CN108852324A - A kind of pulse wave conduction speed detection system - Google Patents
A kind of pulse wave conduction speed detection system Download PDFInfo
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- CN108852324A CN108852324A CN201810788725.XA CN201810788725A CN108852324A CN 108852324 A CN108852324 A CN 108852324A CN 201810788725 A CN201810788725 A CN 201810788725A CN 108852324 A CN108852324 A CN 108852324A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
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Abstract
The invention proposes a kind of pulse wave conduction speed detection systems.The pulse wave conduction speed detection system includes at least two synchronous the first photoelectric sensor modules and the second photoelectric sensor module, the pulse wave signal of the body surface artery of its position is obtained respectively, first photoelectric sensor module includes the first optical sensor, and the second photoelectric sensor module includes the second optical sensor;Fixed device, the first photoelectric sensor module and the second photoelectric sensor module are fixed on body surface artery by fixed device interval;Controller can obtain pulse wave signal, reach the time difference of the first optical sensor and the second optical sensor according to the distance between the first optical sensor and the second optical sensor and same pulse wave to obtain the conduction of velocity of pulse wave.A kind of pulse wave conduction speed detection system compact overall structure provided by the invention, easy to use, testing result accuracy is high, reproducible, testing result is reliable.
Description
Technical field
The invention belongs to pulse wave monitoring technical field in electronic medical equipment, it is related to being surveyed using optical device
Amount more particularly to a kind of pulse wave conduction speed detection system.
Background technique
Cardiovascular and cerebrovascular disease is the number one killer for causing human death, and China has 3,500,000 people to die of cardiovascular and cerebrovascular disease every year
Disease.Artery sclerosis caused by the damage of vascular function or structure is the initiating reason of cardiovascular and cerebrovascular disease, while being also heart and brain blood
The one of the important signs that of pipe disease risk degree.The artery of hardening can cause dominated region ischemic or bleeding and cause the heart,
The organ injuries such as brain, kidney.Therefore, the early screening of artery sclerosis and diagnosis to prevention and cure of cardiovascular disease, improve quality of life,
It is significant to extend the service life.
The early stage performance of artery sclerosis is the vessel wall elasticity variation prior to morphological change, and the conduction of pulse wave is fast
Degree (PWV) is then mainly determined by the elasticity of vascular wall.The elasticity of vascular wall weakens, subtracts to the resiliency of blood flow when artery sclerosis
Weak, PWV will accelerate.That is the size of PWV can reflect the hardness of arterial wall:PWV is bigger, and arterial elasticity is poorer.Cause
This, PWV measurement has become the index of classical detection arterial elasticity, is especially mainly used to detect Large artery elasticity function
" goldstandard " and the individual index that neck-femoral artery PWV (cfPWV) of energy is evaluated as cardio and vascular function, by many states
Family clinically applies, and is written into Chinese Hypertension Guidelines in 2010 and European Hypertension Guideline in 2013.
Since the detection of PWV is usually noninvasive, as the common people are to healthy and cognition of diseases raising, certainly will become
The necessary means of routine physical examination and cardio and vascular function evaluation.Therefore exploitation have pinpoint accuracy, high sensitivity, high duplication,
Convenient and simple easy-to-use PWV detecting instrument has very high clinical value.
PWV detection at present mainly has two major classes other:One is PWV (baPWV) of the measurement arteria brachialis to ankle artery, such as day
This Omron arterial stiffness detector BP-203RPEIII7;The second is measurement arteria carotis communis to femoral artery PWV (cfPWV, instead
Reflect aorta stiffness index), such as France Kang Pule arterial stiffness detector Complior SP series.Two kinds of PWV pass through formula
(PWV=L/PTT) it is calculated.L and PTT is pulse wave traveling respectively away from discrete time.Can be at surveyed pulse wave with
The distance between heart/time is also possible to distance/time difference at surveyed human body two between artery.
In addition to aorta in human body, arteria carotis communis is an other important elastic artery, the stiff degree one of tube wall
Determine the health status that can reflect aorta in degree.Arteria carotis communis hardening is the independentpredictor of cerebral apoplexy.Due to brain blood
Rostrum so ruptures or causes the cerebrovascular accident of brain tissue impairment (to be commonly called as because blood is caused to cannot flow into brain for angiemphraxis
" cerebral apoplexy ", " apoplexy "), there is the characteristics of high incidence, high mortality, high disability rate in China.Needed for post-stroke treatment
Expensive medical expense and the following burden on society make the diagnosis to risk factors of stroke and premonitory symptom, and close
Reason prevention and treatment becomes more significant.
In addition, arteria carotis communis hardening is also the independentpredictor of coronary heart disease etc., and especially in the elderly, arteria carotis communis
Stiffness index increases, dilatancy reduction is closely related with coronary heart disease, isolated systolic hypertension etc..Although coronarography
It is still " goldstandard " of diagnosis of coronary heart disease, but because it can not be popularized with traumatic and somewhat expensive, therefore to asymptomatic artery
Hardening, the early detection of coronary heart disease effect are little.
