CN108852354A - Magnetic resonance equipment and method - Google Patents
Magnetic resonance equipment and method Download PDFInfo
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- CN108852354A CN108852354A CN201810491377.XA CN201810491377A CN108852354A CN 108852354 A CN108852354 A CN 108852354A CN 201810491377 A CN201810491377 A CN 201810491377A CN 108852354 A CN108852354 A CN 108852354A
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- 238000000034 method Methods 0.000 title claims abstract description 12
- 230000005284 excitation Effects 0.000 claims abstract description 119
- 108010076504 Protein Sorting Signals Proteins 0.000 claims abstract description 39
- 238000004804 winding Methods 0.000 claims description 13
- 238000012545 processing Methods 0.000 claims description 9
- 238000001646 magnetic resonance method Methods 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000010586 diagram Methods 0.000 description 10
- 210000004556 brain Anatomy 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 241000238366 Cephalopoda Species 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000005389 magnetism Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000009529 traumatic brain injury Effects 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007570 microbleeding Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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Abstract
The present invention discloses a kind of ultralow magnetic fields magnetic resonance equipment and method.Method includes generating signal sequence according to preset timing by control subsystem；Pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses are generated by power subsystem；Pre-polarizing magnetic field pulse, excitation magnetic field pulse, gradient magnetic field pulses and signal sequence are received by excitation subsystem and generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；Pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal are received by receiving subsystem and generates magnetic resonance signal and is sent to control subsystem, so that control subsystem generates image, is met with this and actual uses needs.The magnetic resonance equipment is at low cost, small in size, easy to carry, is suitable for special medical applications scene.
Description
Technical field
The present invention relates to field of medical equipment, more particularly to a kind of magnetic resonance equipment and method.
Background technique
Medical magnetic resonance equipment (MRI) is polarized the proton moment of patient's body by magnetic field.The magnetic moment that polarizes is further
After excitation, the magnetic resonance signal of generation is received by receiving coil, then each by that can obtain human body after image procossing
The clinical high-resolution diagnostic image at a position and each organ.Wherein, the MRI of brain is due to having to human brain part elementary organization
Structure (such as hydrocrania, ectocinerea, white matter of brain) and accordingly possible lesion progress Precise Diagnosis and dynamic monitor, have become
Brain diseases diagnosis " goldstandard ", be one of most important clinical application in magnetic resonance, at the same be also can not be substituted show
For Medical Imaging Technology.
(1) high-field magnetic resonance equipment needs 30-40 square metres of mounting area (including independent scanning room, independent
Equipment room and independent operation room etc.) and magnetic screen and radio shielding to whole equipment, equipment always weigh about 5 tons.1.5 special
This draws or the magnetic field of 3.0 teslas is by the way that caused by the large scale superconducting magnet in ultra-low temperature surroundings, this needs equipment to protect
Hold ultralow temperature, keep being isolated from the outside, and cannot by the interference of change of external conditions, so from equipment size, weight and
For the high susceptibility of external environment, conventional medical magnetic resonance equipment is not suitable for portable environments and battlefield environment.
(2) working frequency and magnetic field strength of magnetic resonance equipment are directly proportional.For the magnetic of 1.5 teslas or 3.0 teslas
Resonant device, working frequency will respectively reach 64MHz and 128MHz, and under such high frequency environment, patient is possible to go out
Existing whole body or hot-spot can generate hidden danger to the safety of patient in this way.
The magnetic field of (3) 1.5 teslas or 3.0 teslas will generate cause to the patient for having metal implant or elastic slice in vivo
The influence of life.Estimate that since the war in Iraq and Afghanistan, there is about 300,000 soldiers trouble in the U.S. in US veteran population affairs portion
Have traumatic brain injury syndrome (TBI), the reason in part for large-scale war sequelae patient in this way occurs, be due to being disliked in battlefield
Bad environment can not be using existing magnetic resonance equipment to soldier's (mainly oedema of brain and micro bleeding) of traumatic brain injury
Early treatment is rapidly and accurately diagnosed and is carried out, and existing magnetic resonance equipment is also completely unusable for body interior and has
The wounded soldier of metal or elastic slice.
