CN108841582A - One kind being used for blood cell separator - Google Patents
One kind being used for blood cell separator Download PDFInfo
- Publication number
- CN108841582A CN108841582A CN201810921946.XA CN201810921946A CN108841582A CN 108841582 A CN108841582 A CN 108841582A CN 201810921946 A CN201810921946 A CN 201810921946A CN 108841582 A CN108841582 A CN 108841582A
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- China
- Prior art keywords
- pressure vessel
- pedestal
- spring
- roller
- fixedly connected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000000601 blood cell Anatomy 0.000 title claims abstract description 15
- 210000004369 blood Anatomy 0.000 claims abstract description 23
- 239000008280 blood Substances 0.000 claims abstract description 23
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000001301 oxygen Substances 0.000 claims abstract description 13
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 13
- 238000009434 installation Methods 0.000 claims abstract description 12
- 230000001681 protective effect Effects 0.000 claims abstract description 6
- 239000007789 gas Substances 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 4
- 208000032839 leukemia Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003394 haemopoietic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 208000022532 enlargement of lymph nodes Diseases 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses one kind to be used for blood cell separator, including pedestal, installation cavity is equipped in the pedestal, driving device is equipped in the installation cavity, pressure vessel has been connected via drive in the pedestal, blood entry port is respectively equipped on the upside of the pressure vessel, first air exhaust nozzle, first high pressure oxygen entrance, the blood entry port is equipped with check valve, the pressure vessel bottom side is respectively equipped with blood outlet, second air exhaust nozzle, second high pressure oxygen entrance, the pressure vessel inner sidewall is equipped with protective film, filter layer is also fixedly connected on the pressure vessel inner sidewall, the pressure vessel bottom side is symmetrically arranged with support device.The present invention drives pressure vessel rotation by driving device, so that the second roller constantly squeezes groove, keeps connecting rod mobile, under the elastic force effect of spring, so that the second roller gradually slowly sticks into next groove, so that pressure vessel generates vibration, filter is helped quickly to be separated by filtration.
Description
Technical field
The present invention relates to blood cell technical fields, more particularly to one kind to be used for blood cell separator.
Background technique
Leukemia is leukaemia, is a kind of candidate stem cell malignant clone disease.Clonal leukaemia cell is because increase
Grow out of control, dysdifferentiation, mechanism largely proliferation accumulation in marrow and other hematopoietic tissues such as apoptosis is obstructed, and it is non-to infiltrate other
Hematopoietic tissue and organ, while inhibiting normal hematopoiesis function.Clinical visible different degrees of anaemia, bleeding, infectious fever and
Liver, spleen, enlargement of lymph nodes and skeleton pain.It is reported that the disease incidence of China each department leukaemia accounts for the 6th in various tumours
Position.
According to China Patent Publication No.：A kind of blood cancer cell separator of CN207493004U includes pressure vessel and filtering
Layer；The shape of the pressure vessel is closed two-way infundibulate, and the inner wall of pressure vessel is attached with protective film, pressure vessel
Top is provided with blood entry port, the first air exhaust nozzle and the first high pressure oxygen entrance, the lower part of pressure vessel be provided with blood outlet,
Second air exhaust nozzle and the second high pressure oxygen entrance；The blood entry port is provided with check valve；The filter layer is fixed on described
The two-way funnel shaped middle part of pressure vessel, and pressure vessel is isolated into two independent cavitys up and down；The filter layer includes
Supporter, and it is attached to the filter membrane on the supporter.Improvement of the device to cancer cell filter is filtering out big portion
The loss of normal plasma cell and the pollution of blood are avoided while dividing cancer cell, while increasing the oxygen content in blood again,
It achieves many things at one stroke.
But the device is when being separated, filter membrane top layer blood gradually cure in filtering, so that being separated by filtration
Speed gradually decrease, to increase the time being entirely separated by filtration, reduce separative efficiency.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, such as：When the device is separated, filter membrane
In filtering, gradually cure divides so that the speed being separated by filtration gradually decreases to increase entire filtering top layer's blood
From time, reduce separative efficiency.