Currently, being clinically used to diagnose, assessing arteria carotis communis wall lesion to prevent and treat the means of arteria carotis communis hardening and be mainly
Arterial intima media thickness (IMT), Patch size, artery are directly measured in the systole phase using instruments such as high-frequency ultrasonics and are relaxed
The caliber for the phase of opening;Or it is obtained indirectly by measurement cfPWV.Arteria carotis communis ultrasound or color ultrasound can be shown in arteria carotis communis
Whether film (IMT) thicken, whether there is or not patches to be formed, patch is formed position and size, whether have hemadostewnosis and stenosis,
There is situations such as non-blocking, but the lesion on above-mentioned arterial wall structure belongs to the late stage of (athero-) hardening of artery, even if hair
It is existing, the prognosis treated and treated is helped limited.Additionally, due to the resolution of the limited resolution of ultrasonic wave, especially time
Rate is very low, therefore to the measurement of artery distensibility inaccuracy.And due to needing to be operated hardware check, measurement knot by professional
Fruit is easy to be influenced by subjective and external environment, and accurate rate is low, poor repeatability, costly, inconvenient to use.
Although cfPWV can be used as independent risk factor prediction coronary heart disease and cardiovascular event, arteria carotis communis part
PWV has not been reported.CfPWV is because measurement is inconvenient, high to operator's technology dependence and need the cooperation of testee's height etc.
Reason is gradually replaced baPWV;But baPWV contains excessive muscular artery part, no because measuring apart from long-range
The hardenability of central elastic artery can be accurately reflected as cfPWV.In addition, two kinds of traditional detection methods (baPWV and
CfPWV it) usually requires to be operated by trained professional, to technical requirements height, measurement result is easy by subjective and outer
Boundary's environment influences, and interference is big, precision is low, poor repeatability;Instrument itself is bulky, expensive, and testing cost is high;And
And due to needing subject to undress oneself, detection cycle is extended.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pulse wave conduction speed detection systems, using photoelectric sensing
Device obtains pulse wave conduction speed by measurement optical path and phase difference, and compact overall structure is easy to use, detection knot
Fruit accuracy is high, reproducible, testing result is reliable.
In order to solve the above technical problems, the present invention provides a kind of pulse wave conduction speed detection system, including:
At least two synchronous the first photoelectric sensor modules and the second photoelectric sensor module obtain its place respectively
The pulse wave signal of the body surface artery of position, first photoelectric sensor module include the first optical sensor, second light
Electrical sensor block includes the second optical sensor;
Fixed device, first photoelectric sensor module and the second photoelectric sensor module pass through the fixed device
Interval is fixed on body surface artery;
Controller can obtain the pulse wave signal, according between first optical sensor and the second optical sensor
Distance and same pulse wave reach the time difference of first optical sensor and the second optical sensor to obtain the conduction of pulse wave
Speed.
According to one embodiment of present invention, first photoelectric sensor module and the second photoelectric sensor module are equal
Including electronic control module, the optical signal of acquisition can be converted to the pulse wave signal by the electronic control module.
According to one embodiment of present invention, the fixed device includes a wear-type fixing clamp and a neck clip, the head
Formula fixing clamp is worn for first photoelectric sensor module to be fixed on body surface superficial temporal artery position, the neck clip is used for will
Second photoelectric sensor module is fixed on body surface arteria carotis communis position.
According to one embodiment of present invention, the wear-type fixing clamp includes first end and the second end, and described
One end and the second end fit in human face two sides, and first photoelectric sensor module is fixed at described first
End;The neck clip includes third end and the 4th end, and the third end and the 4th end fit in neck two
Side, second photoelectric sensor module are fixed at the third end;The first end and third end are located at people
Body is ipsilateral, and the third end is located at the lower section of the first end.
According to one embodiment of present invention, the wear-type fixing clamp and the neck clip are integrally formed.
According to one embodiment of present invention, first photoelectric sensor module and the second photoelectric sensor module are adopted
Connected with line synchro to realize synchronization, or both it is synchronous using wireless mode.
According to one embodiment of present invention, the line synchro has retractable structure, and mark is equipped on the line synchro
Ruler line is to show the distance between first photoelectric sensor module and second photoelectric sensor module.
According to one embodiment of present invention, first photoelectric sensor module and the second photoelectric sensor module be also
Including rechargeable battery and USB interface, the rechargeable battery can be charged by the USB interface.
According to one embodiment of present invention, first photoelectric sensor module and the second photoelectric sensor module be also
Including indicator light, for showing first photoelectric sensor module and the second photoelectric sensor module working condition or display
The remaining capacity of the rechargeable battery.
According to one embodiment of present invention, first photoelectric sensor module and the second photoelectric sensor module
Sample frequency is adjustable.
According to one embodiment of present invention, first optical sensor and the second optical sensor include laser light source,
Light wave waveguide and laser detector, the laser light source generate laser beam, anti-after the light wave waveguide incidence body surface artery
The light wave waveguide is injected, then is received by the laser detector.