And existing ultralow magnetic fields magnetic resonance equipment is to be needed using superconduction low temperature SQUID device using cooled cryostat
SQUID is placed, and safeguards and control low temperature environment in use, thus affects equipment in various adverse circumstances
Normal use；And the use condition special due to superconduction low temperature SQUID, whole equipment need special magnetic shielding device to support
Disappear the interference in various extraneous low-frequency noise magnetic fields, this increase considerably the size, weight and design complexity of equipment can.Cause
This, existing high-field magnetic resonance equipment and ultralow magnetic fields magnetic resonance equipment are not able to satisfy actual use needs.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of magnetic resonance equipments at low cost, small in size and easy to carry
And method, it is actual using needs to meet.
In order to solve the above technical problems, one technical scheme adopted by the invention is that：A kind of ultralow magnetic fields magnetic resonance is provided
Equipment, including memory, processor, controller and the communication for connecting the memory, the processor and the controller
Bus：
The memory be used for store preset pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses when
Sequence；
The controller is used to generate signal sequence according to preset timing；
The processor is for generating pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses；
The processor is for receiving the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic arteries and veins
Punching and the signal sequence simultaneously generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
The controller for receive the pre-polarizing magnetic field signal, excitation magnetic field signal and the gradient magnetic signal with
It generates magnetic resonance signal and generates image after handling the magnetic resonance signal.
In order to solve the above technical problems, one technical scheme adopted by the invention is that：A kind of ultralow magnetic fields magnetic resonance is provided
Equipment, including：
Control subsystem, for generating signal sequence according to preset timing；
Power subsystem, for generating pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses；
Subsystem is excited, for receiving the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic arteries and veins
Punching and the signal sequence simultaneously generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
Receive subsystem, for receiving the pre-polarizing magnetic field signal, the excitation magnetic field signal and the gradient magnetic
Signal is to generate magnetic resonance signal and generate image after handling the magnetic resonance signal.
In order to solve the above technical problems, one technical scheme adopted by the invention is that：A kind of ultralow magnetic fields magnetic resonance is provided
Method is applied to magnetic resonance equipment, including：
Signal sequence is generated according to preset timing by control subsystem；
Pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses are generated by power subsystem；
The pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic arteries and veins are received by excitation subsystem
Punching and the signal sequence simultaneously generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
The pre-polarizing magnetic field signal, the excitation magnetic field signal and gradient magnetic letter are received by receiving subsystem
Number to generate magnetic resonance signal and be sent to the control subsystem, so that the control subsystem generates image.
The beneficial effects of the invention are as follows：It is in contrast to the prior art, the ultralow magnetic fields magnetic resonance of the invention is set
Standby and method by the control subsystem generate signal sequence and by the power subsystem generate pulse signal and by its
The excitation subsystem is supplied to generate pre-polarizing magnetic field, excitation magnetic field and gradient magnetic, and receive subsystem by described
Generate magnetic resonance signal and be supplied to the control subsystem to generate image, with this meet it is actual using needs and at low cost,
It is small in size, easy to carry.
Detailed description of the invention
Fig. 1 is the frame structure schematic diagram of magnetic resonance equipment of the invention；
Fig. 2 is the structural schematic diagram of each subsystem of Fig. 1；
Fig. 3 is the space configuration schematic diagram of the excitation subsystem in Fig. 2；
Fig. 4 is the hardware structural diagram of magnetic resonance equipment of the invention；
Fig. 5 to Fig. 9 is the flow diagram of magnetic resonance method of the invention.
