN110220950A (en) * | 2019-06-24 | 2019-09-10 | 西北工业大学 | Wearable glucose sensor chip and preparation method based on golden aeroge working electrode |
CN110672687A (en) * | 2019-10-29 | 2020-01-10 | 北京科技大学 | Adhesive tape base electrochemical sweat sensor |
CN111007124A (en) * | 2019-12-04 | 2020-04-14 | 中国科学院电子学研究所 | Sensor for sweat detection and preparation method thereof |
CN110988057A (en) * | 2019-12-09 | 2020-04-10 | 浙江清华柔性电子技术研究院 | Sweat sensor, integrated electrode array and preparation method thereof |
CN113219034A (en) * | 2021-04-30 | 2021-08-06 | 浙江工业大学 | MXene-based flexible wearable sensor for multi-component sweat detection and preparation method thereof |
CN113892946A (en) * | 2021-09-17 | 2022-01-07 | 天津工业大学 | Preparation method of sweat sensing bandage based on SERS |
CN113892946B (en) * | 2021-09-17 | 2023-10-31 | 天津工业大学 | Preparation method of sweat sensing binding band based on SERS |
CN114397344A (en) * | 2022-01-07 | 2022-04-26 | 湖北大学 | Single-wall carbon nanotube-based flexible electrode array, wearable sensor and sweat in-situ monitoring method thereof |
CN115281516A (en) * | 2022-02-16 | 2022-11-04 | 浙江理工大学 | Intelligence sweat detects glass holder |
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