According to one embodiment of present invention, the light wave waveguide is that N light wave is arrived in 1 to M multichannel optical waveguide array or 1
Lead switch;
Wherein M, N are integer and are greater than 1.
According to one embodiment of present invention, phase controlling component is equipped in the optical waveguide switch to change transmission
The phase of light beam in optical path.
According to one embodiment of present invention, first optical sensor and the second optical sensor further include lenticule, institute
It states laser light source and generates laser beam, enter institute through the light wave waveguide and by the lenticule incidence body surface artery back reflection
Lenticule is stated, then via the light wave waveguide, is finally received by the laser detector.
According to one embodiment of present invention, the lenticule is layer structure, has different refractivity comprising multilayer
Silicon oxynitride layer.
According to one embodiment of present invention, the lenticule and the light wave waveguide are integrally formed.
A kind of pulse wave conduction speed detection system provided by the invention, using fixed device by the first photoelectric sensor
Module and the second photoelectric sensor module interval are fixed on body surface artery surface, and the conduction of velocity of pulse wave is obtained with this, is made whole
A detection process is easy to operate, as a result reliably, accurately, repeatability it is high.
Detailed description of the invention
It is to provide further understanding of the invention including attached drawing, they are included and constitute part of this application,
Attached drawing shows the embodiment of the present invention, and plays the role of explaining the principle of the invention together with this specification.In attached drawing:
Fig. 1 shows the structural block diagram of the pulse wave conduction speed detection system of one embodiment of the invention.
Fig. 2 shows the structural schematic diagrams of the pulse wave conduction speed detection system of one embodiment of the invention.
Fig. 3 shows the usage state diagram of the pulse wave conduction speed detection system of one embodiment of the invention.
Fig. 4 shows the structural schematic diagram of the photoelectric sensor module of one embodiment of the invention.
Fig. 5 shows the superficial temporal artery of one embodiment of the invention and the schematic diagram of arteria carotis communis pulse wave.
Fig. 6 shows the knot of 1 Dao M multichannel optical waveguide array of the photoelectric sensor module of one embodiment of the invention
Structure schematic diagram.
Fig. 7 shows the structural representation of 1 Dao N optical waveguide switch of the photoelectric sensor module of one embodiment of the invention
Figure.
Fig. 8 A shows the structural schematic diagram of common optical waveguide in the prior art.
Fig. 8 B is the overlooking structure diagram of Fig. 8 A.
Fig. 9 A is the structural schematic diagram (one) that phase controlling component is provided on Fig. 8 A.
Fig. 9 B is the structural schematic diagram (two) that phase controlling component is provided on Fig. 8 A.
Fig. 9 C is the structural schematic diagram (three) that phase controlling component is provided on Fig. 8 A.
Figure 10 A shows light wave waveguide and the lenticule of the photoelectric sensor module of one embodiment of the invention
Perspective view.
Figure 10 B is the side structure schematic diagram of Figure 10 A.
Figure 11, which shows human pulse wave, can measure the schematic diagram at position.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.
Below in conjunction with the attached drawing in the embodiment of the present application, technical solutions in the embodiments of the present application carries out clear, complete
Site preparation description.Obviously, described embodiments are only a part of embodiments of the present application, instead of all the embodiments.Below
Description only actually at least one exemplary embodiment be it is illustrative, never as to the application and its application or
Any restrictions used.Based on the embodiment in the application, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, shall fall in the protection scope of this application.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root
According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singular shape
Formula be also intended to include plural form, additionally, it should be understood that, when in the present specification use term "comprising" and/or
When " comprising ", existing characteristics, step, operation, device, component and/or their combination are indicated.
Unless specifically stated otherwise, positioned opposite, the digital table of the component and step that otherwise illustrate in these embodiments
Up to the unlimited scope of the present application processed of formula and numerical value.Simultaneously, it should be appreciated that for ease of description, each portion shown in attached drawing
The size divided not is to draw according to actual proportionate relationship.For technology, side known to person of ordinary skill in the relevant
Method and equipment may be not discussed in detail, but in the appropriate case, and the technology, method and apparatus should be considered as authorization and say
A part of bright book.In shown here and discussion all examples, any occurrence should be construed as merely exemplary
, not as limitation.Therefore, the other examples of exemplary embodiment can have different values.It should be noted that:It is similar
Label and letter similar terms are indicated in following attached drawing, therefore, once being defined in a certain Xiang Yi attached drawing, then exist
In subsequent attached drawing do not need that it is further discussed.
In the description of the present application, it is to be understood that the noun of locality such as " front, rear, top, and bottom, left and right ", " lateral, perpendicular
To, it is vertical, horizontal " and " pushing up, bottom " etc. indicated by orientation or positional relationship be normally based on orientation or position shown in the drawings
Relationship is merely for convenience of description the application and simplifies description, and in the absence of explanation to the contrary, these nouns of locality are not
Indicate and imply that signified device or element must have a particular orientation or be constructed and operated in a specific orientation, therefore
It should not be understood as the limitation to the application protection scope;The noun of locality " inside and outside " refers in the profile relative to each component itself
Outside.