Specific embodiment
Referring to Fig. 1, being the structural schematic diagram of ultralow magnetic fields magnetic resonance equipment of the invention.The ultralow magnetic fields magnetic resonance
Equipment includes control subsystem 10, for generating signal sequence according to preset timing；Power subsystem 20, for generating pre- pole
Energy needed for magnetizing field pulse, excitation magnetic field pulse and gradient magnetic field pulses；Subsystem 30 is excited, for receiving the pre- pole
Magnetizing field pulse, the excitation magnetic field pulse, the gradient magnetic field pulses and the signal sequence simultaneously generate pre-polarizing magnetic field letter
Number, excitation magnetic field signal and gradient magnetic signal；Receive subsystem 40, for receive the pre-polarizing magnetic field signal, it is described swash
Magnetic field signal and the gradient magnetic signal are sent out to generate magnetic resonance signal and the magnetic resonance signal is sent to the control
Subsystem 10, so that the control subsystem 10 generates image.
Referring to Fig. 2, being the structural schematic diagram of each subsystem of ultralow magnetic fields magnetic resonance equipment of the invention.The control
Subsystem 10 includes wave generating unit 11, and for generating signal sequence according to preset timing, the signal sequence includes pre-
Polarized signal, excitation signal, gradient signal, specifically, the pre-polarizing signal include pre-polarizing pulsed magnetic field signal, described to swash
It signals to include 90 degree of excitation signals and 180 degree excitation signal, the gradient signal includes Z-Gradient layer selection signal, Y-gradient phase
Encoded signal and X-gradient frequency coded signal.
Control unit 12 receives subsystem 40 to the excitation subsystem 30 and from described for sending the signal sequence
It receives the magnetic resonance signal and is supplied to image processing unit 13；
Described image processing unit 13, for generating image.
The power subsystem 20 includes pre-polarizing power supply 21, for energy needed for generating pre-polarizing magnetic field pulse；It penetrates
Audio amplifier 22, for energy needed for generating excitation magnetic field pulse；Gradient amplifier 23, for generating gradient magnetic field pulses institute
The energy needed.
The excitation subsystem 30 includes shimming bar magnet 31, for generating uniform magnetic field；Pre-polarizing coil 32, for receiving
The pre-polarizing signal and the pre-polarizing magnetic field pulse, to generate pre-polarizing magnetic field；Excitation variable winding 33, it is described sharp for receiving
Signalling and the excitation magnetic field pulse, to generate excitation magnetic field；Gradient coil 34, for receiving the gradient signal and described
Gradient magnetic field pulses, to generate gradient magnetic.
Specifically, the pre-polarizing coil 32 receives pre-polarizing signal that the wave generating unit 11 generates and described pre-
Pre-polarizing pulsed magnetic field Bp is generated after the energy that polarization power supply 21 provides；The excitation variable winding 33 receives the wave generating unit
90 degree of excitations are generated after the 11 90 degree of excitation signals generated or 180 degree excitation signal and the energy that the offer of rate amplifier 22 is provided
Pulsed magnetic field B1 or 180 degree excitation pulse magnetic field B1；The gradient coil 34 receives the Z ladder that the wave generating unit 11 generates
Spend the energy that layer selection signal or Y-gradient phase bit number signal or X-gradient frequency coded signal and the gradient amplifier 23 provide
Slice selective gradient pulsed magnetic field Gz, phase encoding gradient pulses magnetic field Gy and frequency encoding gradient pulsed magnetic field Gx are generated afterwards.
Referring to Fig. 3, being the space configuration schematic diagram of the excitation subsystem in ultralow magnetic fields magnetic resonance equipment of the invention.
Wherein, 1 is shimming bar magnet, and 2 be gradient coil Y, and 3 be gradient coil X, and 4 be gradient coil Z, and 5 be excitation variable winding, the gradient
Coil 34 is with the shimming bar magnet 31 and the excitation variable winding 33 along axial coaxial.