To achieve the goals above, present invention employs following technical solutions：
One kind being used for blood cell separator, including pedestal, and installation cavity is equipped in the pedestal, is equipped with driving in the installation cavity
Device, the pedestal have been connected via drive pressure vessel, have been respectively equipped with blood entry port, first on the upside of the pressure vessel
Air exhaust nozzle, the first high pressure oxygen entrance, the blood entry port are equipped with check valve, and the pressure vessel bottom side is respectively equipped with blood
Outlet, the second air exhaust nozzle, the second high pressure oxygen entrance；
The pressure vessel inner sidewall is equipped with protective film, is also fixedly connected with filter layer on the pressure vessel inner sidewall, described
Pressure vessel bottom side is symmetrically arranged with support device, and first support bar, first support are symmetrically fixedly connected on the pedestal
Bar is fixedly connected with annular slab far from one end of pedestal, and the annular slab is equipped with multiple spring grooves, in each spring groove
It is equipped with elastic mechanism, the elastic mechanism is equipped with the second roller.
Preferably, the driving device includes motor, and the motor is fixedly connected on the inner wall of installation cavity, the motor
Output end on be fixedly connected with main shaft, the main shaft is fixedly connected on the bottom side of pressure vessel far from one end of motor.
Preferably, the support device includes second support bar, and one end of the second support bar is fixedly connected on pressure
The bottom side of container, the other end of the second support bar are rotatably connected to the first roller.
Preferably, the elastic mechanism includes spring, and the spring one end is fixedly connected on the side wall of spring groove, described
The other end of spring is fixedly connected with connecting rod, and second roller is rotatably connected on the one end of connecting rod far from spring.
Preferably, the pressure vessel is equipped with multiple grooves, and each groove matches with the second roller setting.
Preferably, the pedestal is equipped with annular groove, and the annular groove and the first roller match setting.
Compared with prior art, the beneficial effects of the invention are as follows：
1, main axis is driven by motor, main shaft drives pressure vessel to be rotated, so that the second roller constantly squeezes
Press slot, move connecting rod into spring groove, thus spring-compressed, under the elastic force effect of spring so that the second roller by
Next groove is gradually sticked into, the second roller can slightly beat recess sidewall when sticking into groove, so that pressure vessel generates vibration, help
Filter is quickly separated by filtration；
2, when pressure vessel is rotated, second support bar is rotated, while the first roller is rotated, and further
One roller slides in a ring groove, guarantees to possess enough support forces when pressure vessel rotation, reduces the support burden of main shaft.
Detailed description of the invention
Fig. 1 is a kind of positive structure schematic for blood cell separator proposed by the present invention；
Fig. 2 is a kind of vertical view anchor ring cross-sectional view for blood cell separator proposed by the present invention；
The structure enlargement diagram that A goes out in Fig. 3 bitmap 2.
In figure：1- pedestal, 2- filter layer, 3- protective film, 4- blood entry port, the first air exhaust nozzle of 5-, the first high pressure oxygen of 6-
Entrance, the outlet of 7- blood, the second air exhaust nozzle of 8-, the second high pressure oxygen of 9- entrance, 10- installation cavity, 11- motor, 12- main shaft, 13-
Pressure vessel, 14- annular slab, 15- first support bar, 16- second support bar, the first roller of 17-, 18- annular groove, 19- connection
Bar, the second roller of 20-, 21- spring, 22- spring groove, 23- groove, 24- check valve.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
In the description of the present invention, it is to be understood that, term " on ", "lower", "front", "rear", "left", "right",
The orientation or positional relationship of the instructions such as "top", "bottom", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, and is only
For the convenience of describing the present invention and simplifying the description, rather than the device or element of indication or suggestion meaning must have specific side
Position is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
Referring to Fig.1-3, a kind of to be used for blood cell separator, including pedestal 1, installation cavity 10, installation cavity are equipped in pedestal 1
Driving device is equipped in 10, driving device includes motor 11, and motor 11 is fixedly connected on the inner wall of installation cavity 10, motor 11
Main shaft 12 is fixedly connected on output end, main shaft 12 is fixedly connected on the bottom side of pressure vessel 13 far from one end of motor 11, leads to
It crosses motor 11 and driving force is provided, so that main shaft 12 be driven to be rotated, then pressure vessel 13 can be followed and be rotated, pedestal 1
Pressure vessel 13 has been connected via drive, blood entry port 4, the first air exhaust nozzle 5, first are respectively equipped on the upside of pressure vessel 13
High pressure oxygen entrance 6, blood entry port 4 are equipped with check valve 24, and 13 bottom side of pressure vessel is respectively equipped with blood outlet 7, second and takes out
Gas nozzle 8, the second high pressure oxygen entrance 9.