For ease of description, spatially relative term can be used herein, as " ... on ", " ... top ",
" ... upper surface ", " above " etc., for describing such as a device shown in the figure or feature and other devices or spy
The spatial relation of sign.It should be understood that spatially relative term is intended to comprising the orientation in addition to device described in figure
Except different direction in use or operation.For example, being described as if the device in attached drawing is squeezed " in other devices
It will be positioned as " under other devices or construction after part or construction top " or the device of " on other devices or construction "
Side " or " under other devices or construction ".Thus, exemplary term " ... top " may include " ... top "
" in ... lower section " two kinds of orientation.The device can also be positioned with other different modes and (is rotated by 90 ° or in other orientation),
And respective explanations are made to the opposite description in space used herein above.
In addition, it should be noted that, limiting components using the words such as " first ", " second ", it is only for be convenient for
Corresponding components are distinguished, do not have Stated otherwise such as, there is no particular meanings for above-mentioned word, therefore should not be understood as pair
The limitation of the application protection scope.In addition, although term used in this application is selected from public term
, but some terms mentioned in present specification may be that applicant is judged to carry out selection as his or her, in detail
Thin meaning illustrates in the relevant portion of description herein.Furthermore, it is desirable that not only by used actual terms, but
Also the application is understood by the meaning that each term is contained.
Fig. 1 shows the structural block diagram of the pulse wave conduction speed detection system of one embodiment of the invention.As schemed
Show, a kind of pulse wave conduction speed detection system 100 includes at least two synchronous the first photoelectric sensor modules 102 and the
Two photoelectric sensor modules 103 and controller 104 and fixed device.First photoelectric sensor module 102 and the second photoelectricity
Sensor module 103 can be fixed on the body surface artery position of human body, to obtain the body surface artery of its position respectively
Pulse wave signal.Wherein, the first photoelectric sensor module 102 includes the first optical sensor 105, the second photoelectric sensor module
103 include the second optical sensor 106.
Fixed device is used to for the first photoelectric sensor module 102 and the second photoelectric sensor module 103 interval being fixed on
On the body surface artery of human body.
Controller 104 can obtain the first photoelectric sensor module 102 and 103 pulse wave of the second photoelectric sensor module letter
Number, and the first light is reached according to the distance between the first optical sensor 105 and the second optical sensor 106 and same pulse wave and is passed
The time difference of sensor 105 and the second optical sensor 106 obtains the conduction of velocity of pulse wave.
Further, the first photoelectric sensor module 102 and the second photoelectric sensor module 103 include electronic control
Module 107.The optical signal that the electronic control module 107 can obtain the first optical sensor 105 and the second optical sensor 106 point
Pulse wave signal is not converted to.
Fig. 2 shows the structural schematic diagrams of the pulse wave conduction speed detection system of one embodiment of the invention.Fig. 3 shows
The usage state diagram of the pulse wave conduction speed detection system of one embodiment of the invention is gone out.As shown, fixed device packet
Include a wear-type fixing clamp 108 and a neck clip 109.Wear-type fixing clamp 108 is for consolidating the first photoelectric sensor module 102
It is scheduled on body surface superficial temporal artery position.Readily comprehensible, wear-type fixed frame 108 is similar to the Headphone structure worn when listening to music,
So that the first photoelectric sensor module 102 is tightly attached to superficial temporal artery position, is located substantially at 0.5cm before human body tragus.109 energy of neck clip
Enough and neck shape cooperates, and so that the second photoelectric sensor module 103 is close to body surface arteria carotis position, is located substantially at neck
The outer 2cm of Adam's apple.
Wear-type fixing clamp 108 includes first end 110 and the second end 111.Wear-type fixing clamp 108 passes through it certainly
The elastic deformation performance of body makes 111 elastic fit human face two sides of first end 110 and the second end.First photoelectric sensing
Device module 102 is fixed at first end 110.Neck clip 109 includes third end 112 and the 4th end 113, third end
112 and the 4th end 113 fit in neck two sides, the second photoelectric sensor module 103 is fixed at third end
112.Wherein, it is ipsilateral to be located at human body for first end 110 and third end 112, are shown on the right side of human body in Fig. 3, and third end
112 are located at the lower section of first end 110.
Pulse wave conduction speed detection system 100 proposed by the present invention passes through fixed device for the first photoelectric sensor mould
Block 102 and the second photoelectric sensor module 103 are respectively placed at human body head superficial temporal artery and arteria carotis communis, pass through controller
107 are calculated neck-Temporal Artery pulse wave conduction speed by the pulse wave signal obtained.This kind of pulse wave conduction speed detection
System 100 is lower to operator's technology dependence, and subject just can be used under sitting posture state without undressing oneself.Detection
As a result objective reliable, accuracy is high, reproducible, and since small in size, easy to carry, detection efficiency is high, solves clinic
The inconvenience of pulse wave conduction speed measurement, can be used for the screening of outpatient service large-scale crowd or homebrew, and can be used for assessing neck
The consistency and elasticity function of artery.