Wherein, the shimming bar magnet 31 is equably radially distributed by 16 or 24 or 32 permanent magnetism bar magnets and is directed toward axis
To generation steady magnetic field B0 is equal to 23.5G, spatial uniformity 100ppm, due to proton in the region of 20cm*20cm*20cm
Convolution rate be 4.26kHz/G, working frequency f0=(23.5G) * (4.26kHz/G)=100kHz of such equipment, due to connecing
0.2-2fT/Hz is of approximately by the atom magnetometer 41 in subsystem 401/2Measurement sensitivity, and extraneous high-intensitive magnetic noise
Sound is at low-frequency range (1-20kHz), so the image of the high s/n ratio with clinical value, the magnetic resonance are set in order to obtain
Standby working frequency range will be located at the range of 600-400kHz, we select 100kHz here.
The pre-polarizing coil 32 is water-cooled magnetic plug, and the preexciting stage generates 0.2T prepolarizing field Bp, normally
Pre-polarizing coil described in MR sequence stage stops working, and programmable power source chronologically drives and control the pre-polarizing coil 32
Work.
The excitation variable winding 33 is 2 or 4 symmetrical Golay excitation variable windings, in the power subsystem 20
Radio frequency amplifier 21 chronologically generates 90 degree or 180 degree excitation pulse to generate 90 degree or 180 degree excitation magnetic field.
The gradient coil 34 is made of 3 groups of coils, including two orthogonal Golay to coil and axial direction
Maxwell coil, wherein they need to generate direction for the mutually orthogonal of B1 in frequency coding stage and phase code stage
Gradient magnetic, while they need to provide spatial non-uniformity of the background shimming gradient magnetic to compensate shimming bar magnet, institute always
It states gradient coil 34 and generates the gradient magnetic of 17mG/cm as frequency encoding gradient field.
Gradient coil described above is cut-off by the gradient amplifier 23 in the power subsystem 20 by sequence timing.
It is described receive subsystem 40 include atom magnetometer 41, the atom magnetometer 41 include signal amplifier 411 and
Analog-digital converter 412, output turns to the modulus after the signal amplifier 411 amplifies the magnetic resonance signal received
Parallel operation 412, so that the analog-to-digital conversion device 412 exports after being converted into digital signal to the control subsystem 10；Heating
Device 42 receives bandwidth for heating to the atom magnetometer 41 to control the signal of the atom magnetometer 41；Biasing
Coil 43, the center that the atom magnetometer 41 is controlled for generating bias magnetic field receive frequency.In the present embodiment, described
Atom magnetometer 41 is radio frequency atomic magnetometer, and the heater 42 is internal heater, and the bias coil 43 is built-in inclined
Set coil.
Specifically, the multichannel detection system constructed using multiple atom magnetometers 41, can fundamentally improve letter
Number signal-to-noise ratio reduces sweep time, increases spatial dimension and reduces the bandwidth that receives of each atom magnetometer 41, the nonmagnetic atom
Power instrument 41 needs Metal shielding shell, to reduce the influence in earth's magnetic field, gradient fields and possible extraneous low frequency magnetic noise.It is described to add
The atom magnetometer 41 is heated up to 180-200 DEG C by hot device 42, receives bandwidth with control the atom magnetometer 41.It is described
Bias coil 43 is magnetic plug, and the magnetic field strength generated is to guarantee that potassium original spin central resonance frequency is equal to 700*B02=
100KHz (B02 is the bias magnetic field that shim coil #2 is generated), and its maximum uniformity is 1%, to guarantee the atomic magnetic force
It is 986Hz (FWHM) that the signal of instrument 41, which receives bandwidth,.
Referring to Fig. 4, being the hardware structural diagram of ultralow magnetic fields magnetic resonance equipment of the invention.The ultralow magnetic fields magnetic
Resonant device includes memory 110, processor 120, controller 130 and by the memory 110, the processor 120 and institute
State the communication bus 140 of the connection of controller 130.Communication bus 140 calls various data for processor 120, and memory 110 is used
In storage program instruction.For convenience of explanation, memory 110 shown in Fig. 9, processor 120, controller 130 and communication bus 140
Quantity be one.