13 inner sidewall of pressure vessel is equipped with protective film 3, is also fixedly connected with filter layer 2 on 13 inner sidewall of pressure vessel, presses
13 bottom side of force container is symmetrically arranged with support device, and support device includes second support bar 16, and one end of second support bar 16 is fixed
It is connected to the bottom side of pressure vessel 13, the other end of second support bar 16 is rotatably connected to the first roller 17, and pedestal 1 is equipped with ring
Shape slot 18, annular groove 18 and the first roller 17 match setting, and when pressure vessel 13 is rotated, second support bar 16 is carried out
Rotation, while the first roller 17 is rotated, further the first roller 17 slides in annular groove 18, guarantees pressure vessel 13
Possess enough support forces when rotation, reduces the support burden of main shaft 12, be symmetrically fixedly connected with first support bar on pedestal 1
15, first support bar 15 is fixedly connected with annular slab 14 far from one end of pedestal 1, and annular slab 14 is equipped with multiple spring grooves 22,
Elastic mechanism is equipped in each spring groove 22, elastic mechanism includes spring 21, and 21 one end of spring is fixedly connected on spring groove 22
Side wall on, the other end of spring 21 is fixedly connected with connecting rod 19, and the second roller 20 is rotatably connected on connecting rod 19 far from bullet
One end of spring 21, pressure vessel 13 are equipped with multiple grooves 23, and each groove 23 matches with the second roller 20 setting, and second
It can be that connecting rod 19 squeezes spring 21 that roller 20, which squeezes groove 23, help 20 clamping of the second roller by the elastic force that spring 21 generates
Next groove 23, the second roller 20 can beat 23 side wall of groove when sticking into spring 21, and vibration effect can be generated to pressure vessel 13
Fruit, elastic mechanism are equipped with the second roller 20.
In the present invention, when user uses the device, blood is put into and is filtered separation in pressure vessel 13, is then opened
Dynamic motor 11 drives main shaft 12 to rotate by motor 11, and main shaft 12 drives pressure vessel 13 to be rotated, then second support bar
16 the first rollers 17 of drive slide in annular groove 18, while the second roller 20 being made constantly to squeeze groove 23, make connecting rod
19 move into spring groove 22, so that spring 21 compresses, under the elastic force effect of spring 21, so that the second roller 20 gradually sticks into
Next groove 23, when being caught in groove 23, the second roller 20 can slightly beat 23 side wall of groove, so that pressure vessel 13 generates vibration
It is dynamic, help the blood on filter layer 2 to be quickly separated by filtration.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. one kind is used for blood cell separator, including pedestal（1）, which is characterized in that the pedestal（1）It is interior to be equipped with installation cavity
（10）, the installation cavity（10）It is interior to be equipped with driving device, the pedestal（1）Pressure vessel has been connected via drive（13）,
The pressure vessel（13）Upside is respectively equipped with blood entry port（4）, the first air exhaust nozzle（5）, the first high pressure oxygen entrance（6）, institute
State blood entry port（4）It is equipped with check valve（24）, the pressure vessel（13）Bottom side is respectively equipped with blood outlet（7）, second take out
Gas nozzle（8）, the second high pressure oxygen entrance（9）；
The pressure vessel（13）Inner sidewall is equipped with protective film（3）, the pressure vessel（13）It is also fixedly connected on inner sidewall
Filter layer（2）, the pressure vessel（13）Bottom side is symmetrically arranged with support device, the pedestal（1）On be symmetrically fixedly connected with
One support rod（15）, the first support bar（15）Far from pedestal（1）One end be fixedly connected with annular slab（14）, the annular
Plate（14）It is equipped with multiple spring grooves（22）, each spring groove（22）Elastic mechanism is inside equipped with, on the elastic mechanism
Equipped with the second roller（20）.