More preferably, wear-type fixing clamp 108 and neck clip 109 are integrally formed.
Preferably, the first photoelectric sensor module 102 is with the second photoelectric sensor module 103 using synchronous with reference to Figure 10
Line 114 is connected to realize synchronization.By way of example and not limitation, the first photoelectric sensor module 102 and the second photoelectric sensor mould
Block 103 can also be synchronized using wireless mode.More preferably, used line synchro 114 has retractable structure, should
Retractable structure can be spring or stretch pull-type, make line synchro 114 generally in the linear distance at its both ends.It is same at this
It walks line 114 and is equipped with scale line to show between the first photoelectric sensor module 102 and the second photoelectric sensor module 103
Distance.
Fig. 4 shows the structural schematic diagram of the photoelectric sensor module of one embodiment of the invention.As shown, first,
Second photoelectric sensor module 102,103 respectively includes the first optical sensor 105, the second optical sensor 106, further includes electronics
Control controller 107.First, second photoelectric sensor module 102,103 further includes rechargeable battery 115 and USB interface
116, rechargeable battery 115 can be charged by usb 1 16.Rechargeable battery 115 is for providing the first, second photoelectric sensing
Electric energy needed for device module 102,103.More preferably, the first, second photoelectric sensor module 102,103 further includes indicator light 117.
Indicator light 117 can show the working condition of the first, second photoelectric sensor module 102,103, to be confirmed whether working
In.Indicator light 117 can also show the remaining capacity of rechargeable battery 115, to charge in time.Usb 1 16 can be with
Sync cap as the first, second photoelectric sensor module 102,103.
Preferably, the sample frequency of the first, second photoelectric sensor module 102,103 is adjustable, it is dynamic to adapt to body surface difference
The pulse wave of arteries and veins position is strong and weak different.
Preferably, the first, second optical sensor 105,106 includes that laser light source 118, light wave waveguide 119 and laser are visited
Survey device 120.Wherein, laser light source 118 generates laser beam, and the incident beam 121 through the guidance output of light wave waveguide 119 is incident
Body surface artery back reflection forms emerging beam 122, and incident light sonic wave guide 119, again by laser detector after guided output
120 receive.Here body surface artery can be with the superficial temporal artery 201 or arteria carotis communis 202 in subcutaneous tissue 203.
Fig. 5 shows the superficial temporal artery of one embodiment of the invention and the schematic diagram of arteria carotis communis pulse wave.In conjunction with Fig. 4
Shown, laser light source 118 generates incident beam 121 and is incident on superficial temporal artery 201 or arteria carotis communis 202, then reflects to form out light
Light beam 122 is received by laser detector 120.Superficial temporal artery pulse wave 204, arteria carotis communis pulse wave are also shown in Fig. 5
205, superficial temporal artery pulse wave second dervative 206 and arteria carotis communis pulse wave second dervative 207, utilize superficial temporal artery pulse wave
204, arteria carotis communis pulse wave 205 calculates pulse wave translation time PTT (Δ T) in the peak acceleration of rising edge.According to first
The distance between optical sensor 105 and the second optical sensor 106 L and pulse wave translation time PTT (Δ T) obtains pulse wave
Neck Temporal Artery pulse wave conduction of velocity ctPWV=L/ Δ T.
Specifically, superficial temporal artery pulse wave 204 and arteria carotis communis pulse wave 205 can indicate that superficial temporal artery and neck always move
The pulse of the tube wall pressure change of arteries and veins position rises and falls, and pulse fluctuating can change incident beam 121, makes the light path of incident beam 121
It changes, so as to cause the phase change of incident beam 121.A pulse wave can generated each cardiac cycle
Peak value, the duplicate frequency of peak value is exactly heart rate.By the received emerging beam 122 of laser detector 120 contain superficial temporal artery and
The abundant information of the pulse wave of arteria carotis communis, these interference signals are passing through modulus sample conversion, energy after the operation such as denoising
It is passed to controller 104 enough to carry out the analysis of the data such as pulse wave.
Further, light wave waveguide 119 can be 1 to M multichannel optical waveguide array or 1 to N optical waveguide switch, wherein
M, N is integer and is greater than 1.It more preferably, is the detection validity for improving laser beam, the first, second optical sensor 105,106
Light wave waveguide 119 in be equipped with phase controlling component the directive property of incident beam 121 and emerging beam 122 is all controlled,
To which adjust automatically finds vascular pulsation most strength.