The memory 110 is for storing preset pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses
Timing；
The controller 130 is used to generate signal sequence according to preset timing；
The processor 120 is for generating pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses；
The processor 120 is for receiving the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic
Pulse and the signal sequence simultaneously generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient field signal；And
The controller 130 is for receiving the pre-polarizing magnetic field signal, the excitation magnetic field signal and the gradient fields
Signal generates image after handling the magnetic resonance signal to generate magnetic resonance signal.
Specifically, the controller 130 is used to generate signal sequence according to preset timing, and the signal sequence includes pre-
Polarized signal, excitation signal, gradient signal, specifically, the pre-polarizing signal include pre-polarizing magnetic field pulse signal, described to swash
It signals to include that 90 degree of excitation magnetic field pulse signals and 180 degree excite magnetic field pulse signal, the gradient signal includes Z-Gradient choosing
Layer pulse signal, Y-gradient phase encoding pulse signal and X-gradient Frequency-Coded Pulse Signal, and the signal sequence is sent
To the processor 120.
The processor 120 is also used to generate pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses.
The processor 120 is also used to generate magnetic field according to shimming bar magnet, according to the pre-polarizing signal and the pre- pole
Magnetizing field pulse generates pre-polarizing magnetic field, generates excitation magnetic field, basis according to the excitation signal and the excitation magnetic field pulse
The gradient signal and the gradient magnetic field pulses generate gradient magnetic.
The controller 130 is also used to receive the pre-polarizing magnetic field signal, the excitation magnetic field from the processor 120
Signal and the gradient magnetic signal are to generate magnetic resonance signal and generate image after treatment.
Specifically, the processor 120 receives the pre-polarizing signal and the pre-polarizing magnetic field that the controller 130 generates
Pre-polarizing magnetic field Bp is generated after pulse；The processor 120 receives 90 degree of excitation signals or 180 that the controller 130 generates
90 degree of excitation magnetic field B1 are generated after spending excitation signal and the excitation magnetic field pulse or 180 degree excites magnetic field B1；The processor
120 receive the Z-Gradient layer selection signal that the controller 130 generates or Y-gradient phase bit number signal or X-gradient frequency coded signal
And slice selective gradient field Gz, phase encoding gradient field Gy and frequency encoding gradient field Gx are generated after the gradient magnetic field pulses.
Referring to Fig. 5, being the flow diagram of ultralow magnetic fields magnetic resonance method of the invention.The method is total applied to magnetic
Vibration equipment, including：
Step S1：Signal sequence is generated according to preset timing by control subsystem 10.
Step S2：Pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses are generated by power subsystem 20.
Step S3：By exciting subsystem 30 to receive the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the ladder
Degree magnetic field pulse and the signal sequence simultaneously generate pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal.
Step S4：It is received by receiving subsystem 40 by the pre-polarizing magnetic field signal, the excitation magnetic field signal and institute
The magnetic resonance signal of gradient magnetic signal generation is stated, and is sent to the control subsystem after handling the magnetic resonance signal
System 10, so that the control subsystem 10 generates image.
Referring to Fig. 6, the step S1 includes：
Step S11：Signal sequence is generated according to preset timing by wave generating unit 11, the signal sequence includes
Pre-polarizing signal, excitation signal, gradient signal.
Specifically, the pre-polarizing signal includes pre-polarizing magnetic field pulse signal, and the excitation signal includes 90 degree of excitations
Signal and 180 degree excitation signal, the gradient signal include Z-Gradient layer selection signal, Y-gradient phase-coded signal and X-gradient frequency
Rate encoded signal.
Step S12：The signal sequence is sent to the excitation subsystem 30 by control unit 12, and from the receiving
Subsystem 40 receives magnetic resonance signal and is supplied to image processing unit 13.
Step S13：Image is generated by described image processing unit 13.
Referring to Fig. 7, the step S2 includes：
Step S21：Energy needed for generating pre-polarizing magnetic field pulse by pre-polarizing power supply 21.
Step S22：Energy needed for generating excitation magnetic field pulse by radio frequency amplifier 22.
Step S23：Energy needed for generating gradient magnetic field pulses by gradient amplifier 23.