2. according to claim 1 a kind of for blood cell separator, which is characterized in that the driving device includes electricity
Machine（11）, the motor（11）It is fixedly connected on installation cavity（10）Inner wall on, the motor（11）Output end on fixed connect
It is connected to main shaft（12）, the main shaft（12）Far from motor（11）One end be fixedly connected on pressure vessel（13）Bottom side.
3. a kind of blood cell separator to be used for according to claim 1, which is characterized in that the support device includes the
Two support rods（16）, the second support bar（16）One end be fixedly connected on pressure vessel（13）Bottom side, described second
Strut（16）The other end be rotatably connected to the first roller（17）.
4. according to claim 1 a kind of for blood cell separator, which is characterized in that the elastic mechanism includes bullet
Spring（21）, the spring（21）One end is fixedly connected on spring groove（22）Side wall on, the spring（21）The other end fix
It is connected with connecting rod（19）, second roller（20）It is rotatably connected on connecting rod（19）Far from spring（21）One end.
5. according to claim 1 a kind of for blood cell separator, which is characterized in that the pressure vessel（13）On
Equipped with multiple grooves（23）, each groove（23）With the second roller（20）Match setting.
6. according to claim 1 a kind of for blood cell separator, which is characterized in that the pedestal（1）It is equipped with
Annular groove（18）, the annular groove（18）With the first roller（17）Match setting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810921946.XA CN108841582A (en) | 2018-08-14 | 2018-08-14 | One kind being used for blood cell separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810921946.XA CN108841582A (en) | 2018-08-14 | 2018-08-14 | One kind being used for blood cell separator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108841582A true CN108841582A (en) | 2018-11-20 |
Family
ID=64193081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810921946.XA Pending CN108841582A (en) | 2018-08-14 | 2018-08-14 | One kind being used for blood cell separator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108841582A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4123307B1 (en) * | 2008-02-22 | 2008-07-23 | 日本精工株式会社 | Annular parts for calibration, shaft parts, bearings, and manufacturing methods thereof |
| US20160340638A1 (en) * | 2012-12-14 | 2016-11-24 | Chong Zheng | Centrifugal dynamic filtering apparatus and cell separation system using same |
| CN107843503A (en) * | 2017-10-17 | 2018-03-27 | 安徽电信器材贸易工业有限责任公司 | A kind of fiber optic cable twist test device |
| KR20180044729A (en) * | 2016-10-24 | 2018-05-03 | 한국과학기술원 | Device for filtering blood |
| CN207493004U (en) * | 2017-03-16 | 2018-06-15 | 孙衍伟 | A kind of blood cancer cell separator |
-
2018
- 2018-08-14 CN CN201810921946.XA patent/CN108841582A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4123307B1 (en) * | 2008-02-22 | 2008-07-23 | 日本精工株式会社 | Annular parts for calibration, shaft parts, bearings, and manufacturing methods thereof |
| US20160340638A1 (en) * | 2012-12-14 | 2016-11-24 | Chong Zheng | Centrifugal dynamic filtering apparatus and cell separation system using same |
| KR20180044729A (en) * | 2016-10-24 | 2018-05-03 | 한국과학기술원 | Device for filtering blood |
| CN207493004U (en) * | 2017-03-16 | 2018-06-15 | 孙衍伟 | A kind of blood cancer cell separator |
| CN107843503A (en) * | 2017-10-17 | 2018-03-27 | 安徽电信器材贸易工业有限责任公司 | A kind of fiber optic cable twist test device |
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