In one embodiment, 1 to M multichannel optical waveguide array includes the light splitting optical path unit of multistage 1 to 2, and 1
Each output light path after to the multichannel light splitting on the road M is equipped with phase controlling component.Fig. 6 shows one embodiment of the invention
Photoelectric sensor module 1 Dao M multichannel optical waveguide array structural schematic diagram, illustrate that 1 to 8 tunnels in figure
Optical waveguide array 46 includes 3 grade 1 to 2 of light splitting optical path unit 41, and phase controlling component is equipped on each output light path
42.Second laser 124 forms 8 tunnel output lights through light splitting optical path units 41 at different levels, and phase controlling component 42 can be adjusted per all the way
The phase of output light, all phase controlling components 42 can co-ordination, realize the angle of incident beam 121 and emerging beam 122
Degree control.
In another embodiment, 1 to N multichannel optical waveguide switch includes the optical waveguide switch unit of multistage 1 to 2, and
Phase controlling component is equipped in double transmission optical paths of each optical waveguide switch unit.Fig. 7 shows one embodiment of the invention
Photoelectric sensor module 1 Dao N optical waveguide switch structural schematic diagram, the optical waveguide on 1 to 8 tunnels is illustrated that in figure
Switch 47 includes 3 grade 1 to 2 of optical waveguide switch unit 71, in double transmission optical paths of each optical waveguide switch unit 71
Equipped with phase controlling component 42.Second laser 124 forms 8 tunnel output lights through optical waveguide switch units 71 at different levels.Phase control division
Part 42 can adjust the phase of the output light of each optical waveguide switch unit 71, i.e., carry out channel selecting to output light.All phases
Position control unit 42 can co-ordination, realize the channel control of incident beam 121 and emerging beam 122.In one embodiment
In, optical waveguide switch unit 71 is tied using MZI (Mach-Zehnder interferometer, Mach-Cen Deer interferometer)
Structure.
Even if the relative position of the first, second optical sensor 105,106 and body surface artery changes, pass through first,
Direction of the light wave waveguide 119 of two optical sensors 105,106 to laser beam (including incident beam 121 and emerging beam 122)
The control of property, is still able to maintain the validity of detection.Such as in the motion processes such as walk, run, the first, second optical sensor
105, it 106 can change with the relative position of superficial temporal artery 201 or arteria carotis communis 202, the signal-to-noise ratio drop of light wave waveguide 119
It is low, when find signal-to-noise ratio reduce after the first, second optical sensor 105,106 can closed loop change phase controlling component 42, pass through phase
Position control unit 42 adjusts angle or the channel of laser beam, to guarantee that incident beam 121 can be incident on body surface artery
On position, and emerging beam 122 can be received by laser detector 120, and then realize the validity of monitoring, reduced power consumption and mentioned
It is highly sensitive.
Fig. 8 A shows the structural schematic diagram of common optical waveguide in the prior art.Fig. 8 B is the plan structure signal of Fig. 8 A
Figure.As shown, transmission channel (basic light wave waveguiding structure) generally includes substrate 61, covering 62 and core waveguide 66.Laser
Light beam can enter from the side of core waveguide 66, and the other side goes out.
Fig. 9 A is the structural schematic diagram (one) that phase controlling component is provided on Fig. 8 A.Fig. 9 B is arranged on Fig. 8 A
The structural schematic diagram (two) of phase controlling component.Fig. 9 C is the structural schematic diagram that phase controlling component is provided on Fig. 8 A
(3).By way of example and not limitation, phase controlling component 42 can be one kind of following 3 kinds of structures.
With reference to Fig. 9 A, phase controlling component 42 includes the metallic film 63 being arranged on the covering 62 of output light path.Change speech
It, metallic film 63 can be deposited on covering 62.Phase controlling component 42 is by being powered heating to metallic film 63 to adjust
The refractive index of covering 62.
With reference to Fig. 9 B, phase controlling component 42 includes liquid crystal cell layer 64,67 and bipolar electrode 65.Liquid crystal cell layer 64,67
It can be liquid crystal packaged glass layer and liquid crystal material layer respectively.Liquid crystal cell layer 64,67 is stacked in the covering 62 of output light path
On, liquid crystal material can be injected on covering 62 in manufacture craft, bipolar electrode 65 is arranged on liquid crystal layer 64.Liquid crystal material
Refractive index can be changed by electric field, phase controlling component 42 adjusts liquid crystal cell layer by changing the voltage of bipolar electrode 65
64,67 refractive index.
With reference to Fig. 9 C, phase controlling component 42 includes polymeric layer 68 and bipolar electrode 65.The setting of polymeric layer 68 is exporting
On the covering 62 of optical path, polymer material can be injected on covering 62 in manufacture craft, bipolar electrode 65 is arranged in polymer
On layer 68.Because the refractive index of polymer material again may be by electric field change, phase controlling component 42 passes through change
The voltage of bipolar electrode 65 adjusts the refractive index of polymeric layer 68.
Fig. 4 is returned back to, the first, second optical sensor 105,106 further includes lenticule 125.Incident beam 121 is by micro-
Lens 125 reach superficial temporal artery 201 or arteria carotis communis 202, and emerging beam 122 arrives laser detector 120 by lenticule 125.