Referring to Fig. 8, step S3 includes：
Step S31：Magnetic field is generated by shimming bar magnet 31.
Specifically, the shimming bar magnet 31 is equably radially distributed by 16 or 24 or 32 permanent magnetism bar magnets and is directed toward axis
To generation steady magnetic field B0 is equal to 23.5G, spatial uniformity 100ppm, due to proton in the region of 20cm*20cm*20cm
Convolution rate be 4.26kHz/G, working frequency f0=(23.5G) * (4.26kHz/G)=100kHz of such equipment, due to connecing
0.2-2fT/Hz is of approximately by the atom magnetometer 41 in subsystem 401/2Measurement sensitivity, and extraneous high-intensitive magnetic noise
Sound is at low-frequency range (1-20kHz), so the image of the high s/n ratio with clinical value, the magnetic resonance are set in order to obtain
Standby working frequency range will be located at the range of 600-400kHz, we select 100kHz here.
Step S32：The pre-polarizing signal and the pre-polarizing magnetic field pulse are received by pre-polarizing coil 32, to generate
Pre-polarizing magnetic field.
Specifically, the pre-polarizing coil 32 is water-cooled magnetic plug, and the preexciting stage generates 0.2T prepolarizing field
Bp, pre-polarizing coil 32 described in normal MR sequence stage stop working, and programmable power source chronologically drives and control described pre-
Polarizing coil 32 works.
Step S33：The excitation signal and the excitation magnetic field pulse are received by excitation variable winding 33, to generate excitation magnetic
?.
Specifically, the excitation variable winding 33 is 2 or 4 symmetrical Golay excitation variable windings, the power subsystem
Radio frequency amplifier 22 in 20 chronologically generates 90 degree or 180 degree excitation pulse to generate 90 degree or 180 degree excitation magnetic field.
Step S34：The gradient signal and the gradient magnetic field pulses are received by gradient coil 34, to generate gradient magnetic
?.
Specifically, the gradient coil 34 is made of 3 groups of coils, including two orthogonal Golay to coil and one
A axial Maxwell coil, wherein they need to generate the phase that direction is B1 in frequency coding stage and phase code stage
Mutually orthogonal gradient fields, while they need to provide spatial non-uniformity of the shimming gradient to compensate shimming bar magnet always, it is described
Gradient coil 34 generates the gradient fields of 17mG/cm as frequency encoding gradient field.
Wherein, gradient coil X is GolayX gradient coil, and gradient coil Y is GolayY gradient coil, and gradient coil Z is
Maxwell Z-gradient coil, described gradient coil X, Y, Z press sequence by the gradient amplifier 23 in the power subsystem 20
Timing is cut-off.
Specifically, when the pre-polarizing coil 32 receives the pre-polarizing signal generated by the wave generating unit 11 and institute
After the energy that the offer of pre-polarizing power supply 21 is provided, generate pre-polarizing magnetic field Bp；The reception of excitation variable winding 33 is generated by the waveform
After 90 degree of excitation signals or 180 degree excitation signal and the energy that the offer of rate amplifier 22 is provided that unit 11 generates, 90 are generated
Degree excitation magnetic field B1 or 180 degree excite magnetic field B1；The gradient coil 34 receives the Z ladder generated by the wave generating unit 11
Spend the energy that layer selection signal or Y-gradient phase bit number signal or X-gradient frequency coded signal and the gradient amplifier 23 provide
Institute afterwards generates slice selective gradient field Gz, phase encoding gradient field Gy and frequency encoding gradient field Gx.The gradient coil 34 with it is described
Shimming bar magnet 31 and the excitation variable winding 33 are along axial coaxial.
Referring to Fig. 9, step S4 includes：
Step S41：After the magnetic resonance signal received is amplified by the signal amplifier 411 of atom magnetometer 41
It exports to analog-digital converter 412, so that output is sub to the control after the analog-to-digital conversion device 412 is converted into digital signal
System 10.
Specifically, the multichannel detection system constructed using multiple atom magnetometers 41, can fundamentally improve letter
Number signal-to-noise ratio reduces sweep time, increases spatial dimension and reduces the bandwidth that receives of each atom magnetometer 41, the nonmagnetic atom
Power instrument 41 needs Metal shielding shell, to reduce the influence in earth's magnetic field, gradient fields and possible extraneous low frequency magnetic noise.
Step S42：The atom magnetometer 41 is heated by heater 42, to control the atom magnetometer
Receive bandwidth.
Specifically, the atom magnetometer is heated up to 180-200 DEG C by the heater, to control the atom magnetometer
41 signal receives bandwidth.
Step S43：Bias magnetic field is generated by bias coil 43 to control the center of the atom magnetometer 41 and receive frequency
Rate.
Specifically, the bias coil 43 is magnetic plug, and the magnetic field strength generated is to guarantee potassium atom spin resonance
Frequency is equal to 700*B02=100KHz (B02 is the bias magnetic field that shim coil #2 is generated), and its maximum uniformity is 1%, with
The bandwidth that receives for guaranteeing the atom magnetometer 41 is 986Hz (FWHM).
The ultralow magnetic fields magnetic resonance equipment and method are by control subsystem generation signal sequence, and pass through described
Power subsystem generates energy required for pulse signal, and provides it to the excitation subsystem to generate pre-polarizing magnetic
Field, excitation magnetic field and gradient magnetic, and magnetic resonance signal is generated by the subsystem that receives, it is supplied to after being handled described
Control subsystem is met actual using needs and at low cost, small in size, easy to carry to generate image with this, is suitable for spy
Different medical applications scene.
Mode the above is only the implementation of the present invention is not intended to limit the scope of the invention, all to utilize this
Equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content, it is relevant to be applied directly or indirectly in other
Technical field is included within the scope of the present invention.
Claims (10)
1. a kind of ultralow magnetic fields magnetic resonance equipment, which is characterized in that the ultralow magnetic fields magnetic resonance equipment includes memory, processing
Device, controller and the communication bus for connecting the memory, the processor and the controller：
The memory is used for the timing for storing preset pre-polarizing magnetic field pulse, exciting magnetic field pulse and gradient magnetic field pulses；
The controller is used to generate signal sequence according to preset timing；
The processor is for generating pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses；
The processor for receiving the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic field pulses and
The signal sequence simultaneously generates pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
The controller is for receiving the pre-polarizing magnetic field signal, excitation magnetic field signal and the gradient magnetic signal to generate
Magnetic resonance signal simultaneously generates image after handling the magnetic resonance signal.
2. a kind of ultralow magnetic fields magnetic resonance equipment, which is characterized in that the ultralow magnetic fields magnetic resonance equipment includes：
Control subsystem, for generating signal sequence according to preset timing；
Power subsystem, for generating pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses；
Excite subsystem, for receive the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic field pulses and
The signal sequence simultaneously generates pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
Receive subsystem, for receiving the pre-polarizing magnetic field signal, the excitation magnetic field signal and the gradient magnetic signal
To generate magnetic resonance signal and generate image after handling the magnetic resonance signal.
3. ultralow magnetic fields magnetic resonance equipment according to claim 2, which is characterized in that the control subsystem includes：
Wave generating unit, for generating signal sequence according to preset timing, the signal sequence includes pre-polarizing signal, swashs
It signals, gradient signal；
Control unit, for send the signal sequence to the excitation subsystem and from it is described receive subsystem receive magnetic resonance
Signal is simultaneously supplied to image processing unit；And
Described image processing unit, for generating image.