Preferably, lenticule 125 and light wave waveguide 119 are integrally formed.Specifically, lenticule 125 can be placed in light wave waveguide
In 119, i.e., to doing lens function processing on the interface of light wave waveguide 119 and free space.It should be understood that lenticule 125
The focussing force of light beam can be realized using discrete optical lens.
Figure 10 A shows light wave waveguide and the lenticule of the photoelectric sensor module of one embodiment of the invention
Perspective view.Figure 10 B is the side structure schematic diagram of Figure 10 A.With an output channel of the output end of light wave waveguide 119 and one
It is illustrated for a lenticule 48.With reference to Figure 10 B, left side is an output channel of the output end of light wave waveguide 119,
Right side is lenticule 48.Output channel (basic waveguiding structure) includes substrate 61, covering 62 and core waveguide 66.Covering 62 is logical
It crosses high-temperature oxidation process to be grown in substrate 61, core waveguide 66 runs through the output channel and lenticule 48.Lenticule 48 is layer
Shape structure, the multilayer comprising being arranged in around core waveguide 66 have silicon oxynitride layer 69-1,69-2,69- of different refractivity
3.Each layer silicon oxynitride layer 69-1,69-2,69-3 is grown on next layer by deposition method.It is in fact possible in core wave
It leads and two layers or three layers of silicon oxynitride layer is set below 66, can also be arranged below core waveguide 66 two layers or three layers
Silicon oxynitride layer, and each layer by process reform at the silicon oxynitride layer with different refractivity.From core waveguide 66
The refractive index of remoter silicon oxynitride layer is lower.By taking the realization of multichannel optical waveguide array as an example, laser beam is from core waveguide 66
Left side enters, and what is given off by lenticule 48 is all identical elliptic conic shape light beam, and these elliptic conic shape beam exit angles
Degree is consistent.When these light beams are when far field is superimposed, according to different controlled phases, far field beams can be in different spatial positions
Form controllable constructive or destructive interferences, that is to say, that the controllable convergence and scanning of laser beam may be implemented.In practical application
In, these controllable focus on light beam can be set predetermined position corresponding with body surface artery.
On the other hand, laser light source 118 uses near-infrared laser light source.The sharpest edges of near-infrared laser light source exist
There is high luminous efficiency and luminous intensity in the laser that it is issued, and the light beam of near infrared laser has side well
Tropism can effectively focus on the artery site for needing to monitor.
Figure 11, which shows human pulse wave, can measure the schematic diagram at position.As shown, it includes suitable that human body, which can measure position,
For the test point 1101 of superficial temporal artery 201, the test point 1102 of arteria carotis communis 202, the test point 1103 of arteria brachialis, oar is dynamic
Test point 1104, the test point 1106 of the 1105, popliteal nest artery of test point of femoral artery and the test point of ankle artery of arteries and veins
1107.Readily comprehensible, fixed device can also include other each in addition to including wear-type fixing clamp 108 and a neck clip 109
The fixing clamp of seed type by the first photoelectric sensor module 102 or the second photoelectric sensor module 103 to be fixed on the upper arm and move respectively
The test point 1103 of arteries and veins, the test point 1104 of radial artery, femoral artery 1105, popliteal nest artery of test point test point 1106 or
The test point 1107 of ankle artery.In this way, arbitrarily selecting the test point of two above-mentioned different artery positions, so that it may measure
Pulse wave conduction speed between the two test points.Certainly, the survey between two different test points of human body the same side
Dose-effect fruit is preferable.It should be noted that since measurement neck-Temporal Artery pulse wave conduction speed only needs to contact test point
1101,1102, mainly close to head side, therefore subject just can be used, in this way without undressing oneself under sitting posture state
So that measurement is whole more convenient, quick.
In conclusion a kind of pulse wave conduction speed detection system 100 provided by the invention needs not rely upon operator
Professional standards, subject can improve detection efficiency without undressing oneself.Especially it is used for the fixation of neck Temporal Artery detection
Device, so that seat is received detection can quickly and easily complete, and measurement is convenient, as a result reliably, accurately, repeatability it is high.With tradition
The baPWV and cfPWV that the Omron happy Complior SP of arterial stiffness detector BP-203RPEIII7 and Kang Pu is surveyed respectively into
After the experiment of row clinical comparison, validity and accuracy are more than the said goods.Especially ctPWV can be with early prediction brain blood
The generation of pipe disease and dead, and due to the stability of measurement, repeatability is high the features such as, can sensitively show that early stage brain is dynamic
The relationship of arteries and veins hardening and hypertension, cerebral apoplexy etc..
The pulse wave conduction speed obtained through the invention can be further used for cardiovascular and cerebrovascular disease early diagnosis, early stage sieves
It looks into, the screening of health assessment, therapeutic scheme, efficacy of new drug evaluation, the fields such as basic medical research, is that prevention and diagnosis and treatment are cardiovascular
The important tool of disease.Detection process is noninvasive lossless, and it is convenient to detect, and is that discovery and prevention cardiovascular disease are most effective, most convenient
Non-invasive detection instrument.