4. ultralow magnetic fields magnetic resonance equipment according to claim 3, which is characterized in that the power subsystem includes：
Pre-polarizing power supply, for generating pre-polarizing magnetic field pulse；
Radio frequency amplifier, for generating excitation magnetic field pulse；And
Gradient amplifier, for generating gradient magnetic field pulses；
The excitation subsystem includes：
Shimming bar magnet, for generating uniform magnetic field；
Pre-polarizing coil, for receiving the pre-polarizing signal and the pre-polarizing magnetic field pulse, to generate pre-polarizing magnetic field；
Excitation variable winding, for receiving the excitation signal and the excitation magnetic field pulse, to generate excitation magnetic field；And
Gradient coil, for receiving the gradient signal and the gradient magnetic field pulses, to generate gradient magnetic.
5. ultralow magnetic fields magnetic resonance equipment according to claim 4, which is characterized in that the subsystem that receives includes：
Atom magnetometer, including signal amplifier and analog-digital converter, the magnetic resonance signal that the signal amplifier will receive
Output is to the analog-digital converter after amplifying, so that the analog-to-digital conversion device exports after being converted into digital signal to institute
State control subsystem；
Heater receives bandwidth for heating to the atom magnetometer to control the signal of the atom magnetometer；And
Bias coil, the center that the atom magnetometer is controlled for generating bias magnetic field receive frequency.
6. a kind of ultralow magnetic fields magnetic resonance method, which is characterized in that the method is applied to magnetic resonance equipment, including：
Signal sequence is generated according to preset timing by control subsystem；
Pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses are generated by power subsystem；
By excitation subsystem receive the pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic field pulses and
The signal sequence simultaneously generates pre-polarizing magnetic field signal, excitation magnetic field signal and gradient magnetic signal；And
By receive subsystem receive the pre-polarizing magnetic field signal, the excitation magnetic field signal and the gradient magnetic signal with
It generates magnetic resonance signal and is sent to the control subsystem, so that the control subsystem generates image.
7. ultralow magnetic fields magnetic resonance method according to claim 6, which is characterized in that it is described by control subsystem according to
Preset timing generates signal sequence：
Signal sequence is generated according to preset timing by wave generating unit, the signal sequence includes pre-polarizing signal, swashs
It signals, gradient signal；
Control unit, for send the signal sequence to the excitation subsystem and from it is described receive subsystem receive magnetic resonance
Signal, and it is supplied to image processing unit；And
Image is generated by described image processing unit.
8. ultralow magnetic fields magnetic resonance method according to claim 7, which is characterized in that described to be generated by power subsystem
Pre-polarizing magnetic field pulse, excitation magnetic field pulse and gradient magnetic field pulses include：
Pre-polarizing magnetic field pulse is generated by pre-polarizing power supply；
Excitation magnetic field pulse is generated by radio frequency amplifier；And
Gradient magnetic field pulses are generated by gradient amplifier.
9. ultralow magnetic fields magnetic resonance method according to claim 8, which is characterized in that described to be received by excitation subsystem
The pre-polarizing magnetic field pulse, the excitation magnetic field pulse, the gradient magnetic field pulses and the signal sequence simultaneously generate pre- pole
Magnetizing field signal, excitation magnetic field signal and gradient magnetic signal include：
Uniform magnetic field is generated by shimming bar magnet；
The pre-polarizing signal and the pre-polarizing magnetic field pulse are received by pre-polarizing coil, to generate pre-polarizing magnetic field；
The excitation signal and the excitation magnetic field pulse are received by excitation variable winding, to generate excitation magnetic field；And
The gradient signal and the gradient magnetic field pulses are received by gradient coil, to generate gradient magnetic.
10. ultralow magnetic fields magnetic resonance method according to claim 9, which is characterized in that described to be connect by receiving subsystem
The pre-polarizing magnetic field signal, the excitation magnetic field signal and the gradient magnetic signal are received to generate magnetic resonance signal and send
Include to the control subsystem：
Output turns to modulus after being amplified the magnetic resonance signal received by the signal amplifier of atom magnetometer
Parallel operation, so that the analog-to-digital conversion device exports after being converted into digital signal to the control subsystem；
The atom magnetometer is heated by heater, receives bandwidth to control the signal of the atom magnetometer；And
Bias magnetic field is generated by bias coil, and frequency is received with the center for controlling the atom magnetometer.
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