Those skilled in the art can be obvious, can carry out various modifications to the above exemplary embodiments of the invention and modification
Without departing from the spirit and scope of the present invention.Accordingly, it is intended to which present invention covering is made to fall in the appended claims and its equivalent skill
Modifications of the present invention and modification in art aspects.
Claims (16)
1. a kind of pulse wave conduction speed detection system, including
At least two synchronous the first photoelectric sensor modules and the second photoelectric sensor module, obtain its position respectively
The pulse wave signal of body surface artery, first photoelectric sensor module include the first optical sensor, second photoelectric sensing
Device module includes the second optical sensor;
Fixed device, first photoelectric sensor module and the second photoelectric sensor module are solid by the fixed device interval
It is scheduled on body surface artery;
Controller can obtain the pulse wave signal, according to the distance between first optical sensor and second optical sensor
And same pulse wave reaches the time difference of first optical sensor and the second optical sensor to obtain the conduction of velocity of pulse wave.
2. a kind of pulse wave conduction speed detection system as described in claim 1, which is characterized in that first photoelectric sensing
Device module and the second photoelectric sensor module include electronic control module, and the electronic control module can be by the optical signal of acquisition
Be converted to the pulse wave signal.
3. a kind of pulse wave conduction speed detection system as claimed in claim 2, which is characterized in that the fixed device includes
One wear-type fixing clamp and a neck clip, the wear-type fixing clamp are used to first photoelectric sensor module being fixed on body surface
Superficial temporal artery position, the neck clip are used to second photoelectric sensor module being fixed on body surface arteria carotis communis position.
4. a kind of pulse wave conduction speed detection system as claimed in claim 3, which is characterized in that the wear-type fixing clamp
Including first end and the second end, the first end and the second end fit in human face two sides, first photoelectricity
Sensor module is fixed at the first end;The neck clip includes third end and the 4th end, the third end
Neck two sides are fitted in the 4th end, second photoelectric sensor module is fixed at the third end;Institute
It states first end and third end is located at that human body is ipsilateral, and the third end is located at the lower section of the first end.
5. a kind of pulse wave conduction speed detection system as claimed in claim 3, which is characterized in that the wear-type fixing clamp
It is integrally formed with the neck clip.
6. a kind of pulse wave conduction speed detection system as described in claim 1, which is characterized in that first photoelectric sensing
Device module uses line synchro to connect to realize synchronization with the second photoelectric sensor module, or both it is synchronous using wireless mode.
7. a kind of pulse wave conduction speed detection system as claimed in claim 6, which is characterized in that the line synchro has can
Stretching structure is equipped with scale line on the line synchro to show first photoelectric sensor module and the second photoelectric sensor
The distance between module.
8. a kind of pulse wave conduction speed detection system as described in claim 1, which is characterized in that first photoelectric sensing
Device module and the second photoelectric sensor module further include rechargeable battery and USB interface, and the rechargeable battery can be by described
USB interface charging.
9. a kind of pulse wave conduction speed detection system as claimed in claim 8, which is characterized in that first photoelectric sensing
Device module and the second photoelectric sensor module further include indicator light, for showing first photoelectric sensor module and the second light
The remaining capacity of electrical sensor block working condition or the display rechargeable battery.
10. a kind of pulse wave conduction speed detection system as described in claim 1, which is characterized in that first photoelectric transfer
The sample frequency of sensor module and the second photoelectric sensor module is adjustable.
11. a kind of pulse wave conduction speed detection system as described in claim 1, which is characterized in that first light sensing
Device and the second optical sensor include laser light source, light wave waveguide and laser detector, and the laser light source generates laser beam,
Enter the light wave waveguide through the light wave waveguide incidence body surface artery back reflection, then is received by the laser detector.
12. a kind of pulse wave conduction speed detection system as claimed in claim 11, which is characterized in that the light wave waveguide is
1 to M multichannel optical waveguide array or 1 arrive N optical waveguide switch;
Wherein M, N are integer and are greater than 1.
13. a kind of pulse wave conduction speed detection system as claimed in claim 12, which is characterized in that opened in the optical waveguide
It is equipped with phase controlling component inside the Pass to change the phase of light beam in transmission optical path.
14. a kind of pulse wave conduction speed detection system as claimed in claim 13, which is characterized in that first light sensing
Device and the second optical sensor further include lenticule, and the laser light source generates laser beam, through the light wave waveguide and pass through institute
It states lenticule incidence body surface artery back reflection and enters the lenticule, then via the light wave waveguide, finally by the laser acquisition
Device receives.
15. a kind of pulse wave conduction speed detection system as claimed in claim 14, which is characterized in that the lenticule is layer
Shape structure has the silicon oxynitride layer of different refractivity comprising multilayer.
16. a kind of pulse wave conduction speed detection system as claimed in claim 14, which is characterized in that the lenticule and institute
State light wave waveguide integrated molding.
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